Genetic Animal Models / CNTNAP2

CNTNAP2 contactin associated protein-like 2

Model Species
Mus musculus
Gene Aliases
5430425M22Rik, Caspr2, mKIAA0868
Reports
11
Associated Human Genes
CNTNAP2
Models / Rescue Models
28 / 15
Rescue Model
-
Model Summary

Axon-glia interactions mediated by Cntnap2 and Tag-1 s allow myelinating glial cells to organize ion channels in the underlying axonal membrane.

Reports related to CNTNAP2 (11 Reports)
# Type Title Author, Year
1 Primary Juxtaparanodal clustering of Shaker-like K channels in myelinated axons depends on Caspr2 and TAG-1. Poliak S , et al. (2003)
2 Additional Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B. Horresh I , et al. (2010)
3 Additional Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Peagarikano O , et al. (2011)
4 Additional Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Peagarikano O , et al. (2015)
5 Additional Cerebellar associative sensory learning defects in five mouse autism models. Kloth AD , et al. (2015)
6 Additional Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder. Brunner D , et al. (2015)
7 Additional Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology. Thomas AM , et al. (2016)
8 Additional Sex-specific gene-environment interactions underlying ASD-like behaviors. Schaafsma SM , et al. (2017)
9 Additional Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice. Selimbeyoglu A , et al. (2017)
10 Additional CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Gao R , et al. (2018)
11 Additional Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models. Antoine MW , et al. (2019)
Show all Construct Details Show all Phenotypic Profiles

M_CNTNAP2_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * ICR

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Poliak S , et al. (2003)
Motor phenotype Ataxia No Change General observations 20 months Poliak S , et al. (2003)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No Change Electron microscopy Adult Poliak S , et al. (2003)
Neurophysiology - Not Reported - - Poliak S , et al. (2003)
Repetitive behavior - Not Reported - - Poliak S , et al. (2003)
Seizure - Not Reported - - Poliak S , et al. (2003)
Sensory - Not Reported - - Poliak S , et al. (2003)
Social behavior - Not Reported - - Poliak S , et al. (2003)
Communications - Not Reported - - Poliak S , et al. (2003)
Developmental profile Size/growth Decreased General observations P0 Poliak S , et al. (2003)
Emotion - Not Reported - - Poliak S , et al. (2003)
Homeostasis - Not Reported - - Poliak S , et al. (2003)
Immune response - Not Reported - - Poliak S , et al. (2003)
Learning & memory - Not Reported - - Poliak S , et al. (2003)
Maternal behavior - Not Reported - - Poliak S , et al. (2003)
Molecular profile Protein localization: synapse Decreased Immunohistochemistry: fluorescence Adult Poliak S , et al. (2003)

M_CNTNAP2_2_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene (Reference: PMID 12963709).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: BALB/c * C57BL/6 * 129S1/Sv * 129X1/SvJ * ICR

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Horresh I , et al. (2010)
Motor phenotype - Not Reported - - Horresh I , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Horresh I , et al. (2010)
Neurophysiology - Not Reported - - Horresh I , et al. (2010)
Repetitive behavior - Not Reported - - Horresh I , et al. (2010)
Seizure - Not Reported - - Horresh I , et al. (2010)
Sensory - Not Reported - - Horresh I , et al. (2010)
Social behavior - Not Reported - - Horresh I , et al. (2010)
Communications - Not Reported - - Horresh I , et al. (2010)
Developmental profile - Not Reported - - Horresh I , et al. (2010)
Emotion - Not Reported - - Horresh I , et al. (2010)
Homeostasis - Not Reported - - Horresh I , et al. (2010)
Immune response - Not Reported - - Horresh I , et al. (2010)
Learning & memory - Not Reported - - Horresh I , et al. (2010)
Maternal behavior - Not Reported - - Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Abnormal Immunohistochemistry: fluorescence Unreported Horresh I , et al. (2010)

M_CNTNAP2_2_KO_HM_hCNTNAP2

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Transgene of HA-tagged construct of human Cntnap2 cDNA, C2FL (full-length), in Cntnap2 knockout mice (PMID 112963709).

Allele Type: Knockout
Strain of Origin: CB6F1 (Transgene); (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: BALB/c * C57BL/6 * 129S1/Sv * 129X1/SvJ * ICR

Es cell line: -
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Horresh I , et al. (2010)
Motor phenotype - Not Reported - - Horresh I , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Horresh I , et al. (2010)
Neurophysiology - Not Reported - - Horresh I , et al. (2010)
Repetitive behavior - Not Reported - - Horresh I , et al. (2010)
Seizure - Not Reported - - Horresh I , et al. (2010)
Sensory - Not Reported - - Horresh I , et al. (2010)
Social behavior - Not Reported - - Horresh I , et al. (2010)
Communications - Not Reported - - Horresh I , et al. (2010)
Developmental profile - Not Reported - - Horresh I , et al. (2010)
Emotion - Not Reported - - Horresh I , et al. (2010)
Homeostasis - Not Reported - - Horresh I , et al. (2010)
Immune response - Not Reported - - Horresh I , et al. (2010)
Learning & memory - Not Reported - - Horresh I , et al. (2010)
Maternal behavior - Not Reported - - Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Restored Immunohistochemistry: fluorescence Unreported Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Restored Immunohistochemistry: fluorescence Unreported Horresh I , et al. (2010)

M_CNTNAP2_3_KO_HM_hCNTNAP2d4.1

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Transgene of HA-tagged construct of human Cntnap2 cDNA with 4.1B binding domain deletion, C2d4.1 (delection of amino acids R1298 to H1304), in Cntnap2 knockout mice (PMID 12963709).

