Genetic Animal Models / ARID1B

ARID1B AT-rich interaction domain 1B

Model Species
Mus musculus
Gene Aliases
8030481M12, 9330189K18Rik, AI836955, Ardi1b, B230217J03Rik, mKIAA1235
Reports
2
Associated Human Genes
ARID1B
Models / Rescue Models
8 / 2
Rescue Model
-
Model Summary

Arid1b heterozygous mice showed social behavior impairment, altered vocalization, anxiety-like behavior, neuroanatomical abnormalities, and growth impairment. In the brain, Arid1b haploinsufficiency resulted in changes in the expression of SWI/SNF-regulated genes implicated in neuropsychiatric disorders, including deficiency in insulin-like growth factor 1. Supplementation with growth hormone restored muscle weakness and growth retardation in Arid1b heterozygous mice.

Reports related to ARID1B (2 Reports)
# Type Title Author, Year
1 Primary Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. Celen C , et al. (2017)
2 Additional Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice. Shibutani M , et al. (2017)
Show all Construct Details Show all Phenotypic Profiles

M_ARID1B_1_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Cas9 germline gene-editing was used to flox exon5 of Arid1b and generate whole-body Arid1b knockout mice with a deleted exon 5.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Satiety response No change Food intake measurements 1.9 weeks Celen C , et al. (2017)
Physiological parameters Renal function No change Urine/blood electrolyte analysis 3.4 months Celen C , et al. (2017)
Physiological parameters Hormone levels No change ELISA 2 weeks, 0.9-1.4 months Celen C , et al. (2017)
Physiological parameters Hormone levels No change ELISA 1.1-1.5 months Celen C , et al. (2017)
Physiological parameters Hormone levels Decreased ELISA 0.9-1.4 months Celen C , et al. (2017)
Physiological parameters Homeostasis No change Cell counting 3.4 months Celen C , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype Grip strength Decreased Grip strength test Not reported Celen C , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 8 weeks Celen C , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Light-dark exploration test: Light-dark exploration test 8 weeks Celen C , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Elevated plus maze test 8 weeks Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number in the brain Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Immunohistochemistry 1.7 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Histology: Histology Not reported Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Decreased Immunohistochemistry 1.7 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cell proliferation: neural precursors Decreased Immunohistochemistry 1.7 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Gross necroscopy P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain development Decreased Gross necroscopy Not reported Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments Adult Celen C , et al. (2017)
Repetitive behavior Repetitive digging Decreased Marble-burying test Not reported Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory Pain or nociception No change Foot shock test 8 weeks Celen C , et al. (2017)
Social behavior Social interaction: with juveniles Decreased Reciprocal social interaction test Adult Celen C , et al. (2017)
Communications Ultrasonic vocalization: Isolation induced Abnormal Monitoring ultrasonic vocalizations P4 Celen C , et al. (2017)
Communications Audible vocalization Decreased General observations Not reported Celen C , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 0.9-1.2 months Celen C , et al. (2017)
Developmental profile Size/growth Decreased Body length measurement 0.9-1.2 months Celen C , et al. (2017)
Developmental profile Renal morphology Decreased Gross necroscopy P0-10 Celen C , et al. (2017)
Developmental profile Mortality/lethality: neonatal Increased General observations Adult Celen C , et al. (2017)
Developmental profile General characteristics No change General observations P0-10 Celen C , et al. (2017)
Developmental profile Digestive system development No change Gross necroscopy P0-10 Celen C , et al. (2017)
Developmental profile Cardiovascular development and function Decreased Gross necroscopy P0-10 Celen C , et al. (2017)
Emotion Anxiety Increased Open field test 8 weeks Celen C , et al. (2017)
Emotion Anxiety Increased Light-dark exploration test: Light-dark exploration test 8 weeks Celen C , et al. (2017)
Emotion Anxiety Increased Elevated plus maze test 8 weeks Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory Spatial working memory No change Morris water maze test 2 weeks Celen C , et al. (2017)
Learning & memory Spatial reference memory No change Morris water maze test 2 weeks Celen C , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of cue No change Fear conditioning test 8 weeks Celen C , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of context No change Fear conditioning test 8 weeks Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Not reported Celen C , et al. (2017)
Molecular profile Protein-DNA complex assembly Increased Chromatin immunoprecipitation (ChIP) 2.6-2.7 months Celen C , et al. (2017)
Molecular profile Gene expression Abnormal RNA sequencing 2.6-2.7 months Celen C , et al. (2017)
Molecular profile Gene expression No change Quantitative PCR (qRT-PCR) 1.1-1.5 months Celen C , et al. (2017)
Molecular profile Gene expression No change Quantitative PCR (qRT-PCR) 1.1-1.5 months Celen C , et al. (2017)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 1.4 months Celen C , et al. (2017)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) 1.4 months Celen C , et al. (2017)
Molecular profile Enzyme activity No change Enzyme assay 3.4 months Celen C , et al. (2017)

