CHD8 chromodomain helicase DNA binding protein 8
Model Species
Mus musculusGene Aliases
5830451P18Rik, AU015341, Duplin, HELSNF1, mKIAA1564Models / Rescue Models
38 / 8Rescue Model
-Model Summary
Chd8 null mice die in embryonic stages (E8.5-E12.5). Heterozygous Chd8 mutant mice display ASD-like behaviors such as increased anxiety, impaired social interaction and social memory, and increased perseveration. Chd8 hets also have decreased length of intestine, slower intestinal transit, and impaired sensory. Chd8 knockdown brains exhibit abnormal corticogenesis and also display increased anxiety and decreased social approach. The Wnt-beta-catenin signaling pathway is down-regulated in Chd8 knockdowns and the Chd8 related phenotypes can be rescued by expressing beta-catenin.
External Links
Reports related to CHD8 (15 Reports)
# | Type | Title | Author, Year |
---|---|---|---|
1 | Additional | CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. | Nishiyama M , et al. (2009) |
2 | Additional | Effects of high dietary sodium chloride content on performance and sodium and potassium balance in growing pigs. | Chittavong M , et al. (2013) |
3 | Primary | CHD8 haploinsufficiency results in autistic-like phenotypes in mice. | Katayama Y , et al. (2016) |
4 | Additional | Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. | Durak O , et al. (2016) |
5 | Additional | Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. | Platt RJ , et al. (2017) |
6 | Additional | Germline Chd8 haploinsufficiency alters brain development in mouse. | Gompers AL , et al. (2017) |
7 | Additional | Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice. | Suetterlin P , et al. (2018) |
8 | Additional | Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. | Zhao C , et al. (2018) |
9 | Additional | Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. | Jung H , et al. (2018) |
10 | Additional | Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life | Jiménez JA et al. (2020) |
11 | Additional | The autism-associated protein CHD8 is required for cerebellar development and motor function | Kawamura A et al. (2021) |
12 | Additional | Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice | Ellingford RA et al. (2021) |
13 | Additional | Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism | Cherepanov SM et al. (2021) |
14 | Additional | Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8 +/- mouse model of ASD-like behavior | Yu Y et al. (2022) |
15 | Additional | Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model | Jiménez JA et al. (2022) |
M_CHD8_10_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Mouse model with a Cas9 mediated heterozygous germline frameshift deletion of 5 bp nucleotides in exon 5.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6N
Es cell line: Not reported
Model Source: Nord laboratory, UC Davis (PMID 28671691)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Motor phenotype | General locomotor activity | No change | Open field test | 2-4 months | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology of the amygdala | Increased | Magnetic resonance imaging (mri) | 2-4 months | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Increased | Magnetic resonance imaging (mri) | 2-4 months | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | Increased | Magnetic resonance imaging (mri) | 2-4 months | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | No change | Histology | P7 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical lamination | No change | Immunohistochemistry | P0, p7 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Decreased | Immunohistochemistry | E14.5 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Increased | Immunohistochemistry | E14.5 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Decreased | Pulse-chase analysis | E14.5 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Increased | Edu incorporation | E13.5 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Histology | P0, p7 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Histology | P7 | Gompers AL , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Increased | Magnetic resonance imaging (mri) | 2-4 months | Gompers AL , et al. (2017) |
Neurophysiology | Functional magnetic resonance imaging: connectivity | No change | Magnetic resonance imaging (mri) | 2-4 months | Gompers AL , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | No change | Grooming behavior assessments | 2-4 months | Gompers AL , et al. (2017) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 2-4 months | Gompers AL , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Social behavior | Social interaction: opposite sex | No change | Reciprocal social interaction test | 2-4 months | Gompers AL , et al. (2017) |
Social behavior | Social approach | No change | Three-chamber social approach test | 2-4 months | Gompers AL , et al. (2017) |
Physiological parameters | Reproductive function | No change | General observations | Adult | Gompers AL , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | No change | Monitoring ultrasonic vocalizations | 2-4 months | Gompers AL , et al. (2017) |
Developmental profile | Size/growth | No change | Body weight measurement | 2-4 months | Gompers AL , et al. (2017) |
Developmental profile | Mortality/lethality | No change | General observations | Adult | Gompers AL , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 2-4 months | Gompers AL , et al. (2017) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Decreased | Fear conditioning test | 2-4 months | Gompers AL , et al. (2017) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Decreased | Fear conditioning test | 2-4 months | Gompers AL , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Gompers AL , et al. (2017) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | E14.5, p0, adult | Gompers AL , et al. (2017) |
Molecular profile | Targeted expression | Decreased | Western blot | E14.5, p0, adult | Gompers AL , et al. (2017) |
Molecular profile | Protein expression level evidence | Decreased | Western blot | P0 | Gompers AL , et al. (2017) |
Molecular profile | Gene expression | Decreased | Rna sequencing | E12.5, e14.5, e17.5 & p0 | Gompers AL , et al. (2017) |
Molecular profile | Gene expression | Abnormal | Rna sequencing | E12.5, e14.5, e17.5 p0, 2-4 months | Gompers AL , et al. (2017) |
M_CHD8_11_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Chd8 haploinsufficient mice with targeted deletion of exon3 genrated by inserting a loxP/FRT-PGK-gb2-Neo cassette 214 bp 3 of exon 3 and an additional single loxP site 5' of exon3. Chimeras were bred with Flpe deleter mice to excise the neo cassette and produce Chd8^flox/+ mice that were crossed with beta-actin-Cre mice. Cre-mediated deletion of loxP-flanked exon 3 results in an early frameshift and termination of translation at amino acid 419, that produces a protein that lacks all functional domains, equivalent to nonsense and frameshift mutations terminating CHD8 at amino acids 62 and 747 in patients.
