ADNP Activity-dependent neuroprotector homeobox
Model Species
Mus musculusGene Aliases
AA589558; mKIAA0784Models / Rescue Models
16 / 6Rescue Model
-Model Summary
The ADNP homozygous knock out causes embryonic lethality. The heterozygous mice have normal, slightly delayed development and show reduced neuronal survival and some changes in gene expression (e.g., some transcription factors like Pax6).
External Links
Reports related to ADNP (10 Reports)
# | Type | Title | Author, Year |
---|---|---|---|
1 | Additional | Activity-dependent neuroprotective protein: a novel gene essential for brain formation. | Pinhasov A , et al. (2003) |
2 | Primary | Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. | Vulih-Shultzman I , et al. (2007) |
3 | Additional | Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. | Vulih-Shultzman I , et al. (2007) |
4 | Additional | Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies. | Malishkevich A , et al. (2015) |
5 | Additional | Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory. | Amram N , et al. (2016) |
6 | Additional | Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. | Hacohen-Kleiman G , et al. (2018) |
7 | Additional | The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse. | Sragovich S , et al. (2019) |
8 | Additional | The autism-mutated ADNP plays a key role in stress response. | Sragovich S , et al. (2019) |
9 | Additional | Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond | Kapitansky O et al. (2020) |
10 | Additional | Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies | Karmon G et al. (2021) |
M_ADNP_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Exons 3,4 and 5 of the Adnp gene were replaced with a neomycin cassette and a thymidine kinase gene, using homologous recombination. Following germline transmission the hetereozygous knockouts were crossed to generate homozygous mice.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6
Es cell line: 129/Sv
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Motor phenotype | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Neurophysiology | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Repetitive behavior | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Seizure | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Sensory | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Social behavior | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Physiological parameters | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Communications | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Developmental profile | Mortality/lethality: embryonic | Increased | Survival analysis | E8-e9.5 | Pinhasov A , et al. (2003) |
Developmental profile | Mortality/lethality: embryonic | Increased | Histology | E8-e9.5 | Pinhasov A , et al. (2003) |
Emotion | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Immune response | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Learning & memory | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Maternal behavior | NA | Not reported | NA | NA | Pinhasov A , et al. (2003) |
Molecular profile | Gene expression | Abnormal | In situ hybridization (ish) | E8-e8.5 | Pinhasov A , et al. (2003) |
M_ADNP_1_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
The knock out model was generated by replacing exons 3,4 and 5 with a neomycin cassette and adding a thymidine kinase gene at the negative selection marker.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Motor phenotype | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Motor phenotype | Swimming ability | No change | Morris water maze test | 9 months | Vulih-Shultzman I , et al. (2007) |
Motor phenotype | Swimming ability | Decreased | Morris water maze test | 2 months | Vulih-Shultzman I , et al. (2007) |
Motor phenotype | General locomotor activity | No change | Open field test | 2 months | Vulih-Shultzman I , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Increased | Immunohistochemistry | 10-11 months | Vulih-Shultzman I , et al. (2007) |
Neurophysiology | Cytoskeletal organization: neuronal: axonal transport | Decreased | Manganese-enhanced magnetic resonance imaging (memri) | 5 months | Amram N , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 8 months | Amram N , et al. (2016) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8 months | Amram N , et al. (2016) |
Social behavior | Social memory | Decreased | Reciprocal social interaction test | Unreported | Vulih-Shultzman I , et al. (2007) |
Social behavior | Social interaction: opposite sex | Decreased | Reciprocal social interaction test | Unreported | Vulih-Shultzman I , et al. (2007) |
Physiological parameters | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Communications | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Communications | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Developmental profile | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Developmental profile | Mortality/lethality | No change | General observations | 0-9 weeks | Vulih-Shultzman I , et al. (2007) |
Developmental profile | Developmental trajectory | Decreased | Histology | E9-15 | Vulih-Shultzman I , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Olfactory learning and memory | No change | Olfactory habituation-dishabituation test | 8 months | Amram N , et al. (2016) |
Learning & memory | Spatial working memory | Decreased | Morris water maze test | 2, 9 months | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial reference memory | Decreased | Morris water maze test | 2, 9 months | Vulih-Shultzman I , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Molecular profile | Protein expression: in situ protein expression | Decreased | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Increased | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Increased | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Decreased | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Targeted expression | Decreased | Western blot | 2, 9 months | Vulih-Shultzman I , et al. (2007) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | 2, 9 months | Vulih-Shultzman I , et al. (2007) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 2, 9 months | Vulih-Shultzman I , et al. (2007) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 2, 9 months | Vulih-Shultzman I , et al. (2007) |
