Genetic Mouse Models / ARID1B

ARID1B AT-rich interaction domain 1B

Model Species
Mus musculus
Gene Aliases
8030481M12, 9330189K18Rik, AI836955, Ardi1b, B230217J03Rik, mKIAA1235
Reports
6
Associated Human Genes
ARID1B
Models / Rescue Models
18 / 4
Rescue Model
-
Model Summary

Arid1b heterozygous mice showed social behavior impairment, altered vocalization, anxiety-like behavior, neuroanatomical abnormalities, and growth impairment. In the brain, Arid1b haploinsufficiency resulted in changes in the expression of SWI/SNF-regulated genes implicated in neuropsychiatric disorders, including deficiency in insulin-like growth factor 1. Supplementation with growth hormone restored muscle weakness and growth retardation in Arid1b heterozygous mice.

External Links
Entrez GeneMouse Genome InformaticsAllen Brain Atlas
Reports related to ARID1B (6 Reports)
# Type Title Author, Year
1 Primary Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. Celen C , et al. (2017)
2 Additional Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice. Shibutani M , et al. (2017)
3 Additional Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior Jung EM et al. (2017)
4 Additional Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior Smith AL et al. (2020)
5 Additional Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development Ellegood J et al. (2021)
6 Additional Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming Kim H et al. (2022)
Show all Construct Details Show all Phenotypic Profiles

M_ARID1B_10_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The Arid1b-floxed allele was crossed with the PV-Cre (B6;129P2-Pvalbtm1(cre)Arbr/J; JAX 008069) allele. Exon 5 of Arid1b was floxed as in model M_ARID1B_7_KO_HT.

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL6
Genetic Background: NA

Es cell line: NA
Model Source: 29184203 (Jung et al, Nat Neurosci, 2017)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype Swimming ability No change Morris water maze test 2-4 months Smith AL et al. (2020)
Motor phenotype Motor learning No change Accelerating rotarod test 2-4 months Smith AL et al. (2020)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-4 months Smith AL et al. (2020)
Motor phenotype General locomotor activity No change Open field test 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Western blot 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Immunohistochemistry 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory No change Immunohistochemistry 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Measurement of tissue weight 2-4 months Smith AL et al. (2020)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 2-4 months Smith AL et al. (2020)
Social behavior Social memory Decreased Three-chamber social approach test 2-4 months Smith AL et al. (2020)
Social behavior Social approach Decreased Three-chamber social approach test 2-4 months Smith AL et al. (2020)
Developmental profile Size/growth No change Body weight measurement 2-4 months Smith AL et al. (2020)
Emotion Depression Increased Tail suspension test 2-4 months Smith AL et al. (2020)
Emotion Anxiety Increased Elevated plus maze test 2-4 months Smith AL et al. (2020)
Emotion Anxiety Increased Open field test 2-4 months Smith AL et al. (2020)
Learning & memory Swim distance No change Morris water maze test 2-4 months Smith AL et al. (2020)
Learning & memory Spatial working memory No change Morris water maze test 2-4 months Smith AL et al. (2020)
Learning & memory Spatial reference memory No change Morris water maze test 2-4 months Smith AL et al. (2020)
Learning & memory Object recognition memory No change Novel object recognition test 2-4 months Smith AL et al. (2020)
Molecular profile Targeted expression Decreased Immunohistochemistry 2-4 months Smith AL et al. (2020)

M_ARID1B_11_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The Arid1b-floxed allele was crossed with the SST-Cre (B6N.Cg-Ssttm2.1(cre)Zjh/J; JAX 018973) allele. Exon 5 of Arid1b was floxed as in model M_ARID1B_7_KO_HT.

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL6
Genetic Background: NA

Es cell line: NA
Model Source: 29184203 (Jung et al, Nat Neurosci, 2017)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype Swimming ability No change Morris water maze test 2-4 months Smith AL et al. (2020)
Motor phenotype Motor learning Decreased Accelerating rotarod test 2-4 months Smith AL et al. (2020)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-4 months Smith AL et al. (2020)
Motor phenotype General locomotor activity No change Open field test 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Western blot 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Immunohistochemistry 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory No change Immunohistochemistry 2-4 months Smith AL et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Measurement of tissue weight 2-4 months Smith AL et al. (2020)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 2-4 months Smith AL et al. (2020)
Social behavior Social memory No change Three-chamber social approach test 2-4 months Smith AL et al. (2020)
Social behavior Social approach No change Three-chamber social approach test 2-4 months Smith AL et al. (2020)
Developmental profile Size/growth No change Body weight measurement 2-4 months Smith AL et al. (2020)
Emotion Depression No change Tail suspension test 2-4 months Smith AL et al. (2020)
Emotion Anxiety No change Elevated plus maze test 2-4 months Smith AL et al. (2020)
Emotion Anxiety No change Open field test 2-4 months Smith AL et al. (2020)
Learning & memory Swim distance No change Morris water maze test 2-4 months Smith AL et al. (2020)
Learning & memory Spatial working memory Decreased Morris water maze test 2-4 months Smith AL et al. (2020)
Learning & memory Spatial reference memory Decreased Morris water maze test 2-4 months Smith AL et al. (2020)
Learning & memory Object recognition memory Decreased Novel object recognition test 2-4 months Smith AL et al. (2020)
Molecular profile Targeted expression Decreased Immunohistochemistry 2-4 months Smith AL et al. (2020)

