Genetic Animal Models / CACNA1C

CACNA1C calcium voltage-gated channel subunit alpha1 C

Model Species
Rattus norvegicus
Gene Aliases
RATIVS302
Reports
2
Associated Human Genes
CACNA1C
Models / Rescue Models
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Rescue Model
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Model Summary

Deletion of Cacna1c leads to deficits in social behavior and pro-social 50-kHz ultrasonic communication in rats. Reduced levels of 50-kHz ultrasonic vocalizations emitted during rough-and-tumble play may suggest that Cacna1c haploinsufficient rats derive less reward from playful social interactions. Besides the emission of fewer 50-kHz ultrasonic vocalizations in the sender, Cacna1c deletion reduced social approach behavior elicited by playback of 50-kHz ultrasonic vocalizations. This indicates that Cacna1c haploinsufficiency has detrimental effects on 50-kHz ultrasonic communication in both, sender and receiver.

Reports related to CACNA1C (2 Reports)
# Type Title Author, Year
1 Primary Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats. Kisko TM , et al. (2018)
2 Additional Sex-specific effects of Cacna1c haploinsufficiency on object recognition, spatial memory, and reversal learning capabilities in rats. Braun MD , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

R_CACNA1C_1_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Cacna1c into Sprague Dawley embryos. The Cacna1c null allele carries a 4 base pair (bp) deletion at 460649- 460652 bp in genomic sequence resulting in an early stop codon in exon 6.

Allele Type: Knockout
Strain of Origin: Sprague Dawley
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Braun MD , et al. (2018)
Circadian sleep/wake cycle - Not Reported - - Kisko TM , et al. (2018)
Communications - Not Reported - - Braun MD , et al. (2018)
Communications Ultrasonic vocalization: Prosocial Decreased Reciprocal social interaction test 4 weeks Kisko TM , et al. (2018)
Developmental profile - Not Reported - - Braun MD , et al. (2018)
Developmental profile Size/growth No Change Body weight measurement 3, 4, 8 weeks Kisko TM , et al. (2018)
Emotion - Not Reported - - Braun MD , et al. (2018)
Emotion Fear response Decreased Radial maze test: white noise playback 3 weeks Kisko TM , et al. (2018)
Emotion Exploratory activity: Habituation No Change Radial maze test 3 weeks Kisko TM , et al. (2018)
Homeostasis - Not Reported - - Braun MD , et al. (2018)
Homeostasis - Not Reported - - Kisko TM , et al. (2018)
Immune response - Not Reported - - Braun MD , et al. (2018)
Immune response - Not Reported - - Kisko TM , et al. (2018)
Learning & memory Spatial working memory No Change Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory Spatial working memory Increased Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory Spatial reference memory No Change Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory Spatial reference memory Increased Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory Spatial learning No Change Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory Object recognition memory No Change Novel object recognition test 3 months Braun MD , et al. (2018)
Learning & memory Cognitive flexibility No Change Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory Cognitive flexibility Decreased Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Learning & memory - Not Reported - - Kisko TM , et al. (2018)
Maternal behavior - Not Reported - - Braun MD , et al. (2018)
Maternal behavior - Not Reported - - Kisko TM , et al. (2018)
Molecular profile - Not Reported - - Braun MD , et al. (2018)
Molecular profile Targeted protein expression Decreased Western blot 10 months Kisko TM , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Change Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity Decreased Eight-arm radial maze test 4 months Braun MD , et al. (2018)
Motor phenotype General locomotor activity No Change Novel cage test 2 months Kisko TM , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Braun MD , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Kisko TM , et al. (2018)
Neurophysiology - Not Reported - - Braun MD , et al. (2018)
Neurophysiology - Not Reported - - Kisko TM , et al. (2018)
Repetitive behavior - Not Reported - - Braun MD , et al. (2018)
Repetitive behavior Self grooming: perseveration No Change Novel cage test 2 months Kisko TM , et al. (2018)
Repetitive behavior Circling No Change Novel cage test 2 months Kisko TM , et al. (2018)
Seizure - Not Reported - - Braun MD , et al. (2018)
Seizure - Not Reported - - Kisko TM , et al. (2018)
Sensory - Not Reported - - Braun MD , et al. (2018)
Sensory - Not Reported - - Kisko TM , et al. (2018)
Social behavior - Not Reported - - Braun MD , et al. (2018)
Social behavior Social approach Decreased Radial maze test: Prosocial USV playback 3 weeks Kisko TM , et al. (2018)
Social behavior Juvenile play No Change Reciprocal social interaction test 4 weeks Kisko TM , et al. (2018)
CNVs associated with CACNA1C(1 Models)
12p13.33 30 Deletion-Duplication 46  /  198
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