Human Gene Module / Chromosome 7 / HOXA1

HOXA1homeobox A1

SFARI Gene Score
S
Syndromic Syndromic
Autism Reports / Total Reports
11 / 16
Rare Variants / Common Variants
15 / 2
Aliases
HOXA1, BSAS,  HOX1,  HOX1F,  MGC45232
Associated Syndromes
Bosley-Salih-Alorainy syndrome
Chromosome Band
7p15.2
Associated Disorders
ID, ASD
Relevance to Autism

Studies have found genetic association and rare variants in the HOXA1 gene that are identified with autism. Positive associations have been found in Caucasian and Chinese Han populations. However, several studies have found no association between HOXA1 and autism, including in Irish and Italian population samples, the South Carolina Autism Project cohort, the Collaborative Programs of Excellence in Autism cohort and in a meta-analysis of several studies combined. In addition, rare variants in the HOXA1 gene have been identified with Bosley-Salih-Alorainy syndrome (BSAS).

Molecular Function

The encoded protein is a transcription factor that plays a major role in brainstem and cranial morphogenesis.

External Links
Gene CardOpen Targets PlatformgnomAD browserPubMed
Human
Entrez GeneOMIMUniProtHumanBaseVariCarta
Mouse
Entrez GeneMouse Genome InformaticsAllen Brain Atlas
SFARI Genomic Platforms
GPF browser SFARI genome browser
Reports related to HOXA1 (16 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Primary Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders Ingram JL , et al. (2000) Yes -
2 Negative Association Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families Li J , et al. (2002) Yes -
3 Negative Association No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network Devlin B , et al. (2002) Yes -
4 Negative Association No association between HOXA1 and HOXB1 genes and autism spectrum disorders (ASD) Talebizadeh Z , et al. (2002) Yes -
5 Negative Association Lack of association of HOXA1 and HOXB1 mutations and autism in Sicilian (Italian) patients Romano V , et al. (2003) Yes -
6 Negative Association The HOXA1 A218G polymorphism and autism: lack of association in white and black patients from the South Carolina Autism Project Collins JS , et al. (2003) Yes -
7 Negative Association No association between allelic variants of HOXA1/HOXB1 and autism Gallagher L , et al. (2003) Yes -
8 Positive Association Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism Conciatori M , et al. (2004) Yes -
9 Recent Recommendation Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development Tischfield MA , et al. (2005) No ID, ASD
10 Recent Recommendation Polyhistidine tract expansions in HOXA1 result in intranuclear aggregation and increased cell death Paraguison RC , et al. (2005) No -
11 Recent Recommendation MicroRNA fingerprints during human megakaryocytopoiesis Garzon R , et al. (2006) No -
12 Support Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders Schaaf CP , et al. (2011) Yes -
13 Negative Association An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders Song RR , et al. (2011) Yes -
14 Recent Recommendation Allelic variation within the putative autism spectrum disorder risk gene homeobox A1 and cerebellar maturation in typically developing children and adolescents Raznahan A , et al. (2012) No -
15 Support - Zhou X et al. (2022) Yes -
16 Highly Cited Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning Studer M , et al. (1998) No -
Rare Variants   (15)
Status Allele Change Residue Change Variant Type Inheritance Pattern Parental Transmission Family Type PubMed ID Author, Year
c.218A>G p.His73Arg missense_variant - - - 11840501 Li J , et al. (2002)
del9 - inframe_deletion Familial Paternal - 11091361 Ingram JL , et al. (2000)
c.218A>G p.His73Arg missense_variant Unknown - - 11091361 Ingram JL , et al. (2000)
c.691G>A p.Ala231Thr missense_variant De novo - Multiplex 35982159 Zhou X et al. (2022)
c.183C>G p.Ile61Met missense_variant Unknown - Simplex 21624971 Schaaf CP , et al. (2011)
c.972del p.Ser325LeufsTer7 frameshift_variant Unknown - Simplex 21624971 Schaaf CP , et al. (2011)
c.207_215del p.His72_His74del inframe_deletion Unknown - Simplex 21624971 Schaaf CP , et al. (2011)
c.76C>T p.Arg26Ter stop_gained Familial Both parents Simplex 16155570 Tischfield MA , et al. (2005)
c.84C>G p.Tyr28Ter stop_gained Familial Both parents Simplex 16155570 Tischfield MA , et al. (2005)
c.193_194insCCA p.His65delinsProAsn inframe_insertion Unknown - Simplex 21624971 Schaaf CP , et al. (2011)
c.193_194insCCACCA p.His65delinsProThrAsn inframe_insertion Unknown - Simplex 21624971 Schaaf CP , et al. (2011)
c.174_175insC p.Val59ArgfsTer119 stop_gained Familial Both parents Multiplex 16155570 Tischfield MA , et al. (2005)
c.174_175insC p.Val59ArgfsTer119 frameshift_variant Familial Both parents Simplex 16155570 Tischfield MA , et al. (2005)
c.174_175insC p.Val59ArgfsTer119 frameshift_variant Familial Both parents Multiplex 16155570 Tischfield MA , et al. (2005)
c.213_215del p.His74del inframe_deletion Familial (6 cases); de novo (2 cases); unknown (27 cases) - Simplex 21624971 Schaaf CP , et al. (2011)
Common Variants   (2)
Status Allele Change Residue Change Variant Type Inheritance Pattern Paternal Transmission Family Type PubMed ID Author, Year
c.218A>G p.His73Arg missense_variant - - - 11091361 Ingram JL , et al. (2000)
c.218A>G p.His73Arg missense_variant - - - 14960295 Conciatori M , et al. (2004)
SFARI Gene score
S