Allele Type: Knockout
Strain of Origin: C57BL/6
Genetic Background: C57BL/6J
Es cell line: C57BL/6
Model Source: PMID 29668850
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Suetterlin P , et al. (2018) |
Motor phenotype | Spontaneous movement | Decreased | Home cage behavior | 2 weeks | Suetterlin P , et al. (2018) |
Motor phenotype | Righting response | Decreased | Righting reflex test | 2 weeks | Suetterlin P , et al. (2018) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | Adult | Suetterlin P , et al. (2018) |
Motor phenotype | Hypoactivity | Increased | Running wheel test | Adult | Suetterlin P , et al. (2018) |
Motor phenotype | Hypoactivity | Increased | Open field test | Adult | Suetterlin P , et al. (2018) |
Motor phenotype | Hyperactivity | Phenovalue | Home cage behavior | 2 weeks | Suetterlin P , et al. (2018) |
Motor phenotype | Grip strength | Decreased | Grip strength test | Adult | Suetterlin P , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: Inhibitory | Increased | Immunostaining | P20 | Ellingford RA et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: Excitatory | No change | Whole-cell current clamp | P14 | Ellingford RA et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal morphology | No change | Sholl analysis | P22 | Ellingford RA et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No change | Sholl analysis | P20, P14 | Ellingford RA et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | No change | Sholl analysis | P22 | Ellingford RA et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Increased | Magnetic resonance imaging (mri) | Adult | Suetterlin P , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | Increased | Magnetic resonance imaging (mri) | Adult | Suetterlin P , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | Increased | Magnetic resonance imaging (mri) | Adult | Suetterlin P , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | No change | Immunohistochemistry | E12.5, e16.5, p0 | Suetterlin P , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Magnetic resonance imaging (mri) | Adult, 0-5 weeks | Suetterlin P , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Decreased | Rna sequencing | P5 | Suetterlin P , et al. (2018) |
Neurophysiology | Synaptic transmission: inhibitory | Increased | Whole-cell voltage clamp | P20 | Ellingford RA et al. (2021) |
Neurophysiology | Synaptic transmission: excitatory | Decreased | Whole-cell voltage clamp | P20 | Ellingford RA et al. (2021) |
Neurophysiology | Synaptic transmission | Decreased | Whole-cell current clamp | P13-P15 | Ellingford RA et al. (2021) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | Increased | Paired-pulse ratio | P20 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Increased | Whole-cell voltage clamp | P20 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | Decreased | Whole-cell voltage clamp | P20-adult | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell voltage clamp | P20 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Decreased | Whole-cell voltage clamp | P14, P20, adult | Ellingford RA et al. (2021) |
Neurophysiology | Membrane potential | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | Intrinsic membrane properties | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | EPSP-spike relationship | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | Action potential property: threshold | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | Action potential property: half-width | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | Action potential property: firing rate | Decreased | Whole-cell current clamp | P20 | Ellingford RA et al. (2021) |
Neurophysiology | Action potential property: firing pattern | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | Action potential property: amplitude | No change | Whole-cell current clamp | P19-21 | Ellingford RA et al. (2021) |
Neurophysiology | Functional magnetic resonance imaging: connectivity | Increased | Functional magnetic resonance imaging (fmri)-resting state | Adult | Suetterlin P , et al. (2018) |
Repetitive behavior | Self grooming: perseveration | No change | Grooming behavior assessments | Adult | Suetterlin P , et al. (2018) |
Repetitive behavior | Repetitive digging | Decreased | Marble-burying test | Adult | Suetterlin P , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Suetterlin P , et al. (2018) |
Sensory | Olfaction | No change | Olfactory discrimination test | Adult | Suetterlin P , et al. (2018) |
Social behavior | Social interaction | Increased | Reciprocal social interaction test | Adult | Suetterlin P , et al. (2018) |
Social behavior | Social approach | Increased | Three-chamber social approach test | Adult | Suetterlin P , et al. (2018) |
Social behavior | Social approach | Increased | Olfactory habituation-dishabituation test | Adult | Suetterlin P , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Suetterlin P , et al. (2018) |
Communications | Ultrasonic vocalization: isolation induced | No change | Monitoring ultrasonic vocalizations | 2 weeks | Suetterlin P , et al. (2018) |
Developmental profile | Skeletal development: craniofacial | Decreased | Cranial computerized tomography (ct) scan | Adult | Suetterlin P , et al. (2018) |
Developmental profile | Size/growth | Decreased | Body weight measurement | P4-p35 | Suetterlin P , et al. (2018) |
Developmental profile | Developmental trajectory | Decreased | General observations | 2 weeks | Suetterlin P , et al. (2018) |
Emotion | Anxiety | No change | Light-dark exploration test | Adult | Suetterlin P , et al. (2018) |
Emotion | Anxiety | No change | Open field test | Adult | Suetterlin P , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Suetterlin P , et al. (2018) |
Learning & memory | Spatial reference memory | No change | Morris water maze test | Adult | Suetterlin P , et al. (2018) |
Learning & memory | Cognitive flexibility | No change | Morris water maze test | Adult | Suetterlin P , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Suetterlin P , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | E12.5, p5 | Suetterlin P , et al. (2018) |
Molecular profile | Gene expression | Abnormal | Rna sequencing | E12.5, p5 | Suetterlin P , et al. (2018) |
Molecular profile | Cell adhesion | Decreased | Rna sequencing | P5 | Suetterlin P , et al. (2018) |
M_CHD8_12_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 4 of the Chd8 gene (floxed mice produced by the CRISPR-Cas9 system) using Olig1-cre, in primitive oligodendrocyte precursor cells (OPCs) prior to expression of PDGFRa+ in OPCs
Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background: C57BL/6 * 129Sv
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Motor phenotype | Tremor | Increased | General observations | 3 weeks onwards | Zhao C , et al. (2018) |
Motor phenotype | Clasping reflex | Increased | General observations | 3 weeks onwards | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | No change | NA | P14 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | Electron microscopy | 2 weeks, p1 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | Microscopic analysis | 2 weeks, p1 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | In situ hybridization (ish) | 2 weeks, p1 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | Quantitative pcr (qrt-pcr) | P7 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Decreased | In situ hybridization (ish) | E14.5 - 2 weeks | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | No change | In situ hybridization (ish) | P1, p14 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Decreased | Immunohistochemistry | P1 | Zhao C , et al. (2018) |
Neurophysiology | Apoptosis: brain cells | Increased | Immunohistochemistry | Adult | Zhao C , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Seizure | Seizures | Increased | General observations | 2 weeks, 2.5 weeks | Zhao C , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | Apoptosis | No change | Immunohistochemistry | P1, p7 | Zhao C , et al. (2018) |
Communications | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Developmental profile | Mortality/lethality | Increased | General observations | 3 weeks | Zhao C , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Molecular profile | Targeted expression | No change | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Molecular profile | Protein-dna complex assembly | Decreased | Chromatin immunoprecipitation sequencing (chip-seq) | P7 | Zhao C , et al. (2018) |
Molecular profile | Protein-dna complex assembly | Decreased | Chromatin immunoprecipitation (chip) | P7 | Zhao C , et al. (2018) |
Molecular profile | Gene expression | Abnormal | Rna sequencing | P7 | Zhao C , et al. (2018) |
Molecular profile | Dna methylation | Decreased | Cpg methylomics analysis | P7 | Zhao C , et al. (2018) |
Molecular profile | Chromatin modification | Decreased | Assay for transposase-accessible chromatin with high-throughput sequencing (atac-seq) | P7 | Zhao C , et al. (2018) |
Molecular profile | Cell proliferation | No change | Immunohistochemistry | P1 | Zhao C , et al. (2018) |
Molecular profile | Cell proliferation | Decreased | Immunohistochemistry | P1 | Zhao C , et al. (2018) |
M_CHD8_12_CKO_HM_CPI-455
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Conditional knockout mice with selective ablation of Chd8 in the oligodendrocyte lineage were intraperitoneally injected with CPI-455, a blood-brain barrier-permeable, potent and selective inhibitor of the KDM5 subfamily of histone demethylases, between P1 and P7.
Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background: C57BL/6 * 129Sv
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Number of oligodendrocytes | Ameliorated | Immunohistochemistry | P7 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Ameliorated | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Communications | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Molecular profile | Dna methylation | Ameliorated | Cpg methylomics analysis | P7 | Zhao C , et al. (2018) |
Molecular profile | Cell differentiation | Ameliorated | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
M_CHD8_13_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 4 of the Chd8 gene (floxed mice produced by the CRISPR-Cas9 system) using PDGFRa-creERT, in oligodendrocyte precursor cells (OPCs) expressing PDGFRa by treatment with tamoxifen from P3-P7
Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background: C57BL/6 * 129Sv
Es cell line: -
Model Source: Ai6, Jax laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Number of oligodendrocytes | Decreased | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Number of oligodendrocytes | No change | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | Apoptosis | Increased | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Communications | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Molecular profile | Cell proliferation | No change | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Molecular profile | Cell differentiation | No change | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Molecular profile | Cell differentiation | Decreased | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
M_CHD8_14_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 4 of the Chd8 gene (floxed mice produced by the CRISPR-Cas9 system) using Synapsin1-cre, in neuronal cells
Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background: C57BL/6 * 129Sv
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Number of oligodendrocytes | No change | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | No change | Immunohistochemistry | P14 | Zhao C , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Communications | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Molecular profile | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
M_CHD8_15_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 4 of the Chd8 gene (floxed mice produced by the CRISPR-Cas9 system) using PDGFRa-creERT, in oligodendrocyte precursor cells (OPCs) expressing PDGFRa by treatment with tamoxifen at 8 weeks of age
Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background: C57BL/6 * 129Sv
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Number of oligodendrocytes | Decreased | Immunofluorescence staining | 10, 12 weeks | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | Electron microscopy | 10, 12 weeks | Zhao C , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Decreased | In situ hybridization (ish) | 10, 12 weeks | Zhao C , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Communications | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Zhao C , et al. (2018) |
Molecular profile | Cell proliferation | Decreased | Immunohistochemistry | 10, 12 weeks | Zhao C , et al. (2018) |
M_CHD8_16_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Mice carrying a heterozygous frameshift point mutation in Chd8 (N2373K) previously identified in humans (Asn2373fsX2) with ASD. Chd8^N2373K/+ mice express a C-terminally truncated protein.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Jung H , et al. (2018) |
Motor phenotype | Self grooming: artificial stress evoked | Increased | Grooming behavior assessments | 8-9 weeks | Jung H , et al. (2018) |
Motor phenotype | Motor learning | No change | Accelerating rotarod test | Adult | Jung H , et al. (2018) |
Motor phenotype | General locomotor activity: ambulatory activity | Decreased | Open field test | Adult | Jung H , et al. (2018) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 3.3 weeks | Jung H , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Post-synaptic density size: inhibitory synapses | No change | Immunohistochemistry | 3.3 weeks | Jung H , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Post-synaptic density size: excitatory synapses | No change | Immunohistochemistry | 3.3 weeks | Jung H , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | No change | Immunohistochemistry | 3.3 weeks | Jung H , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Magnetic resonance imaging (mri) | 4 weeks | Jung H , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Immunohistochemistry | 3.3 weeks | Jung H , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | No change | Diffusion tensor imaging (dti) | 4weeks | Jung H , et al. (2018) |
Neurophysiology | Synaptic transmission: inhibitory | No change | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Synaptic transmission: inhibitory | Increased | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Synaptic transmission: excitatory | Increased | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Synaptic transmission: excitatory | No change | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Spontaneous post synaptic event frequency: inhibitory currents | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Neuronal activation | Increased | Immunohistochemistry | P19-20 | Jung H , et al. (2018) |
Neurophysiology | Neuronal activation | Decreased | Immunohistochemistry | P19-20 | Jung H , et al. (2018) |
Neurophysiology | Neuronal activation | No change | Immunohistochemistry | P19-20 | Jung H , et al. (2018) |
Neurophysiology | Neuronal activation | No change | Immunohistochemistry | P19-20 | Jung H , et al. (2018) |
Neurophysiology | Neuronal activation | Decreased | Immunohistochemistry | P19-20 | Jung H , et al. (2018) |
Neurophysiology | Neuronal activation | Decreased | Immunohistochemistry | P19-20 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | No change | Whole-cell patch clamp | P22-p25 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Decreased | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Increased | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | No change | Whole-cell patch clamp | P22-p25 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | P22-p25 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | Decreased | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | P22-p25 | Jung H , et al. (2018) |
Neurophysiology | Local field potential | No change | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Intrinsic membrane properties | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Intrinsic bursting events or spikes | Increased | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Intrinsic bursting events or spikes | Decreased | Whole-cell patch clamp | 2-3 months | Jung H , et al. (2018) |
Neurophysiology | Action potential property: firing rate | No change | Whole-cell patch clamp | P19-27 | Jung H , et al. (2018) |
Neurophysiology | Action potential property: firing rate | No change | Whole-cell patch clamp | P22-p25 | Jung H , et al. (2018) |
Repetitive behavior | Vertical jumping or back flipping | No change | Home cage behavior | 3.3 weeks | Jung H , et al. (2018) |
Repetitive behavior | Self grooming: perseveration | No change | Home cage behavior | 3.3, 9 weeks | Jung H , et al. (2018) |
Repetitive behavior | Repetitive nose pokes | No change | Hole-board test | 10 weeks | Jung H , et al. (2018) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 10 weeks | Jung H , et al. (2018) |
Repetitive behavior | Repetitive digging | No change | Home cage behavior | 3.3 weeks | Jung H , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Jung H , et al. (2018) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | Adult | Jung H , et al. (2018) |
Sensory | Olfaction | No change | Olfactory discrimination test | Adult | Jung H , et al. (2018) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | Adult | Jung H , et al. (2018) |
Social behavior | Social approach | No change | Three-chamber social approach test | Adult | Jung H , et al. (2018) |
Social behavior | Social approach | Increased | Home cage behavior | 2.7 weeks | Jung H , et al. (2018) |
Social behavior | Nest building behavior | No change | Nest building assay | Adult | Jung H , et al. (2018) |
Social behavior | Juvenile play | No change | Home cage behavior | 3.3 weeks | Jung H , et al. (2018) |
Social behavior | Huddling behavior | No change | Home cage behavior | Adult | Jung H , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Jung H , et al. (2018) |
Communications | Ultrasonic vocalization: isolation induced | Increased | Monitoring ultrasonic vocalizations | P5, p7, p9, p11 | Jung H , et al. (2018) |
Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | No change | Monitoring ultrasonic vocalizations | Adult | Jung H , et al. (2018) |
Developmental profile | Size/growth | No change | Body weight measurement | P7, p10, p13, p16, p21 | Jung H , et al. (2018) |
Developmental profile | Mortality/lethality | No change | Survival analysis | P0 | Jung H , et al. (2018) |
Emotion | Depression | No change | Tail suspension test | Adult | Jung H , et al. (2018) |
Emotion | Anxiety | No change | Elevated plus maze test | Adult | Jung H , et al. (2018) |
Emotion | Anxiety | No change | Light-dark exploration test | Adult | Jung H , et al. (2018) |
Emotion | Anxiety | Decreased | Open field test | Adult | Jung H , et al. (2018) |
Emotion | Anxiety | No change | Open field test | 3.3 weeks | Jung H , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Jung H , et al. (2018) |
Learning & memory | Spatial working memory | No change | Morris water maze test | Adult | Jung H , et al. (2018) |
Learning & memory | Spatial reference memory | No change | Morris water maze test | Adult | Jung H , et al. (2018) |
Learning & memory | Object recognition memory | No change | Novel object recognition test | Adult | Jung H , et al. (2018) |
Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | Adult | Jung H , et al. (2018) |
Learning & memory | Cognitive flexibility | No change | Morris water maze test | Adult | Jung H , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Jung H , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Western blot | E15.5-p7 | Jung H , et al. (2018) |
Molecular profile | Protein expression level evidence | No change | Whole-cell patch clamp | P2 | Jung H , et al. (2018) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | P0 | Jung H , et al. (2018) |
Molecular profile | Gene expression | Abnormal | Quantitative pcr (qrt-pcr) | P25 | Jung H , et al. (2018) |
M_CHD8_17_KI_HM_V984STOP
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mice harboring an insertion introducing tandem stop codons at amino acid positions v986 and e987 (v986*; stop codon mutation)
Allele Type: ASD mutation
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Mark J. Zylka Lab (PMID 33023670)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Developmental profile | Mortality/lethality: embryonic | Increased | Survival analysis | P0 | Jiménez JA et al. (2020) |
M_CHD8_18_KI_HT_V984STOP
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Mice harboring an insertion introducing tandem stop codons at amino acid positions V986 and E987 (V986*; stop codon mutation)
Allele Type: ASD mutation