M_ARID1B_12_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Targeting of Arid1b exon 5 employed Cas9 nuclease (D10A) and single-guide RNAs with spacer sequences for targeting exon 5, resulting in deletion of Chr17.

Allele Type: Knockout
Strain of Origin: C57BL/6NCrl
Genetic Background: C57BL/6N

Es cell line: NA
Model Source: Toronto Centre for Phenogenomics
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Developmental profile Mortality/lethality: embryonic Increased General observations E1-E10 Ellegood J et al. (2021)
Molecular profile Targeted expression Decreased Western blot P0 Kim H et al. (2022)

M_ARID1B_13_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Targeting of Arid1b exon 5 employed Cas9 nuclease (D10A) and single-guide RNAs with spacer sequences for targeting exon 5, resulting in deletion of Chr17.

Allele Type: Knockout
Strain of Origin: C57BL/6NCrl
Genetic Background: C57BL/6N

Es cell line: NA
Model Source: Toronto Centre for Phenogenomics
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-3 months Kim H et al. (2022)
Motor phenotype Spinal reflex Decreased General observations P2-12 Ellegood J et al. (2021)
Motor phenotype Righting response No change Righting reflex test P2-12 Ellegood J et al. (2021)
Motor phenotype Negative Geotaxis Decreased Negative geotaxis test P2-12 Ellegood J et al. (2021)
Motor phenotype Motor coordination and balance Decreased General observations P2-12 Ellegood J et al. (2021)
Motor phenotype Limb Posture No change General observations Adult Ellegood J et al. (2021)
Motor phenotype Hypoactivity Increased Open field test Adult Ellegood J et al. (2021)
Motor phenotype Grip strength Decreased Grip strength test 17 weeks Ellegood J et al. (2021)
Motor phenotype General locomotor activity: Ambulatory activity Decreased Open field test Adult, 11 weeks Ellegood J et al. (2021)
Motor phenotype General locomotor activity Decreased Distance traveled in a grid P2-12 Ellegood J et al. (2021)
Motor phenotype Gait No change Footprint analysis Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology: synaptic cleft length No change Electron microscopy 3 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: Inhibitory No change Electron microscopy 2 months Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Decreased Electron microscopy 3 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Size of cerebral ventricles: third ventricle No change Histology 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Size of cerebral ventricles: lateral ventricle Increased Histology 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size No change Electron microscopy 3 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Inhibitory neurons No change In situ hybridization (ISH) P7, P14, P56 Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Immunohistochemistry 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Histology 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Increased Sholl analysis 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness No change Histology 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination No change Immunohistochemistry 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Histology 6 weeks Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Size of cerebral ventricles: Lateral ventricle Increased Histology P0-P21 Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Olfactory bulb morphology Decreased Magnetic resonance imaging (MRI) Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Magnetic resonance imaging (MRI) Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: Striatum: Caudoputamen Decreased Magnetic resonance imaging (MRI) Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of telencephalon Decreased Magnetic resonance imaging (MRI) Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Magnetic resonance imaging (MRI) Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hydrocephaly Increased Histology P0-P21 Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Increased Magnetic resonance imaging (MRI) P2-2 months Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology Decreased Magnetic resonance imaging (MRI) P2-2 months Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Macroscopic analysis P2-12, adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Magnetic resonance imaging (MRI) P2-2 months, Adult Ellegood J et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain anatomy Decreased Magnetic resonance imaging (MRI) Adult Ellegood J et al. (2021)
Neurophysiology Synaptic transmission: inhibitory No change Whole-cell patch clamp 2 months Kim H et al. (2022)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp 2 months Kim H et al. (2022)
Neurophysiology Miniature post synaptic current frequency: inhibitory No change Whole-cell patch clamp 3 weeks Kim H et al. (2022)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp 3 weeks Kim H et al. (2022)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 3 weeks Kim H et al. (2022)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp 3 weeks Kim H et al. (2022)
