Genetic Mouse Models / CNTNAP2

CNTNAP2 contactin associated protein-like 2

Model Species
Mus musculus
Gene Aliases
5430425M22Rik, Caspr2, mKIAA0868
Reports
20
Associated Human Genes
CNTNAP2
Models / Rescue Models
53 / 34
Rescue Model
-
Model Summary

Axon-glia interactions mediated by Cntnap2 and Tag-1 s allow myelinating glial cells to organize ion channels in the underlying axonal membrane.

External Links
Entrez GeneMouse Genome InformaticsAllen Brain Atlas
Reports related to CNTNAP2 (20 Reports)
# Type Title Author, Year
1 Primary Juxtaparanodal clustering of Shaker-like K channels in myelinated axons depends on Caspr2 and TAG-1. Poliak S , et al. (2003)
2 Additional Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B. Horresh I , et al. (2010)
3 Additional Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Peagarikano O , et al. (2011)
4 Additional Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Peagarikano O , et al. (2015)
5 Additional Cerebellar associative sensory learning defects in five mouse autism models. Kloth AD , et al. (2015)
6 Additional Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder. Brunner D , et al. (2015)
7 Additional Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology. Thomas AM , et al. (2016)
8 Additional Sex-specific gene-environment interactions underlying ASD-like behaviors. Schaafsma SM , et al. (2017)
9 Additional Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice. Selimbeyoglu A , et al. (2017)
10 Additional CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Gao R , et al. (2018)
11 Additional Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models. Antoine MW , et al. (2019)
12 Additional Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Orefice LL , et al. (2019)
13 Additional IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders </title> ()
14 Additional Tau Reduction Prevents Key Features of Autism in Mouse Models Tai C et al. (2020)
15 Additional Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex Sacai H et al. (2020)
16 Additional Dissecting the contribution of host genetics and the microbiome in complex behaviors Buffington SA et al. (2021)
17 Additional Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse Choe KY et al. (2022)
18 Additional Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2 -/- mice Balasco L et al. (2022)
19 Additional - Tripathi MK et al. (2023)
20 Additional - et al. ()
Show all Construct Details Show all Phenotypic Profiles

M_CNTNAP2_10_KI_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Cntnap2^tlacz/ knockin allele abolishes contactin associated protein-like 2 gene function and instead expresses a tau-LacZ gene and a neo cassette from the Cntnap2 promoter/enhancer elements.

Allele Type: LOF Knockin
Strain of Origin: -
Genetic Background: C57BL/6J*129/SvEv*CD1

Es cell line: -
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 6-8 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Increased Response to air puff 6-8 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Increased Prepulse inhibition 6-8 weeks Orefice LL , et al. (2019)

M_CNTNAP2_10_KI_HT_ISOGUVACINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Cntnap2^tlacz/ knockin allele abolishes contactin associated protein-like 2 gene function and instead expresses a tau-LacZ gene and a neo cassette from the Cntnap2 promoter/enhancer elements. Isoguvacine, 2 mg/kg, i.p., was administered from P1 to P42 to test if it ameliorated tactile hypersensitivity in ASD models with fewer adverse effects than brain-penetrating benzodiazepines such as midazolam.

Allele Type: LOF Knockin
Strain of Origin: -
Genetic Background: C57BL/6J*129/SvEv*CD1

Es cell line: -
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Sensory Startle response: acoustic stimulus No adverse effect Acoustic startle reflex test 6 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Restored Response to air puff 6 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Restored Prepulse inhibition 6 weeks Orefice LL , et al. (2019)

M_CNTNAP2_11_KD

Model Type: Genetic LOF
Model Genotype: Wildtype

Mutation:

Knockdown of cntnap2 in layer 2/3 pyramidal neurons of the developing mouse prefrontal cortex. pregnant icr mice at e14–15 were injected intraperitoneally with egfp-pcag plasmid vectors carrying rnai to knockdown the expression of cntnap2 pyramidal neurons.

Allele Type: Wildtype
Strain of Origin: ICR
Genetic Background: ICR

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Synaptic transmission: inhibitory Decreased Whole-cell patch clamp P16 -P24, 8 -11 weeks Sacai H et al. (2020)
Neurophysiology Synaptic transmission: excitatory Decreased Whole-cell patch clamp P16 -P24, 8 - 11 weeks Sacai H et al. (2020)
Neurophysiology Synaptic transmission Abnormal Whole-cell patch clamp P16 -P24, 8 - 11 weeks Sacai H et al. (2020)
Neurophysiology Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission No change Whole-cell patch clamp 2-3 weeks, 8 - 11 weeks Sacai H et al. (2020)
Neurophysiology Stimulus-spike relationship: inhibitory Decreased Whole-cell patch clamp P16 -P24, 8 -11 weeks Sacai H et al. (2020)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp 2-3 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic currents: excitatory No change Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp P16 -P24, 8 -11 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic current amplitude: excitatory Decreased Whole-cell patch clamp P16 -P24, 8 -11 weeks Sacai H et al. (2020)
Neurophysiology EPSP-spike relationship Decreased Whole-cell patch clamp P16 -P24, 8 -11 weeks Sacai H et al. (2020)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Repetitive behavior Self grooming No change Grooming behavior assessments 8 - 18 weeks Sacai H et al. (2020)
Repetitive behavior Repetitive digging No change Marble-burying test 8 - 18 weeks Sacai H et al. (2020)
Social behavior Social interaction Decreased Reciprocal social interaction test 8 - 18 weeks Sacai H et al. (2020)
Social behavior Social approach Decreased Partition test 8 - 18 weeks Sacai H et al. (2020)
Social behavior Social approach Decreased Three-chamber social approach test 8 - 18 weeks Sacai H et al. (2020)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P7 Sacai H et al. (2020)
Emotion Exploratory activity No change Novel object exploration test 8 - 18 weeks Sacai H et al. (2020)
Emotion Depression No change Forced swim test 8 - 18 weeks Sacai H et al. (2020)
Emotion Depression Increased Tail suspension test 8 - 18 weeks Sacai H et al. (2020)
Emotion Anxiety No change Elevated plus maze test 8 - 18 weeks Sacai H et al. (2020)
Emotion Anxiety No change Light-dark exploration test 8 - 18 weeks Sacai H et al. (2020)
Learning & memory Spatial working memory No change Y-maze test 8 - 18 weeks Sacai H et al. (2020)
Learning & memory Cognitive flexibility No change Operant conditioning paradigm 8 - 18 weeks Sacai H et al. (2020)
Molecular profile Targeted expression Decreased Immunohistochemistry 8 - 18 weeks Sacai H et al. (2020)

M_CNTNAP2_11_KD_CX-546

Model Type: RESCUE-Pharmaceutical
Model Genotype: Wildtype

Mutation:

Intraperitoneal injection of cx546 (25 mg/kg) or vehicle was performed 30 min before the test in cntnap2 knockdown mice.

Allele Type: Wildtype
Strain of Origin: ICR
Genetic Background: ICR

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neurophysiology Synaptic transmission Restored Whole-cell patch clamp P16 -P24, 8 - 11 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic currents: excitatory Side effect Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic current frequency: inhibitory Refractory Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No adverse effect Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Neurophysiology Decay kinetics of miniature post synaptic currents Side effect Whole-cell patch clamp 8 - 18 weeks Sacai H et al. (2020)
Social behavior Social interaction Restored Reciprocal social interaction test 8 - 18 weeks Sacai H et al. (2020)
Social behavior Social approach Restored Partition test 8 - 18 weeks Sacai H et al. (2020)
Molecular profile Targeted expression Restored Immunohistochemistry 8 - 18 weeks Sacai H et al. (2020)

M_CNTNAP2_11_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene. A subset of mice were homozygous for Cntnap2 KO and heterozygous for Oxt-Cre (obtained from JAX, #024234) for DREADD experiments targetted to PVN OXT neurons using AAV-OXT-hM3D(Gq)-mCherry or AAVhSyn-DIO-hM3D(Gq)-mCherry; M_CNTNAP2_1_KO_HM crossed to C57BL/6J background for 12 generations

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * ICR * C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt no change Autoradiographic analysis Adult (8 weeks or orlder) Choe KY et al. (2022)
Neurophysiology Neuronal activation increased Fluorescence microscopy Adult (8 weeks or orlder) Choe KY et al. (2022)
Neurophysiology Neuronal activation increased Functional magnetic resonance imaging (FMRI)-resting state Adult (8 weeks or orlder) Choe KY et al. (2022)
Neurophysiology Neuronal activation increased Fluorescence microscopy Adult (8 weeks or orlder) Choe KY et al. (2022)
Neurophysiology Functional magnetic resonance imaging: connectivity abnormal Functional magnetic resonance imaging (FMRI)-resting state Adult (8 weeks or orlder) Choe KY et al. (2022)