Syndromic

HOXA1 mutations have been reported in brainstem malformation syndrome accompanied by ASD (Tischfield et al., 2005). There are a number of studies that report associations (not genome-wide significant), which would put it in category 4S. Finally, there are associations with autism-associated features such as head circumference (Conciatori et al., 2004), which boosts it to category 3S.

Score Delta: Score remained at S

criteria met
See SFARI Gene'scoring criteria
S

Syndromic

See all Category S Genes

The syndromic category includes mutations that are associated with a substantial degree of increased risk and consistently linked to additional characteristics not required for an ASD diagnosis. If there is independent evidence implicating a gene in idiopathic ASD, it will be listed as "#S" (e.g., 2S, 3S, etc.). If there is no such independent evidence, the gene will be listed simply as "S."

10/1/2019
S
icon
S

Score remained at S

New Scoring Scheme
Description

HOXA1 mutations have been reported in brainstem malformation syndrome accompanied by ASD (Tischfield et al., 2005). There are a number of studies that report associations (not genome-wide significant), which would put it in category 4S. Finally, there are associations with autism-associated features such as head circumference (Conciatori et al., 2004), which boosts it to category 3S.

Reports Added
[New Scoring Scheme]
Krishnan Probability Score

Score 0.49151940186456

Ranking 5470/25841 scored genes


[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning approach on a human brain-specific gene network. The method was first presented in Nat Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed in column G of supplementary table 3 (see: http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser, with the ability to view networks of associated ASD risk genes, can be found at asd.princeton.edu.
Original Source
ExAC Score

Score 0.084987363165592

Ranking 8027/18225 scored genes


[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of- function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of- function mutations in autism in such a gene would be more likely to confer risk. For a full list of pLI scores see: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle aned_exac_nonTCGA_z_pli_rec_null_data.txt
Original Source
Sanders TADA Score

Score 0.92769995463372

Ranking 10734/18665 scored genes


[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013), and is a statistic that integrates evidence from both de novo and transmitted mutations. It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233 (2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper (the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Original Source
Zhang D Score