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Mark J. Zylka Lab (PMID 33023670)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Rearing behavior | Decreased | Open field test | week 52 | Jiménez JA et al. (2022) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | week 52 | Jiménez JA et al. (2022) |
Motor phenotype | Rearing behavior | Decreased | Open field test | 6.3 months, 12.4 months | Jiménez JA et al. (2020) |
Motor phenotype | General locomotor activity: Ambulatory activity | No change | Open field test | 6.3 months, 12.4 months | Jiménez JA et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | P0 | Jiménez JA et al. (2020) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 6.8 weeks | Jiménez JA et al. (2020) |
Sensory | Startle response: acoustic stimulus | No change | Acoustic startle reflex test | 6.8 weeks | Jiménez JA et al. (2020) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | 6.8 weeks | Jiménez JA et al. (2020) |
Sensory | Olfaction | No change | Buried food test | 6.8 weeks | Jiménez JA et al. (2020) |
Social behavior | Social memory | No change | Three-chamber social approach test | week 26 | Jiménez JA et al. (2022) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | week 52 | Jiménez JA et al. (2022) |
Social behavior | Social approach | No change | Three-chamber social approach test | week 52 | Jiménez JA et al. (2022) |
Social behavior | Social approach | Increased | Three-chamber social approach test | week 26 | Jiménez JA et al. (2022) |
Social behavior | Social memory | Increased | Three-chamber social approach test | 6.6 months, 12.9 months | Jiménez JA et al. (2020) |
Social behavior | Social interaction | Increased | Tube test of social dominance | 8-10 weeks | Jiménez JA et al. (2020) |
Social behavior | Social approach | Increased | Three-chamber social approach test | 6.6 months, 12.9 months | Jiménez JA et al. (2020) |
Developmental profile | Tissue weight | Increased | Measurement of placental weight | E15 | Jiménez JA et al. (2022) |
Developmental profile | Size/growth | Increased | Body weight measurement | E15 | Jiménez JA et al. (2022) |
Developmental profile | Size/growth | Decreased | Body weight measurement | P0, 5.9 weeks | Jiménez JA et al. (2020) |
Developmental profile | Developmental trajectory | Abnormal | RNA sequencing | P0-Adult | Jiménez JA et al. (2020) |
Emotion | Anxiety | No change | Open field test | week 52 | Jiménez JA et al. (2022) |
Emotion | Anxiety | Increased | Elevated plus maze test | week 26, week 52 | Jiménez JA et al. (2022) |
Emotion | Anxiety | No change | Elevated plus maze test | 6 months | Jiménez JA et al. (2020) |
Emotion | Anxiety | Increased | Open field test | 6.3 months, 12.4 months | Jiménez JA et al. (2020) |
Molecular profile | Gene expression | No change | RNA sequencing | E15, week 52 | Jiménez JA et al. (2022) |
Molecular profile | Differential gene expression | Abnormal | Quantitative PCR (qRT-PCR) | week 6 | Jiménez JA et al. (2022) |
Molecular profile | Differential gene expression | Abnormal | RNA sequencing | E15, week 52 | Jiménez JA et al. (2022) |
Molecular profile | Targeted expression | Decreased | Western blot | P0 | Jiménez JA et al. (2020) |
Molecular profile | Targeted expression | Decreased | RNA sequencing | E14.5, 1, 6, 12 months | Jiménez JA et al. (2020) |
Molecular profile | Signaling: UPR pathway | Decreased | Immunofluorescence staining | 12 month | Jiménez JA et al. (2020) |
Molecular profile | Signaling: mTOR pathway | Decreased | RNA sequencing | E14.5, 1, 6, 12 months | Jiménez JA et al. (2020) |
Molecular profile | Signaling: mTOR pathway | Decreased | Immunofluorescence staining | 12 month | Jiménez JA et al. (2020) |
Molecular profile | Differential gene expression | Abnormal | RNA sequencing | E14.5, 1, 6, 12 months | Jiménez JA et al. (2020) |
M_CHD8_19_CKO_HM
Model Type: Genetic LOF
Model Genotype: Homozygous
Mutation:
Nestin-cre/chd8l^f/f cko mice with neural precursor or stem cell specific deletion of chd8 were generated by crossing chd8l^f/f mice with pair of loxp sites flanking exons 11 to 13 was to nestin cre recombinase mice. offspring were backcrossed onto the c57bl/6j line for at least nine generations.
Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: C57BL/6J
Es cell line: Not reported
Model Source: Not reported
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neuroanatomy / Ultrastructure / Cytoarchitecture | Mortality/lethality: postnatal: incomplete penetrance | Increased | Kaplan-Meier survival curve | P0-1 month | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | Decreased | Histology | P0, P7, P14 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | Decreased | Gross necroscopy | Adult | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar foliation | Decreased | Histology | P0, P7, P14 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Gross necroscopy | Adult | Kawamura A et al. (2021) |
Developmental profile | Size/growth | Decreased | Body weight measurement | P14 | Kawamura A et al. (2021) |
Molecular profile | Targeted expression | Decreased | Quantitative PCR (qRT-PCR) | P0, P3, P7, P14 | Kawamura A et al. (2021) |
M_CHD8_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Targeted deletion of all the exons of the Chd8 gene.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6
Es cell line: Not specified
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Communications | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Developmental profile | Size/growth | Decreased | Histology | Unreported | Nishiyama M , et al. (2009) |
Developmental profile | Mortality/lethality: embryonic | Increased | General observations | E5.5-e10.5 | Nishiyama M , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
Molecular profile | NA | Not reported | NA | NA | Nishiyama M , et al. (2009) |
M_CHD8_1_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Targeted deletion of all the exons of the Chd8 gene.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6
Es cell line: Not specified
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Motor phenotype | General locomotor activity: Ambulatory activity | No change | Open field test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Motor phenotype | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Measurement of tissue weight | E14.5 | Katayama Y , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | E18.5; 9 weeks | Katayama Y , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Cranial computerized tomography (ct) scan | E18.5; 9 weeks | Katayama Y , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Social behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Physiological parameters | Bioactive compound levels | No change | Enzyme assay | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Physiological parameters | Bioactive compound levels | Decreased | Enzyme assay | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Physiological parameters | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Physiological parameters | Digestive system function: gastrointestinal motility | No change | Measurement of gi motility | 9 weeks | Katayama Y , et al. (2016) |
Communications | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Developmental profile | Digestive system development | Decreased | General observations | 9 weeks | Katayama Y , et al. (2016) |
Emotion | Depression | No change | Tail suspension test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Depression | No change | Open field test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Depression | No change | Sucrose preference test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Depression | Increased | Open field test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Depression | Increased | Open field test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Depression | Increased | Tail suspension test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Depression | Decreased | Sucrose preference test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Anxiety | Increased | Light-dark exploration test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Anxiety | No change | Open field test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Anxiety | Decreased | Modified open field test with social object | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Anxiety | Increased | Elevated plus maze test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Maternal behavior | Pup retrieval | No change | Pup retrieval assay | Adult | Cherepanov SM et al. (2021) |
Maternal behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | No change | Western blot | E10.5 and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | No change | Quantitative pcr (qrt-pcr) | E10.5 and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | Decreased | Western blot | E10.5, e14.5, e18.5, and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | E10.5, e14.5, e18.5, and 9 weeks | Katayama Y , et al. (2016) |
M_CHD8_1_KO_HT_OXT
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Targeted deletion of all the exons of the chd8 gene. mice were administered saline or ot (100 ng/100 g of body weight), approximately 0.3 ml per mice intraperitoneally (i.p.), 30 min before the start of experiments.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6
Es cell line: Not specified
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Social behavior | Social memory | Ameliorated | Three-chamber social approach test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Anxiety | Refractory | Light-dark exploration test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
Emotion | Anxiety | Restored | Light-dark exploration test | 8ââ¬â12 weeks | Cherepanov SM et al. (2021) |
M_CHD8_20_CKO_HT
Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation:
Nestin-cre/chd8l^f/+ cko mice with neural precursor or stem cell specific deletion of chd8 were generated by crossing chd8l^f/+ mice with pair of loxp sites flanking exons 11 to 13 was to nestin cre recombinase mice. offspring were backcrossed onto the c57bl/6j line for at least nine generations.
Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: C57BL/6J
Es cell line: Not reported
Model Source: Not reported
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neuroanatomy / Ultrastructure / Cytoarchitecture | Mortality/lethality: postnatal: incomplete penetrance | No change | Kaplan-Meier survival curve | P0-1 month | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Gross necroscopy | Adult | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | P0, P7, P14 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar foliation | No change | Histology | P0, P7, P14 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Gross necroscopy | Adult | Kawamura A et al. (2021) |
Developmental profile | Size/growth | No change | General observations | P14 | Kawamura A et al. (2021) |
Molecular profile | Targeted expression | Decreased | Quantitative PCR (qRT-PCR) | P0, P3, P7, P14 | Kawamura A et al. (2021) |
M_CHD8_21_CKO_HM
Model Type: Genetic LOF
Model Genotype: Homozygous
Mutation:
Atoh1-cre/chd8l^f/f cko mice with granule neuron progenitor-specific deletion of chd8 were generated by crossing chd8l^f/f mice with pair of loxp sites flanking exons 11 to 13 was to nestin cre recombinase mice. offspring were backcrossed onto the c57bl/6j line for at least nine generations.
Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: C57BL/6J
Es cell line: Not reported
Model Source: Not reported
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor learning | No change | Accelerating rotarod test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | No change | Wire hang test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | Decreased | Balance beam test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | Decreased | Accelerating rotarod test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Grip strength | No change | Grip strength test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity: Ambulatory activity | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: Excitatory | Decreased | Immunostaining | 5-6 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: AMPA receptors | Decreased | Western blot | P7 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Increased | Immunostaining | P0, P3 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Sholl analysis | 8-10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology: granule cell layer thickness | Decreased | Histology | P0-Adult | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | Decreased | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | Abnormal | Immunostaining | 10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors: granule cell precursors | Decreased | Quantitative PCR (qRT-PCR) | P0 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Decreased | Immunostaining | P0, P3, P7, P14 | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Gross necroscopy | Adult | Kawamura A et al. (2021) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | Increased | Whole-cell patch clamp | P21, P40 | Kawamura A et al. (2021) |
Neurophysiology | Neuronal apoptosis | No change | Immunostaining | P0, P3 | Kawamura A et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Decreased | Whole-cell patch clamp | P21, P40 | Kawamura A et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | No change | Whole-cell patch clamp | P21, P40 | Kawamura A et al. (2021) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | Decreased | Whole-cell patch clamp | P21, P40 | Kawamura A et al. (2021) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Decreased | Whole-cell patch clamp | P21, P40 | Kawamura A et al. (2021) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 8-10 weeks | Kawamura A et al. (2021) |
Sensory | Hearing | No change | Auditory brainstem response test | 8 weeks | Kawamura A et al. (2021) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Developmental profile | Size/growth | No change | Body weight measurement | 9-13 weeks | Kawamura A et al. (2021) |
Developmental profile | Developmental trajectory | No change | Immunostaining | P7 | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
Molecular profile | Differential gene expression | Abnormal | RNA sequencing | P7 | Kawamura A et al. (2021) |
Molecular profile | Chromatin modification: Histone modification: Open chromatin | Decreased | Formaldehyde-assisted isolation of regulatory elements (FAIRE) | P7 | Kawamura A et al. (2021) |
M_CHD8_22_CKO_HT
Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation:
Atoh1-cre/chd8l^f/+ cko mice with granule neuron progenitor-specific deletion of chd8 were generated by crossing chd8l^f/+ mice with pair of loxp sites flanking exons 11 to 13 was to nestin cre recombinase mice. offspring were backcrossed onto the c57bl/6j line for at least nine generations.
Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: C57BL/6J
Es cell line: Not reported
Model Source: Not reported
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor learning | No change | Accelerating rotarod test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | No change | Balance beam test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | No change | Wire hang test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Grip strength | No change | Grip strength test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity: Ambulatory activity | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | No change | Sholl analysis | 8-10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Immunostaining | 10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | P0-Adult | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Gross necroscopy | Adult | Kawamura A et al. (2021) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Developmental profile | Size/growth | No change | Body weight measurement | 9-13 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
M_CHD8_23_CKO_HM
Model Type: Genetic LOF
Model Genotype: Homozygous
Mutation:
Pcp2-cre/chd8l^f/f cko mice with purkinje-cell-specific deletion of chd8 were generated by crossing chd8l^f/f mice with pair of loxp sites flanking exons 11 to 13 was to nestin cre recombinase mice. offspring were backcrossed onto the c57bl/6j line for at least nine generations.
Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: C57BL/6J
Es cell line: Not reported
Model Source: Not reported
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor coordination and balance | No change | Balance beam test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | No change | Wire hang test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Grip strength | No change | Grip strength test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity: Ambulatory activity | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: Purkinje cells | No change | Immunostaining | 10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Immunostaining | 10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | 10 weeks | Kawamura A et al. (2021) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Developmental profile | Size/growth | No change | Body weight measurement | 9-13 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
M_CHD8_24_CKO_HT
Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation:
Pcp2-cre/chd8l^f/+ cko mice with purkinje-cell-specific deletion of chd8 were generated by crossing chd8l^f/+ mice with pair of loxp sites flanking exons 11 to 13 was to nestin cre recombinase mice. offspring were backcrossed onto the c57bl/6j line for at least nine generations.
Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: C57BL/6J
Es cell line: Not reported
Model Source: Not reported
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor coordination and balance | No change | Balance beam test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Motor coordination and balance | No change | Wire hang test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | Grip strength | No change | Grip strength test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity: Ambulatory activity | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Motor phenotype | General locomotor activity | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: Purkinje cells | No change | Immunostaining | 10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Immunostaining | 10 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Measurement of tissue weight | 9-13 weeks | Kawamura A et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | 10 weeks | Kawamura A et al. (2021) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | 8-10 weeks | Kawamura A et al. (2021) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8-10 weeks | Kawamura A et al. (2021) |
Developmental profile | Size/growth | No change | Body weight measurement | 9-13 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Open field test | 8-10 weeks | Kawamura A et al. (2021) |
Emotion | Anxiety | No change | Elevated plus maze test | 8-10 weeks | Kawamura A et al. (2021) |
M_CHD8_25_CKO_HT
Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation:
Chd8^flox mice were bred with nkx2.1-cre mice to excise exon 3, resulting in an early frameshift and termination of translation at amino acid 419 (chd8ââ¬â) to produce a protein lacking all functional domains, in inhibitory interneurons, equivalent to nonsense and frameshift mutations identified in patients.
Allele Type: Conditional knockout
Strain of Origin: C57BL/6JÃÂ
Genetic Background: C57BL/6JÃÂ
Es cell line: C57BL/6JÃÂ
Model Source: 29668850
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Increased | Whole-cell current clamp | P19-P21 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | No change | Whole-cell current clamp | P19-P21 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell current clamp | P19-P21 | Ellingford RA et al. (2021) |
M_CHD8_26_CKO_HT
Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation:
Chd8^flox mice were bred with nex cre mice to excise exon 3, resulting in an early frameshift and termination of translation at amino acid 419 (chd8ââ¬â) to produce a protein lacking all functional domains in forebrain postmitotic excitatory neurons, equivalent to nonsense and frameshift mutations identified in patients.