Allele Type: Humanized LOF mutation
Strain of Origin: CB6F1 (Transgene); (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: BALB/c * C57BL/6 * 129S1/Sv * 129X1/SvJ * ICR

Es cell line: -
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Horresh I , et al. (2010)
Motor phenotype - Not Reported - - Horresh I , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Horresh I , et al. (2010)
Neurophysiology - Not Reported - - Horresh I , et al. (2010)
Repetitive behavior - Not Reported - - Horresh I , et al. (2010)
Seizure - Not Reported - - Horresh I , et al. (2010)
Sensory - Not Reported - - Horresh I , et al. (2010)
Social behavior - Not Reported - - Horresh I , et al. (2010)
Communications - Not Reported - - Horresh I , et al. (2010)
Developmental profile - Not Reported - - Horresh I , et al. (2010)
Emotion - Not Reported - - Horresh I , et al. (2010)
Homeostasis - Not Reported - - Horresh I , et al. (2010)
Immune response - Not Reported - - Horresh I , et al. (2010)
Learning & memory - Not Reported - - Horresh I , et al. (2010)
Maternal behavior - Not Reported - - Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry: fluorescence Unreported Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry: fluorescence Unreported Horresh I , et al. (2010)

M_CNTNAP2_5_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene. In Gao et al. 2018 (PMID 29610457) Cntnap2 null mutant mice were crossed with heterozygous transgenic mice carrying the interneuron-specific Gad1-eGFP reporter to generate Cntnap2 null mutant (test animals) and wildtype (controls) mice with the reporter.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Core body temperature No Change Body temperature measurement 4, 8 months Thomas AM , et al. (2016)
Physiological parameters Core body temperature No Change Body weight measurement P4, P7, P15 Brunner D , et al. (2015)
Circadian sleep/wake cycle - Not Reported - - -
Circadian sleep/wake cycle - Not Reported - - Antoine MW , et al. (2019)
Circadian sleep/wake cycle - Not Reported - - Gao R , et al. (2018)
Circadian sleep/wake cycle - Not Reported - - Selimbeyoglu A , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - Schaafsma SM , et al. (2017)
Circadian sleep/wake cycle Sleep pattern Abnormal Electroencephalogram (EEG) 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Rapid Eye Movement Sleep (REMS) Decreased Electroencephalogram (EEG) 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle No Change Electromyogram (EMG): home cage 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Circadian rhythms: timing/phases of locomotor activity Abnormal Electromyogram (EMG): home cage 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Circadian rhythms: timing/phases of locomotor activity Abnormal Body temperature measurement 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle - Not Reported - - Brunner D , et al. (2015)
Circadian sleep/wake cycle - Not Reported - - Kloth AD , et al. (2015)
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2011)
Motor phenotype - Not Reported - - -
Motor phenotype - Not Reported - - Antoine MW , et al. (2019)
Motor phenotype - Not Reported - - Gao R , et al. (2018)
Motor phenotype Spontaneous Movement Increased Open field test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Increased Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Increased Open field test P40 Schaafsma SM , et al. (2017)
Motor phenotype - Not Reported - - Thomas AM , et al. (2016)
Motor phenotype Righting response Decreased Righting reflex test P4, P7 Brunner D , et al. (2015)
Motor phenotype Righting response Decreased Negative geotaxis test P4, P7 Brunner D , et al. (2015)
Motor phenotype Negative Geotaxis No Change Negative geotaxis test P4, P7, P15 Brunner D , et al. (2015)
Motor phenotype Jerky Movement Increased Observation of repetitive behavior: Smartcube analysis 3 months Brunner D , et al. (2015)
Motor phenotype General locomotor activity Increased Home cage behavior 3 months Brunner D , et al. (2015)
Motor phenotype Gait Decreased Footprint analysis 1 month, 2 months Brunner D , et al. (2015)
Motor phenotype Gait Decreased Running stride analysis 1 month, 2 months Brunner D , et al. (2015)
Motor phenotype Gait No Change Running stride analysis 2-4 months Kloth AD , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype Motor coordination and balance Increased Accelerating rotarod test Unreported Peagarikano O , et al. (2011)
Motor phenotype General locomotor activity Increased Open field test Unreported Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - -
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Antoine MW , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity No Change Sholl analysis: Golgi-Cox staining 6 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis: Golgi-Cox staining 5 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length No Change Golgi-Cox staining 6 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Golgi-Cox staining 5 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Selimbeyoglu A , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schaafsma SM , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Thomas AM , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Brunner D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Purkinje cells No Change Histology: Histology 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No Change Sholl analysis: Golgi-Cox staining 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity No Change Sholl analysis: Golgi-Cox staining 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: molecular layer thickness No Change Histology: Histology 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: granule cell layer thickness No Change Histology: Histology 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Oxytocin expressing Decreased Immunohistochemistry: stereology 4 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Oxytocin expressing No Change Immunohistochemistry: stereology P7 Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number in the brain No Change Stereology 4 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number in the brain No Change Immunohistochemistry: stereology 4 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Interneurons Decreased Immunohistochemistry: fluorescence P14 Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal migration Abnormal Immunohistochemistry P14 Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Abnormal Immunohistochemistry Unreported Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No Change Histology: Histology 6 months Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Abnormal Immunohistochemistry: BrDu P7 Peagarikano O , et al. (2011)
