Genetic Animal Models / ADNP

ADNP Activity-dependent neuroprotector homeobox

Model Species
Mus musculus
Gene Aliases
AA589558; mKIAA0784
Reports
6
Associated Human Genes
ADNP
Models / Rescue Models
9 / 3
Rescue Model
-
Model Summary

The ADNP homozygous knock out causes embryonic lethality. The heterozygous mice have normal, slightly delayed development and show reduced neuronal survival and some changes in gene expression (e.g., some transcription factors like Pax6).

External Links
Reports related to ADNP (6 Reports)
# Type Title Author, Year
1 Additional Activity-dependent neuroprotective protein: a novel gene essential for brain formation. Pinhasov A , et al. (2003)
2 Primary Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. Vulih-Shultzman I , et al. (2007)
3 Additional Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. Vulih-Shultzman I , et al. (2007)
4 Additional Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies. Malishkevich A , et al. (2015)
5 Additional Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory. Amram N , et al. (2016)
6 Additional Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. Hacohen-Kleiman G , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

M_ADNP_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Exons 3,4 and 5 of the Adnp gene were replaced with a neomycin cassette and a thymidine kinase gene, using homologous recombination. Following germline transmission the hetereozygous knockouts were crossed to generate homozygous mice.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6

Es cell line: 129/Sv
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Pinhasov A , et al. (2003)
Circadian sleep/wake cycle - Not Reported - - Pinhasov A , et al. (2003)
Communications - Not Reported - - Pinhasov A , et al. (2003)
Developmental profile Mortality/lethality: embryonic Increased Survival analysis; Histology E8-E9.5 Pinhasov A , et al. (2003)
Emotion - Not Reported - - Pinhasov A , et al. (2003)
Homeostasis - Not Reported - - Pinhasov A , et al. (2003)
Immune response - Not Reported - - Pinhasov A , et al. (2003)
Learning & memory - Not Reported - - Pinhasov A , et al. (2003)
Maternal behavior - Not Reported - - Pinhasov A , et al. (2003)
Molecular profile Gene expression Abnormal In situ hybridization (ISH) E8-E8.5 Pinhasov A , et al. (2003)
Motor phenotype - Not Reported - - Pinhasov A , et al. (2003)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Pinhasov A , et al. (2003)
Neurophysiology - Not Reported - - Pinhasov A , et al. (2003)
Repetitive behavior - Not Reported - - Pinhasov A , et al. (2003)
Seizure - Not Reported - - Pinhasov A , et al. (2003)
Sensory - Not Reported - - Pinhasov A , et al. (2003)
Social behavior - Not Reported - - Pinhasov A , et al. (2003)

