FMR1 fragile X mental retardation 1
Model Species
Mus musculusGene Aliases
FMRP; Fmr-1Models / Rescue Models
64 / 24Rescue Model
-Model Summary
Fragile X Syndrome.
External Links
Reports related to FMR1 (41 Reports)
# | Type | Title | Author, Year |
---|---|---|---|
1 | Additional | Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. | Koekkoek SK , et al. (2005) |
2 | Additional | Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model. | Gantois I , et al. (2005) |
3 | Additional | The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. | Mientjes EJ , et al. (2005) |
4 | Additional | Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein. | Selby L , et al. (2007) |
5 | Additional | Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. | Schtt J , et al. (2009) |
6 | Additional | Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. | Shang Y , et al. (2009) |
7 | Additional | Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. | Eadie BD , et al. (2009) |
8 | Additional | Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. | Yuskaitis CJ , et al. (2009) |
9 | Additional | Altered neuroligin expression is involved in social deficits in a mouse model of the fragile X syndrome. | Dahlhaus R and El-Husseini A (2009) |
10 | Additional | A mouse model of the human Fragile X syndrome I304N mutation. | Zang JB , et al. (2009) |
11 | Additional | Dysregulation of mTOR signaling in fragile X syndrome. | Sharma A , et al. (2010) |
12 | Additional | GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism. | Mines MA , et al. (2010) |
13 | Additional | A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis. | Qin M , et al. (2011) |
14 | Additional | Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. | Testa-Silva G , et al. (2011) |
15 | Additional | Reversal of fragile X phenotypes by manipulation of APP/A levels in Fmr1KO mice. | Westmark CJ , et al. (2011) |
16 | Additional | The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. | Olmos-Serrano JL , et al. (2011) |
17 | Additional | Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome. | Rotschafer SE , et al. (2012) |
18 | Additional | Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. | Michalon A , et al. (2012) |
19 | Additional | Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, ... | Costa L , et al. (2012) |
20 | Additional | Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. | Bhattacharya A , et al. (2012) |
21 | Additional | Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder. | Rogers TD , et al. (2013) |
22 | Additional | Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. | Dolan BM , et al. (2013) |
23 | Additional | Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. | Dansie LE , et al. (2013) |
24 | Additional | Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model. | Lim CS , et al. (2014) |
25 | Additional | Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. | Tyzio R , et al. (2014) |
26 | Additional | Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse. | Srensen EM , et al. (2015) |
27 | Additional | Convergence of Hippocampal Pathophysiology in Syngap and Fmr1-/y Mice. | Barnes SA , et al. (2015) |
28 | Additional | Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. | Orefice LL , et al. (2016) |
29 | Additional | Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. | Korb E , et al. (2017) |
30 | Additional | Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor- expression. | Hodges SL , et al. (2017) |
31 | Additional | Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. | Yau SY , et al. (2018) |
32 | Additional | Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors. | Lee Y , et al. (2019) |
33 | Additional | Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models. | Antoine MW , et al. (2019) |
34 | Additional | Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. | Orefice LL , et al. (2019) |
35 | Additional | IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders </title> | () |
36 | Additional | Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations | Xu ZX et al. (2020) |
37 | Additional | ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome | Licznerski P et al. (2020) |
38 | Additional | Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice | Cogram P et al. (2020) |
39 | Additional | Parallel Social Information Processing Circuits Are Differentially Impacted in Autism | Lewis EM et al. (2020) |
40 | Primary | Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. | no authors (1994) |
41 | Primary | Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. | Comery TA , et al. (1997) |
M_FMR1_10_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Purkinje cell specific knock out of FMR1, using L7-cre mice.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: mixed
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Motor phenotype | Spontaneous movement | Increased | Home cage behavior | Unreported | Koekkoek SK , et al. (2005) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Measurement of tissue weight | 2 months | Koekkoek SK , et al. (2005) |
Neurophysiology | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Repetitive behavior | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Seizure | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Sensory | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | Unreported | Koekkoek SK , et al. (2005) |
Social behavior | Social interaction | Increased | Light-dark exploration test | Unreported | Koekkoek SK , et al. (2005) |
Physiological parameters | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Communications | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Developmental profile | Size/growth | Increased | Measurement of tissue weight | 5-7 weeks, 2.5 months; 3.5 months; 5.5 months | Koekkoek SK , et al. (2005) |
Developmental profile | Reproductive system development | No change | General observations | Unreported | Koekkoek SK , et al. (2005) |
Emotion | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Immune response | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Learning & memory | Spatial learning | No change | Morris water maze test | Unreported | Koekkoek SK , et al. (2005) |
Learning & memory | Spatial learning | Decreased | Morris water maze test | Unreported | Koekkoek SK , et al. (2005) |
Learning & memory | Cued or contextual fear conditioning | No change | Fear conditioning test | Unreported | Koekkoek SK , et al. (2005) |
Maternal behavior | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
Molecular profile | NA | Not reported | NA | NA | Koekkoek SK , et al. (2005) |
M_FMR1_11_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
FMR1 KO mice with a mixed FVB and 129P2 background(information not available for pde6b+.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: FVB.129P2
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Motor phenotype | General locomotor activity | Increased | Observation of repetitive behavior | 2 months | Licznerski P et al. (2020) |
Motor phenotype | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synaptic morphology: active zone | Decreased | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synaptic morphology | Decreased | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Mitochondrial number | Decreased | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Mitochondrial matrix morphology | Increased | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Mitochondrial crista morphology | No change | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Decreased | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Abnormal | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Neurophysiology | Mitochondrial membrane potential | Increased | Whole-cell patch clamp | 2 months | Licznerski P et al. (2020) |
Neurophysiology | Mitochondrial ATP synthesis coupled electron transport | Decreased | 9-amino-6-chloro-2-methoxyacridine (ACMA) assay | 2 months | Licznerski P et al. (2020) |
Neurophysiology | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Repetitive behavior | Stereotypy: chewing behavior | Increased | Observation of repetitive behavior | 2 months | Licznerski P et al. (2020) |
Repetitive behavior | Self grooming | Increased | Grooming behavior assessments | 2 months | Licznerski P et al. (2020) |
Repetitive behavior | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Seizure | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Sensory | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Social behavior | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Physiological parameters | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Communications | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Developmental profile | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Emotion | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Immune response | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Learning & memory | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Maternal behavior | NA | Not reported | NA | NA | Sharma A , et al. (2010) |
Molecular profile | Tricarboxylic acid cycle | Increased | Liquid chromatography-mass spectrometry (LC-MS) | 2 months | Licznerski P et al. (2020) |
Molecular profile | Regulation of translation | Increased | Puromycin incorporation assay | 2 months | Licznerski P et al. (2020) |
Molecular profile | Regulation of translation | Increased | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Molecular profile | Protein binding | Decreased | Co-immunoprecipitation | 2 months | Licznerski P et al. (2020) |
Molecular profile | Neuronal activity dependent translation | Decreased | Western blot | 2 months | Licznerski P et al. (2020) |
Molecular profile | Neuronal activity dependent phosphorylation | Decreased | Western blot | 2 months | Licznerski P et al. (2020) |
Molecular profile | Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | Increased | Native non-denaturing polyacrylamide gel electrophoresis | 2 months | Licznerski P et al. (2020) |
Molecular profile | Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | Increased | Western blot | 2 months | Licznerski P et al. (2020) |
Molecular profile | Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) | Increased | Western blot | 2 months | Licznerski P et al. (2020) |
Molecular profile | Mitochondrial proton-transporting ATP synthase complex assembly | No change | Native non-denaturing polyacrylamide gel electrophoresis | 2 months | Licznerski P et al. (2020) |
Molecular profile | Glycolysis | Increased | Liquid chromatography-mass spectrometry (LC-MS) | 2 months | Licznerski P et al. (2020) |
Molecular profile | Regulation of gene expression | Increased | Western blot | 4-6 weeks | Sharma A , et al. (2010) |
Molecular profile | Protein phosphorylation | No change | Western blot | 4-6 weeks | Sharma A , et al. (2010) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 4-6 weeks, 6-8 months | Sharma A , et al. (2010) |
Molecular profile | Protein expression level evidence | No change | Western blot | 4-6 weeks; 6-8 months | Sharma A , et al. (2010) |
Molecular profile | Enzyme activity | No change | Western blot | 4-6 weeks | Sharma A , et al. (2010) |
Molecular profile | Enzyme activity | Increased | Western blot | 4-6 weeks | Sharma A , et al. (2010) |
Molecular profile | Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) | Increased | - | - | et al. () |
M_FMR1_11_KO_HM_CYCLOSPORIN-A
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Brain slices from fvb.129p2 mice that have a neomycin resistance cassette replacing exon 5 were treated with cyclosporina or vehicle for 2.5 hours at a final concentraion between 0.2 and 0.5 um, before electron microscopy.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: FVB.129P2
Es cell line: NA
Model Source: Jackson Laboratories
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Molecular profile | Regulation of translation | Ameliorated | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Molecular profile | Neuronal activity dependent translation | Restored | Western blot | 2 months | Licznerski P et al. (2020) |
Molecular profile | Neuronal activity dependent phosphorylation | Restored | Western blot | 2 months | Licznerski P et al. (2020) |
M_FMR1_11_KO_HM_DEXPRAMIPEXOLE-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Dexpramipexole was added to the electrophysiology bath at a final concentration 10 mm with ex vivo cortical slices from fvb.129p2 mice that have a neomycin resistance cassette replacing exon 5.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: FVB.129P2
Es cell line: NA
Model Source: Jackson Laboratories
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Restored | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Electron microscopy | 2 months | Licznerski P et al. (2020) |
Neurophysiology | Mitochondrial membrane potential | Ameliorated | Whole-cell patch clamp | 2 months | Licznerski P et al. (2020) |
Neurophysiology | Mitochondrial ATP synthesis coupled electron transport | Restored | 9-amino-6-chloro-2-methoxyacridine (ACMA) assay | 2 months | Licznerski P et al. (2020) |
Molecular profile | Regulation of translation | Restored | Puromycin incorporation assay | 2 months | Licznerski P et al. (2020) |
M_FMR1_11_KO_HM_DEXPRAMIPEXOLE-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
2-month old fmr1^-/y mutant fvb.129p2 mice that have a neomycin resistance cassette replacing exon 5 were injected with dexpramipexole including 3 intraperitoneal injections of 10 mg/kg dex or saline over 40 h prior to behavioral testing.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: FVB.129P2
Es cell line: NA
Model Source: Jackson Laboratories
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | General locomotor activity | Restored | Observation of repetitive behavior | 2 months | Licznerski P et al. (2020) |
Repetitive behavior | Stereotypy: chewing behavior | Restored | Observation of repetitive behavior | 2 months | Licznerski P et al. (2020) |
Repetitive behavior | Self grooming | Restored | Grooming behavior assessments | 2 months | Licznerski P et al. (2020) |
M_FMR1_12_KO_HM
Model Type: Genetic
Model Genotype: Homozygous; hemizygous
Mutation:
FMR1 knockout mice on the FVB/NJ background. (Construct details not available).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: FVB/NJ
Es cell line: Not Specified
Model Source: Lugo Lab, Baylor University (PMID 28915148)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Communications | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Immune response | Cytokine levels: pro-inflammatory | No change | Quantitative pcr (qrt-pcr) | Adult | Hodges SL , et al. (2017) |
Immune response | Cytokine levels: pro-inflammatory | Decreased | Quantitative pcr (qrt-pcr) | Adult | Hodges SL , et al. (2017) |
Immune response | Cytokine levels: chemokine | No change | Quantitative pcr (qrt-pcr) | Adult | Hodges SL , et al. (2017) |
Immune response | Cytokine levels: anti-inflammatory | No change | Quantitative pcr (qrt-pcr) | Adult | Hodges SL , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Hodges SL , et al. (2017) |
M_FMR1_13_KD
Model Type: Genetic
Model Genotype: Wildtype
Mutation:
Seven-week-old wildtype C57BL/6 male mice were injected with Fmr1-siRNA (1358762, NM_008031.2), bilaterally in the dorsal striatum using a stereotaxic apparatus, resulting in a reduction of Fmr1 transcript levels to 0.4 fold compared with control siRNA injected mice.