Neurophysiology Action potential firing No Change Whole-cell voltage clamp P42-P92 -
Neurophysiology Synaptic plasticity Decreased Whole-cell current clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology - Not Reported - - Gao R , et al. (2018)
Neurophysiology Neuronal activation: novel object interaction Increased Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation: non-familiar social interaction Increased Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation: locomotion No Change Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation: familiar social interaction Increased Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation Abnormal Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology - Not Reported - - Schaafsma SM , et al. (2017)
Neurophysiology - Not Reported - - Thomas AM , et al. (2016)
Neurophysiology - Not Reported - - Brunner D , et al. (2015)
Neurophysiology - Not Reported - - Kloth AD , et al. (2015)
Neurophysiology Neurotransmitter release: neurohypophysial Decreased Radioimmunoassay (RIA) 4 weeks Peagarikano O , et al. (2015)
Neurophysiology Network excitability Decreased Calcium imaging 2-4 months Peagarikano O , et al. (2011)
Neurophysiology Action potential properties: amplitude, rate of depolarization and repolarization No Change Calcium imaging 2-4 months Peagarikano O , et al. (2011)
Repetitive behavior - Not Reported - - -
Repetitive behavior - Not Reported - - Antoine MW , et al. (2019)
Repetitive behavior - Not Reported - - Gao R , et al. (2018)
Repetitive behavior - Not Reported - - Selimbeyoglu A , et al. (2017)
Repetitive behavior - Not Reported - - Schaafsma SM , et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments: novel cage 8 weeks Thomas AM , et al. (2016)
Repetitive behavior - Not Reported - - Brunner D , et al. (2015)
Repetitive behavior - Not Reported - - Kloth AD , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior Self grooming: perseveration Increased General observations Unreported Peagarikano O , et al. (2011)
Repetitive behavior Perseveration Increased T-maze test: spontaneous alternation Unreported Peagarikano O , et al. (2011)
Seizure - Not Reported - - -
Seizure - Not Reported - - Antoine MW , et al. (2019)
Seizure - Not Reported - - Gao R , et al. (2018)
Seizure - Not Reported - - Selimbeyoglu A , et al. (2017)
Seizure - Not Reported - - Schaafsma SM , et al. (2017)
Seizure Seizures No Change Electroencephalogram (EEG) 4, 8 months Thomas AM , et al. (2016)
Seizure Absence seizures Increased Electroencephalogram (EEG) 4, 8 months Thomas AM , et al. (2016)
Seizure - Not Reported - - Brunner D , et al. (2015)
Seizure - Not Reported - - Kloth AD , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Seizure Seizures Increased General observations 6 months Peagarikano O , et al. (2011)
Seizure Seizures Abnormal Electroencephalogram (EEG) 6 months Peagarikano O , et al. (2011)
Sensory - Not Reported - - -
Sensory - Not Reported - - Antoine MW , et al. (2019)
Sensory - Not Reported - - Gao R , et al. (2018)
Sensory - Not Reported - - Selimbeyoglu A , et al. (2017)
Sensory - Not Reported - - Schaafsma SM , et al. (2017)
Sensory - Not Reported - - Thomas AM , et al. (2016)
Sensory Startle response: acoustic stimulus No Change Acoustic startle reflex test 2 months Brunner D , et al. (2015)
Sensory Sensorimotor gating Increased Prepulse inhibition 2 months Brunner D , et al. (2015)
Sensory - Not Reported - - Kloth AD , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Sensory Startle response: acoustic stimulus No Change Acoustic startle reflex test: white noise stimulus Unreported Peagarikano O , et al. (2011)
Sensory Pain or nociception Increased Hot plate test Unreported Peagarikano O , et al. (2011)
Sensory Olfaction Increased Buried food test Unreported Peagarikano O , et al. (2011)
Social behavior - Not Reported - - -
Social behavior - Not Reported - - Antoine MW , et al. (2019)
Social behavior - Not Reported - - Gao R , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Social behavior Inanimate object preference Increased Novel object recognition test Adult Selimbeyoglu A , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social habituation No Change Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social dishabituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social interaction Decreased Reciprocal social interaction test 7 weeks Thomas AM , et al. (2016)
Social behavior Social memory No Change Three-chamber social approach test: preference for recognition of a social stimulus 2 months Brunner D , et al. (2015)
Social behavior Social interaction No Change Reciprocal social interaction test 6.4-7.4 weeks Brunner D , et al. (2015)
Social behavior Social interaction No Change Three-chamber social approach test: preference for a social stimulus versus a non-social stimulus 2 months Brunner D , et al. (2015)
Social behavior Mating behavior Decreased Scent marking test 2 months Brunner D , et al. (2015)
Social behavior Mating behavior No Change Scent marking test: exposure to female urine 2 months Brunner D , et al. (2015)
Social behavior - Not Reported - - Kloth AD , et al. (2015)
Social behavior Social interaction Decreased Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social interaction Decreased Three-chamber social approach test Unreported Peagarikano O , et al. (2011)
Social behavior Nest building behavior Decreased General observations Unreported Peagarikano O , et al. (2011)
Social behavior Juvenile play Decreased Reciprocal social interaction test: juvenile play P21 Peagarikano O , et al. (2011)
Communications - Not Reported - - -
Communications - Not Reported - - Antoine MW , et al. (2019)
Communications - Not Reported - - Gao R , et al. (2018)
Communications - Not Reported - - Selimbeyoglu A , et al. (2017)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P3 Schaafsma SM , et al. (2017)
Communications - Not Reported - - Thomas AM , et al. (2016)
Communications Ultrasonic vocalization: Isolation induced No Change Monitoring ultrasonic vocalizations: maternal isolation induced neonatal ultrasonic vocalizations, pivoting P4, P7, P15 Brunner D , et al. (2015)