M_ADNP_1_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The knock out model was generated by replacing exons 3,4 and 5 with a neomycin cassette and adding a thymidine kinase gene at the negative selection marker.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Amram N , et al. (2016)
- - Not Reported - - Vulih-Shultzman I , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Amram N , et al. (2016)
Circadian sleep/wake cycle - Not Reported - - Vulih-Shultzman I , et al. (2007)
Communications - Not Reported - - Amram N , et al. (2016)
Communications - Not Reported - - Vulih-Shultzman I , et al. (2007)
Developmental profile - Not Reported - - Amram N , et al. (2016)
Developmental profile Mortality/lethality No Change General observations 0-9 weeks Vulih-Shultzman I , et al. (2007)
Developmental profile Developmental trajectory Decreased Histology E9-15 Vulih-Shultzman I , et al. (2007)
Emotion - Not Reported - - Amram N , et al. (2016)
Emotion - Not Reported - - Vulih-Shultzman I , et al. (2007)
Homeostasis - Not Reported - - Amram N , et al. (2016)
Homeostasis - Not Reported - - Vulih-Shultzman I , et al. (2007)
Immune response - Not Reported - - Amram N , et al. (2016)
Immune response - Not Reported - - Vulih-Shultzman I , et al. (2007)
Learning & memory Olfactory learning and memory No Change Olfactory habituation-dishabituation test 8 months Amram N , et al. (2016)
Learning & memory Spatial working memory Decreased Morris water maze test: modified paradigm 2, 9 months Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial reference memory Decreased Morris water maze test: modified paradigm 2, 9 months Vulih-Shultzman I , et al. (2007)
Maternal behavior - Not Reported - - Amram N , et al. (2016)
Maternal behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Molecular profile Protein expression: In situ protein expression Decreased Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Increased Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Increased Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Decreased Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Targeted protein expression Decreased Western blot: Adnp protein; Quantitative PCR (qRT-PCR) 2, 9 months Vulih-Shultzman I , et al. (2007)
Molecular profile Protein phosphorylation Increased Western blot: Phosphorylated Tau protein 2, 9 months Vulih-Shultzman I , et al. (2007)
Molecular profile Protein phosphorylation Increased Western blot: active GSK3/-pTyr279/216 2, 9 months Vulih-Shultzman I , et al. (2007)
Motor phenotype - Not Reported - - Amram N , et al. (2016)
Motor phenotype Swimming ability No Change Morris water maze test: visible platform 9 months Vulih-Shultzman I , et al. (2007)
Motor phenotype Swimming ability Decreased Morris water maze test: visible platform 2 months Vulih-Shultzman I , et al. (2007)
Motor phenotype General locomotor activity No Change Open field test 2 months Vulih-Shultzman I , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amram N , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Increased Immunohistochemistry 10-11 months Vulih-Shultzman I , et al. (2007)
Neurophysiology Cytoskeletal organization: neuronal: axonal transport Decreased Manganese-enhanced magnetic resonance imaging (MEMRI) 5 months Amram N , et al. (2016)
Neurophysiology - Not Reported - - Vulih-Shultzman I , et al. (2007)
Repetitive behavior - Not Reported - - Amram N , et al. (2016)
Repetitive behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Seizure - Not Reported - - Amram N , et al. (2016)
Seizure - Not Reported - - Vulih-Shultzman I , et al. (2007)
Sensory - Not Reported - - Amram N , et al. (2016)
Sensory - Not Reported - - Vulih-Shultzman I , et al. (2007)
Social behavior Social memory Decreased Three-chamber social approach test 8 months Amram N , et al. (2016)
Social behavior Social approach No Change Three-chamber social approach test 8 months Amram N , et al. (2016)
Social behavior Social memory Decreased Reciprocal social interaction test Unreported Vulih-Shultzman I , et al. (2007)
Social behavior Social interaction: opposite sex Decreased Reciprocal social interaction test Unreported Vulih-Shultzman I , et al. (2007)

M_ADNP_1_KO_HT_NAP-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Heterozygous knockout mice were treated with NAP (peptide: NAPVSIPQ; Allon Therapeutics Inc.), new born mice were injected every day for 2 weeks, subcutaneously as follows: 20 ul (0.5 g of NAP per mouse, days 1-4); 40 ul (1 g of NAP per mouse, days 5-10) ; 80 ul (2 g per mouse, days 11-14). Mice were tested at the age of 2 months in behavioral assessment.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Vulih-Shultzman I , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Vulih-Shultzman I , et al. (2007)
Communications - Not Reported - - Vulih-Shultzman I , et al. (2007)
Developmental profile - Not Reported - - Vulih-Shultzman I , et al. (2007)
Emotion - Not Reported - - Vulih-Shultzman I , et al. (2007)
Homeostasis - Not Reported - - Vulih-Shultzman I , et al. (2007)
Immune response - Not Reported - - Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial working memory Ameliorated Morris water maze test: modified paradigm 2 months Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial reference memory Ameliorated Morris water maze test: modified paradigm 2 months Vulih-Shultzman I , et al. (2007)
Maternal behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Molecular profile Protein phosphorylation Ameliorated Western blot: Phosphorylated Tau protein 2 months Vulih-Shultzman I , et al. (2007)
Molecular profile Protein phosphorylation Ameliorated Western blot: active GSK3/-pTyr279/216 2 months Vulih-Shultzman I , et al. (2007)
Motor phenotype Swimming ability Refractory Morris water maze test: visible platform 2 months Vulih-Shultzman I , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Vulih-Shultzman I , et al. (2007)
Neurophysiology - Not Reported - - Vulih-Shultzman I , et al. (2007)
Repetitive behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Seizure - Not Reported - - Vulih-Shultzman I , et al. (2007)
Sensory - Not Reported - - Vulih-Shultzman I , et al. (2007)
Social behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)

