Genetic Mouse Models / FMR1

FMR1 fragile X mental retardation 1

Model Species
Mus musculus
Gene Aliases
FMRP; Fmr-1
Reports
39
Associated Human Genes
FMR1
Models / Rescue Models
62 / 23
Rescue Model
-
Model Summary

Fragile X Syndrome.

Reports related to FMR1 (39 Reports)
# Type Title Author, Year
1 Additional Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Koekkoek SK , et al. (2005)
2 Additional Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model. Gantois I , et al. (2005)
3 Additional The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Mientjes EJ , et al. (2005)
4 Additional Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein. Selby L , et al. (2007)
5 Additional Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. Schtt J , et al. (2009)
6 Additional Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. Shang Y , et al. (2009)
7 Additional Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Eadie BD , et al. (2009)
8 Additional Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. Yuskaitis CJ , et al. (2009)
9 Additional Altered neuroligin expression is involved in social deficits in a mouse model of the fragile X syndrome. Dahlhaus R and El-Husseini A (2009)
10 Additional A mouse model of the human Fragile X syndrome I304N mutation. Zang JB , et al. (2009)
11 Additional Dysregulation of mTOR signaling in fragile X syndrome. Sharma A , et al. (2010)
12 Additional GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism. Mines MA , et al. (2010)
13 Additional A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis. Qin M , et al. (2011)
14 Additional Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. Testa-Silva G , et al. (2011)
15 Additional Reversal of fragile X phenotypes by manipulation of APP/A levels in Fmr1KO mice. Westmark CJ , et al. (2011)
16 Additional The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. Olmos-Serrano JL , et al. (2011)
17 Additional Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome. Rotschafer SE , et al. (2012)
18 Additional Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Michalon A , et al. (2012)
19 Additional Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, ... Costa L , et al. (2012)
20 Additional Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. Bhattacharya A , et al. (2012)
21 Additional Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder. Rogers TD , et al. (2013)
22 Additional Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Dolan BM , et al. (2013)
23 Additional Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. Dansie LE , et al. (2013)
24 Additional Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model. Lim CS , et al. (2014)
25 Additional Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Tyzio R , et al. (2014)
26 Additional Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse. Srensen EM , et al. (2015)
27 Additional Convergence of Hippocampal Pathophysiology in Syngap and Fmr1-/y Mice. Barnes SA , et al. (2015)
28 Additional Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Orefice LL , et al. (2016)
29 Additional Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Korb E , et al. (2017)
30 Additional Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor- expression. Hodges SL , et al. (2017)
31 Additional Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Yau SY , et al. (2018)
32 Additional Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors. Lee Y , et al. (2019)
33 Additional Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models. Antoine MW , et al. (2019)
34 Additional Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Orefice LL , et al. (2019)
35 Additional IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders </title> ()
36 Additional Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations Xu ZX et al. (2020)
37 Additional ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome Licznerski P et al. (2020)
38 Primary Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. no authors (1994)
39 Primary Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Comery TA , et al. (1997)
Show all Construct Details Show all Phenotypic Profiles

M_FMR1_10_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Purkinje cell specific knock out of FMR1, using L7-cre mice.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: mixed

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Koekkoek SK , et al. (2005)
Circadian sleep/wake cycle NA Not reported NA NA Koekkoek SK , et al. (2005)
Motor phenotype Spontaneous movement Increased Home cage behavior Unreported Koekkoek SK , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Measurement of tissue weight 2 months Koekkoek SK , et al. (2005)
Neurophysiology NA Not reported NA NA Koekkoek SK , et al. (2005)
Repetitive behavior NA Not reported NA NA Koekkoek SK , et al. (2005)
Seizure NA Not reported NA NA Koekkoek SK , et al. (2005)
Sensory NA Not reported NA NA Koekkoek SK , et al. (2005)
Social behavior Social interaction No change Reciprocal social interaction test Unreported Koekkoek SK , et al. (2005)
Social behavior Social interaction Increased Light-dark exploration test Unreported Koekkoek SK , et al. (2005)
Communications NA Not reported NA NA Koekkoek SK , et al. (2005)
Developmental profile Size/growth Increased Measurement of tissue weight 5-7 weeks, 2.5 months; 3.5 months; 5.5 months Koekkoek SK , et al. (2005)
Developmental profile Reproductive system development No change General observations Unreported Koekkoek SK , et al. (2005)
Emotion NA Not reported NA NA Koekkoek SK , et al. (2005)
Immune response NA Not reported NA NA Koekkoek SK , et al. (2005)
Learning & memory Spatial learning No change Morris water maze test Unreported Koekkoek SK , et al. (2005)
Learning & memory Spatial learning Decreased Morris water maze test Unreported Koekkoek SK , et al. (2005)
Learning & memory Cued or contextual fear conditioning No change Fear conditioning test Unreported Koekkoek SK , et al. (2005)
Maternal behavior NA Not reported NA NA Koekkoek SK , et al. (2005)
Molecular profile NA Not reported NA NA Koekkoek SK , et al. (2005)

M_FMR1_11_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

FMR1 KO mice with a mixed FVB and 129P2 background(information not available for pde6b+.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: FVB.129P2

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Sharma A , et al. (2010)
Circadian sleep/wake cycle NA Not reported NA NA Sharma A , et al. (2010)
Motor phenotype General locomotor activity Increased Observation of repetitive behavior 2 months Licznerski P et al. (2020)
Motor phenotype NA Not reported NA NA Sharma A , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology: active zone Decreased Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Decreased Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Mitochondrial number Decreased Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Mitochondrial matrix morphology Increased Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Mitochondrial crista morphology No change Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Decreased Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Abnormal Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Sharma A , et al. (2010)
Neurophysiology Mitochondrial membrane potential Increased Whole-cell patch clamp 2 months Licznerski P et al. (2020)
Neurophysiology Mitochondrial ATP synthesis coupled electron transport Decreased 9-amino-6-chloro-2-methoxyacridine (ACMA) assay 2 months Licznerski P et al. (2020)
Neurophysiology NA Not reported NA NA Sharma A , et al. (2010)
Repetitive behavior Stereotypy: chewing behavior Increased Observation of repetitive behavior 2 months Licznerski P et al. (2020)
Repetitive behavior Self grooming Increased Grooming behavior assessments 2 months Licznerski P et al. (2020)
Repetitive behavior NA Not reported NA NA Sharma A , et al. (2010)
Seizure NA Not reported NA NA Sharma A , et al. (2010)
Sensory NA Not reported NA NA Sharma A , et al. (2010)
Social behavior NA Not reported NA NA Sharma A , et al. (2010)
Communications NA Not reported NA NA Sharma A , et al. (2010)
Developmental profile NA Not reported NA NA Sharma A , et al. (2010)
Emotion NA Not reported NA NA Sharma A , et al. (2010)
Immune response NA Not reported NA NA Sharma A , et al. (2010)
Learning & memory NA Not reported NA NA Sharma A , et al. (2010)
Maternal behavior NA Not reported NA NA Sharma A , et al. (2010)
Molecular profile Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) Increased - - -
Molecular profile Tricarboxylic acid cycle Increased Liquid chromatography-mass spectrometry (LC-MS) 2 months Licznerski P et al. (2020)
Molecular profile Regulation of translation Increased Puromycin incorporation assay 2 months Licznerski P et al. (2020)
Molecular profile Regulation of translation Increased Electron microscopy 2 months Licznerski P et al. (2020)
Molecular profile Protein binding Decreased Co-immunoprecipitation 2 months Licznerski P et al. (2020)
Molecular profile Neuronal activity dependent translation Decreased Western blot 2 months Licznerski P et al. (2020)
Molecular profile Neuronal activity dependent phosphorylation Decreased Western blot 2 months Licznerski P et al. (2020)
Molecular profile Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Increased Native non-denaturing polyacrylamide gel electrophoresis 2 months Licznerski P et al. (2020)
Molecular profile Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Increased Western blot 2 months Licznerski P et al. (2020)
Molecular profile Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) Increased Western blot 2 months Licznerski P et al. (2020)
Molecular profile Mitochondrial proton-transporting ATP synthase complex assembly No change Native non-denaturing polyacrylamide gel electrophoresis 2 months Licznerski P et al. (2020)
Molecular profile Glycolysis Increased Liquid chromatography-mass spectrometry (LC-MS) 2 months Licznerski P et al. (2020)
Molecular profile Regulation of gene expression Increased Western blot 4-6 weeks Sharma A , et al. (2010)
Molecular profile Protein phosphorylation No change Western blot 4-6 weeks Sharma A , et al. (2010)
Molecular profile Protein phosphorylation Increased Western blot 4-6 weeks, 6-8 months Sharma A , et al. (2010)
Molecular profile Protein expression level evidence No change Western blot 4-6 weeks; 6-8 months Sharma A , et al. (2010)
Molecular profile Enzyme activity No change Western blot 4-6 weeks Sharma A , et al. (2010)
Molecular profile Enzyme activity Increased Western blot 4-6 weeks Sharma A , et al. (2010)

M_FMR1_11_KO_HM_CYCLOSPORIN-A

Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous

Mutation:

Brain slices from fvb.129p2 mice that have a neomycin resistance cassette replacing exon 5 were treated with cyclosporina or vehicle for 2.5 hours at a final concentraion between 0.2 and 0.5 um, before electron microscopy.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: FVB.129P2

Es cell line: NA
Model Source: Jackson Laboratories
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Molecular profile Regulation of translation Ameliorated Electron microscopy 2 months Licznerski P et al. (2020)
Molecular profile Neuronal activity dependent translation Restored Western blot 2 months Licznerski P et al. (2020)
Molecular profile Neuronal activity dependent phosphorylation Restored Western blot 2 months Licznerski P et al. (2020)

M_FMR1_11_KO_HM_DEXPRAMIPEXOLE-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous

Mutation:

Dexpramipexole was added to the electrophysiology bath at a final concentration 10 mm with ex vivo cortical slices from fvb.129p2 mice that have a neomycin resistance cassette replacing exon 5.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: FVB.129P2

Es cell line: NA
Model Source: Jackson Laboratories
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Restored Electron microscopy 2 months Licznerski P et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Electron microscopy 2 months Licznerski P et al. (2020)
Neurophysiology Mitochondrial membrane potential Ameliorated Whole-cell patch clamp 2 months Licznerski P et al. (2020)
Neurophysiology Mitochondrial ATP synthesis coupled electron transport Restored 9-amino-6-chloro-2-methoxyacridine (ACMA) assay 2 months Licznerski P et al. (2020)
Molecular profile Regulation of translation Restored Puromycin incorporation assay 2 months Licznerski P et al. (2020)

M_FMR1_11_KO_HM_DEXPRAMIPEXOLE-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous

Mutation:

2-month old fmr1^-/y mutant fvb.129p2 mice that have a neomycin resistance cassette replacing exon 5 were injected with dexpramipexole including 3 intraperitoneal injections of 10 mg/kg dex or saline over 40 h prior to behavioral testing.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: FVB.129P2

Es cell line: NA
Model Source: Jackson Laboratories
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype General locomotor activity Restored Observation of repetitive behavior 2 months Licznerski P et al. (2020)
Repetitive behavior Stereotypy: chewing behavior Restored Observation of repetitive behavior 2 months Licznerski P et al. (2020)
Repetitive behavior Self grooming Restored Grooming behavior assessments 2 months Licznerski P et al. (2020)

M_FMR1_12_KO_HM

Model Type: Genetic
Model Genotype: Homozygous; hemizygous

Mutation:

FMR1 knockout mice on the FVB/NJ background. (Construct details not available).

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: FVB/NJ

Es cell line: Not Specified
Model Source: Lugo Lab, Baylor University (PMID 28915148)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Hodges SL , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Hodges SL , et al. (2017)
Motor phenotype NA Not reported NA NA Hodges SL , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Hodges SL , et al. (2017)
Neurophysiology NA Not reported NA NA Hodges SL , et al. (2017)
Repetitive behavior NA Not reported NA NA Hodges SL , et al. (2017)
Seizure NA Not reported NA NA Hodges SL , et al. (2017)
Sensory NA Not reported NA NA Hodges SL , et al. (2017)
Social behavior NA Not reported NA NA Hodges SL , et al. (2017)
Communications NA Not reported NA NA Hodges SL , et al. (2017)
Developmental profile NA Not reported NA NA Hodges SL , et al. (2017)
Emotion NA Not reported NA NA Hodges SL , et al. (2017)
Immune response Cytokine levels: pro-inflammatory No change Quantitative pcr (qrt-pcr) Adult Hodges SL , et al. (2017)
Immune response Cytokine levels: pro-inflammatory Decreased Quantitative pcr (qrt-pcr) Adult Hodges SL , et al. (2017)
Immune response Cytokine levels: chemokine No change Quantitative pcr (qrt-pcr) Adult Hodges SL , et al. (2017)
Immune response Cytokine levels: anti-inflammatory No change Quantitative pcr (qrt-pcr) Adult Hodges SL , et al. (2017)
Learning & memory NA Not reported NA NA Hodges SL , et al. (2017)
Maternal behavior NA Not reported NA NA Hodges SL , et al. (2017)
Molecular profile NA Not reported NA NA Hodges SL , et al. (2017)

M_FMR1_13_KD

Model Type: Genetic
Model Genotype: Wildtype

Mutation:

Seven-week-old wildtype C57BL/6 male mice were injected with Fmr1-siRNA (1358762, NM_008031.2), bilaterally in the dorsal striatum using a stereotaxic apparatus, resulting in a reduction of Fmr1 transcript levels to 0.4 fold compared with control siRNA injected mice.