Neurophysiology Membrane potential No change Whole-cell patch clamp 2 months Kim H et al. (2022)
Neurophysiology Intrinsic membrane properties No change Whole-cell patch clamp 2 months Kim H et al. (2022)
Neurophysiology Action potential property: threshold No change Whole-cell patch clamp 2 months Kim H et al. (2022)
Neurophysiology Action potential property: firing rate No change Whole-cell patch clamp 2 months Kim H et al. (2022)
Repetitive behavior Self grooming Increased Home cage behavior 2-3 months Kim H et al. (2022)
Repetitive behavior Vertical jumping or back flipping Decreased Open field test Adult Ellegood J et al. (2021)
Repetitive behavior Self grooming No change Grooming behavior assessments 15 weeks Ellegood J et al. (2021)
Repetitive behavior Circling No change Novel cage test Adult Ellegood J et al. (2021)
Seizure Seizures Increased Observation of chemically induced seizures 18-19 weeks Ellegood J et al. (2021)
Sensory Core body temperature No change Body temperature measurement PND2-14 Ellegood J et al. (2021)
Social behavior Social memory No change Three-chamber social approach test 2-3 months Kim H et al. (2022)
Social behavior Social interaction Decreased Reciprocal social interaction test 2-3 months Kim H et al. (2022)
Social behavior Social approach No change Three-chamber social approach test 2-3 months Kim H et al. (2022)
Social behavior Social interaction: opposite sex Decreased Reciprocal social interaction test 16 weeks Ellegood J et al. (2021)
Social behavior Social approach No change Three-chamber social approach test 15 weeks Ellegood J et al. (2021)
Social behavior Allogrooming No change Grooming behavior assessments 15 weeks Ellegood J et al. (2021)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P3-11 Kim H et al. (2022)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations PND2-14 Ellegood J et al. (2021)
Communications Ultrasonic vocalization: Interaction induced: opposite sex stimulus Decreased Monitoring ultrasonic vocalizations Adult Ellegood J et al. (2021)
Developmental profile Size/growth Decreased Body weight measurement P3-P49 Kim H et al. (2022)
Developmental profile Mortality/lethality No change General observations P0 Kim H et al. (2022)
Developmental profile Size/growth Decreased Body weight measurement P2-12, Adult Ellegood J et al. (2021)
Developmental profile Size/growth Decreased Body length measurement P2-12 Ellegood J et al. (2021)
Developmental profile Developmental trajectory Decreased General observations P2-P14 Ellegood J et al. (2021)
Emotion Exploratory activity Decreased Novel object recognition test 2-3 months Kim H et al. (2022)
Emotion Anxiety No change Open field test 2-3 months Kim H et al. (2022)
Emotion Anxiety No change Elevated plus maze test 2-3 months Kim H et al. (2022)
Emotion Anxiety No change Light-dark exploration test 2-3 months Kim H et al. (2022)
Emotion Exploratory activity: Habituation No change Open field test Adult Ellegood J et al. (2021)
Emotion Anxiety Increased Elevated plus maze test 10 weeks Ellegood J et al. (2021)
Emotion Anxiety No change Light-dark exploration test 10 weeks Ellegood J et al. (2021)
Learning & memory Object recognition memory No change Novel object recognition test 2-3 months Kim H et al. (2022)
Learning & memory Visual discrimination learning Increased Operant self-learning paradigm 9-17 weeks Ellegood J et al. (2021)
Learning & memory Object recognition memory Decreased Novel object recognition test 13 weeks Ellegood J et al. (2021)
Learning & memory Cued or contextual fear conditioning: Memory of cue No change Fear conditioning test 18 weeks Ellegood J et al. (2021)
Learning & memory Cued or contextual fear conditioning: Memory of context No change Fear conditioning test 18 weeks Ellegood J et al. (2021)
Learning & memory Cognitive flexibility No change Operant self-learning paradigm 12 weeks Ellegood J et al. (2021)
Molecular profile Targeted expression Decreased Western blot P0 Kim H et al. (2022)
Molecular profile Protein phosphorylation Decreased Western blot 3-6 months Kim H et al. (2022)
Molecular profile Protein expression level evidence Decreased Western blot 3-6 months Kim H et al. (2022)
Molecular profile Protein expression level evidence Increased Western blot 3-6 months Kim H et al. (2022)
Molecular profile Differential gene expression: ASD risk genes Abnormal RNA sequencing P3-P10 Kim H et al. (2022)
Molecular profile Differential gene expression Abnormal RNA sequencing P3-P10 Kim H et al. (2022)
Molecular profile Targeted expression Decreased Quantitative PCR (qRT-PCR) Adult Ellegood J et al. (2021)
Molecular profile Targeted expression Decreased Western blot Adult Ellegood J et al. (2021)
Molecular profile Differential gene expression Abnormal RNA sequencing 5 months Ellegood J et al. (2021)