M_ADNP_1_KO_HT_NAP-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

The heterozygous knock out mice were treated with NAP (peptide: NAPVSIPQ; Allon Therapeutics Inc.) intranasally at 0.5 g/5 ul per mouse for 2 weeks at the age of 2 months. The testing commenced during the second week of treatment, starting 1 hr after administration of NAP.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Vulih-Shultzman I , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Vulih-Shultzman I , et al. (2007)
Communications - Not Reported - - Vulih-Shultzman I , et al. (2007)
Developmental profile - Not Reported - - Vulih-Shultzman I , et al. (2007)
Emotion - Not Reported - - Vulih-Shultzman I , et al. (2007)
Homeostasis - Not Reported - - Vulih-Shultzman I , et al. (2007)
Immune response - Not Reported - - Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial working memory Ameliorated Morris water maze test: modified paradigm 2 months Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial reference memory Ameliorated Morris water maze test: modified paradigm 2 months Vulih-Shultzman I , et al. (2007)
Maternal behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Molecular profile - Not Reported - - Vulih-Shultzman I , et al. (2007)
Motor phenotype - Not Reported - - Vulih-Shultzman I , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Vulih-Shultzman I , et al. (2007)
Neurophysiology - Not Reported - - Vulih-Shultzman I , et al. (2007)
Repetitive behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Seizure - Not Reported - - Vulih-Shultzman I , et al. (2007)
Sensory - Not Reported - - Vulih-Shultzman I , et al. (2007)
Social behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)

M_ADNP_1_KO_HT_NAP-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

These mice were treated with NAP (peptide: NAPVSIPQ; Allon Therapeutics Inc.) twice, once after birth (tested at 2 months) and the second time at 9 months of age. The first treatment with NAP was in newborn mice, every day for 2 weeks, s.c. of 20 ul (0.5 g of NAP per mouse, days 1-4); 40 ul (1 g of NAP per mouse, days 5-10) ; 80u l (2 g per mouse, days 11-14). Following that, the same mice were treated with NAP at 9 months of age , intranasally for 2 weeks. The testing commenced during the second week of treatment, starting 1 hr after administration of NAP.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Vulih-Shultzman I , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Vulih-Shultzman I , et al. (2007)
Communications - Not Reported - - Vulih-Shultzman I , et al. (2007)
Developmental profile - Not Reported - - Vulih-Shultzman I , et al. (2007)
Emotion - Not Reported - - Vulih-Shultzman I , et al. (2007)
Homeostasis - Not Reported - - Vulih-Shultzman I , et al. (2007)
Immune response - Not Reported - - Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial working memory Ameliorated Morris water maze test: modified paradigm 9 months Vulih-Shultzman I , et al. (2007)
Learning & memory Spatial reference memory Ameliorated Morris water maze test: modified paradigm 9 months Vulih-Shultzman I , et al. (2007)
Maternal behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Molecular profile - Not Reported - - Vulih-Shultzman I , et al. (2007)
Motor phenotype - Not Reported - - Vulih-Shultzman I , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Vulih-Shultzman I , et al. (2007)
Neurophysiology - Not Reported - - Vulih-Shultzman I , et al. (2007)
Repetitive behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)
Seizure - Not Reported - - Vulih-Shultzman I , et al. (2007)
Sensory - Not Reported - - Vulih-Shultzman I , et al. (2007)
Social behavior - Not Reported - - Vulih-Shultzman I , et al. (2007)

M_ADNP_1_KO_HT_SKIP-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Adnp het mice (5 months) were injected (i.p.) with 10ug/0.3 ml saline of SKIP- a four amino acid peptide derived from NAP that binds EB1/EB3 proteins (microtubule end binding proteins), prior to analysis in manganese enhanced MRI (MEMRI), these mice and the control group also inhaled 4 ul of 0.5 n manganese chloride solution (in PBS) through EACH nostril for preparation for MEMRI.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Amram N , et al. (2016)
Circadian sleep/wake cycle - Not Reported - - Amram N , et al. (2016)
Communications - Not Reported - - Amram N , et al. (2016)
Developmental profile - Not Reported - - Amram N , et al. (2016)
Emotion - Not Reported - - Amram N , et al. (2016)
Homeostasis - Not Reported - - Amram N , et al. (2016)
Immune response - Not Reported - - Amram N , et al. (2016)
Learning & memory - Not Reported - - Amram N , et al. (2016)
Maternal behavior - Not Reported - - Amram N , et al. (2016)
Molecular profile - Not Reported - - Amram N , et al. (2016)
Motor phenotype - Not Reported - - Amram N , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amram N , et al. (2016)
Neurophysiology Cytoskeletal organization: neuronal: axonal transport Restored Manganese-enhanced magnetic resonance imaging (MEMRI) 5 months Amram N , et al. (2016)
Repetitive behavior - Not Reported - - Amram N , et al. (2016)
Seizure - Not Reported - - Amram N , et al. (2016)
Sensory - Not Reported - - Amram N , et al. (2016)
Social behavior - Not Reported - - Amram N , et al. (2016)