M_ADNP_1_KO_HT_NAP-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Heterozygous knockout mice were treated with NAP (peptide: NAPVSIPQ; Allon Therapeutics Inc.), new born mice were injected every day for 2 weeks, subcutaneously as follows: 20 ul (0.5 g of NAP per mouse, days 1-4); 40 ul (1 g of NAP per mouse, days 5-10) ; 80 ul (2 g per mouse, days 11-14). Mice were tested at the age of 2 months in behavioral assessment.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Motor phenotype | Swimming ability | Refractory | Morris water maze test | 2 months | Vulih-Shultzman I , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Neurophysiology | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Social behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Physiological parameters | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Communications | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Developmental profile | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial working memory | Ameliorated | Morris water maze test | 2 months | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial reference memory | Ameliorated | Morris water maze test | 2 months | Vulih-Shultzman I , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Molecular profile | Protein phosphorylation | Ameliorated | Western blot | 2 months | Vulih-Shultzman I , et al. (2007) |
Molecular profile | Protein phosphorylation | Ameliorated | Western blot | 2 months | Vulih-Shultzman I , et al. (2007) |
M_ADNP_1_KO_HT_NAP-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
The heterozygous knock out mice were treated with NAP (peptide: NAPVSIPQ; Allon Therapeutics Inc.) intranasally at 0.5 g/5 ul per mouse for 2 weeks at the age of 2 months. The testing commenced during the second week of treatment, starting 1 hr after administration of NAP.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Motor phenotype | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Neurophysiology | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Social behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Physiological parameters | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Communications | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Developmental profile | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial working memory | Ameliorated | Morris water maze test | 2 months | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial reference memory | Ameliorated | Morris water maze test | 2 months | Vulih-Shultzman I , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Molecular profile | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
M_ADNP_1_KO_HT_NAP-3
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
These mice were treated with NAP (peptide: NAPVSIPQ; Allon Therapeutics Inc.) twice, once after birth (tested at 2 months) and the second time at 9 months of age. The first treatment with NAP was in newborn mice, every day for 2 weeks, s.c. of 20 ul (0.5 g of NAP per mouse, days 1-4); 40 ul (1 g of NAP per mouse, days 5-10) ; 80u l (2 g per mouse, days 11-14). Following that, the same mice were treated with NAP at 9 months of age , intranasally for 2 weeks. The testing commenced during the second week of treatment, starting 1 hr after administration of NAP.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Motor phenotype | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Neurophysiology | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Social behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Physiological parameters | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Communications | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Developmental profile | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial working memory | Ameliorated | Morris water maze test | 9 months | Vulih-Shultzman I , et al. (2007) |
Learning & memory | Spatial reference memory | Ameliorated | Morris water maze test | 9 months | Vulih-Shultzman I , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
Molecular profile | NA | Not reported | NA | NA | Vulih-Shultzman I , et al. (2007) |
M_ADNP_1_KO_HT_SKIP-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Adnp het mice (5 months) were injected (i.p.) with 10ug/0.3 ml saline of SKIP- a four amino acid peptide derived from NAP that binds EB1/EB3 proteins (microtubule end binding proteins), prior to analysis in manganese enhanced MRI (MEMRI), these mice and the control group also inhaled 4 ul of 0.5 n manganese chloride solution (in PBS) through EACH nostril for preparation for MEMRI.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Neurophysiology | Cytoskeletal organization: neuronal: axonal transport | Restored | Manganese-enhanced magnetic resonance imaging (memri) | 5 months | Amram N , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Communications | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Amram N , et al. (2016) |
M_ADNP_1_KO_HT_SKIP-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Adnp het mice (6 months) were treated with intranasal (i.n.) administration of 2 ug/5ul of SKIP for 1 month and also 2 hr before behavior testing.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Social behavior | Social memory | Restored | Three-chamber social approach test | 8 months | Amram N , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Communications | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Restored | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Refractory | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Restored | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
Molecular profile | Protein expression: in situ protein expression | Restored | Immunohistochemistry | 9 months | Amram N , et al. (2016) |
M_ADNP_2_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Adnp het knock out mice were maintained in the ICR outbred background to circumvent breding problems. This resulted in more aggressive mice than the inbred background (the authors have noted).
