NLGN3 neuroligin 3
Model Species
Mus musculusGene Aliases
A230085M13Rik, HNL3, NL3Models / Rescue Models
50 / 10Rescue Model
-Model Summary
Mutant mice display impaired social interactions; increase in inhibitory synaptic transmission.
External Links
Reports related to NLGN3 (23 Reports)
# | Type | Title | Author, Year |
---|---|---|---|
1 | Primary | A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. | Tabuchi K , et al. (2007) |
2 | Additional | Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit. | Radyushkin K , et al. (2009) |
3 | Additional | Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice. | Chadman KK , et al. (2009) |
4 | Additional | Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. | Etherton M , et al. (2011) |
5 | Additional | Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism. | Baudouin SJ , et al. (2012) |
6 | Additional | Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism. | Pizzarelli R and Cherubini E (2013) |
7 | Additional | Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors. | Rothwell PE , et al. (2014) |
8 | Additional | Enhanced synapse remodelling as a common phenotype in mouse models of autism. | Isshiki M , et al. (2014) |
9 | Additional | Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. | Zhang B , et al. (2015) |
10 | Additional | Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders. | Liu JJ , et al. (2017) |
11 | Additional | Male and Female Mice Lacking Neuroligin-3 Modify the Behavior of Their Wild-Type Littermates. | Kalbassi S , et al. (2017) |
12 | Additional | The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in ... | Martella G , et al. (2017) |
13 | Additional | Genetic background effects in Neuroligin-3 mutant mice: Minimal behavioral abnormalities on C57 background. | Jaramillo TC , et al. (2017) |
14 | Additional | Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice. | Cao W , et al. (2018) |
15 | Additional | Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction. | Bariselli S , et al. (2018) |
16 | Additional | UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism. | Trobiani L , et al. (2018) |
17 | Additional | Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors. | Lee Y , et al. (2019) |
18 | Additional | Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3. | Hosie S , et al. (2019) |
19 | Additional | Rescue of oxytocin response and social behaviour in a mouse model of autism | Hanna Hörnberg (2020) |
20 | Additional | An altered glial phenotype in the NL3 R451C mouse model of autism | Matta SM et al. (2020) |
21 | Additional | Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2 | Horner AE et al. (2021) |
22 | Additional | Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice | Yoshida T et al. (2021) |
23 | Additional | - | Lee CYQ et al. (2023) |
M_NLGN3_10_CKO_HM
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Conditional deletion of exons 2 - 3 of Nlgn3 using D1-cre, in neurons expressing dopamine receptor Drd1a, authors specifically looked at D1a expressing medium spiny neurons in the striatum
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_10_CKO_HM_REINSTATE-NLGN3
Model Type: RESCUE-Genetic
Model Genotype: Hemizygous
Mutation:
Reinstatement of Nlgn3 specifically in Drd1a (D1) expressing neurons of the nucleus accumbens using an AAV that contains Nlgn3 and mVenus-expression cassettes orientated as a double-inverse open reading frame (DIO) . Injection of this AAV into the NAc of Nlgn3 CKO mice carrying D1-Cre restores Nlgn3 function only in D1 expressing neurons at the site of injection
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | Restored | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Restored | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_11_CKO_HM
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Conditional deletion of exons 2 - 3 of Nlgn3 using A2a-cre, in medium spiny neurons of striatal indirect pathway (striatopallidal) expressing adenosine-2a receptor, that are also known to express dopamine receptor 2 (Drd2)
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | No change | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_12_KI_R451C_D1-CRE
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exon 7 carrying coding mutation (R451C) replaced the wild type exon 7 using a neo cassette as a selectable marker and flanked by loxP sites, D1-Cre transgene.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_13_CKO_HM_DS
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Conditional deletion of exons 2 - 3 of Nlgn3 using AAV-Cre transgene under the synapsin promoter, injected into the dorsal striatum in 4 week old mice
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | No change | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_14_CKO_HM_NAC
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Conditional deletion of exons 2 - 3 of Nlgn3 using AAV-Cre transgene under the synapsin promoter, injected into the nucleus accumbens in 4 week old mice
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_16_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mutant mice carrying a Neo-STOP-tetO cassette inserted after the transcriptional start site of Nlgn3 which results in a complete loss of NL3 expression. Doxycycline (100microg/ml) was added to the drinking water during breeding and after weaning of pups.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Motor phenotype | General locomotor activity | No change | Open field test | 4 weeks | Hanna Hörnberg (2020) |