Allele Type: Knockdown
Strain of Origin: C57BL/6
Genetic Background: C57BL/6

Es cell line: NA
Model Source: Daehan BioLink (Eumsung, Chungbuk, Republic of Korea)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lee Y , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Lee Y , et al. (2019)
Motor phenotype NA Not reported NA NA Lee Y , et al. (2019)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lee Y , et al. (2019)
Neurophysiology NA Not reported NA NA Lee Y , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments Adult Lee Y , et al. (2019)
Repetitive behavior Repetitive digging No change Home cage behavior Adult Lee Y , et al. (2019)
Seizure NA Not reported NA NA Lee Y , et al. (2019)
Sensory NA Not reported NA NA Lee Y , et al. (2019)
Social behavior Social memory Decreased U-field assay Adult Lee Y , et al. (2019)
Communications NA Not reported NA NA Lee Y , et al. (2019)
Developmental profile NA Not reported NA NA Lee Y , et al. (2019)
Emotion NA Not reported NA NA Lee Y , et al. (2019)
Immune response NA Not reported NA NA Lee Y , et al. (2019)
Learning & memory Object recognition memory Decreased Object preference test Adult Lee Y , et al. (2019)
Maternal behavior NA Not reported NA NA Lee Y , et al. (2019)
Molecular profile Targeted expression Decreased Quantitative pcr (qrt-pcr) Adult Lee Y , et al. (2019)

M_FMR1_14_KO_HE

Model Type: Genetic
Model Genotype: Homozygous/Hemizygous

Mutation:

FMR1 mutant gene was generated by construction a targeting vector using homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo). FMR1 homozygous knockout mice (FMR1^tm1Cgr) were bred with NeuroD1 bacTRAP (ND1-BT) heterozygous mice (PMID 28823556) to generate FMR1 and ND-BT1 dual heterozygous female mice that were bred with FMR1-/y male mice to generate FMR1 null and ND1-BT heterozygous (FMR1-/-;ND1-BT /-) that were used for experimentations; M_FMR1_1_KO_HM

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J*129/SvEv*CD1

Es cell line: -
Model Source: Not specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 6-8 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Increased Response to air puff 6-8 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Increased Prepulse inhibition 6-8 weeks Orefice LL , et al. (2019)

M_FMR1_14_KO_HE_ISOGUVACINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous/Hemizygous

Mutation:

Isoguvacine is a potent and selective agonist for the GABAAR that does not cross the blood brain barrier and so is a peripherally restricted GABAAR agonist. Isoguvacine, 2 mg/kg, i.p., was administered beginning at a young age (P1-P42) to test if it ameliorated tactile hypersensitivity in ASD models with fewer adverse effects than brain-penetrating benzodiazepines such as midazolam, including sedation and cognitive impairment, which are attributed to a CNS site of drug action.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J*129/SvEv*CD1

Es cell line: -
Model Source: Not specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Sensory Startle response: acoustic stimulus No adverse effect Acoustic startle reflex test 6 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Restored Response to air puff 6 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Restored Prepulse inhibition 6 weeks Orefice LL , et al. (2019)

M_FMR1_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous; hemizygous

Mutation:

FMR1 mutant gene was generated by construction a targeting vector using homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo). FMR1 homozygous knockout mice (FMR1^tm1Cgr) were bred with NeuroD1 bacTRAP (ND1-BT) heterozygous mice (PMID 28823556) to generate FMR1 and ND-BT1 dual heterozygous female mice that were bred with FMR1-/y male mice to generate FMR1 null and ND1-BT heterozygous (FMR1-/-;ND1-BT+/-) that were used for experimentations.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J