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 9-12 months | Sragovich S , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 9-12 months | Sragovich S , et al. (2019) |
Motor phenotype | Motor coordination and balance | Decreased | Wire hang test | 3-6 months | Sragovich S , et al. (2019) |
Motor phenotype | Motor coordination and balance | Decreased | Wire hang test | 3 weeks | Hacohen-Kleiman G , et al. (2018) |
Motor phenotype | Grip strength | Decreased | Grip strength test | 3 weeks | Hacohen-Kleiman G , et al. (2018) |
Motor phenotype | Gait | Decreased | Footprint analysis | 1 month | Hacohen-Kleiman G , et al. (2018) |
Motor phenotype | General locomotor activity | No change | Open field test | 5-6 months | Malishkevich A , et al. (2015) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: excitatory neurons | Decreased | Immunohistochemistry | 7.5 month | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Increased | Diffusion tensor imaging (dti) | 7-8 months | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dti: fractional anisotropy or relative anisotropy in brain regions | Decreased | Diffusion tensor imaging (dti) | 7-8 months | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: synaptic bouton number | Increased | Immunohistochemistry | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: mature boutons | Decreased | Immunohistochemistry | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Decreased | Immunohistochemistry | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Decreased | Fluorescence microscopy | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Neurophysiology | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Repetitive behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Repetitive behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Repetitive behavior | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Seizure | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Sensory | Olfaction | No change | Olfactory discrimination test | 9-12 months | Sragovich S , et al. (2019) |
Sensory | Olfaction | Decreased | Olfactory discrimination test | 3-6 months | Sragovich S , et al. (2019) |
Sensory | Olfaction | Increased | Olfactory discrimination test | 3-6 months | Sragovich S , et al. (2019) |
Sensory | Olfaction | Decreased | Olfactory discrimination test | Adult | Hacohen-Kleiman G , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social approach | No change | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 3-6 months | Sragovich S , et al. (2019) |
Social behavior | Social approach | No change | Three-chamber social approach test | 3-6 months | Sragovich S , et al. (2019) |
Social behavior | Social memory | Decreased | Social recognition test | Adult | Hacohen-Kleiman G , et al. (2018) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | Adult | Hacohen-Kleiman G , et al. (2018) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 7-8 months | Malishkevich A , et al. (2015) |
Social behavior | Social approach | No change | Three-chamber social approach test | 7-8 months | Malishkevich A , et al. (2015) |
Physiological parameters | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Communications | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Communications | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Communications | Ultrasonic vocalization: isolation induced | Decreased | Monitoring ultrasonic vocalizations | P8 | Hacohen-Kleiman G , et al. (2018) |
Communications | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Developmental profile | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Developmental profile | Size/growth | Decreased | Body length measurement | P0-3 weeks | Hacohen-Kleiman G , et al. (2018) |
Developmental profile | Size/growth | Decreased | Body weight measurement | P0-p21 | Hacohen-Kleiman G , et al. (2018) |
Developmental profile | Developmental trajectory | Abnormal | Developmental milestone measurements | P5-20 | Hacohen-Kleiman G , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Emotion | Anxiety | No change | Elevated plus maze test | 9-12 months | Sragovich S , et al. (2019) |
Emotion | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Emotion | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Immune response | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Learning & memory | Object recognition memory: long-term recall | Decreased | Novel object recognition test | 9-12 months | Sragovich S , et al. (2019) |
Learning & memory | Object recognition memory: long-term recall | No change | Novel object recognition test | 9-12 months | Sragovich S , et al. (2019) |
Learning & memory | Olfactory learning and memory | No change | Olfactory discrimination test | 3-6 months | Sragovich S , et al. (2019) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 3-6 months | Sragovich S , et al. (2019) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | Adult | Hacohen-Kleiman G , et al. (2018) |
Learning & memory | Olfactory learning and memory | No change | Olfactory habituation-dishabituation test | 7 months | Malishkevich A , et al. (2015) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 7 months | Malishkevich A , et al. (2015) |
Maternal behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Malishkevich A , et al. (2015) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | 9-12 months | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 1, 5 months | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 1, 5 months | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 1, 5 months | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 7.5 month | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 7.5 month | Sragovich S , et al. (2019) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | 2.7-3 weeks | Hacohen-Kleiman G , et al. (2018) |
