Genetic Animal Models / CBLN1

CBLN1 Cerebellin 1 precursor

Model Species
Mus musculus
Gene Aliases
AI323299
Reports
3
Associated Human Genes
-
Models / Rescue Models
-
Rescue Model
-
Model Summary

Cbln1 homozygous knockout mice exhibit ataxia, a waddling gait, decreased motor coordination but no tremors. Although gross cerebellar morphology is intact, there is a decrease in the number of synapses of parallel fibers on Purkinje neurons and an increased in the number of climbing fiber terminals on Purkinje neurons with no change in the inhibitory glutamatergic and glycinergic synapses. Cbln1 homozygous knockout mice exhibit abnormal dendritic spines, and decreased excitatory EPSCs although intrinsic membrane properties are not altered.

Reports related to CBLN1 (3 Reports)
# Type Title Author, Year
1 Primary Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Hirai H , et al. (2005)
2 Additional Roles of Cbln1 in Non-Motor Functions of Mice. Otsuka S , et al. (2016)
3 Additional Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Krishnan V , et al. (2017)
Show all Construct Details Show all Phenotypic Profiles

M_CBLN1_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Homozygous cbln1 null mice were generated by homologous recombination using an 11.57kb HindIII-BamHI fragment containing the entire cbln1 gene, 5kb 5' upstream sequence, 2kb 3' downstream sequence, a neomycin resistance cassette inserted downstream of the cbln1 start codon, and a Herpes simplex thymidine kinase cassette inserted downstream of the stop codon, resulting in the frameshift deletion from the third nucleotide of codon 28.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: 16234806
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Reproductive function No change General observations Adult Hirai H , et al. (2005)
Circadian sleep/wake cycle - Not Reported - - Otsuka S , et al. (2016)
Circadian sleep/wake cycle - Not Reported - - Hirai H , et al. (2005)
Motor phenotype General locomotor activity: Ambulatory activity Decreased Open field test 3-5 month Otsuka S , et al. (2016)
Motor phenotype Ataxia Increased Accelerating rotarod test 1, 3-5 month Otsuka S , et al. (2016)
Motor phenotype Tremor No change General observations 2.5-13 weeks Hirai H , et al. (2005)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test Unreported Hirai H , et al. (2005)
Motor phenotype Gait Abnormal Footprint analysis 2 months Hirai H , et al. (2005)
Motor phenotype Ataxia Increased General observations 2.5-13 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Otsuka S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: Inhibitory No change Immunohistochemistry:vesicular GABA transmitter, VGAT (inhibitory synapses) Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density No change Immunohistochemistry: electron microscopy Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Decreased Electron microscopy Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size Increased Electron microscopy Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Purkinje cells No change Immunohistochemistry:Calbindin28K 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal migration No change Immunohistochemistry:Calbindin28K 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal migration Increased Immunohistochemistry Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine turnover Decreased Whole-cell patch clamp 2-2.5 months Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Abnormal Electron microscopy Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No change Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity No change Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: molecular layer thickness No change Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: granule cell layer thickness No change Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology No change Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar foliation No change Histology: Histology 4 weeks Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Anatomical projections and connectivity Abnormal Immunohistochemistry Unreported Hirai H , et al. (2005)
Neurophysiology - Not Reported - - Otsuka S , et al. (2016)
Neurophysiology Synaptic plasticity: cerebellar LTD Decreased Whole-cell patch clamp 3-4 weeks Hirai H , et al. (2005)
Neurophysiology Presynaptic function: vesicle recycling No change Electron microscopy Unreported Hirai H , et al. (2005)
Neurophysiology Presynaptic function: presynaptic fiber volley Decreased Whole-cell patch clamp 3-4 weeks, 2-2.5 months Hirai H , et al. (2005)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp Unreported Hirai H , et al. (2005)
Neurophysiology Presynaptic function: paired-pulse depression (PPD) No change Whole-cell patch clamp 3-4 weeks, 2-2.5 months Hirai H , et al. (2005)
Neurophysiology Miniature post synaptic current amplitude: excitatory Decreased Whole-cell patch clamp 3-4 weeks, 2-2.5 months Hirai H , et al. (2005)
Neurophysiology Ion influx and permeability: Calcium No change Whole-cell patch clamp 3-4 weeks Hirai H , et al. (2005)
Neurophysiology Intrinsic membrane properties No change Whole-cell patch clamp 3-4 weeks, 2-2.5 months Hirai H , et al. (2005)
Repetitive behavior - Not Reported - - Otsuka S , et al. (2016)
Repetitive behavior - Not Reported - - Hirai H , et al. (2005)
Seizure - Not Reported - - Otsuka S , et al. (2016)
Seizure - Not Reported - - Hirai H , et al. (2005)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 3-5 month Otsuka S , et al. (2016)
Sensory Pain or nociception No change Tail flick test 3-5 month Otsuka S , et al. (2016)
Sensory Pain or nociception Increased Foot shock test 3-5 month Otsuka S , et al. (2016)
Sensory - Not Reported - - Hirai H , et al. (2005)
Social behavior - Not Reported - - Otsuka S , et al. (2016)
Social behavior - Not Reported - - Hirai H , et al. (2005)
Communications - Not Reported - - Otsuka S , et al. (2016)
Communications - Not Reported - - Hirai H , et al. (2005)
Developmental profile Size/growth Decreased General observations Adult Otsuka S , et al. (2016)
Developmental profile Mortality/lethality No change General observations Adult Hirai H , et al. (2005)
Developmental profile General characteristics No change General observations Adult Hirai H , et al. (2005)
Emotion Fear response No change Response to olfactory stimuli 3-5 month Otsuka S , et al. (2016)
Emotion Anxiety Decreased Open field test 1, 3-5 month Otsuka S , et al. (2016)
Emotion - Not Reported - - Hirai H , et al. (2005)
Homeostasis - Not Reported - - Otsuka S , et al. (2016)
Homeostasis - Not Reported - - Hirai H , et al. (2005)
Immune response - Not Reported - - Otsuka S , et al. (2016)
Immune response - Not Reported - - Hirai H , et al. (2005)
Learning & memory Cued or contextual fear conditioning: Memory of cue: Short-term memory Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of cue Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of context: Short-term memory Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of context Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory - Not Reported - - Hirai H , et al. (2005)
Maternal behavior - Not Reported - - Otsuka S , et al. (2016)
Maternal behavior - Not Reported - - Hirai H , et al. (2005)
Molecular profile - Not Reported - - Otsuka S , et al. (2016)
Molecular profile Targeted expression Decreased Northern blot Not reported Hirai H , et al. (2005)
Molecular profile Targeted expression Decreased Western blot Not reported Hirai H , et al. (2005)
Molecular profile Targeted expression Decreased Radioimmunoassay (RIA) Not reported Hirai H , et al. (2005)

