Genetic Mouse Models / DLGAP1

DLGAP1 DLG associated protein 1

Model Species
Mus musculus
Gene Aliases
4933422O14Rik, 9630002F18, AI845682, AI848168, BB075781, D17Bwg0511e, GKAP/SAPAP, GKPA/SAPAP, Gkap, Sapap1, mKIAA4162
Reports
2
Associated Human Genes
DLGAP1
Models / Rescue Models
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Rescue Model
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Model Summary

Dlgap1 KO mice showed disrupted protein interactions in the postsynaptic density, and deficits in sociability. Ambulation, rearing, anxiety, depression, locomotion, startle response and nest building were largely unaffected. Induced grooming and exploration activity were decreased (Coba MP, et al, Sci. Rep., 2018).

Reports related to DLGAP1 (2 Reports)
# Type Title Author, Year
1 Primary Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. Coba MP , et al. (2018)
2 additional Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2 Horner AE et al. (2021)
Show all Construct Details Show all Phenotypic Profiles

M_DLGAP1_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Mice harboring a homozygous null mutation of the DLGAP1 allele. (No other information reported). .

Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129*C57BL/6 J

Es cell line: Not reported
Model Source: Dr. Seth Grant at Edinburgh University.
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Coba MP , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Coba MP , et al. (2018)
Motor phenotype Self grooming: artificial stress evoked Decreased Splash test to evoke grooming behavior 2-2.75 months Coba MP , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-2.75 months Coba MP , et al. (2018)
Motor phenotype General locomotor activity No change Open field test 2-2.75 months Coba MP , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Coba MP , et al. (2018)
Neurophysiology NA Not reported NA NA Coba MP , et al. (2018)
Repetitive behavior NA Not reported NA NA Coba MP , et al. (2018)
Seizure NA Not reported NA NA Coba MP , et al. (2018)
Sensory Startle response No change Prepulse inhibition 2-2.75 months Coba MP , et al. (2018)
Sensory NA Not reported NA NA Coba MP , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 2-2.75 months Coba MP , et al. (2018)
Social behavior Rearing behavior No change Open field test 2-2.75 months Coba MP , et al. (2018)
Social behavior Nest building behavior No change Nest building assay 2-2.75 months Coba MP , et al. (2018)
Communications NA Not reported NA NA Coba MP , et al. (2018)
Developmental profile NA Not reported NA NA Coba MP , et al. (2018)
Emotion Exploratory activity Decreased Novel cage test 2-2.75 months Coba MP , et al. (2018)
Emotion Depression No change Forced swim test 2-2.75 months Coba MP , et al. (2018)
Emotion Depression No change Sucrose preference test 2-2.75 months Coba MP , et al. (2018)
Emotion Anxiety No change Open field test 2-2.75 months Coba MP , et al. (2018)
Immune response NA Not reported NA NA Coba MP , et al. (2018)
Learning & memory NA Not reported NA NA Coba MP , et al. (2018)
Maternal behavior NA Not reported NA NA Coba MP , et al. (2018)
Molecular profile Targeted expression Decreased Co-immunoprecipitation 2-2.75 months Coba MP , et al. (2018)
Molecular profile Protein expression level evidence No change Western blot 2-2.75 months Coba MP , et al. (2018)
Molecular profile Protein binding Decreased Co-immunoprecipitation 2-2.75 months Coba MP , et al. (2018)
Molecular profile Protein binding No change Co-immunoprecipitation 2-2.75 months Coba MP , et al. (2018)

M_DLGAP1_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Mice harboring a heterozygous null mutation of the DLGAP1 allele. (No other information reported). .

Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129*C57BL/6 J

Es cell line: Not reported
Model Source: Dr. Seth Grant at Edinburgh University.
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Coba MP , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Coba MP , et al. (2018)
Motor phenotype Self grooming: artificial stress evoked No change Splash test to evoke grooming behavior 2-2.75 months Coba MP , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-2.75 months Coba MP , et al. (2018)
Motor phenotype General locomotor activity No change Open field test 2-2.75 months Coba MP , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Coba MP , et al. (2018)
Neurophysiology NA Not reported NA NA Coba MP , et al. (2018)
Repetitive behavior NA Not reported NA NA Coba MP , et al. (2018)
Seizure NA Not reported NA NA Coba MP , et al. (2018)
Sensory Startle response No change Prepulse inhibition 2-2.75 months Coba MP , et al. (2018)
Sensory NA Not reported NA NA Coba MP , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 2-2.75 months Coba MP , et al. (2018)
Social behavior Rearing behavior No change Open field test 2-2.75 months Coba MP , et al. (2018)
Social behavior Nest building behavior No change Nest building assay 2-2.75 months Coba MP , et al. (2018)
Communications NA Not reported NA NA Coba MP , et al. (2018)
Developmental profile NA Not reported NA NA Coba MP , et al. (2018)
Emotion Exploratory activity No change Novel cage test 2-2.75 months Coba MP , et al. (2018)
Emotion Depression No change Forced swim test 2-2.75 months Coba MP , et al. (2018)
Emotion Depression No change Sucrose preference test 2-2.75 months Coba MP , et al. (2018)
Emotion Anxiety No change Open field test 2-2.75 months Coba MP , et al. (2018)
Immune response NA Not reported NA NA Coba MP , et al. (2018)
Learning & memory NA Not reported NA NA Coba MP , et al. (2018)
Maternal behavior NA Not reported NA NA Coba MP , et al. (2018)
Molecular profile NA Not reported NA NA Coba MP , et al. (2018)

M_DLGAP1_3_KO_HM

Model Type: Genetic LOF
Model Genotype: Homozygous

Mutation:

Mutant mice have dlgap1 exon 4 replaced with a selection cassette that creates a frameshift between exons 4 and 5. 795bp of dlgap1 genomic dna (x70662625 to x70663420; ensemble build 68) is replaced with ires-lacz-neo cassette.

Allele Type: Knockout
Strain of Origin: C57BL/6*129S5
Genetic Background: C57BL/6*129S5

Es cell line: E14TG2a
Model Source: University of Edinburgh
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Category Reaction time: cognitive flexibility Decreased Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
Motor phenotype Hyperactivity No change Home cage behavior 10–18weeks Horner AE et al. (2021)
Learning & memory Visual discrimination learning No change Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
Learning & memory Reward reinforced choice behavior No change Operant conditioning paradigm 10–18weeks Horner AE et al. (2021)
Learning & memory Reaction time: visual discrimination Decreased Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
Learning & memory Cognitive flexibility No change Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)

M_DLGAP1_4_KO_HT

Model Type: Genetic LOF
Model Genotype: Heterozygous

Mutation:

Mutant mice have dlgap1 exon 4 replaced with a selection cassette that creates a frameshift between exons 4 and 5. 795bp of dlgap1 genomic dna (x70662625 to x70663420; ensemble build 68) is replaced with ires-lacz-neo cassette.

Allele Type: Knockout
Strain of Origin: C57BL/6*129S5
Genetic Background: C57BL/6*129S5

Es cell line: E14TG2a
Model Source: University of Edinburgh
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Category Reaction time: cognitive flexibility No change Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
Motor phenotype Hyperactivity No change Home cage behavior 10–18weeks Horner AE et al. (2021)
Learning & memory Visual discrimination learning No change Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
Learning & memory Reward reinforced choice behavior No change Operant conditioning paradigm 10–18weeks Horner AE et al. (2021)
Learning & memory Reaction time: visual discrimination No change Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
Learning & memory Cognitive flexibility No change Pairwise visual discrimination task 10–18weeks Horner AE et al. (2021)
CNVs associated with DLGAP1(1 Models)
18p11.31 12 Deletion-Duplication 20  /  49
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