Motor phenotype | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Motor phenotype | Motor coordination and balance | Decreased | Erasmus ladder test | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Immunohistochemistry | Adult | Hanna Hörnberg (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: Vasopressin | No change | Targeted parallel reaction monitoring assay (PRM LC-MS) | Adult | Hanna Hörnberg (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: Vasopressin | No change | Fluorescence in situ hybridization (FISH) | Adult | Hanna Hörnberg (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: OXT | No change | Targeted parallel reaction monitoring assay (PRM LC-MS) | Adult | Hanna Hörnberg (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: Oxytocin expressing | No change | Immunohistochemistry | Adult | Hanna Hörnberg (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | No change | Immunohistochemistry | Adult | Hanna Hörnberg (2020) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | No change | Immunohistochemistry | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | No change | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Increased | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Increased | Quantitative pcr (qrt-pcr) | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number | No change | Whole-cell patch clamp | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Abnormal | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Neurophysiology | Membrane potential | No change | Whole-cell current clamp | P27-35 | Hanna Hörnberg (2020) |
Neurophysiology | Intrinsic membrane properties | No change | Whole-cell current clamp | P27-35 | Hanna Hörnberg (2020) |
Neurophysiology | Hyperpolarization activated cation currents | No change | Whole-cell patch clamp | P27-35 | Hanna Hörnberg (2020) |
Neurophysiology | Action potential property: firing rate | Decreased | Whole-cell current clamp | P27-35 | Hanna Hörnberg (2020) |
Neurophysiology | Synaptic plasticity: cerebellar ltd | No change | Whole-cell patch clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | Synaptic plasticity: cerebellar ltd | Decreased | Whole-cell patch clamp | 2-3 months | Baudouin SJ , et al. (2012) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Paired-pulse ratio | 2-3 months | Baudouin SJ , et al. (2012) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Increased | Whole-cell patch clamp | 2-3 months | Baudouin SJ , et al. (2012) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Decreased | Whole-cell patch clamp | 3-4 weeks | Baudouin SJ , et al. (2012) |
Neurophysiology | Decay kinetics of miniature post synaptic currents | No change | Whole-cell patch clamp | 2-3 months | Baudouin SJ , et al. (2012) |
Repetitive behavior | Repetitive digging | Decreased | Marble-burying test | 4 weeks | Hanna Hörnberg (2020) |
Repetitive behavior | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Repetitive behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Seizure | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Sensory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Social behavior | Social memory | Decreased | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Social behavior | Social memory | Decreased | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Social behavior | Social interaction | Decreased | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Social behavior | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Social behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Physiological parameters | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Communications | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Communications | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Developmental profile | Size/growth | No change | Marble-burying test | 4 weeks | Hanna Hörnberg (2020) |
Developmental profile | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Developmental profile | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Emotion | Exploratory activity: Habituation | No change | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Emotion | Anxiety | No change | Open field test | 4 weeks | Hanna Hörnberg (2020) |
Emotion | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Emotion | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Immune response | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Learning & memory | Object recognition memory | No change | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Learning & memory | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Learning & memory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Maternal behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Molecular profile | Regulation of translation | Abnormal | Immunohistochemistry | 4 weeks | Hanna Hörnberg (2020) |
Molecular profile | Regulation of translation | Abnormal | Tandem mass tagging (TMT) | 4 weeks | Hanna Hörnberg (2020) |
Molecular profile | Proteomic profile diversity | Abnormal | Shotgun sequencing | Adult | Hanna Hörnberg (2020) |
Molecular profile | Protein expression level evidence | No change | Western blot | 4 weeks | Hanna Hörnberg (2020) |
Molecular profile | Gene expression | Increased | Fluorescence in situ hybridization (FISH) | Adult | Hanna Hörnberg (2020) |
Molecular profile | Targeted expression | Decreased | Western blot | Unreported | Zhang B , et al. (2015) |
Molecular profile | Protein expression level evidence | No change | Western blot | Unreported | Zhang B , et al. (2015) |
Molecular profile | Targeted expression | Decreased | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Decreased | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein localization: synapse | Decreased | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 2-3 months | Baudouin SJ , et al. (2012) |
M_NLGN3_16_KO_HM_ETC-168-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Mutant mice were treated with vehicle or 5 mg/kg etc-168 for 7 consecutive days between p21 and p28.
