Human Gene Module / Chromosome 5 / ADRB2

ADRB2adrenergic, beta-2-, receptor, surface

SFARI Gene Score
2
Strong Candidate Criteria 2.1
Autism Reports / Total Reports
2 / 10
Rare Variants / Common Variants
0 / 4
Aliases
ADRB2, BAR,  B2AR,  ADRBR,  ADRB2R,  BETA2AR
Associated Syndromes
-
Chromosome Band
5q32
Associated Disorders
-
Relevance to Autism

Studies have found genetic association between the ADRB2 gene and autism. Association was found in the AGRE cohort along with additional samples.

Molecular Function

This gene encodes beta-2-adrenergic receptor which is a member of the G protein- coupled receptor superfamily.

SFARI Genomic Platforms
Reports related to ADRB2 (10 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Positive Association beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins Connors SL , et al. (2006) Yes -
2 Recent Recommendation beta(2)-Adrenoceptor-mediated facilitation of glutamatergic transmission in rat ventromedial hypothalamic neurons Lee JG , et al. (2006) No -
3 Recent Recommendation Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins Ho G , et al. (2006) No -
4 Primary beta2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort Cheslack-Postava K , et al. (2007) Yes -
5 Recent Recommendation Crystal structure of the human beta2 adrenergic G-protein-coupled receptor Rasmussen SG , et al. (2007) No -
6 Recent Recommendation High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Cherezov V , et al. (2007) No -
7 Recent Recommendation Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks Neves SR , et al. (2008) No -
8 Recent Recommendation Quantitative mRNA analysis of serotonin 5-HT? and adrenergic ?? receptors in the mouse embryonic telencephalon Hernandez MC and Januonis S (2010) No -
9 Highly Cited Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor Goodman OB Jr , et al. (1996) No -
10 Highly Cited Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A Daaka Y , et al. (1997) No -
Rare Variants  

No rare variants reported.

Common Variants   (4)
Status Allele Change Residue Change Variant Type Inheritance Pattern Paternal Transmission Family Type PubMed ID Author, Year
c.46A>G p.Arg16Gly missense_variant - - - 16417856 Connors SL , et al. (2006)
c.79C>G p.Gln27Glu missense_variant - - - 16417856 Connors SL , et al. (2006)
c.46A>G p.Arg16Gly missense_variant - - - 17199132 Cheslack-Postava K , et al. (2007)
c.79C>G p.Gln27Glu missense_variant - - - 17199132 Cheslack-Postava K , et al. (2007)
SFARI Gene score
2

Strong Candidate

Gene from a significant but unreplicated association study (Cheslack-Postava K).

Score Delta: Score remained at 2

2

Strong Candidate

See all Category 2 Genes

We considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.

4/1/2022
3
icon
2

Decreased from 3 to 2

Description

Gene from a significant but unreplicated association study (Cheslack-Postava K).

10/1/2019
4
icon
3

Decreased from 4 to 3

New Scoring Scheme
Description

Gene from a significant but unreplicated association study (Cheslack-Postava K).

Reports Added
[New Scoring Scheme]
7/1/2014
No data
icon
4

Increased from No data to 4

Description

Gene from a significant but unreplicated association study (Cheslack-Postava K).

4/1/2014
No data
icon
4

Increased from No data to 4

Description

Gene from a significant but unreplicated association study (Cheslack-Postava K).

Krishnan Probability Score

Score 0.41016715447818

Ranking 22718/25841 scored genes


[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning approach on a human brain-specific gene network. The method was first presented in Nat Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed in column G of supplementary table 3 (see: http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser, with the ability to view networks of associated ASD risk genes, can be found at asd.princeton.edu.
ExAC Score

Score 0.47649310404724

Ranking 5579/18225 scored genes


[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of- function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of- function mutations in autism in such a gene would be more likely to confer risk. For a full list of pLI scores see: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle aned_exac_nonTCGA_z_pli_rec_null_data.txt
Sanders TADA Score

Score 0.92662900151777

Ranking 10480/18665 scored genes


[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013), and is a statistic that integrates evidence from both de novo and transmitted mutations. It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233 (2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper (the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Larsen Cumulative Evidence Score

Score 30

Ranking 71/461 scored genes


[Show Scoring Methodology]
Larsen and colleagues generated gene scores based on the sum of evidence for all available ASD-associated variants in a gene, with assessments based on mode of inheritance, effect size, and variant frequency in the general population. The approach was first presented in Mol Autism 7:44 (2016), and scores for 461 genes can be found in column I in supplementary table 4 from that paper.
Zhang D Score