Score -0.47734432031163

Ranking 19054/20870 scored genes


[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures), or D score, was developed to combine evidence from de novo loss-of- function mutation with evidence from cell-type- specific gene expression in the mouse brain (specifically translational profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with positive D scores are more likely to be associated with autism risk, with higher-confidence genes having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204- 215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in supplementary table 2 from that paper.
Original Source
Interactome
Interaction Table
Interactor Symbol Interactor Name Interactor Organism Interactor Type Entrez ID Uniprot ID
1700001C02Rik RIKEN cDNA 1700001C02 gene Mouse Direct Regulation 75434 Q9DAS2
1700011H14Rik RIKEN cDNA 1700011H14 gene Mouse Direct Regulation 67082 Q9CPZ1
1700025L06Rik RIKEN cDNA 1700025L06 gene Mouse Direct Regulation 66933 N/A
1700100I10Rik RIKEN cDNA 1700100I10 gene Mouse Direct Regulation 74982 N/A
2010003K15Rik RIKEN cDNA 2010003K15 gene Mouse Direct Regulation 100504474 J3QMJ4
2310046K01Rik RIKEN cDNA 2310046K01 gene Mouse Direct Regulation 69698 Q9D6X5
4930426D05Rik RIKEN cDNA 4930426D05 gene Mouse Direct Regulation 74644 Q9D5L2
4930522N08Rik RIKEN cDNA 4930522N08 gene Mouse Direct Regulation 75094 N/A
5730446D14Rik RIKEN cDNA 5730446D14 gene Mouse Direct Regulation 66640 N/A
6330407J23Rik RIKEN cDNA 6330407J23 gene Mouse Direct Regulation 67412 Q6NZL0
6430562O15Rik RIKEN cDNA 6430562O15 gene Mouse Direct Regulation 320893 N/A
6720473M11Rik RIKEN cDNA 6720473M11 gene Mouse Direct Regulation 77900 N/A
9.13E+15 uncharacterized 9130022E09 Mouse Direct Regulation 74564 N/A
9130016M20Rik RIKEN cDNA 9130016M20 gene Mouse Direct Regulation 71620 N/A
9330159F19Rik RIKEN cDNA 9330159F19 gene Mouse Direct Regulation 212448 D3Z623
9330185C12Rik RIKEN cDNA 9330185C12 gene Mouse Direct Regulation 77511 N/A
9430076C15Rik RIKEN cDNA 9430076C15 gene Mouse Direct Regulation 320189 N/A
9530051E23Rik RIKEN cDNA 9530051E23 gene Mouse Direct Regulation 319699 N/A
A930011O12Rik RIKEN cDNA A930011O12 gene Mouse Direct Regulation 268755 N/A
A930038C07Rik RIKEN cDNA A930038C07 gene Mouse Direct Regulation 68169 Q8C119
AADAC arylacetamide deacetylase (esterase) Mouse Direct Regulation 67758 Q99PG0
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mouse Direct Regulation 12780 Q8VI47
ABRA actin-binding Rho activating protein Mouse Direct Regulation 223513 Q8BUZ1
ACK1 Activated CDC42 kinase 1 Human Direct Regulation 10188 Q07912
ADAM12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) Mouse Direct Regulation 11489 Q61824
Adam5 a disintegrin and metallopeptidase domain 5 Mouse Direct Regulation 11499 Q3TTE0
ADAMTS16 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16 Mouse Direct Regulation 271127 Q69Z28
Adh1 alcohol dehydrogenase 1 (class I) Mouse Direct Regulation 11522 P00329
AI256396 EST AI256396 Mouse Direct Regulation 100503463 N/A
AI317395 expressed sequence AI317395 Mouse Direct Regulation 215929 Q8VCV9
ALDOB aldolase B, fructose-bisphosphate Mouse Direct Regulation 230163 Q91Y97
AMDHD1 amidohydrolase domain containing 1 Mouse Direct Regulation 71761 Q9DBA8
AMN amnionless Mouse Direct Regulation 93835 Q99JB7