M_CNTNAP2_11_KO_HM_chETA

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene. in vivo optogenetic stimulation of NAcSh-targeted OXT release via AAV1-Ef1a-DIO ChETA-EYFP

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * ICR * C57BL/6J

Es cell line: R1
Model Source: PMID 34932941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Social behavior Social interaction ameliorated Reciprocal social interaction test Adult (8 weeks or orlder) Choe KY et al. (2022)

M_CNTNAP2_11_KO_HM_OXT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene. OXT (Sigma, 1 mg/kg i.p. at 1 mg/mL) or saline of the same volume was administeredvia a catheter

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * ICR * C57BL/6J

Es cell line: R1
Model Source: PMID 34932941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neurophysiology Functional magnetic resonance imaging: connectivity ameliorated Functional magnetic resonance imaging (FMRI)-resting state Adult (8 weeks or orlder) Choe KY et al. (2022)

M_CNTNAP2_11_KO_HM_TGOT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene. bilateral microinjection of TGOT (OXTR agonist) into nucleus accumbens

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * ICR * C57BL/6J

Es cell line: R1
Model Source: PMID 34932941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Social behavior Social interaction ameliorated Reciprocal social interaction test Adult (8 weeks or orlder) Choe KY et al. (2022)

M_CNTNAP2_12_KI_HT_I1253T

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Cntnap2^I1254T knock-in mice were generated using CRISPR–Cas9-mediated gene targeting. The targeted missense mutation changes an ATA DNA sequence to ACG in exon 23, which results in an isoleucine to threonine amino acid change in the CNTNAP2 protein. The I1254T mutation in the CNTNAP2 protein corresponds to the pathogenic I1253T mutation in ASD patients. Heterozygous mice carry one copy of the mutant allele.

Allele Type: ASD mutation
Strain of Origin: Not specified
Genetic Background: Not specified

Es cell line: Not specified
Model Source: Weihong Song
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 7 weeks et al. ()
Repetitive behavior Self grooming Increased Grooming behavior assessments 3 weeks et al. ()
Social behavior Social approach Decreased Three-chamber social approach test 7 weeks et al. ()
Social behavior Juvenile play No change Reciprocal social interaction test 3 weeks et al. ()
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations P3-P12 et al. ()
Developmental profile Size/growth No change Body weight measurement 3-8 weeks et al. ()
Developmental profile Mortality/lethality No change Genotypic ratio of progeny from heterozygous parents 7 weeks et al. ()
Learning & memory Spatial working memory Decreased T-maze test 7 weeks et al. ()

M_CNTNAP2_12_KI_HT_I1253T_C79

Model Type: RESCUE-Genetic
Model Genotype: Heterozygous

Mutation:

Cntnap2^I1254T heterozygous knock-in mice were injected in the medial prefrontal cortex at the age of 3 weeks with the adeno-associated virus (AAV) vector expressing CNTNAP2-C79 protein (AAV-C79) and AAV-EGFP (as the control). C79 is the C-terminal peptide resulting from CNTNAP2 cleavage by alpha-secretase ADAM10.

Allele Type: ASD mutation
Strain of Origin: Not specified
Genetic Background: Not specified

Es cell line: Not specified
Model Source: Weihong Song
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Social behavior Social approach Restored Three-chamber social approach test 7 weeks et al. ()
Learning & memory Spatial working memory Restored T-maze test 7 weeks et al. ()

M_CNTNAP2_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * ICR

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Poliak S , et al. (2003)
Motor phenotype Ataxia No change General observations 20 months Poliak S , et al. (2003)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Electron microscopy Adult Poliak S , et al. (2003)
Neurophysiology NA Not reported NA NA Poliak S , et al. (2003)
Repetitive behavior NA Not reported NA NA Poliak S , et al. (2003)
Seizure NA Not reported NA NA Poliak S , et al. (2003)
Sensory NA Not reported NA NA Poliak S , et al. (2003)
Social behavior NA Not reported NA NA Poliak S , et al. (2003)
Physiological parameters NA Not reported NA NA Poliak S , et al. (2003)
Communications NA Not reported NA NA Poliak S , et al. (2003)
Developmental profile Size/growth Decreased General observations P0 Poliak S , et al. (2003)
Emotion NA Not reported NA NA Poliak S , et al. (2003)
Immune response NA Not reported NA NA Poliak S , et al. (2003)
Learning & memory NA Not reported NA NA Poliak S , et al. (2003)
Maternal behavior NA Not reported NA NA Poliak S , et al. (2003)
Molecular profile Protein localization: synapse Decreased Immunohistochemistry Adult Poliak S , et al. (2003)

M_CNTNAP2_2_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with a oppositely directed neo gene (Reference: PMID 12963709).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: BALB/c * C57BL/6 * 129S1/Sv * 129X1/SvJ * ICR

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Horresh I , et al. (2010)
Motor phenotype NA Not reported NA NA Horresh I , et al. (2010)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Horresh I , et al. (2010)
Neurophysiology NA Not reported NA NA Horresh I , et al. (2010)
Repetitive behavior NA Not reported NA NA Horresh I , et al. (2010)
Seizure NA Not reported NA NA Horresh I , et al. (2010)
Sensory NA Not reported NA NA Horresh I , et al. (2010)
Social behavior NA Not reported NA NA Horresh I , et al. (2010)
Physiological parameters NA Not reported NA NA Horresh I , et al. (2010)
Communications NA Not reported NA NA Horresh I , et al. (2010)
Developmental profile NA Not reported NA NA Horresh I , et al. (2010)
Emotion NA Not reported NA NA Horresh I , et al. (2010)
Immune response NA Not reported NA NA Horresh I , et al. (2010)
Learning & memory NA Not reported NA NA Horresh I , et al. (2010)
Maternal behavior NA Not reported NA NA Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Abnormal Immunohistochemistry Unreported Horresh I , et al. (2010)

M_CNTNAP2_2_KO_HM_HCNTNAP2

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Transgene of HA-tagged construct of human Cntnap2 cDNA, C2FL (full-length), in Cntnap2 knockout mice (PMID 112963709).

Allele Type: Knockout
Strain of Origin: CB6F1 (Transgene); (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: BALB/c * C57BL/6 * 129S1/Sv * 129X1/SvJ * ICR

Es cell line: -
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Horresh I , et al. (2010)
Motor phenotype NA Not reported NA NA Horresh I , et al. (2010)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Horresh I , et al. (2010)
Neurophysiology NA Not reported NA NA Horresh I , et al. (2010)
Repetitive behavior NA Not reported NA NA Horresh I , et al. (2010)
Seizure NA Not reported NA NA Horresh I , et al. (2010)
Sensory NA Not reported NA NA Horresh I , et al. (2010)
Social behavior NA Not reported NA NA Horresh I , et al. (2010)
Physiological parameters NA Not reported NA NA Horresh I , et al. (2010)
Communications NA Not reported NA NA Horresh I , et al. (2010)
Developmental profile NA Not reported NA NA Horresh I , et al. (2010)
Emotion NA Not reported NA NA Horresh I , et al. (2010)
Immune response NA Not reported NA NA Horresh I , et al. (2010)
Learning & memory NA Not reported NA NA Horresh I , et al. (2010)
Maternal behavior NA Not reported NA NA Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Restored Immunohistochemistry Unreported Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Restored Immunohistochemistry Unreported Horresh I , et al. (2010)

M_CNTNAP2_3_KO_HM_HCNTNAP2D4.1

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Transgene of HA-tagged construct of human Cntnap2 cDNA with 4.1B binding domain deletion, C2d4.1 (delection of amino acids R1298 to H1304), in Cntnap2 knockout mice (PMID 12963709).

