Human Gene Module / Chromosome 3 / ATP2B2

ATP2B2ATPase, Ca++ transporting, plasma membrane 2

SFARI Gene Score
2
Strong Candidate Criteria 2.1
Autism Reports / Total Reports
12 / 15
Rare Variants / Common Variants
24 / 7
Aliases
ATP2B2, PMCA2,  PMCA2a,  PMCA2i
Associated Syndromes
-
Chromosome Band
3p25.3
Associated Disorders
-
Relevance to Autism

Genetic association has been found between the ATP2B2 gene and autism in a combined AGRE, ISART (Italian) and US cohort (Carayol et al., 2011). A de novo missense variant that was predicted to be damaging (p.Thr818Met) was identified in the ATP2B2 gene in an ASD proband from the Simons Simplex Collection in Iossifov et al., 2014, and two de novo nonsense variants in this gene were observed in ASD probands from Japanese trios in Takata et al., 2018. TADA analysis using a combined dataset of previously published cohorts from the Simons Simplex Collection and the Autism Sequencing Consortium, as well as the Japanese ASD cohort from Takata et al., 2018, identified ATP2B2 as a gene significantly enriched in damaging de novo mutations in ASD cases (pBH < 0.05). Functional analysis of the ASD-associated p.Thr818Met missense variant, which was originally identified in an SSC proband, in Drosophila in Marcogliese et al., 2022 demonstrated a loss-of-function effect (failure to reduce expected viability to the extent of corresponding reference allele upon ubiquitous overexpression; wing-specific overexpression of mutant ATP2B2 failed to induce the curled wing phenotype caused by overexpression of reference ATP2B2).

Molecular Function

This gene encodes the plasma membrane calcium ATPase isoform 2. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis.