M_ARID1B_13_KO_HT_FLUOXETINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Treated with Fluoxetine at P3-P21

Allele Type: Knockout
Strain of Origin: C57BL/6NCrl
Genetic Background: C57BL/6N

Es cell line: -
Model Source: Toronto Centre for Phenogenomics
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: ambulatory activity Side effect Open field test 2-3 months Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology: synaptic cleft length No adverse effect Electron microscopy 3-6 months Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Restored Electron microscopy 3 months Kim H et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size No adverse effect Electron microscopy 3-6 months Kim H et al. (2022)
Neurophysiology Presynaptic function: paired-pulse facilitation No adverse effect Whole-cell patch clamp 3 months Kim H et al. (2022)
Neurophysiology Neurotransmitter release: serotonin No change Liquid chromatography-mass spectrometry (LC-MS) 3-6 months Kim H et al. (2022)
Neurophysiology Miniature post synaptic current frequency: excitatory Restored Whole-cell patch clamp 3 months Kim H et al. (2022)
Neurophysiology Miniature post synaptic current amplitude: excitatory No adverse effect Whole-cell patch clamp 3 months Kim H et al. (2022)
Repetitive behavior Self grooming Restored Home cage behavior 2-3 months Kim H et al. (2022)
Social behavior Social interaction Ameliorated Reciprocal social interaction test 2-3 months Kim H et al. (2022)
Developmental profile Size/growth Refractory Body weight measurement 2-3 months Kim H et al. (2022)
Emotion Depression No change Forced swim test 3-6 months Kim H et al. (2022)
Emotion Anxiety No adverse effect Open field test 2-3 months Kim H et al. (2022)
Molecular profile Protein phosphorylation Restored Western blot 3-6 months Kim H et al. (2022)
Molecular profile Protein expression level evidence Restored Western blot 3-6 months Kim H et al. (2022)
Molecular profile Differential gene expression Ameliorated RNA sequencing 4 months Kim H et al. (2022)

M_ARID1B_14_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Mice harboring a cassette containing the Ardi1b gene flanked by loxP and lacZ sites flanked by FRT sites were obtained from EUCOMM. This Arid1b^tm1a(EUCOMM)Hmgu mouse line was crossed with Protamine-Flp mice to remove the cassette and produce Arid1bfl/+ mice. Sert-Cre; Arid1b^fl/+ mice were generated by crossing Sert-Cre female mice from Jackson Laboratory (B6.129(Cg)-Slc6a4^tm1(cre)Xz/J) with Arid1b^fl/fl male mice.

Allele Type: Conditional knockout
Strain of Origin: C57BL/6N; 129S1/Sv-Oca2+ Tyr+ Kitl+
Genetic Background: C57BL/6J

Es cell line: JM8.N4; W9.5/W95
Model Source: Helmholtz Zentrum Muenchen GmbH; Xiaoxi Zhuang
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Repetitive behavior Self grooming No change Home cage behavior 6 weeks Kim H et al. (2022)
Social behavior Social interaction No change Reciprocal social interaction test 6 weeks Kim H et al. (2022)

