KIRREL3 Kin of Irregular Chiasm-like 3
Model Species
Mus musculusGene Aliases
1500010O20Rik, 2900036G11Rik, NEPH2, SST4, mKIAA1867Models / Rescue Models
-Rescue Model
-Model Summary
Kirrel3 null mice display preference for a mouse over a non-social object but no significant preference for a stranger mouse over a familiar mouse. Kirrel3 null mice show impaired ultrasonic communications, including pup-to-mother calls, male-female courtship vocalisation and resident responses to intruder. Kirrel3 mice show increased locomotor activity and repetitive rearing. Kirrel3 null mice show enhanced performance on the rotarod test. Kirrel3 null mice were significantly hypersensitive to acoustic stimuli. Kirrel3 null mice show no change in anxiety-related behaviors and spatial or fear memory acquisition (Hisaoka T, et al, Sci. Rep., 2018).
External Links
Reports related to KIRREL3 (1 Reports)
| # | Type | Title | Author, Year |
|---|---|---|---|
| 1 | Primary | Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice. | Hisaoka T , et al. (2018) |
Show all Construct Details
Show all Phenotypic Profiles
M_KIRREL3_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mice bearing a targeted null deletion of the entire coding region of Kirrel3 (The deleted part of the Kirrel3 gene includes the entire Kirrel3 coding region starting with the translation initiation codon in exon 1 and ending downstream of exon 16, the last exon). The targeting construct was designed to replace the Kirrel3 coding region with NLS-LacZ and the selection gene (PGK-Neo) bracketed by loxP recombination signals, which was later deleted by mating with mice expressing Cre recombinase. .
Allele Type: Knockout
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J
Es cell line: Not specified
Model Source: Ozgene Pty Ltd (Bentley DC, Australia)
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | Locomotor activity in diurnal cycle: light phase | Increased | Home cage behavior | Adult | Hisaoka T , et al. (2018) |
| Circadian sleep/wake cycle | Adaptation to dark phase | No change | Home cage behavior | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | Self grooming: home cage/familiar environment | No change | Home cage behavior | Adult; 1-2 months | Hisaoka T , et al. (2018) |
| Motor phenotype | Motor learning | Increased | Accelerating rotarod test | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | Increased | Light-dark exploration test | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Three-chamber social approach test | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | General locomotor activity | Increased | Light-dark exploration test | Adult | Hisaoka T , et al. (2018) |
| Motor phenotype | General locomotor activity | Increased | Elevated plus maze test | Adult | Hisaoka T , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Olfactory bulb morphology | No change | Histology | Adult | Hisaoka T , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | No change | Histology | Adult | Hisaoka T , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | Adult | Hisaoka T , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Gross necroscopy | Adult | Hisaoka T , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Histology | Adult | Hisaoka T , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Gross necroscopy | Adult | Hisaoka T , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Hisaoka T , et al. (2018) |
| Repetitive behavior | Repetitive digging | No change | Home cage behavior | Adult | Hisaoka T , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Hisaoka T , et al. (2018) |
| Sensory | Visual placing reflex | No change | Visual placing test | Adult | Hisaoka T , et al. (2018) |
| Sensory | Startle response: acoustic stimulus | Increased | Acoustic startle reflex test | Adult | Hisaoka T , et al. (2018) |
| Sensory | Sensorimotor gating | No change | Prepulse inhibition | Adult | Hisaoka T , et al. (2018) |
| Sensory | Pain or nociception | Decreased | Foot shock test | Adult | Hisaoka T , et al. (2018) |
| Sensory | Olfaction | No change | Buried food test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social memory | Decreased | Olfactory habituation-dishabituation test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social memory | Decreased | Habituation-dishabituation test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social habituation | No change | Habituation-dishabituation test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social dominance | Decreased | Resident-intruder test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social dishabituation | Decreased | Habituation-dishabituation test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Social approach | No change | Three-chamber social approach test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Rearing behavior | Increased | Open field test | Adult | Hisaoka T , et al. (2018) |
| Social behavior | Aggression | Decreased | Resident-intruder test | Adult | Hisaoka T , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Hisaoka T , et al. (2018) |
| Communications | Ultrasonic vocalization: isolation induced | Increased | Monitoring ultrasonic vocalizations | P3, p7, 2 weeks | Hisaoka T , et al. (2018) |
| Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | Decreased | Monitoring ultrasonic vocalizations | Adult | Hisaoka T , et al. (2018) |
| Developmental profile | Size/growth | No change | Body weight measurement | 1week-4months | Hisaoka T , et al. (2018) |
| Emotion | Exploratory activity: habituation | No change | Olfactory discrimination test | Adult | Hisaoka T , et al. (2018) |
| Emotion | Anxiety | No change | Light-dark exploration test | Adult | Hisaoka T , et al. (2018) |
| Emotion | Anxiety | No change | Elevated plus maze test | Adult | Hisaoka T , et al. (2018) |
| Emotion | Anxiety | Increased | Open field test | Adult | Hisaoka T , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Hisaoka T , et al. (2018) |
| Learning & memory | Spatial working memory | No change | Morris water maze test | Adult | Hisaoka T , et al. (2018) |
| Learning & memory | Olfactory learning and memory | No change | Olfactory habituation-dishabituation test | Adult | Hisaoka T , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: passive avoidance | No change | Passive avoidance test | Adult | Hisaoka T , et al. (2018) |
| Learning & memory | Cognitive flexibility | No change | Morris water maze test | Adult | Hisaoka T , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Hisaoka T , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Western blot | Adult | Hisaoka T , et al. (2018) |
CNVs associated with KIRREL3(1 Models)
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| 11q24.2 | 13 | Deletion-Duplication | 25 / 45 |