External Links
Gene CardOpen Targets PlatformgnomAD browserSynGO portalPubMed
Human
Entrez GeneOMIMUniProtHumanBaseVariCarta
Mouse
Entrez GeneMouse Genome InformaticsAllen Brain Atlas
SFARI Genomic Platforms
GPF browser SFARI genome browser
Reports related to ATP2B2 (15 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Primary Converging evidence for an association of ATP2B2 allelic variants with autism in male subjects Carayol J , et al. (2011) Yes -
2 Positive Association The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families Prandini P , et al. (2012) Yes -
3 Positive Association The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population Yang W , et al. (2013) Yes -
4 Recent Recommendation Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder Vardarajan BN , et al. (2013) No -
5 Support Synaptic, transcriptional and chromatin genes disrupted in autism De Rubeis S , et al. (2014) Yes -
6 Support The contribution of de novo coding mutations to autism spectrum disorder Iossifov I et al. (2014) Yes -
7 Positive Association Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017) Yes -
8 Support Exonic Mosaic Mutations Contribute Risk for Autism Spectrum Disorder Krupp DR , et al. (2017) Yes -
9 Recent Recommendation Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder Takata A , et al. (2018) Yes -
10 Support - Rodin RE et al. (2021) Yes -
11 Support - Marcogliese PC et al. (2022) Yes -
12 Support - Zhou X et al. (2022) Yes -
13 Support - More RP et al. (2023) Yes -
14 Recent Recommendation - Poggio E et al. (2023) No ASD or autistic features, epilepsy/seizures
15 Support - et al. () No -
Rare Variants   (24)
Status Allele Change Residue Change Variant Type Inheritance Pattern Parental Transmission Family Type PubMed ID Author, Year
c.1043-19C>T - intron_variant De novo - - 25363760 De Rubeis S , et al. (2014)
c.2511+26G>A - intron_variant De novo - - 25363760 De Rubeis S , et al. (2014)
c.478T>C p.Ser160Pro missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.707T>A p.Ile236Asn missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.1801A>G p.Thr601Ala missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.1903T>G p.Cys635Gly missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.3634G>A p.Ala1212Thr missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.2133A>G p.Pro711%3D synonymous_variant De novo - - 35982159 Zhou X et al. (2022)
c.1330_1332del p.Phe444del inframe_deletion De novo - - 35982159 Zhou X et al. (2022)
c.2268C>A p.Cys756Ter stop_gained De novo - Simplex 29346770 Takata A , et al. (2018)
c.2577dup p.Ser860GlnfsTer14 frameshift_variant De novo - Simplex 37788244 et al. ()
c.3191G>A p.Trp1064Ter stop_gained De novo - Simplex 29346770 Takata A , et al. (2018)
c.358G>A p.Gly120Arg missense_variant De novo - Simplex 37675773 Poggio E et al. (2023)
c.2511G>T p.Met837Ile missense_variant De novo - Simplex 37675773 Poggio E et al. (2023)
c.2633T>C p.Phe878Ser missense_variant De novo - Simplex 37675773 Poggio E et al. (2023)
c.3028G>A p.Glu1010Lys missense_variant De novo - Simplex 37675773 Poggio E et al. (2023)
c.2757G>A p.Thr919= synonymous_variant De novo - Simplex 28867142 Krupp DR , et al. (2017)
c.2047C>T p.Pro683Ser missense_variant Familial - Multiplex 36702863 More RP et al. (2023)
c.2453C>T p.Thr818Met missense_variant De novo - Simplex 25363768 Iossifov I et al. (2014)
c.3254dup p.Thr1086AspfsTer64 frameshift_variant De novo - Simplex 37675773 Poggio E et al. (2023)
c.358G>C p.Gly120Arg missense_variant Unknown Not maternal Simplex 37675773 Poggio E et al. (2023)
c.3338_3339del p.Val1113GlyfsTer36 frameshift_variant De novo - Simplex 37675773 Poggio E et al. (2023)
c.3725_3726insCGCTTT p.Ser1242_Leu1243insAlaLeu inframe_insertion De novo - - 35982159 Zhou X et al. (2022)
ENSG00000157087:ENST00000460129:exon11:c.G1817A:p.R606H,ENSG00000157087:ENST00000360273:exon14:c.G19 - missense_variant De novo - - 33432195 Rodin RE et al. (2021)
Common Variants   (7)
Status Allele Change Residue Change Variant Type Inheritance Pattern Paternal Transmission Family Type PubMed ID Author, Year
c.2703+9G>T;c.2568+9G>T;c.2610+9G>T;c.2670+9G>T - intron_variant - - - 21757185 Carayol J , et al. (2011)
c.3357G>A;c.3222G>A;c.3264G>A;c.3324G>A p.(=) synonymous_variant - - - 22739633 Prandini P , et al. (2012)
c.1660-296C>T;c.1525-296C>T;c.1567-296C>T;c.1627-296C>T N/A intron_variant - - - 21757185 Carayol J , et al. (2011)
c.2136+3306A>G;c.2001+3306A>G;c.2043+3306A>G;c.2103+3306A>G C/T intron_variant - - - 23620727 Yang W , et al. (2013)
c.2136+3387A>G;c.2001+3387A>G;c.2043+3387A>G;c.2103+3387A>G N/A intron_variant - - - 21757185 Carayol J , et al. (2011)
c.1417-1174C>T;c.1282-1174C>T;c.1324-1174C>T - intron_variant - - - 28540026 Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017)
c.1417-1608G>A;c.1282-1608G>A;c.1324-1608G>A - intron_variant - - - 28540026 Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017)
SFARI Gene score
2

Strong Candidate

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3E10-5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression). A de novo missense variant that was predicted to be damaging was identified in the ATP2B2 gene in an ASD proband from the Simons Simplex Collection in Iossifov et al., 2014, and two de novo nonsense variants in this gene were observed in ASD probands from Japanese trios in Takata et al., 2018. TADA analysis using a combined dataset of previously published cohorts from the Simons Simplex Collection and the Autism Sequencing Consortium, as well as the Japanese ASD cohort from Takata et al., 2018, identified ATP2B2 as a gene significantly enriched in damaging de novo mutations in ASD cases (pBH < 0.05).

Score Delta: Score remained at 2

criteria met
See SFARI Gene'scoring criteria
2

Strong Candidate

See all Category 2 Genes

We considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.

1/1/2021
2
icon
2

Score remained at 2

Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3E10-5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression). A de novo missense variant that was predicted to be damaging was identified in the ATP2B2 gene in an ASD proband from the Simons Simplex Collection in Iossifov et al., 2014, and two de novo nonsense variants in this gene were observed in ASD probands from Japanese trios in Takata et al., 2018. TADA analysis using a combined dataset of previously published cohorts from the Simons Simplex Collection and the Autism Sequencing Consortium, as well as the Japanese ASD cohort from Takata et al., 2018, identified ATP2B2 as a gene significantly enriched in damaging de novo mutations in ASD cases (pBH < 0.05).

