Genetic Animal Models / MIR137

MIR137 microRNA 137

Model Species
Mus musculus
Gene Aliases
Mirn137, mir-137, mmu-mir-137
Reports
1
Associated Human Genes
MIR137
Models / Rescue Models
6 / 2
Rescue Model
-
Model Summary

Mice with homozygous germline KO of miR-137 or neural selective CKO show postnatal lethality with decrease in body and brain size, while heterozygotes show deficits in synaptic plasticity and learning, repetitive behavior, impaired social interaction, and elevated PDE10a. Treatment with Pde10a or KD of Pde10a rescues deficits in mir137 HT mice.

Reports related to MIR137 (1 Reports)
# Type Title Author, Year
1 Primary Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Cheng Y , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

M_MIR137_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Mir137 gene was disrupted via homologous recombination in ES cells, where two loxP sites were inserted -2kb unstream and -0.6kb downstream of the Mir137 gene. Conditional ready mice were crossed with Zp3-Cre mic to delete Mir137 in the germline.

Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Cheng Y , et al. (2018)
Motor phenotype - Not Reported - - Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry: PSD-95, synaptophysin P18, 8 weeks Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Measurement of tissue weight P16 Cheng Y , et al. (2018)
Neurophysiology - Not Reported - - Cheng Y , et al. (2018)
Repetitive behavior - Not Reported - - Cheng Y , et al. (2018)
Seizure - Not Reported - - Cheng Y , et al. (2018)
Sensory - Not Reported - - Cheng Y , et al. (2018)
Social behavior - Not Reported - - Cheng Y , et al. (2018)
Communications - Not Reported - - Cheng Y , et al. (2018)
Developmental profile Size/growth No Change Gross necroscopy P0 Cheng Y , et al. (2018)
Developmental profile Size/growth Decreased Body weight measurement P16 Cheng Y , et al. (2018)
Developmental profile Respiratory system development Decreased Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Respiratory system development No Change Histology P14 Cheng Y , et al. (2018)
Developmental profile Renal morphology Decreased Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Renal morphology No Change Histology P14 Cheng Y , et al. (2018)
Developmental profile Mortality/lethality Decreased Kaplan-Meier survival curve P0-3.4 months Cheng Y , et al. (2018)
Developmental profile Digestive system development Decreased Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Digestive system development No Change Histology P14 Cheng Y , et al. (2018)
Developmental profile Cardiovascular development and function Decreased Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Cardiovascular development and function No Change Histology P14 Cheng Y , et al. (2018)
Emotion - Not Reported - - Cheng Y , et al. (2018)
Homeostasis - Not Reported - - Cheng Y , et al. (2018)
Immune response - Not Reported - - Cheng Y , et al. (2018)
Learning & memory - Not Reported - - Cheng Y , et al. (2018)
Maternal behavior - Not Reported - - Cheng Y , et al. (2018)
Molecular profile Targeted expression Decreased Polymerase chain reaction (PCR) E15.5, P0, P14 Cheng Y , et al. (2018)
Molecular profile Protein expression level evidence No Change Western blot P12 Cheng Y , et al. (2018)
Molecular profile Protein expression level evidence Increased Western blot P12 Cheng Y , et al. (2018)
Molecular profile Gene expression No Change Polymerase chain reaction (PCR) E15.5, P0, P14 Cheng Y , et al. (2018)
Molecular profile Gene expression Abnormal Tandem mass tagging (TMT) P12 Cheng Y , et al. (2018)

M_MIR137_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Mir137 gene was disrupted via homologous recombination in ES cells, where two loxP sites were inserted -2kb unstream and -0.6kb downstream of the Mir137 gene. Conditional ready mice were crossed with Zp3-Cre mic to delete Mir137 in the germline.

Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Cheng Y , et al. (2018)
Motor phenotype Swimming ability No Change Morris water maze test 2-3 months Cheng Y , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Change Barnes maze test 2-3 months Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry: PSD-95, synaptophysin P18, 8 weeks Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No Change Measurement of tissue weight P16 Cheng Y , et al. (2018)
Neurophysiology - Not Reported - - Cheng Y , et al. (2018)
Repetitive behavior - Not Reported - - Cheng Y , et al. (2018)
Seizure - Not Reported - - Cheng Y , et al. (2018)
Sensory - Not Reported - - Cheng Y , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Social behavior Social memory Decreased Social recognition test 2-3 months Cheng Y , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Communications - Not Reported - - Cheng Y , et al. (2018)
Developmental profile Size/growth No Change Body weight measurement P16 Cheng Y , et al. (2018)
Developmental profile Respiratory system development No Change Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Respiratory system development No Change Histology P14 Cheng Y , et al. (2018)
Developmental profile Renal morphology No Change Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Renal morphology No Change Histology P14 Cheng Y , et al. (2018)
Developmental profile Mortality/lethality Increased Kaplan-Meier survival curve P0-3.4 months Cheng Y , et al. (2018)
Developmental profile Digestive system development No Change Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Digestive system development No Change Histology P14 Cheng Y , et al. (2018)
Developmental profile Cardiovascular development and function No Change Gross necroscopy P14 Cheng Y , et al. (2018)
Developmental profile Cardiovascular development and function No Change Histology P14 Cheng Y , et al. (2018)
Emotion - Not Reported - - Cheng Y , et al. (2018)
Homeostasis - Not Reported - - Cheng Y , et al. (2018)
Immune response - Not Reported - - Cheng Y , et al. (2018)
Learning & memory Spatial working memory Decreased Morris water maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial working memory Decreased Barnes maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial reference memory Decreased Barnes maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial reference memory Decreased Morris water maze test 2-3 months Cheng Y , et al. (2018)
Maternal behavior - Not Reported - - Cheng Y , et al. (2018)
Molecular profile Targeted expression Decreased Polymerase chain reaction (PCR) E15.5, P0, P14 Cheng Y , et al. (2018)
Molecular profile Protein phosphorylation Decreased Western blot P12 Cheng Y , et al. (2018)
Molecular profile Protein expression level evidence No Change Western blot P12 Cheng Y , et al. (2018)
Molecular profile Protein expression level evidence Increased Western blot P12 Cheng Y , et al. (2018)