Allele Type: Knockout
Strain of Origin: 129S6/SvEvTac
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | General locomotor activity | No adverse effect | Open field test | 4 weeks | Hanna Hörnberg (2020) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | 4 weeks | Hanna Hörnberg (2020) |
Social behavior | Social memory | Restored | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Social behavior | Social memory | Restored | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Social behavior | Social interaction | Restored | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Developmental profile | Size/growth | No adverse effect | Marble-burying test | 4 weeks | Hanna Hörnberg (2020) |
Emotion | Exploratory activity: Habituation | No adverse effect | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Emotion | Anxiety | No adverse effect | Open field test | 4 weeks | Hanna Hörnberg (2020) |
Learning & memory | Object recognition memory | No adverse effect | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
Molecular profile | Regulation of translation | Restored | Immunohistochemistry | 4 weeks | Hanna Hörnberg (2020) |
Molecular profile | Regulation of translation | Restored | Tandem mass tagging (TMT) | 4 weeks | Hanna Hörnberg (2020) |
M_NLGN3_16_KO_HM_ETC-168-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Mutant mice were administered short-term oral treatment two applications of 5 mg/kg etc-168 over 26 h
Allele Type: Knockout
Strain of Origin: 129S6/SvEvTac
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neurophysiology | Action potential property: firing rate | Restored | Whole-cell current clamp | P27-35 | Hanna Hörnberg (2020) |
Social behavior | Social memory | Restored | Habituation-dishabituation test | 4 weeks | Hanna Hörnberg (2020) |
M_NLGN3_16_KO_HM_REINSTATE-PURKINJEN
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Mutant mice where the knockout allele with a Neo-STOP-tetO cassette inserted after the transcriptional start site of Nlgn3 is selectively reexpressed in Purkinje cells (PCs) under the control of the tetracycline transactivator (Pcp2-tTA).
Allele Type: Conditional LOF knockin
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Motor phenotype | Motor coordination and balance | Restored | Erasmus ladder test | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Quantitative pcr (qrt-pcr) | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | No adverse effect | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Restored | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Communications | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3-4 weeks | Baudouin SJ , et al. (2012) |
Molecular profile | Protein localization: synapse | Restored | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein expression level evidence | No adverse effect | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein expression level evidence | No adverse effect | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
M_NLGN3_16_KO_HM_REINSTATE-PURKINJEN-ADULT
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Mutant mice where the knockout allele with a Neo-STOP-tetO cassette inserted after the transcriptional start site of Nlgn3 is selectively reexpressed in Purkinje cells (PCs) under the control of the tetracycline transactivator (Pcp2-tTA). Nlgn3-PC mice were raised in the presence of doxycycline [transactivator inactive, NL3 expression off]. Doxycycline (100microg/ml) was added to the drinking water during breeding and after weaning of pups. Subsequently, doxyclycine was removed at P30 to allow reexpression of Nlgn3. Mice were sacrificed at P60 for experimentation.
