Genetic Mouse Models / KCTD13

KCTD13 potassium channel tetramerization domain containing 13

Model Species
Mus musculus
Gene Aliases
1500003N18Rik, AV259508, PDIP1alpha, Pdip1, Poldip1
Reports
2
Associated Human Genes
KCTD13
Models / Rescue Models
-
Rescue Model
-
Model Summary

KCTD13 knockout mice exhibit reduced synaptic transmission in the CA1 hippocampus, increased RhoA expression, and no effect on brain size or neurogenesis. RhoA inhibition rescues synaptic transmission in KCTD13 mutant mice (Escamilla CO, et. al., Nature, 2017).

Reports related to KCTD13 (2 Reports)
# Type Title Author, Year
1 Primary Kctd13 deletion reduces synaptic transmission via increased RhoA. Escamilla CO , et al. (2017)
2 Additional Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions. Arbogast T , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

M_KCTD13_1_HT_KO

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

One allele of Kctd13 was replaced entirely from the second reading frame to seventeenth base pair after stop codon of the gene, (total 16,080 bp).with a lacz-neo cassette. The neo positive selection marker was deleted using a germline Cre driver.

Allele Type: Knockout
Strain of Origin: C57BL/6NTac*c57BL/6*B6.C-Tg(CMV-Cre),Cgn/J
Genetic Background: -

Es cell line: -
Model Source: Knockout Mouse Project (KOMP) Repository, University of California, Davis (PMID 29088697)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Escamilla CO , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Escamilla CO , et al. (2017)
Motor phenotype Swimming ability No change Morris water maze test 10-19 weeks Escamilla CO , et al. (2017)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 10-19 weeks Escamilla CO , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Increased Home cage behavior 10-19 weeks Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Sholl analysis Not reported Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis Not reported Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Sholl analysis Not reported Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination No change Immunohistochemistry E15, 2.4 weeks Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cell proliferation: neural precursors No change Immunohistochemistry 12 weeks, e15.5 Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) 12 weeks, p7 Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Gross necroscopy 12 weeks, p7 Escamilla CO , et al. (2017)
Neurophysiology Synaptic transmission Decreased Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Paired-pulse ratio P14-17 Escamilla CO , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Local field potential Decreased In vivo local field potential (lfp) recordings 4-6 weeks Escamilla CO , et al. (2017)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 10-19 weeks Escamilla CO , et al. (2017)
Repetitive behavior Repetitive digging No change Marble-burying test 10-19 weeks Escamilla CO , et al. (2017)
Seizure NA Not reported NA NA Escamilla CO , et al. (2017)
Sensory Sensorimotor gating No change Acoustic startle reflex test 10-19 weeks Escamilla CO , et al. (2017)
Sensory Pain or nociception No change Hot plate test 10-19 weeks Escamilla CO , et al. (2017)
Sensory Olfaction No change Buried food test 10-19 weeks Escamilla CO , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test 10-19 weeks Escamilla CO , et al. (2017)
Social behavior Nest building behavior No change Nest building assay 10-19 weeks Escamilla CO , et al. (2017)
Social behavior Inanimate object preference No change Three-chamber social approach test 10-19 weeks Escamilla CO , et al. (2017)
Communications NA Not reported NA NA Escamilla CO , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 12 weeks Escamilla CO , et al. (2017)
Emotion Anxiety No change Open field test 10-19 weeks Escamilla CO , et al. (2017)
Emotion Anxiety No change Light-dark exploration test 10-19 weeks Escamilla CO , et al. (2017)
Emotion Anxiety No change Elevated plus maze test 10-19 weeks Escamilla CO , et al. (2017)
Immune response NA Not reported NA NA Escamilla CO , et al. (2017)
Learning & memory Spatial working memory No change Object-place recognition test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Spatial reference memory No change Morris water maze test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Spatial learning No change Morris water maze test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Object recognition memory No change Novel object recognition test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 10-19 weeks Escamilla CO , et al. (2017)
Maternal behavior NA Not reported NA NA Escamilla CO , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Not reported Escamilla CO , et al. (2017)
Molecular profile Protein expression level evidence No change Western blot E15; not reported Escamilla CO , et al. (2017)
Molecular profile Protein expression level evidence Increased Western blot P18, 4-6 weeks Escamilla CO , et al. (2017)