Communications Ultrasonic vocalization: Interaction induced: opposite sex stimulus Decreased Scent marking test: exposure to female urine Adult Brunner D , et al. (2015)
Communications - Not Reported - - Kloth AD , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations: maternal separation P3-P12 Peagarikano O , et al. (2011)
Developmental profile - Not Reported - - -
Developmental profile - Not Reported - - Antoine MW , et al. (2019)
Developmental profile - Not Reported - - Gao R , et al. (2018)
Developmental profile - Not Reported - - Selimbeyoglu A , et al. (2017)
Developmental profile - Not Reported - - Schaafsma SM , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 7-13 weeks Thomas AM , et al. (2016)
Developmental profile Size/growth Decreased General observations P4, P7, P15, 1 month, 2 months, 2.7 months, 3 months Brunner D , et al. (2015)
Developmental profile Developmental trajectory Increased Developmental milestone measurements: rolling to the side P4 Brunner D , et al. (2015)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements: eye opening P13 Brunner D , et al. (2015)
Developmental profile Developmental trajectory Increased Negative geotaxis test: walk downs P15 Brunner D , et al. (2015)
Developmental profile - Not Reported - - Kloth AD , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile Size/growth No Change General observations Unreported Peagarikano O , et al. (2011)
Developmental profile General characteristics No Change General observations Unreported Peagarikano O , et al. (2011)
Emotion - Not Reported - - -
Emotion - Not Reported - - Antoine MW , et al. (2019)
Emotion - Not Reported - - Gao R , et al. (2018)
Emotion - Not Reported - - Selimbeyoglu A , et al. (2017)
Emotion Anxiety Decreased Open field test P40 Schaafsma SM , et al. (2017)
Emotion Exploratory activity Increased Open field test 8-9 weeks Thomas AM , et al. (2016)
Emotion Exploratory activity Decreased Three-chamber social approach test: exploration of side chambers during habituation phase, time spent in side chambers during sociability phase, time spent sniffing of stimulus cups during sociability phase 2 months Brunner D , et al. (2015)
Emotion Anxiety No Change Marble-burying test 2 months Brunner D , et al. (2015)
Emotion - Not Reported - - Kloth AD , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Emotion Anxiety No Change Light-dark exploration test: Light-dark exploration test Unreported Peagarikano O , et al. (2011)
Homeostasis - Not Reported - - -
Homeostasis - Not Reported - - Antoine MW , et al. (2019)
Homeostasis - Not Reported - - Gao R , et al. (2018)
Homeostasis - Not Reported - - Selimbeyoglu A , et al. (2017)
Homeostasis - Not Reported - - Schaafsma SM , et al. (2017)
Homeostasis - Not Reported - - Thomas AM , et al. (2016)
Homeostasis - Not Reported - - Brunner D , et al. (2015)
Homeostasis - Not Reported - - Kloth AD , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2011)
Immune response - Not Reported - - -
Immune response - Not Reported - - Antoine MW , et al. (2019)
Immune response - Not Reported - - Gao R , et al. (2018)
Immune response - Not Reported - - Selimbeyoglu A , et al. (2017)
Immune response - Not Reported - - Schaafsma SM , et al. (2017)
Immune response - Not Reported - - Thomas AM , et al. (2016)
Immune response - Not Reported - - Brunner D , et al. (2015)
Immune response - Not Reported - - Kloth AD , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Immune response Astrogliosis Increased Western blot 6 months Peagarikano O , et al. (2011)
Learning & memory - Not Reported - - -
Learning & memory - Not Reported - - Antoine MW , et al. (2019)
Learning & memory - Not Reported - - Gao R , et al. (2018)
Learning & memory - Not Reported - - Selimbeyoglu A , et al. (2017)
Learning & memory - Not Reported - - Schaafsma SM , et al. (2017)
Learning & memory - Not Reported - - Thomas AM , et al. (2016)
Learning & memory Spatial working memory Increased Water T-maze test: acquisition phase 2 months Brunner D , et al. (2015)
Learning & memory Cognitive flexibility No Change Water T-maze test: reversal phase 2 months Brunner D , et al. (2015)
Learning & memory Spatial learning No Change Water Y-maze test: Water Y-maze test 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning: extinction and reactivation No Change Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning No Change Eyeblink conditioning: response amplitude 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning Decreased Eyeblink conditioning: probability of generating a response 2-4 months Kloth AD , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory Spatial learning No Change Morris water maze test Unreported Peagarikano O , et al. (2011)
Learning & memory Object recognition memory No Change General observations Unreported Peagarikano O , et al. (2011)
Learning & memory Cognitive flexibility Decreased Morris water maze test Unreported Peagarikano O , et al. (2011)
Maternal behavior - Not Reported - - -
Maternal behavior - Not Reported - - Antoine MW , et al. (2019)
Maternal behavior - Not Reported - - Gao R , et al. (2018)
Maternal behavior - Not Reported - - Selimbeyoglu A , et al. (2017)
Maternal behavior - Not Reported - - Schaafsma SM , et al. (2017)
Maternal behavior - Not Reported - - Thomas AM , et al. (2016)
Maternal behavior Maternal nurturing No Change General observations: milk content P4, P7 Brunner D , et al. (2015)
Maternal behavior - Not Reported - - Kloth AD , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2011)
Molecular profile - Not Reported - - -
Molecular profile - Not Reported - - Antoine MW , et al. (2019)
Molecular profile Targeted expression Decreased Western blot 5 months Gao R , et al. (2018)
Molecular profile Protein localization: membrane Decreased Western blot: fractionation 5 months Gao R , et al. (2018)
Molecular profile Protein expression level evidence No Change Western blot 5 months Gao R , et al. (2018)
Molecular profile - Not Reported - - Selimbeyoglu A , et al. (2017)
Molecular profile Chromatin modification Decreased Quantitative PCR (qRT-PCR): chromatin immunoprecipitation (ChIP) P40 Schaafsma SM , et al. (2017)
Molecular profile - Not Reported - - Thomas AM , et al. (2016)
Molecular profile - Not Reported - - Brunner D , et al. (2015)
Molecular profile - Not Reported - - Kloth AD , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2011)