Score -0.15457928804051

Ranking 14269/20870 scored genes


[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures), or D score, was developed to combine evidence from de novo loss-of- function mutation with evidence from cell-type- specific gene expression in the mouse brain (specifically translational profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with positive D scores are more likely to be associated with autism risk, with higher-confidence genes having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204- 215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in supplementary table 2 from that paper.
Interaction Table
Interactor Symbol Interactor Name Interactor Organism Interactor Type Entrez ID Uniprot ID
2-Mar E3 ubiquitin-protein ligase MARCH2 Human Protein Binding 51257 Q9P0N8
ACTG1 actin, gamma 1 Human Protein Binding 71 P63261
ADRB2 adrenergic, beta-2-, receptor, surface Human Protein Binding 154 P07550
ADRBK1 adrenergic, beta, receptor kinase 1 Human Protein Modification 156 P25098
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 Human Protein Binding 9131 O95831
AKAP12 A kinase (PRKA) anchor protein 12 Human Protein Binding 9590 Q02952
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 Human Protein Binding 5832 P54886
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase Human Protein Binding 267 Q9UKV5
Arrb2 Beta-arrestin-2 Rat Protein Binding 25388 P29067
ARRDC3 arrestin domain containing 3 Human Protein Binding 57561 Q96B67
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide Human Protein Binding 476 P05023
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide Human Protein Binding 483 P54709
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Human Protein Binding 488 P16615
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 Human Protein Binding 493 P23634
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle Human Protein Binding 498 P25705
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide Human Protein Binding 506 P06576
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 Human Protein Binding 509 P36542
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit Human Protein Binding 539 P48047
C19orf6 transmembrane protein 259 Human Protein Binding 91304 B3KTL0
C1QBP complement component 1, q subcomponent binding protein Human Protein Binding 708 Q07021
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit Human Protein Binding 775 Q13936
CALM1 calmodulin 1 (phosphorylase kinase, delta) Human Protein Binding 801 P62158
CALM2 calmodulin 2 (phosphorylase kinase, delta) Human Protein Binding 805 P62158
CALM3 calmodulin 3 (phosphorylase kinase, delta) Human Protein Binding 808 B4DJ51
CANX calnexin Human Protein Binding 821 P27824
CAPNS1 calpain, small subunit 1 Human Protein Binding 826 P04632
CAV3 caveolin 3 Rat Protein Binding 29161 P51638
CLGN Calmegin Human Protein Binding 1047 O14967
CNNM3 cyclin M3 Human Protein Binding 26505 Q8NE01
CUL2 cullin 2 Human Protein Binding 8453 Q13617
DAD1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Human Protein Binding 1603 P61803
DLAT dihydrolipoamide S-acetyltransferase Human Protein Binding 1737 P10515
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 Human Protein Binding 51726 Q9UBS4
DSG2 desmoglein 2 Human Protein Binding 1829 Q14126
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 Human Protein Binding 1915 P68104
EEF1B2 eukaryotic translation elongation factor 1 beta 2 Human Protein Binding 1933 P24534
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) Human Protein Binding 1936 B2RAR6
EEF1G eukaryotic translation elongation factor 1 gamma Human Protein Binding 1937 P26641
EEF2 eukaryotic translation elongation factor 2 Human Protein Binding 1938 P13639
EGLN3 egl nine homolog 3 (C. elegans) Human Protein Binding 112399 Q9H6Z9
EIF2B1 Translation initiation factor eIF-2B subunit alpha Human Protein Binding 1967 Q14232
EIF4A1 eukaryotic translation initiation factor 4A1 Human Protein Binding 1973 P60842
ERLIN2 ER lipid raft associated 2 Human Protein Binding 11160 O94905
ETFB Electron transfer flavoprotein subunit beta Human Protein Binding 2109 P38117
FAM162A Protein FAM162A Human Protein Binding 26355 Q96A26
FKBP8 FK506 binding protein 8, 38kDa Human Protein Binding 23770 Q14318
FLNA filamin A, alpha Human Protein Binding 2316 P21333
GAPDH glyceraldehyde-3-phosphate dehydrogenase Human Protein Binding 2597 P04406
GCDH glutaryl-CoA dehydrogenase Human Protein Binding 2639 Q92947
GFM1 G elongation factor, mitochondrial 1 Human Protein Binding 85476 E5KND5
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 Human Protein Binding 2771 B3KP24
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Human Protein Binding 2773 P08754
GNAS Neuroendocrine secretory protein 55 Human Protein Binding 2778 O95467
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 Human Protein Binding 2782 P62873
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 Human Protein Binding 2783 P62879
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Human Protein Binding 10399 P63244