M_KCTD13_2_HM_KO

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Both alleles of Kctd13 were replaced entirely from the second reading frame to seventeenth base pair after stop codon of the gene, (total 16,080 bp).with a lacz-neo cassette. The neo positive selection marker was deleted using a germline Cre driver.

Allele Type: Knockout
Strain of Origin: C57BL/6NTac*c57BL/6*B6.C-Tg(CMV-Cre),Cgn/J
Genetic Background: -

Es cell line: -
Model Source: Knockout Mouse Project (KOMP) Repository, University of California, Davis (PMID 29088697)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Escamilla CO , et al. (2017)
Circadian sleep/wake cycle NA Not reported NA NA Escamilla CO , et al. (2017)
Motor phenotype Swimming ability No change Morris water maze test 10-19 weeks Escamilla CO , et al. (2017)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 10-19 weeks Escamilla CO , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Increased Home cage behavior 10-19 weeks Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Sholl analysis Not reported Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis Not reported Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Sholl analysis Not reported Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination No change Immunohistochemistry E15, 2.4 weeks Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cell proliferation: neural precursors No change Immunohistochemistry 12 weeks, e15.5 Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) 12 weeks, p7 Escamilla CO , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Gross necroscopy 12 weeks, p7 Escamilla CO , et al. (2017)
Neurophysiology Synaptic transmission Decreased Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Paired-pulse ratio P14-17 Escamilla CO , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Neurophysiology Local field potential Decreased In vivo local field potential (lfp) recordings 4-6 weeks Escamilla CO , et al. (2017)
Neurophysiology Decay kinetics of miniature post synaptic currents No change Whole-cell patch clamp P14-17 Escamilla CO , et al. (2017)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 10-19 weeks Escamilla CO , et al. (2017)
Repetitive behavior Repetitive digging No change Marble-burying test 10-19 weeks Escamilla CO , et al. (2017)
Seizure NA Not reported NA NA Escamilla CO , et al. (2017)
Sensory Sensorimotor gating No change Acoustic startle reflex test 10-19 weeks Escamilla CO , et al. (2017)
Sensory Pain or nociception No change Hot plate test 10-19 weeks Escamilla CO , et al. (2017)
Sensory Olfaction No change Buried food test 10-19 weeks Escamilla CO , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test 10-19 weeks Escamilla CO , et al. (2017)
Social behavior Nest building behavior No change Nest building assay 10-19 weeks Escamilla CO , et al. (2017)
Social behavior Inanimate object preference No change Three-chamber social approach test 10-19 weeks Escamilla CO , et al. (2017)
Communications NA Not reported NA NA Escamilla CO , et al. (2017)
Developmental profile Size/growth Decreased Body weight measurement 12 weeks Escamilla CO , et al. (2017)
Emotion Anxiety No change Open field test 10-19 weeks Escamilla CO , et al. (2017)
Emotion Anxiety No change Light-dark exploration test 10-19 weeks Escamilla CO , et al. (2017)
Emotion Anxiety No change Elevated plus maze test 10-19 weeks Escamilla CO , et al. (2017)
Immune response NA Not reported NA NA Escamilla CO , et al. (2017)
Learning & memory Spatial working memory No change Object-place recognition test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Spatial reference memory No change Morris water maze test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Spatial learning No change Morris water maze test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Object recognition memory No change Novel object recognition test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 10-19 weeks Escamilla CO , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 10-19 weeks Escamilla CO , et al. (2017)
Maternal behavior NA Not reported NA NA Escamilla CO , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Not reported Escamilla CO , et al. (2017)
Molecular profile Targeted expression Decreased Quantitative pcr (qrt-pcr) Not reported Escamilla CO , et al. (2017)
Molecular profile Targeted expression Decreased Immunohistochemistry Not reported Escamilla CO , et al. (2017)
Molecular profile Protein expression level evidence No change Western blot E15; not reported Escamilla CO , et al. (2017)
Molecular profile Protein expression level evidence Increased Western blot P18, 4-6 weeks Escamilla CO , et al. (2017)

