Genetic Animal Models / DYRK1A

DYRK1A dual specificity tyrosine-Y- phosphorylation regulated kinase 1A

Model Species
Mus musculus
Gene Aliases
mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik; ENSMUSG00000074897
Reports
3
Associated Human Genes
DYRK1A
Models / Rescue Models
-
Rescue Model
-
Model Summary

Dyrk1A mutants exhibit alterations in neuromotor development and learning and memory.

Reports related to DYRK1A (3 Reports)
# Type Title Author, Year
1 Primary Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's... Altafaj X , et al. (2001)
2 Primary Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Fotaki V , et al. (2002)
3 Additional Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome. Arranz J , et al. (2019)
Show all Construct Details Show all Phenotypic Profiles

M_Dyrk1a_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

A targeting vector was constructed with homology (5') to 3.6 kb of exon 6 and 2.1 kb of exon 8 (3'), containing PGKneobpA cassette and PGKtk cassette. This construct was linearized and electroporated into E14-1 cells.Dyrk1A+/- mice were mated together to produce the homozygotes.

Allele Type: Targeted knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57Bl/6-129O1a

Es cell line: E14.1 (ES Cell)
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Fotaki V , et al. (2002)
Motor phenotype - Not Reported - - Fotaki V , et al. (2002)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Fotaki V , et al. (2002)
Neurophysiology - Not Reported - - Fotaki V , et al. (2002)
Repetitive behavior - Not Reported - - Fotaki V , et al. (2002)
Seizure - Not Reported - - Fotaki V , et al. (2002)
Sensory - Not Reported - - Fotaki V , et al. (2002)
Social behavior - Not Reported - - Fotaki V , et al. (2002)
Communications - Not Reported - - Fotaki V , et al. (2002)
Developmental profile Size/growth Decreased General observations E9.5, E10.5, E11.5 Fotaki V , et al. (2002)
Developmental profile Mortality/lethality Increased - E9.5-E10 Fotaki V , et al. (2002)
Emotion - Not Reported - - Fotaki V , et al. (2002)
Homeostasis - Not Reported - - Fotaki V , et al. (2002)
Immune response - Not Reported - - Fotaki V , et al. (2002)
Learning & memory - Not Reported - - Fotaki V , et al. (2002)
Maternal behavior - Not Reported - - Fotaki V , et al. (2002)
Molecular profile - Not Reported - - Fotaki V , et al. (2002)

M_Dyrk1a_1_Tg_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Transgenic mice were generated using Dyrk1A full length cDNA into male pronuclei. The cDNA is under the sheep promoter for metallothione IA.

Allele Type: Transgenic
Strain of Origin: C57BL6/SJL
Genetic Background: C57BL6/SJL

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle Circadian rhythm No Change Home cage behavior 4 months Altafaj X , et al. (2001)
Motor phenotype Motor coordination and balance Decreased Wire hang test P14 Altafaj X , et al. (2001)
Motor phenotype Motor coordination and balance Decreased Wire hang test 4 months Altafaj X , et al. (2001)
Motor phenotype Hyperactivity Increased Open field test 4 months Altafaj X , et al. (2001)
Motor phenotype Hyperactivity Increased Elevated plus maze test 4 months Altafaj X , et al. (2001)
Motor phenotype Gait Decreased Pivoting test P7, P10, P14 Altafaj X , et al. (2001)
Motor phenotype Gait Decreased Homing test P7, P10, P14 Altafaj X , et al. (2001)
Motor phenotype Gait Decreased Gait P7, P10, P14 Altafaj X , et al. (2001)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Altafaj X , et al. (2001)
Neurophysiology - Not Reported - - Altafaj X , et al. (2001)
Repetitive behavior - Not Reported - - Altafaj X , et al. (2001)
Seizure - Not Reported - - Altafaj X , et al. (2001)
Sensory - Not Reported - - Altafaj X , et al. (2001)
Social behavior - Not Reported - - Altafaj X , et al. (2001)
Communications - Not Reported - - Altafaj X , et al. (2001)
Developmental profile Reproductive system development No Change General observations P7, P10, P14 Altafaj X , et al. (2001)
Developmental profile Developmental trajectory No Change - P7, P10, P14 Altafaj X , et al. (2001)
Emotion Anxiety Decreased Elevated plus maze test 4 months Altafaj X , et al. (2001)
Homeostasis - Not Reported - - Altafaj X , et al. (2001)
Immune response - Not Reported - - Altafaj X , et al. (2001)
Learning & memory Spatial reference memory No Change - Unreported Altafaj X , et al. (2001)
Learning & memory Spatial reference memory Decreased - Unreported Altafaj X , et al. (2001)
Learning & memory Spatial reference memory No Change Morris water maze test 4 months Altafaj X , et al. (2001)
Learning & memory Cognitive flexibility Decreased Morris water maze test: reversal learning Unreported Altafaj X , et al. (2001)
Maternal behavior - Not Reported - - Altafaj X , et al. (2001)
Molecular profile - Not Reported - - Altafaj X , et al. (2001)

M_Dyrk1a_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

A targeting vector was constructed with homology (5') to 3.6 kb of exon 6 and 2.1 kb of exon 8 (3'), containing PGKneobpA cassette and PGKtk cassette. This construct was linearized and electroporated into E14-1 cells.