Allele Type: Knockdown
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
Es cell line: NA
Model Source: Daehan BioLink (Eumsung, Chungbuk, Republic of Korea)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Motor phenotype | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Repetitive behavior | Self grooming: perseveration | No change | Grooming behavior assessments | Adult | Lee Y , et al. (2019) |
Repetitive behavior | Repetitive digging | No change | Home cage behavior | Adult | Lee Y , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Sensory | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Social behavior | Social memory | Decreased | U-field assay | Adult | Lee Y , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Communications | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Emotion | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Learning & memory | Object recognition memory | Decreased | Object preference test | Adult | Lee Y , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | Adult | Lee Y , et al. (2019) |
M_FMR1_14_KO_HE
Model Type: Genetic
Model Genotype: Homozygous/Hemizygous
Mutation:
FMR1 mutant gene was generated by construction a targeting vector using homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo). FMR1 homozygous knockout mice (FMR1^tm1Cgr) were bred with NeuroD1 bacTRAP (ND1-BT) heterozygous mice (PMID 28823556) to generate FMR1 and ND-BT1 dual heterozygous female mice that were bred with FMR1-/y male mice to generate FMR1 null and ND1-BT heterozygous (FMR1-/-;ND1-BT /-) that were used for experimentations; M_FMR1_1_KO_HM
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J*129/SvEv*CD1
Es cell line: -
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Sensory | Startle response: acoustic stimulus | No change | Acoustic startle reflex test | 6-8 weeks | Orefice LL , et al. (2019) |
Sensory | Sensorimotor gating: tactile cue | Increased | Response to air puff | 6-8 weeks | Orefice LL , et al. (2019) |
Sensory | Sensorimotor gating: tactile cue | Increased | Prepulse inhibition | 6-8 weeks | Orefice LL , et al. (2019) |
M_FMR1_14_KO_HE_ISOGUVACINE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous/Hemizygous
Mutation:
Isoguvacine is a potent and selective agonist for the GABAAR that does not cross the blood brain barrier and so is a peripherally restricted GABAAR agonist. Isoguvacine, 2 mg/kg, i.p., was administered beginning at a young age (P1-P42) to test if it ameliorated tactile hypersensitivity in ASD models with fewer adverse effects than brain-penetrating benzodiazepines such as midazolam, including sedation and cognitive impairment, which are attributed to a CNS site of drug action.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J*129/SvEv*CD1
Es cell line: -
Model Source: Not specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Sensory | Startle response: acoustic stimulus | No adverse effect | Acoustic startle reflex test | 6 weeks | Orefice LL , et al. (2019) |
Sensory | Sensorimotor gating: tactile cue | Restored | Response to air puff | 6 weeks | Orefice LL , et al. (2019) |
Sensory | Sensorimotor gating: tactile cue | Restored | Prepulse inhibition | 6 weeks | Orefice LL , et al. (2019) |
M_FMR1_15_KO_HM
Model Type: Genetic LOF
Model Genotype: Homozygous
Mutation:
Fmr1 ko mice with a deletion of the promotor and the first exon.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Hyperactivity | Increased | Open field test | 2 months | Cogram P et al. (2020) |
Repetitive behavior | Repetitive digging | Decreased | Marble-burying test | 2 months | Cogram P et al. (2020) |
Social behavior | Nest building behavior | Increased | Nest building assay | 2 months | Cogram P et al. (2020) |
Emotion | Exploratory activity: Habituation | Decreased | Open field test | 2 months | Cogram P et al. (2020) |
Learning & memory | Cued or contextual fear conditioning: Memory of context | Decreased | Fear conditioning test | 2 months | Cogram P et al. (2020) |
M_FMR1_15_KO_HM_BRYOSTATIN1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Fmr1 ko mice with a deletion of the promotor and the first exon received chronic treatment of bryostatin1 ( (0.1 mg/ml) ) for 13 weeks.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Hyperactivity | Ameliorated | Open field test | 2 months | Cogram P et al. (2020) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 2 months | Cogram P et al. (2020) |
Social behavior | Nest building behavior | Restored | Nest building assay | 2 months | Cogram P et al. (2020) |
Emotion | Exploratory activity: Habituation | Restored | Open field test | 2 months | Cogram P et al. (2020) |
Learning & memory | Cued or contextual fear conditioning: Memory of context | Restored | Fear conditioning test | 2 months | Cogram P et al. (2020) |
M_FMR1_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous; hemizygous
Mutation:
FMR1 mutant gene was generated by construction a targeting vector using homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo). FMR1 homozygous knockout mice (FMR1^tm1Cgr) were bred with NeuroD1 bacTRAP (ND1-BT) heterozygous mice (PMID 28823556) to generate FMR1 and ND-BT1 dual heterozygous female mice that were bred with FMR1-/y male mice to generate FMR1 null and ND1-BT heterozygous (FMR1-/-;ND1-BT+/-) that were used for experimentations.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J
Es cell line: E14
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | () |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Motor phenotype | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Motor phenotype | General locomotor activity | No change | Conditioned place preference test | 3 - 7 weeks | Lewis EM et al. (2020) |
Motor phenotype | NA | Not reported | NA | NA | () |
Motor phenotype | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 5 weeks | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 4-8 weeks | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Novel object recognition test | 4-8 weeks | Korb E , et al. (2017) |
Motor phenotype | Hyperactivity | Increased | Three-chamber social approach test | 7-10 weeks | Srensen EM , et al. (2015) |
Motor phenotype | Hyperactivity | Increased | Open field test | 7-10 weeks | Srensen EM , et al. (2015) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Motor phenotype | General locomotor activity | Increased | Open field test | 2-5 months | Michalon A , et al. (2012) |
Motor phenotype | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Motor phenotype | General locomotor activity | No change | Open field test | Unreported | Westmark CJ , et al. (2011) |
Motor phenotype | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Motor phenotype | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Motor phenotype | Swimming ability | Increased | Swim test | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Motor phenotype | General locomotor activity | Increased | Open field test | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Motor phenotype | General locomotor activity | No change | Open field test | Unreported | Eadie BD , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Immunohistochemistry | 8 weeks | Comery TA , et al. (1997) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology of the basal ganglia: Ventral striatum or nucleus accumbens | Abnormal | Retrograde labeling assay | 3 - 7 weeks | Lewis EM et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hypothalamic morphology | Decreased | Immunohistochemistry | 3 - 7 weeks | Lewis EM et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial number | No change | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial number | Increased | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial morphology | No change | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial morphology | Increased | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | () |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Decreased | Western blot | Adult | Yau SY , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Sholl analysis | Adult | Yau SY , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Decreased | Sholl analysis | Adult | Yau SY , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Immunohistochemistry | 4-8 weeks | Korb E , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Golgi-cox staining | Unreported | Michalon A , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Immunohistochemistry | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Decreased | Immunohistochemistry | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | No change | Immunohistochemistry | Unreported | Eadie BD , et al. (2009) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain development | Decreased | Immunohistochemistry | Unreported | Eadie BD , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | Decreased | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Synaptic plasticity: ltd | Increased | Field potential recordings | 3-4 weeks | Michalon A , et al. (2012) |
Neurophysiology | Synaptic plasticity | Increased | Field potential recordings | 2 months | Michalon A , et al. (2012) |
Neurophysiology | Synaptic plasticity | Increased | Field potential recordings | 3 months | Westmark CJ , et al. (2011) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Paired-pulse ratio | Unreported | Westmark CJ , et al. (2011) |
Neurophysiology | Synaptic transmission | No change | Whole-cell patch clamp | 4-5 weeks | Testa-Silva G , et al. (2011) |
Neurophysiology | Synaptic transmission | Increased | Whole-cell patch clamp | Unreported | Testa-Silva G , et al. (2011) |
Neurophysiology | Synaptic plasticity: ltd | No change | Whole-cell patch clamp | 4-5 weeks | Testa-Silva G , et al. (2011) |
Neurophysiology | Synaptic plasticity: ltd | Decreased | Whole-cell patch clamp | Unreported | Testa-Silva G , et al. (2011) |
Neurophysiology | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Neurophysiology | Neuronal activation | Increased | Immunohistochemistry | Adult, 2-5 months, 9-12 months | () |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Decreased | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Epsp-spike relationship | No change | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Epsp-spike relationship | Decreased | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Neurophysiology | Neurotransmitter release: catecholamines | Increased | High-performance liquid chromatography (hplc) | 7-10 weeks | Srensen EM , et al. (2015) |
Neurophysiology | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | Neurotransmitter release: catecholamines | No change | In vivo amperometry | Unreported | Rogers TD , et al. (2013) |
Neurophysiology | Neurotransmitter release: catecholamines | Decreased | In vivo amperometry | Unreported | Rogers TD , et al. (2013) |
Neurophysiology | Neurotransmitter release: catecholamines | Decreased | In vivo amperometry | Unreported | Rogers TD , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Neurophysiology | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Neurophysiology | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Repetitive behavior | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Repetitive behavior | NA | Not reported | NA | NA | () |
Repetitive behavior | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Repetitive behavior | Repetitive digging | Increased | Marble-burying test | 4.3 weeks, 6-8 weeks | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 4-6 weeks | Srensen EM , et al. (2015) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Repetitive behavior | Repetitive digging | Decreased | Marble-burying test | 8-10 weeks | Westmark CJ , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Repetitive behavior | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Seizure | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Seizure | NA | Not reported | NA | NA | () |
Seizure | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Seizure | Seizures | Increased | Acoustic startle reflex test | Unreported | Michalon A , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Seizure | Seizures | Increased | Audiogenic seizure test | P21 | Westmark CJ , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Seizure | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Seizure | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Sensory | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Sensory | NA | Not reported | NA | NA | () |