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 Human Protein Binding 59345 Q9HAV0
GNG12 guanine nucleotide binding protein (G protein), gamma 12 Human Protein Binding 55970 Q69YP5
GNG2 guanine nucleotide binding protein (G protein), gamma 2 Human Protein Binding 54331 P59768
GRK6 G protein-coupled receptor kinase 6 Human Protein Modification 2870 P43250
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit Human Protein Binding 3032 P55084
HLA-B major histocompatibility complex, class I, B Human Protein Binding 3106 P01889
HLA-C major histocompatibility complex, class I, C Human Protein Binding 3107 O19617
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 Human Protein Binding 3181 P22626
HNRNPF eterogeneous nuclear ribonucleoprotein F Human Protein Binding 3185 P52597
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) Human Protein Binding 3187 P31943
HNRNPK heterogeneous nuclear ribonucleoprotein K Human Protein Binding 3190 P61978
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) Human Protein Binding 3192 Q00839
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 Human Protein Binding 51144 Q53GQ0
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 Human Protein Binding 3295 B2R659
HSDL2 hydroxysteroid dehydrogenase like 2 Human Protein Binding 84263 Q6YN16
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 Human Protein Binding 7184 P14625
HSPA1A heat shock 70kDa protein 1A Human Protein Binding 3303 P08107
HSPA1B heat shock 70kDa protein 1B Human Protein Binding 3304 A8K5I0
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Human Protein Binding 3309 Q2KHP4
HSPA9 heat shock 70kDa protein 9 (mortalin) Human Protein Binding 3313 P38646
HSPD1 heat shock 60kDa protein 1 (chaperonin) Human Protein Binding 3329 P10809
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial Human Protein Binding 3418 P48735
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha Human Protein Binding 3419 P50213
IDH3B isocitrate dehydrogenase 3 (NAD+) beta Human Protein Binding 3420 O43837
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma Human Protein Binding 3421 P51553
ILVBL ilvB (bacterial acetolactate synthase)-like Human Protein Binding 10994 A1L0T0
IMMT inner membrane protein, mitochondrial Human Protein Binding 10989 Q16891
ITCH itchy E3 ubiquitin protein ligase Human Protein Binding 83737 Q96J02
JKAMP JNK1/MAPK8-associated membrane protein Human Protein Binding 51528 Q9P055
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 Human Protein Binding 3760 B4DEW7
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 Human Protein Binding 3762 P48544
KIAA0368 KIAA0368 Human Protein Binding 23392 J3KN16
KPNB1 karyopherin (importin) beta 1 Human Protein Binding 3837 Q14974
KRT1 keratin 1 Human Protein Binding 3848 P04264
KRT10 keratin 10 Human Protein Binding 3858 P13645
KRT2 keratin 2 Human Protein Binding 3849 P35908
KRT5 keratin 5 Human Protein Binding 3852 P13647
KRT9 keratin 9 Human Protein Binding 3857 P35527
LMNB1 lamin B1 Human Protein Binding 4001 P20700
LONP1 lon peptidase 1, mitochondrial Human Protein Binding 9361 P36776
LRPPRC leucine-rich pentatricopeptide repeat containing Human Protein Binding 10128 E5KNY5
MAPK14 mitogen-activated protein kinase 14 Human Protein Binding 1432 Q16539
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) Human Protein Binding 64087 Q9HCC0
MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) Human Protein Binding 4193 Q00987
MRPL12 mitochondrial ribosomal protein L12 Human Protein Binding 6182 P52815
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase Human Protein Binding 4522 G3V2B8
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Human Protein Binding 25902 B7ZM99
MYLK2 myosin light chain kinase 2 Human Protein Binding 85366 Q9H1R3
NDUFA4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa Human Protein Binding 4697 O00483
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa Human Protein Binding 4698 Q16718
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) Human Protein Binding 4720 O75306
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) Human Protein Binding 4722 O75489
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa Human Protein Binding 4723 P49821
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 Human Protein Binding 4734 P46934
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) Human Protein Binding 55666 Q8TAT6
NSF N-ethylmaleimide-sensitive factor Human Protein Binding 4905 P46459
NUP155 nucleoporin 155kDa Human Protein Binding 9631 O75694
NUP210 nucleoporin 210kDa Human Protein Binding 23225 Q8TEM1
NUP93 nucleoporin 93kDa Human Protein Binding 9688 Q8N1F7
OAT ornithine aminotransferase Human Protein Binding 4942 P04181
OPRD1 Delta-type opioid receptor Human Protein Binding 4985 P41143
OXTR oxytocin receptor Human Protein Binding 5021 P30559
PC pyruvate carboxylase Human Protein Binding 5091 P11498
PCBP1 poly(rC) binding protein 1 Human Protein Binding 5093 Q15365
PCBP2 poly(rC) binding protein 2 Human Protein Binding 5094 Q15366