M_KCTD13_3_HT_KO

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Kctd13 heterozygous mutants with deletion of exon 2 predicted to introduce a premature stop codon in exon 4 using CMV-Cre expressed ubiquitously.

Allele Type: Knockout
Strain of Origin: C57BL/6N
Genetic Background: C57BL/6N*B6.C-Tg(CMV-cre)1Cgn/J*C57BL/6J

Es cell line: G4 ES cells
Model Source: PMID 30590535; Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Arbogast T , et al. (2018)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: light phase No change Home cage behavior 19 weeks Arbogast T , et al. (2018)
Circadian sleep/wake cycle Adaptation to dark phase No change Home cage behavior 19 weeks Arbogast T , et al. (2018)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 16 weeks Arbogast T , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 12 weeks Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Decreased Golgi-cox staining Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Golgi-cox staining Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change General observations Adult Arbogast T , et al. (2018)
Neurophysiology NA Not reported NA NA Arbogast T , et al. (2018)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 15 weeks Arbogast T , et al. (2018)
Repetitive behavior Self grooming: perseveration No change Induced scratching response 15 weeks Arbogast T , et al. (2018)
Repetitive behavior Repetitive nose pokes No change Hole-board test 13 weeks Arbogast T , et al. (2018)
Repetitive behavior Head bobbing No change Elevated zero maze test 12 weeks Arbogast T , et al. (2018)
Seizure NA Not reported NA NA Arbogast T , et al. (2018)
Sensory Olfaction No change Olfactory discrimination test 16 weeks Arbogast T , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 14 weeks Arbogast T , et al. (2018)
Social behavior Social memory No change Three-chamber social approach test 14 weeks Arbogast T , et al. (2018)
Social behavior Social interaction No change Reciprocal social interaction test 15 weeks Arbogast T , et al. (2018)
Social behavior Social approach No change Three-chamber social approach test 14 weeks Arbogast T , et al. (2018)
Social behavior Rearing behavior No change Open field test 12 weeks Arbogast T , et al. (2018)
Communications NA Not reported NA NA Arbogast T , et al. (2018)
Developmental profile Size/growth No change Body weight measurement 5-14 weeks Arbogast T , et al. (2018)
Developmental profile Mortality/lethality No change Genotypic ratio of progeny from heterozygous parents P0 Arbogast T , et al. (2018)
Emotion Anxiety No change Elevated zero maze test 12 weeks Arbogast T , et al. (2018)
Emotion Anxiety No change Open field test 12 weeks Arbogast T , et al. (2018)
Immune response NA Not reported NA NA Arbogast T , et al. (2018)
Learning & memory Spatial reference memory Decreased Object-place recognition test 15, 16 weeks Arbogast T , et al. (2018)
Learning & memory Spatial reference memory No change Morris water maze test 17-18 weeks Arbogast T , et al. (2018)
Learning & memory Spatial learning No change Morris water maze test 17-18 weeks Arbogast T , et al. (2018)
Learning & memory Object recognition memory Decreased Novel object recognition test 13 weeks Arbogast T , et al. (2018)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 17 weeks Arbogast T , et al. (2018)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 17 weeks Arbogast T , et al. (2018)
Maternal behavior NA Not reported NA NA Arbogast T , et al. (2018)
Molecular profile Targeted expression Decreased Rna sequencing Adult Arbogast T , et al. (2018)
Molecular profile Targeted expression Decreased Western blot P1 Arbogast T , et al. (2018)
Molecular profile Protein expression level evidence No change Western blot P1, 3 weeks, 15 weeks Arbogast T , et al. (2018)
Molecular profile Gene expression Abnormal Rna sequencing Adult Arbogast T , et al. (2018)

M_KCTD13_4_HM_KO

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Kctd13 homozygous mutants with deletion of exon 2 predicted to introduce a premature stop codon in exon 4 using CMV-Cre expressed ubiquitously.