Sensory | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Sensory | Startle response: acoustic stimulus | Increased | Acoustic startle reflex test | Unreported | Michalon A , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Sensory | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Sensory | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Sensory | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Sensory | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Social behavior | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Social behavior | Peer-to-peer social attachment | Decreased | Social conditioned place preference test | 3 - 7 weeks | Lewis EM et al. (2020) |
Social behavior | Filial social attachment | No change | Alloparent conditioned place preference test | 3 - 7 weeks | Lewis EM et al. (2020) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | Adult | () |
Social behavior | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Social behavior | Social approach | Increased | Three-chamber social approach test | 4.3 weeks, 6-8 weeks | Korb E , et al. (2017) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 7-10 weeks | Srensen EM , et al. (2015) |
Social behavior | Social approach | No change | Three-chamber social approach test | 7-10 weeks | Srensen EM , et al. (2015) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Social behavior | Mating behavior | No change | Reciprocal social interaction test | Unreported | Rotschafer SE , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Social behavior | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | No change | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | No change | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | No change | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | Increased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | Increased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | Decreased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social approach | No change | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social approach | No change | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social approach | Increased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Self grooming: social context | No change | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 2-6 months | Dahlhaus R and El-Husseini A (2009) |
Social behavior | Social interaction | Decreased | Resident-intruder test | 2-6 months | Dahlhaus R and El-Husseini A (2009) |
Social behavior | Aggression | No change | Resident-intruder test | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Social behavior | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Physiological parameters | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Physiological parameters | NA | Not reported | NA | NA | () |
Physiological parameters | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Physiological parameters | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Physiological parameters | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Physiological parameters | Hormone levels | No change | Elisa | Unreported | Eadie BD , et al. (2009) |
Physiological parameters | Hormone levels | Decreased | Elisa | Unreported | Eadie BD , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Communications | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Communications | NA | Not reported | NA | NA | () |
Communications | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Communications | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Communications | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Communications | Ultrasonic vocalization | No change | Monitoring ultrasonic vocalizations | Unreported | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Communications | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Communications | Ultrasonic vocalization | Decreased | Monitoring ultrasonic vocalizations | Unreported | Rotschafer SE , et al. (2012) |
Communications | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Communications | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Communications | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Communications | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Communications | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Communications | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Communications | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Developmental profile | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Developmental profile | NA | Not reported | NA | NA | () |
Developmental profile | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Developmental profile | Tissue weight | Increased | General observations | 5-17 weeks | Michalon A , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Developmental profile | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Developmental profile | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Developmental profile | Size/growth | Increased | General observations | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Developmental profile | Mortality/lethality | No change | General observations | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Developmental profile | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Developmental profile | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Developmental profile | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Emotion | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Emotion | NA | Not reported | NA | NA | () |
Emotion | Exploratory activity: habituation | No change | Object-place recognition test | Adult | Yau SY , et al. (2018) |
Emotion | Depression | No change | Forced swim test | Adult | Yau SY , et al. (2018) |
Emotion | Depression | No change | Tail suspension test | Adult | Yau SY , et al. (2018) |
Emotion | Anxiety | No change | Open field test | Adult | Yau SY , et al. (2018) |
Emotion | Anxiety | No change | Open field test | 6-8 weeks | Korb E , et al. (2017) |
Emotion | Anxiety | Increased | Open field test | 5 weeks | Korb E , et al. (2017) |
Emotion | Anxiety | Increased | Open field test | 7-10 weeks | Srensen EM , et al. (2015) |
Emotion | Anxiety | Decreased | Elevated plus maze test | P29 | Lim CS , et al. (2014) |
Emotion | Anxiety | Decreased | Light-dark exploration test | P29 | Lim CS , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Emotion | Anxiety | Decreased | Open field test | Unreported | Westmark CJ , et al. (2011) |
Emotion | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Emotion | Anxiety | Increased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Emotion | Anxiety | Decreased | Three-chamber social approach test | 3 months | Mines MA , et al. (2010) |
Emotion | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Emotion | Anxiety | Decreased | Elevated plus maze test | 2-4 months | Eadie BD , et al. (2009) |
Emotion | Anxiety | Decreased | Open field test | 2-4 months | Eadie BD , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Immune response | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Immune response | NA | Not reported | NA | NA | () |
Immune response | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Immune response | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Immune response | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Learning & memory | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Learning & memory | Reward reinforced choice behavior: cocaine | No change | Cocaine conditioned place preference test | 3 - 7 weeks | Lewis EM et al. (2020) |
Learning & memory | NA | Not reported | NA | NA | () |
Learning & memory | Spatial reference memory | Decreased | Object-place recognition test | Adult | Yau SY , et al. (2018) |
Learning & memory | Procedural learning | No change | Novel object recognition test | Adult | Yau SY , et al. (2018) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | Adult | Yau SY , et al. (2018) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 4-8 weeks | Korb E , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Learning & memory | Reward reinforced choice behavior | Decreased | Y-maze test | P29 | Lim CS , et al. (2014) |
Learning & memory | Eye blink conditioning | Decreased | Eyeblink conditioning | Unreported | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Decreased | Passive avoidance test | Unreported | Michalon A , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Learning & memory | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Learning & memory | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Learning & memory | Spatial learning | No change | Morris water maze test | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Learning & memory | Object recognition memory | No change | Novel object recognition test | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Learning & memory | Spatial reference memory | No change | Morris water maze test | 2-4 months | Eadie BD , et al. (2009) |
Learning & memory | Spatial reference memory | No change | Plus-shaped water maze test | 2-4 months | Eadie BD , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Maternal behavior | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Maternal behavior | NA | Not reported | NA | NA | () |
Maternal behavior | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Maternal behavior | NA | Not reported | NA | NA | Dahlhaus R and El-Husseini A (2009) |
Maternal behavior | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Gantois I , et al. (2005) |
Molecular profile | NA | Not reported | NA | NA | Comery TA , et al. (1997) |
Molecular profile | Transcriptome diversity | Decreased | Flow cytometric analysis | 3 - 7 weeks | Lewis EM et al. (2020) |
Molecular profile | Differential gene expression | Abnormal | RNA sequencing | 3 - 7 weeks | Lewis EM et al. (2020) |
Molecular profile | NA | Not reported | NA | NA | () |
Molecular profile | Protein phosphorylation | Increased | Western blot | Adult | Yau SY , et al. (2018) |
Molecular profile | Protein localization: synapse | Decreased | Western blot | Adult | Yau SY , et al. (2018) |
Molecular profile | Regulation of gene expression | Abnormal | Rna sequencing | 2.1 weeks | Korb E , et al. (2017) |
Molecular profile | Protein-dna complex assembly | Increased | Quantitative pcr (qrt-pcr) | 2.1 weeks | Korb E , et al. (2017) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 2.1 weeks | Korb E , et al. (2017) |
Molecular profile | Protein expression level evidence | Increased | Western blot | 2.1 weeks | Korb E , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | Not specified | Korb E , et al. (2017) |
Molecular profile | Chromatin modification: histone modification: open chromatin | Increased | Chromatin immunoprecipitation sequencing (chip-seq) | 2.1 weeks | Korb E , et al. (2017) |
Molecular profile | Chromatin modification | No change | Chromatin immunoprecipitation sequencing (chip-seq) | 2.1 weeks | Korb E , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Srensen EM , et al. (2015) |
Molecular profile | Signaling | Decreased | Western blot | P14, p29 | Lim CS , et al. (2014) |
Molecular profile | Protein modification process | Increased | Western blot | P14, p29 | Lim CS , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Molecular profile | Signaling | Decreased | Western blot | Unreported | Michalon A , et al. (2012) |
Molecular profile | Regulation of translation | Increased | Metabolic labeling of proteins | Unreported | Michalon A , et al. (2012) |
Molecular profile | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Molecular profile | Protein expression level evidence | Increased | Western blot | 1 month | Westmark CJ , et al. (2011) |
Molecular profile | NA | Not reported | NA | NA | Testa-Silva G , et al. (2011) |
Molecular profile | NA | Not reported | NA | NA | Mines MA , et al. (2010) |
Molecular profile | Protein expression level evidence | No change | Immunohistochemistry | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Molecular profile | Protein expression level evidence | Decreased | Immunohistochemistry | 2.5 - 6 months | Dahlhaus R and El-Husseini A (2009) |
Molecular profile | NA | Not reported | NA | NA | Eadie BD , et al. (2009) |
Molecular profile | NA | Not reported | NA | NA | Schtt J , et al. (2009) |
Molecular profile | Transcriptome diversity | No change | Gene expression microarray | Unreported | Gantois I , et al. (2005) |
Molecular profile | Transcriptome diversity | No change | Quantitative pcr (qrt-pcr) | Unreported | Gantois I , et al. (2005) |
Molecular profile | Regulation of translation | No change | Quantitative pcr (qrt-pcr) | Unreported | Gantois I , et al. (2005) |
Molecular profile | Regulation of translation | No change | Semi-quantitative pcr (qrt-pcr) | Unreported | Gantois I , et al. (2005) |
Molecular profile | Protein expression: in situ protein expression | No change | Immunohistochemistry | 4 months | Gantois I , et al. (2005) |