M_ADNP_1_KO_HT_SKIP-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Adnp het mice (6 months) were treated with intranasal (i.n.) administration of 2 ug/5ul of SKIP for 1 month and also 2 hr before behavior testing.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Amram N , et al. (2016)
Circadian sleep/wake cycle - Not Reported - - Amram N , et al. (2016)
Communications - Not Reported - - Amram N , et al. (2016)
Developmental profile - Not Reported - - Amram N , et al. (2016)
Emotion - Not Reported - - Amram N , et al. (2016)
Homeostasis - Not Reported - - Amram N , et al. (2016)
Immune response - Not Reported - - Amram N , et al. (2016)
Learning & memory - Not Reported - - Amram N , et al. (2016)
Maternal behavior - Not Reported - - Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Restored Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Refractory Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Restored Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Molecular profile Protein expression: In situ protein expression Restored Immunohistochemistry: hippocampus 9 months Amram N , et al. (2016)
Motor phenotype - Not Reported - - Amram N , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amram N , et al. (2016)
Neurophysiology - Not Reported - - Amram N , et al. (2016)
Repetitive behavior - Not Reported - - Amram N , et al. (2016)
Seizure - Not Reported - - Amram N , et al. (2016)
Sensory - Not Reported - - Amram N , et al. (2016)
Social behavior Social memory Restored Three-chamber social approach test 8 months Amram N , et al. (2016)

M_ADNP_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Adnp het knock out mice were maintained in the ICR outbred background to circumvent breding problems. This resulted in more aggressive mice than the inbred background (the authors have noted).

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
- - Not Reported - - Malishkevich A , et al. (2015)
Circadian sleep/wake cycle - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Circadian sleep/wake cycle - Not Reported - - Malishkevich A , et al. (2015)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P8 Hacohen-Kleiman G , et al. (2018)
Communications - Not Reported - - Malishkevich A , et al. (2015)
Developmental profile Size/growth Decreased Body length measurement P0-3 weeks Hacohen-Kleiman G , et al. (2018)
Developmental profile Size/growth Decreased Body weight measurement P0-P21 Hacohen-Kleiman G , et al. (2018)
Developmental profile Developmental trajectory Abnormal Developmental milestone measurements P5-20 Hacohen-Kleiman G , et al. (2018)
Developmental profile - Not Reported - - Malishkevich A , et al. (2015)
Emotion - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Emotion - Not Reported - - Malishkevich A , et al. (2015)
Homeostasis - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Homeostasis - Not Reported - - Malishkevich A , et al. (2015)
Immune response - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Immune response - Not Reported - - Malishkevich A , et al. (2015)
Learning & memory Object recognition memory Decreased Novel object recognition test Adult Hacohen-Kleiman G , et al. (2018)
Learning & memory Olfactory learning and memory No Change Olfactory habituation-dishabituation test 7 months Malishkevich A , et al. (2015)
Learning & memory Object recognition memory Decreased Novel object recognition test 7 months Malishkevich A , et al. (2015)
Maternal behavior - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Maternal behavior - Not Reported - - Malishkevich A , et al. (2015)
Molecular profile Targeted protein expression Decreased Quantitative PCR (qRT-PCR) 2.7-3 weeks Hacohen-Kleiman G , et al. (2018)
Molecular profile Gene expression Abnormal Quantitative PCR (qRT-PCR) 2.7-3 weeks, 3 months Hacohen-Kleiman G , et al. (2018)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR): eIF4E mRNA 7 months Malishkevich A , et al. (2015)
Motor phenotype Motor coordination and balance Decreased Wire hang test 3 weeks Hacohen-Kleiman G , et al. (2018)
Motor phenotype Grip strength Decreased Grip strength test 3 weeks Hacohen-Kleiman G , et al. (2018)
Motor phenotype Gait Decreased Footprint analysis 1 month Hacohen-Kleiman G , et al. (2018)
Motor phenotype General locomotor activity No Change Open field test 5-6 months Malishkevich A , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: synaptic bouton number Increased Immunohistochemistry Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: mature boutons Decreased Immunohistochemistry Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Decreased Immunohistochemistry Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Fluorescence microscopy Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Malishkevich A , et al. (2015)
Neurophysiology - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Neurophysiology - Not Reported - - Malishkevich A , et al. (2015)
Repetitive behavior - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Repetitive behavior - Not Reported - - Malishkevich A , et al. (2015)
Seizure - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Seizure - Not Reported - - Malishkevich A , et al. (2015)
Sensory Olfaction Decreased Olfactory discrimination test Adult Hacohen-Kleiman G , et al. (2018)
Sensory - Not Reported - - Malishkevich A , et al. (2015)
Social behavior Social memory Decreased Social recognition test Adult Hacohen-Kleiman G , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test Adult Hacohen-Kleiman G , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 7-8 months Malishkevich A , et al. (2015)
Social behavior Social approach No Change Three-chamber social approach test 7-8 months Malishkevich A , et al. (2015)