M_MIR137_3_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Mir137 gene was disrupted via homologous recombination in ES cells, where two loxP sites were inserted -2kb unstream and -0.6kb downstream of the Mir137 gene. Conditional ready mice were crossed with Nestin-Cre mic to delete Mir137 in the neuronal lineage of the CNS and PNS.

Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Cheng Y , et al. (2018)
Motor phenotype - Not Reported - - Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry: PSD-95, synaptophysin P18 Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Western blot P18 Cheng Y , et al. (2018)
Neurophysiology - Not Reported - - Cheng Y , et al. (2018)
Repetitive behavior - Not Reported - - Cheng Y , et al. (2018)
Seizure - Not Reported - - Cheng Y , et al. (2018)
Sensory - Not Reported - - Cheng Y , et al. (2018)
Social behavior - Not Reported - - Cheng Y , et al. (2018)
Communications - Not Reported - - Cheng Y , et al. (2018)
Developmental profile Mortality/lethality Increased Kaplan-Meier survival curve P0-3.4 months Cheng Y , et al. (2018)
Developmental profile General characteristics No Change Gross necroscopy E15.5 Cheng Y , et al. (2018)
Emotion - Not Reported - - Cheng Y , et al. (2018)
Homeostasis - Not Reported - - Cheng Y , et al. (2018)
Immune response - Not Reported - - Cheng Y , et al. (2018)
Learning & memory - Not Reported - - Cheng Y , et al. (2018)
Maternal behavior - Not Reported - - Cheng Y , et al. (2018)
Molecular profile Targeted expression Decreased Quantitative PCR (qRT-PCR) E15.5, P0, P14 Cheng Y , et al. (2018)

M_MIR137_4_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Mir137 gene was disrupted via homologous recombination in ES cells, where two loxP sites were inserted -2kb unstream and -0.6kb downstream of the Mir137 gene. Conditional ready mice were crossed with Nestin-Cre mic to delete Mir137 in the neuronal lineage of the CNS and PNS.

Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Cheng Y , et al. (2018)
Motor phenotype Swimming ability No Change Morris water maze test 2-3 months Cheng Y , et al. (2018)
Motor phenotype Self grooming: artificial stress evoked Increased Reciprocal social interaction test 2-3 months Cheng Y , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Change Barnes maze test 2-3 months Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry: PSD-95, synaptophysin P18 Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Western blot P18 Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Golgi-Cox staining 2 weeks Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Increased Golgi-Cox staining 2 weeks Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Increased Golgi-Cox staining 2 weeks Cheng Y , et al. (2018)
Neurophysiology Synaptic transmission Decreased Whole-cell patch clamp 2-3 months Cheng Y , et al. (2018)
Neurophysiology Synaptic plasticity: hippocampal LTP Decreased Field potential recordings 2-3 months Cheng Y , et al. (2018)
Neurophysiology Presynaptic function: paired-pulse facilitation Decreased Paired-pulse facilitation 2-3 months Cheng Y , et al. (2018)
Neurophysiology Apoptosis: brain cells No Change Immunohistochemistry P0, P18, 2 months Cheng Y , et al. (2018)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 2-3 months Cheng Y , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 2-3 months Cheng Y , et al. (2018)
Seizure - Not Reported - - Cheng Y , et al. (2018)
Sensory - Not Reported - - Cheng Y , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Social behavior Social memory Decreased Social recognition test 2-3 months Cheng Y , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 2-3 months Cheng Y , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Communications - Not Reported - - Cheng Y , et al. (2018)
Developmental profile Mortality/lethality No Change Kaplan-Meier survival curve P0-3.4 months Cheng Y , et al. (2018)
Developmental profile General characteristics No Change Gross necroscopy E15.5 Cheng Y , et al. (2018)
Emotion Anxiety Increased Open field test 2-3 months Cheng Y , et al. (2018)
Homeostasis - Not Reported - - Cheng Y , et al. (2018)
Immune response - Not Reported - - Cheng Y , et al. (2018)
Learning & memory Spatial working memory Decreased Morris water maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial working memory Decreased Barnes maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial reference memory Decreased Barnes maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial reference memory Decreased Morris water maze test 2-3 months Cheng Y , et al. (2018)
Maternal behavior - Not Reported - - Cheng Y , et al. (2018)
Molecular profile Targeted expression Decreased Quantitative PCR (qRT-PCR) E15.5, P0, P14 Cheng Y , et al. (2018)
Molecular profile Protein phosphorylation Decreased Western blot P12 Cheng Y , et al. (2018)
Molecular profile Protein expression level evidence Increased Western blot P12 Cheng Y , et al. (2018)