Molecular profile | Protein expression: in situ protein expression | No change | Immunohistochemistry | 4 months | Gantois I , et al. (2005) |
Molecular profile | Protein expression level evidence | Decreased | Immunohistochemistry | 10 weeks | Gantois I , et al. (2005) |
Molecular profile | Gene expression | Abnormal | Semi-quantitative pcr (qrt-pcr) | 10-11 weeks | Gantois I , et al. (2005) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 9-13 weeks | Gantois I , et al. (2005) |
Molecular profile | Gene expression | Decreased | Differential display analysis of hippocampus | 9-13 weeks | Gantois I , et al. (2005) |
M_FMR1_1_KO_HM_5HT2BAG+D1AG+PI3KINHIBITOR
Model Type: Pharmaceutical intervention
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. A cocktail of 5HT and Dopamine receptor agonist and antagonist was coadministered. The 5HT 2B-R agonist BW723C86 (0.05mg/kg) and 5HT 2A-R-Antagonist MDL11939 (0.01mg/kg)The D1- R agonist SKF81297 (0.05mg/kg) and D2-R antagonist Sulpiride (0.25mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | Reward reinforced choice behavior | Decreased | Y-maze test | P29 | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_5HT2BAG-CA1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. The 5HT 2B-R agonist BW723C86 (5mg/kg) and 5HT 2A-R-Antagonist MDL11939 (1mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | Rectification of ion channels | Ameliorated | Whole-cell patch clamp | P14, p29 | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | Anxiety | Side effect | Elevated plus maze test | P29 | Lim CS , et al. (2014) |
Emotion | Anxiety | Side effect | Light-dark exploration test | P29 | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | Reward reinforced choice behavior | Ameliorated | Y-maze test | P29 | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Ameliorated | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | Protein modification process | Ameliorated | Western blot | P14, p29 | Lim CS , et al. (2014) |
Molecular profile | Protein modification process | Ameliorated | Western blot | P14, p29 | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_5HT2BAG-L2-3
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the barrel cortex. s to achieve expression in one third of the CA1 pyramidal neurons. The 5HT 2B-R agonist BW723C86 (5mg/kg) and 5HT 2A-R-Antagonist MDL11939 (1mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection. The compounds were dissolved in saline and saline was given to vehicle controls.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | Rectification of ion channels | Ameliorated | Whole-cell patch clamp | P14, p29 | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_5HT2BAG_D1AG
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. A cocktail of 5HT and Dopamine receptor agonist and antagonist was coadministered. The 5HT 2B-R agonist BW723C86 (0.05mg/kg) and 5HT 2A-R-Antagonist MDL11939 (0.01mg/kg)The D1- R agonist SKF81297 (0.05mg/kg) and D2-R antagonist Sulpiride (0.25mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | Rectification of ion channels | Ameliorated | Whole-cell patch clamp | Unreported | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | P29 | Lim CS , et al. (2014) |
Emotion | Anxiety | No adverse effect | Light-dark exploration test | P29 | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | Reward reinforced choice behavior | Restored | Y-maze test | P29 | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Restored | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | Signaling | Ameliorated | Western blot | P14, p29 | Lim CS , et al. (2014) |
Molecular profile | Protein modification process | Restored | Western blot | P14 or 29 | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_APP
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Homologous recombination mediated deletion of exon 5 of FMR1 gene crossed with App heterozygote knockouts.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Motor phenotype | General locomotor activity | Restored | Open field test | NA | Westmark CJ , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Neurophysiology | Synaptic plasticity | Restored | Field potential recordings | 3 months | Westmark CJ , et al. (2011) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No adverse effect | Paired-pulse ratio | Unreported | Westmark CJ , et al. (2011) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 8-10 weeks | Westmark CJ , et al. (2011) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | P21 | Westmark CJ , et al. (2011) |
Sensory | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Social behavior | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Communications | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Developmental profile | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Emotion | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Learning & memory | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Westmark CJ , et al. (2011) |
Molecular profile | Protein expression level evidence | Restored | Western blot | 1 month | Westmark CJ , et al. (2011) |
M_FMR1_1_KO_HM_CTEP_A
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination mediated targeting against Exon 5 of FMR1 followed by acute treatment of CTEP of 2 mg/kg per os (s.c.) 24 hr prior.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Motor phenotype | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Neurophysiology | Synaptic plasticity: ltd | Restored | Field potential recordings | P25-p30 | Michalon A , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Seizure | Seizures | Restored | Acoustic startle reflex test | P18-p22 | Michalon A , et al. (2012) |
Seizure | Seizures | Ameliorated | Acoustic startle reflex test | 1-2 months | Michalon A , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Molecular profile | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
M_FMR1_1_KO_HM_CTEP_C
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination mediated targeting against Exon 5 of FMR1 followed by chronic treatment of CTEP.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Motor phenotype | Motor coordination and balance | No adverse effect | Accelerating rotarod test | Unreported | Michalon A , et al. (2012) |
Motor phenotype | Grip strength | Refractory | Grip strength test | 9 weeks | Michalon A , et al. (2012) |
Motor phenotype | General locomotor activity | Restored | Open field test | 2-5 months | Michalon A , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Golgi-cox staining | P58-p63 | Michalon A , et al. (2012) |
Neurophysiology | Synaptic plasticity | Restored | Field potential recordings | P58-p65 | Michalon A , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Sensory | Startle response: acoustic stimulus | Restored | Acoustic startle reflex test | P58-p63 | Michalon A , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Developmental profile | Tissue weight | Ameliorated | General observations | 5-17 weeks | Michalon A , et al. (2012) |
Developmental profile | Size/growth | Side effect | General observations | Unreported | Michalon A , et al. (2012) |
Developmental profile | Developmental trajectory | Restored | Irwin battery of neurological tests | 9 weeks | Michalon A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Restored | Passive avoidance test | P58-p63 | Michalon A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Molecular profile | Signaling | Restored | Western blot | P58-p63 | Michalon A , et al. (2012) |
M_FMR1_1_KO_HM_CX
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or 5 mg/kg of CX-4945 dissolved in DMSO, and diluted 1:10 into cyclodextrin. CX-4945 is an inhibitor of the kinase that activates Brd4, casein kinase 2 (CK2).
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Ameliorated | Open field test | 4-8 weeks | Korb E , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | 4-8 weeks | Korb E , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Communications | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Emotion | Anxiety | Refractory | Open field test | 5 weeks | Korb E , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Molecular profile | Gene expression | Refractory | Quantitative pcr (qrt-pcr) | 4-8 weeks | Korb E , et al. (2017) |
M_FMR1_1_KO_HM_D1AGONIST-CA1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. For behavioral tests 10-12 injections of 6 ul high titer viral solutions were delivered along the entire hippocampus of both sides to achieve expression in one third of the CA1 pyramidal neurons. The D1- R agonist SKF81297 (5mg/kg) and D2-R antagonist Sulpiride (25mg/kg) were administered by four i.p. injections spaced by 4-6 h. The administration started 4-10 h before the viral injection and 16-20 h before behavioral tests. The compounds were dissolved in saline and saline was given to vehicle controls.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | Rectification of ion channels | Ameliorated | Whole-cell patch clamp | P14, p29 | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | Reward reinforced choice behavior | Ameliorated | Y-maze test | P29 | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Ameliorated | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | Protein modification process | Ameliorated | Western blot | P14, p29 | Lim CS , et al. (2014) |
Molecular profile | Protein modification process | Ameliorated | Western blot | P14, p29 | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_D1AGONIST-L2-3
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1-GFP viral contruct was injected through a glass pipette, stereotaxically into the barrel cortex. T The D1- R agonist SKF81297 (5mg/kg) and D2-R antagonist Sulpiride (25mg/kg) were administered by four i.p. injections spaced by 4-6 h. To determine the role of the PI3K/PKB signaling pathway a PI3K inhibitor LY294002 was administered at a dose of 5mg/kg. The administration started 4-10 h before the viral injection. The compounds were dissolved in saline and saline was given to vehicle controls.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | Rectification of ion channels | Ameliorated | Whole-cell patch clamp | P14, p29 | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_GLUA1CT-5HT2BAG+D1AG
Model Type: Pharmaceutical intervention
Model Genotype: Homozygous
Mutation:
Postnatal day 14 to 29 d old mice were anesthetized by an i.p. injection of 10mg/kg ketamine and 2mg/kg xylazine. A GluA1ct-GFP viral contruct was injected through a glass pipette, stereotaxically into the hippocampal CA1 region. The GluA!ct is a GFP taged cytiplasmic domain of GluA1 receptor subunit that acts as a dominant negative construct selectively blocking synaptic trafficking of endogenous or viral GluA1 contianing AMPA-rs.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Communications | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Learning & memory | Reward reinforced choice behavior | Decreased | Y-maze test | P29 | Lim CS , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | P29 | Lim CS , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Lim CS , et al. (2014) |
M_FMR1_1_KO_HM_IL17A-S1DZ
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Recombinant IL17a protein (50 ng per side in 1 microliter at a rate of 180 nl/min, 7956-ML/CF, R&D) was administered directly and bilaterally into the primary somatosensory cortex dysgranular zone in adult male Fmr1 mutant four hours before testing.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J
Es cell line: E14
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | () |
Motor phenotype | NA | Not reported | NA | NA | () |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | () |
Neurophysiology | NA | Not reported | NA | NA | () |
Repetitive behavior | NA | Not reported | NA | NA | () |
Seizure | NA | Not reported | NA | NA | () |
Sensory | NA | Not reported | NA | NA | () |
Social behavior | Social approach | Restored | Three-chamber social approach test | Adult | () |
Physiological parameters | NA | Not reported | NA | NA | () |
Communications | NA | Not reported | NA | NA | () |
Developmental profile | NA | Not reported | NA | NA | () |
Emotion | NA | Not reported | NA | NA | () |
Immune response | NA | Not reported | NA | NA | () |
Learning & memory | NA | Not reported | NA | NA | () |
Maternal behavior | NA | Not reported | NA | NA | () |
Molecular profile | NA | Not reported | NA | NA | () |
M_FMR1_1_KO_HM_JQ1-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or JQ1 at 5 mg/kg, dissolved in DMSO, and diluted 1:10 into cyclodextrin.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Ameliorated | Open field test | 4-8 weeks | Korb E , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | Ameliorated | Marble-burying test | 4-8 weeks | Korb E , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Communications | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Emotion | Anxiety | Refractory | Open field test | 5 weeks | Korb E , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Molecular profile | Gene expression | Ameliorated | Quantitative pcr (qrt-pcr) | 4-8 weeks | Korb E , et al. (2017) |