Allele Type: Conditional knockout
Strain of Origin: C57BL/6JÃÂ
Genetic Background: C57BL/6JÃÂ
Es cell line: C57BL/6JÃÂ
Model Source: 29668850
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Decreased | Whole-cell current clamp | P19-P21 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | Decreased | Whole-cell current clamp | P19-P21 | Ellingford RA et al. (2021) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Increased | Whole-cell current clamp | P19-P21 | Ellingford RA et al. (2021) |
M_CHD8_27_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
A 13 bp deletion in exon 1 of CHD8 resulted in a premature stop codon
Allele Type: knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Nanjing Biomedical Research Institute (PMID 35241668)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | week 8-14 | Yu Y et al. (2022) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Satiety response | No change | Food intake measurements | unreported | Yu Y et al. (2022) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Digestive system morphology: GI tract length | Decreased | Gross necroscopy | week 12 | Yu Y et al. (2022) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | week 12 | Yu Y et al. (2022) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Blood brain barrier permeability | No change | Blood brain barrier integrity test | week 8-9 | Yu Y et al. (2022) |
Neurophysiology | Neurotransmitter release: neurohypophysial | No change | Immunofluorescence staining | week 12 | Yu Y et al. (2022) |
Neurophysiology | Neurotransmitter release: glutamate | Increased | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Neurophysiology | Neurotransmitter release: gaba | No change | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Decreased | Whole-cell patch clamp | week 8-9 | Yu Y et al. (2022) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | Increased | Whole-cell patch clamp | week 8-9 | Yu Y et al. (2022) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | week 8-9 | Yu Y et al. (2022) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | week 8-9 | Yu Y et al. (2022) |
Neurophysiology | Amino acid levels: brain | Abnormal | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Repetitive behavior | Self grooming | No change | Grooming behavior assessments | week 8-14 | Yu Y et al. (2022) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | week 8-14 | Yu Y et al. (2022) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | week 8-14 | Yu Y et al. (2022) |
Social behavior | Social approach | No change | Three-chamber social approach test | week 8-14 | Yu Y et al. (2022) |
Physiological parameters | Intestinal microbiota composition: functional profile | Abnormal | 16S rRNA gene sequence analysis for identification of bacteria | week 8 | Yu Y et al. (2022) |
Physiological parameters | Intestinal microbiota composition | Decreased | 16S rRNA gene sequence analysis for identification of bacteria | week 8 | Yu Y et al. (2022) |
Physiological parameters | Digestive system function: intestinal barrier: intestinal permeability | No change | Intestinal permeability test | week 12 | Yu Y et al. (2022) |
Physiological parameters | Digestive system function: gastrointestinal motility | No change | Measurement of GI motility | week 12 | Yu Y et al. (2022) |
Physiological parameters | Bioactive compound levels: short chain fatty acids | No change | High-performance liquid chromatography (HPLC) | week 8 | Yu Y et al. (2022) |
Physiological parameters | Bioactive compound levels | Increased | ELISA | week 12 | Yu Y et al. (2022) |
Developmental profile | Size/growth | Decreased | Body weight measurement | week 4, week 12, week 18 | Yu Y et al. (2022) |
Developmental profile | Digestive system morphology: intestine | Abnormal | Measurement of tissue weight | week 12 | Yu Y et al. (2022) |
Emotion | Depression | No change | Forced swim test | week 8-14 | Yu Y et al. (2022) |
Emotion | Anxiety | Increased | Light-dark exploration test | week 8-14 | Yu Y et al. (2022) |
Emotion | Anxiety | Increased | Open field test | week 8-14 | Yu Y et al. (2022) |
Immune response | Cytokine levels | Increased | ELISA | week 12 | Yu Y et al. (2022) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | week 8-14 | Yu Y et al. (2022) |
Molecular profile | Targeted expression | Decreased | Western blot | E 14.5, week 12 | Yu Y et al. (2022) |
Molecular profile | Protein expression: in situ protein expression | Increased | Immunofluorescence staining | week 12 | Yu Y et al. (2022) |
Molecular profile | Protein expression level evidence | Increased | Western blot | week 12 | Yu Y et al. (2022) |
Molecular profile | Gene expression | No change | RNA sequencing | week 12 | Yu Y et al. (2022) |
Molecular profile | Gene expression | Increased | RNA sequencing | week 12 | Yu Y et al. (2022) |
Molecular profile | Amino acid levels | Decreased | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Molecular profile | Amino acid levels | Increased | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
M_CHD8_27_KO_HT_BUNIFORMIS
Model Type: RESCUE-Dietary
Model Genotype: Heterozygous
Mutation:
Treated weaned Chd8 heterozygous mice by gavage with Bacteroides uniformis every 3 days for 4 weeks and then examined the effects of this treatment
Allele Type: knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Nanjing Biomedical Research Institute (PMID 35241668)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neurophysiology | Neurotransmitter release: glutamate | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | Restored | Whole-cell patch clamp | week 8-9 | Yu Y et al. (2022) |
Neurophysiology | Amino acid levels: brain | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Social behavior | Social memory | Restored | Three-chamber social approach test | week 8-14 | Yu Y et al. (2022) |
Physiological parameters | Intestinal microbiota composition | Restored | Quantitative PCR (qRT-PCR) | week 8 | Yu Y et al. (2022) |
Emotion | Anxiety | Restored | Light-dark exploration test | week 8-14 | Yu Y et al. (2022) |
Emotion | Anxiety | Restored | Open field test | week 8-14 | Yu Y et al. (2022) |
Learning & memory | Object recognition memory | Refractory | Novel object recognition test | week 8-14 | Yu Y et al. (2022) |
Molecular profile | Protein expression: in situ protein expression | Restored | Immunofluorescence staining | week 12 | Yu Y et al. (2022) |
Molecular profile | Protein expression level evidence | Ameliorated | Western blot | week 12 | Yu Y et al. (2022) |
Molecular profile | Gene expression | Ameliorated | RNA sequencing | week 12 | Yu Y et al. (2022) |
Molecular profile | Differential gene expression | Ameliorated | RNA sequencing | week 8 | Yu Y et al. (2022) |
Molecular profile | Amino acid levels | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Molecular profile | Amino acid levels | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
M_CHD8_27_KO_HT_COHOUSING
Model Type: RESCUE-Behavioral
Model Genotype: Heterozygous
Mutation:
Chd8 wildtype and heterozygous mice were co-housed mice after weaning in a 3:1 ratio for 4 weeks.
Allele Type: knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Nanjing Biomedical Research Institute (PMID 35241668)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Social behavior | Social memory | Restored | Three-chamber social approach test | week 8-14 | Yu Y et al. (2022) |
Physiological parameters | Intestinal microbiota composition | Restored | Quantitative PCR (qRT-PCR) | week 8 | Yu Y et al. (2022) |
Emotion | Anxiety | Ameliorated | Light-dark exploration test | week 8-14 | Yu Y et al. (2022) |
Learning & memory | Object recognition memory | Refractory | Novel object recognition test | week 8-14 | Yu Y et al. (2022) |
M_CHD8_27_KO_HT_SBLC
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
S-benzyl-L-cysteine, a SLC6A19 inhibitor, was added to the drinking water of weaning Chd8 heterozygous mice for 4 weeks
Allele Type: knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Nanjing Biomedical Research Institute (PMID 35241668)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neurophysiology | Neurotransmitter release: glutamate | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Neurophysiology | Amino acid levels: brain | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
Social behavior | Social memory | Restored | Three-chamber social approach test | week 8 | Yu Y et al. (2022) |
Emotion | Anxiety | Restored | Open field test | week 8 | Yu Y et al. (2022) |
Emotion | Anxiety | Restored | Light-dark exploration test | week 8 | Yu Y et al. (2022) |
Learning & memory | Object recognition memory | Refractory | Novel object recognition test | week 8 | Yu Y et al. (2022) |
Molecular profile | Amino acid levels | Restored | High-performance liquid chromatography (HPLC) | week 12 | Yu Y et al. (2022) |
M_CHD8_28_KI_HT_V984STOP_DM
Model Type: Multifactorial
Model Genotype: Heterozygous
Mutation:
Mice harboring an insertion introducing tandem stop codons at amino acid positions V986 and E987 (V986*; stop codon mutation); dietary exposure to pesticide deltamethrin (DM) from E0 to P22 (3 mg/kg every 3 days)
Allele Type: ASD mutation
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Mark J. Zylka Lab (PMID 33023670)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Rearing behavior | Decreased | Open field test | week 52 | Jiménez JA et al. (2022) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | week 52 | Jiménez JA et al. (2022) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cardiovascular development and function | No change | Immunostaining | week 52 | Jiménez JA et al. (2022) |
Social behavior | Social memory | Increased | Three-chamber social approach test | week 26 | Jiménez JA et al. (2022) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | week 52 | Jiménez JA et al. (2022) |
Social behavior | Social approach | No change | Three-chamber social approach test | week 52 | Jiménez JA et al. (2022) |
Social behavior | Social approach | Increased | Three-chamber social approach test | week 26 | Jiménez JA et al. (2022) |
Developmental profile | Tissue weight | Increased | Measurement of placental weight | E15 | Jiménez JA et al. (2022) |
Developmental profile | Size/growth | Increased | Body weight measurement | E15 | Jiménez JA et al. (2022) |
Emotion | Anxiety | No change | Open field test | week 52 | Jiménez JA et al. (2022) |
Emotion | Anxiety | Increased | Elevated plus maze test | week 26, week 52 | Jiménez JA et al. (2022) |
Molecular profile | Gene expression | Decreased | RNA sequencing | E15, week 52 | Jiménez JA et al. (2022) |
Molecular profile | Differential gene expression | Abnormal | RNA sequencing | E15, week 52 | Jiménez JA et al. (2022) |
M_CHD8_2_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Targeted deletion of exons 11-13 of the Chd8 gene.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6J
Es cell line: Not specified
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Communications | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Developmental profile | Size/growth | Decreased | General observations | E8.5-e12.5 | Katayama Y , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
M_CHD8_2_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Targeted deletion of exons 11-13 of the Chd8 gene.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6J
Es cell line: Not specified