Allele Type: Humanized LOF mutation
Strain of Origin: CB6F1 (Transgene); (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: BALB/c * C57BL/6 * 129S1/Sv * 129X1/SvJ * ICR

Es cell line: -
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Horresh I , et al. (2010)
Motor phenotype NA Not reported NA NA Horresh I , et al. (2010)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Horresh I , et al. (2010)
Neurophysiology NA Not reported NA NA Horresh I , et al. (2010)
Repetitive behavior NA Not reported NA NA Horresh I , et al. (2010)
Seizure NA Not reported NA NA Horresh I , et al. (2010)
Sensory NA Not reported NA NA Horresh I , et al. (2010)
Social behavior NA Not reported NA NA Horresh I , et al. (2010)
Physiological parameters NA Not reported NA NA Horresh I , et al. (2010)
Communications NA Not reported NA NA Horresh I , et al. (2010)
Developmental profile NA Not reported NA NA Horresh I , et al. (2010)
Emotion NA Not reported NA NA Horresh I , et al. (2010)
Immune response NA Not reported NA NA Horresh I , et al. (2010)
Learning & memory NA Not reported NA NA Horresh I , et al. (2010)
Maternal behavior NA Not reported NA NA Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry Unreported Horresh I , et al. (2010)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry Unreported Horresh I , et al. (2010)