M_FMR1_1_KO_HM_JQ1-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or JQ1 at 25 mg/kg dissolved in DMSO, and diluted 1:10 into cyclodextrin.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Restored | Open field test | 4-8 weeks | Korb E , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 4-8 weeks | Korb E , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Communications | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Developmental profile | Integumentary system development | No adverse effect | Immunohistochemistry | Not specified | Korb E , et al. (2017) |
Developmental profile | Digestive system development | No adverse effect | Immunohistochemistry | Not specified | Korb E , et al. (2017) |
Emotion | Exploratory activity | No adverse effect | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Emotion | Anxiety | No adverse effect | Open field test | 4-8 weeks | Korb E , et al. (2017) |
Immune response | Adaptive immune response: t cells | No adverse effect | Flow cytometric analysis | Not specified | Korb E , et al. (2017) |
Learning & memory | Object recognition memory | Ameliorated | Novel object recognition test | 4-8 weeks | Korb E , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Korb E , et al. (2017) |
M_FMR1_1_KO_HM_JQ1-3
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone (controls) or JQ1 at 50 mg/kg dissolved in DMSO, and diluted 1:10 into cyclodextrin.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No adverse effect | Three-chamber social approach test | 4.3 weeks | Korb E , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 4.3 weeks | Korb E , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 4.3 weeks | Korb E , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Communications | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Developmental profile | Integumentary system development | Side effect | Immunohistochemistry | Not specified | Korb E , et al. (2017) |
Developmental profile | Digestive system development | No adverse effect | Immunohistochemistry | Not specified | Korb E , et al. (2017) |
Emotion | Exploratory activity | No adverse effect | Three-chamber social approach test | 4.3 weeks | Korb E , et al. (2017) |
Immune response | Adaptive immune response: t cells | Side effect | Flow cytometric analysis | Not specified | Korb E , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Molecular profile | Gene expression | Ameliorated | Quantitative pcr (qrt-pcr) | Not specified | Korb E , et al. (2017) |
M_FMR1_1_KO_HM_JQ1_CX
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 homozygous null mice were treated daily by intraperitoneal injections for 1 week before testing began with either DMSO alone or 5 mg/kg each of JQ1 and CX-4945 combined, dissolved in DMSO, and diluted 1:10 into cyclodextrin.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Refractory | Open field test | 4-8 weeks | Korb E , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Refractory | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Immunohistochemistry | 4-8 weeks | Korb E , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 4-8 weeks | Korb E , et al. (2017) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 4-8 weeks | Korb E , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 4-8 weeks | Korb E , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Communications | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Emotion | Anxiety | Restored | Open field test | 5 weeks | Korb E , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Korb E , et al. (2017) |
Molecular profile | Gene expression | Ameliorated | Quantitative pcr (qrt-pcr) | 4-8 weeks | Korb E , et al. (2017) |
Molecular profile | Gene expression | Restored | Quantitative pcr (qrt-pcr) | 4-8 weeks | Korb E , et al. (2017) |
M_FMR1_1_KO_HM_LITHIUM-ACUTE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 KO mice were given an intraperitoneal (ip) injection of 4 mmole/kg lithium chloride (Sigma), for the acute treatment with lithium a dose that is effective in behavioral tests and increases serinephosphorylation of GSK3 in mouse brain.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Communications | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Developmental profile | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Sustained effect | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Sustained effect | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Sustained effect | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
M_FMR1_1_KO_HM_LITHIUM-CHRONIC
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 KO mice were given water and saline ad libitum and were fed pelleted chow containing 0.2% lithium carbonate (Teklad, Madison, WI) for three weeks for the chronic treatment with lithium.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Neurophysiology | Neurotransmitter release: neurotrophins | Unexpected results | Elisa | 3 months | Yuskaitis CJ , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Communications | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Developmental profile | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Learning & memory | Cued or contextual fear conditioning: passive avoidance | Restored | Passive avoidance test | 3 months | Yuskaitis CJ , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
M_FMR1_1_KO_HM_LPS
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous; hemizygous
Mutation:
FMR1 mutant mice were treated with lipopolysaccharide (50microgram/kg, i.p., acute)
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J
Es cell line: E14
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | () |
Motor phenotype | NA | Not reported | NA | NA | () |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | () |
Neurophysiology | Neuronal activation | Refractory | Immunohistochemistry | Adult | () |
Repetitive behavior | NA | Not reported | NA | NA | () |
Seizure | NA | Not reported | NA | NA | () |
Sensory | NA | Not reported | NA | NA | () |
Social behavior | Social approach | Refractory | Three-chamber social approach test | Adult | () |
Physiological parameters | NA | Not reported | NA | NA | () |
Communications | NA | Not reported | NA | NA | () |
Developmental profile | NA | Not reported | NA | NA | () |
Emotion | NA | Not reported | NA | NA | () |
Immune response | Cytokine levels: pro-inflammatory | Side effect | Elisa | Adult, 2-5 months, 9-12 months | () |
Learning & memory | NA | Not reported | NA | NA | () |
Maternal behavior | NA | Not reported | NA | NA | () |
Molecular profile | NA | Not reported | NA | NA | () |
M_FMR1_1_KO_HM_MINOCYCLINE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo) with 30 mg/kg minocycline mother's drinking water for 28 days.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: Not Specified
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Motor phenotype | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Communications | Ultrasonic vocalization | Restored | Monitoring ultrasonic vocalizations | NA | Rotschafer SE , et al. (2012) |
Communications | Ultrasonic vocalization | No adverse effect | Monitoring ultrasonic vocalizations | Unreported | Rotschafer SE , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Molecular profile | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
M_FMR1_1_KO_HM_MINOCYCLINE-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo) with 30 mg/kg minocycline mother's drinking water for 28 days.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: Not Specified
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Motor phenotype | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Communications | Ultrasonic vocalization | Restored | Monitoring ultrasonic vocalizations | NA | Rotschafer SE , et al. (2012) |
Communications | Ultrasonic vocalization | No adverse effect | Monitoring ultrasonic vocalizations | Unreported | Rotschafer SE , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
Molecular profile | NA | Not reported | NA | NA | Rotschafer SE , et al. (2012) |
M_FMR1_1_KO_HM_MINOCYCLINE-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Female FMR1 heterozygous mice and their pups were treated with minocycline through drinking water at 30mg/kg/day. After the offspring were weaned, minocycline administration continued in the drinking water of the offspring until they reached 2 months of age. FMR1 hemizygous knockout mice where a neomycin resistance gene is inserted into exon 5 and there is no detectable transcript or protein produced by this allele. .
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J
Es cell line: E14
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Western blot | Adult | Yau SY , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Restored | Sholl analysis | Adult | Yau SY , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Restored | Sholl analysis | Adult | Yau SY , et al. (2018) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | Restored | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Restored | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No adverse effect | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Epsp-spike relationship | Restored | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Neurophysiology | Epsp-spike relationship | Side effect | Whole-cell voltage clamp | Adult | Yau SY , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Communications | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Emotion | Exploratory activity: habituation | No adverse effect | Object-place recognition test | Adult | Yau SY , et al. (2018) |
Emotion | Depression | No adverse effect | Forced swim test | Adult | Yau SY , et al. (2018) |
Emotion | Depression | No adverse effect | Tail suspension test | Adult | Yau SY , et al. (2018) |
Emotion | Anxiety | Side effect | Open field test | Adult | Yau SY , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Learning & memory | Spatial reference memory | Restored | Object-place recognition test | Adult | Yau SY , et al. (2018) |
Learning & memory | Procedural learning | No adverse effect | Novel object recognition test | Adult | Yau SY , et al. (2018) |
Learning & memory | Object recognition memory | Restored | Novel object recognition test | Adult | Yau SY , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Yau SY , et al. (2018) |
Molecular profile | Protein phosphorylation | Restored | Western blot | Adult | Yau SY , et al. (2018) |
Molecular profile | Protein localization: synapse | Restored | Western blot | Adult | Yau SY , et al. (2018) |
M_FMR1_1_KO_HM_MPEP
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
FMR1 KO mice were given an intraperitoneal (ip) injection of 30mg/kg MPEP (2-methyl-6-phenylethynyl-pyridine), for the acute treatment with lithium a dose that is effective in behavioral tests and increases serinephosphorylation of GSK3 in mouse brain.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Communications | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Developmental profile | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3 months | Yuskaitis CJ , et al. (2009) |
M_FMR1_1_KO_HM_S1DZ-INACT
Model Type: RESCUE-Procedural
Model Genotype: Homozygous
Mutation:
Neural activity was optogenetically suppressed in the primary somatosensory cortex dysgranular zone in Fmr1 mutant mice.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: C57BL/6J
Es cell line: E14
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | () |
Motor phenotype | NA | Not reported | NA | NA | () |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | () |
Neurophysiology | NA | Not reported | NA | NA | () |
Repetitive behavior | NA | Not reported | NA | NA | () |
Seizure | NA | Not reported | NA | NA | () |
Sensory | NA | Not reported | NA | NA | () |
Social behavior | Social approach | Restored | Three-chamber social approach test | Adult | () |
Physiological parameters | NA | Not reported | NA | NA | () |
Communications | NA | Not reported | NA | NA | () |
Developmental profile | NA | Not reported | NA | NA | () |
Emotion | NA | Not reported | NA | NA | () |
Immune response | NA | Not reported | NA | NA | () |
Learning & memory | NA | Not reported | NA | NA | () |
Maternal behavior | NA | Not reported | NA | NA | () |
Molecular profile | NA | Not reported | NA | NA | () |
M_FMR1_2_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
FMR1 gene was generated by construction a targeting vector using homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin (neo).