Allele Type: Knockout
Strain of Origin: C57BL/6N
Genetic Background: C57BL/6N*B6.C-Tg(CMV-cre)1Cgn/J*C57BL/6J

Es cell line: G4 ES cells
Model Source: PMID 30590535; Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Arbogast T , et al. (2018)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: light phase No change Home cage behavior 19 weeks Arbogast T , et al. (2018)
Circadian sleep/wake cycle Adaptation to dark phase No change Home cage behavior 19 weeks Arbogast T , et al. (2018)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 16 weeks Arbogast T , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 12 weeks Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Decreased Golgi-cox staining Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Golgi-cox staining Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neurophysiology NA Not reported NA NA Arbogast T , et al. (2018)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 15 weeks Arbogast T , et al. (2018)
Repetitive behavior Self grooming: perseveration No change Induced scratching response 15 weeks Arbogast T , et al. (2018)
Repetitive behavior Repetitive nose pokes No change Hole-board test 13 weeks Arbogast T , et al. (2018)
Repetitive behavior Head bobbing No change Elevated zero maze test 12 weeks Arbogast T , et al. (2018)
Seizure NA Not reported NA NA Arbogast T , et al. (2018)
Sensory Olfaction No change Olfactory discrimination test 16 weeks Arbogast T , et al. (2018)
Social behavior Social memory No change Three-chamber social approach test 14 weeks Arbogast T , et al. (2018)
Social behavior Social interaction No change Reciprocal social interaction test 15 weeks Arbogast T , et al. (2018)
Social behavior Social approach No change Three-chamber social approach test 14 weeks Arbogast T , et al. (2018)
Social behavior Rearing behavior No change Open field test 12 weeks Arbogast T , et al. (2018)
Communications NA Not reported NA NA Arbogast T , et al. (2018)
Developmental profile Size/growth No change Body weight measurement 5-14 weeks Arbogast T , et al. (2018)
Developmental profile Mortality/lethality No change Genotypic ratio of progeny from heterozygous parents P0 Arbogast T , et al. (2018)
Emotion Anxiety No change Elevated zero maze test 12 weeks Arbogast T , et al. (2018)
Emotion Anxiety No change Open field test 12 weeks Arbogast T , et al. (2018)
Immune response NA Not reported NA NA Arbogast T , et al. (2018)
Learning & memory Spatial reference memory Decreased Object-place recognition test 15, 16 weeks Arbogast T , et al. (2018)
Learning & memory Spatial reference memory No change Morris water maze test 17-18 weeks Arbogast T , et al. (2018)
Learning & memory Spatial learning No change Morris water maze test 17-18 weeks Arbogast T , et al. (2018)
Learning & memory Olfactory learning and memory Decreased Social transmission of food preference 14 weeks Arbogast T , et al. (2018)
Learning & memory Object recognition memory Decreased Novel object recognition test 13 weeks Arbogast T , et al. (2018)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 17 weeks Arbogast T , et al. (2018)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 17 weeks Arbogast T , et al. (2018)
Maternal behavior NA Not reported NA NA Arbogast T , et al. (2018)
Molecular profile Targeted expression Decreased Western blot P1 Arbogast T , et al. (2018)
Molecular profile Targeted expression Decreased Rna sequencing Adult Arbogast T , et al. (2018)
Molecular profile Protein expression level evidence No change Western blot 3 weeks, 15 weeks Arbogast T , et al. (2018)
Molecular profile Protein expression level evidence Increased Western blot P1 Arbogast T , et al. (2018)
Molecular profile Gene expression Abnormal Rna sequencing Adult Arbogast T , et al. (2018)

M_KCTD13_5_HT_KO_MVP

Model Type: Genetic
Model Genotype: Multifactorial

Mutation:

Mice with double heterozygous for deletion of Kctd13 and Mvp. Kctd13 heterozygous mutants with deletion of exon 2 predicted to introduce a premature stop codon in exon 4 using CMV-Cre expressed ubiquitously. Mvp heterozygous mutant mice were provided by Dr. Binnaz Yalcin, PMID 28965845. Construct details of Mvp allele are not specified.