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Measurement of tissue weight | E14.5 | Katayama Y , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | E18.5; 9 weeks | Katayama Y , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Cranial computerized tomography (ct) scan | E18.5; 9 weeks | Katayama Y , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Repetitive behavior | Perseveration | Increased | T-maze test | 44-48 weeks | Katayama Y , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Physiological parameters | Digestive system function: gastrointestinal motility | No change | Measurement of gi motility | 9 weeks | Katayama Y , et al. (2016) |
Communications | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Developmental profile | Size/growth | No change | General observations | E8.5-e12.5 | Katayama Y , et al. (2016) |
Developmental profile | Digestive system development | Decreased | General observations | 9 weeks | Katayama Y , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Learning & memory | Spatial reference memory | No change | T-maze test | 44-48 weeks | Katayama Y , et al. (2016) |
Learning & memory | Spatial learning | No change | Barnes maze test | 17-21 weeks | Katayama Y , et al. (2016) |
Learning & memory | Reward reinforced choice behavior | No change | T-maze test | 44-48 weeks | Katayama Y , et al. (2016) |
Learning & memory | Cognitive flexibility | No change | Barnes maze test | 17-21 weeks | Katayama Y , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | No change | Western blot | E18.5 and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | No change | Quantitative pcr (qrt-pcr) | E18.5 and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | Increased | Quantitative pcr (qrt-pcr) | E10.5, e14.5, and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | Decreased | Western blot | E10.5, e14.5, e18.5, and 9 weeks | Katayama Y , et al. (2016) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | E10.5, e14.5, e18.5, and 9 weeks | Katayama Y , et al. (2016) |
M_CHD8_3_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous; mixed
Mutation:
Targeted deletion of all the exons of the Chd8 gene or Targeted deletion of exons 11-13 of the Chd8 gene.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6J or C57BL/6
Es cell line: Not specified
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 12-50 weeks | Katayama Y , et al. (2016) |
Motor phenotype | Grip strength | No change | Wire hang test | 12-50 weeks | Katayama Y , et al. (2016) |
Motor phenotype | General locomotor activity | No change | Open field test | 2-16 weeks | Katayama Y , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Sensory | Startle response: acoustic stimulus | Decreased | Acoustic startle reflex test | 16-19 weeks | Katayama Y , et al. (2016) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | 16-19 weeks | Katayama Y , et al. (2016) |
Sensory | Sensorimotor gating | Decreased | Prepulse inhibition | 16-19 weeks | Katayama Y , et al. (2016) |
Sensory | Pain or nociception | No change | Hot plate test | 13-16 weeks | Katayama Y , et al. (2016) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 14-19 weeks | Katayama Y , et al. (2016) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 47-50 weeks | Katayama Y , et al. (2016) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 3-17 weeks | Katayama Y , et al. (2016) |
Social behavior | Social approach | No change | Three-chamber social approach test | 14-19 weeks | Katayama Y , et al. (2016) |
Social behavior | Nest building behavior | No change | Nest building assay | 17-20 weeks | Katayama Y , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Physiological parameters | Core body temperature | No change | Body temperature measurement | Unreported | Katayama Y , et al. (2016) |
Communications | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Emotion | Depression | No change | Forced swim test | 16-20 weeks | Katayama Y , et al. (2016) |
Emotion | Anxiety | Increased | Light-dark exploration test | 12-16 weeks | Katayama Y , et al. (2016) |
Emotion | Anxiety | Increased | Open field test | 12-16 weeks | Katayama Y , et al. (2016) |
Emotion | Anxiety | Increased | Elevated plus maze test | 12-16 weeks | Katayama Y , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Katayama Y , et al. (2016) |
M_CHD8_4_KD
Model Type: Genetic
Model Genotype: Wild type
Mutation:
Chd8 was knocked down using shRNAs, via in utero electroporation of the DNA mixture containing shRNAs aginst Chd8 (Sigma; Clone ID: NM_201637.1-1439s1c1 or Clone ID: NM_201637.2-3342s21c1) along with indicators (pCAGIG-Venus and membrane bound-GFP) at E13 embryos.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: Swiss Webster
Es cell line: Not specified
Model Source: Taconic Biosciences
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Increased | NA | E16 | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Decreased | Immunostaining | E16 | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Abnormal | Confocal microscopy | E13-e16 | Durak O , et al. (2016) |
Neurophysiology | Apoptosis: brain cells | No change | Immunostaining | E16 | Durak O , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Communications | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Decreased | Luciferase reporter assay | E15 | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Decreased | Western blot | E15 | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Decreased | Rna sequencing | E15 | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Decreased | Quantitative pcr (qrt-pcr) | E15 | Durak O , et al. (2016) |
Molecular profile | Gene expression | Decreased | Rna sequencing | E15 | Durak O , et al. (2016) |
Molecular profile | Gene expression | Decreased | Western blot | E15 | Durak O , et al. (2016) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | E15 | Durak O , et al. (2016) |
M_CHD8_4_KD_CTNNB1
Model Type: RESCUE-Genetic
Model Genotype: Wild type
Mutation:
Rescue of phenotypes associated with Chd8 KD was attempted by expressing stablized Ctnnb1, to enhance Wnt signaling. Chd8 was knocked down using shRNAs, via in utero electroporation of the DNA mixture containing shRNAs aginst Chd8 (Sigma; Clone ID: NM_201637.1-1439s1c1 or Clone ID: NM_201637.2-3342s21c1) and the stablized form (S37A) of Ctnnb1 construct along with indicators (pCAGIG-Venus and membrane bound-GFP) at E13 embryos.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: Swiss Webster
Es cell line: Not specified
Model Source: Taconic Biosciences
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Restored | NA | E16 | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Restored | Immunostaining | E16 | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Restored | Confocal microscopy | E13-e16 | Durak O , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Communications | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Restored | Luciferase reporter assay | E15 | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Restored | Western blot | E15 | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Restored | Rna sequencing | E15 | Durak O , et al. (2016) |
Molecular profile | Signaling: wnt pathway | Restored | Quantitative pcr (qrt-pcr) | E15 | Durak O , et al. (2016) |
Molecular profile | Gene expression | Restored | Rna sequencing | E15 | Durak O , et al. (2016) |
Molecular profile | Gene expression | Restored | Western blot | E15 | Durak O , et al. (2016) |
Molecular profile | Gene expression | Restored | Quantitative pcr (qrt-pcr) | E15 | Durak O , et al. (2016) |
M_CHD8_4_KD_HCHD8
Model Type: RESCUE-Genetic
Model Genotype: Wild type
Mutation:
Human Chd8 was used to rescue Chd8 KD in mice. Chd8 was knocked down using shRNAs, via in utero electroporation of the DNA mixture containing shRNAs aginst Chd8 (Sigma; Clone ID: NM_201637.1-1439s1c1 or Clone ID: NM_201637.2-3342s21c1) and the full-length human CHD8 construct along with indicators (pCAGIG-Venus and membrane bound-GFP) at E13 embryos.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: Swiss Webster
Es cell line: Not specified
Model Source: Taconic Biosciences
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Restored | NA | E16 | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Restored | Immunostaining | E16 | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Restored | Confocal microscopy | E13-e16 | Durak O , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Communications | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
M_CHD8_5_KD
Model Type: Genetic
Model Genotype: Wild type
Mutation:
Chd8 was knocked down using shRNAs, via in utero electroporation of the DNA mixture containing shRNAs aginst Chd8 (Sigma; Clone ID: NM_201637.1-1439s1c1 or Clone ID: NM_201637.2-3342s21c1) along with indicators (pCAGIG-Venus and membrane bound-GFP) at E15 embryos.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: Swiss Webster
Es cell line: Not specified
Model Source: Taconic Biosciences
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Motor phenotype | General locomotor activity | No change | Open field test | 10-13 weeks | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Decreased | Sholl analysis | 5 months | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Sholl analysis | 5 months | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Abnormal | Confocal microscopy | 3 months | Durak O , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 13-16 weeks | Durak O , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Communications | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Emotion | Anxiety | Increased | Light-dark exploration test | 11-18 weeks | Durak O , et al. (2016) |
Emotion | Anxiety | Increased | Elevated plus maze test | 11-18 weeks | Durak O , et al. (2016) |
Emotion | Anxiety | No change | Open field test | 10-13 weeks | Durak O , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Learning & memory | Cued or contextual fear conditioning: context discrimination | No change | Fear conditioning test | 16-19 weeks | Durak O , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
M_CHD8_5_KD_CTNNB1
Model Type: RESCUE-Genetic
Model Genotype: Wild type
Mutation:
Rescue of phenotypes associated with Chd8 KD was attempted by expressing stablized Ctnnb1, to enhance Wnt signaling. Chd8 was knocked down using shRNAs, via in utero electroporation of the DNA mixture containing shRNAs aginst Chd8 (Sigma; Clone ID: NM_201637.1-1439s1c1 or Clone ID: NM_201637.2-3342s21c1) and the stablized form (S37A) of Ctnnb1 construct along with indicators (pCAGIG-Venus and membrane bound-GFP) at E15 embryos.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: Swiss Webster
Es cell line: Not specified
Model Source: Taconic Biosciences
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Motor phenotype | General locomotor activity | No adverse effect | Open field test | 10-13 weeks | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Ameliorated | Sholl analysis | 5 months | Durak O , et al. (2016) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Restored | Sholl analysis | 5 months | Durak O , et al. (2016) |
Neurophysiology | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 13-16 weeks | Durak O , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Communications | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Emotion | Anxiety | Restored | Light-dark exploration test | 11-18 weeks | Durak O , et al. (2016) |
Emotion | Anxiety | Restored | Elevated plus maze test | 11-18 weeks | Durak O , et al. (2016) |
Emotion | Anxiety | No adverse effect | Open field test | 10-13 weeks | Durak O , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Durak O , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Durak O , et al. (2016) |
M_CHD8_6_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Mouse model with a Cas9 mediated heterozygous germline frameshift deletion of 7 nucleotides in exon 1.