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: Not Specified
Es cell line: E14
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | no authors (1994) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Motor phenotype | Spontaneous movement | Increased | Home cage behavior | Unreported | no authors (1994) |
Motor phenotype | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Motor phenotype | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Motor phenotype | General locomotor activity | No change | Open field test | 3 months | Olmos-Serrano JL , et al. (2011) |
Motor phenotype | General locomotor activity | Increased | Open field test | 3 months | Olmos-Serrano JL , et al. (2011) |
Motor phenotype | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Macroscopic analysis | 2 months | no authors (1994) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | no authors (1994) |
Neurophysiology | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Neurophysiology | Miniature post synaptic currents: excitatory | Increased | Whole-cell patch clamp | P0-p1 | Costa L , et al. (2012) |
Neurophysiology | Miniature post synaptic currents: excitatory | Decreased | Whole-cell patch clamp | P0-p1 | Costa L , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Neurophysiology | Synaptic transmission | Decreased | Field potential recordings | Unreported | Shang Y , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | no authors (1994) |
Repetitive behavior | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Repetitive behavior | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Seizure | NA | Not reported | NA | NA | no authors (1994) |
Seizure | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Seizure | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Sensory | NA | Not reported | NA | NA | no authors (1994) |
Sensory | Touch | Increased | Response to air puff | 6-8 weeks | Orefice LL , et al. (2016) |
Sensory | Tactile memory | Decreased | Textured novel object recognition test (t-nort) | 6-8 weeks | Orefice LL , et al. (2016) |
Sensory | Startle response: acoustic stimulus | No change | Acoustic startle reflex test | 6-8 weeks | Orefice LL , et al. (2016) |
Sensory | Sensorimotor gating: tactile cue | Decreased | Prepulse inhibition | 6-8 weeks | Orefice LL , et al. (2016) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | 6-8 weeks | Orefice LL , et al. (2016) |
Sensory | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Sensory | Startle response: acoustic stimulus | Decreased | Prepulse inhibition | 3 months | Olmos-Serrano JL , et al. (2011) |
Sensory | Startle response: acoustic stimulus | Decreased | Prepulse inhibition | 3 months | Olmos-Serrano JL , et al. (2011) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | 3 months | Olmos-Serrano JL , et al. (2011) |
Sensory | Sensorimotor gating | Increased | Prepulse inhibition | 3 months | Olmos-Serrano JL , et al. (2011) |
Sensory | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | Unreported | no authors (1994) |
Social behavior | Social interaction | Increased | Light-dark exploration test | Unreported | no authors (1994) |
Social behavior | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Social behavior | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Social behavior | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | no authors (1994) |
Physiological parameters | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Physiological parameters | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Communications | NA | Not reported | NA | NA | no authors (1994) |
Communications | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Communications | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Communications | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Communications | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Developmental profile | Reproductive system development | No change | General observations | Unreported | no authors (1994) |
Developmental profile | Reproductive system development | Decreased | General observations | 5-7 weeks, 2.5 months; 3.5 months; 5.5 months | no authors (1994) |
Developmental profile | Reproductive system development | Decreased | Histology | 5-7 weeks, 2.5 months; 3.5 months; 5.5 months | no authors (1994) |
Developmental profile | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Developmental profile | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Developmental profile | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Emotion | NA | Not reported | NA | NA | no authors (1994) |
Emotion | Exploratory activity | No change | Textured novel object recognition test (t-nort) | 6-8 weeks | Orefice LL , et al. (2016) |
Emotion | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Emotion | Anxiety | No change | Open field test | 3 months | Olmos-Serrano JL , et al. (2011) |
Emotion | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Immune response | NA | Not reported | NA | NA | no authors (1994) |
Immune response | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Immune response | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Learning & memory | Spatial learning | No change | Morris water maze test | Unreported | no authors (1994) |
Learning & memory | Spatial learning | Decreased | Morris water maze test | Unreported | no authors (1994) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | No change | Passive avoidance test | Unreported | no authors (1994) |
Learning & memory | Object recognition memory: long-term recall | Decreased | Novel object recognition test | 6-8 weeks | Orefice LL , et al. (2016) |
Learning & memory | Object recognition memory | No change | Novel object recognition test | 6-8 weeks | Orefice LL , et al. (2016) |
Learning & memory | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Decreased | Fear conditioning test | 3 months | Olmos-Serrano JL , et al. (2011) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Decreased | Fear conditioning test | 3 months | Olmos-Serrano JL , et al. (2011) |
Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 3 months | Olmos-Serrano JL , et al. (2011) |
Learning & memory | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | no authors (1994) |
Maternal behavior | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Maternal behavior | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
Molecular profile | NA | Not reported | NA | NA | no authors (1994) |
Molecular profile | NA | Not reported | NA | NA | Orefice LL , et al. (2016) |
Molecular profile | NA | Not reported | NA | NA | Costa L , et al. (2012) |
Molecular profile | NA | Not reported | NA | NA | Olmos-Serrano JL , et al. (2011) |
Molecular profile | NA | Not reported | NA | NA | Shang Y , et al. (2009) |
M_FMR1_2_KO_HM_CTEP-A
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination mediated targeting against Exon 5 of Fmr1 followed by acute treatment of CTEP of 2 mg/kg per os (s.c.) 24 hr prior.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Motor phenotype | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Neurophysiology | Synaptic plasticity: ltd | Restored | Field potential recordings | P25-p30 | Michalon A , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Seizure | Seizures | Restored | Acoustic startle reflex test | P18-p22 | Michalon A , et al. (2012) |
Seizure | Seizures | Ameliorated | Acoustic startle reflex test | 1-2 months | Michalon A , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Molecular profile | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
M_FMR1_2_KO_HM_CTEP-C
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination mediated targeting against Exon 5 of Fmr1 followed by chronic treatment of CTEP.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Motor phenotype | Motor coordination and balance | No adverse effect | Accelerating rotarod test | Unreported | Michalon A , et al. (2012) |
Motor phenotype | Grip strength | Refractory | Grip strength test | 9 weeks | Michalon A , et al. (2012) |
Motor phenotype | General locomotor activity | Restored | Open field test | 2-5 months | Michalon A , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Golgi-cox staining | P58-p63 | Michalon A , et al. (2012) |
Neurophysiology | Synaptic plasticity | Restored | Field potential recordings | P58-p65 | Michalon A , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Sensory | Startle response: acoustic stimulus | Restored | Acoustic startle reflex test | P58-p63 | Michalon A , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Developmental profile | Tissue weight | Ameliorated | General observations | 5-17 weeks | Michalon A , et al. (2012) |
Developmental profile | Size/growth | Side effect | General observations | Unreported | Michalon A , et al. (2012) |
Developmental profile | Developmental trajectory | Restored | Irwin battery of neurological tests | 9 weeks | Michalon A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Restored | Passive avoidance test | P58-p63 | Michalon A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Michalon A , et al. (2012) |
Molecular profile | Signaling | Restored | Western blot | P58-p63 | Michalon A , et al. (2012) |
M_FMR1_3_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
A germline null mutation was created by crossing FMR1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Gene inactivation was confirmed by a lack of protein expression in the brain and testes as determined by immunoblot analysis.
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: 129P2/OlaHsd * C57BL/6
Es cell line: E14
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Motor phenotype | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neurotransporter expression | Decreased | Immunocytochemistry | P15 | Tyzio R , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Neurophysiology | Spontaneous post synaptic events | Increased | Whole-cell patch clamp | P0, p15 | Tyzio R , et al. (2014) |
Neurophysiology | Population spikes | Increased | Field potential recordings | P15 | Tyzio R , et al. (2014) |
Neurophysiology | Driving force of ion channel or receptor | Increased | Cell-attached patch clamp | E20-e21, p15, p30 | Tyzio R , et al. (2014) |
Neurophysiology | Action potential property: firing rate | Increased | Cell-attached patch clamp | P0 | Tyzio R , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Repetitive behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Seizure | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Sensory | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Social behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Physiological parameters | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Communications | Ultrasonic vocalization | Decreased | Monitoring ultrasonic vocalizations | P8 | Tyzio R , et al. (2014) |
Communications | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Developmental profile | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Developmental profile | Reproductive system development | Decreased | Measurement of tissue weight | Unreported | Mientjes EJ , et al. (2005) |
Developmental profile | General characteristics | No change | General observations | Unreported | Mientjes EJ , et al. (2005) |
Developmental profile | General characteristics | No change | General observations | Unreported | Mientjes EJ , et al. (2005) |
Emotion | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Immune response | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Learning & memory | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Maternal behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Molecular profile | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Molecular profile | Targeted expression | Decreased | Immunocytochemistry | Unreported | Mientjes EJ , et al. (2005) |
Molecular profile | Targeted expression | Decreased | Western blot | Unreported | Mientjes EJ , et al. (2005) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | Unreported | Mientjes EJ , et al. (2005) |
M_FMR1_3_KO_HM-BUMETANIDE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
A germline null mutation was created by crossing FMR1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Dams were treated with Bumetanide (2-2.5 mg/kg) in drinking water, one day before delivery.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: 129P2/OlaHsd * C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Neurophysiology | Spontaneous post synaptic events | Ameliorated | Whole-cell patch clamp | P15 | Tyzio R , et al. (2014) |
Neurophysiology | Population spikes | Ameliorated | Field potential recordings | P15 | Tyzio R , et al. (2014) |
Neurophysiology | Driving force of ion channel or receptor | Restored | Cell-attached patch clamp | P15 | Tyzio R , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Communications | Ultrasonic vocalization | Restored | Monitoring ultrasonic vocalizations | P8 | Tyzio R , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
M_FMR1_3_KO_HM_BUMETANIDE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
A germline null mutation was created by crossing Fmr1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Dams were treated with Bumetanide (2-2.5 mg/kg) in drinking water, one day before delivery.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd
Genetic Background: 129P2/OlaHsd * C57BL/6
Es cell line: -
Model Source: JAX
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Neurophysiology | Spontaneous post synaptic events | Ameliorated | Whole-cell patch clamp | P15 | Tyzio R , et al. (2014) |
Neurophysiology | Population spikes | Ameliorated | Field potential recordings | P15 | Tyzio R , et al. (2014) |
Neurophysiology | Driving force of ion channel or receptor | Restored | Cell-attached patch clamp | P15 | Tyzio R , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Communications | Ultrasonic vocalization | Restored | Monitoring ultrasonic vocalizations | P8 | Tyzio R , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Tyzio R , et al. (2014) |
M_FMR1_4_CKO_HM_PURKINJEN
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 1 of FMR1 using L7-cre, in Purkinje cells of the cerebellum
Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6J
Genetic Background: Not specified
Es cell line: E14
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Motor phenotype | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Neurophysiology | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Repetitive behavior | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Seizure | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Sensory | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Social behavior | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Physiological parameters | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Communications | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Developmental profile | Reproductive system development | Decreased | General observations | Unreported | Mientjes EJ , et al. (2005) |
Developmental profile | General characteristics | No change | General observations | Unreported | Mientjes EJ , et al. (2005) |
Emotion | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Immune response | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Learning & memory | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Maternal behavior | NA | Not reported | NA | NA | Mientjes EJ , et al. (2005) |
Molecular profile | Targeted expression | Decreased | Immunohistochemistry | Unreported | Mientjes EJ , et al. (2005) |
M_FMR1_5_KI_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Knock in of transgene containing ~120 CGG.CCG repeats in the FMR1 gene with a Cre recombinase under the control of the MMTV promoter.