M_ARID1B_1_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Cas9 germline gene-editing was used to flox exon5 of Arid1b and generate whole-body Arid1b knockout mice with a deleted exon 5.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype Grip strength Decreased Grip strength test Not reported Celen C , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 8 weeks Celen C , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Light-dark exploration test 8 weeks Celen C , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Elevated plus maze test 8 weeks Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Immunohistochemistry 1.7 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Histology Not reported Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Decreased Immunohistochemistry 1.7 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cell proliferation: neural precursors Decreased Immunohistochemistry 1.7 months Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Gross necroscopy P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain development Decreased Gross necroscopy Not reported Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments Adult Celen C , et al. (2017)
Repetitive behavior Repetitive digging Decreased Marble-burying test Not reported Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory Pain or nociception No change Foot shock test 8 weeks Celen C , et al. (2017)
Social behavior Social interaction: with juveniles Decreased Reciprocal social interaction test Adult Celen C , et al. (2017)
Physiological parameters Satiety response No change Food intake measurements 1.9 weeks Celen C , et al. (2017)
Physiological parameters Renal function No change Urine/blood electrolyte analysis 3.4 months Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters Hormone levels No change Elisa 2 weeks, 0.9-1.4 months Celen C , et al. (2017)
Physiological parameters Hormone levels No change Elisa 1.1-1.5 months Celen C , et al. (2017)
Physiological parameters Hormone levels Decreased Elisa 0.9-1.4 months Celen C , et al. (2017)
Physiological parameters Homeostasis No change Cell counting 3.4 months Celen C , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Abnormal Monitoring ultrasonic vocalizations P4 Celen C , et al. (2017)
Communications Audible vocalization Decreased General observations Not reported Celen C , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 0.9-1.2 months Celen C , et al. (2017)
Developmental profile Size/growth Decreased Body length measurement 0.9-1.2 months Celen C , et al. (2017)
Developmental profile Renal morphology Decreased Gross necroscopy P0-10 Celen C , et al. (2017)
Developmental profile Mortality/lethality: neonatal Increased General observations Adult Celen C , et al. (2017)
Developmental profile General characteristics No change General observations P0-10 Celen C , et al. (2017)
Developmental profile Digestive system development No change Gross necroscopy P0-10 Celen C , et al. (2017)
Developmental profile Cardiovascular development and function Decreased Gross necroscopy P0-10 Celen C , et al. (2017)
Emotion Anxiety Increased Open field test 8 weeks Celen C , et al. (2017)
Emotion Anxiety Increased Light-dark exploration test 8 weeks Celen C , et al. (2017)
Emotion Anxiety Increased Elevated plus maze test 8 weeks Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory Spatial working memory No change Morris water maze test 2 weeks Celen C , et al. (2017)
Learning & memory Spatial reference memory No change Morris water maze test 2 weeks Celen C , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 8 weeks Celen C , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 8 weeks Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Not reported Celen C , et al. (2017)
Molecular profile Protein-dna complex assembly Increased Chromatin immunoprecipitation (chip) 2.6-2.7 months Celen C , et al. (2017)
Molecular profile Gene expression Abnormal Rna sequencing 2.6-2.7 months Celen C , et al. (2017)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 1.1-1.5 months Celen C , et al. (2017)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 1.1-1.5 months Celen C , et al. (2017)
Molecular profile Gene expression Increased Quantitative pcr (qrt-pcr) 1.4 months Celen C , et al. (2017)
Molecular profile Gene expression Decreased Quantitative pcr (qrt-pcr) 1.4 months Celen C , et al. (2017)
Molecular profile Enzyme activity No change Enzyme assay 3.4 months Celen C , et al. (2017)

M_ARID1B_1_KO_HT_RHIGF1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Arid1b heterozygous knockouts were treated with 0.5mg/kg recombinant human IGF1 (rhIGF1) daily from P11 to 2 months.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype NA Not reported NA NA Celen C , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior NA Not reported NA NA Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory NA Not reported NA NA Celen C , et al. (2017)
Social behavior NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Communications NA Not reported NA NA Celen C , et al. (2017)
Developmental profile Size/growth Refractory Body weight measurement 1.7 months Celen C , et al. (2017)
Emotion Anxiety Refractory Elevated plus maze test 1.7 months Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory NA Not reported NA NA Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile NA Not reported NA NA Celen C , et al. (2017)

M_ARID1B_1_KO_HT_RMGH

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Arid1b heterozygous knockouts were subcutaneously injected with 30microgram recombinant mouse growth hormone (rmGH) daily between postnatal day 11 and 14 and 50micrgram rmGH daily between postnatal day 14 and 21, and 70micrgram rmGH daily between postnatal day 21 and 50.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype Grip strength Restored Grip strength test 2 months Celen C , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior NA Not reported NA NA Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory NA Not reported NA NA Celen C , et al. (2017)
Social behavior NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Communications NA Not reported NA NA Celen C , et al. (2017)
Developmental profile Size/growth Ameliorated Body weight measurement 1.7 months Celen C , et al. (2017)
Developmental profile Size/growth Ameliorated Body length measurement 1.7 months Celen C , et al. (2017)
Emotion Anxiety Refractory Elevated plus maze test 1.7 months Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory NA Not reported NA NA Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile NA Not reported NA NA Celen C , et al. (2017)

M_ARID1B_2_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Cas9 germline gene-editing was used to flox exon5 of Arid1b and generate whole-body Arid1b knockout mice with a deleted exon 5.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype NA Not reported NA NA Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunohistochemistry P0-10 Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior NA Not reported NA NA Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory NA Not reported NA NA Celen C , et al. (2017)
Social behavior NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Communications NA Not reported NA NA Celen C , et al. (2017)
Developmental profile Mortality/lethality: neonatal Increased General observations P0-10 Celen C , et al. (2017)
Emotion NA Not reported NA NA Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory NA Not reported NA NA Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile Targeted expression Decreased Western blot P0 Celen C , et al. (2017)

M_ARID1B_3_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 (floxed allele generated by Cas9 mediated editing) of the Arid1b gene using Albumin-cre, in the liver