M_CNTNAP2_5_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of Cntnap2 gene with an oppositely directed neo gene. In Gao et al. 2018 (PMID 29610457) Cntnap2 null mutant mice were crossed with heterozygous transgenic mice carrying the interneuron-specific Gad1-eGFP reporter to generate Cntnap2 null mutant (test animals) and wildtype (controls) mice with the reporter. In PMID 31853066 mice were inbred after colonizing with segmented filamentous bacteria (SFB) from donor mice.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Category Signaling: nitric oxide pathway Increased Griess reagent assay unreported Tripathi MK et al. (2023)
Category Signaling: nitric oxide pathway Increased Cyclic nucleotide activity assay unreported Tripathi MK et al. (2023)
Circadian sleep/wake cycle NA Not reported NA NA -
Circadian sleep/wake cycle NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA Antoine MW , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Gao R , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Schaafsma SM , et al. (2017)
Circadian sleep/wake cycle Sleep pattern Abnormal Electroencephalogram (eeg) 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Rapid eye movement sleep (rems) Decreased Electroencephalogram (eeg) 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle No change Electromyogram (emg) 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Circadian rhythms: timing/phases of locomotor activity Abnormal Electromyogram (emg) 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle Circadian rhythms: timing/phases of locomotor activity Abnormal Body temperature measurement 4, 8 months Thomas AM , et al. (2016)
Circadian sleep/wake cycle NA Not reported NA NA Brunner D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Kloth AD , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2011)
Motor phenotype NA Not reported NA NA -
Motor phenotype General locomotor activity: ambulatory activity Increased Open field test 7 weeks et al. ()
Motor phenotype General locomotor activity: ambulatory activity No change Open field test unreported Tripathi MK et al. (2023)
Motor phenotype General locomotor activity: ambulatory activity Increased Open field test 3-6 months Balasco L et al. (2022)
Motor phenotype NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA Antoine MW , et al. (2019)
Motor phenotype NA Not reported NA NA Gao R , et al. (2018)
Motor phenotype Spontaneous movement Increased Open field test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Increased Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Increased Open field test P40 Schaafsma SM , et al. (2017)
Motor phenotype NA Not reported NA NA Thomas AM , et al. (2016)
Motor phenotype Righting response Decreased Righting reflex test P4, p7 Brunner D , et al. (2015)
Motor phenotype Righting response Decreased Negative geotaxis test P4, p7 Brunner D , et al. (2015)
Motor phenotype Negative geotaxis No change Negative geotaxis test P4, p7, p15 Brunner D , et al. (2015)
Motor phenotype Jerky movement Increased Observation of repetitive behavior 3 months Brunner D , et al. (2015)
Motor phenotype General locomotor activity Increased Home cage behavior 3 months Brunner D , et al. (2015)
Motor phenotype Gait Decreased Footprint analysis 1 month, 2 months Brunner D , et al. (2015)
Motor phenotype Gait Decreased Running stride analysis 1 month, 2 months Brunner D , et al. (2015)
Motor phenotype Gait No change Running stride analysis 2-4 months Kloth AD , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype Motor coordination and balance Increased Accelerating rotarod test Unreported Peagarikano O , et al. (2011)
Motor phenotype General locomotor activity Increased Open field test Unreported Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: enteric neurons No change Immunohistochemistry 9 weeks -
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA -
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Decreased Western blot unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: inhibitory neurons Decreased Immunofluorescence staining unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: excitatory neurons Decreased Immunofluorescence staining unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Golgi-Cox staining unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Inhibitory neurons No change Quantitative PCR (qRT-PCR) 3-6 months Balasco L et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Excitatory neurons Increased Quantitative PCR (qRT-PCR) 3-6 months Balasco L et al. (2022)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Measurement of tissue weight 9-10 months Tai C et al. (2020)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Antoine MW , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity No change Sholl analysis 6 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis 5 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length No change Golgi-cox staining 6 months Gao R , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Golgi-cox staining 5 months Gao R , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Schaafsma SM , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Thomas AM , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Brunner D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Histology 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No change Sholl analysis 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity No change Sholl analysis 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: molecular layer thickness No change Histology 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: granule cell layer thickness No change Histology 2-4 months Kloth AD , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: oxytocin expressing Decreased Immunohistochemistry 4 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: oxytocin expressing No change Immunohistochemistry P7 Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Stereology 4 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Immunohistochemistry 4 weeks Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry P14 Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal migration Abnormal Immunohistochemistry P14 Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Abnormal Immunohistochemistry Unreported Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Histology 6 months Peagarikano O , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Abnormal Immunohistochemistry P7 Peagarikano O , et al. (2011)
Neurophysiology Action potential property: firing rate No change Whole-cell voltage clamp P42-p92 -
Neurophysiology Oxidative stress in neurons Increased Western blot unreported Tripathi MK et al. (2023)
Neurophysiology Functional magnetic resonance imaging: connectivity Increased Functional magnetic resonance imaging (FMRI)-resting state 3-6 months Balasco L et al. (2022)
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult, 2-5 months, 9-12 months ()
Neurophysiology Synaptic plasticity Decreased Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology NA Not reported NA NA Gao R , et al. (2018)
Neurophysiology Neuronal activation: novel object interaction Increased Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation: non-familiar social interaction Increased Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation: locomotion No change Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation: familiar social interaction Increased Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation Abnormal Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Neurophysiology NA Not reported NA NA Schaafsma SM , et al. (2017)
Neurophysiology NA Not reported NA NA Thomas AM , et al. (2016)
Neurophysiology NA Not reported NA NA Brunner D , et al. (2015)
Neurophysiology NA Not reported NA NA Kloth AD , et al. (2015)
Neurophysiology Neurotransmitter release: neurohypophysial Decreased Radioimmunoassay (ria) 4 weeks Peagarikano O , et al. (2015)
Neurophysiology Network excitability Decreased Calcium imaging 2-4 months Peagarikano O , et al. (2011)
Neurophysiology Action potential property: amplitude No change Calcium imaging 2-4 months Peagarikano O , et al. (2011)
Repetitive behavior NA Not reported NA NA -
Repetitive behavior Self grooming: perseveration Increased Novel cage test 3-4 months Tai C et al. (2020)
Repetitive behavior NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA Antoine MW , et al. (2019)
Repetitive behavior NA Not reported NA NA Gao R , et al. (2018)
Repetitive behavior NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Repetitive behavior NA Not reported NA NA Schaafsma SM , et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 8 weeks Thomas AM , et al. (2016)
Repetitive behavior NA Not reported NA NA Brunner D , et al. (2015)
Repetitive behavior NA Not reported NA NA Kloth AD , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior Self grooming: perseveration Increased General observations Unreported Peagarikano O , et al. (2011)
Repetitive behavior Perseveration Increased T-maze test Unreported Peagarikano O , et al. (2011)
Seizure NA Not reported NA NA -
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Decreased Electroencephalogram (eeg) 7-11 months Tai C et al. (2020)
Seizure NA Not reported NA NA ()
Seizure NA Not reported NA NA Antoine MW , et al. (2019)
Seizure NA Not reported NA NA Gao R , et al. (2018)
Seizure NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Seizure NA Not reported NA NA Schaafsma SM , et al. (2017)
Seizure Seizures No change Electroencephalogram (eeg) 4, 8 months Thomas AM , et al. (2016)
Seizure Absence seizures Increased Electroencephalogram (eeg) 4, 8 months Thomas AM , et al. (2016)
Seizure NA Not reported NA NA Brunner D , et al. (2015)
Seizure NA Not reported NA NA Kloth AD , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure Seizures Increased General observations 6 months Peagarikano O , et al. (2011)
Seizure Seizures Abnormal Electroencephalogram (eeg) 6 months Peagarikano O , et al. (2011)
Sensory NA Not reported NA NA -
Sensory Tactile memory Decreased Textured novel object recognition test (T-NORT) 3-6 months Balasco L et al. (2022)
Sensory Sensory-evoked response: excitation: tactile stimulus Increased In situ hybridization (ISH) 3-6 months Balasco L et al. (2022)
Sensory NA Not reported NA NA ()
Sensory NA Not reported NA NA Antoine MW , et al. (2019)
Sensory NA Not reported NA NA Gao R , et al. (2018)
Sensory NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Sensory NA Not reported NA NA Schaafsma SM , et al. (2017)
Sensory NA Not reported NA NA Thomas AM , et al. (2016)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 2 months Brunner D , et al. (2015)
Sensory Sensorimotor gating Increased Prepulse inhibition 2 months Brunner D , et al. (2015)
Sensory NA Not reported NA NA Kloth AD , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test Unreported Peagarikano O , et al. (2011)
Sensory Pain or nociception Increased Hot plate test Unreported Peagarikano O , et al. (2011)
Sensory Olfaction Increased Buried food test Unreported Peagarikano O , et al. (2011)
Social behavior NA Not reported NA NA -
Social behavior Social interaction Decreased Reciprocal social interaction test 7 weeks et al. ()
Social behavior Social approach Decreased Three-chamber social approach test 7 weeks et al. ()
Social behavior Social approach Decreased Three-chamber social approach test unreported Tripathi MK et al. (2023)
Social behavior Social scent marking or recognition Decreased Olfactory habituation-dishabituation test 7-11 months Tai C et al. (2020)
Social behavior Social interaction No change Reciprocal social interaction test 7-11 months Tai C et al. (2020)
Social behavior Social approach No change Three-chamber social approach test 7-11 months Tai C et al. (2020)
Social behavior Nest building behavior Decreased Nest building assay 7-11 months Tai C et al. (2020)
Social behavior Social approach Decreased Three-chamber social approach test Adult ()
Social behavior NA Not reported NA NA Antoine MW , et al. (2019)
Social behavior NA Not reported NA NA Gao R , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Social behavior Inanimate object preference Increased Novel object recognition test Adult Selimbeyoglu A , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social habituation No change Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social dishabituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social interaction Decreased Reciprocal social interaction test 7 weeks Thomas AM , et al. (2016)
Social behavior Social memory No change Three-chamber social approach test 2 months Brunner D , et al. (2015)
Social behavior Social interaction No change Reciprocal social interaction test 6.4-7.4 weeks Brunner D , et al. (2015)
Social behavior Social interaction No change Three-chamber social approach test 2 months Brunner D , et al. (2015)
Social behavior Mating behavior Decreased Scent marking test 2 months Brunner D , et al. (2015)
Social behavior Mating behavior No change Scent marking test 2 months Brunner D , et al. (2015)
Social behavior NA Not reported NA NA Kloth AD , et al. (2015)
Social behavior Social interaction Decreased Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social interaction Decreased Three-chamber social approach test Unreported Peagarikano O , et al. (2011)
Social behavior Nest building behavior Decreased General observations Unreported Peagarikano O , et al. (2011)
Social behavior Juvenile play Decreased Reciprocal social interaction test P21 Peagarikano O , et al. (2011)
Physiological parameters NA Not reported NA NA -
Physiological parameters Digestive system function: gastrointestinal motility: peristaltic reflexes Decreased In vitro analysis of colonic migrating motor complexes (CMMCs) 9 weeks -
Physiological parameters Digestive system function: gastrointestinal motility: colonic motility Increased Measurement of colonic motility 9 weeks -
Physiological parameters Digestive system function: gastrointestinal motility: colonic motility Increased In vitro analysis of colonic migrating motor complexes (CMMCs) 9 weeks -
Physiological parameters Digestive system function: gastrointestinal motility Decreased Intestinal transit time 9 weeks -
Physiological parameters Digestive system function: fecal composition No change Fecal pellet measurements 9 weeks -
Physiological parameters NA Not reported NA NA ()
Physiological parameters NA Not reported NA NA Antoine MW , et al. (2019)
Physiological parameters NA Not reported NA NA Gao R , et al. (2018)
Physiological parameters NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Physiological parameters NA Not reported NA NA Schaafsma SM , et al. (2017)
Physiological parameters NA Not reported NA NA Thomas AM , et al. (2016)
Physiological parameters Core body temperature No change Body temperature measurement 4, 8 months Thomas AM , et al. (2016)
Physiological parameters NA Not reported NA NA Brunner D , et al. (2015)
Physiological parameters Core body temperature No change Body weight measurement P4, p7, p15 Brunner D , et al. (2015)
Physiological parameters NA Not reported NA NA Kloth AD , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2011)
Communications NA Not reported NA NA -
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations P5 Tai C et al. (2020)
Communications NA Not reported NA NA ()
Communications NA Not reported NA NA Antoine MW , et al. (2019)
Communications NA Not reported NA NA Gao R , et al. (2018)
Communications NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations P3 Schaafsma SM , et al. (2017)
Communications NA Not reported NA NA Thomas AM , et al. (2016)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P4, p7, p15 Brunner D , et al. (2015)
Communications Ultrasonic vocalization: interaction induced: opposite sex stimulus Decreased Scent marking test Adult Brunner D , et al. (2015)
Communications NA Not reported NA NA Kloth AD , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations P3-p12 Peagarikano O , et al. (2011)
Developmental profile Size/growth No change Body weight measurement 9 weeks -
Developmental profile NA Not reported NA NA -
Developmental profile Digestive system morphology: GI tract wall No change Histology 11 weeks -
Developmental profile Digestive system morphology: GI tract length No change Gross necroscopy 11 weeks -
Developmental profile NA Not reported NA NA ()
Developmental profile NA Not reported NA NA Antoine MW , et al. (2019)
Developmental profile NA Not reported NA NA Gao R , et al. (2018)
Developmental profile NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Developmental profile NA Not reported NA NA Schaafsma SM , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 7-13 weeks Thomas AM , et al. (2016)
Developmental profile Size/growth Decreased General observations P4, p7, p15, 1 month, 2 months, 2.7 months, 3 months Brunner D , et al. (2015)
Developmental profile Developmental trajectory Increased Developmental milestone measurements P4 Brunner D , et al. (2015)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P13 Brunner D , et al. (2015)
Developmental profile Developmental trajectory Increased Negative geotaxis test P15 Brunner D , et al. (2015)
Developmental profile NA Not reported NA NA Kloth AD , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile Size/growth No change General observations Unreported Peagarikano O , et al. (2011)
Developmental profile General characteristics No change General observations Unreported Peagarikano O , et al. (2011)
Emotion NA Not reported NA NA -
Emotion Anxiety Increased Elevated plus maze test unreported Tripathi MK et al. (2023)
Emotion Exploratory activity No change Textured novel object recognition test (T-NORT) 3-6 months Balasco L et al. (2022)
Emotion Anxiety No change Open field test 3-6 months Balasco L et al. (2022)
Emotion Anxiety No change Open field test 7-11 months Tai C et al. (2020)
Emotion Anxiety No change Elevated plus maze 7-11 months Tai C et al. (2020)
Emotion NA Not reported NA NA ()
Emotion NA Not reported NA NA Antoine MW , et al. (2019)
Emotion NA Not reported NA NA Gao R , et al. (2018)
Emotion NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Emotion Anxiety Decreased Open field test P40 Schaafsma SM , et al. (2017)
Emotion Exploratory activity Increased Open field test 8-9 weeks Thomas AM , et al. (2016)
Emotion Exploratory activity Decreased Three-chamber social approach test 2 months Brunner D , et al. (2015)
Emotion Anxiety No change Marble-burying test 2 months Brunner D , et al. (2015)
Emotion NA Not reported NA NA Kloth AD , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion Anxiety No change Light-dark exploration test Unreported Peagarikano O , et al. (2011)
Immune response NA Not reported NA NA -
Immune response NA Not reported NA NA ()
Immune response NA Not reported NA NA Antoine MW , et al. (2019)
Immune response NA Not reported NA NA Gao R , et al. (2018)
Immune response NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Immune response NA Not reported NA NA Schaafsma SM , et al. (2017)
Immune response NA Not reported NA NA Thomas AM , et al. (2016)
Immune response NA Not reported NA NA Brunner D , et al. (2015)
Immune response NA Not reported NA NA Kloth AD , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response Astrogliosis Increased Western blot 6 months Peagarikano O , et al. (2011)
Learning & memory NA Not reported NA NA -
Learning & memory Spatial working memory Decreased T-maze test 7 weeks et al. ()
Learning & memory Object recognition memory Decreased Novel object recognition test unreported Tripathi MK et al. (2023)
Learning & memory Olfactory learning and memory No change Olfactory habituation-dishabituation test 7-11 months Tai C et al. (2020)
Learning & memory Cognitive flexibility No change Water t-maze test 7-11 months Tai C et al. (2020)
Learning & memory NA Not reported NA NA ()
Learning & memory NA Not reported NA NA Antoine MW , et al. (2019)
Learning & memory NA Not reported NA NA Gao R , et al. (2018)
Learning & memory NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Learning & memory NA Not reported NA NA Schaafsma SM , et al. (2017)
Learning & memory NA Not reported NA NA Thomas AM , et al. (2016)
Learning & memory Spatial working memory Increased Water t-maze test 2 months Brunner D , et al. (2015)
Learning & memory Cognitive flexibility No change Water t-maze test 2 months Brunner D , et al. (2015)
Learning & memory Spatial learning No change Water y-maze test 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning: extinction and reactivation No change Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning No change Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning Decreased Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory Spatial learning No change Morris water maze test Unreported Peagarikano O , et al. (2011)
Learning & memory Object recognition memory No change General observations Unreported Peagarikano O , et al. (2011)
Learning & memory Cognitive flexibility Decreased Morris water maze test Unreported Peagarikano O , et al. (2011)
Maternal behavior NA Not reported NA NA -
Maternal behavior NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA Antoine MW , et al. (2019)
Maternal behavior NA Not reported NA NA Gao R , et al. (2018)
Maternal behavior NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Maternal behavior NA Not reported NA NA Schaafsma SM , et al. (2017)
Maternal behavior NA Not reported NA NA Thomas AM , et al. (2016)
Maternal behavior Maternal nurturing No change General observations P4, p7 Brunner D , et al. (2015)
Maternal behavior NA Not reported NA NA Kloth AD , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2011)
Molecular profile NA Not reported NA NA -
Molecular profile Targeted expression Decreased Western blot unreported Tripathi MK et al. (2023)
Molecular profile Signaling: PKA pathway No change Cyclic nucleotide activity assay unreported Tripathi MK et al. (2023)
Molecular profile Signaling: nitric oxide pathway Increased Griess reagent assay unreported Tripathi MK et al. (2023)
Molecular profile Signaling: nitric oxide pathway Increased Cyclic nucleotide activity assay unreported Tripathi MK et al. (2023)
Molecular profile Signaling: pi3k/akt pathway Increased Western blot 6-7 months Tai C et al. (2020)
Molecular profile Signaling: mtor pathway Increased Western blot 6-7 months Tai C et al. (2020)
Molecular profile NA Not reported NA NA ()
Molecular profile NA Not reported NA NA Antoine MW , et al. (2019)
Molecular profile Targeted expression Decreased Western blot 5 months Gao R , et al. (2018)
Molecular profile Protein localization: membrane Decreased Western blot 5 months Gao R , et al. (2018)
Molecular profile Protein expression level evidence No change Western blot 5 months Gao R , et al. (2018)
Molecular profile NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Molecular profile Chromatin modification Decreased Quantitative pcr (qrt-pcr) P40 Schaafsma SM , et al. (2017)
Molecular profile NA Not reported NA NA Thomas AM , et al. (2016)
Molecular profile NA Not reported NA NA Brunner D , et al. (2015)
Molecular profile NA Not reported NA NA Kloth AD , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2011)