Allele Type: Humanized LOF mutation
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | Unreported | Qin M , et al. (2011) |
Motor phenotype | General locomotor activity | Increased | Open field test | 7-9 weeks | Qin M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Golgi-cox staining | 17 weeks | Qin M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Golgi-cox staining | 17 weeks | Qin M , et al. (2011) |
Neurophysiology | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Sensory | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8-10 weeks | Qin M , et al. (2011) |
Social behavior | Social approach | No change | Three-chamber social approach test | 8-10 weeks | Qin M , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Communications | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Developmental profile | Size/growth | No change | General observations | Unreported | Qin M , et al. (2011) |
Developmental profile | Reproductive system development | Decreased | Measurement of tissue weight | NA | Qin M , et al. (2011) |
Developmental profile | General characteristics | No change | General observations | Unreported | Qin M , et al. (2011) |
Emotion | Anxiety | Decreased | Elevated zero maze test | 10-13 weeks | Qin M , et al. (2011) |
Emotion | Anxiety | Decreased | Open field test | 10-13 weeks | Qin M , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Learning & memory | Cued or contextual fear conditioning: passive avoidance | Decreased | Passive avoidance test | 13-16 weeks | Qin M , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Qin M , et al. (2011) |
Molecular profile | Regulation of translation | Increased | Autoradiographic analysis | 17 weeks | Qin M , et al. (2011) |
Molecular profile | Protein expression level evidence | Decreased | Western blot | 3 months | Qin M , et al. (2011) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 3 months | Qin M , et al. (2011) |
M_FMR1_6_KI_HM_I304N
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Homologous recombination mediated introduction of I304N mutation to FMR1 locus.
Allele Type: Humanized LOF mutation
Strain of Origin: Not Specified
Genetic Background: FVB x C57BL/6J
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Motor phenotype | Hyperactivity | No change | Open field test | Unreported | Zang JB , et al. (2009) |
Motor phenotype | General locomotor activity | Increased | Open field test | Unreported | Zang JB , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Repetitive behavior | Repetitive digging | Increased | Marble-burying test | Unreported | Zang JB , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | Unreported | Zang JB , et al. (2009) |
Sensory | Pain or nociception | Decreased | Hot plate test | Unreported | Zang JB , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Communications | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Developmental profile | Size/growth | No change | General observations | Unreported | Zang JB , et al. (2009) |
Developmental profile | Reproductive system development | Increased | General observations | Unreported | Zang JB , et al. (2009) |
Developmental profile | General characteristics | No change | General observations | Unreported | Zang JB , et al. (2009) |
Emotion | Anxiety | Decreased | Open field test | Unreported | Zang JB , et al. (2009) |
Emotion | Anxiety | Decreased | Light-dark exploration test | Unreported | Zang JB , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
Molecular profile | NA | Not reported | NA | NA | Zang JB , et al. (2009) |
M_FMR1_7_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin, maintained in a mixed background with FVB and 129P2 corrected for eyesight by the pde6b allele.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: FVB.129P2.pde6b+
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | - |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | - |
Motor phenotype | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Motor phenotype | General locomotor activity | Increased | Elevated plus maze test | 4, 8 weeks | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Increased | Open field test | 4, 8 weeks | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Increased | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | - |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No change | Golgi-cox staining | 11 weeks | Dolan BM , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Golgi-cox staining | 11 weeks | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Neurophysiology | Neuronal activation | No change | Whole-cell voltage clamp | P17-p23 | - |
Neurophysiology | Synaptic transmission | Increased | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Synaptic plasticity | No change | Whole-cell current clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Stimulus-spike relationship: inhibitory | Decreased | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Spontaneous post synaptic event frequency: inhibitory currents | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Network excitability | No change | Whole-cell current clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Network excitability | Decreased | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Membrane potential | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Intrinsic membrane properties | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Epsp-spike relationship | Decreased | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Decay kinetics of miniature post synaptic currents | No change | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Decay kinetics of miniature post synaptic currents | No change | Whole-cell current clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: rate of depolarization | No change | Whole-cell current clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: firing rate | Decreased | Whole-cell voltage clamp | P42-p92 | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: firing rate | No change | Whole-cell voltage clamp | 2.5 weeks - 3.14 weeks, 2 months | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: firing rate | No change | Cell-attached patch clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: firing rate | No change | Whole-cell current clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: firing rate | Increased | Whole-cell voltage clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | Action potential property: amplitude | No change | Whole-cell current clamp | P17-p23 | Antoine MW , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | Neurotransmitter release: catecholamines | Decreased | In vivo amperometry | Unreported | Rogers TD , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | - |
Repetitive behavior | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Repetitive behavior | Stereotypy | Increased | Open field test | Unreported | Dansie LE , et al. (2013) |
Repetitive behavior | Repetitive digging | Increased | Marble-burying test | 4, 8 weeks, 2 months | Dansie LE , et al. (2013) |
Repetitive behavior | Stereotypy | Increased | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Repetitive behavior | Circling | Increased | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Seizure | NA | Not reported | NA | NA | - |
Seizure | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Seizure | Seizures | Increased | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Seizure | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Sensory | NA | Not reported | NA | NA | - |
Sensory | Sensory-evoked response: excitation: tactile stimulus | Decreased | Whole-cell voltage clamp | P42-p92 | Antoine MW , et al. (2019) |
Sensory | Sensory-evoked response: excitation: tactile stimulus | Decreased | Whole-cell voltage clamp | 2.5 weeks - 3.14 weeks, 2 months | Antoine MW , et al. (2019) |
Sensory | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Sensory | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | - |
Social behavior | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Social behavior | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | - |
Physiological parameters | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Communications | NA | Not reported | NA | NA | - |
Communications | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Communications | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | - |
Developmental profile | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Developmental profile | Tissue weight | Increased | General observations | 10-17 weeks | Dolan BM , et al. (2013) |
Developmental profile | Size/growth | No change | General observations | 10-17 weeks | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Emotion | NA | Not reported | NA | NA | - |
Emotion | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Emotion | Anxiety | Increased | Elevated plus maze test | 4, 8 weeks | Dansie LE , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Immune response | NA | Not reported | NA | NA | - |
Immune response | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Immune response | Adaptive immune response: b cells antibody production: igg | No change | Elisa | Unreported | Dansie LE , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | - |
Learning & memory | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Learning & memory | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | - |
Maternal behavior | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | - |
Molecular profile | NA | Not reported | NA | NA | Antoine MW , et al. (2019) |
Molecular profile | Protein phosphorylation | Increased | Elisa | Unreported | Dansie LE , et al. (2013) |
Molecular profile | Protein phosphorylation | Decreased | Elisa | Unreported | Dansie LE , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Rogers TD , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486-H
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 30 mg/kg for 8 hours.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Restored | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486-L-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 8 hours.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486-L-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 5 days and tested 8 hrs after final dose.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486-M-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 8 hours.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No adverse effect | Golgi-cox staining | 11 weeks | Dolan BM , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Golgi-cox staining | 11 weeks | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486-M-3
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 5 days and tested 8 hours after final dose.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | Motor coordination and balance | No adverse effect | Accelerating rotarod test | 10-17 weeks | Dolan BM , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | Stereotypy | Restored | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Repetitive behavior | Circling | Restored | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Seizure | Seizures | Restored | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | Tissue weight | Refractory | General observations | 10-17 weeks | Dolan BM , et al. (2013) |
Developmental profile | Size/growth | No adverse effect | General observations | 10-17 weeks | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_H
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 30 mg/kg for 8 hours.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Restored | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_L
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 8 hours.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_L_D
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 10 mg/kg for 5 days and tested 8 hrs after final dose.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_M
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 8 hours.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No adverse effect | Golgi-cox staining | 11 weeks | Dolan BM , et al. (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Golgi-cox staining | 11 weeks | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_M-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for one dose and tested 5 days after.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Refractory | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_M_D
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for 5 days and tested 8 hours after final dose.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | Motor coordination and balance | No adverse effect | Accelerating rotarod test | 10-17 weeks | Dolan BM , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | Stereotypy | Restored | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Repetitive behavior | Circling | Restored | Open field test | 10-17 weeks | Dolan BM , et al. (2013) |
Seizure | Seizures | Restored | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | Tissue weight | Refractory | General observations | 10-17 weeks | Dolan BM , et al. (2013) |
Developmental profile | Size/growth | No adverse effect | General observations | 10-17 weeks | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_FRAX486_M_S