M_CNTNAP2_5_KO_HM_AVP-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of arginine vasopressin, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test 6-8 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_AVP-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered arginine vasopressin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_AVP-OXTR-Ant

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered with oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by AVP at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_AVPR-Ant_AVP

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered arginine vasopressin receptor (AVP-V1a receptor)antagonist (reclovaptan) intranasally at a dose of 300ug/kg, followed by AVP at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_DREADD-OXTN

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Using the Designer Receptor Exclusively Activated by Designer Drug(s) (DREADD) approach a modified muscarinic receptor tagged with marker mCherry (hM3Dq-mCherry), exclusively activated by the otherwise inert ligand- clozepine N-oxide (CNO), was expressed in the oxytocin cells of the paraventricular nuclei of the hypothalamus, in Cntnap2 KO mice and wild type controls, by means of stereotaxic injection of an AAV2 virus carrying the hM3Dg-mcherry construct. The expression of hM3Dq-mCherry was restricted to oxytocin cells by driving the expression under promotor for oxytocin. CNO was administered intraperitoneally at 5mg/kg, 30 min before testing.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test - Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_Fenobam

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of Fenobam, which is a mGlur5 agonist, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_Flumazenil

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of Flumazenil, which is a benzodiazepine receptor agonist , or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_Fluoxetine

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of Fluoxetine, which is an serotonin reuptake inhibitor, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_MC4R-Ag

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered MC4R agonist at 7.5 mg/kg (i.p.) 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_MC4R-Ag-OXTR-Ant

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered OXTR antagonist (L371,257) intranasally at 300ug/kg, followed by MC4R agonist at 7.5 mg/kg (i.p.), followed by 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXT-OXTR-Ant

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered an oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by oxytocin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXTR-Ant_AVP

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered with oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by AVP at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXTR-Ant_MC4R-Ag

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered OXTR antagonist (L371,257) intranasally at 300ug/kg, followed by MC4R agonist at 7.5 mg/kg (i.p.), followed by 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXTR-Ant_OXT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered an oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by oxytocin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_Oxytocin-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.)of oxytocin, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test 6-8 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_Oxytocin-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered oxytocin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.A group of these animals were also tested a 1-9 hrs after drug administration.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype Hyperactivity Refractory Open field test 4-6 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2015)
Repetitive behavior Self grooming: perseveration Refractory Grooming behavior assessments: scored for 10 min in a new cage after 10 min of habituation 4-6 weeks Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory Pain or nociception Refractory Hot plate test 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test: juvenile 4-6 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory Spatial working memory Refractory T-maze test: spontaneous alternation 4-6 weeks Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_Oxytocin-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO pups were treated with a daily administration of oxytocin at ~ 200ug/kg or saline intranasally between {P7- P21 and tested at P30.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2015)
Motor phenotype - Not Reported - - Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Oxytocin expressing Ameliorated Immunohistochemistry: stereology 4 weeks Peagarikano O , et al. (2015)
Neurophysiology Neurotransmitter release: neurohypophysial Ameliorated Radioimmunoassay (RIA) 4 weeks Peagarikano O , et al. (2015)
Repetitive behavior - Not Reported - - Peagarikano O , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2015)
Sensory - Not Reported - - Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4 weeks Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test 4 weeks Peagarikano O , et al. (2015)
Communications - Not Reported - - Peagarikano O , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2015)
Learning & memory - Not Reported - - Peagarikano O , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_PV