Es cell line: E14
Model Source: The Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Comery TA , et al. (1997)
Physiological parameters NA Not reported NA NA ()
Physiological parameters NA Not reported NA NA Yau SY , et al. (2018)
Physiological parameters NA Not reported NA NA Korb E , et al. (2017)
Physiological parameters NA Not reported NA NA Srensen EM , et al. (2015)
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Physiological parameters NA Not reported NA NA Rogers TD , et al. (2013)
Physiological parameters NA Not reported NA NA Michalon A , et al. (2012)
Physiological parameters NA Not reported NA NA Rotschafer SE , et al. (2012)
Physiological parameters NA Not reported NA NA Westmark CJ , et al. (2011)
Physiological parameters NA Not reported NA NA Testa-Silva G , et al. (2011)
Physiological parameters NA Not reported NA NA Mines MA , et al. (2010)
Physiological parameters NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Physiological parameters NA Not reported NA NA Eadie BD , et al. (2009)
Physiological parameters Hormone levels No change Elisa Unreported Eadie BD , et al. (2009)
Physiological parameters Hormone levels Decreased Elisa Unreported Eadie BD , et al. (2009)
Physiological parameters NA Not reported NA NA Schtt J , et al. (2009)
Physiological parameters NA Not reported NA NA Gantois I , et al. (2005)
Circadian sleep/wake cycle NA Not reported NA NA Comery TA , et al. (1997)
Circadian sleep/wake cycle NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA Yau SY , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Korb E , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Srensen EM , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Rogers TD , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Michalon A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Rotschafer SE , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Westmark CJ , et al. (2011)
Circadian sleep/wake cycle NA Not reported NA NA Testa-Silva G , et al. (2011)
Circadian sleep/wake cycle NA Not reported NA NA Mines MA , et al. (2010)
Circadian sleep/wake cycle NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Circadian sleep/wake cycle NA Not reported NA NA Eadie BD , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Schtt J , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Gantois I , et al. (2005)
Motor phenotype NA Not reported NA NA Comery TA , et al. (1997)
Motor phenotype NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA Yau SY , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 5 weeks Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Increased Open field test 4-8 weeks Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Increased Novel object recognition test 4-8 weeks Korb E , et al. (2017)
Motor phenotype Hyperactivity Increased Three-chamber social approach test 7-10 weeks Srensen EM , et al. (2015)
Motor phenotype Hyperactivity Increased Open field test 7-10 weeks Srensen EM , et al. (2015)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Rogers TD , et al. (2013)
Motor phenotype General locomotor activity Increased Open field test 2-5 months Michalon A , et al. (2012)
Motor phenotype NA Not reported NA NA Rotschafer SE , et al. (2012)
Motor phenotype General locomotor activity No change Open field test Unreported Westmark CJ , et al. (2011)
Motor phenotype NA Not reported NA NA Testa-Silva G , et al. (2011)
Motor phenotype NA Not reported NA NA Mines MA , et al. (2010)
Motor phenotype Swimming ability Increased Swim test 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Motor phenotype General locomotor activity Increased Open field test 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Motor phenotype General locomotor activity No change Open field test Unreported Eadie BD , et al. (2009)
Motor phenotype NA Not reported NA NA Schtt J , et al. (2009)
Motor phenotype NA Not reported NA NA Gantois I , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Immunohistochemistry 8 weeks Comery TA , et al. (1997)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial number No change Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial number Increased Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial morphology No change Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial morphology Increased Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: nmda receptors Decreased Western blot Adult Yau SY , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis Adult Yau SY , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Sholl analysis Adult Yau SY , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Immunohistochemistry 4-8 weeks Korb E , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Srensen EM , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Rogers TD , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Golgi-cox staining Unreported Michalon A , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Rotschafer SE , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Westmark CJ , et al. (2011)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Testa-Silva G , et al. (2011)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Mines MA , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Decreased Immunohistochemistry 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain development No change Immunohistochemistry Unreported Eadie BD , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain development Decreased Immunohistochemistry Unreported Eadie BD , et al. (2009)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Schtt J , et al. (2009)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Gantois I , et al. (2005)
Neurophysiology NA Not reported NA NA Comery TA , et al. (1997)
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult, 2-5 months, 9-12 months ()
Neurophysiology Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission Decreased Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: excitatory Decreased Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Epsp-spike relationship No change Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Epsp-spike relationship Decreased Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology NA Not reported NA NA Korb E , et al. (2017)
Neurophysiology Neurotransmitter release: catecholamines Increased High-performance liquid chromatography (hplc) 7-10 weeks Srensen EM , et al. (2015)
Neurophysiology NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology Neurotransmitter release: catecholamines No change In vivo amperometry Unreported Rogers TD , et al. (2013)
Neurophysiology Neurotransmitter release: catecholamines Decreased In vivo amperometry Unreported Rogers TD , et al. (2013)
Neurophysiology Neurotransmitter release: catecholamines Decreased In vivo amperometry Unreported Rogers TD , et al. (2013)
Neurophysiology Synaptic plasticity: ltd Increased Field potential recordings 3-4 weeks Michalon A , et al. (2012)
Neurophysiology Synaptic plasticity Increased Field potential recordings 2 months Michalon A , et al. (2012)
Neurophysiology NA Not reported NA NA Rotschafer SE , et al. (2012)
Neurophysiology Synaptic plasticity Increased Field potential recordings 3 months Westmark CJ , et al. (2011)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Paired-pulse ratio Unreported Westmark CJ , et al. (2011)
Neurophysiology Synaptic transmission No change Whole-cell patch clamp 4-5 weeks Testa-Silva G , et al. (2011)
Neurophysiology Synaptic transmission Increased Whole-cell patch clamp Unreported Testa-Silva G , et al. (2011)
Neurophysiology Synaptic plasticity: ltd No change Whole-cell patch clamp 4-5 weeks Testa-Silva G , et al. (2011)
Neurophysiology Synaptic plasticity: ltd Decreased Whole-cell patch clamp Unreported Testa-Silva G , et al. (2011)
Neurophysiology NA Not reported NA NA Mines MA , et al. (2010)
Neurophysiology NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Neurophysiology NA Not reported NA NA Eadie BD , et al. (2009)
Neurophysiology NA Not reported NA NA Schtt J , et al. (2009)
Neurophysiology NA Not reported NA NA Gantois I , et al. (2005)
Repetitive behavior NA Not reported NA NA Comery TA , et al. (1997)
Repetitive behavior NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA Yau SY , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 4.3 weeks, 6-8 weeks Korb E , et al. (2017)
Repetitive behavior Repetitive digging No change Marble-burying test 4-6 weeks Srensen EM , et al. (2015)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Rogers TD , et al. (2013)
Repetitive behavior NA Not reported NA NA Michalon A , et al. (2012)
Repetitive behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Repetitive behavior Repetitive digging Decreased Marble-burying test 8-10 weeks Westmark CJ , et al. (2011)
Repetitive behavior NA Not reported NA NA Testa-Silva G , et al. (2011)
Repetitive behavior NA Not reported NA NA Mines MA , et al. (2010)
Repetitive behavior NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Repetitive behavior NA Not reported NA NA Eadie BD , et al. (2009)
Repetitive behavior NA Not reported NA NA Schtt J , et al. (2009)
Repetitive behavior NA Not reported NA NA Gantois I , et al. (2005)
Seizure NA Not reported NA NA Comery TA , et al. (1997)
Seizure NA Not reported NA NA ()
Seizure NA Not reported NA NA Yau SY , et al. (2018)
Seizure NA Not reported NA NA Korb E , et al. (2017)
Seizure NA Not reported NA NA Srensen EM , et al. (2015)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Rogers TD , et al. (2013)
Seizure Seizures Increased Acoustic startle reflex test Unreported Michalon A , et al. (2012)
Seizure NA Not reported NA NA Rotschafer SE , et al. (2012)
Seizure Seizures Increased Audiogenic seizure test P21 Westmark CJ , et al. (2011)
Seizure NA Not reported NA NA Testa-Silva G , et al. (2011)
Seizure NA Not reported NA NA Mines MA , et al. (2010)
Seizure NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Seizure NA Not reported NA NA Eadie BD , et al. (2009)
Seizure NA Not reported NA NA Schtt J , et al. (2009)
Seizure NA Not reported NA NA Gantois I , et al. (2005)
Sensory NA Not reported NA NA Comery TA , et al. (1997)
Sensory NA Not reported NA NA ()
Sensory NA Not reported NA NA Yau SY , et al. (2018)
Sensory NA Not reported NA NA Korb E , et al. (2017)
Sensory NA Not reported NA NA Srensen EM , et al. (2015)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Rogers TD , et al. (2013)
Sensory Startle response: acoustic stimulus Increased Acoustic startle reflex test Unreported Michalon A , et al. (2012)
Sensory NA Not reported NA NA Rotschafer SE , et al. (2012)
Sensory NA Not reported NA NA Westmark CJ , et al. (2011)
Sensory NA Not reported NA NA Testa-Silva G , et al. (2011)
Sensory NA Not reported NA NA Mines MA , et al. (2010)
Sensory NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Sensory NA Not reported NA NA Eadie BD , et al. (2009)
Sensory NA Not reported NA NA Schtt J , et al. (2009)
Sensory NA Not reported NA NA Gantois I , et al. (2005)
Social behavior Social memory Decreased Three-chamber social approach test 7-10 weeks Srensen EM , et al. (2015)
Social behavior Social memory Decreased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction No change Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction No change Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction No change Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction Increased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction Increased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction Decreased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction Decreased Reciprocal social interaction test 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Social behavior Social interaction Decreased Reciprocal social interaction test 2-6 months Dahlhaus R and El-Husseini A (2009)
Social behavior NA Not reported NA NA Comery TA , et al. (1997)
Social behavior Social approach Decreased Three-chamber social approach test Adult ()
Social behavior NA Not reported NA NA Yau SY , et al. (2018)
Social behavior Social approach Increased Three-chamber social approach test 4.3 weeks, 6-8 weeks Korb E , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test 7-10 weeks Srensen EM , et al. (2015)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Rogers TD , et al. (2013)
Social behavior NA Not reported NA NA Michalon A , et al. (2012)
Social behavior Mating behavior No change Reciprocal social interaction test Unreported Rotschafer SE , et al. (2012)
Social behavior NA Not reported NA NA Westmark CJ , et al. (2011)
Social behavior NA Not reported NA NA Testa-Silva G , et al. (2011)
Social behavior Social approach No change Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social approach No change Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social approach Increased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Self grooming: social context No change Three-chamber social approach test 3 months Mines MA , et al. (2010)
Social behavior Social interaction Decreased Resident-intruder test 2-6 months Dahlhaus R and El-Husseini A (2009)
Social behavior Aggression No change Resident-intruder test 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Social behavior NA Not reported NA NA Eadie BD , et al. (2009)
Social behavior NA Not reported NA NA Schtt J , et al. (2009)
Social behavior NA Not reported NA NA Gantois I , et al. (2005)
Communications NA Not reported NA NA Comery TA , et al. (1997)
Communications NA Not reported NA NA ()
Communications NA Not reported NA NA Yau SY , et al. (2018)
Communications NA Not reported NA NA Korb E , et al. (2017)
Communications NA Not reported NA NA Srensen EM , et al. (2015)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations Unreported Lim CS , et al. (2014)
Communications NA Not reported NA NA Rogers TD , et al. (2013)
Communications NA Not reported NA NA Michalon A , et al. (2012)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations Unreported Rotschafer SE , et al. (2012)
Communications NA Not reported NA NA Westmark CJ , et al. (2011)
Communications NA Not reported NA NA Testa-Silva G , et al. (2011)
Communications NA Not reported NA NA Mines MA , et al. (2010)
Communications NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Communications NA Not reported NA NA Eadie BD , et al. (2009)
Communications NA Not reported NA NA Schtt J , et al. (2009)
Communications NA Not reported NA NA Gantois I , et al. (2005)
Developmental profile NA Not reported NA NA Comery TA , et al. (1997)
Developmental profile NA Not reported NA NA ()
Developmental profile NA Not reported NA NA Yau SY , et al. (2018)
Developmental profile NA Not reported NA NA Korb E , et al. (2017)
Developmental profile NA Not reported NA NA Srensen EM , et al. (2015)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Rogers TD , et al. (2013)
Developmental profile Tissue weight Increased General observations 5-17 weeks Michalon A , et al. (2012)
Developmental profile NA Not reported NA NA Rotschafer SE , et al. (2012)
Developmental profile NA Not reported NA NA Westmark CJ , et al. (2011)
Developmental profile NA Not reported NA NA Testa-Silva G , et al. (2011)
Developmental profile NA Not reported NA NA Mines MA , et al. (2010)
Developmental profile Size/growth Increased General observations 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Developmental profile Mortality/lethality No change General observations 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Developmental profile NA Not reported NA NA Eadie BD , et al. (2009)
Developmental profile NA Not reported NA NA Schtt J , et al. (2009)
Developmental profile NA Not reported NA NA Gantois I , et al. (2005)
Emotion NA Not reported NA NA Comery TA , et al. (1997)
Emotion NA Not reported NA NA ()
Emotion Exploratory activity: habituation No change Object-place recognition test Adult Yau SY , et al. (2018)
Emotion Depression No change Forced swim test Adult Yau SY , et al. (2018)
Emotion Depression No change Tail suspension test Adult Yau SY , et al. (2018)
Emotion Anxiety No change Open field test Adult Yau SY , et al. (2018)
Emotion Anxiety No change Open field test 6-8 weeks Korb E , et al. (2017)
Emotion Anxiety Increased Open field test 5 weeks Korb E , et al. (2017)
Emotion Anxiety Increased Open field test 7-10 weeks Srensen EM , et al. (2015)
Emotion Anxiety Decreased Elevated plus maze test P29 Lim CS , et al. (2014)
Emotion Anxiety Decreased Light-dark exploration test P29 Lim CS , et al. (2014)
Emotion NA Not reported NA NA Rogers TD , et al. (2013)
Emotion NA Not reported NA NA Michalon A , et al. (2012)
Emotion NA Not reported NA NA Rotschafer SE , et al. (2012)
Emotion Anxiety Decreased Open field test Unreported Westmark CJ , et al. (2011)
Emotion NA Not reported NA NA Testa-Silva G , et al. (2011)
Emotion Anxiety Increased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Emotion Anxiety Decreased Three-chamber social approach test 3 months Mines MA , et al. (2010)
Emotion NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Emotion Anxiety Decreased Elevated plus maze test 2-4 months Eadie BD , et al. (2009)
Emotion Anxiety Decreased Open field test 2-4 months Eadie BD , et al. (2009)
Emotion NA Not reported NA NA Schtt J , et al. (2009)
Emotion NA Not reported NA NA Gantois I , et al. (2005)
Immune response NA Not reported NA NA Comery TA , et al. (1997)
Immune response NA Not reported NA NA ()
Immune response NA Not reported NA NA Yau SY , et al. (2018)
Immune response NA Not reported NA NA Korb E , et al. (2017)
Immune response NA Not reported NA NA Srensen EM , et al. (2015)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Immune response NA Not reported NA NA Rogers TD , et al. (2013)
Immune response NA Not reported NA NA Michalon A , et al. (2012)
Immune response NA Not reported NA NA Rotschafer SE , et al. (2012)
Immune response NA Not reported NA NA Westmark CJ , et al. (2011)
Immune response NA Not reported NA NA Testa-Silva G , et al. (2011)
Immune response NA Not reported NA NA Mines MA , et al. (2010)
Immune response NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Immune response NA Not reported NA NA Eadie BD , et al. (2009)
Immune response NA Not reported NA NA Schtt J , et al. (2009)
Immune response NA Not reported NA NA Gantois I , et al. (2005)
Learning & memory NA Not reported NA NA Comery TA , et al. (1997)
Learning & memory NA Not reported NA NA ()
Learning & memory Spatial reference memory Decreased Object-place recognition test Adult Yau SY , et al. (2018)
Learning & memory Procedural learning No change Novel object recognition test Adult Yau SY , et al. (2018)
Learning & memory Object recognition memory Decreased Novel object recognition test Adult Yau SY , et al. (2018)
Learning & memory Object recognition memory Decreased Novel object recognition test 4-8 weeks Korb E , et al. (2017)
Learning & memory NA Not reported NA NA Srensen EM , et al. (2015)
Learning & memory Reward reinforced choice behavior Decreased Y-maze test P29 Lim CS , et al. (2014)
Learning & memory Eye blink conditioning Decreased Eyeblink conditioning Unreported Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test P29 Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test P29 Lim CS , et al. (2014)
Learning & memory NA Not reported NA NA Rogers TD , et al. (2013)
Learning & memory Cued or contextual fear conditioning: memory of cue Decreased Passive avoidance test Unreported Michalon A , et al. (2012)
Learning & memory NA Not reported NA NA Rotschafer SE , et al. (2012)
Learning & memory NA Not reported NA NA Westmark CJ , et al. (2011)
Learning & memory NA Not reported NA NA Testa-Silva G , et al. (2011)
Learning & memory NA Not reported NA NA Mines MA , et al. (2010)
Learning & memory Spatial learning No change Morris water maze test 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Learning & memory Object recognition memory No change Novel object recognition test 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Learning & memory Spatial reference memory No change Morris water maze test 2-4 months Eadie BD , et al. (2009)
Learning & memory Spatial reference memory No change Plus-shaped water maze test 2-4 months Eadie BD , et al. (2009)
Learning & memory NA Not reported NA NA Schtt J , et al. (2009)
Learning & memory NA Not reported NA NA Gantois I , et al. (2005)
Maternal behavior NA Not reported NA NA Comery TA , et al. (1997)
Maternal behavior NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA Yau SY , et al. (2018)
Maternal behavior NA Not reported NA NA Korb E , et al. (2017)
Maternal behavior NA Not reported NA NA Srensen EM , et al. (2015)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Rogers TD , et al. (2013)
Maternal behavior NA Not reported NA NA Michalon A , et al. (2012)
Maternal behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Maternal behavior NA Not reported NA NA Westmark CJ , et al. (2011)
Maternal behavior NA Not reported NA NA Testa-Silva G , et al. (2011)
Maternal behavior NA Not reported NA NA Mines MA , et al. (2010)
Maternal behavior NA Not reported NA NA Dahlhaus R and El-Husseini A (2009)
Maternal behavior NA Not reported NA NA Eadie BD , et al. (2009)
Maternal behavior NA Not reported NA NA Schtt J , et al. (2009)
Maternal behavior NA Not reported NA NA Gantois I , et al. (2005)
Molecular profile NA Not reported NA NA Comery TA , et al. (1997)
Molecular profile NA Not reported NA NA ()
Molecular profile Protein phosphorylation Increased Western blot Adult Yau SY , et al. (2018)
Molecular profile Protein localization: synapse Decreased Western blot Adult Yau SY , et al. (2018)
Molecular profile Regulation of gene expression Abnormal Rna sequencing 2.1 weeks Korb E , et al. (2017)
Molecular profile Protein-dna complex assembly Increased Quantitative pcr (qrt-pcr) 2.1 weeks Korb E , et al. (2017)
Molecular profile Protein phosphorylation Increased Western blot 2.1 weeks Korb E , et al. (2017)
Molecular profile Protein expression level evidence Increased Western blot 2.1 weeks Korb E , et al. (2017)
Molecular profile Gene expression Increased Quantitative pcr (qrt-pcr) Not specified Korb E , et al. (2017)
Molecular profile Chromatin modification: histone modification: open chromatin Increased Chromatin immunoprecipitation sequencing (chip-seq) 2.1 weeks Korb E , et al. (2017)
Molecular profile Chromatin modification No change Chromatin immunoprecipitation sequencing (chip-seq) 2.1 weeks Korb E , et al. (2017)
Molecular profile NA Not reported NA NA Srensen EM , et al. (2015)
Molecular profile Signaling Decreased Western blot P14, p29 Lim CS , et al. (2014)
Molecular profile Protein modification process Increased Western blot P14, p29 Lim CS , et al. (2014)
Molecular profile NA Not reported NA NA Rogers TD , et al. (2013)
Molecular profile Signaling Decreased Western blot Unreported Michalon A , et al. (2012)
Molecular profile Regulation of translation Increased Metabolic labeling of proteins Unreported Michalon A , et al. (2012)
Molecular profile NA Not reported NA NA Rotschafer SE , et al. (2012)
Molecular profile Protein expression level evidence Increased Western blot 1 month Westmark CJ , et al. (2011)
Molecular profile NA Not reported NA NA Testa-Silva G , et al. (2011)
Molecular profile NA Not reported NA NA Mines MA , et al. (2010)
Molecular profile Protein expression level evidence No change Immunohistochemistry 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry 2.5 - 6 months Dahlhaus R and El-Husseini A (2009)
Molecular profile NA Not reported NA NA Eadie BD , et al. (2009)
Molecular profile NA Not reported NA NA Schtt J , et al. (2009)
Molecular profile Transcriptome diversity No change Gene expression microarray Unreported Gantois I , et al. (2005)
Molecular profile Transcriptome diversity No change Quantitative pcr (qrt-pcr) Unreported Gantois I , et al. (2005)
Molecular profile Regulation of translation No change Quantitative pcr (qrt-pcr) Unreported Gantois I , et al. (2005)
Molecular profile Regulation of translation No change Semi-quantitative pcr (qrt-pcr) Unreported Gantois I , et al. (2005)
Molecular profile Protein expression: in situ protein expression No change Immunohistochemistry 4 months Gantois I , et al. (2005)
Molecular profile Protein expression: in situ protein expression No change Immunohistochemistry 4 months Gantois I , et al. (2005)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry 10 weeks Gantois I , et al. (2005)
Molecular profile Gene expression Abnormal Semi-quantitative pcr (qrt-pcr) 10-11 weeks Gantois I , et al. (2005)
Molecular profile Gene expression Increased Quantitative pcr (qrt-pcr) 9-13 weeks Gantois I , et al. (2005)
Molecular profile Gene expression Decreased Differential display analysis of hippocampus 9-13 weeks Gantois I , et al. (2005)