Reports Added
[The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing2021]
10/1/2019
3
icon
2

Decreased from 3 to 2

New Scoring Scheme
Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3E10-5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression). A de novo missense variant that was predicted to be damaging was identified in the ATP2B2 gene in an ASD proband from the Simons Simplex Collection in Iossifov et al., 2014, and two de novo nonsense variants in this gene were observed in ASD probands from Japanese trios in Takata et al., 2018. TADA analysis using a combined dataset of previously published cohorts from the Simons Simplex Collection and the Autism Sequencing Consortium, as well as the Japanese ASD cohort from Takata et al., 2018, identified ATP2B2 as a gene significantly enriched in damaging de novo mutations in ASD cases (pBH < 0.05).

Reports Added
[New Scoring Scheme]
10/1/2017
3
icon
3

Decreased from 3 to 3

Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3E10-5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression).

Reports Added
[Exonic Mosaic Mutations Contribute Risk for Autism Spectrum Disorder.2017]
4/1/2017
3
icon
3

Decreased from 3 to 3

Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3 ? 10?5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression).

Reports Added
[The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families.2012] [The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.2013] [Converging evidence for an association of ATP2B2 allelic variants with autism in male subjects.2011] [Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder.2013] [Synaptic, transcriptional and chromatin genes disrupted in autism.2014] [The contribution of de novo coding mutations to autism spectrum disorder2014] [Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with ...2017]
1/1/2016
3
icon
3

Decreased from 3 to 3

Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3 ? 10?5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression).

Reports Added
[The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families.2012] [The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.2013] [Converging evidence for an association of ATP2B2 allelic variants with autism in male subjects.2011] [Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder.2013] [Synaptic, transcriptional and chromatin genes disrupted in autism.2014] [The contribution of de novo coding mutations to autism spectrum disorder2014]
7/1/2014
No data
icon
3

Increased from No data to 3

Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3 ? 10?5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression).

4/1/2014
No data
icon
3

Increased from No data to 3

Description

This gene is under a replicated linkage peak at 3p25 (PMID 16205737) and is differentially expressed in lymphoblasts from discordant sib pairs (PMID 19492049). The gene also shows male-specific common variant association (p = 5.3 ? 10?5) after combination of discovery and replication cohorts (PMID 21757185; category score was obtained via category 4.3 with altered expression).

Krishnan Probability Score

Score 1

Ranking 1/25841 scored genes


[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning approach on a human brain-specific gene network. The method was first presented in Nat Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed in column G of supplementary table 3 (see: http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser, with the ability to view networks of associated ASD risk genes, can be found at asd.princeton.edu.
Original Source
ExAC Score

Score 0.99992150647326

Ranking 646/18225 scored genes


[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of- function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of- function mutations in autism in such a gene would be more likely to confer risk. For a full list of pLI scores see: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle aned_exac_nonTCGA_z_pli_rec_null_data.txt
Original Source
Sanders TADA Score

Score 0.9443141799457

Ranking 16027/18665 scored genes


[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013), and is a statistic that integrates evidence from both de novo and transmitted mutations. It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233 (2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper (the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Original Source
Larsen Cumulative Evidence Score

Score 5

Ranking 274/461 scored genes


[Show Scoring Methodology]
Larsen and colleagues generated gene scores based on the sum of evidence for all available ASD-associated variants in a gene, with assessments based on mode of inheritance, effect size, and variant frequency in the general population. The approach was first presented in Mol Autism 7:44 (2016), and scores for 461 genes can be found in column I in supplementary table 4 from that paper.
Original Source
Zhang D Score