Allele Type: Knockout
Strain of Origin: C57BL/6
Genetic Background: -
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 10 weeks | Platt RJ , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Decreased | Three-chamber social approach test | 10 weeks | Platt RJ , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Decreased | Open field test | 10 weeks | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Somatosensory cortical map architecture | No change | Immunohistochemistry | E15.5 | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal specification | No change | NA | E15.5 | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | No change | Immunohistochemistry | E15.5 | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical lamination | No change | Immunohistochemistry | E15.5 | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | No change | Immunohistochemistry | E15.5 | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | 10 weeks | Platt RJ , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Abnormal | Rna sequencing | 10 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | Increased | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | Increased | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | No change | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | No change | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | Decreased | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | 6-8 weeks | Platt RJ , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | No change | Grooming behavior assessments | 10 weeks | Platt RJ , et al. (2017) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 10 weeks | Platt RJ , et al. (2017) |
Repetitive behavior | Perseveration | Increased | Accelerating rotarod test | 10-14 weeks | Platt RJ , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 10 weeks | Platt RJ , et al. (2017) |
Social behavior | Social approach | No change | Three-chamber social approach test | 10 weeks | Platt RJ , et al. (2017) |
Social behavior | Juvenile play | Increased | Reciprocal social interaction test | 3.3-3.6weeks | Platt RJ , et al. (2017) |
Physiological parameters | Reproductive function | No change | General observations | Adult | Platt RJ , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Communications | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Developmental profile | Skeletal development: craniofacial | Increased | Cranial measurements | 10 weeks | Platt RJ , et al. (2017) |
Developmental profile | Size/growth | Decreased | Body weight measurement | 10 weeks | Platt RJ , et al. (2017) |
Developmental profile | Mortality/lethality | No change | Survival analysis | P0 | Platt RJ , et al. (2017) |
Emotion | Exploratory activity: habituation | No change | Three-chamber social approach test | 10 weeks | Platt RJ , et al. (2017) |
Emotion | Anxiety | Increased | Open field test | 10-14 weeks | Platt RJ , et al. (2017) |
Emotion | Anxiety | Increased | Light-dark exploration test | 10-14 weeks | Platt RJ , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | No change | Fear conditioning test | 10 weeks | Platt RJ , et al. (2017) |
Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 10 weeks | Platt RJ , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Molecular profile | Targeted expression | Decreased | Western blot | 10 weeks | Platt RJ , et al. (2017) |
Molecular profile | Targeted expression | Decreased | Immunohistochemistry | 10 weeks | Platt RJ , et al. (2017) |
Molecular profile | Signaling: wnt pathway | Increased | Rna sequencing | 10 weeks | Platt RJ , et al. (2017) |
Molecular profile | Protein-dna complex assembly | No change | Chromatin immunoprecipitation sequencing (chip-seq) | 10 weeks | Platt RJ , et al. (2017) |
Molecular profile | Gene expression | Abnormal | Rna sequencing | 10 weeks | Platt RJ , et al. (2017) |
Molecular profile | Chromatin modification | Abnormal | Rna sequencing | 10 weeks | Platt RJ , et al. (2017) |
Molecular profile | Cell adhesion | Abnormal | Rna sequencing | 10 weeks | Platt RJ , et al. (2017) |
M_CHD8_7_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mouse model with a Cas9 mediated homozygous germline frameshift deletion of 7 nucleotides in exon 1.
Allele Type: Knockout
Strain of Origin: C57BL/6
Genetic Background: -
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Communications | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Developmental profile | Mortality/lethality | Increased | Survival analysis | P0 | Platt RJ , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
M_CHD8_8_CKO_MIXED_NAC
Model Type: Genetic
Model Genotype: Other
Mutation:
Conditional ablation of Chd8 in nucleus accumbens using AAV vectors containing targeting sgRNA (CRISPR) injected into the Nac, leading to cells with monoallelic and biallelic mutations in Chd8
Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: -
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Three-chamber social approach test | Adult | Platt RJ , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | Adult | Platt RJ , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Repetitive behavior | Perseveration | Increased | Accelerating rotarod test | Adult | Platt RJ , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Communications | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Emotion | Anxiety | No change | Open field test | Adult | Platt RJ , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
M_CHD8_9_CKO_MIXED_DS
Model Type: Genetic
Model Genotype: Other
Mutation:
Conditional ablation of Chd8 in dorsal striatum using AAV vectors containing targeting sgRNA (CRISPR) injected into the DS, leading to cells with monoallelic and biallelic mutations in Chd8
Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: -
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | Adult | Platt RJ , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Communications | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Emotion | Anxiety | No change | Open field test | Adult | Platt RJ , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Learning & memory | Procedural learning | No change | Accelerating rotarod test | Adult | Platt RJ , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Platt RJ , et al. (2017) |
Other CHD8 Rescue Models(8 Models)
M_CHD8_1_KO_HT | 1 | Genetic | Pharmaceutical | Oxytocin |
M_CHD8_4_KD | 1 | Genetic | Genetic | stablized Ctnnb1(S37A) |
M_CHD8_4_KD | 1 | Genetic | Genetic | human CHD8 |
M_CHD8_5_KD | 1 | Genetic | Genetic | stablized Ctnnb1(S37A) |
M_CHD8_12_CKO_HM | 1 | Genetic | Pharmaceutical | CPI-455 |
M_CHD8_27_KO_HT | 1 | Genetic | Dietary | Bacteroides uniformis |
M_CHD8_27_KO_HT | 1 | Genetic | Behavioral | Cohousing |
M_CHD8_27_KO_HT | 1 | Genetic | Pharmaceutical | S-benzyl-L-cysteine |
CNVs associated with CHD8(1 Models)
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14q11.2 | 51 | Deletion-Duplication | 67 / 372 |