M_CBLN1_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Heterozygous cbln1 null mice were generated by homologous recombination using an 11.57kb HindIII-BamHI fragment containing the entire cbln1 gene, 5kb 5' upstream sequence, 2kb 3' downstream sequence, a neomycin resistance cassette inserted downstream of the cbln1 start codon, and a Herpes simplex thymidine kinase cassette inserted downstream of the stop codon, resulting in the frameshift deletion from the third nucleotide of codon28.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: 16234806
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hirai H , et al. (2005)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test Unreported Hirai H , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hirai H , et al. (2005)
Neurophysiology - Not Reported - - Hirai H , et al. (2005)
Repetitive behavior - Not Reported - - Hirai H , et al. (2005)
Seizure - Not Reported - - Hirai H , et al. (2005)
Sensory - Not Reported - - Hirai H , et al. (2005)
Social behavior - Not Reported - - Hirai H , et al. (2005)
Communications - Not Reported - - Hirai H , et al. (2005)
Developmental profile - Not Reported - - Hirai H , et al. (2005)
Emotion - Not Reported - - Hirai H , et al. (2005)
Homeostasis - Not Reported - - Hirai H , et al. (2005)
Immune response - Not Reported - - Hirai H , et al. (2005)
Learning & memory - Not Reported - - Hirai H , et al. (2005)
Maternal behavior - Not Reported - - Hirai H , et al. (2005)
Molecular profile Targeted expression Decreased Northern blot Unreported Hirai H , et al. (2005)
Molecular profile Targeted expression Decreased Western blot Unreported Hirai H , et al. (2005)
Molecular profile Targeted expression Decreased Radioimmunoassay (RIA) Unreported Hirai H , et al. (2005)

M_CBLN1_3_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 3 of the Cbln1 gene using CamkII-Cre, in excitatory neurons of the forebrain