Score 0.35379125541735

Ranking 1967/20870 scored genes


[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures), or D score, was developed to combine evidence from de novo loss-of- function mutation with evidence from cell-type- specific gene expression in the mouse brain (specifically translational profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with positive D scores are more likely to be associated with autism risk, with higher-confidence genes having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204- 215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in supplementary table 2 from that paper.
Original Source
External PIN Data
BioGRIDHuman Protein Reference Database
Interactome
Interaction Table
Interactor Symbol Interactor Name Interactor Organism Interactor Type Entrez ID Uniprot ID
ABCB9 ADORA2A Human Protein Binding 23457 Q9NP78
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 Human Protein Binding 89845 Q5T3U5
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Human Protein Binding 10257 O15439
ABCD1 AGBL4 Human Protein Binding 215 P33897
ABCD4 ATP-binding cassette sub-family D member 4 Human Protein Binding 5826 O14678
ADAMTS4 ASS1 Human Protein Binding 9507 O75173
ALG10 ALG10, alpha-1,2-glucosyltransferase Human Protein Binding 84920 Q5BKT4
ALG8 ALG8, alpha-1,3-glucosyltransferase Human Protein Binding 79053 A6NDW6
Ania-3/Homer homer homolog 1 (Drosophila) Rat Protein Binding 29546 Q9Z214
APOD Apolipoprotein D Human Protein Binding 347 P05090
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 Human Protein Binding 23204 Q15041
ATG9A autophagy related 9A Human Protein Binding 79065 Q7Z3C6
ATP2B3 Plasma membrane calcium-transporting ATPase 3 Human Protein Binding 492 Q16720-2
ATP9A ATPase, class II, type 9A Human Protein Binding 10079 O75110
ATPBD4 diphthamine biosynthesis 6 Human Protein Binding NM_001141972 Q7L8W6
AZGP1 Zinc-alpha-2-glycoprotein Human Protein Binding 563 P25311
BCAP31 B-cell receptor-associated protein 31 Human Protein Binding 10134 P51572
BRP44 mitochondrial pyruvate carrier 2 Human Protein Binding NM_015415 A0A024R8Z5
BTBD9 BTB (POZ) domain containing 9 Human Protein Binding 114781 Q96Q07
C12ORF49 chromosome 12 open reading frame 49 Human Protein Binding 79794 Q9H741
C6ORF72 glycoprotein integral membrane 1 Human Protein Binding 116254 Q9NU53
CD79B B-cell antigen receptor complex-associated protein beta chain Human Protein Binding 974 P40259-2
CD83 ITGB7 Human Protein Binding 9308 Q01151
CHSY1 chondroitin sulfate synthase 1 Human Protein Binding 22856 Q86X52
CLU clusterin Human Protein Binding 1191 P10909
CYP2B6 Cytochrome P450 2B6 Human Protein Binding 1555 P20813
DGAT1 PCDHA13 Human Protein Binding 8694 O75907
DHRS7 Dehydrogenase/reductase SDR family member 7 Human Protein Binding 51635 Q9Y394-2
DHRS9 Dehydrogenase/reductase SDR family member 9 Human Protein Binding 10170 Q9BPW9
DLG1 discs, large homolog 1 (Drosophila) Human Protein Binding 1739 Q12959
EDNRB Endothelin B receptor Human Protein Binding 1910 P24530-3
EFNB2 ephrin-B2 Human Protein Binding 1948 P52799
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 Human Protein Binding 57089 Q9NQZ7
ERMP1 endoplasmic reticulum metallopeptidase 1 Human Protein Binding 79956 B3KSB1
FAM174A Membrane protein FAM174A Human Protein Binding 345757 Q8TBP5
FAR2 fatty acyl CoA reductase 2 Human Protein Binding 55711 Q96K12
FPR2 N-formyl peptide receptor 2 Human Protein Binding 2358 P25090
FZD10 TYR Human Protein Binding 11211 Q6NSL8
FZD7 frizzled family receptor 7 Human Protein Binding 8324 O75084
GALNT6 UBR7 Human Protein Binding 11226 Q8NCL4
GLB1L2 Beta-galactosidase-1-like protein 2 Human Protein Binding 89944 Q8IW92
GOLGA5 golgin A5 Human Protein Binding 9950 Q8TBA6
GOLIM4 golgi integral membrane protein 4 Human Protein Binding 27333 O00461
GOLM1 golgi membrane protein 1 Human Protein Binding 51280 B3KNK9
GPAM Human Protein Binding
