Genetic Animal Models / KIRREL3

KIRREL3 Kin of Irregular Chiasm-like 3

Model Species
Mus musculus
Gene Aliases
1500010O20Rik, 2900036G11Rik, NEPH2, SST4, mKIAA1867
Reports
1
Associated Human Genes
KIRREL3
Models / Rescue Models
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Rescue Model
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Model Summary

Kirrel3 null mice display preference for a mouse over a non-social object but no significant preference for a stranger mouse over a familiar mouse. Kirrel3 null mice show impaired ultrasonic communications, including pup-to-mother calls, male-female courtship vocalisation and resident responses to intruder. Kirrel3 mice show increased locomotor activity and repetitive rearing. Kirrel3 null mice show enhanced performance on the rotarod test. Kirrel3 null mice were significantly hypersensitive to acoustic stimuli. Kirrel3 null mice show no change in anxiety-related behaviors and spatial or fear memory acquisition (Hisaoka T, et al, Sci. Rep., 2018).

Reports related to KIRREL3 (1 Reports)
# Type Title Author, Year
1 Primary Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice. Hisaoka T , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

M_KIRREL3_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Mice bearing a targeted null deletion of the entire coding region of Kirrel3 (The deleted part of the Kirrel3 gene includes the entire Kirrel3 coding region starting with the translation initiation codon in exon 1 and ending downstream of exon 16, the last exon). The targeting construct was designed to replace the Kirrel3 coding region with NLS-LacZ and the selection gene (PGK-Neo) bracketed by loxP recombination signals, which was later deleted by mating with mice expressing Cre recombinase. .

Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J

Es cell line: Not specified
Model Source: Ozgene Pty Ltd (Bentley DC, Australia)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: light phase Increased Home cage behavior Adult Hisaoka T , et al. (2018)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: dark phase No change Home cage behavior Adult Hisaoka T , et al. (2018)
Motor phenotype Self grooming: home cage/familiar environment No change Home cage behavior Adult; 1-2 months Hisaoka T , et al. (2018)
Motor phenotype Motor coordination and balance: Motor learning Increased Accelerating rotarod test: test phase (day 2) Adult Hisaoka T , et al. (2018)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test: trial phase (day 1) Adult Hisaoka T , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity Increased Open field test Adult Hisaoka T , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity Increased Light-dark exploration test: Light-dark exploration test Adult Hisaoka T , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No change Three-chamber social approach test Adult Hisaoka T , et al. (2018)
Motor phenotype General locomotor activity Increased Light-dark exploration test: Light-dark exploration test Adult Hisaoka T , et al. (2018)
Motor phenotype General locomotor activity Increased Elevated plus maze test Adult Hisaoka T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Olfactory bulb morphology No change Histology: Hematoxylin and eosin staining Adult Hisaoka T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology No change Histology: Hematoxylin and eosin staining Adult Hisaoka T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology No change Histology: Hematoxylin and eosin staining Adult Hisaoka T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Gross necroscopy Adult Hisaoka T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Gross necroscopy Adult Hisaoka T , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Histology: Hematoxylin and eosin staining Adult Hisaoka T , et al. (2018)
Neurophysiology - Not Reported - - Hisaoka T , et al. (2018)
Repetitive behavior Repetitive digging No change Home cage behavior Adult Hisaoka T , et al. (2018)
Seizure - Not Reported - - Hisaoka T , et al. (2018)
Sensory Visual placing reflex No change Visual placing test Adult Hisaoka T , et al. (2018)
Sensory Startle response: acoustic stimulus Increased Acoustic startle reflex test Adult Hisaoka T , et al. (2018)
Sensory Sensorimotor gating No change Prepulse inhibition Adult Hisaoka T , et al. (2018)
Sensory Pain or nociception Decreased Foot shock test Adult Hisaoka T , et al. (2018)
Sensory Olfaction No change Buried food test Adult Hisaoka T , et al. (2018)
Social behavior Social memory Decreased Olfactory habituation-dishabituation test Adult Hisaoka T , et al. (2018)
Social behavior Social memory Decreased Habituation-dishabituation test Adult Hisaoka T , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test Adult Hisaoka T , et al. (2018)
Social behavior Social habituation No change Habituation-dishabituation test Adult Hisaoka T , et al. (2018)
Social behavior Social dominance Decreased Resident-intruder test Adult Hisaoka T , et al. (2018)
Social behavior Social dishabituation Decreased Habituation-dishabituation test Adult Hisaoka T , et al. (2018)
Social behavior Social approach No change Three-chamber social approach test Adult Hisaoka T , et al. (2018)
Social behavior Rearing behavior Increased Open field test Adult Hisaoka T , et al. (2018)
Social behavior Aggression Decreased Resident-intruder test Adult Hisaoka T , et al. (2018)
Communications Ultrasonic vocalization: Isolation induced Increased Monitoring ultrasonic vocalizations P3, P7, 2 weeks Hisaoka T , et al. (2018)
Communications Ultrasonic vocalization: Interaction induced: opposite sex stimulus Decreased Monitoring ultrasonic vocalizations Adult Hisaoka T , et al. (2018)
Developmental profile Size/growth No change Body weight measurement 1week-4months Hisaoka T , et al. (2018)
Emotion Exploratory activity: Habituation No change Olfactory discrimination test Adult Hisaoka T , et al. (2018)
Emotion Anxiety No change Light-dark exploration test: Light-dark exploration test Adult Hisaoka T , et al. (2018)
Emotion Anxiety No change Elevated plus maze test Adult Hisaoka T , et al. (2018)
Emotion Anxiety Increased Open field test Adult Hisaoka T , et al. (2018)
Homeostasis - Not Reported - - Hisaoka T , et al. (2018)
Immune response - Not Reported - - Hisaoka T , et al. (2018)
Learning & memory Spatial working memory No change Morris water maze test Adult Hisaoka T , et al. (2018)
Learning & memory Olfactory learning and memory No change Olfactory habituation-dishabituation test Adult Hisaoka T , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Passive avoidance No change Passive avoidance test: short term Adult Hisaoka T , et al. (2018)
Learning & memory Cognitive flexibility No change Morris water maze test Adult Hisaoka T , et al. (2018)
Maternal behavior - Not Reported - - Hisaoka T , et al. (2018)
Molecular profile Targeted expression Decreased Western blot Adult Hisaoka T , et al. (2018)
CNVs associated with KIRREL3(1 Models)
11q24.2 13 Deletion-Duplication 25  /  45
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