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Cntnap2 null mutant mice with a temporally precise reduction in E:I balance in the medial prefrontal cortex (mPFC) generated by optogenetically increasing the excitability of inhibitory parvalbumin (PV) neurons in a real-time and reversible manner. PV:Cre homozygous mice were bred with cntnap2 KO male mice for several generations to obtain PV:Cre homozygous, Cntnap2 wildtype, heterozygous and null mice. AAV5-EF1a::DIO-SSFO-eYFP was injected into the medial prefrontal cortex to selectively express the microbial stabilized step-function opsin (SSFO) in mouse parvalbumin neurons. Activation of SSFO in PV neurons by a single pulse of blue light (2 second light pulse of wavelength 473 nm) resulted in the neurons requiring lower inward-current amplitudes to generate action potentials. This indicated SSFO activation increased the excitability of the inhibitory PV neurons.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Selimbeyoglu A , et al. (2017)
Motor phenotype Spontaneous Movement Restored Open field test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Restored Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation Ameliorated Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Repetitive behavior - Not Reported - - Selimbeyoglu A , et al. (2017)
Seizure - Not Reported - - Selimbeyoglu A , et al. (2017)
Sensory - Not Reported - - Selimbeyoglu A , et al. (2017)
Social behavior Social interaction Restored Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Social behavior Inanimate object preference Ameliorated Novel object recognition test Adult Selimbeyoglu A , et al. (2017)
Communications - Not Reported - - Selimbeyoglu A , et al. (2017)
Developmental profile - Not Reported - - Selimbeyoglu A , et al. (2017)
Emotion - Not Reported - - Selimbeyoglu A , et al. (2017)
Homeostasis - Not Reported - - Selimbeyoglu A , et al. (2017)
Immune response - Not Reported - - Selimbeyoglu A , et al. (2017)
Learning & memory - Not Reported - - Selimbeyoglu A , et al. (2017)
Maternal behavior - Not Reported - - Selimbeyoglu A , et al. (2017)
Molecular profile - Not Reported - - Selimbeyoglu A , et al. (2017)

M_CNTNAP2_5_KO_HM_PY

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Cntnap2 null mutant mice with a temporally precise reduction in E:I balance in the medial prefrontal cortex (mPFC) by optogenetically decreasing the excitability of excitatory pyramidal neurons in a real-time and reversible manner. SwiChR++, a blue lightactivated bistable chloride channel, was selectively expressed in excitatory pyramidal neurons by injection of AAV8-CKIIa-SwiChR++-eYFP into the medial prefrontal cortex.1 second pulses of 473-nm wavelength light at 1-min intervals were used to activate SwiChR++.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Selimbeyoglu A , et al. (2017)
Motor phenotype Spontaneous Movement Restored Open field test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Restored Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Selimbeyoglu A , et al. (2017)
Neurophysiology - Not Reported - - Selimbeyoglu A , et al. (2017)
Repetitive behavior - Not Reported - - Selimbeyoglu A , et al. (2017)
Seizure - Not Reported - - Selimbeyoglu A , et al. (2017)
Sensory - Not Reported - - Selimbeyoglu A , et al. (2017)
Social behavior Social interaction Ameliorated Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Social behavior Inanimate object preference Ameliorated Novel object recognition test Adult Selimbeyoglu A , et al. (2017)
Communications - Not Reported - - Selimbeyoglu A , et al. (2017)
Developmental profile - Not Reported - - Selimbeyoglu A , et al. (2017)
Emotion - Not Reported - - Selimbeyoglu A , et al. (2017)
Homeostasis - Not Reported - - Selimbeyoglu A , et al. (2017)
Immune response - Not Reported - - Selimbeyoglu A , et al. (2017)
Learning & memory - Not Reported - - Selimbeyoglu A , et al. (2017)
Maternal behavior - Not Reported - - Selimbeyoglu A , et al. (2017)
Molecular profile - Not Reported - - Selimbeyoglu A , et al. (2017)

M_CNTNAP2_5_KO_HM_Risperidone

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO mice were treated with risperidone or vehicle for 7-10 days.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2011)
Motor phenotype General locomotor activity Restored Open field test - Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2011)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2011)
Repetitive behavior Perseveration Restored T-maze test: spontaneous alternation - Peagarikano O , et al. (2011)
Seizure - Not Reported - - Peagarikano O , et al. (2011)
Sensory Pain or nociception Refractory Hot plate test - Peagarikano O , et al. (2011)
Social behavior Social interaction Refractory Three-chamber social approach test Unreported Peagarikano O , et al. (2011)
Social behavior Nest building behavior Restored General observations - Peagarikano O , et al. (2011)
Communications - Not Reported - - Peagarikano O , et al. (2011)
Developmental profile - Not Reported - - Peagarikano O , et al. (2011)
Emotion - Not Reported - - Peagarikano O , et al. (2011)
Homeostasis - Not Reported - - Peagarikano O , et al. (2011)
Immune response - Not Reported - - Peagarikano O , et al. (2011)
Learning & memory Object recognition memory Restored General observations Unreported Peagarikano O , et al. (2011)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2011)
Molecular profile - Not Reported - - Peagarikano O , et al. (2011)