M_FMR1_1_KO_HM_5HT2BAG+D1AG+PI3KINHIBITOR

Model Type: Pharmaceutical intervention
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. A cocktail of 5HT and Dopamine receptor agonist and antagonist was coadministered. The 5HT 2B-R agonist BW723C86 (0.05mg/kg) and 5HT 2A-R-Antagonist MDL11939 (0.01mg/kg)The D1- R agonist SKF81297 (0.05mg/kg) and D2-R antagonist Sulpiride (0.25mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology NA Not reported NA NA Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion NA Not reported NA NA Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory Reward reinforced choice behavior Decreased Y-maze test P29 Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test P29 Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile NA Not reported NA NA Lim CS , et al. (2014)

M_FMR1_1_KO_HM_5HT2BAG-CA1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. The 5HT 2B-R agonist BW723C86 (5mg/kg) and 5HT 2A-R-Antagonist MDL11939 (1mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology Rectification of ion channels Ameliorated Whole-cell patch clamp P14, p29 Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion Anxiety Side effect Elevated plus maze test P29 Lim CS , et al. (2014)
Emotion Anxiety Side effect Light-dark exploration test P29 Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory Reward reinforced choice behavior Ameliorated Y-maze test P29 Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Ameliorated Fear conditioning test P29 Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile Protein modification process Ameliorated Western blot P14, p29 Lim CS , et al. (2014)
Molecular profile Protein modification process Ameliorated Western blot P14, p29 Lim CS , et al. (2014)

M_FMR1_1_KO_HM_5HT2BAG-L2-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the barrel cortex. s to achieve expression in one third of the CA1 pyramidal neurons. The 5HT 2B-R agonist BW723C86 (5mg/kg) and 5HT 2A-R-Antagonist MDL11939 (1mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection. The compounds were dissolved in saline and saline was given to vehicle controls.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology Rectification of ion channels Ameliorated Whole-cell patch clamp P14, p29 Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion NA Not reported NA NA Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory NA Not reported NA NA Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile NA Not reported NA NA Lim CS , et al. (2014)

M_FMR1_1_KO_HM_5HT2BAG_D1AG

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. A cocktail of 5HT and Dopamine receptor agonist and antagonist was coadministered. The 5HT 2B-R agonist BW723C86 (0.05mg/kg) and 5HT 2A-R-Antagonist MDL11939 (0.01mg/kg)The D1- R agonist SKF81297 (0.05mg/kg) and D2-R antagonist Sulpiride (0.25mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology Rectification of ion channels Ameliorated Whole-cell patch clamp Unreported Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion Anxiety No adverse effect Elevated plus maze test P29 Lim CS , et al. (2014)
Emotion Anxiety No adverse effect Light-dark exploration test P29 Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory Reward reinforced choice behavior Restored Y-maze test P29 Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Restored Fear conditioning test P29 Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile Signaling Ameliorated Western blot P14, p29 Lim CS , et al. (2014)
Molecular profile Protein modification process Restored Western blot P14 or 29 Lim CS , et al. (2014)

M_FMR1_1_KO_HM_APP

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Homologous recombination mediated deletion of exon 5 of FMR1 gene crossed with App heterozygote knockouts.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Westmark CJ , et al. (2011)
Circadian sleep/wake cycle NA Not reported NA NA Westmark CJ , et al. (2011)
Motor phenotype General locomotor activity Restored Open field test NA Westmark CJ , et al. (2011)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Westmark CJ , et al. (2011)
Neurophysiology Synaptic plasticity Restored Field potential recordings 3 months Westmark CJ , et al. (2011)
Neurophysiology Presynaptic function: paired-pulse facilitation No adverse effect Paired-pulse ratio Unreported Westmark CJ , et al. (2011)
Repetitive behavior Repetitive digging Restored Marble-burying test 8-10 weeks Westmark CJ , et al. (2011)
Seizure Seizures Ameliorated Audiogenic seizure test P21 Westmark CJ , et al. (2011)
Sensory NA Not reported NA NA Westmark CJ , et al. (2011)
Social behavior NA Not reported NA NA Westmark CJ , et al. (2011)
Communications NA Not reported NA NA Westmark CJ , et al. (2011)
Developmental profile NA Not reported NA NA Westmark CJ , et al. (2011)
Emotion NA Not reported NA NA Westmark CJ , et al. (2011)
Immune response NA Not reported NA NA Westmark CJ , et al. (2011)
Learning & memory NA Not reported NA NA Westmark CJ , et al. (2011)
Maternal behavior NA Not reported NA NA Westmark CJ , et al. (2011)
Molecular profile Protein expression level evidence Restored Western blot 1 month Westmark CJ , et al. (2011)

M_FMR1_1_KO_HM_CTEP_A

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination mediated targeting against Exon 5 of FMR1 followed by acute treatment of CTEP of 2 mg/kg per os (s.c.) 24 hr prior.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Michalon A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Michalon A , et al. (2012)
Motor phenotype NA Not reported NA NA Michalon A , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Michalon A , et al. (2012)
Neurophysiology Synaptic plasticity: ltd Restored Field potential recordings P25-p30 Michalon A , et al. (2012)
Repetitive behavior NA Not reported NA NA Michalon A , et al. (2012)
Seizure Seizures Restored Acoustic startle reflex test P18-p22 Michalon A , et al. (2012)
Seizure Seizures Ameliorated Acoustic startle reflex test 1-2 months Michalon A , et al. (2012)
Sensory NA Not reported NA NA Michalon A , et al. (2012)
Social behavior NA Not reported NA NA Michalon A , et al. (2012)
Communications NA Not reported NA NA Michalon A , et al. (2012)
Developmental profile NA Not reported NA NA Michalon A , et al. (2012)
Emotion NA Not reported NA NA Michalon A , et al. (2012)
Immune response NA Not reported NA NA Michalon A , et al. (2012)
Learning & memory NA Not reported NA NA Michalon A , et al. (2012)
Maternal behavior NA Not reported NA NA Michalon A , et al. (2012)
Molecular profile NA Not reported NA NA Michalon A , et al. (2012)

M_FMR1_1_KO_HM_CTEP_C

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination mediated targeting against Exon 5 of FMR1 followed by chronic treatment of CTEP.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Michalon A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Michalon A , et al. (2012)
Motor phenotype Motor coordination and balance No adverse effect Accelerating rotarod test Unreported Michalon A , et al. (2012)
Motor phenotype Grip strength Refractory Grip strength test 9 weeks Michalon A , et al. (2012)
Motor phenotype General locomotor activity Restored Open field test 2-5 months Michalon A , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Golgi-cox staining P58-p63 Michalon A , et al. (2012)
Neurophysiology Synaptic plasticity Restored Field potential recordings P58-p65 Michalon A , et al. (2012)
Repetitive behavior NA Not reported NA NA Michalon A , et al. (2012)
Seizure NA Not reported NA NA Michalon A , et al. (2012)
Sensory Startle response: acoustic stimulus Restored Acoustic startle reflex test P58-p63 Michalon A , et al. (2012)
Social behavior NA Not reported NA NA Michalon A , et al. (2012)
Communications NA Not reported NA NA Michalon A , et al. (2012)
Developmental profile Tissue weight Ameliorated General observations 5-17 weeks Michalon A , et al. (2012)
Developmental profile Size/growth Side effect General observations Unreported Michalon A , et al. (2012)
Developmental profile Developmental trajectory Restored Irwin battery of neurological tests 9 weeks Michalon A , et al. (2012)
Emotion NA Not reported NA NA Michalon A , et al. (2012)
Immune response NA Not reported NA NA Michalon A , et al. (2012)
Learning & memory Cued or contextual fear conditioning: memory of cue Restored Passive avoidance test P58-p63 Michalon A , et al. (2012)
Maternal behavior NA Not reported NA NA Michalon A , et al. (2012)
Molecular profile Signaling Restored Western blot P58-p63 Michalon A , et al. (2012)

M_FMR1_1_KO_HM_CX

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or 5 mg/kg of CX-4945 dissolved in DMSO, and diluted 1:10 into cyclodextrin. CX-4945 is an inhibitor of the kinase that activates Brd4, casein kinase 2 (CK2).

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Korb E , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Ameliorated Open field test 4-8 weeks Korb E , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Korb E , et al. (2017)
Neurophysiology NA Not reported NA NA Korb E , et al. (2017)
Repetitive behavior Repetitive digging Refractory Marble-burying test 4-8 weeks Korb E , et al. (2017)
Seizure NA Not reported NA NA Korb E , et al. (2017)
Sensory NA Not reported NA NA Korb E , et al. (2017)
Social behavior Social approach Refractory Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Communications NA Not reported NA NA Korb E , et al. (2017)
Developmental profile NA Not reported NA NA Korb E , et al. (2017)
Emotion Anxiety Refractory Open field test 5 weeks Korb E , et al. (2017)
Immune response NA Not reported NA NA Korb E , et al. (2017)
Learning & memory NA Not reported NA NA Korb E , et al. (2017)
Maternal behavior NA Not reported NA NA Korb E , et al. (2017)
Molecular profile Gene expression Refractory Quantitative pcr (qrt-pcr) 4-8 weeks Korb E , et al. (2017)

M_FMR1_1_KO_HM_D1AGONIST-CA1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. The D1- R agonist SKF81297 (5mg/kg) and D2-R antagonist Sulpiride (25mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology Rectification of ion channels Ameliorated Whole-cell patch clamp P14, p29 Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion NA Not reported NA NA Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory Reward reinforced choice behavior Ameliorated Y-maze test P29 Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Ameliorated Fear conditioning test P29 Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile Protein modification process Ameliorated Western blot P14, p29 Lim CS , et al. (2014)
Molecular profile Protein modification process Ameliorated Western blot P14, p29 Lim CS , et al. (2014)

M_FMR1_1_KO_HM_D1AGONIST-L2-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the barrel cortex. T The D1- R agonist SKF81297 (5mg/kg) and D2-R antagonist Sulpiride (25mg/kg) were administered by four i.p. injections spaced by 4-6 h. To determine the role of the PI3K/PKB signaling pathway a PI3K inhibitor LY294002 was administered at a dose of 5mg/kg. The administration started 4-10 h before the viral injection. The compounds were dissolved in saline and saline was given to vehicle controls.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology Rectification of ion channels Ameliorated Whole-cell patch clamp P14, p29 Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion NA Not reported NA NA Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory NA Not reported NA NA Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile NA Not reported NA NA Lim CS , et al. (2014)

M_FMR1_1_KO_HM_GLUA1CT-5HT2BAG+D1AG

Model Type: Pharmaceutical intervention
Model Genotype: Homozygous

Mutation:

Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1ct-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. The GluA!ct is a GFP taged cytiplasmic domain of GluA1 receptor subunit that acts as a dominant negative construct selectively blocking synaptic trafficking of endogenous or viral GluA1 contianing AMPA-rs.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Lim CS , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Lim CS , et al. (2014)
Motor phenotype NA Not reported NA NA Lim CS , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Lim CS , et al. (2014)
Neurophysiology NA Not reported NA NA Lim CS , et al. (2014)
Repetitive behavior NA Not reported NA NA Lim CS , et al. (2014)
Seizure NA Not reported NA NA Lim CS , et al. (2014)
Sensory NA Not reported NA NA Lim CS , et al. (2014)
Social behavior NA Not reported NA NA Lim CS , et al. (2014)
Communications NA Not reported NA NA Lim CS , et al. (2014)
Developmental profile NA Not reported NA NA Lim CS , et al. (2014)
Emotion NA Not reported NA NA Lim CS , et al. (2014)
Immune response NA Not reported NA NA Lim CS , et al. (2014)
Learning & memory Reward reinforced choice behavior Decreased Y-maze test P29 Lim CS , et al. (2014)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test P29 Lim CS , et al. (2014)
Maternal behavior NA Not reported NA NA Lim CS , et al. (2014)
Molecular profile NA Not reported NA NA Lim CS , et al. (2014)