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: CD-1

Es cell line: C57BL/6N
Model Source: 27852787
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Otsuka S , et al. (2016)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 1, 3-5 month Otsuka S , et al. (2016)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 1, 3-5 month Otsuka S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Otsuka S , et al. (2016)
Neurophysiology - Not Reported - - Otsuka S , et al. (2016)
Repetitive behavior - Not Reported - - Otsuka S , et al. (2016)
Seizure - Not Reported - - Otsuka S , et al. (2016)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 3-5 month Otsuka S , et al. (2016)
Social behavior - Not Reported - - Otsuka S , et al. (2016)
Communications - Not Reported - - Otsuka S , et al. (2016)
Developmental profile Size/growth No change Body weight measurement 3-5 month Otsuka S , et al. (2016)
Developmental profile General characteristics No change General observations 3-5 month Otsuka S , et al. (2016)
Emotion Anxiety No change Open field test 1, 3-5 month Otsuka S , et al. (2016)
Homeostasis - Not Reported - - Otsuka S , et al. (2016)
Immune response - Not Reported - - Otsuka S , et al. (2016)
Learning & memory Spatial working memory No change Radial maze test 3-5 month Otsuka S , et al. (2016)
Learning & memory Spatial reference memory Decreased Radial maze test 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of cue: Short-term memory Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of cue Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of context: Short-term memory Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of context Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning No change Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Maternal behavior - Not Reported - - Otsuka S , et al. (2016)
Molecular profile Targeted expression Decreased Immunohistochemistry 3-5 month Otsuka S , et al. (2016)
Molecular profile Targeted expression Decreased Immunohistochemistry 1 month Otsuka S , et al. (2016)
Molecular profile Targeted expression No change Immunohistochemistry 1 month Otsuka S , et al. (2016)
Molecular profile Targeted expression No change Immunohistochemistry 3-5 month Otsuka S , et al. (2016)

M_CBLN1_4_CKO_HM_GranuleN

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 3 of the Cbln1 gene using Grin2C-cre knock-in mice (Miyazaki et al., 2012), predominantly in the granule neurons of the cerebellum

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: CD-1

Es cell line: C57BL/6N
Model Source: 27852787
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Otsuka S , et al. (2016)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 1 month Otsuka S , et al. (2016)
Motor phenotype General locomotor activity: Ambulatory activity Decreased Open field test 3-5 month Otsuka S , et al. (2016)
Motor phenotype Ataxia Increased Accelerating rotarod test 1, 3-5 month Otsuka S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Otsuka S , et al. (2016)
Neurophysiology - Not Reported - - Otsuka S , et al. (2016)
Repetitive behavior - Not Reported - - Otsuka S , et al. (2016)
Seizure - Not Reported - - Otsuka S , et al. (2016)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 3-5 month Otsuka S , et al. (2016)
Social behavior - Not Reported - - Otsuka S , et al. (2016)
Communications - Not Reported - - Otsuka S , et al. (2016)
Developmental profile Size/growth Decreased General observations 3-5 month Otsuka S , et al. (2016)
Emotion Anxiety Decreased Open field test 3-5 month Otsuka S , et al. (2016)
Emotion Anxiety No change Open field test 1 month Otsuka S , et al. (2016)
Homeostasis - Not Reported - - Otsuka S , et al. (2016)
Immune response - Not Reported - - Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of cue: Short-term memory Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of cue Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of context: Short-term memory Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning: Memory of context Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test 1, 3-5 month Otsuka S , et al. (2016)
Maternal behavior - Not Reported - - Otsuka S , et al. (2016)
Molecular profile Targeted expression Decreased Immunohistochemistry 1, 3-5 month Otsuka S , et al. (2016)
Molecular profile Targeted expression No change Immunohistochemistry 1, 3-5 month Otsuka S , et al. (2016)

M_CBLN1_5_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 1 -2 of the Cbln1 using Vglut2-cre, in Vglut2 expressing neurons of the thalamus, midbrain and brainstem.A viral vector containing the channel rhodopsin AAV-DIO-Chr2-eYFP was injected into the VTA of these Vglut2-Cbln1 conditional knockout mice as a reporter