M_CNTNAP2_6_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Targeted replacement of exon 1 of Cntnap2 gene maintained as a heterozygous.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - -
Circadian sleep/wake cycle - Not Reported - - Antoine MW , et al. (2019)
Circadian sleep/wake cycle - Not Reported - - Kloth AD , et al. (2015)
Circadian sleep/wake cycle - Not Reported - - Peagarikano O , et al. (2011)
Motor phenotype - Not Reported - - -
Motor phenotype - Not Reported - - Antoine MW , et al. (2019)
Motor phenotype - Not Reported - - Kloth AD , et al. (2015)
Motor phenotype Motor coordination and balance No Change Accelerating rotarod test - Peagarikano O , et al. (2011)
Motor phenotype General locomotor activity: Ambulatory activity No Change Open field test - Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - -
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Antoine MW , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Peagarikano O , et al. (2011)
Neurophysiology Neuronal activation No Change Whole-cell voltage clamp P17-P23 -
Neurophysiology Synaptic transmission Increased Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Stimulus-spike relationship: inhibitory Decreased Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents Decreased Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Decreased Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No Change Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No Change Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Network excitability No Change Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Network excitability No Change Whole-cell current clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Membrane potential No Change Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Intrinsic membrane properties No Change Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology EPSP-spike relationship Decreased Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Decay kinetics of miniature post synaptic currents No Change Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Decay kinetics of miniature post synaptic currents No Change Whole-cell current clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Action potential properties: amplitude, rate of depolarization and repolarization No Change Whole-cell current clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Action potential properties: amplitude, rate of depolarization and repolarization Increased Whole-cell voltage clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology Action potential firing Increased Cell-attached patch clamp P17-P23 Antoine MW , et al. (2019)
Neurophysiology - Not Reported - - Kloth AD , et al. (2015)
Neurophysiology - Not Reported - - Peagarikano O , et al. (2011)
Repetitive behavior - Not Reported - - -
Repetitive behavior - Not Reported - - Antoine MW , et al. (2019)
Repetitive behavior - Not Reported - - Kloth AD , et al. (2015)
Repetitive behavior Self grooming: perseveration No Change Grooming behavior assessments - Peagarikano O , et al. (2011)
Seizure - Not Reported - - -
Seizure - Not Reported - - Antoine MW , et al. (2019)
Seizure - Not Reported - - Kloth AD , et al. (2015)
Seizure - Not Reported - - Peagarikano O , et al. (2011)
Sensory Sensory-evoked response: excitation: tactile stimulus Decreased Whole-cell voltage clamp P42-P92 -
Sensory - Not Reported - - -
Sensory - Not Reported - - Antoine MW , et al. (2019)
Sensory - Not Reported - - Kloth AD , et al. (2015)
Sensory Pain or nociception No Change Hot plate test - Peagarikano O , et al. (2011)
Social behavior - Not Reported - - -
Social behavior - Not Reported - - Antoine MW , et al. (2019)
Social behavior - Not Reported - - Kloth AD , et al. (2015)
Social behavior Social approach No Change Three-chamber social approach test - Peagarikano O , et al. (2011)
Communications - Not Reported - - -
Communications - Not Reported - - Antoine MW , et al. (2019)
Communications - Not Reported - - Kloth AD , et al. (2015)
Communications Ultrasonic vocalization: Isolation induced No Change Monitoring ultrasonic vocalizations P3,P6,P9,P12 Peagarikano O , et al. (2011)
Developmental profile - Not Reported - - -
Developmental profile - Not Reported - - Antoine MW , et al. (2019)
Developmental profile - Not Reported - - Kloth AD , et al. (2015)
Developmental profile - Not Reported - - Peagarikano O , et al. (2011)
Emotion - Not Reported - - -
Emotion - Not Reported - - Antoine MW , et al. (2019)
Emotion - Not Reported - - Kloth AD , et al. (2015)
Emotion - Not Reported - - Peagarikano O , et al. (2011)
Homeostasis - Not Reported - - -
Homeostasis - Not Reported - - Antoine MW , et al. (2019)
Homeostasis - Not Reported - - Kloth AD , et al. (2015)
Homeostasis - Not Reported - - Peagarikano O , et al. (2011)
Immune response - Not Reported - - -
Immune response - Not Reported - - Antoine MW , et al. (2019)
Immune response - Not Reported - - Kloth AD , et al. (2015)
Immune response - Not Reported - - Peagarikano O , et al. (2011)
Learning & memory - Not Reported - - -
Learning & memory - Not Reported - - Antoine MW , et al. (2019)
Learning & memory Eye blink conditioning: extinction and reactivation No Change Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning No Change Eyeblink conditioning: probability of generating a response and response amplitude 2-4 months Kloth AD , et al. (2015)
Learning & memory Spatial working memory No Change T-maze test - Peagarikano O , et al. (2011)
Learning & memory Spatial learning No Change Morris water maze test - Peagarikano O , et al. (2011)
Learning & memory Cognitive flexibility No Change Morris water maze test - Peagarikano O , et al. (2011)
Maternal behavior - Not Reported - - -
Maternal behavior - Not Reported - - Antoine MW , et al. (2019)
Maternal behavior - Not Reported - - Kloth AD , et al. (2015)
Maternal behavior - Not Reported - - Peagarikano O , et al. (2011)
Molecular profile - Not Reported - - -
Molecular profile - Not Reported - - Antoine MW , et al. (2019)
Molecular profile - Not Reported - - Kloth AD , et al. (2015)
Molecular profile - Not Reported - - Peagarikano O , et al. (2011)