M_FMR1_1_KO_HM_IL17A-S1DZ

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Recombinant IL17a protein (50 ng per side in 1 microliter at a rate of 180 nl/min, 7956-ML/CF, R&D) was administered directly and bilaterally into the primary somatosensory cortex dysgranular zone in adult male Fmr1 mutant four hours before testing.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J

Es cell line: E14
Model Source: The Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neurophysiology NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social approach Restored Three-chamber social approach test Adult ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion NA Not reported NA NA ()
Immune response NA Not reported NA NA ()
Learning & memory NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_FMR1_1_KO_HM_JQ1-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or JQ1 at 5 mg/kg, dissolved in DMSO, and diluted 1:10 into cyclodextrin.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Korb E , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Ameliorated Open field test 4-8 weeks Korb E , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Korb E , et al. (2017)
Neurophysiology NA Not reported NA NA Korb E , et al. (2017)
Repetitive behavior Repetitive digging Ameliorated Marble-burying test 4-8 weeks Korb E , et al. (2017)
Seizure NA Not reported NA NA Korb E , et al. (2017)
Sensory NA Not reported NA NA Korb E , et al. (2017)
Social behavior Social approach Refractory Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Communications NA Not reported NA NA Korb E , et al. (2017)
Developmental profile NA Not reported NA NA Korb E , et al. (2017)
Emotion Anxiety Refractory Open field test 5 weeks Korb E , et al. (2017)
Immune response NA Not reported NA NA Korb E , et al. (2017)
Learning & memory NA Not reported NA NA Korb E , et al. (2017)
Maternal behavior NA Not reported NA NA Korb E , et al. (2017)
Molecular profile Gene expression Ameliorated Quantitative pcr (qrt-pcr) 4-8 weeks Korb E , et al. (2017)

M_FMR1_1_KO_HM_JQ1-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or JQ1 at 25 mg/kg dissolved in DMSO, and diluted 1:10 into cyclodextrin.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Korb E , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Restored Open field test 4-8 weeks Korb E , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Korb E , et al. (2017)
Neurophysiology NA Not reported NA NA Korb E , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 4-8 weeks Korb E , et al. (2017)
Seizure NA Not reported NA NA Korb E , et al. (2017)
Sensory NA Not reported NA NA Korb E , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Communications NA Not reported NA NA Korb E , et al. (2017)
Developmental profile Integumentary system development No adverse effect Immunohistochemistry Not specified Korb E , et al. (2017)
Developmental profile Digestive system development No adverse effect Immunohistochemistry Not specified Korb E , et al. (2017)
Emotion Exploratory activity No adverse effect Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Emotion Anxiety No adverse effect Open field test 4-8 weeks Korb E , et al. (2017)
Immune response Adaptive immune response: t cells No adverse effect Flow cytometric analysis Not specified Korb E , et al. (2017)
Learning & memory Object recognition memory Ameliorated Novel object recognition test 4-8 weeks Korb E , et al. (2017)
Maternal behavior NA Not reported NA NA Korb E , et al. (2017)
Molecular profile NA Not reported NA NA Korb E , et al. (2017)

M_FMR1_1_KO_HM_JQ1-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone (controls) or JQ1 at 50 mg/kg dissolved in DMSO, and diluted 1:10 into cyclodextrin.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Korb E , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Three-chamber social approach test 4.3 weeks Korb E , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Korb E , et al. (2017)
Neurophysiology NA Not reported NA NA Korb E , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 4.3 weeks Korb E , et al. (2017)
Seizure NA Not reported NA NA Korb E , et al. (2017)
Sensory NA Not reported NA NA Korb E , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 4.3 weeks Korb E , et al. (2017)
Communications NA Not reported NA NA Korb E , et al. (2017)
Developmental profile Integumentary system development Side effect Immunohistochemistry Not specified Korb E , et al. (2017)
Developmental profile Digestive system development No adverse effect Immunohistochemistry Not specified Korb E , et al. (2017)
Emotion Exploratory activity No adverse effect Three-chamber social approach test 4.3 weeks Korb E , et al. (2017)
Immune response Adaptive immune response: t cells Side effect Flow cytometric analysis Not specified Korb E , et al. (2017)
Learning & memory NA Not reported NA NA Korb E , et al. (2017)
Maternal behavior NA Not reported NA NA Korb E , et al. (2017)
Molecular profile Gene expression Ameliorated Quantitative pcr (qrt-pcr) Not specified Korb E , et al. (2017)

M_FMR1_1_KO_HM_JQ1_CX

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or 5 mg/kg each of JQ1 and CX-4945 combined, dissolved in DMSO, and diluted 1:10 into cyclodextrin.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Korb E , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Refractory Open field test 4-8 weeks Korb E , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Refractory Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Immunohistochemistry 4-8 weeks Korb E , et al. (2017)
Neurophysiology NA Not reported NA NA Korb E , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 4-8 weeks Korb E , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 4-8 weeks Korb E , et al. (2017)
Seizure NA Not reported NA NA Korb E , et al. (2017)
Sensory NA Not reported NA NA Korb E , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 4-8 weeks Korb E , et al. (2017)
Communications NA Not reported NA NA Korb E , et al. (2017)
Developmental profile NA Not reported NA NA Korb E , et al. (2017)
Emotion Anxiety Restored Open field test 5 weeks Korb E , et al. (2017)
Immune response NA Not reported NA NA Korb E , et al. (2017)
Learning & memory NA Not reported NA NA Korb E , et al. (2017)
Maternal behavior NA Not reported NA NA Korb E , et al. (2017)
Molecular profile Gene expression Ameliorated Quantitative pcr (qrt-pcr) 4-8 weeks Korb E , et al. (2017)
Molecular profile Gene expression Restored Quantitative pcr (qrt-pcr) 4-8 weeks Korb E , et al. (2017)

M_FMR1_1_KO_HM_LITHIUM-ACUTE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 KO mice were given an intraperitoneal (ip) injection of 4 mmole/kg lithium chloride (Sigma), for the acute treatment with lithium a dose that is effective in behavioral tests and increases serinephosphorylation of GSK3 in mouse brain.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Motor phenotype NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Neurophysiology NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Repetitive behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Seizure NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Sensory NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Social behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Communications NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Developmental profile NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Emotion NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Immune response NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Learning & memory NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Maternal behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Sustained effect Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Sustained effect Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Sustained effect Western blot 3 months Yuskaitis CJ , et al. (2009)

M_FMR1_1_KO_HM_LITHIUM-CHRONIC

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 KO mice were given water and saline ad libitum and were fed pelleted chow containing 0.2% lithium carbonate (Teklad, Madison, WI) for three weeks for the chronic treatment with lithium.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Motor phenotype NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Neurophysiology Neurotransmitter release: neurotrophins Unexpected results Elisa 3 months Yuskaitis CJ , et al. (2009)
Repetitive behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Seizure NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Sensory NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Social behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Communications NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Developmental profile NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Emotion NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Immune response NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Learning & memory Cued or contextual fear conditioning: passive avoidance Restored Passive avoidance test 3 months Yuskaitis CJ , et al. (2009)
Maternal behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)

M_FMR1_1_KO_HM_LPS

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous; hemizygous

Mutation:

FMR1 mutant mice were treated with lipopolysaccharide (50microgram/kg, i.p., acute)

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J

Es cell line: E14
Model Source: The Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neurophysiology Neuronal activation Refractory Immunohistochemistry Adult ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social approach Refractory Three-chamber social approach test Adult ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion NA Not reported NA NA ()
Immune response Cytokine levels: pro-inflammatory Side effect Elisa Adult, 2-5 months, 9-12 months ()
Learning & memory NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_FMR1_1_KO_HM_MINOCYCLINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo) with 30 mg/kg minocycline mother's drinking water for 28 days.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: Not Specified

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Rotschafer SE , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Rotschafer SE , et al. (2012)
Motor phenotype NA Not reported NA NA Rotschafer SE , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Rotschafer SE , et al. (2012)
Neurophysiology NA Not reported NA NA Rotschafer SE , et al. (2012)
Repetitive behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Seizure NA Not reported NA NA Rotschafer SE , et al. (2012)
Sensory NA Not reported NA NA Rotschafer SE , et al. (2012)
Social behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Communications Ultrasonic vocalization Restored Monitoring ultrasonic vocalizations NA Rotschafer SE , et al. (2012)
Communications Ultrasonic vocalization No adverse effect Monitoring ultrasonic vocalizations Unreported Rotschafer SE , et al. (2012)
Developmental profile NA Not reported NA NA Rotschafer SE , et al. (2012)
Emotion NA Not reported NA NA Rotschafer SE , et al. (2012)
Immune response NA Not reported NA NA Rotschafer SE , et al. (2012)
Learning & memory NA Not reported NA NA Rotschafer SE , et al. (2012)
Maternal behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Molecular profile NA Not reported NA NA Rotschafer SE , et al. (2012)

M_FMR1_1_KO_HM_MINOCYCLINE-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo) with 30 mg/kg minocycline mother's drinking water for 28 days.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: Not Specified

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Rotschafer SE , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Rotschafer SE , et al. (2012)
Motor phenotype NA Not reported NA NA Rotschafer SE , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Rotschafer SE , et al. (2012)
Neurophysiology NA Not reported NA NA Rotschafer SE , et al. (2012)
Repetitive behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Seizure NA Not reported NA NA Rotschafer SE , et al. (2012)
Sensory NA Not reported NA NA Rotschafer SE , et al. (2012)
Social behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Communications Ultrasonic vocalization Restored Monitoring ultrasonic vocalizations NA Rotschafer SE , et al. (2012)
Communications Ultrasonic vocalization No adverse effect Monitoring ultrasonic vocalizations Unreported Rotschafer SE , et al. (2012)
Developmental profile NA Not reported NA NA Rotschafer SE , et al. (2012)
Emotion NA Not reported NA NA Rotschafer SE , et al. (2012)
Immune response NA Not reported NA NA Rotschafer SE , et al. (2012)
Learning & memory NA Not reported NA NA Rotschafer SE , et al. (2012)
Maternal behavior NA Not reported NA NA Rotschafer SE , et al. (2012)
Molecular profile NA Not reported NA NA Rotschafer SE , et al. (2012)

M_FMR1_1_KO_HM_MINOCYCLINE-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous

Mutation:

Female FMR1 heterozygous mice and their pups were treated with minocycline through drinking water at 30mg/kg/day. After the offspring were weaned, minocycline administration continued in the drinking water of the offspring until they reached 2 months of age. FMR1 hemizygous knockout mice where a neomycin resistance gene is inserted into exon 5 and there is no detectable transcript or protein produced by this allele. .

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J

Es cell line: E14
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Yau SY , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Yau SY , et al. (2018)
Motor phenotype NA Not reported NA NA Yau SY , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: nmda receptors Restored Western blot Adult Yau SY , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Restored Sholl analysis Adult Yau SY , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Restored Sholl analysis Adult Yau SY , et al. (2018)
Neurophysiology Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission Restored Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: excitatory Restored Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: excitatory No adverse effect Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Epsp-spike relationship Restored Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Neurophysiology Epsp-spike relationship Side effect Whole-cell voltage clamp Adult Yau SY , et al. (2018)
Repetitive behavior NA Not reported NA NA Yau SY , et al. (2018)
Seizure NA Not reported NA NA Yau SY , et al. (2018)
Sensory NA Not reported NA NA Yau SY , et al. (2018)
Social behavior NA Not reported NA NA Yau SY , et al. (2018)
Communications NA Not reported NA NA Yau SY , et al. (2018)
Developmental profile NA Not reported NA NA Yau SY , et al. (2018)
Emotion Exploratory activity: habituation No adverse effect Object-place recognition test Adult Yau SY , et al. (2018)
Emotion Depression No adverse effect Forced swim test Adult Yau SY , et al. (2018)
Emotion Depression No adverse effect Tail suspension test Adult Yau SY , et al. (2018)
Emotion Anxiety Side effect Open field test Adult Yau SY , et al. (2018)
Immune response NA Not reported NA NA Yau SY , et al. (2018)
Learning & memory Spatial reference memory Restored Object-place recognition test Adult Yau SY , et al. (2018)
Learning & memory Procedural learning No adverse effect Novel object recognition test Adult Yau SY , et al. (2018)
Learning & memory Object recognition memory Restored Novel object recognition test Adult Yau SY , et al. (2018)
Maternal behavior NA Not reported NA NA Yau SY , et al. (2018)
Molecular profile Protein phosphorylation Restored Western blot Adult Yau SY , et al. (2018)
Molecular profile Protein localization: synapse Restored Western blot Adult Yau SY , et al. (2018)

M_FMR1_1_KO_HM_MPEP

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

FMR1 KO mice were given an intraperitoneal (ip) injection of 30mg/kg MPEP (2-methyl-6-phenylethynyl-pyridine), for the acute treatment with lithium a dose that is effective in behavioral tests and increases serinephosphorylation of GSK3 in mouse brain.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Motor phenotype NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Neurophysiology NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Repetitive behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Seizure NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Sensory NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Social behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Communications NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Developmental profile NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Emotion NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Immune response NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Learning & memory NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Maternal behavior NA Not reported NA NA Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)
Molecular profile Protein phosphorylation Restored Western blot 3 months Yuskaitis CJ , et al. (2009)

M_FMR1_1_KO_HM_S1DZ-INACT

Model Type: RESCUE-Procedural
Model Genotype: Homozygous

Mutation:

Neural activity was optogenetically suppressed in the primary somatosensory cortex dysgranular zone in Fmr1 mutant mice.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J

Es cell line: E14
Model Source: The Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype NA Not reported NA NA ()
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA ()
Neurophysiology NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social approach Restored Three-chamber social approach test Adult ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion NA Not reported NA NA ()
Immune response NA Not reported NA NA ()
Learning & memory NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_FMR1_2_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

FMR1 gene was generated by construction a targeting vector using homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo).