Ang4 angiogenin, ribonuclease A family, member 4 Mouse Direct Regulation 219033 Q3TMQ6
Ang6 angiogenin, ribonuclease A family, member 6 Mouse Direct Regulation 630952 Q5GAN0
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) Mouse Direct Regulation 107765 Q9CR42
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B Mouse Direct Regulation 72074 Q8K3X6
APOA2 apolipoprotein A-II Mouse Direct Regulation 11807 P09813
APOB apolipoprotein B Mouse Direct Regulation 238055 N/A
APOC2 apolipoprotein C-II Mouse Direct Regulation 11813 Q05020
APOC3 apolipoprotein C-III Mouse Direct Regulation 11814 P33622
Apol7a apolipoprotein L 7a Mouse Direct Regulation 75761 B2RT54
APOM apolipoprotein M Mouse Direct Regulation 55938 Q9Z1R3
AQP3 aquaporin 3 Mouse Direct Regulation 11828 Q8R2N1
ARHGAP24 Rho GTPase activating protein 24 Mouse Direct Regulation 231532 Q8C4V1
B230340J04Rik RIKEN cDNA B230340J04 gene Mouse Direct Regulation 320703 N/A
BC002189 cDNA sequence BC002189 Mouse Direct Regulation 620316 N/A
BC030500 cDNA sequence BC030500 Mouse Direct Regulation 234290 Q8K0R8
Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b Mouse Direct Regulation 12045 Q497M6
BTLA B and T lymphocyte associated Mouse Direct Regulation 208154 Q7TSA3
CABP7 calcium binding protein 7 Mouse Direct Regulation 192650 Q91ZM8
Calm4 calmodulin 4 Mouse Direct Regulation 80796 Q9JM83
CCDC54 coiled-coil domain containing 54 Mouse Direct Regulation 69339 Q9DAL3
CD5L CD5 antigen-like Mouse Direct Regulation 11801 Q9QWK4
CDCP2 CUB domain containing protein 2 Mouse Direct Regulation 242603 Q8BQH6
CFI complement component factor i Mouse Direct Regulation 12630 Q61129
CHDH choline dehydrogenase Mouse Direct Regulation 218865 Q8BJ64
CHRD chordin Human Protein Binding 8646 Q8N2W7
CIDEC cell death-inducing DFFA-like effector c Mouse Direct Regulation 14311 P56198
COLEC10 collectin sub-family member 10 Mouse Direct Regulation 239447 Q8CF98
CREB3L3 cAMP responsive element binding protein 3-like 3 Mouse Direct Regulation 208677 Q91XE9
CRYBA2 crystallin, beta A2 Mouse Direct Regulation 12958 Q9JJV1
CRYBB1 crystallin, beta B1 Mouse Direct Regulation 12960 Q9WVJ5
CTSH cathepsin H Mouse Direct Regulation 13036 P49935
CTXN3 cortexin 3 Mouse Direct Regulation 629147 Q8BXZ0
CXCL5 chemokine (C-X-C motif) ligand 5 Mouse Direct Regulation 20311 P50228
Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 Mouse Direct Regulation 13113 Q64464
D10Bwg1379e DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed Mouse Direct Regulation 215821 Q3UGY8
DBX1 developing brain homeobox 1 Mouse Direct Regulation 13172 P52950
DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked Mouse Direct Regulation 26900 Q62095
DEPDC5 DEP domain containing 5 Mouse Direct Regulation 277854 P61460
DFNA5 deafness, autosomal dominant 5 (human) Mouse Direct Regulation 54722 Q9Z2D3
DMKN dermokine Mouse Direct Regulation 73712 Q6P253
DNER delta/notch-like EGF-related receptor Mouse Direct Regulation 227325 Q8JZM4
DSCR6 ripply3 homolog (zebrafish) Mouse Direct Regulation 170765 Q924S9
E030042N06Rik RIKEN cDNA E030042N06 gene Mouse Direct Regulation 319728 N/A
Ear6 eosinophil-associated, ribonuclease A family, member 6 Mouse Direct Regulation 93719 Q923L7
EDN2 endothelin 2 Mouse Direct Regulation 13615 P22389
Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Mouse Direct Regulation 26908 Q9Z0N2
Erv3 endogenous retroviral sequence 3 Mouse Direct Regulation 71995 Q9DAX3
F2 coagulation factor II Mouse Direct Regulation 14061 P19221
FAM65C family with sequence similarity 65, member C Mouse Direct Regulation 69553 A1L3T7
Fbxw21 F-box and WD-40 domain protein 21 Mouse Direct Regulation 320082 Q8BI38
FGG fibrinogen gamma chain Mouse Direct Regulation 99571 Q8VCM7
GABRG1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mouse Direct Regulation 14405 Q9R0Y8
GATA1 GATA binding protein 1 (globin transcription factor 1) Human Protein Binding 2623 P15976
GDA guanine deaminase Mouse Direct Regulation 14544 Q9R111
Gm15623 predicted gene 15623 Mouse Direct Regulation 100040211 N/A
Gm9961 predicted gene 9961 Mouse Direct Regulation 791359 N/A
GP9 glycoprotein IX (platelet) Human Protein Binding 2815 P14770
GPR171 G protein-coupled receptor 171 Mouse Direct Regulation 229323 Q8BG55
GUCA2A guanylate cyclase activator 2a (guanylin) Mouse Direct Regulation 14915 P33680
HAVCR1 hepatitis A virus cellular receptor 1 Mouse Direct Regulation 171283 Q5QNS5
Hbb-bh1 hemoglobin Z, beta-like embryonic chain Mouse Direct Regulation 15132 P04444
HNF1B HNF1 homeobox B Mouse Direct Regulation 21410 P27889
HNF4A hepatic nuclear factor 4, alpha Mouse Direct Regulation 15378 P49698
HOXB1 homeobox B1 Mouse Direct Regulation 15407 P17919
HSPB7 heat shock protein family, member 7 (cardiovascular) Mouse Direct Regulation 29818 P35385
Ifi203 interferon activated gene 203 Mouse Direct Regulation 15950 O35368
Ifi27l2b interferon, alpha-inducible protein 27 like 2B Mouse Direct Regulation 217845 Q8VC49
IGFBP1 insulin-like growth factor binding protein 1 Mouse Direct Regulation 16006 P47876
IGLL1 immunoglobulin lambda-like polypeptide 1 Mouse Direct Regulation 16136 P20764
IL2RB interleukin 2 receptor, beta chain Mouse Direct Regulation 16185 P16297
KCNJ1 potassium inwardly-rectifying channel, subfamily J, member 1 Mouse Direct Regulation 56379 O88335
KDM5D lysine (K)-specific demethylase 5D Mouse Direct Regulation 20592 Q62240
KLB klotho beta Mouse Direct Regulation 83379 Q99N32
KLHL14 kelch-like 14 (Drosophila) Mouse Direct Regulation 225266 Q69ZK5
KRTAP10-1 keratin associated protein 10-1 Human Protein Binding 386677 P60331
KRTAP10-11 keratin associated protein 10-11 Human Protein Binding 386678 P60411
KRTAP10-3 keratin associated protein 10-3 Human Protein Binding 386682 P60369
KRTAP10-5 keratin associated protein 10-5 Human Protein Binding 386680 P60370
KRTAP10-8 keratin associated protein 10-8 Human Protein Binding 386681 P60410
KRTAP10-9 keratin associated protein 10-9 Human Protein Binding 386676 P60411
KRTAP12-1 keratin associated protein 12-1 Human Protein Binding 353332 P59990
KRTAP12-2 keratin associated protein 12-2 Human Protein Binding 353323 P59991
KRTAP12-4 keratin associated protein 12-4 Human Protein Binding 386684 P60329
KRTAP26-1 keratin associated protein 26-1 Human Protein Binding 388818 Q6PEX3
KRTAP3-2 keratin associated protein 3-2 Human Protein Binding 83897 Q9BYR7
KRTAP4-11 keratin associated protein 4-11 Human Protein Binding 653240 Q9BYQ6
KRTAP4-12 keratin associated protein 4-12 Human Protein Binding 83755 Q9BQ66