M_MIR137_4_CKO_HT_Papaverine

Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous

Mutation:

Pde10a-specific inhibitor, papaverine, 30 mg/kg, dissolved in an aqueous solution of 2% Tween 80 and 0.5% hydroxyethyl cellulosewas was injected intraperitoneally on test mornings into M_MIR137_4_CKO_HT mice.

Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Cheng Y , et al. (2018)
Motor phenotype Swimming ability No Adverse Effect Morris water maze test 2-3 months Cheng Y , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Adverse Effect Barnes maze test 2-3 months Cheng Y , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Adverse Effect Open field test 2-3 months Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Cheng Y , et al. (2018)
Neurophysiology Synaptic plasticity: hippocampal LTP Ameliorated Field potential recordings 2-3 months Cheng Y , et al. (2018)
Neurophysiology Presynaptic function: paired-pulse facilitation Ameliorated Paired-pulse facilitation 2-3 months Cheng Y , et al. (2018)
Repetitive behavior Self grooming: perseveration Ameliorated Grooming behavior assessments 2-3 months Cheng Y , et al. (2018)
Repetitive behavior Repetitive digging Restored Marble-burying test 2-3 months Cheng Y , et al. (2018)
Seizure - Not Reported - - Cheng Y , et al. (2018)
Sensory - Not Reported - - Cheng Y , et al. (2018)
Social behavior Social memory Ameliorated Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Social behavior Social approach Ameliorated Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Communications - Not Reported - - Cheng Y , et al. (2018)
Developmental profile - Not Reported - - Cheng Y , et al. (2018)
Emotion Anxiety Refractory Open field test 2-3 months Cheng Y , et al. (2018)
Homeostasis - Not Reported - - Cheng Y , et al. (2018)
Immune response - Not Reported - - Cheng Y , et al. (2018)
Learning & memory Spatial working memory Ameliorated Morris water maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial working memory Ameliorated Barnes maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial reference memory Ameliorated Morris water maze test 2-3 months Cheng Y , et al. (2018)
Maternal behavior - Not Reported - - Cheng Y , et al. (2018)
Molecular profile Protein phosphorylation Restored Western blot P12 Cheng Y , et al. (2018)
Molecular profile Protein expression level evidence Restored Western blot P12 Cheng Y , et al. (2018)

M_MIR137_4_CKO_HT_Pde10a-knockdown

Model Type: RESCUE-Genetic
Model Genotype: Heterozygous

Mutation:

Pde10a was knocked down in M_MIR137_4_CKO_HT mice using lentiviruses encoding shRNA targeting Pde10a.

Allele Type: Conditional knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Cheng Y , et al. (2018)
Motor phenotype Swimming ability No Adverse Effect Morris water maze test 2-3 months Cheng Y , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Adverse Effect Open field test 2-3 months Cheng Y , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Cheng Y , et al. (2018)
Neurophysiology - Not Reported - - Cheng Y , et al. (2018)
Repetitive behavior Self grooming: perseveration Refractory Grooming behavior assessments 2-3 months Cheng Y , et al. (2018)
Repetitive behavior Repetitive digging Restored Marble-burying test 2-3 months Cheng Y , et al. (2018)
Seizure - Not Reported - - Cheng Y , et al. (2018)
Sensory - Not Reported - - Cheng Y , et al. (2018)
Social behavior Social memory Ameliorated Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Social behavior Social approach Ameliorated Three-chamber social approach test 2-3 months Cheng Y , et al. (2018)
Communications - Not Reported - - Cheng Y , et al. (2018)
Developmental profile - Not Reported - - Cheng Y , et al. (2018)
Emotion Anxiety Restored Open field test 2-3 months Cheng Y , et al. (2018)
Homeostasis - Not Reported - - Cheng Y , et al. (2018)
Immune response - Not Reported - - Cheng Y , et al. (2018)
Learning & memory Spatial working memory Ameliorated Morris water maze test 2-3 months Cheng Y , et al. (2018)
Learning & memory Spatial reference memory Ameliorated Morris water maze test 2-3 months Cheng Y , et al. (2018)
Maternal behavior - Not Reported - - Cheng Y , et al. (2018)
Molecular profile - Not Reported - - Cheng Y , et al. (2018)
Other MIR137 Rescue Models(2 Models)
M_MIR137_4_CKO_HT 1 Genetic Pharmaceutical Papaverine
M_MIR137_4_CKO_HT 1 Genetic Genetic Ablation of Pde10a
CNVs associated with MIR137(1 Models)
1p21.3 13 Deletion-Duplication 24  /  54
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