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of FRAX486 at 20 mg/kg for one dose and tested 5 days after.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Motor phenotype | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Seizure | Seizures | Refractory | Audiogenic seizure test | 10-17 weeks | Dolan BM , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Emotion | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Immune response | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
Molecular profile | NA | Not reported | NA | NA | Dolan BM , et al. (2013) |
M_FMR1_7_KO_HM_MINOCYCLINE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Homologous recombination against Exon 5 which was interrupted by the positive selection marker gene neomycin followed by administration of minocycline at 30 mg/kg/day in drinking water for 4 or 8 weeks.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: FVB
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Elevated plus maze test | 4, 8 weeks | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Elevated plus maze test | 4, 8 weeks | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Open field test | 4, 8 weeks | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Open field test | 4, 8 weeks | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Refractory | Open field test | >2 months | Dansie LE , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Open field test | >2 months | Dansie LE , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Neurophysiology | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | >2 months | Dansie LE , et al. (2013) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | >2 months | Dansie LE , et al. (2013) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 4, 8 weeks | Dansie LE , et al. (2013) |
Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 4, 8 weeks; 2 months | Dansie LE , et al. (2013) |
Seizure | Seizures | Ameliorated | Audiogenic seizure test | 4 weeks | Dansie LE , et al. (2013) |
Sensory | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Social behavior | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Physiological parameters | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Communications | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Developmental profile | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Emotion | Anxiety | Restored | Elevated plus maze test | 4, 8 weeks | Dansie LE , et al. (2013) |
Emotion | Anxiety | Restored | Elevated plus maze test | 4, 8 weeks | Dansie LE , et al. (2013) |
Immune response | Adaptive immune response: b cells | No adverse effect | Elisa | 10 weeks | Dansie LE , et al. (2013) |
Learning & memory | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Maternal behavior | NA | Not reported | NA | NA | Dansie LE , et al. (2013) |
Molecular profile | Protein phosphorylation | Restored | Elisa | >4 weeks | Dansie LE , et al. (2013) |
Molecular profile | Protein phosphorylation | Refractory | Elisa | >4 weeks | Dansie LE , et al. (2013) |
M_FMR1_8_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
FMR1 KO mice were originally on the C57Bl/6 background but to generate phenotyped in a mixed C57BL/6 129SveJ background form litters.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6.129SVeJ
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Motor phenotype | Motor coordination and balance | Decreased | Accelerating rotarod test | Unreported | Bhattacharya A , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Golgi-cox staining | 3-4 months | Bhattacharya A , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Abnormal | Golgi-cox staining | 3-4 months | Bhattacharya A , et al. (2012) |
Neurophysiology | Synaptic plasticity: ltd | Increased | Whole-cell patch clamp | 3-5 weeks | Bhattacharya A , et al. (2012) |
Repetitive behavior | Stereotypy | Increased | Marble-burying test | Unreported | Bhattacharya A , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | Unreported | Bhattacharya A , et al. (2012) |
Social behavior | Social interaction | Increased | Open field test | Unreported | Bhattacharya A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Developmental profile | Size/growth | Increased | General observations | 6 weeks | Bhattacharya A , et al. (2012) |
Developmental profile | Reproductive system development | Decreased | General observations | 3-4 months | Bhattacharya A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Learning & memory | Spatial working memory | No change | Water y-maze test | Unreported | Bhattacharya A , et al. (2012) |
Learning & memory | Spatial working memory | Decreased | Water y-maze test | Unreported | Bhattacharya A , et al. (2012) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | Unreported | Bhattacharya A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Molecular profile | Regulation of translation | Increased | Surface sensing of translation (sunset) | Unreported | Bhattacharya A , et al. (2012) |
Molecular profile | Protein phosphorylation | Increased | Western blot | Unreported | Bhattacharya A , et al. (2012) |
Molecular profile | Protein modification process | Increased | Immunohistochemistry | 8-10 weeks | Bhattacharya A , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Western blot | Unreported | Bhattacharya A , et al. (2012) |
Molecular profile | Protein expression level evidence | Increased | Western blot | Unreported | Bhattacharya A , et al. (2012) |
M_FMR1_8_KO_HM_S6K1_DM-HM
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
FMR1 KO were crossed with homozygous S6K1 KO mice to produce double knockout, maintained in the mixed background. As they used males, FMR1 was hemizygous.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6.129SVeJ
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Motor phenotype | Motor coordination and balance | Restored | Accelerating rotarod test | 4-6 months | Bhattacharya A , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Golgi-cox staining | P90-p100 | Bhattacharya A , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Golgi-cox staining | P90-p100 | Bhattacharya A , et al. (2012) |
Neurophysiology | Synaptic plasticity: ltd | Restored | Whole-cell patch clamp | P23-p35 | Bhattacharya A , et al. (2012) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No adverse effect | Whole-cell patch clamp | 3-5 weeks | Bhattacharya A , et al. (2012) |
Repetitive behavior | Stereotypy | Refractory | Marble-burying test | 4-6 months | Bhattacharya A , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Social behavior | Social interaction | Refractory | Open field test | 4-6 months | Bhattacharya A , et al. (2012) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 4-6 months | Bhattacharya A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Developmental profile | Size/growth | Restored | General observations | P28-p84 | Bhattacharya A , et al. (2012) |
Developmental profile | General characteristics | No adverse effect | General observations | Unreported | Bhattacharya A , et al. (2012) |
Developmental profile | Developmental trajectory | Restored | General observations | P90-p100 | Bhattacharya A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Learning & memory | Spatial working memory | Restored | Water y-maze test | 4-6 months | Bhattacharya A , et al. (2012) |
Learning & memory | Spatial working memory | No adverse effect | Water y-maze test | 4-6 months | Bhattacharya A , et al. (2012) |
Learning & memory | Object recognition memory | Restored | Novel object recognition test | 4-6 months | Bhattacharya A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Molecular profile | Regulation of translation | Restored | Surface sensing of translation (sunset) | 4-6 weeks | Bhattacharya A , et al. (2012) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 2 months | Bhattacharya A , et al. (2012) |
Molecular profile | Protein phosphorylation | Restored | Immunohistochemistry | 8-10 weeks | Bhattacharya A , et al. (2012) |
Molecular profile | Protein expression level evidence | Refractory | Western blot | 2 months | Bhattacharya A , et al. (2012) |
Molecular profile | Protein expression level evidence | Restored | Western blot | 2 months | Bhattacharya A , et al. (2012) |
M_FMR1_8_KO_HM_S6K1_DM-HT
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
FMR1 KO were crossed with homozygous S6K1 KO mice to produce double knockout, maintained in the mixed background. As they used males, FMR1 was hemizygous.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: C57BL/6.129SVeJ
Es cell line: Not specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Motor phenotype | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Neurophysiology | Synaptic plasticity: ltd | Refractory | Whole-cell patch clamp | P23-p35 | Bhattacharya A , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Communications | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Bhattacharya A , et al. (2012) |
Molecular profile | Protein phosphorylation | Refractory | Western blot | 3-4 months | Bhattacharya A , et al. (2012) |
M_FMR1_9_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
FMR1 KO mice, floxed at exon 5, maintained in the mixed background of C57Bl/6 and 129P2.
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6.129P2
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Motor phenotype | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | Decreased | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Increased | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Decreased | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Increased | Cell size measurement | 12 months | Selby L , et al. (2007) |
Neurophysiology | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Social behavior | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Physiological parameters | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Communications | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Developmental profile | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Learning & memory | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Selby L , et al. (2007) |
Molecular profile | Protein expression level evidence | Increased | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
Molecular profile | Protein expression level evidence | Decreased | Immunohistochemistry | 12 months | Selby L , et al. (2007) |
M_SYNGAP1_9_KO_FMR1_DM
Model Type: Genetic
Model Genotype: Hemizygous (Fmr1), heterozygous (Syngap1)
Mutation:
Syngap1 het mice were mated with FMR1-/+ females to get FMR1-/y:Syngap1+/- mice.
Allele Type: Knockout
Strain of Origin: 129P2/OlaHsd*C57BL/6JOla
Genetic Background: -
Es cell line: -
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Motor phenotype | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Neurophysiology | Synaptic plasticity: hippocampal ltd | Increased | Field potential recordings | 3-4.5 weeks | Barnes SA , et al. (2015) |
Repetitive behavior | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Seizure | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Sensory | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Social behavior | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Physiological parameters | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Communications | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Developmental profile | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Emotion | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Immune response | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Learning & memory | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Maternal behavior | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Molecular profile | NA | Not reported | NA | NA | Barnes SA , et al. (2015) |
Other FMR1 Rescue Models(24 Models)
M_FMR1_1_KO_HM | 2 | Genetic | Pharmaceutical | BW-723C86;MDL-11,939 |
M_FMR1_1_KO_HM | 1 | Genetic | Pharmaceutical | BW-723C86;MDL-11,939;SKF-81,297;Sulpiride |
M_FMR1_1_KO_HM | 1 | Genetic | Genetic | inactivation of one allele of App gene |
M_FMR1_1_KO_HM | 2 | Genetic | Pharmaceutical | CTEP |
M_FMR1_1_KO_HM | 1 | Genetic | Pharmaceutical | CX-4945 |
M_FMR1_1_KO_HM | 2 | Genetic | Pharmaceutical | SKF-81,297;Sulpiride |
M_FMR1_1_KO_HM | 1 | Genetic | Pharmaceutical | Recombinant interleukin 17a |
M_FMR1_1_KO_HM | 3 | Genetic | Pharmaceutical | JQ1 |
M_FMR1_1_KO_HM | 1 | Genetic | Pharmaceutical | CX-4945;JQ1 |
M_FMR1_1_KO_HM | 2 | Genetic | Pharmaceutical | Lithium |
M_FMR1_1_KO_HM | 1 | Genetic | Pharmaceutical | Lipopolysaccharide |
M_FMR1_1_KO_HM | 3 | Genetic | Pharmaceutical | Minocycline |
M_FMR1_1_KO_HM | 1 | Genetic | Pharmaceutical | MPEP |
M_FMR1_1_KO_HM | 1 | Genetic | Procedural | Primary somatosensory cortex dysgranular zone (S1DZ) optogenetic inactivation |
M_FMR1_3_KO_HM | 2 | Genetic | Pharmaceutical | Bumetanide |
M_FMR1_2_KO_HM | 2 | Genetic | Pharmaceutical | CTEP |
M_FMR1_11_KO_HM | 2 | Genetic | Pharmaceutical | Cyclosporine-A |
M_FMR1_11_KO_HM | 1 | Genetic | Pharmaceutical | Dexpramipexole |
M_FMR1_8_KO_HM | 1 | Genetic | Genetic | inactivation of S6K1 gene |
M_FMR1_8_KO_HM | 1 | Genetic | Genetic | inactivation of one copy of S6K1 |
M_FMR1_7_KO_HM | 12 | Genetic | Pharmaceutical | FRAX486 |
M_FMR1_7_KO_HM | 1 | Genetic | Pharmaceutical | Minocycline |
M_FMR1_14_KO_HE | 1 | Genetic | Pharmaceutical | Isoguvacine |
M_FMR1_15_KO_HM | 1 | Genetic LOF | Pharmaceutical | Bryostatin1 |
CNVs associated with FMR1(1 Models)
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Xq27.3 | 13 | Deletion-Duplication | 21 / 114 |