M_CNTNAP2_5_KO_HM_7-NITROINDAZOLE

Model Type: RESCUE-Pharmacological
Model Genotype: Homozygous

Mutation:

Cntnap2 knockout (MGI:2677631) mice were treated with neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI), for 10 consecutive days. The pharmacological interventions were performed by daily intraperitoneal (IP) injection at a dose of 80 mg/kg.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: 37212048
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Category Signaling: nitric oxide pathway Restored Griess reagent assay unreported Tripathi MK et al. (2023)
Category Signaling: nitric oxide pathway Restored Cyclic nucleotide activity assay unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Ameliorated Western blot unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: inhibitory neurons Ameliorated Immunofluorescence staining unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: excitatory neurons Ameliorated Immunofluorescence staining unreported Tripathi MK et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Ameliorated Golgi-Cox staining unreported Tripathi MK et al. (2023)
Neurophysiology Oxidative stress in neurons Ameliorated Western blot unreported Tripathi MK et al. (2023)
Social behavior Social approach Restored Three-chamber social approach test unreported Tripathi MK et al. (2023)
Emotion Anxiety Restored Elevated plus maze test unreported Tripathi MK et al. (2023)
Learning & memory Object recognition memory Restored Novel object recognition test unreported Tripathi MK et al. (2023)
Molecular profile Signaling: PKA pathway No adverse effect Cyclic nucleotide activity assay unreported Tripathi MK et al. (2023)
Molecular profile Signaling: nitric oxide pathway Restored Griess reagent assay unreported Tripathi MK et al. (2023)
Molecular profile Signaling: nitric oxide pathway Restored Cyclic nucleotide activity assay unreported Tripathi MK et al. (2023)

M_CNTNAP2_5_KO_HM_AVP-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of arginine vasopressin, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test 6-8 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_AVP-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered arginine vasopressin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_AVP-OXTR-ANT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered with oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by AVP at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_AVPR-ANT_AVP

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered arginine vasopressin receptor (AVP-V1a receptor)antagonist (reclovaptan) intranasally at a dose of 300ug/kg, followed by AVP at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_BH4

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Tetrahydrobiopterin dihydrochloride (bh4) was administered via oral gavage at a dose of 20 mg/kg for 2-4 weeks and 2 hours prior to behavior tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J 

Es cell line: R1
Model Source: C57BL/6J
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Motor phenotype General locomotor activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission Restored Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social interaction Restored Reciprocal social interaction test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social approach Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_C79

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Cntnap2 mice with two knockout alleles (MGI:2677631) were injected in the medial prefrontal cortex at the age of 3 weeks with the adeno-associated virus (AAV) vector expressing CNTNAP2-C79 protein (AAV-C79) and AAV-EGFP (as the control). C79 is the C-terminal peptide resulting from CNTNAP2 cleavage by alpha-secretase ADAM10.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Elior Peles
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Social behavior Social interaction Restored Reciprocal social interaction test 7 weeks et al. ()
Social behavior Social approach Restored Three-chamber social approach test 7 weeks et al. ()
Learning & memory Spatial working memory Restored T-maze test 7 weeks et al. ()

M_CNTNAP2_5_KO_HM_COCAINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of cntnap2 gene with an oppositely directed neo gene identical to model m_cntnap2_5_ko_hm. control wt c57bl/6j (stock #000664) and cntnap2 ko hm (cntnap2tm1pele, stock # 017482) (poliak et al., 2003) were obtained from jackson

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: C57BL/6J
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neurophysiology Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission Restored Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_COHOUSING

Model Type: RESCUE-Behavioral
Model Genotype: Homozygous

Mutation:

Cntnap2 ko mutant mice originated from the isolated line were cohoused with isolated wt mice which allows the passive interchange of gut microbiota between hosts, to test the hypothesis that the social phenotype is driven by the gut microbiome and not the genetic mutation

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J 

Es cell line: R1
Model Source: C57BL/6J
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Motor phenotype General locomotor activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social interaction Restored Reciprocal social interaction test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social approach Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Physiological parameters Intestinal microbiota composition Restored 16S rRNA gene sequence analysis for identification of bacteria 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_DREADD-OXTN

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Using the Designer Receptor Exclusively Activated by Designer Drug(s) (DREADD) approach a modified muscarinic receptor tagged with marker mCherry (hM3Dq-mCherry), exclusively activated by the otherwise inert ligand- clozepine N-oxide (CNO), was expressed in the oxytocin cells of the paraventricular nuclei of the hypothalamus, in Cntnap2 KO mice and wild type controls, by means of stereotaxic injection of an AAV2 virus carrying the hM3Dg-mcherry construct. The expression of hM3Dq-mCherry was restricted to oxytocin cells by driving the expression under promotor for oxytocin. CNO was administered intraperitoneally at 5mg/kg, 30 min before testing.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test NA Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_FENOBAM

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of Fenobam, which is a mGlur5 agonist, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_FLUMAZENIL

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of Flumazenil, which is a benzodiazepine receptor agonist , or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_FLUOXETINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.) of Fluoxetine, which is an serotonin reuptake inhibitor, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_GUT