Allele Type: Targeted knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57Bl/6-129O1a

Es cell line: E14.1 (ES Cell)
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Fotaki V , et al. (2002)
Motor phenotype Self grooming: artificial stress evoked Increased Resident-intruder test 4-6 months Arranz J , et al. (2019)
Motor phenotype General locomotor activity No Change Marble-burying test 4-6 months Arranz J , et al. (2019)
Motor phenotype Righting response Decreased General observations Unreported Fotaki V , et al. (2002)
Motor phenotype Grip strength No Change - Unreported Fotaki V , et al. (2002)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: Inhibitory No Change Immunohistochemistry Adult Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: Excitatory Increased Immunocytochemistry Adult Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Inhibitory neurons Increased Immunohistochemistry Adult Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: Excitatory neurons Increased Immunohistochemistry Adult Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number in the brain Increased Immunohistochemistry P7 Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal migration No Change Immunohistochemistry P7 Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation and specification in the brain Abnormal Immunohistochemistry P7 Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunohistochemistry P7 Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cell proliferation: neural precursors Increased Immunohistochemistry P7 Arranz J , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased - Adult Fotaki V , et al. (2002)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Histology: nissl staining Adult Fotaki V , et al. (2002)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture No Change Immunohistochemistry P14 Fotaki V , et al. (2002)
Neurophysiology - Not Reported - - Fotaki V , et al. (2002)
Repetitive behavior Self grooming: perseveration Increased Marble-burying test 4-6 months Arranz J , et al. (2019)
Repetitive behavior Repetitive digging Increased Resident-intruder test 4-6 months Arranz J , et al. (2019)
Repetitive behavior Repetitive digging Decreased Marble-burying test 4-6 months Arranz J , et al. (2019)
Repetitive behavior - Not Reported - - Fotaki V , et al. (2002)
Seizure Seizures Increased Electroencephalogram (EEG) 5-6 months Arranz J , et al. (2019)
Seizure Electroencephalogram (EEG): signature of seizure/epilepsy Increased Electroencephalogram (EEG) 5-6 months Arranz J , et al. (2019)
Seizure - Not Reported - - Fotaki V , et al. (2002)
Sensory Vision No Change Forepaw reaching test Unreported Fotaki V , et al. (2002)
Sensory Touch No Change - Unreported Fotaki V , et al. (2002)
Sensory Startle response: acoustic stimulus Decreased - Unreported Fotaki V , et al. (2002)
Social behavior Social interaction Decreased Resident-intruder test 4-6 months Arranz J , et al. (2019)
Social behavior - Not Reported - - Fotaki V , et al. (2002)
Communications Ultrasonic vocalization: Isolation induced Decreased Monitoring ultrasonic vocalizations P3, P6, P9, P12 Arranz J , et al. (2019)
Communications - Not Reported - - Fotaki V , et al. (2002)
Developmental profile Size/growth Decreased General observations E9.5, E10.5, E11.5, adult Fotaki V , et al. (2002)
Developmental profile Mortality/lethality Increased Genotypic ratio of progeny from heterozygous parents: newborn/weaning 0-3 weeks Fotaki V , et al. (2002)
Emotion Anxiety Increased Marble-burying test 4-6 months Arranz J , et al. (2019)
Emotion - Not Reported - - Fotaki V , et al. (2002)
Homeostasis - Not Reported - - Fotaki V , et al. (2002)
Immune response - Not Reported - - Fotaki V , et al. (2002)
Learning & memory - Not Reported - - Fotaki V , et al. (2002)
Maternal behavior - Not Reported - - Fotaki V , et al. (2002)
Molecular profile Targeted protein expression Decreased Quantitative PCR (qRT-PCR) E11.5, E14.5, E16.5, P0, P7, 4 weeks Arranz J , et al. (2019)
Molecular profile Targeted protein expression Decreased Western blot P0, P7 Arranz J , et al. (2019)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) P0, P7 Arranz J , et al. (2019)
Molecular profile Gene expression Abnormal Gene expression microarray P0, P7 Arranz J , et al. (2019)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) P0, P7 Arranz J , et al. (2019)
Molecular profile - Not Reported - - Fotaki V , et al. (2002)
CNVs associated with DYRK1A(1 Models)
21q22.13 5 Deletion-Duplication 9  /  7
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