GPR161 G protein-coupled receptor 161 Human Protein Binding 23432 B7Z5Z6
GPR89A Golgi pH regulator A Human Protein Binding 51463 B7ZAQ6-2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A Rat Protein Binding 24409 Q00959
HSD17B6 17-beta-hydroxysteroid dehydrogenase type 6 Human Protein Binding 8630 O14756
HTR2C 5-hydroxytryptamine receptor 2C Human Protein Binding 3358 P28335
HTR3A 5-hydroxytryptamine receptor 3A Human Protein Binding 3359 P46098-2
IL1R2 Human Protein Binding
IL29 Interferon lambda-1 Human Protein Binding 282618 Q8IU54
LASS6 Ceramide synthase 6 Human Protein Binding 253782 Q6ZMG9
LCLAT1 lysocardiolipin acyltransferase 1 Human Protein Binding 253558 Q6UWP7
LEMD2 LEM domain containing 2 Human Protein Binding 221496 Q8NC56
LGALS8 Galectin-8 Human Protein Binding 3964 O00214
LILRB4 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human Protein Binding 11006 Q8NHJ6-2
MAOB Amine oxidase [flavin-containing] B Human Protein Binding 4129 P27338
MUCL1 Mucin-like protein 1 Human Protein Binding 118430 Q96DR8
NOS3 nitric oxide synthase 3 (endothelial cell) Human Protein Binding 4846 P60323
NRM Human Protein Binding
OSTC oligosaccharyltransferase complex subunit (non-catalytic) Human Protein Binding 58505 Q9NRP0
PCDHGB1 Protocadherin gamma-B1 Human Protein Binding 56104 Q9Y5G3-2
PCNXL3 pecanex-like 3 (Drosophila) Human Protein Binding 399909 Q9H6A9
PDZD11 PDZ domain containing 11 Human Protein Binding 51248 Q5EBL8
PIGN phosphatidylinositol glycan anchor biosynthesis, class N Human Protein Binding 23556 O95427
PIGO phosphatidylinositol glycan anchor biosynthesis, class O Human Protein Binding 84720 Q8TEQ8
PRKCA protein kinase C, alpha Rat Protein Modification 24680 Q9EP80
PTGFR Prostaglandin F2-alpha receptor Human Protein Binding 5737 P43088
PTGIR Prostacyclin receptor Human Protein Binding 5739 P43119
RHOT2 ras homolog family member T2 Human Protein Binding 89941 Q8IXI1
SCARA3 Scavenger receptor class A member 3 Human Protein Binding 51435 Q6AZY7-2
SDF4 stromal cell derived factor 4 Human Protein Binding 51150 Q9BRK5
SLC15A4 solute carrier family 15, member 4 Human Protein Binding 121260 Q8N697
SLC22A16 Solute carrier family 22 member 16 Human Protein Binding 85413 Q86VW1
SLC26A6 Solute carrier family 26 member 6 Human Protein Binding 65010 Q9BXS9-2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 Human Protein Binding 6518 P22732
SLC38A9 Sodium-coupled neutral amino acid transporter 9 Human Protein Binding 153129 Q8NBW4-2
SLC45A2 Membrane-associated transporter protein Human Protein Binding 51151 D6RGY6
SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) Human Protein Binding 6522 P04920
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Human Protein Binding 9497 B5M449
SNTA1 syntrophin, alpha 1 Human Protein Binding 6640 Q13424
SPACA1 Sperm acrosome membrane-associated protein 1 Human Protein Binding 81833 Q9HBV2
SQLE squalene epoxidase Human Protein Binding 6713 Q14534
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Human Protein Binding 6482 Q11201
STEAP3 STEAP family member 3, metalloreductase Human Protein Binding 55240 Q658P3
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) Human Protein Binding 100287932 O14925
TMEM168 transmembrane protein 168 Human Protein Binding 64418 Q9H0V1
TMEM5 Transmembrane protein 5 Human Protein Binding 10329 Q9Y2B1
TMEM63A CSC1-like protein 1 Human Protein Binding 9725 O94886
TMEM63B transmembrane protein 63B Human Protein Binding 55362 Q5T3F8
TNPO3 transportin 3 Human Protein Binding 23534 B3KMX1
TOR1A torsin family 1, member A (torsin A) Human Protein Binding 1861 O14656
TRABD TraB domain containing Human Protein Binding 80305 Q9H4I3
VAC14 Vac14 homolog (S. cerevisiae) Human Protein Binding 55697 Q08AM6
VAV1 Human Protein Binding
VSIG4 V-set and immunoglobulin domain-containing protein 4 Human Protein Binding 11326 Q9Y279
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