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: Not Specified

Es cell line: E14
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA no authors (1994)
Physiological parameters NA Not reported NA NA Orefice LL , et al. (2016)
Physiological parameters NA Not reported NA NA Costa L , et al. (2012)
Physiological parameters NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Physiological parameters NA Not reported NA NA Shang Y , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA no authors (1994)
Circadian sleep/wake cycle NA Not reported NA NA Orefice LL , et al. (2016)
Circadian sleep/wake cycle NA Not reported NA NA Costa L , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Circadian sleep/wake cycle NA Not reported NA NA Shang Y , et al. (2009)
Motor phenotype Spontaneous movement Increased Home cage behavior Unreported no authors (1994)
Motor phenotype NA Not reported NA NA Orefice LL , et al. (2016)
Motor phenotype NA Not reported NA NA Costa L , et al. (2012)
Motor phenotype General locomotor activity No change Open field test 3 months Olmos-Serrano JL , et al. (2011)
Motor phenotype General locomotor activity Increased Open field test 3 months Olmos-Serrano JL , et al. (2011)
Motor phenotype NA Not reported NA NA Shang Y , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Macroscopic analysis 2 months no authors (1994)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Orefice LL , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Costa L , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Shang Y , et al. (2009)
Neurophysiology NA Not reported NA NA no authors (1994)
Neurophysiology NA Not reported NA NA Orefice LL , et al. (2016)
Neurophysiology Miniature post synaptic currents: excitatory Increased Whole-cell patch clamp P0-p1 Costa L , et al. (2012)
Neurophysiology Miniature post synaptic currents: excitatory Decreased Whole-cell patch clamp P0-p1 Costa L , et al. (2012)
Neurophysiology NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Neurophysiology Synaptic transmission Decreased Field potential recordings Unreported Shang Y , et al. (2009)
Repetitive behavior NA Not reported NA NA no authors (1994)
Repetitive behavior NA Not reported NA NA Orefice LL , et al. (2016)
Repetitive behavior NA Not reported NA NA Costa L , et al. (2012)
Repetitive behavior NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Repetitive behavior NA Not reported NA NA Shang Y , et al. (2009)
Seizure NA Not reported NA NA no authors (1994)
Seizure NA Not reported NA NA Orefice LL , et al. (2016)
Seizure NA Not reported NA NA Costa L , et al. (2012)
Seizure NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Seizure NA Not reported NA NA Shang Y , et al. (2009)
Sensory NA Not reported NA NA no authors (1994)
Sensory Touch Increased Response to air puff 6-8 weeks Orefice LL , et al. (2016)
Sensory Tactile memory Decreased Textured novel object recognition test (t-nort) 6-8 weeks Orefice LL , et al. (2016)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 6-8 weeks Orefice LL , et al. (2016)
Sensory Sensorimotor gating: tactile cue Decreased Prepulse inhibition 6-8 weeks Orefice LL , et al. (2016)
Sensory Sensorimotor gating No change Prepulse inhibition 6-8 weeks Orefice LL , et al. (2016)
Sensory NA Not reported NA NA Costa L , et al. (2012)
Sensory Startle response: acoustic stimulus Decreased Prepulse inhibition 3 months Olmos-Serrano JL , et al. (2011)
Sensory Startle response: acoustic stimulus Decreased Prepulse inhibition 3 months Olmos-Serrano JL , et al. (2011)
Sensory Sensorimotor gating No change Prepulse inhibition 3 months Olmos-Serrano JL , et al. (2011)
Sensory Sensorimotor gating Increased Prepulse inhibition 3 months Olmos-Serrano JL , et al. (2011)
Sensory NA Not reported NA NA Shang Y , et al. (2009)
Social behavior Social interaction No change Reciprocal social interaction test Unreported no authors (1994)
Social behavior Social interaction Increased Light-dark exploration test Unreported no authors (1994)
Social behavior NA Not reported NA NA Orefice LL , et al. (2016)
Social behavior NA Not reported NA NA Costa L , et al. (2012)
Social behavior NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Social behavior NA Not reported NA NA Shang Y , et al. (2009)
Communications NA Not reported NA NA no authors (1994)
Communications NA Not reported NA NA Orefice LL , et al. (2016)
Communications NA Not reported NA NA Costa L , et al. (2012)
Communications NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Communications NA Not reported NA NA Shang Y , et al. (2009)
Developmental profile Reproductive system development No change General observations Unreported no authors (1994)
Developmental profile Reproductive system development Decreased General observations 5-7 weeks, 2.5 months; 3.5 months; 5.5 months no authors (1994)
Developmental profile Reproductive system development Decreased Histology 5-7 weeks, 2.5 months; 3.5 months; 5.5 months no authors (1994)
Developmental profile NA Not reported NA NA Orefice LL , et al. (2016)
Developmental profile NA Not reported NA NA Costa L , et al. (2012)
Developmental profile NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Developmental profile NA Not reported NA NA Shang Y , et al. (2009)
Emotion NA Not reported NA NA no authors (1994)
Emotion Exploratory activity No change Textured novel object recognition test (t-nort) 6-8 weeks Orefice LL , et al. (2016)
Emotion NA Not reported NA NA Costa L , et al. (2012)
Emotion Anxiety No change Open field test 3 months Olmos-Serrano JL , et al. (2011)
Emotion NA Not reported NA NA Shang Y , et al. (2009)
Immune response NA Not reported NA NA no authors (1994)
Immune response NA Not reported NA NA Orefice LL , et al. (2016)
Immune response NA Not reported NA NA Costa L , et al. (2012)
Immune response NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Immune response NA Not reported NA NA Shang Y , et al. (2009)
Learning & memory Spatial learning No change Morris water maze test Unreported no authors (1994)
Learning & memory Spatial learning Decreased Morris water maze test Unreported no authors (1994)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Passive avoidance test Unreported no authors (1994)
Learning & memory Object recognition memory: long-term recall Decreased Novel object recognition test 6-8 weeks Orefice LL , et al. (2016)
Learning & memory Object recognition memory No change Novel object recognition test 6-8 weeks Orefice LL , et al. (2016)
Learning & memory NA Not reported NA NA Costa L , et al. (2012)
Learning & memory Cued or contextual fear conditioning: memory of cue Decreased Fear conditioning test 3 months Olmos-Serrano JL , et al. (2011)
Learning & memory Cued or contextual fear conditioning: memory of cue Decreased Fear conditioning test 3 months Olmos-Serrano JL , et al. (2011)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 3 months Olmos-Serrano JL , et al. (2011)
Learning & memory NA Not reported NA NA Shang Y , et al. (2009)
Maternal behavior NA Not reported NA NA no authors (1994)
Maternal behavior NA Not reported NA NA Orefice LL , et al. (2016)
Maternal behavior NA Not reported NA NA Costa L , et al. (2012)
Maternal behavior NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Maternal behavior NA Not reported NA NA Shang Y , et al. (2009)
Molecular profile NA Not reported NA NA no authors (1994)
Molecular profile NA Not reported NA NA Orefice LL , et al. (2016)
Molecular profile NA Not reported NA NA Costa L , et al. (2012)
Molecular profile NA Not reported NA NA Olmos-Serrano JL , et al. (2011)
Molecular profile NA Not reported NA NA Shang Y , et al. (2009)

M_FMR1_2_KO_HM_CTEP-A

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination mediated targeting against Exon 5 of Fmr1 followed by acute treatment of CTEP of 2 mg/kg per os (s.c.) 24 hr prior.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Michalon A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Michalon A , et al. (2012)
Motor phenotype NA Not reported NA NA Michalon A , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Michalon A , et al. (2012)
Neurophysiology Synaptic plasticity: ltd Restored Field potential recordings P25-p30 Michalon A , et al. (2012)
Repetitive behavior NA Not reported NA NA Michalon A , et al. (2012)
Seizure Seizures Restored Acoustic startle reflex test P18-p22 Michalon A , et al. (2012)
Seizure Seizures Ameliorated Acoustic startle reflex test 1-2 months Michalon A , et al. (2012)
Sensory NA Not reported NA NA Michalon A , et al. (2012)
Social behavior NA Not reported NA NA Michalon A , et al. (2012)
Communications NA Not reported NA NA Michalon A , et al. (2012)
Developmental profile NA Not reported NA NA Michalon A , et al. (2012)
Emotion NA Not reported NA NA Michalon A , et al. (2012)
Immune response NA Not reported NA NA Michalon A , et al. (2012)
Learning & memory NA Not reported NA NA Michalon A , et al. (2012)
Maternal behavior NA Not reported NA NA Michalon A , et al. (2012)
Molecular profile NA Not reported NA NA Michalon A , et al. (2012)

M_FMR1_2_KO_HM_CTEP-C

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination mediated targeting against Exon 5 of Fmr1 followed by chronic treatment of CTEP.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Michalon A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Michalon A , et al. (2012)
Motor phenotype Motor coordination and balance No adverse effect Accelerating rotarod test Unreported Michalon A , et al. (2012)
Motor phenotype Grip strength Refractory Grip strength test 9 weeks Michalon A , et al. (2012)
Motor phenotype General locomotor activity Restored Open field test 2-5 months Michalon A , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Golgi-cox staining P58-p63 Michalon A , et al. (2012)
Neurophysiology Synaptic plasticity Restored Field potential recordings P58-p65 Michalon A , et al. (2012)
Repetitive behavior NA Not reported NA NA Michalon A , et al. (2012)
Seizure NA Not reported NA NA Michalon A , et al. (2012)
Sensory Startle response: acoustic stimulus Restored Acoustic startle reflex test P58-p63 Michalon A , et al. (2012)
Social behavior NA Not reported NA NA Michalon A , et al. (2012)
Communications NA Not reported NA NA Michalon A , et al. (2012)
Developmental profile Tissue weight Ameliorated General observations 5-17 weeks Michalon A , et al. (2012)
Developmental profile Size/growth Side effect General observations Unreported Michalon A , et al. (2012)
Developmental profile Developmental trajectory Restored Irwin battery of neurological tests 9 weeks Michalon A , et al. (2012)
Emotion NA Not reported NA NA Michalon A , et al. (2012)
Immune response NA Not reported NA NA Michalon A , et al. (2012)
Learning & memory Cued or contextual fear conditioning: memory of cue Restored Passive avoidance test P58-p63 Michalon A , et al. (2012)
Maternal behavior NA Not reported NA NA Michalon A , et al. (2012)
Molecular profile Signaling Restored Western blot P58-p63 Michalon A , et al. (2012)

M_FMR1_3_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

A germline null mutation was created by crossing FMR1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Gene inactivation was confirmed by a lack of protein expression in the brain and testes as determined by immunoblot analysis.