Molecular profile | Gene expression | Abnormal | Quantitative pcr (qrt-pcr) | 2.7-3 weeks, 3 months | Hacohen-Kleiman G , et al. (2018) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 7 months | Malishkevich A , et al. (2015) |
M_ADNP_2_KO_HT_NAP
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Preweaning, mouse pups were subcutaneously administrated NAP (25 microgram/ml saline) for 21 consecutive days in increasing volumes in doses of 20, 40, 80, 120 and 160 microliters on postnatal days 1-4, 5-7, 9-10, 11-14, 15-18 and 19-21 respectively, followed by daily intranasal NAP treatment in vehicle (DD) at 0.5 microgram per 5 microliter, post-weaning at 21 days.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Motor phenotype | Motor coordination and balance | Restored | Wire hang test | 3 weeks | Hacohen-Kleiman G , et al. (2018) |
Motor phenotype | Grip strength | Restored | Grip strength test | 3 weeks | Hacohen-Kleiman G , et al. (2018) |
Motor phenotype | Gait | Ameliorated | Footprint analysis | 1 month | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: synaptic bouton number | Ameliorated | Immunohistochemistry | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: synaptic bouton number | Side effect | Immunohistochemistry | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: mature boutons | Restored | Immunohistochemistry | Adult | Hacohen-Kleiman G , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Fluorescence microscopy | Adult | Hacohen-Kleiman G , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Sensory | Olfaction | Restored | Olfactory discrimination test | Adult | Hacohen-Kleiman G , et al. (2018) |
Social behavior | Social memory | Decreased | Social recognition test | Adult | Hacohen-Kleiman G , et al. (2018) |
Social behavior | Social approach | Restored | Three-chamber social approach test | Adult | Hacohen-Kleiman G , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Communications | Ultrasonic vocalization: isolation induced | Restored | Monitoring ultrasonic vocalizations | P8 | Hacohen-Kleiman G , et al. (2018) |
Developmental profile | Size/growth | Restored | Body weight measurement | P0-p21 | Hacohen-Kleiman G , et al. (2018) |
Developmental profile | Size/growth | Refractory | Body length measurement | P0-3 weeks | Hacohen-Kleiman G , et al. (2018) |
Developmental profile | Developmental trajectory | Ameliorated | Developmental milestone measurements | P5-20 | Hacohen-Kleiman G , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Learning & memory | Object recognition memory | Restored | Novel object recognition test | NA | Hacohen-Kleiman G , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
Molecular profile | NA | Not reported | NA | NA | Hacohen-Kleiman G , et al. (2018) |
M_ADNP_2_KO_HT_NAP-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
3-6 month old male M_ADNP_2_KO_HT_NAP mice were administered NAP labelled with cy 5.0 on the amino terminal end, once daily at 0.5 microgram in 5 microliters for one month. NAP was dissolved in chlorbutanol to increase bioavailability through the blood-brain-barrier.
Allele Type: Targeted (knockout)
Strain of Origin: 129/Sv
Genetic Background: 129/Sv*C57BL/6*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Motor phenotype | Motor coordination and balance | Ameliorated | Wire hang test | 3-6 months | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: excitatory neurons | Restored | Immunohistochemistry | 7.5 month | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Refractory | Diffusion tensor imaging (dti) | 7-8 months | Sragovich S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dti: fractional anisotropy or relative anisotropy in brain regions | Ameliorated | Diffusion tensor imaging (dti) | 7-8 months | Sragovich S , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Repetitive behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Sensory | Olfaction | Restored | Olfactory discrimination test | 3-6 months | Sragovich S , et al. (2019) |
Social behavior | Social memory | Restored | Three-chamber social approach test | 3-6 months | Sragovich S , et al. (2019) |
Social behavior | Social approach | No adverse effect | Three-chamber social approach test | 3-6 months | Sragovich S , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Communications | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Emotion | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Learning & memory | Olfactory learning and memory | No adverse effect | Olfactory discrimination test | 3-6 months | Sragovich S , et al. (2019) |
Learning & memory | Object recognition memory | Restored | Novel object recognition test | 3-6 months | Sragovich S , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | No adverse effect | Quantitative pcr (qrt-pcr) | 7.5 month | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | Refractory | Quantitative pcr (qrt-pcr) | 7.5 month | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | Side effect | Quantitative pcr (qrt-pcr) | 7.5 month | Sragovich S , et al. (2019) |
Molecular profile | Gene expression | Restored | Quantitative pcr (qrt-pcr) | 7.5 month | Sragovich S , et al. (2019) |
M_ADNP_3_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
ADNP exons 3, 4, and 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The mouse model is identical to the construct of model M_ADNP_2_KO_HT but on a different background.