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 Human Protein Binding 5160 P08559
PDHB pyruvate dehydrogenase (lipoamide) beta Human Protein Binding 5162 P11177
PDIA6 protein disulfide isomerase family A, member 6 Human Protein Binding 10130 Q15084
PGRMC1 progesterone receptor membrane component 1 Human Protein Binding 10857 O00264
PHB prohibitin Human Protein Binding 5245 P35232
PHB2 prohibitin 2 Human Protein Binding 11331 Q99623
PON2 paraoxonase 2 Human Protein Binding 5445 Q15165
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme Human Protein Binding 5530 Q08209
PRKDC protein kinase, DNA-activated, catalytic polypeptide Human Protein Binding 5591 P78527
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Human Protein Binding 5708 Q13200
PTGER1 Prostaglandin E2 receptor EP1 subtype Human Protein Binding 5731 P34995
RAB18 RAB18, member RAS oncogene family Human Protein Binding 22931 Q9NP72
RAN RAN, member RAS oncogene family Human Protein Binding 5901 A8K3Z8
RANBP2 RAN binding protein 2 Human Protein Binding 5903 P49792
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) Human Protein Binding 5966 Q04864
RNF5 ring finger protein 5, E3 ubiquitin protein ligase Human Protein Binding 6048 Q99942
RPLP1 ribosomal protein, large, P1 Human Protein Binding 6176 P05386
RPN1 ribophorin I Human Protein Binding 6184 P04843
RPN2 ribophorin II Human Protein Binding 6185 P04844
RPS5 ribosomal protein S5 Human Protein Binding 6193 P46782
SEC22B Vesicle-trafficking protein SEC22b Human Protein Binding 9554 O75396
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) Human Protein Binding 29927 P61619
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) Human Protein Binding 871 A8K259
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) Human Protein Binding 6472 P34897
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 Human Protein Binding 6510 B4DWS4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 Human Protein Binding 1468 Q9UBX3
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 Human Protein Binding 8402 Q6IBH0
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 Human Protein Binding 10165 Q9UJS0
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 Human Protein Binding 5250 Q00325
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 Human Protein Binding 292 P05141
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 Human Protein Binding 293 P12236
SLC39A14 solute carrier family 39 (zinc transporter), member 14 Human Protein Binding 23516 Q15043
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Human Protein Binding 9368 O14745
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 Human Protein Binding 9351 Q6NTG0
SLIRP SRA stem-loop interacting RNA binding protein Human Protein Binding 81892 Q9GZT3
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 Human Protein Binding 10558 O15269
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Human Protein Binding 6714 P12931
SRPRB signal recognition particle receptor, B subunit Human Protein Binding 58477 Q549N5
SSR4 signal sequence receptor, delta Human Protein Binding 6748 P51571
STOM stomatin Human Protein Binding 2040 P27105
SV2A Synaptic vesicle glycoprotein 2A Human Protein Binding 9900 Q7L0J3
SYNJ2BP synaptojanin 2 binding protein Human Protein Binding 55333 P57105
TARDBP TAR DNA binding protein Human Protein Binding 23435 Q13148
TFRC transferrin receptor (p90, CD71) Human Protein Binding 7037 P02786
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) Human Protein Binding 92609 Q3ZCQ8
TM9SF3 transmembrane 9 superfamily member 3 Human Protein Binding 56889 Q9HD45
TMEM33 transmembrane protein 33 Human Protein Binding 55161 P57088
TMUB1 transmembrane and ubiquitin-like domain containing 1 Human Protein Binding 83590 Q9BVT8
TMX1 thioredoxin-related transmembrane protein 1 Human Protein Binding 81542 Q9H3N1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) Human Protein Binding 9868 O94826
TRAF1 TNF receptor-associated factor 1 Human Protein Binding 7185 Q13077
TTN titin Human Protein Binding 7273 Q8WZ42
TUBB tubulin, beta Human Protein Binding 203068 P07437
TUFM Tu translation elongation factor, mitochondrial Human Protein Binding 7284 P49411
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 Human Protein Binding 7311 P62987
UBB ubiquitin B Human Protein Binding 7314 P0CG47
UBXN8 UBX domain-containing protein 8 Human Protein Binding 7993 O00124
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Human Protein Binding 7345 P09936
UFD1L ubiquitin fusion degradation 1 like (yeast) Human Protein Binding 7353 Q541A5
UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial Human Protein Binding 7385 P22695
USP20 ubiquitin specific peptidase 20 Human Protein Binding 10868 Q9Y2K6
USP33 ubiquitin specific peptidase 33 Human Protein Binding 23032 Q8TEY7
VCP valosin containing protein Human Protein Binding 7415 P55072
VDAC2 voltage-dependent anion channel 2 Human Protein Binding 7417 P45880
VHL von Hippel-Lindau tumor suppressor Human Protein Binding 7428 P40337
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