Allele Type: Knockout
Strain of Origin: C57BL/6N
Genetic Background: C57BL/6N*B6.C-Tg(CMV-cre)1Cgn/J*C57BL/6J

Es cell line: G4 ES cells
Model Source: PMID 30590535; Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Arbogast T , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Arbogast T , et al. (2018)
Motor phenotype NA Not reported NA NA Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen Decreased Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Decreased Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neurophysiology NA Not reported NA NA Arbogast T , et al. (2018)
Repetitive behavior NA Not reported NA NA Arbogast T , et al. (2018)
Seizure NA Not reported NA NA Arbogast T , et al. (2018)
Sensory NA Not reported NA NA Arbogast T , et al. (2018)
Social behavior NA Not reported NA NA Arbogast T , et al. (2018)
Communications NA Not reported NA NA Arbogast T , et al. (2018)
Developmental profile NA Not reported NA NA Arbogast T , et al. (2018)
Emotion NA Not reported NA NA Arbogast T , et al. (2018)
Immune response NA Not reported NA NA Arbogast T , et al. (2018)
Learning & memory NA Not reported NA NA Arbogast T , et al. (2018)
Maternal behavior NA Not reported NA NA Arbogast T , et al. (2018)
Molecular profile NA Not reported NA NA Arbogast T , et al. (2018)

M_KCTD13_6_HT_KO_LAT

Model Type: Genetic
Model Genotype: Multifactorial

Mutation:

Mice double heterozygous for deletion of Kctd13 and Lat. Kctd13 heterozygous mutants with deletion of exon 2 predicted to introduce a premature stop codon in exon 4 using CMV-Cre expressed ubiquitously. Lat heterozygous mutant mice were generated by deletion of exons 1-8 encoding amino acids 1-169 of the mouse LAT (PMID 10204488, Dr. Weiguo Zhang).

Allele Type: Knockout
Strain of Origin: C57BL/6N
Genetic Background: C57BL/6N*B6.C-Tg(CMV-cre)1Cgn/J*C57BL/6J

Es cell line: G4 ES cells
Model Source: PMID 30590535; Jackson Laboratory
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Arbogast T , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Arbogast T , et al. (2018)
Motor phenotype NA Not reported NA NA Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen Decreased Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology No change Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Magnetic resonance imaging (mri) Adult Arbogast T , et al. (2018)
Neurophysiology NA Not reported NA NA Arbogast T , et al. (2018)
Repetitive behavior NA Not reported NA NA Arbogast T , et al. (2018)
Seizure NA Not reported NA NA Arbogast T , et al. (2018)
Sensory NA Not reported NA NA Arbogast T , et al. (2018)
Social behavior NA Not reported NA NA Arbogast T , et al. (2018)
Communications NA Not reported NA NA Arbogast T , et al. (2018)
Developmental profile NA Not reported NA NA Arbogast T , et al. (2018)
Emotion NA Not reported NA NA Arbogast T , et al. (2018)
Immune response NA Not reported NA NA Arbogast T , et al. (2018)
Learning & memory NA Not reported NA NA Arbogast T , et al. (2018)
Maternal behavior NA Not reported NA NA Arbogast T , et al. (2018)
Molecular profile NA Not reported NA NA Arbogast T , et al. (2018)
CNVs associated with KCTD13(1 Models)
16p11.2 120 Deletion-Duplication 184  /  1584
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