Allele Type: Targeted (knockout)
Strain of Origin: NA
Genetic Background: ICR
Es cell line: NA
Model Source: PMID 30106381 (Hacohen-Kleiman et al. 2018)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Spontaneous movement | Increased | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Motor phenotype | Spontaneous movement | Decreased | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Motor phenotype | General locomotor activity | No change | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Motor phenotype | General locomotor activity | Increased | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Social behavior | Social memory | No change | Three-chamber social approach test | 2.5 months | Kapitansky O et al. (2020) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 2.5 months | Kapitansky O et al. (2020) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 2.5 months | Kapitansky O et al. (2020) |
Social behavior | Social approach | No change | Three-chamber social approach test | 2.5 months | Kapitansky O et al. (2020) |
Physiological parameters | Intestinal microbiota composition | Increased | 16s rrna gene sequence analysis for identification of bacteria | 1.5 months | Kapitansky O et al. (2020) |
Physiological parameters | Intestinal microbiota composition | Abnormal | 16s rrna gene sequence analysis for identification of bacteria | 1.5 months | Kapitansky O et al. (2020) |
Developmental profile | Size/growth | No change | Body weight measurement | 2.5 months | Kapitansky O et al. (2020) |
Developmental profile | Size/growth | Decreased | Body weight measurement | 2.5 months | Kapitansky O et al. (2020) |
Emotion | Anxiety | No change | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Emotion | Anxiety | Decreased | Open field test | 2.5 months | Kapitansky O et al. (2020) |
M_ADNP_3_KO_HT_NAP
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
One month old mutant male and female mice received daily intranasal NAP at 0.5 microgram/5 microL/mouse/dose. Nasal NAP application was performed daily, once a day, for 45 days (5 days a week). After 45 days of treatment, on days of scheduled behavioral tests, NAP was applied 2 h before the test.
Allele Type: Targeted (knockout)
Strain of Origin: NA
Genetic Background: ICR
Es cell line: NA
Model Source: PMID 30106381 (Hacohen-Kleiman et al. 2018)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | General locomotor activity: ambulatory activity | Restored | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Motor phenotype | General locomotor activity | Restored | Open field test | 2.5 months | Kapitansky O et al. (2020) |
Social behavior | Social memory | Restored | Three-chamber social approach test | 2.5 months | Kapitansky O et al. (2020) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 2.5 months | Kapitansky O et al. (2020) |
Physiological parameters | Intestinal microbiota composition | Restored | 16s rrna gene sequence analysis for identification of bacteria | 1.5 months | Kapitansky O et al. (2020) |
Emotion | Anxiety | Restored | Open field test | 2.5 months | Kapitansky O et al. (2020) |
M_ADNP_3_KO_HT_STRESS
Model Type: Multifactorial
Model Genotype: Heterozygous
Mutation:
Adnp heterozygous knockout mice with exons 3, 4 and 5 of the adnp gene replaced with a neomycin cassette and a thymidine kinase gene, are exposed to a stress challenge through 48 hours of solitude in clean cage under constant bright illumination of about 500 lux.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL*129/Sv*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 9-12 months | Sragovich S , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 9-12 months | Sragovich S , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Repetitive behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Sensory | Olfaction | No change | Olfactory discrimination test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Communications | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Emotion | Anxiety | No change | Elevated plus maze test | 9-12 months | Sragovich S , et al. (2019) |
Emotion | Anxiety | Decreased | Elevated plus maze test | 9-12 months | Sragovich S , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Learning & memory | Object recognition memory: long-term recall | Decreased | Novel object recognition test | 9-12 months | Sragovich S , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Molecular profile | Targeted expression | No change | Quantitative pcr (qrt-pcr) | 9-12 months | Sragovich S , et al. (2019) |
M_ADNP_3_KO_HT_STRESS_PACAP
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
912-month-old mice were treated twice daily 5 days a week with PACAP for one month with intranasal administration 5ug/5ul/mouse. In days of scheduled behavioral tests, PACAP was applied once a day, 2 h before the test.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL*129/Sv*ICR