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype NA Not reported NA NA Celen C , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior NA Not reported NA NA Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory NA Not reported NA NA Celen C , et al. (2017)
Social behavior NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters Hormone levels No change Elisa 1.4-1.5 months Celen C , et al. (2017)
Communications NA Not reported NA NA Celen C , et al. (2017)
Developmental profile Size/growth No change Body weight measurement 1.1-3.1 weeks Celen C , et al. (2017)
Emotion NA Not reported NA NA Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory NA Not reported NA NA Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile NA Not reported NA NA Celen C , et al. (2017)

M_ARID1B_4_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 (floxed allele generated by Cas9 mediated editing) of the Arid1b gene using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype NA Not reported NA NA Celen C , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior NA Not reported NA NA Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory NA Not reported NA NA Celen C , et al. (2017)
Social behavior NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters Hormone levels Decreased Elisa 1.4-1.5 months Celen C , et al. (2017)
Physiological parameters Hormone levels Decreased Elisa Not reported Celen C , et al. (2017)
Communications NA Not reported NA NA Celen C , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 1.1-5 weeks Celen C , et al. (2017)
Emotion NA Not reported NA NA Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory NA Not reported NA NA Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile NA Not reported NA NA Celen C , et al. (2017)

M_ARID1B_5_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 (floxed allele generated by Cas9 mediated editing) of the Arid1b gene using Ckm-Cre, in skeletal muscle

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Celen C , et al. (2017)
Motor phenotype NA Not reported NA NA Celen C , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Celen C , et al. (2017)
Neurophysiology NA Not reported NA NA Celen C , et al. (2017)
Repetitive behavior NA Not reported NA NA Celen C , et al. (2017)
Seizure NA Not reported NA NA Celen C , et al. (2017)
Sensory NA Not reported NA NA Celen C , et al. (2017)
Social behavior NA Not reported NA NA Celen C , et al. (2017)
Physiological parameters NA Not reported NA NA Celen C , et al. (2017)
Communications NA Not reported NA NA Celen C , et al. (2017)
Developmental profile Size/growth No change Body weight measurement 1.1-3.1 weeks Celen C , et al. (2017)
Developmental profile General characteristics No change General observations Not reported Celen C , et al. (2017)
Emotion NA Not reported NA NA Celen C , et al. (2017)
Immune response NA Not reported NA NA Celen C , et al. (2017)
Learning & memory NA Not reported NA NA Celen C , et al. (2017)
Maternal behavior NA Not reported NA NA Celen C , et al. (2017)
Molecular profile NA Not reported NA NA Celen C , et al. (2017)

M_ARID1B_6_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

CRISPR/Cas9 double-nicking method of gene editing was used to generate a deletion in exon 3.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Shibutani M , et al. (2017)
Motor phenotype Motor coordination and balance Decreased Balance beam test 16-19 weeks Shibutani M , et al. (2017)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 12-15 weeks Shibutani M , et al. (2017)
Motor phenotype Grip strength Decreased Wire hang test 1013 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Decreased Elevated plus maze test 11-14 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Light-dark exploration test 10-13 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test 11-13 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity No change Reciprocal social interaction test 12-14 weeks Shibutani M , et al. (2017)
Motor phenotype General locomotor activity Decreased Reciprocal social interaction test 39-42 weeks Shibutani M , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain development Abnormal General observations 8-12 weeks Shibutani M , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture No change Histology 8-9 weeks Shibutani M , et al. (2017)
Neurophysiology NA Not reported NA NA Shibutani M , et al. (2017)
Repetitive behavior Circling Decreased Open field test 11-13 weeks Shibutani M , et al. (2017)
Seizure NA Not reported NA NA Shibutani M , et al. (2017)
Sensory Startle response: acoustic stimulus Decreased Startle response test 13-16 weeks Shibutani M , et al. (2017)
Sensory Startle response: acoustic stimulus No change Startle response test 13-16 weeks Shibutani M , et al. (2017)
Sensory Sensorimotor gating No change Prepulse inhibition 13-16 weeks Shibutani M , et al. (2017)
Sensory Sensorimotor gating Decreased Prepulse inhibition 13-16 weeks Shibutani M , et al. (2017)
Sensory Pain or nociception No change Hot plate test 12-14 weeks Shibutani M , et al. (2017)
Sensory Foot shock sensitivity Decreased Fear conditioning test 33-36 weeks Shibutani M , et al. (2017)
Social behavior Social memory No change Three-chamber social approach test 13-15 weeks Shibutani M , et al. (2017)
Social behavior Social interaction No change Reciprocal social interaction test 12-14 weeks Shibutani M , et al. (2017)
Social behavior Social interaction Increased Reciprocal social interaction test 39-42 weeks Shibutani M , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test 13-15 weeks Shibutani M , et al. (2017)
Physiological parameters NA Not reported NA NA Shibutani M , et al. (2017)
Physiological parameters Core body temperature No change Body temperature measurement 10-13 weeks Shibutani M , et al. (2017)
Communications NA Not reported NA NA Shibutani M , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 10-13 weeks Shibutani M , et al. (2017)
Emotion Depression Decreased Forced swim test 13-16 weeks Shibutani M , et al. (2017)
Emotion Anxiety No change Light-dark exploration test 10-13 weeks Shibutani M , et al. (2017)
Emotion Anxiety No change Open field test 11-13 weeks Shibutani M , et al. (2017)
Emotion Anxiety Increased Elevated plus maze test 11-14 weeks Shibutani M , et al. (2017)
Immune response NA Not reported NA NA Shibutani M , et al. (2017)
Learning & memory Spatial reference memory Increased Barnes maze test 16-23 weeks Shibutani M , et al. (2017)
Learning & memory Spatial learning No change Barnes maze test 16-23 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of cue: long term recall Increased Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of context: long term recall No change Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 33-40 weeks Shibutani M , et al. (2017)
Learning & memory Cognitive flexibility Decreased Barnes maze test 16-23 weeks Shibutani M , et al. (2017)
Maternal behavior NA Not reported NA NA Shibutani M , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Not reported Shibutani M , et al. (2017)
Molecular profile Gene expression Decreased Rna sequencing Not reported Shibutani M , et al. (2017)
Molecular profile Gene expression Decreased Rna sequencing Not reported Shibutani M , et al. (2017)
Molecular profile Gene expression Decreased Quantitative pcr (qrt-pcr) Not reported Shibutani M , et al. (2017)