Model Type: Multifactorial
Model Genotype: Homozygous

Mutation:

Gene targeted replacement of exon 1 of cntnap2 gene with an oppositely directed neo gene identical to model m_cntnap2_5_ko_hm. control wt c57bl/6j (stock #000664) and cntnap2 ko hm (cntnap2tm1pele, stock # 017482) (poliak et al., 2003) were obtained from jackson

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: C57BL/6J
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Increased Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Motor phenotype General locomotor activity Increased Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Oxytocin expressing Decreased Immunofluorescence staining 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission Decreased Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Miniature post synaptic current amplitude: excitatory Decreased Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Sensory Olfaction No change Buried food test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Decreased Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social interaction Decreased Reciprocal social interaction test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social approach Decreased Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Physiological parameters Intestinal microbiota composition Abnormal 16S rRNA gene sequence analysis for identification of bacteria 7-12 weeks Buffington SA et al. (2021)
Physiological parameters Intestinal microbiota composition Decreased Quantitative PCR (qRT-PCR) 7-12 weeks Buffington SA et al. (2021)
Molecular profile Metabolite level quantification Abnormal Liquid chromatography-mass spectrometry (LC-MS) 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_HET_BREEDING

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Cntnap2 ko and wt mice were generated by breeding cntnap2 ht ko mice derived by crossing cntnap2 ko hm and wt (c57bl/6j) mice obtained from jackson laboratories isolated lines to ensure intermingling of intestinal microbiota.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J 

Es cell line: R1
Model Source: C57BL/6J 
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Motor phenotype General locomotor activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social interaction Restored Reciprocal social interaction test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social approach Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Physiological parameters Intestinal microbiota composition Restored 16S rRNA gene sequence analysis for identification of bacteria 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_IL17A-S1DZ

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Recombinant IL17a protein (50 ng per side in 1 microliter at a rate of 180 nl/min, 7956-ML/CF, R&D) was administered directly and bilaterally into the primary somatosensory cortex dysgranular zone in adult male Cntnap2 mutant four hours before testing.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neurophysiology NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social approach Restored Three-chamber social approach test Adult ()
Physiological parameters NA Not reported NA NA ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion NA Not reported NA NA ()
Immune response NA Not reported NA NA ()
Learning & memory NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_CNTNAP2_5_KO_HM_LPS

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 homozygous mutants were treated with lipopolysaccharide (50microgram/kg, i.p., acute)

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neurophysiology Neuronal activation Refractory Immunohistochemistry Adult ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social approach Refractory Three-chamber social approach test Adult ()
Physiological parameters NA Not reported NA NA ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion NA Not reported NA NA ()
Immune response Cytokine levels: pro-inflammatory Side effect Elisa Adult, 2-5 months, 9-12 months ()
Learning & memory NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_CNTNAP2_5_KO_HM_LREUTERI

Model Type: RESCUE-Dietary
Model Genotype: Homozygous

Mutation:

L. reuteri was added to the drinking water daily to minimize dosage variability. the experimental group received live bacteria (approximately 10^8 organisms/mouse/day), while the control group received equal volume of pbs. mice drank the treated water ad libitum during the treatment period. fecal sample collection, behavioral assays, tissue collection and electrophysiological recordings were initiated 4 weeks after the beginning of the treatment period.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J 

Es cell line: R1
Model Source: C57BL/6J 
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Refractory Three-chamber social approach test 7-12 weeks, Adult Buffington SA et al. (2021)
Motor phenotype General locomotor activity Refractory Three-chamber social approach test 7-12 weeks, Adult Buffington SA et al. (2021)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Oxytocin expressing Restored Immunofluorescence staining 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission Restored Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Miniature post synaptic current frequency: excitatory Refractory Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Neurophysiology Miniature post synaptic current amplitude: excitatory Refractory Whole-cell voltage clamp 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Restored Three-chamber social approach test 7-12 weeks, Adult Buffington SA et al. (2021)
Social behavior Social interaction Restored Reciprocal social interaction test 7-12 weeks, Adult Buffington SA et al. (2021)
Social behavior Social approach Restored Three-chamber social approach test 7-12 weeks, Adult Buffington SA et al. (2021)
Molecular profile Metabolite level quantification Ameliorates Liquid chromatography-mass spectrometry (LC-MS) 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_MC4R-AG

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered MC4R agonist at 7.5 mg/kg (i.p.) 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_MC4R-AG-OXTR-ANT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered OXTR antagonist (L371,257) intranasally at 300ug/kg, followed by MC4R agonist at 7.5 mg/kg (i.p.), followed by 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXT-OXTR-ANT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered an oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by oxytocin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXTR-ANT_AVP

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered with oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by AVP at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXTR-ANT_MC4R-AG

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered OXTR antagonist (L371,257) intranasally at 300ug/kg, followed by MC4R agonist at 7.5 mg/kg (i.p.), followed by 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXTR-ANT_OXT

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered an oxytocin receptor antagonist (L371,257) intranasally at a dose of 300ug/kg, followed by oxytocin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Refractory Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXYTOCIN

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Oxytocin was administrated intranasally at a dose of 200 mg/kg 30 minutes prior to social behavior testing, since the effects of oxytocin last 2 hours with this delivery method.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J 

Es cell line: R1
Model Source: C57BL/6J 
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Motor phenotype General locomotor activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social interaction Restored Reciprocal social interaction test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social approach Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_5_KO_HM_OXYTOCIN-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were acutely treated with 10 mg/kg (i.p.)of oxytocin, or vehicle (10%DMSO in PBS) of 20-30 minutes before testing in social behavioral paradigm(s).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test 6-8 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXYTOCIN-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO (equal male:female ratio) juvenile (4-6 wks old) mice were administered oxytocin at ~ 200ug/kg or saline intranasally 20-30 min before testing in social behavioral tests.A group of these animals were also tested a 1-9 hrs after drug administration.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype Hyperactivity Refractory Open field test 4-6 weeks Peagarikano O , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2015)
Repetitive behavior Self grooming: perseveration Refractory Grooming behavior assessments 4-6 weeks Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory Pain or nociception Refractory Hot plate test 4-6 weeks Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4-6 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory Spatial working memory Refractory T-maze test 4-6 weeks Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_OXYTOCIN-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO pups were treated with a daily administration of oxytocin at ~ 200ug/kg or saline intranasally between {P7- P21 and tested at P30.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2015)
Motor phenotype NA Not reported NA NA Peagarikano O , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: oxytocin expressing Ameliorated Immunohistochemistry 4 weeks Peagarikano O , et al. (2015)
Neurophysiology Neurotransmitter release: neurohypophysial Ameliorated Radioimmunoassay (ria) 4 weeks Peagarikano O , et al. (2015)
Repetitive behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2015)
Sensory NA Not reported NA NA Peagarikano O , et al. (2015)
Social behavior Social interaction Restored Reciprocal social interaction test 4 weeks Peagarikano O , et al. (2015)
Social behavior Social approach Restored Three-chamber social approach test 4 weeks Peagarikano O , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2015)
Communications NA Not reported NA NA Peagarikano O , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2015)
Learning & memory NA Not reported NA NA Peagarikano O , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2015)

M_CNTNAP2_5_KO_HM_PV

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Cntnap2 null mutant mice with a temporally precise reduction in E:I balance in the medial prefrontal cortex (mPFC) generated by optogenetically increasing the excitability of inhibitory parvalbumin (PV) neurons in a real-time and reversible manner. PV:Cre homozygous mice were bred with cntnap2 KO male mice for several generations to obtain PV:Cre homozygous, Cntnap2 wildtype, heterozygous and null mice. AAV5-EF1a::DIO-SSFO-eYFP was injected into the medial prefrontal cortex to selectively express the microbial stabilized step-function opsin (SSFO) in mouse parvalbumin neurons. Activation of SSFO in PV neurons by a single pulse of blue light (2 second light pulse of wavelength 473 nm) resulted in the neurons requiring lower inward-current amplitudes to generate action potentials. This indicated SSFO activation increased the excitability of the inhibitory PV neurons.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Motor phenotype Spontaneous movement Restored Open field test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Restored Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Neurophysiology Neuronal activation Ameliorated Fiber photometry Adult Selimbeyoglu A , et al. (2017)
Repetitive behavior NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Seizure NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Sensory NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Social behavior Social interaction Restored Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Social behavior Inanimate object preference Ameliorated Novel object recognition test Adult Selimbeyoglu A , et al. (2017)
Physiological parameters NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Communications NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Developmental profile NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Emotion NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Immune response NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Learning & memory NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Maternal behavior NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Molecular profile NA Not reported NA NA Selimbeyoglu A , et al. (2017)