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | No adverse effect | Open field test | 9-12 months | Sragovich S , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | Restored | Open field test | 9-12 months | Sragovich S , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Repetitive behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Sensory | Olfaction | Side effect | Olfactory discrimination test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social memory | Restored | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 9-12 months | Sragovich S , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Communications | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | 9-12 months | Sragovich S , et al. (2019) |
Emotion | Anxiety | Restored | Elevated plus maze test | 9-12 months | Sragovich S , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Learning & memory | Object recognition memory: long-term recall | Restored | Novel object recognition test | 9-12 months | Sragovich S , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Sragovich S , et al. (2019) |
Molecular profile | Targeted expression | No adverse effect | Quantitative pcr (qrt-pcr) | 9-12 months | Sragovich S , et al. (2019) |
M_ADNP_4_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Try model carries the nm_001310086 (adnp_v001) c.2154t>a, p.tyr718* mutation; animals express a truncated adnp protein that lacks the nuclear localization signal
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6NJ
Es cell line: C57BL/6N
Model Source: Karmon et al., 2021
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Righting response | decreased | Righting reflex test | P8-21 | Karmon G et al. (2021) |
Motor phenotype | Motor coordination and balance | no change | Wire hang test | Adult | Karmon G et al. (2021) |
Motor phenotype | Motor coordination and balance | decreased | Wire hang test | Adult | Karmon G et al. (2021) |
Motor phenotype | Gait | abnormal | Running stride analysis | P70 | Karmon G et al. (2021) |
Motor phenotype | Gait | abnormal | Running stride analysis | P70 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Ultrasonic vocalization: isolation induced | abnormal | Spectographic analysis of vocalization recordings | P8 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Ultrasonic vocalization: isolation induced | decreased | Spectographic analysis of vocalization recordings | P8 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | decreased | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Ear twitch reflex or preyer's reflex | increased | Preyer's Reflex test | P7-15 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | decreased | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | no change | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | no change | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | decreased | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Repetitive behavior | Self grooming | increased | Open field test | Adult | Karmon G et al. (2021) |
Sensory | Vision | increased | Cliff avoidance test | P1-14 | Karmon G et al. (2021) |
Sensory | Startle response: acoustic stimulus | decreased | Acoustic startle reflex test | P7-18 | Karmon G et al. (2021) |
Sensory | Sensory-evoked response: inhibition: visual stimulus | abnormal | In vivo local field potential (LFP) recordings | P42 | Karmon G et al. (2021) |
Sensory | Rooting reflex | no change | Developmental milestone measurements | P1-12 | Karmon G et al. (2021) |
Sensory | Pain or nociception | decreased | Hot plate test | Adult | Karmon G et al. (2021) |
Sensory | Olfaction | abnormal | Olfactory discrimination test | Adult | Karmon G et al. (2021) |
Social behavior | Social approach | decreased | Three-chamber social approach test | Adult | Karmon G et al. (2021) |
Physiological parameters | Intestinal microbiota composition | abnormal | Quantitative PCR (qRT-PCR) | P84 | Karmon G et al. (2021) |
Physiological parameters | Intestinal microbiota composition | abnormal | Quantitative PCR (qRT-PCR) | P84 | Karmon G et al. (2021) |
Developmental profile | Size/growth | no change | Body weight measurement | P10 | Karmon G et al. (2021) |
Developmental profile | Size/growth | no change | Body weight measurement | Adult | Karmon G et al. (2021) |
Developmental profile | Size/growth | no change | Body weight measurement | Adult | Karmon G et al. (2021) |
Developmental profile | Size/growth | decreased | Body weight measurement | P10 | Karmon G et al. (2021) |
Developmental profile | Mortality/lethality | increased | RNA Sequencing | P1 | Karmon G et al. (2021) |
Developmental profile | General characteristics | no change | General observations | P1-21 | Karmon G et al. (2021) |