M_ARID1B_7_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Exon 5 of the Arid1b gene was flanked by loxp sites to create a deletion allele. To generate the global Arid1b KO allele, the knockout first allele was crossed with a CMV-Cre mouse strain (Jackson Llaboratory, #006054), and the resulting Arid1b KO allele in which the neo cassette, one FRT, one loxP, and exon 5 were removed was selected by genomic PCR and sequencing. Lack of Arid1b protein in the null mice was confirmed.

Allele Type: Knockout
Strain of Origin: C57BL6
Genetic Background: NA

Es cell line: NA
Model Source: NA
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype Swimming ability No change Morris water maze test 3-4 months Jung EM et al. (2017)
Motor phenotype Motor learning Decreased Accelerating rotarod test 3-4 months Jung EM et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test 3-4 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic neuroreceptors Decreased Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology: synaptic cleft length Increased Electron microscopy 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Immunohistochemistry 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory Decreased Western blot 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory No change Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory No change Immunohistochemistry 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory No change Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size: inhibitory synapses Decreased Electron microscopy 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: gaba-r: gabaa No change Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry 1month; 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: inhibitory neurons Decreased Immunohistochemistry 1month; 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: excitatory neurons No change Immunohistochemistry 1 month, 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Immunohistochemistry 1 month, 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial number No change Immunohistochemistry 1month; 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Abnormal Immunohistochemistry 1 month, 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cell proliferation: neural precursors Decreased Immunohistochemistry E12.5 Jung EM et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp 3-4 months Jung EM et al. (2017)
Neurophysiology Miniature post synaptic current frequency: excitatory No change Whole-cell patch clamp 3-4 months Jung EM et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 3-4 months Jung EM et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp 3-4 months Jung EM et al. (2017)
Neurophysiology Apoptosis: brain cells Increased Immunohistochemistry E12.5 Jung EM et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 3-4 months Jung EM et al. (2017)
Social behavior Social memory Decreased Three-chamber social approach test 3-4 months Jung EM et al. (2017)
Social behavior Social interaction Decreased Reciprocal social interaction test 3-4 months Jung EM et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 3-4 months Jung EM et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement P14, 21, 28, 56 and 63 Jung EM et al. (2017)
Emotion Depression Increased Forced swim test 3-4 months Jung EM et al. (2017)
Emotion Anxiety Increased Elevated plus maze test 3-4 months Jung EM et al. (2017)
Emotion Anxiety Increased Open field test 3-4 months Jung EM et al. (2017)
Learning & memory Swim distance No change Morris water maze test 3-4 months Jung EM et al. (2017)
Learning & memory Spatial working memory Decreased Morris water maze test 3-4 months Jung EM et al. (2017)
Learning & memory Spatial reference memory Decreased Morris water maze test 3-4 months Jung EM et al. (2017)
Learning & memory Reward reinforced choice behavior Decreased T-maze test 3-4 months Jung EM et al. (2017)
Learning & memory Object recognition memory Decreased Novel object recognition test 3-4 months Jung EM et al. (2017)
Molecular profile Targeted expression Decreased Quantitative pcr (qrt-pcr) E14.5 Jung EM et al. (2017)
Molecular profile Targeted expression Decreased Western blot E14.5 Jung EM et al. (2017)
Molecular profile Signaling: wnt pathway Decreased Western blot E15.5 Jung EM et al. (2017)
Molecular profile Regulation of gene expression Decreased Chromatin immunoprecipitation sequencing (chip-seq) 3 months Jung EM et al. (2017)
Molecular profile Protein-dna complex assembly Decreased Chromatin immunoprecipitation sequencing (chip-seq) 3 months Jung EM et al. (2017)
Molecular profile Protein localization: nucleus No change Western blot 3 months Jung EM et al. (2017)
Molecular profile Protein expression level evidence No change Western blot 3 months Jung EM et al. (2017)
Molecular profile Protein expression level evidence Decreased Western blot 3 months Jung EM et al. (2017)
Molecular profile Protein binding Decreased Co-immunoprecipitation 3 months Jung EM et al. (2017)
Molecular profile Protein binding Decreased Proximity ligation assay 3 months Jung EM et al. (2017)
Molecular profile Gene expression: wnt pathway Decreased Quantitative pcr (qrt-pcr) E15.5 Jung EM et al. (2017)
Molecular profile Enzyme activity No change Western blot 3 months Jung EM et al. (2017)
Molecular profile Chromatin modification: histone modification: open chromatin Decreased Western blot 3 months Jung EM et al. (2017)
Molecular profile Chromatin modification: histone acetylation Decreased Chromatin immunoprecipitation sequencing (chip-seq) 3 months Jung EM et al. (2017)
Molecular profile Chromatin modification No change Quantitative pcr (qrt-pcr) 3 months Jung EM et al. (2017)