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: 129P2/OlaHsd * C57BL/6

Es cell line: E14
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Tyzio R , et al. (2014)
Physiological parameters NA Not reported NA NA Mientjes EJ , et al. (2005)
Circadian sleep/wake cycle NA Not reported NA NA Tyzio R , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Mientjes EJ , et al. (2005)
Motor phenotype NA Not reported NA NA Tyzio R , et al. (2014)
Motor phenotype NA Not reported NA NA Mientjes EJ , et al. (2005)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neurotransporter expression Decreased Immunocytochemistry P15 Tyzio R , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Mientjes EJ , et al. (2005)
Neurophysiology Spontaneous post synaptic events Increased Whole-cell patch clamp P0, p15 Tyzio R , et al. (2014)
Neurophysiology Population spikes Increased Field potential recordings P15 Tyzio R , et al. (2014)
Neurophysiology Driving force of ion channel or receptor Increased Cell-attached patch clamp E20-e21, p15, p30 Tyzio R , et al. (2014)
Neurophysiology Action potential property: firing rate Increased Cell-attached patch clamp P0 Tyzio R , et al. (2014)
Neurophysiology NA Not reported NA NA Mientjes EJ , et al. (2005)
Repetitive behavior NA Not reported NA NA Tyzio R , et al. (2014)
Repetitive behavior NA Not reported NA NA Mientjes EJ , et al. (2005)
Seizure NA Not reported NA NA Tyzio R , et al. (2014)
Seizure NA Not reported NA NA Mientjes EJ , et al. (2005)
Sensory NA Not reported NA NA Tyzio R , et al. (2014)
Sensory NA Not reported NA NA Mientjes EJ , et al. (2005)
Social behavior NA Not reported NA NA Tyzio R , et al. (2014)
Social behavior NA Not reported NA NA Mientjes EJ , et al. (2005)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations P8 Tyzio R , et al. (2014)
Communications NA Not reported NA NA Mientjes EJ , et al. (2005)
Developmental profile NA Not reported NA NA Tyzio R , et al. (2014)
Developmental profile Reproductive system development Decreased Measurement of tissue weight Unreported Mientjes EJ , et al. (2005)
Developmental profile General characteristics No change General observations Unreported Mientjes EJ , et al. (2005)
Developmental profile General characteristics No change General observations Unreported Mientjes EJ , et al. (2005)
Emotion NA Not reported NA NA Tyzio R , et al. (2014)
Emotion NA Not reported NA NA Mientjes EJ , et al. (2005)
Immune response NA Not reported NA NA Tyzio R , et al. (2014)
Immune response NA Not reported NA NA Mientjes EJ , et al. (2005)
Learning & memory NA Not reported NA NA Tyzio R , et al. (2014)
Learning & memory NA Not reported NA NA Mientjes EJ , et al. (2005)
Maternal behavior NA Not reported NA NA Tyzio R , et al. (2014)
Maternal behavior NA Not reported NA NA Mientjes EJ , et al. (2005)
Molecular profile NA Not reported NA NA Tyzio R , et al. (2014)
Molecular profile Targeted expression Decreased Immunocytochemistry Unreported Mientjes EJ , et al. (2005)
Molecular profile Targeted expression Decreased Western blot Unreported Mientjes EJ , et al. (2005)
Molecular profile Targeted expression Decreased Quantitative pcr (qrt-pcr) Unreported Mientjes EJ , et al. (2005)

M_FMR1_3_KO_HM-BUMETANIDE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

A germline null mutation was created by crossing FMR1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Dams were treated with Bumetanide (2-2.5 mg/kg) in drinking water, one day before delivery.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: 129P2/OlaHsd * C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Tyzio R , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Tyzio R , et al. (2014)
Motor phenotype NA Not reported NA NA Tyzio R , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Tyzio R , et al. (2014)
Neurophysiology Spontaneous post synaptic events Ameliorated Whole-cell patch clamp P15 Tyzio R , et al. (2014)
Neurophysiology Population spikes Ameliorated Field potential recordings P15 Tyzio R , et al. (2014)
Neurophysiology Driving force of ion channel or receptor Restored Cell-attached patch clamp P15 Tyzio R , et al. (2014)
Repetitive behavior NA Not reported NA NA Tyzio R , et al. (2014)
Seizure NA Not reported NA NA Tyzio R , et al. (2014)
Sensory NA Not reported NA NA Tyzio R , et al. (2014)
Social behavior NA Not reported NA NA Tyzio R , et al. (2014)
Communications Ultrasonic vocalization Restored Monitoring ultrasonic vocalizations P8 Tyzio R , et al. (2014)
Developmental profile NA Not reported NA NA Tyzio R , et al. (2014)
Emotion NA Not reported NA NA Tyzio R , et al. (2014)
Immune response NA Not reported NA NA Tyzio R , et al. (2014)
Learning & memory NA Not reported NA NA Tyzio R , et al. (2014)
Maternal behavior NA Not reported NA NA Tyzio R , et al. (2014)
Molecular profile NA Not reported NA NA Tyzio R , et al. (2014)

M_FMR1_3_KO_HM_BUMETANIDE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

A germline null mutation was created by crossing Fmr1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Dams were treated with Bumetanide (2-2.5 mg/kg) in drinking water, one day before delivery.

Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: 129P2/OlaHsd * C57BL/6

Es cell line: -
Model Source: JAX
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Tyzio R , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Tyzio R , et al. (2014)
Motor phenotype NA Not reported NA NA Tyzio R , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Tyzio R , et al. (2014)
Neurophysiology Spontaneous post synaptic events Ameliorated Whole-cell patch clamp P15 Tyzio R , et al. (2014)
Neurophysiology Population spikes Ameliorated Field potential recordings P15 Tyzio R , et al. (2014)
Neurophysiology Driving force of ion channel or receptor Restored Cell-attached patch clamp P15 Tyzio R , et al. (2014)
Repetitive behavior NA Not reported NA NA Tyzio R , et al. (2014)
Seizure NA Not reported NA NA Tyzio R , et al. (2014)
Sensory NA Not reported NA NA Tyzio R , et al. (2014)
Social behavior NA Not reported NA NA Tyzio R , et al. (2014)
Communications Ultrasonic vocalization Restored Monitoring ultrasonic vocalizations P8 Tyzio R , et al. (2014)
Developmental profile NA Not reported NA NA Tyzio R , et al. (2014)
Emotion NA Not reported NA NA Tyzio R , et al. (2014)
Immune response NA Not reported NA NA Tyzio R , et al. (2014)
Learning & memory NA Not reported NA NA Tyzio R , et al. (2014)
Maternal behavior NA Not reported NA NA Tyzio R , et al. (2014)
Molecular profile NA Not reported NA NA Tyzio R , et al. (2014)

M_FMR1_4_CKO_HM_PURKINJEN

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 1 of FMR1 using L7-cre, in Purkinje cells of the cerebellum

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: Not specified

Es cell line: E14
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Mientjes EJ , et al. (2005)
Circadian sleep/wake cycle NA Not reported NA NA Mientjes EJ , et al. (2005)
Motor phenotype NA Not reported NA NA Mientjes EJ , et al. (2005)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Mientjes EJ , et al. (2005)
Neurophysiology NA Not reported NA NA Mientjes EJ , et al. (2005)
Repetitive behavior NA Not reported NA NA Mientjes EJ , et al. (2005)
Seizure NA Not reported NA NA Mientjes EJ , et al. (2005)
Sensory NA Not reported NA NA Mientjes EJ , et al. (2005)
Social behavior NA Not reported NA NA Mientjes EJ , et al. (2005)
Communications NA Not reported NA NA Mientjes EJ , et al. (2005)
Developmental profile Reproductive system development Decreased General observations Unreported Mientjes EJ , et al. (2005)
Developmental profile General characteristics No change General observations Unreported Mientjes EJ , et al. (2005)
Emotion NA Not reported NA NA Mientjes EJ , et al. (2005)
Immune response NA Not reported NA NA Mientjes EJ , et al. (2005)
Learning & memory NA Not reported NA NA Mientjes EJ , et al. (2005)
Maternal behavior NA Not reported NA NA Mientjes EJ , et al. (2005)
Molecular profile Targeted expression Decreased Immunohistochemistry Unreported Mientjes EJ , et al. (2005)

M_FMR1_5_KI_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Knock in of transgene containing ~120 CGG.CCG repeats in the FMR1 gene with a Cre recombinase under the control of the MMTV promoter.

Allele Type: Humanized LOF mutation
Strain of Origin: Not Specified
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Qin M , et al. (2011)
Circadian sleep/wake cycle NA Not reported NA NA Qin M , et al. (2011)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test Unreported Qin M , et al. (2011)
Motor phenotype General locomotor activity Increased Open field test 7-9 weeks Qin M , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Golgi-cox staining 17 weeks Qin M , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Golgi-cox staining 17 weeks Qin M , et al. (2011)
Neurophysiology NA Not reported NA NA Qin M , et al. (2011)
Repetitive behavior NA Not reported NA NA Qin M , et al. (2011)
Seizure NA Not reported NA NA Qin M , et al. (2011)
Sensory NA Not reported NA NA Qin M , et al. (2011)
Social behavior Social memory No change Three-chamber social approach test 8-10 weeks Qin M , et al. (2011)
Social behavior Social approach No change Three-chamber social approach test 8-10 weeks Qin M , et al. (2011)
Communications NA Not reported NA NA Qin M , et al. (2011)
Developmental profile Size/growth No change General observations Unreported Qin M , et al. (2011)
Developmental profile Reproductive system development Decreased Measurement of tissue weight NA Qin M , et al. (2011)
Developmental profile General characteristics No change General observations Unreported Qin M , et al. (2011)
Emotion Anxiety Decreased Elevated zero maze test 10-13 weeks Qin M , et al. (2011)
Emotion Anxiety Decreased Open field test 10-13 weeks Qin M , et al. (2011)
Immune response NA Not reported NA NA Qin M , et al. (2011)
Learning & memory Cued or contextual fear conditioning: passive avoidance Decreased Passive avoidance test 13-16 weeks Qin M , et al. (2011)
Maternal behavior NA Not reported NA NA Qin M , et al. (2011)
Molecular profile Regulation of translation Increased Autoradiographic analysis 17 weeks Qin M , et al. (2011)
Molecular profile Protein expression level evidence Decreased Western blot 3 months Qin M , et al. (2011)
Molecular profile Gene expression Increased Quantitative pcr (qrt-pcr) 3 months Qin M , et al. (2011)

M_FMR1_6_KI_HM_I304N

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Homologous recombination mediated introduction of I304N mutation to FMR1 locus.

Allele Type: Humanized LOF mutation
Strain of Origin: Not Specified
Genetic Background: FVB x C57BL/6J

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Zang JB , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Zang JB , et al. (2009)
Motor phenotype Hyperactivity No change Open field test Unreported Zang JB , et al. (2009)
Motor phenotype General locomotor activity Increased Open field test Unreported Zang JB , et al. (2009)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Zang JB , et al. (2009)
Neurophysiology NA Not reported NA NA Zang JB , et al. (2009)
Repetitive behavior Repetitive digging Increased Marble-burying test Unreported Zang JB , et al. (2009)
Seizure NA Not reported NA NA Zang JB , et al. (2009)
Sensory Sensorimotor gating No change Prepulse inhibition Unreported Zang JB , et al. (2009)
Sensory Pain or nociception Decreased Hot plate test Unreported Zang JB , et al. (2009)
Social behavior NA Not reported NA NA Zang JB , et al. (2009)
Communications NA Not reported NA NA Zang JB , et al. (2009)
Developmental profile Size/growth No change General observations Unreported Zang JB , et al. (2009)
Developmental profile Reproductive system development Increased General observations Unreported Zang JB , et al. (2009)
Developmental profile General characteristics No change General observations Unreported Zang JB , et al. (2009)
Emotion Anxiety Decreased Open field test Unreported Zang JB , et al. (2009)
Emotion Anxiety Decreased Light-dark exploration test Unreported Zang JB , et al. (2009)
Immune response NA Not reported NA NA Zang JB , et al. (2009)
Learning & memory NA Not reported NA NA Zang JB , et al. (2009)
Maternal behavior NA Not reported NA NA Zang JB , et al. (2009)
Molecular profile NA Not reported NA NA Zang JB , et al. (2009)

M_FMR1_7_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin, maintained in a mixed background with FVB and 129P2 corrected for eyesight by the pde6b allele.

Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: FVB.129P2.pde6b+

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA -
Physiological parameters NA Not reported NA NA Antoine MW , et al. (2019)
Physiological parameters NA Not reported NA NA Dansie LE , et al. (2013)
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Physiological parameters NA Not reported NA NA Rogers TD , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA -
Circadian sleep/wake cycle NA Not reported NA NA Antoine MW , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Dansie LE , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Rogers TD , et al. (2013)
Motor phenotype NA Not reported NA NA -
Motor phenotype NA Not reported NA NA Antoine MW , et al. (2019)
Motor phenotype General locomotor activity Increased Elevated plus maze test 4, 8 weeks Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Increased Open field test 4, 8 weeks Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Increased Open field test 10-17 weeks Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Rogers TD , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA -
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Antoine MW , et al. (2019)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dansie LE , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No change Golgi-cox staining 11 weeks Dolan BM , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Golgi-cox staining 11 weeks Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Rogers TD , et al. (2013)
Neurophysiology Neuronal activation No change Whole-cell voltage clamp P17-p23 -
Neurophysiology Synaptic transmission Increased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Synaptic plasticity No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Stimulus-spike relationship: inhibitory Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Network excitability No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Network excitability Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Membrane potential No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Intrinsic membrane properties No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Epsp-spike relationship Decreased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: rate of depolarization No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate Decreased Whole-cell voltage clamp P42-p92 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate No change Whole-cell voltage clamp 2.5 weeks - 3.14 weeks, 2 months Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate No change Cell-attached patch clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: firing rate Increased Whole-cell voltage clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology Action potential property: amplitude No change Whole-cell current clamp P17-p23 Antoine MW , et al. (2019)
Neurophysiology NA Not reported NA NA Dansie LE , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology Neurotransmitter release: catecholamines Decreased In vivo amperometry Unreported Rogers TD , et al. (2013)
Repetitive behavior NA Not reported NA NA -
Repetitive behavior NA Not reported NA NA Antoine MW , et al. (2019)
Repetitive behavior Stereotypy Increased Open field test Unreported Dansie LE , et al. (2013)
Repetitive behavior Repetitive digging Increased Marble-burying test 4, 8 weeks, 2 months Dansie LE , et al. (2013)
Repetitive behavior Stereotypy Increased Open field test 10-17 weeks Dolan BM , et al. (2013)
Repetitive behavior Circling Increased Open field test 10-17 weeks Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Rogers TD , et al. (2013)
Seizure NA Not reported NA NA -
Seizure NA Not reported NA NA Antoine MW , et al. (2019)
Seizure NA Not reported NA NA Dansie LE , et al. (2013)
Seizure Seizures Increased Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Seizure NA Not reported NA NA Rogers TD , et al. (2013)
Sensory NA Not reported NA NA -
Sensory Sensory-evoked response: excitation: tactile stimulus Decreased Whole-cell voltage clamp P42-p92 Antoine MW , et al. (2019)
Sensory Sensory-evoked response: excitation: tactile stimulus Decreased Whole-cell voltage clamp 2.5 weeks - 3.14 weeks, 2 months Antoine MW , et al. (2019)
Sensory NA Not reported NA NA Antoine MW , et al. (2019)
Sensory NA Not reported NA NA Dansie LE , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Rogers TD , et al. (2013)
Social behavior NA Not reported NA NA -
Social behavior NA Not reported NA NA Antoine MW , et al. (2019)
Social behavior NA Not reported NA NA Dansie LE , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Rogers TD , et al. (2013)
Communications NA Not reported NA NA -
Communications NA Not reported NA NA Antoine MW , et al. (2019)
Communications NA Not reported NA NA Dansie LE , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Rogers TD , et al. (2013)
Developmental profile NA Not reported NA NA -
Developmental profile NA Not reported NA NA Antoine MW , et al. (2019)
Developmental profile NA Not reported NA NA Dansie LE , et al. (2013)
Developmental profile Tissue weight Increased General observations 10-17 weeks Dolan BM , et al. (2013)
Developmental profile Size/growth No change General observations 10-17 weeks Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Rogers TD , et al. (2013)
Emotion NA Not reported NA NA -
Emotion NA Not reported NA NA Antoine MW , et al. (2019)
Emotion Anxiety Increased Elevated plus maze test 4, 8 weeks Dansie LE , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Rogers TD , et al. (2013)
Immune response NA Not reported NA NA -
Immune response NA Not reported NA NA Antoine MW , et al. (2019)
Immune response Adaptive immune response: b cells antibody production: igg No change Elisa Unreported Dansie LE , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Rogers TD , et al. (2013)
Learning & memory NA Not reported NA NA -
Learning & memory NA Not reported NA NA Antoine MW , et al. (2019)
Learning & memory NA Not reported NA NA Dansie LE , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Rogers TD , et al. (2013)
Maternal behavior NA Not reported NA NA -
Maternal behavior NA Not reported NA NA Antoine MW , et al. (2019)
Maternal behavior NA Not reported NA NA Dansie LE , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Rogers TD , et al. (2013)
Molecular profile NA Not reported NA NA -
Molecular profile NA Not reported NA NA Antoine MW , et al. (2019)
Molecular profile Protein phosphorylation Increased Elisa Unreported Dansie LE , et al. (2013)
Molecular profile Protein phosphorylation Decreased Elisa Unreported Dansie LE , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Rogers TD , et al. (2013)

M_FMR1_7_KO_HM_FRAX486-H

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 30 mg/kg for 8 hours.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Restored Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486-L-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 8 hours.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486-L-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 5 days and tested 8 hrs after final dose.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486-M-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 8 hours.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No adverse effect Golgi-cox staining 11 weeks Dolan BM , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Golgi-cox staining 11 weeks Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486-M-3

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 5 days and tested 8 hours after final dose.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype Motor coordination and balance No adverse effect Accelerating rotarod test 10-17 weeks Dolan BM , et al. (2013)
Motor phenotype General locomotor activity Restored Open field test 10-17 weeks Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior Stereotypy Restored Open field test 10-17 weeks Dolan BM , et al. (2013)
Repetitive behavior Circling Restored Open field test 10-17 weeks Dolan BM , et al. (2013)
Seizure Seizures Restored Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile Tissue weight Refractory General observations 10-17 weeks Dolan BM , et al. (2013)
Developmental profile Size/growth No adverse effect General observations 10-17 weeks Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_H

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 30 mg/kg for 8 hours.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Restored Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_L

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 8 hours.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_L_D

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 5 days and tested 8 hrs after final dose.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_M

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 8 hours.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No adverse effect Golgi-cox staining 11 weeks Dolan BM , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Golgi-cox staining 11 weeks Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_M-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for one dose and tested 5 days after.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Refractory Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_M_D

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 5 days and tested 8 hours after final dose.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype Motor coordination and balance No adverse effect Accelerating rotarod test 10-17 weeks Dolan BM , et al. (2013)
Motor phenotype General locomotor activity Restored Open field test 10-17 weeks Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior Stereotypy Restored Open field test 10-17 weeks Dolan BM , et al. (2013)
Repetitive behavior Circling Restored Open field test 10-17 weeks Dolan BM , et al. (2013)
Seizure Seizures Restored Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile Tissue weight Refractory General observations 10-17 weeks Dolan BM , et al. (2013)
Developmental profile Size/growth No adverse effect General observations 10-17 weeks Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_FRAX486_M_S

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for one dose and tested 5 days after.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dolan BM , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dolan BM , et al. (2013)
Motor phenotype NA Not reported NA NA Dolan BM , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dolan BM , et al. (2013)
Neurophysiology NA Not reported NA NA Dolan BM , et al. (2013)
Repetitive behavior NA Not reported NA NA Dolan BM , et al. (2013)
Seizure Seizures Refractory Audiogenic seizure test 10-17 weeks Dolan BM , et al. (2013)
Sensory NA Not reported NA NA Dolan BM , et al. (2013)
Social behavior NA Not reported NA NA Dolan BM , et al. (2013)
Communications NA Not reported NA NA Dolan BM , et al. (2013)
Developmental profile NA Not reported NA NA Dolan BM , et al. (2013)
Emotion NA Not reported NA NA Dolan BM , et al. (2013)
Immune response NA Not reported NA NA Dolan BM , et al. (2013)
Learning & memory NA Not reported NA NA Dolan BM , et al. (2013)
Maternal behavior NA Not reported NA NA Dolan BM , et al. (2013)
Molecular profile NA Not reported NA NA Dolan BM , et al. (2013)

M_FMR1_7_KO_HM_MINOCYCLINE

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of minocycline at 30 mg/kg/day in drinking water for 4 or 8 weeks.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Dansie LE , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Restored Elevated plus maze test 4, 8 weeks Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Restored Elevated plus maze test 4, 8 weeks Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Restored Open field test 4, 8 weeks Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Restored Open field test 4, 8 weeks Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Refractory Open field test >2 months Dansie LE , et al. (2013)
Motor phenotype General locomotor activity Restored Open field test >2 months Dansie LE , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Dansie LE , et al. (2013)
Neurophysiology NA Not reported NA NA Dansie LE , et al. (2013)
Repetitive behavior Repetitive digging Refractory Marble-burying test >2 months Dansie LE , et al. (2013)
Repetitive behavior Repetitive digging Restored Marble-burying test >2 months Dansie LE , et al. (2013)
Repetitive behavior Repetitive digging Restored Marble-burying test 4, 8 weeks Dansie LE , et al. (2013)
Repetitive behavior Repetitive digging Restored Marble-burying test 4, 8 weeks; 2 months Dansie LE , et al. (2013)
Seizure Seizures Ameliorated Audiogenic seizure test 4 weeks Dansie LE , et al. (2013)
Sensory NA Not reported NA NA Dansie LE , et al. (2013)
Social behavior NA Not reported NA NA Dansie LE , et al. (2013)
Communications NA Not reported NA NA Dansie LE , et al. (2013)
Developmental profile NA Not reported NA NA Dansie LE , et al. (2013)
Emotion Anxiety Restored Elevated plus maze test 4, 8 weeks Dansie LE , et al. (2013)
Emotion Anxiety Restored Elevated plus maze test 4, 8 weeks Dansie LE , et al. (2013)
Immune response Adaptive immune response: b cells No adverse effect Elisa 10 weeks Dansie LE , et al. (2013)
Learning & memory NA Not reported NA NA Dansie LE , et al. (2013)
Maternal behavior NA Not reported NA NA Dansie LE , et al. (2013)
Molecular profile Protein phosphorylation Restored Elisa >4 weeks Dansie LE , et al. (2013)
Molecular profile Protein phosphorylation Refractory Elisa >4 weeks Dansie LE , et al. (2013)

M_FMR1_8_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

FMR1 KO mice were originally on the C57Bl/6 background but to generate phenotyped in a mixed C57BL/6 129SveJ background form litters.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6.129SVeJ

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Bhattacharya A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Bhattacharya A , et al. (2012)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test Unreported Bhattacharya A , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Golgi-cox staining 3-4 months Bhattacharya A , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Abnormal Golgi-cox staining 3-4 months Bhattacharya A , et al. (2012)
Neurophysiology Synaptic plasticity: ltd Increased Whole-cell patch clamp 3-5 weeks Bhattacharya A , et al. (2012)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Bhattacharya A , et al. (2012)
Seizure NA Not reported NA NA Bhattacharya A , et al. (2012)
Sensory NA Not reported NA NA Bhattacharya A , et al. (2012)
Social behavior Social memory Decreased Three-chamber social approach test Unreported Bhattacharya A , et al. (2012)
Social behavior Social interaction Increased Open field test Unreported Bhattacharya A , et al. (2012)
Communications NA Not reported NA NA Bhattacharya A , et al. (2012)
Developmental profile Size/growth Increased General observations 6 weeks Bhattacharya A , et al. (2012)
Developmental profile Reproductive system development Decreased General observations 3-4 months Bhattacharya A , et al. (2012)
Emotion NA Not reported NA NA Bhattacharya A , et al. (2012)
Immune response NA Not reported NA NA Bhattacharya A , et al. (2012)
Learning & memory Spatial working memory No change Water y-maze test Unreported Bhattacharya A , et al. (2012)
Learning & memory Spatial working memory Decreased Water y-maze test Unreported Bhattacharya A , et al. (2012)
Learning & memory Object recognition memory Decreased Novel object recognition test Unreported Bhattacharya A , et al. (2012)
Maternal behavior NA Not reported NA NA Bhattacharya A , et al. (2012)
Molecular profile Regulation of translation Increased Surface sensing of translation (sunset) Unreported Bhattacharya A , et al. (2012)
Molecular profile Protein phosphorylation Increased Western blot Unreported Bhattacharya A , et al. (2012)
Molecular profile Protein modification process Increased Immunohistochemistry 8-10 weeks Bhattacharya A , et al. (2012)
Molecular profile Protein expression level evidence No change Western blot Unreported Bhattacharya A , et al. (2012)
Molecular profile Protein expression level evidence Increased Western blot Unreported Bhattacharya A , et al. (2012)

M_FMR1_8_KO_HM_S6K1_DM-HM

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

FMR1 KO were crossed with homozygous S6K1 KO mice to produce double knockout, maintained in the mixed background. As they used males, FMR1 was hemizygous.

Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6.129SVeJ

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Bhattacharya A , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Bhattacharya A , et al. (2012)
Motor phenotype Motor coordination and balance Restored Accelerating rotarod test 4-6 months Bhattacharya A , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Golgi-cox staining P90-p100 Bhattacharya A , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Golgi-cox staining P90-p100 Bhattacharya A , et al. (2012)
Neurophysiology Synaptic plasticity: ltd Restored Whole-cell patch clamp P23-p35 Bhattacharya A , et al. (2012)
Neurophysiology Presynaptic function: paired-pulse facilitation No adverse effect Whole-cell patch clamp 3-5 weeks Bhattacharya A , et al. (2012)
Repetitive behavior Stereotypy Refractory Marble-burying test 4-6 months Bhattacharya A , et al. (2012)
Seizure NA Not reported NA NA