KRTAP4-7 keratin associated protein 4-7 Human Protein Binding 100132476 Q9BYR0
KRTAP5-6 keratin associated protein 5-6 Human Protein Binding 440023 Q6L8G9
KRTAP5-9 keratin associated protein 5-9 Human Protein Binding 3846 P26371
KRTAP9-2 keratin associated protein 9-2 Human Protein Binding 83899 Q9BYQ4
KRTAP9-4 keratin associated protein 9-4 Human Protein Binding 85280 Q9BYQ2
LCE1B late cornified envelope 1B Human Protein Binding 353132 Q5T7P3
LCE3E late cornified envelope 3E Human Protein Binding 353145 Q5T5B0
LCE4A late cornified envelope 4A Human Protein Binding 199834 Q5TA78
LEFTY1 left right determination factor 1 Mouse Direct Regulation 13590 Q64280
LEFTY2 left-right determination factor 2 Mouse Direct Regulation 320202 P57785
LGALS13 lectin, galactoside-binding, soluble, 13 Human Protein Binding 29124 Q9UHV8
LGALS2 lectin, galactose-binding, soluble 2 Mouse Direct Regulation 107753 Q9CQW5
LHFPL1 lipoma HMGIC fusion partner-like 1 Mouse Direct Regulation 237091 Q80SV1
LOC433461 uncharacterized LOC433461 Mouse Direct Regulation 433461 N/A
LRRC19 leucine rich repeat containing 19 Mouse Direct Regulation 100061 Q8BZT5
LRRC39 leucine rich repeat containing 39 Mouse Direct Regulation 109245 Q8BGI7
LRRC4 leucine rich repeat containing 4 Mouse Direct Regulation 192198 Q99PH1
MAFB v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) Mouse Direct Regulation 16658 P54841
MS4A4B membrane-spanning 4-domains, subfamily A, member 4B Mouse Direct Regulation 60361 Q9ES61
MUC13 mucin 13, epithelial transmembrane Mouse Direct Regulation 17063 P19467
MYBPC3 myosin binding protein C, cardiac Mouse Direct Regulation 17868 O70468
MYH4 myosin, heavy polypeptide 4, skeletal muscle Mouse Direct Regulation 17884 Q5SX39
MYO15B myosin XVB Mouse Direct Regulation 217328 N/A
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5 Mouse Direct Regulation 595136 Q99LY9
NEURL1B neuralized homolog 1b (Drosophila) Mouse Direct Regulation 240055 Q0MW30
NMU neuromedin U Mouse Direct Regulation 56183 Q9QXK8
NODAL nodal Mouse Direct Regulation 18119 P43021
NRK Nik related kinase Mouse Direct Regulation 27206 Q9R0G8
Olfr1223 olfactory receptor 1223 Mouse Direct Regulation 258894 A3KGY4
Olfr181 olfactory receptor 181 Mouse Direct Regulation 259001 Q8VGQ7
Olfr350 olfactory receptor 350 Mouse Direct Regulation 258620 Q8VFP8
Olfr476 olfactory receptor 476 Mouse Direct Regulation 258926 Q8VGI4
Olfr732 olfactory receptor 732 Mouse Direct Regulation 258659 Q8VFT5
Olfr830 olfactory receptor 830 Mouse Direct Regulation 258559 Q8VFJ5
Olfr951 olfactory receptor 951 Mouse Direct Regulation 258046 Q9EQ94
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 Mouse Direct Regulation 108078 Q9EQ09
OPRK1 opioid receptor, kappa 1 Mouse Direct Regulation 18387 P33534
OSMR oncostatin M receptor Mouse Direct Regulation 18414 O70458
PDE11A phosphodiesterase 11A Mouse Direct Regulation 241489 P0C1Q2
PDE1C phosphodiesterase 1C Mouse Direct Regulation 18575 Q64338
PLA2G12B phospholipase A2, group XIIB Mouse Direct Regulation 69836 Q99P27
Prl2c3 prolactin family 2, subfamily c, member 3 Mouse Direct Regulation 18812 P18918
Prl3d1 prolactin family 3, subfamily d, member 1 Mouse Direct Regulation 18775 P18121
Prl4a1 prolactin family 4, subfamily a, member 1 Mouse Direct Regulation 19110 O35256