M_ADNP_2_KO_HT_NAP

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Preweaning, mouse pups were subcutaneously administrated NAP (25 microgram/ml saline) for 21 consecutive days in increasing volumes in doses of 20, 40, 80, 120 and 160 microliters on postnatal days 1-4, 5-7, 9-10, 11-14, 15-18 and 19-21 respectively, followed by daily intranasal NAP treatment in vehicle (DD) at 0.5 microgram per 5 microliter, post-weaning at 21 days.

Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Communications Ultrasonic vocalization: Isolation induced Restored Monitoring ultrasonic vocalizations P8 Hacohen-Kleiman G , et al. (2018)
Developmental profile Size/growth Restored Body weight measurement P0-P21 Hacohen-Kleiman G , et al. (2018)
Developmental profile Size/growth Refractory Body length measurement P0-3 weeks Hacohen-Kleiman G , et al. (2018)
Developmental profile Developmental trajectory Ameliorated Developmental milestone measurements P5-20 Hacohen-Kleiman G , et al. (2018)
Emotion - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Homeostasis - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Immune response - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Learning & memory Object recognition memory Restored Novel object recognition test - Hacohen-Kleiman G , et al. (2018)
Maternal behavior - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Molecular profile - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Motor phenotype Motor coordination and balance Restored Wire hang test 3 weeks Hacohen-Kleiman G , et al. (2018)
Motor phenotype Grip strength Restored Grip strength test 3 weeks Hacohen-Kleiman G , et al. (2018)
Motor phenotype Gait Ameliorated Footprint analysis 1 month Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: synaptic bouton number Ameliorated Immunohistochemistry Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: synaptic bouton number Side Effect Immunohistochemistry Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: mature boutons Restored Immunohistochemistry Adult Hacohen-Kleiman G , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Fluorescence microscopy Adult Hacohen-Kleiman G , et al. (2018)
Neurophysiology - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Repetitive behavior - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Seizure - Not Reported - - Hacohen-Kleiman G , et al. (2018)
Sensory Olfaction Restored Olfactory discrimination test Adult Hacohen-Kleiman G , et al. (2018)
Social behavior Social memory Decreased Social recognition test Adult Hacohen-Kleiman G , et al. (2018)
Social behavior Social approach Restored Three-chamber social approach test Adult Hacohen-Kleiman G , et al. (2018)
Other ADNP Rescue Models(3 Models)
M_ADNP_1_KO_HT 3 Genetic Pharmaceutical NAP
M_ADNP_1_KO_HT 2 Genetic Pharmaceutical SKIP
M_ADNP_2_KO_HT 1 Genetic Pharmaceutical NAP
CNVs associated with ADNP(1 Models)
20q13.13 9 Deletion-Duplication 15  /  33
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