M_ARID1B_7_KO_HT_CLONAZEPAM

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Arid1b heterozygous mutant mice were intraperitoneally injected with clonazepam, a positive allosteric modulator of GABAA receptor

Allele Type: Knockout
Strain of Origin: C57BL6
Genetic Background: NA

Es cell line: NA
Model Source: NA
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: ambulatory activity Restored Open field test 3-4 months Jung EM et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory Restored Whole-cell patch clamp 3-4 months Jung EM et al. (2017)
Social behavior Social memory Restored Three-chamber social approach test 3-4 months Jung EM et al. (2017)
Emotion Anxiety Restored Open field test 3-4 months Jung EM et al. (2017)
Learning & memory Object recognition memory Restored Novel object recognition test 3-4 months Jung EM et al. (2017)

M_ARID1B_8_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Mice with exon 5 of Arid1b floxed were crossed with Dlx5/6-Cre-IRES-EGFP

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL6
Genetic Background: NA

Es cell line: NA
Model Source: 29184203 (Jung et al, Nat Neurosci, 2017)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test 3-4 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry E12.5, e14.5, e16.5 and e18.5 Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: inhibitory neurons Decreased Immunohistochemistry 1month; 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal morphology Decreased Immunohistochemistry 3 months Jung EM et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal migration No change Immunohistochemistry E14.5, e18.5 Jung EM et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 3-4 months Jung EM et al. (2017)
Social behavior Social memory Decreased Three-chamber social approach test 3-4 months Jung EM et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 3-4 months Jung EM et al. (2017)
Emotion Anxiety Increased Open field test 3-4 months Jung EM et al. (2017)
Learning & memory Object recognition memory Decreased Novel object recognition test 3-4 months Jung EM et al. (2017)

M_ARID1B_9_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Mice with exon 5 of Arid1b floxed were crossed with Nkx2.1-Cre mouse line

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL6
Genetic Background: NA

Es cell line: NA
Model Source: 29184203 (Jung et al, Nat Neurosci, 2017)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: inhibitory neurons Decreased Immunohistochemistry 1month; 3 months Jung EM et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 3-4 months Jung EM et al. (2017)
Other ARID1B Rescue Models(4 Models)
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M_ARID1B_1_KO_HT 1 Genetic Pharmaceutical recombinant human insulin like growth factor 1
M_ARID1B_1_KO_HT 1 Genetic Pharmaceutical recombinant mouse growth hormone
M_ARID1B_7_KO_HT 1 Genetic Pharmaceutical Clonazepam
M_ARID1B_13_KO_HT 1 Genetic Pharmaceutical Fluoxetine
CNVs associated with ARID1B(1 Models)
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6q25.3 21 Deletion-Duplication 32  /  51
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