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: FVB/NJ

Es cell line: -
Model Source: 20537373
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Krishnan V , et al. (2017)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 7-11 weeks Krishnan V , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 7-11 weeks Krishnan V , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Krishnan V , et al. (2017)
Neurophysiology Synaptic transmission: excitatory Decreased Whole-cell patch clamp: medium spiny neurons - Krishnan V , et al. (2017)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 7-11 weeks Krishnan V , et al. (2017)
Seizure - Not Reported - - Krishnan V , et al. (2017)
Sensory Olfaction No change Buried food test 7-11 weeks Krishnan V , et al. (2017)
Social behavior Social interaction Decreased Reciprocal social interaction test 7-11 weeks Krishnan V , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 7-11 weeks Krishnan V , et al. (2017)
Communications Ultrasonic vocalization: Interaction induced: same sex stimulus Decreased Monitoring ultrasonic vocalizations: reciprocal interaction 7-11 weeks Krishnan V , et al. (2017)
Communications Ultrasonic vocalization: Interaction induced: opposite sex stimulus Decreased Monitoring ultrasonic vocalizations: reciprocal interaction 7-11 weeks Krishnan V , et al. (2017)
Developmental profile - Not Reported - - Krishnan V , et al. (2017)
Emotion Anxiety Decreased Elevated plus maze test 7-11 weeks Krishnan V , et al. (2017)
Homeostasis - Not Reported - - Krishnan V , et al. (2017)
Immune response - Not Reported - - Krishnan V , et al. (2017)
Learning & memory - Not Reported - - Krishnan V , et al. (2017)
Maternal behavior - Not Reported - - Krishnan V , et al. (2017)
Molecular profile - Not Reported - - Krishnan V , et al. (2017)

M_CBLN1_6_CKO_HM_VTA

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 1-2 from the Cbln1 gene using a AAV-cre, injected stereotaxically into the ventral tegmental area (VTA) bilaterally, age of injection not indicated in the article). To study the effect on glutamatergic trasmission following loss of Cbln1 in the VTA, the Cbln1 fl/fl mice were first crossed with Ai32 mice that contain the Cre inducible form of a light activated excitatory opsin- channel rhodopsin-2 enabling light induced activation of axon terminals of medium spiny neurons of the nucleus accumbens. All behavioral experiments were conducted approximately 20 days after the surgery required for injections.

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: FVB/NJ

Es cell line: -
Model Source: 28297715
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Krishnan V , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 7-11 weeks Krishnan V , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Krishnan V , et al. (2017)
Neurophysiology Synaptic transmission: excitatory Decreased Whole-cell patch clamp: medium spiny neurons Not reported Krishnan V , et al. (2017)
Repetitive behavior - Not Reported - - Krishnan V , et al. (2017)
Seizure - Not Reported - - Krishnan V , et al. (2017)
Sensory - Not Reported - - Krishnan V , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 7-11 weeks Krishnan V , et al. (2017)
Communications - Not Reported - - Krishnan V , et al. (2017)
Developmental profile - Not Reported - - Krishnan V , et al. (2017)
Emotion - Not Reported - - Krishnan V , et al. (2017)
Homeostasis - Not Reported - - Krishnan V , et al. (2017)
Immune response - Not Reported - - Krishnan V , et al. (2017)
Learning & memory - Not Reported - - Krishnan V , et al. (2017)
Maternal behavior - Not Reported - - Krishnan V , et al. (2017)
Molecular profile - Not Reported - - Krishnan V , et al. (2017)

M_CBLN1_7_CKO_HM_VTA

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 1 and 2 of the Cbln1 gene, using AAV-cre containing Vglut2 promoter driven Cre, bilaterally injected into the ventral tegmental area, mice tested 28 days after injection of viral vector, age of injection not indicated in the article

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: FVB/NJ

Es cell line: -
Model Source: 28297715
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Krishnan V , et al. (2017)
Motor phenotype - Not Reported - - Krishnan V , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Krishnan V , et al. (2017)
Neurophysiology - Not Reported - - Krishnan V , et al. (2017)
Repetitive behavior - Not Reported - - Krishnan V , et al. (2017)
Seizure - Not Reported - - Krishnan V , et al. (2017)
Sensory - Not Reported - - Krishnan V , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test Not reported Krishnan V , et al. (2017)
Communications - Not Reported - - Krishnan V , et al. (2017)
Developmental profile - Not Reported - - Krishnan V , et al. (2017)
Emotion - Not Reported - - Krishnan V , et al. (2017)
Homeostasis - Not Reported - - Krishnan V , et al. (2017)
Immune response - Not Reported - - Krishnan V , et al. (2017)
Learning & memory - Not Reported - - Krishnan V , et al. (2017)
Maternal behavior - Not Reported - - Krishnan V , et al. (2017)
Molecular profile - Not Reported - - Krishnan V , et al. (2017)
CNVs associated with CBLN1(1 Models)
16q12.1 10 Deletion-Duplication 18  /  33
Submit New Gene

Report an Error