M_CNTNAP2_5_KO_HM_PY

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Cntnap2 null mutant mice with a temporally precise reduction in E:I balance in the medial prefrontal cortex (mPFC) by optogenetically decreasing the excitability of excitatory pyramidal neurons in a real-time and reversible manner. SwiChR++, a blue lightactivated bistable chloride channel, was selectively expressed in excitatory pyramidal neurons by injection of AAV8-CKIIa-SwiChR++-eYFP into the medial prefrontal cortex.1 second pulses of 473-nm wavelength light at 1-min intervals were used to activate SwiChR++.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Motor phenotype Spontaneous movement Restored Open field test Adult Selimbeyoglu A , et al. (2017)
Motor phenotype General locomotor activity Restored Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Neurophysiology NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Repetitive behavior NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Seizure NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Sensory NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Social behavior Social interaction Ameliorated Reciprocal social interaction test Adult Selimbeyoglu A , et al. (2017)
Social behavior Inanimate object preference Ameliorated Novel object recognition test Adult Selimbeyoglu A , et al. (2017)
Physiological parameters NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Communications NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Developmental profile NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Emotion NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Immune response NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Learning & memory NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Maternal behavior NA Not reported NA NA Selimbeyoglu A , et al. (2017)
Molecular profile NA Not reported NA NA Selimbeyoglu A , et al. (2017)

M_CNTNAP2_5_KO_HM_RISPERIDONE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Cntnap2 KO mice were treated with risperidone or vehicle for 7-10 days.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2011)
Motor phenotype General locomotor activity Restored Open field test NA Peagarikano O , et al. (2011)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2011)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2011)
Repetitive behavior Perseveration Restored T-maze test NA Peagarikano O , et al. (2011)
Seizure NA Not reported NA NA Peagarikano O , et al. (2011)
Sensory Pain or nociception Refractory Hot plate test NA Peagarikano O , et al. (2011)
Social behavior Social interaction Refractory Three-chamber social approach test Unreported Peagarikano O , et al. (2011)
Social behavior Nest building behavior Restored General observations NA Peagarikano O , et al. (2011)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2011)
Communications NA Not reported NA NA Peagarikano O , et al. (2011)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2011)
Emotion NA Not reported NA NA Peagarikano O , et al. (2011)
Immune response NA Not reported NA NA Peagarikano O , et al. (2011)
Learning & memory Object recognition memory Restored General observations Unreported Peagarikano O , et al. (2011)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2011)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2011)

M_CNTNAP2_5_KO_HM_S1DZ-INACT

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Neural activity was optogenetically suppressed in the primary somatosensory cortex dysgranular zone in Cntnap2 mutant mice. Control mice express enhanced yellow fluorescent protein (EYFP).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neurophysiology NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social approach Restored Three-chamber social approach test Adult ()
Physiological parameters NA Not reported NA NA ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion NA Not reported NA NA ()
Immune response NA Not reported NA NA ()
Learning & memory NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_CNTNAP2_5_KO_HM_TAU-DEF-1

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Cntnap2 null mice (M_CNTNAP2_5_KO_HM) and controls were crossed onto heterozygous MAPT (rescue) backgrounds (Gheyara et al., 2014) that impart 50% brain tau levels compared to Mapt wildtype controls.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Restored Measurement of tissue weight 9-10 months Tai C et al. (2020)
Repetitive behavior Self grooming: perseveration Restored Novel cage test 3-4 months Tai C et al. (2020)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Restored Electroencephalogram (eeg) 7-11 months Tai C et al. (2020)
Social behavior Nest building behavior Restored Nest building assay 7-11 months Tai C et al. (2020)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P5 Tai C et al. (2020)

M_CNTNAP2_5_KO_HM_TAU-DEF-2

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Cntnap2 null mice (M_CNTNAP2_5_KO_HM) and controls were crossed onto null MAPT (rescue) backgrounds (Gheyara et al., 2014) that impart 0% brain tau levels compared to Mapt wildtype controls.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Restored Measurement of tissue weight 9-10 months Tai C et al. (2020)
Repetitive behavior Self grooming: perseveration Restored Novel cage test 3-4 months Tai C et al. (2020)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Restored Electroencephalogram (eeg) 7-11 months Tai C et al. (2020)
Social behavior Social scent marking or recognition Restored Olfactory habituation-dishabituation test 7-11 months Tai C et al. (2020)
Social behavior Nest building behavior Restored Nest building assay 7-11 months Tai C et al. (2020)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P5 Tai C et al. (2020)
Learning & memory Olfactory learning and memory No adverse effect Olfactory habituation-dishabituation test 7-11 months Tai C et al. (2020)
Molecular profile Signaling: pi3k/akt pathway Restored Western blot 6-7 months Tai C et al. (2020)
Molecular profile Signaling: mtor pathway Restored Western blot 6-7 months Tai C et al. (2020)

M_CNTNAP2_5_KO_HM_WT-LITTER-SEPARATION

Model Type: RESCUE-Behavioral
Model Genotype: Homozygous

Mutation:

Cntnap2 ko mutant mice originated from the littermate line were separated from wildtype littermates to test the hypothesis that the social phenotype is driven by the gut microbiome and not the genetic mutation. to accomplish this wt and ko littermate mice were separated according to their genotype at weaning and bred as adults to generate transgenerational wt and ko mice (wt-t and ko-t)

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J 

Es cell line: R1
Model Source: C57BL/6J 
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity: Ambulatory activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Motor phenotype General locomotor activity Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social memory Refractory Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social interaction Refractory Reciprocal social interaction test 7-12 weeks Buffington SA et al. (2021)
Social behavior Social approach Restored Three-chamber social approach test 7-12 weeks Buffington SA et al. (2021)
Physiological parameters Intestinal microbiota composition Refractory 16S rRNA gene sequence analysis for identification of bacteria 7-12 weeks Buffington SA et al. (2021)

M_CNTNAP2_6_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Targeted replacement of exon 1 of Cntnap2 gene maintained as a heterozygous.

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA -
Circadian sleep/wake cycle NA Not reported NA NA Antoine MW , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Kloth AD , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Peagarikano O , et al. (2011)
Motor phenotype NA Not reported NA NA -
Motor phenotype NA Not reported NA NA Antoine MW , et al. (2019)
Motor phenotype NA Not reported NA NA Kloth AD , et al. (2015)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test NA Peagarikano O , et al. (2011)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test NA Peagarikano O , et al. (2011)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA -
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Antoine MW , et al. (2019)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Kloth AD , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Peagarikano O , et al. (2011)
Neurophysiology Neuronal activation No change Whole-cell voltage clamp P17-p23 -
Neurophysiology Synaptic transmission Increased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Stimulus-spike relationship: inhibitory Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Network excitability No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Network excitability No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Membrane potential No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Intrinsic membrane properties No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Epsp-spike relationship Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: rate of depolarization No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate Increased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate Increased Cell-attached patch clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: amplitude No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology NA Not reported NA NA Kloth AD , et al. (2015)
Neurophysiology NA Not reported NA NA Peagarikano O , et al. (2011)
Repetitive behavior NA Not reported NA NA -
Repetitive behavior NA Not reported NA NA Antoine MW , et al. (2019)
Repetitive behavior NA Not reported NA NA Kloth AD , et al. (2015)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments NA Peagarikano O , et al. (2011)
Seizure NA Not reported NA NA -
Seizure NA Not reported NA NA Antoine MW , et al. (2019)
Seizure NA Not reported NA NA Kloth AD , et al. (2015)
Seizure NA Not reported NA NA Peagarikano O , et al. (2011)
Sensory Sensory-evoked response: excitation: tactile stimulus Decreased Whole-cell voltage clamp P42-p92 -
Sensory NA Not reported NA NA -
Sensory NA Not reported NA NA Antoine MW , et al. (2019)
Sensory NA Not reported NA NA Kloth AD , et al. (2015)
Sensory Pain or nociception No change Hot plate test NA Peagarikano O , et al. (2011)
Social behavior NA Not reported NA NA -
Social behavior NA Not reported NA NA Antoine MW , et al. (2019)
Social behavior NA Not reported NA NA Kloth AD , et al. (2015)
Social behavior Social approach No change Three-chamber social approach test NA Peagarikano O , et al. (2011)
Physiological parameters NA Not reported NA NA -
Physiological parameters NA Not reported NA NA Antoine MW , et al. (2019)
Physiological parameters NA Not reported NA NA Kloth AD , et al. (2015)
Physiological parameters NA Not reported NA NA Peagarikano O , et al. (2011)
Communications NA Not reported NA NA -
Communications NA Not reported NA NA Antoine MW , et al. (2019)
Communications NA Not reported NA NA Kloth AD , et al. (2015)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P3,p6,p9,p12 Peagarikano O , et al. (2011)
Developmental profile NA Not reported NA NA -
Developmental profile NA Not reported NA NA Antoine MW , et al. (2019)
Developmental profile NA Not reported NA NA Kloth AD , et al. (2015)
Developmental profile NA Not reported NA NA Peagarikano O , et al. (2011)
Emotion NA Not reported NA NA -
Emotion NA Not reported NA NA Antoine MW , et al. (2019)
Emotion NA Not reported NA NA Kloth AD , et al. (2015)
Emotion NA Not reported NA NA Peagarikano O , et al. (2011)
Immune response NA Not reported NA NA -
Immune response NA Not reported NA NA Antoine MW , et al. (2019)
Immune response NA Not reported NA NA Kloth AD , et al. (2015)
Immune response NA Not reported NA NA Peagarikano O , et al. (2011)
Learning & memory NA Not reported NA NA -
Learning & memory NA Not reported NA NA Antoine MW , et al. (2019)
Learning & memory Eye blink conditioning: extinction and reactivation No change Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory Eye blink conditioning No change Eyeblink conditioning 2-4 months Kloth AD , et al. (2015)
Learning & memory Spatial working memory No change T-maze test NA Peagarikano O , et al. (2011)
Learning & memory Spatial learning No change Morris water maze test NA Peagarikano O , et al. (2011)
Learning & memory Cognitive flexibility No change Morris water maze test NA Peagarikano O , et al. (2011)
Maternal behavior NA Not reported NA NA -
Maternal behavior NA Not reported NA NA Antoine MW , et al. (2019)
Maternal behavior NA Not reported NA NA Kloth AD , et al. (2015)
Maternal behavior NA Not reported NA NA Peagarikano O , et al. (2011)
Molecular profile NA Not reported NA NA -
Molecular profile NA Not reported NA NA Antoine MW , et al. (2019)
Molecular profile NA Not reported NA NA Kloth AD , et al. (2015)
Molecular profile NA Not reported NA NA Peagarikano O , et al. (2011)