M_ARID1B_1_KO_HT_rhIGF1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Arid1b heterozygous knockouts were treated with 0.5mg/kg recombinant human IGF1 (rhIGF1) daily from P11 to 2 months.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype - Not Reported - - Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior - Not Reported - - Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory - Not Reported - - Celen C , et al. (2017)
Social behavior - Not Reported - - Celen C , et al. (2017)
Communications - Not Reported - - Celen C , et al. (2017)
Developmental profile Size/growth Refractory Body weight measurement 1.7 months Celen C , et al. (2017)
Emotion Anxiety Refractory Elevated plus maze test 1.7 months Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory - Not Reported - - Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile - Not Reported - - Celen C , et al. (2017)

M_ARID1B_1_KO_HT_rmGH

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Arid1b heterozygous knockouts were subcutaneously injected with 30microgram recombinant mouse growth hormone (rmGH) daily between postnatal day 11 and 14 and 50micrgram rmGH daily between postnatal day 14 and 21, and 70micrgram rmGH daily between postnatal day 21 and 50.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype Grip strength Restored Grip strength test 2 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior - Not Reported - - Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory - Not Reported - - Celen C , et al. (2017)
Social behavior - Not Reported - - Celen C , et al. (2017)
Communications - Not Reported - - Celen C , et al. (2017)
Developmental profile Size/growth Ameliorated Body weight measurement 1.7 months Celen C , et al. (2017)
Developmental profile Size/growth Ameliorated Body length measurement 1.7 months Celen C , et al. (2017)
Emotion Anxiety Refractory Elevated plus maze test 1.7 months Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory - Not Reported - - Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile - Not Reported - - Celen C , et al. (2017)

M_ARID1B_2_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Cas9 germline gene-editing was used to flox exon5 of Arid1b and generate whole-body Arid1b knockout mice with a deleted exon 5.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype - Not Reported - - Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number in the brain Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior - Not Reported - - Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory - Not Reported - - Celen C , et al. (2017)
Social behavior - Not Reported - - Celen C , et al. (2017)
Communications - Not Reported - - Celen C , et al. (2017)
Developmental profile Mortality/lethality: neonatal Increased General observations P0-10 Celen C , et al. (2017)
Emotion - Not Reported - - Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory - Not Reported - - Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile Targeted expression Decreased Western blot P0 Celen C , et al. (2017)

M_ARID1B_3_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 (floxed allele generated by Cas9 mediated editing) of the Arid1b gene using Albumin-cre, in the liver

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Hormone levels No change ELISA 1.4-1.5 months Celen C , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype - Not Reported - - Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior - Not Reported - - Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory - Not Reported - - Celen C , et al. (2017)
Social behavior - Not Reported - - Celen C , et al. (2017)
Communications - Not Reported - - Celen C , et al. (2017)
Developmental profile Size/growth No change Body weight measurement 1.1-3.1 weeks Celen C , et al. (2017)
Emotion - Not Reported - - Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory - Not Reported - - Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile - Not Reported - - Celen C , et al. (2017)

M_ARID1B_4_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 (floxed allele generated by Cas9 mediated editing) of the Arid1b gene using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Hormone levels Decreased ELISA 1.4-1.5 months Celen C , et al. (2017)
Physiological parameters Hormone levels Decreased ELISA Not reported Celen C , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype - Not Reported - - Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior - Not Reported - - Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory - Not Reported - - Celen C , et al. (2017)
Social behavior - Not Reported - - Celen C , et al. (2017)
Communications - Not Reported - - Celen C , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 1.1-5 weeks Celen C , et al. (2017)
Emotion - Not Reported - - Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory - Not Reported - - Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile - Not Reported - - Celen C , et al. (2017)

M_ARID1B_5_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 (floxed allele generated by Cas9 mediated editing) of the Arid1b gene using Ckm-Cre, in skeletal muscle

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Celen C , et al. (2017)
Motor phenotype - Not Reported - - Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Celen C , et al. (2017)
Neurophysiology - Not Reported - - Celen C , et al. (2017)
Repetitive behavior - Not Reported - - Celen C , et al. (2017)
Seizure - Not Reported - - Celen C , et al. (2017)
Sensory - Not Reported - - Celen C , et al. (2017)
Social behavior - Not Reported - - Celen C , et al. (2017)
Communications - Not Reported - - Celen C , et al. (2017)
Developmental profile Size/growth No change Body weight measurement 1.1-3.1 weeks Celen C , et al. (2017)
Developmental profile General characteristics No change General observations Not reported Celen C , et al. (2017)
Emotion - Not Reported - - Celen C , et al. (2017)
Homeostasis - Not Reported - - Celen C , et al. (2017)
Immune response - Not Reported - - Celen C , et al. (2017)
Learning & memory - Not Reported - - Celen C , et al. (2017)
Maternal behavior - Not Reported - - Celen C , et al. (2017)
Molecular profile - Not Reported - - Celen C , et al. (2017)