Prl6a1 prolactin family 6, subfamily a, member 1 Mouse Direct Regulation 19111 O35257
Prl7d1 prolactin family 7, subfamily d, member 1 Mouse Direct Regulation 18814 P04769
PRR15 proline rich 15 Mouse Direct Regulation 78004 Q9D1T5
PVRL4 poliovirus receptor-related 4 Mouse Direct Regulation 71740 Q8R007
RARG retinoic acid receptor, gamma Mouse DNA Binding 19411 P18911
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 Mouse Direct Regulation 109222 J3QNI9
RASGEF1C RasGEF domain family, member 1C Mouse Direct Regulation 74563 Q9D300
RBMY1A1 RNA binding motif protein, Y chromosome, family 1, member A1 Mouse Direct Regulation 19657 O35698
RBPMS RNA binding protein with multiple splicing Human Protein Binding 11030 Q93062
RGS20 regulator of G-protein signaling 20 Human Protein Binding 8601 O76081
RSAD2 radical S-adenosyl methionine domain containing 2 Mouse Direct Regulation 58185 Q8CBB9
Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a Mouse Direct Regulation 66222 Q9D154
SERPIND1 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mouse Direct Regulation 15160 P49182
SHISA3 shisa homolog 3 (Xenopus laevis) Mouse Direct Regulation 330096 Q3UPR0
SLC23A3 solute carrier family 23 (nucleobase transporters), member 3 Mouse Direct Regulation 22626 Q60850
SLC5A11 solute carrier family 5 (sodium/glucose cotransporter), member 11 Mouse Direct Regulation 233836 Q8K0E3
SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Mouse Direct Regulation 50934 Q9QXW9
SLITRK1 SLIT and NTRK-like family, member 1 Mouse Direct Regulation 76965 Q810C1
SOAT2 sterol O-acyltransferase 2 Mouse Direct Regulation 223920 O88908
SPP2 secreted phosphoprotein 2 Mouse Direct Regulation 75396 Q8K1I3
TBC1D10C TBC1 domain family, member 10C Human Protein Binding 374403 Q8IV04
TBX15 T-box 15 Mouse Direct Regulation 21384 O70306
TDH L-threonine dehydrogenase Mouse Direct Regulation 58865 Q8K3F7
TFAP2B transcription factor AP-2 beta Mouse Direct Regulation 21419 Q61313
Timd2 T cell immunoglobulin and mucin domain containing 2 Mouse Direct Regulation 171284 Q8R183
TINAG tubulointerstitial nephritis antigen Mouse Direct Regulation 26944 Q9WUR0
TINAGL1 tubulointerstitial nephritis antigen-like 1 Mouse Direct Regulation 94242 Q99JR5
TLL1 tolloid-like Mouse Direct Regulation 21892 Q62381
TMEM216 transmembrane protein 216 Mouse Direct Regulation 68642 Q9CQC4
TRAPPC6A trafficking protein particle complex 6A Human Protein Binding 79090 O75865
Trim30a tripartite motif-containing 30A Mouse Direct Regulation 20128 P15533
TRIML1 tripartite motif family-like 1 Mouse Direct Regulation 244448 Q8BVP1
TTR transthyretin Mouse Direct Regulation 22139 P07309
Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B Mouse Direct Regulation 394435 K9J7B2
UTY ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome Mouse Direct Regulation 22290 P79457
Vmn1r181 vomeronasal 1 receptor 181 Mouse Direct Regulation 404289 Q0P547
Vmn1r82 vomeronasal 1 receptor 82 Mouse Direct Regulation 171268 Q8R283
Wfdc6a WAP four-disulfide core domain 6A Mouse Direct Regulation 209351 Q3UW55
WNT10B wingless related MMTV integration site 10b Mouse Direct Regulation 22410 P48614
YAP Transcriptional coactivator YAP1 Human DNA Binding 10413 P46937
Zfp60 zinc finger protein 60 Mouse Direct Regulation 22718 P16374
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