M_CNTNAP2_7_KO_HM_LPS

Model Type: Multifactorial
Model Genotype: Homozygous

Mutation:

Homozygous Cntnap2 KO mice are obtained by crossing heterozygous Cntnap2 KO mice and subjecting the pregnant females to a MIA at gestational day GD7 (0.30 mg/kg LPS in saline by subcutaneous injections).

Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J

Es cell line: R1
Model Source: Peles lab
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Schaafsma SM , et al. (2017)
Motor phenotype General locomotor activity Increased Open field test P40 Schaafsma SM , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: crh No change Quantitative pcr (qrt-pcr) P40 Schaafsma SM , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: crh Decreased Quantitative pcr (qrt-pcr) P40 Schaafsma SM , et al. (2017)
Neurophysiology NA Not reported NA NA Schaafsma SM , et al. (2017)
Repetitive behavior NA Not reported NA NA Schaafsma SM , et al. (2017)
Seizure NA Not reported NA NA Schaafsma SM , et al. (2017)
Sensory NA Not reported NA NA Schaafsma SM , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Social behavior Social dishabituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Physiological parameters NA Not reported NA NA Schaafsma SM , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations P3 Schaafsma SM , et al. (2017)
Developmental profile NA Not reported NA NA Schaafsma SM , et al. (2017)
Emotion Anxiety No change Open field test P40 Schaafsma SM , et al. (2017)
Immune response NA Not reported NA NA Schaafsma SM , et al. (2017)
Learning & memory NA Not reported NA NA Schaafsma SM , et al. (2017)
Maternal behavior NA Not reported NA NA Schaafsma SM , et al. (2017)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) P40 Schaafsma SM , et al. (2017)
Molecular profile Chromatin modification No change Quantitative pcr (qrt-pcr) P40 Schaafsma SM , et al. (2017)
Molecular profile Chromatin modification Decreased Quantitative pcr (qrt-pcr) P40 Schaafsma SM , et al. (2017)

M_CNTNAP2_9_KO_HM_MIA

Model Type: Multifactorial
Model Genotype: Homozygous

Mutation:

Homozygous Cntnap2 KO mice are obtained by crossing heterozygous Cntnap2 KO mice and subjecting the pregnant females to a MIA at gestational day GD7 (0.30 mg/kg LPS in saline by subcutaneous injections).

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Schaafsma SM , et al. (2017)
Motor phenotype NA Not reported NA NA Schaafsma SM , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Schaafsma SM , et al. (2017)
Neurophysiology NA Not reported NA NA Schaafsma SM , et al. (2017)
Repetitive behavior NA Not reported NA NA Schaafsma SM , et al. (2017)
Seizure NA Not reported NA NA Schaafsma SM , et al. (2017)
Sensory NA Not reported NA NA Schaafsma SM , et al. (2017)
Social behavior Social habituation Decreased Social recognition test 6 weeks Schaafsma SM , et al. (2017)
Physiological parameters NA Not reported NA NA Schaafsma SM , et al. (2017)
Communications NA Not reported NA NA Schaafsma SM , et al. (2017)
Developmental profile NA Not reported NA NA Schaafsma SM , et al. (2017)
Emotion NA Not reported NA NA Schaafsma SM , et al. (2017)
Immune response NA Not reported NA NA Schaafsma SM , et al. (2017)
Learning & memory NA Not reported NA NA Schaafsma SM , et al. (2017)
Maternal behavior NA Not reported NA NA Schaafsma SM , et al. (2017)
Molecular profile NA Not reported NA NA Schaafsma SM , et al. (2017)
Other CNTNAP2 Rescue Models(34 Models)
Sort By:
M_CNTNAP2_2_KO_HM 1 Genetic Genetic Human CNTNAP2
M_CNTNAP2_5_KO_HM 1 Genetic Pharmacological 7-nitroindazole
M_CNTNAP2_5_KO_HM 3 Genetic Pharmaceutical Arginine vasopressin
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Arginine vasopressin;L371,257
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Arginine vasopressin;Relcovaptan
M_CNTNAP2_5_KO_HM 1 Genetic Genetic C79 gene fragment
M_CNTNAP2_5_KO_HM 1 Genetic Genetic DREADD-Oxytocin neurons
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Fenobam
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Flumazenil
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Fluoxetine
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Recombinant interleukin 17a
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Lipopolysaccharide
M_CNTNAP2_5_KO_HM 2 Genetic Pharmaceutical Ro27-3225
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Ro27-3225;L371,257
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Oxytocin;L371,257
M_CNTNAP2_5_KO_HM 4 Genetic Pharmaceutical Oxytocin
M_CNTNAP2_5_KO_HM 1 Genetic Procedural Parvalbumin neuron activation
M_CNTNAP2_5_KO_HM 1 Genetic Procedural Pyramidal neuron activation
M_CNTNAP2_5_KO_HM 1 Genetic Pharmaceutical Risperidone
M_CNTNAP2_5_KO_HM 1 Genetic Procedural Primary somatosensory cortex dysgranular zone (S1DZ) optogenetic inactivation
M_CNTNAP2_5_KO_HM 2 Genetic Genetic Tau deficiency
M_CNTNAP2_10_KI_HT 1 Genetic Pharmaceutical Isoguvacine
M_CNTNAP2_11_KD 1 Genetic LOF Pharmaceutical CX-546
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Pharmaceutical Tetrahydrobiopterin
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Pharmaceutical Cocaine
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Behavioral Cohousing
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Procedural Heterozygous breeding
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Dietary Lactobacillus reuteri
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Pharmaceutical Oxytocin
M_CNTNAP2_5_KO_HM_GUT 1 Multifactorial Behavioral Separation from wildtype littermate
M_CNTNAP2_11_KO_HM 1 Genetic Genetic AAV1-Ef1a-DIO ChETA-EYFP
M_CNTNAP2_11_KO_HM 1 Genetic Pharmaceutical Oxytocin
M_CNTNAP2_11_KO_HM 1 Genetic Pharmaceutical OXTR agonist TGOT
M_CNTNAP2_12_KI_HT_I1253T 1 Genetic Genetic C79 gene fragment
CNVs associated with CNTNAP2(1 Models)
Sort By:
7q35-q36.1 5 Deletion-Duplication 8  /  6
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