M_ARID1B_6_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

CRISPR/Cas9 double-nicking method of gene editing was used to generate a deletion in exon 3.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Core body temperature No change Body temperature measurement 10-13 weeks Shibutani M , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - Shibutani M , et al. (2017)
Motor phenotype Motor coordination and balance Decreased Balance beam test 16-19 weeks Shibutani M , et al. (2017)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 12-15 weeks Shibutani M , et al. (2017)
Motor phenotype Grip strength Decreased Wire hang test 1013 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity Decreased Elevated plus maze test 11-14 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Light-dark exploration test: Light-dark exploration test 10-13 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity Decreased Open field test 11-13 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity No change Reciprocal social interaction test 12-14 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity Decreased Reciprocal social interaction test 39-42 weeks Shibutani M , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain development Abnormal General observations 8-12 weeks Shibutani M , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture No change Histology: Histology 8-9 weeks Shibutani M , et al. (2017)
Neurophysiology - Not Reported - - Shibutani M , et al. (2017)
Repetitive behavior Circling Decreased Open field test 11-13 weeks Shibutani M , et al. (2017)
Seizure - Not Reported - - Shibutani M , et al. (2017)
Sensory Startle response: acoustic stimulus Decreased Startle response test: Startle response test 13-16 weeks Shibutani M , et al. (2017)
Sensory Startle response: acoustic stimulus No change Startle response test: Startle response test 13-16 weeks Shibutani M , et al. (2017)
Sensory Sensorimotor gating No change Prepulse inhibition 13-16 weeks Shibutani M , et al. (2017)
Sensory Sensorimotor gating Decreased Prepulse inhibition 13-16 weeks Shibutani M , et al. (2017)
Sensory Pain or nociception No change Hot plate test 12-14 weeks Shibutani M , et al. (2017)
Sensory Foot shock sensitivity Decreased Fear conditioning test 33-36 weeks Shibutani M , et al. (2017)
Social behavior Social memory No change Three-chamber social approach test 13-15 weeks Shibutani M , et al. (2017)
Social behavior Social interaction No change Reciprocal social interaction test 12-14 weeks Shibutani M , et al. (2017)
Social behavior Social interaction Increased Reciprocal social interaction test 39-42 weeks Shibutani M , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test 13-15 weeks Shibutani M , et al. (2017)
Communications - Not Reported - - Shibutani M , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 10-13 weeks Shibutani M , et al. (2017)
Emotion Depression Decreased Forced swim test 13-16 weeks Shibutani M , et al. (2017)
Emotion Anxiety No change Light-dark exploration test: Light-dark exploration test 10-13 weeks Shibutani M , et al. (2017)
Emotion Anxiety No change Open field test 11-13 weeks Shibutani M , et al. (2017)
Emotion Anxiety Increased Elevated plus maze test 11-14 weeks Shibutani M , et al. (2017)
Homeostasis - Not Reported - - Shibutani M , et al. (2017)
Immune response - Not Reported - - Shibutani M , et al. (2017)
Learning & memory Spatial reference memory Increased Barnes maze test 16-23 weeks Shibutani M , et al. (2017)
Learning & memory Spatial learning No change Barnes maze test 16-23 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of cue: Long term recall Increased Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of cue No change Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of context: Long term recall No change Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of context No change Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cognitive flexibility Decreased Barnes maze test 16-23 weeks Shibutani M , et al. (2017)
Maternal behavior - Not Reported - - Shibutani M , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Not reported Shibutani M , et al. (2017)
Molecular profile Gene expression Decreased RNA sequencing Not reported Shibutani M , et al. (2017)
Molecular profile Gene expression Decreased RNA sequencing Not reported Shibutani M , et al. (2017)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) Not reported Shibutani M , et al. (2017)
Other ARID1B Rescue Models(2 Models)
M_ARID1B_1_KO_HT 1 Genetic Pharmaceutical recombinant human insulin like growth factor 1
M_ARID1B_1_KO_HT 1 Genetic Pharmaceutical recombinant mouse growth hormone
CNVs associated with ARID1B(1 Models)
6q25.3 15 Deletion-Duplication 25  /  45
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