M_CNTNAP2_7_KO_HM_LPS

Model Type: Multifactorial
Model Genotype: Homozygous

Mutation:

Homozygous Cntnap2 KO mice are obtained by crossing heterozygous Cntnap2 KO mice and subjecting the pregnant females to a MIA at gestational day GD7 (0.30 mg/kg LPS in saline by subcutaneous injections).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Schaafsma SM , et al. (2017)
Motor phenotype General locomotor activity Increased Open field test P40 Schaafsma SM , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: CRH No Change Quantitative PCR (qRT-PCR) P40 Schaafsma SM , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: CRH Decreased Quantitative PCR (qRT-PCR) P40 Schaafsma SM , et al. (2017)
Neurophysiology - Not Reported - - Schaafsma SM , et al. (2017)
Repetitive behavior - Not Reported - - Schaafsma SM , et al. (2017)
Seizure - Not Reported - - Schaafsma SM , et al. (2017)
Sensory - Not Reported - - Schaafsma SM , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social dishabituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P3 Schaafsma SM , et al. (2017)
Developmental profile - Not Reported - - Schaafsma SM , et al. (2017)
Emotion Anxiety No Change Open field test P40 Schaafsma SM , et al. (2017)
Homeostasis - Not Reported - - Schaafsma SM , et al. (2017)
Immune response - Not Reported - - Schaafsma SM , et al. (2017)
Learning & memory - Not Reported - - Schaafsma SM , et al. (2017)
Maternal behavior - Not Reported - - Schaafsma SM , et al. (2017)
Molecular profile Gene expression No Change Quantitative PCR (qRT-PCR) P40 Schaafsma SM , et al. (2017)
Molecular profile Chromatin modification No Change Quantitative PCR (qRT-PCR): chromatin immunoprecipitation (ChIP) P40 Schaafsma SM , et al. (2017)
Molecular profile Chromatin modification Decreased Quantitative PCR (qRT-PCR): chromatin immunoprecipitation (ChIP) P40 Schaafsma SM , et al. (2017)

M_CNTNAP2_9_KO_HM_MIA

Model Type: Multifactorial
Model Genotype: Homozygous

Mutation:

Homozygous Cntnap2 KO mice are obtained by crossing heterozygous Cntnap2 KO mice and subjecting the pregnant females to a MIA at gestational day GD7 (0.30 mg/kg LPS in saline by subcutaneous injections).

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Schaafsma SM , et al. (2017)
Motor phenotype - Not Reported - - Schaafsma SM , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schaafsma SM , et al. (2017)
Neurophysiology - Not Reported - - Schaafsma SM , et al. (2017)
Repetitive behavior - Not Reported - - Schaafsma SM , et al. (2017)
Seizure - Not Reported - - Schaafsma SM , et al. (2017)
Sensory - Not Reported - - Schaafsma SM , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Communications - Not Reported - - Schaafsma SM , et al. (2017)
Developmental profile - Not Reported - - Schaafsma SM , et al. (2017)
Emotion - Not Reported - - Schaafsma SM , et al. (2017)
Homeostasis - Not Reported - - Schaafsma SM , et al. (2017)
Immune response - Not Reported - - Schaafsma SM , et al. (2017)
Learning & memory - Not Reported - - Schaafsma SM , et al. (2017)
Maternal behavior - Not Reported - - Schaafsma SM , et al. (2017)
Molecular profile - Not Reported - - Schaafsma SM , et al. (2017)
Other CNTNAP2 Rescue Models(15 Models)
M_CNTNAP2_2_KO_HM 1 Genetic Genetic Human CNTNAP2
M_CNTNAP2_5_KO_HM 3 Genetic Pharmaceutical Arginine vasopressin
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Arginine vasopressin;L371,257
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Arginine vasopressin;Relcovaptan
M_CNTNAP2_5_KO_HM 1 Genetic Genetic DREADD-Oxytocin neurons
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Fenobam
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Flumazenil
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Fluoxetine
M_CNTNAP2_5_KO_HM 2 Genetic Pharmaceutical Ro27-3225
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Ro27-3225;L371,257
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Oxytocin;L371,257
M_CNTNAP2_5_KO_HM 4 Genetic Pharmaceutical Oxytocin
M_CNTNAP2_5_KO_HM 1 Genetic Procedural Parvalbumin neuron activation
M_CNTNAP2_5_KO_HM 1 Genetic Procedural Pyramidal neuron activation
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Risperidone
CNVs associated with CNTNAP2(1 Models)
7q35-q36.1 4 Deletion-Duplication 7  /  5
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