Developmental profile | General characteristics | abnormal | General observations | P1-21 | Karmon G et al. (2021) |
Learning & memory | Object recognition memory: long-term recall | decreased | Novel object recognition test | Adult | Karmon G et al. (2021) |
Molecular profile | Targeted expression | decreased | RNA Sequencing | P98 | Karmon G et al. (2021) |
Molecular profile | Protein aggregation: neuronal | increased | Immunohistochemistry | P70 | Karmon G et al. (2021) |
Molecular profile | Protein aggregation: neuronal | increased | Immunohistochemistry | P70 | Karmon G et al. (2021) |
Molecular profile | Protein aggregation: neuronal | no change | Immunohistochemistry | P70 | Karmon G et al. (2021) |
Molecular profile | Differential gene expression | no change | RNA Sequencing | P98 | Karmon G et al. (2021) |
Molecular profile | Differential gene expression | abnormal | RNA Sequencing | P98 | Karmon G et al. (2021) |
M_ADNP_4_KO_HT_NAP
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Pups were administered nap subcutaneously (25ug/1ml saline/day). twenty-one-day old mice were then administered nap intranasally (0.5üg/5ul vehicle/day)
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6NJ
Es cell line: C57BL/6N
Model Source: Karmon et al., 2021
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Righting response | restored | Righting reflex test | P8-21 | Karmon G et al. (2021) |
Motor phenotype | Motor coordination and balance | sustained effect | Wire hang test | Adult | Karmon G et al. (2021) |
Motor phenotype | Gait | restored | Running stride analysis | P70 | Karmon G et al. (2021) |
Motor phenotype | Gait | ameliorated | Running stride analysis | P70 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Ultrasonic vocalization: isolation induced | restored | Spectographic analysis of vocalization recordings | P8 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Ultrasonic vocalization: isolation induced | no sustained effect | Spectographic analysis of vocalization recordings | P8 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | restored | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Ear twitch reflex or preyer's reflex | restored | Preyer's Reflex test | P7-15 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | restored | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | restored | Immunohistochemistry | P42 | Karmon G et al. (2021) |
Repetitive behavior | Self grooming | restored | Open field test | Adult | Karmon G et al. (2021) |
Sensory | Vision | sustained effect | Cliff avoidance test | P1-14 | Karmon G et al. (2021) |
Sensory | Startle response: acoustic stimulus | restored | Acoustic startle reflex test | P7-18 | Karmon G et al. (2021) |
Sensory | Sensory-evoked response: inhibition: visual stimulus | restored | In vivo local field potential (LFP) recordings | P42 | Karmon G et al. (2021) |
Sensory | Rooting reflex | side effect | Developmental milestone measurements | P1-12 | Karmon G et al. (2021) |
Sensory | Pain or nociception | sustained effect | Hot plate test | Adult | Karmon G et al. (2021) |
Sensory | Olfaction | restored | Olfactory discrimination test | Adult | Karmon G et al. (2021) |
Physiological parameters | Intestinal microbiota composition | restored | Quantitative PCR (qRT-PCR) | P84 | Karmon G et al. (2021) |
Developmental profile | Size/growth | sustained effect | Body weight measurement | P10 | Karmon G et al. (2021) |
Developmental profile | Eye development | restored | General observations | P1-21 | Karmon G et al. (2021) |
Learning & memory | Object recognition memory: long-term recall | restored | Novel object recognition test | Adult | Karmon G et al. (2021) |
Molecular profile | Targeted expression | no sustained effect | RNA Sequencing | P98 | Karmon G et al. (2021) |
Molecular profile | Protein aggregation: neuronal | restored | Immunohistochemistry | P70 | Karmon G et al. (2021) |
Molecular profile | Protein aggregation: neuronal | restored | Immunohistochemistry | P70 | Karmon G et al. (2021) |
Molecular profile | Differential gene expression | no sustained effect | RNA Sequencing | P98 | Karmon G et al. (2021) |
Molecular profile | Differential gene expression | restored | RNA Sequencing | P98 | Karmon G et al. (2021) |
Other ADNP Rescue Models(6 Models)
M_ADNP_1_KO_HT | 3 | Genetic | Pharmaceutical | NAP |
M_ADNP_1_KO_HT | 2 | Genetic | Pharmaceutical | SKIP |
M_ADNP_2_KO_HT | 2 | Genetic | Pharmaceutical | NAP |
M_ADNP_3_KO_HT_STRESS | 1 | Multifactorial | Pharmaceutical | PACAP |
M_ADNP_3_KO_HT | 1 | Genetic | Pharmaceutical | NAP |
M_ADNP_4_KO_HT | 1 | Genetic | Pharmaceutical | NAP |
CNVs associated with ADNP(1 Models)
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20q13.13 | 14 | Deletion-Duplication | 20 / 38 |