Genetic Animal Models / CHD5

CHD5 chromodomain helicase DNA binding protein 5

Model Species
Mus musculus
Gene Aliases
4930532L22Rik, AW060752, B230399N07Rik, CHD-5
Reports
1
Associated Human Genes
CHD5
Models / Rescue Models
-
Rescue Model
-
Model Summary

The forebrains of Chd5 homozygous knockout mice show altered gene expression of genes important in cellular development and signaling. Chd5 homozygous knockout mice exhibit abnormal social and communicative behavior and a decreased preference for novelty. Chd5 homozygous knockout mice show deficits in responding to the distress of a conspecific, but no change in explicit direct fear conditioning.

Reports related to CHD5 (1 Reports)
# Type Title Author, Year
1 Primary Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics. Pisansky MT , et al. (2017)
Show all Construct Details Show all Phenotypic Profiles

M_CHD5_1_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 2 of the Chd5 gene using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6 J

Es cell line: C57BL/6 J
Model Source: EUCOMM consortium
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Pisansky MT , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test Not reported Pisansky MT , et al. (2017)
Motor phenotype General locomotor activity No change Open field test Not reported Pisansky MT , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Pisansky MT , et al. (2017)
Neurophysiology - Not Reported - - Pisansky MT , et al. (2017)
Repetitive behavior - Not Reported - - Pisansky MT , et al. (2017)
Seizure - Not Reported - - Pisansky MT , et al. (2017)
Sensory Sensorimotor gating No change Prepulse inhibition Not reported Pisansky MT , et al. (2017)
Social behavior Social memory Decreased Three-chamber social approach test Not reported Pisansky MT , et al. (2017)
Social behavior Social fear conditioning: memory of context Decreased Fear conditioning test Not reported Pisansky MT , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test Not reported Pisansky MT , et al. (2017)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P6-12 Pisansky MT , et al. (2017)
Developmental profile Mortality/lethality: embryonic No change General observations P0 Pisansky MT , et al. (2017)
Developmental profile General characteristics No change General observations Not reported Pisansky MT , et al. (2017)
Emotion Response to novelty Decreased Habituation-dishabituation test Not reported Pisansky MT , et al. (2017)
Emotion Exploratory activity: Habituation No change Habituation-dishabituation test Not reported Pisansky MT , et al. (2017)
Emotion Anxiety Increased Open field test Not reported Pisansky MT , et al. (2017)
Emotion Anxiety No change Elevated plus maze test Not reported Pisansky MT , et al. (2017)
Homeostasis - Not Reported - - Pisansky MT , et al. (2017)
Immune response - Not Reported - - Pisansky MT , et al. (2017)
Learning & memory Object recognition memory Decreased Novel object recognition test Not reported Pisansky MT , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of cue No change Fear conditioning test Not reported Pisansky MT , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Memory of context No change Fear conditioning test Not reported Pisansky MT , et al. (2017)
Learning & memory Cued or contextual fear conditioning: Extinction No change Fear conditioning test Not reported Pisansky MT , et al. (2017)
Learning & memory Cued or contextual fear conditioning No change Fear conditioning test Not reported Pisansky MT , et al. (2017)
Maternal behavior - Not Reported - - Pisansky MT , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Adult Pisansky MT , et al. (2017)
Molecular profile Gene expression Abnormal RNA sequencing Not reported Pisansky MT , et al. (2017)
Molecular profile Gene expression Abnormal Quantitative PCR (qRT-PCR) Not reported Pisansky MT , et al. (2017)

M_CHD5_2_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 2 of the Chd5 gene using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6 J

Es cell line: C57BL/6 J
Model Source: EUCOMM consortium
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Pisansky MT , et al. (2017)
Motor phenotype - Not Reported - - Pisansky MT , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Pisansky MT , et al. (2017)
Neurophysiology - Not Reported - - Pisansky MT , et al. (2017)
Repetitive behavior - Not Reported - - Pisansky MT , et al. (2017)
Seizure - Not Reported - - Pisansky MT , et al. (2017)
Sensory - Not Reported - - Pisansky MT , et al. (2017)
Social behavior - Not Reported - - Pisansky MT , et al. (2017)
Communications - Not Reported - - Pisansky MT , et al. (2017)
Developmental profile - Not Reported - - Pisansky MT , et al. (2017)
Emotion - Not Reported - - Pisansky MT , et al. (2017)
Homeostasis - Not Reported - - Pisansky MT , et al. (2017)
Immune response - Not Reported - - Pisansky MT , et al. (2017)
Learning & memory - Not Reported - - Pisansky MT , et al. (2017)
Maternal behavior - Not Reported - - Pisansky MT , et al. (2017)
Molecular profile Targeted expression No change Western blot Adult Pisansky MT , et al. (2017)
CNVs associated with CHD5(1 Models)
1p36.31 14 Deletion-Duplication 20  /  33
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