Allele Type: Conditional LOF knockin
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Motor phenotype | Motor coordination and balance | Restored | Erasmus ladder test | 6 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Western blot | 6 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Quantitative pcr (qrt-pcr) | 6 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Restored | Histology | 6 months | Baudouin SJ , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Communications | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Western blot | 6 months | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Histology | 6 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 6 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein localization: synapse | No adverse effect | Western blot | 6 months | Baudouin SJ , et al. (2012) |
M_NLGN3_17_KO_PURKINJE
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Mutant mice where the knockout allele with a Neo-STOP-tetO cassette inserted after the transcriptional start site of Nlgn3 is selectively reexpressed in Purkinje cells (PCs) under the control of the tetracycline transactivator (Pcp2-tTA).
Allele Type: Conditional LOF knockin
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Motor phenotype | Motor coordination and balance | Restored | Erasmus ladder test | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Quantitative pcr (qrt-pcr) | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | No adverse effect | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Restored | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Communications | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 3-4 weeks | Baudouin SJ , et al. (2012) |
Molecular profile | Protein localization: synapse | Restored | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein expression level evidence | No adverse effect | Western blot | 2-3 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein expression level evidence | No adverse effect | Histology | 2-3 months | Baudouin SJ , et al. (2012) |
M_NLGN3_17_KO_PURKINJE-ADULT
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Mutant mice where the knockout allele with a Neo-STOP-tetO cassette inserted after the transcriptional start site of Nlgn3 is selectively reexpressed in Purkinje cells (PCs) under the control of the tetracycline transactivator (Pcp2-tTA). Nlgn3-PC mice were raised in the presence of doxycycline [transactivator inactive, NL3 expression off]. Doxycycline (100microg/ml) was added to the drinking water during breeding and after weaning of pups. Subsequently, doxyclycine was removed at P30 to allow reexpression of Nlgn3. Mice were sacrificed at P60 for experimentation.
Allele Type: Conditional LOF knockin
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Motor phenotype | Motor coordination and balance | Restored | Erasmus ladder test | 6 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Western blot | 6 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | Restored | Quantitative pcr (qrt-pcr) | 6 months | Baudouin SJ , et al. (2012) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Restored | Histology | 6 months | Baudouin SJ , et al. (2012) |
Neurophysiology | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Repetitive behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Seizure | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Sensory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Social behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Physiological parameters | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Communications | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Developmental profile | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Emotion | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Immune response | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Learning & memory | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Maternal behavior | NA | Not reported | NA | NA | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Western blot | 6 months | Baudouin SJ , et al. (2012) |
Molecular profile | Targeted expression | Restored | Histology | 6 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 6 months | Baudouin SJ , et al. (2012) |
Molecular profile | Protein localization: synapse | No adverse effect | Western blot | 6 months | Baudouin SJ , et al. (2012) |
M_NLGN3_18_KD
Model Type: Genetic
Model Genotype: Wildtype
Mutation:
Seven-week-old wildtype C57BL/6 male mice were injected with Nlgn3-siRNA (1392209,NM_172932.1), bilaterally in the dorsal striatum using a stereotaxic apparatus, resulting in a reduction of Nlgn3 transcript levels to about 0.6 fold compared with control siRNA injected mice.
Allele Type: Knockdown
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
Es cell line: NA
Model Source: Daehan BioLink (Eumsung, Chungbuk, Republic of Korea)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Motor phenotype | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | Adult | Lee Y , et al. (2019) |
Repetitive behavior | Repetitive digging | Decreased | Home cage behavior | Adult | Lee Y , et al. (2019) |
Seizure | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Sensory | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Social behavior | Social memory | No change | U-field assay | Adult | Lee Y , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Communications | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Emotion | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Immune response | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Learning & memory | Object recognition memory | Decreased | Object preference test | Adult | Lee Y , et al. (2019) |
Maternal behavior | NA | Not reported | NA | NA | Lee Y , et al. (2019) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | Adult | Lee Y , et al. (2019) |
M_NLGN3_19_KO_HE
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Male Nlgn3 (y/-) mice from mixed genotype housing (MGH), that is co-housed with wild-type Nlgn3 (y/+) littermates. Control mice were Nlgn3 (y/+) mice littermates or from SGH (single genotype housing) as applicable. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | Adaptation to dark phase | No change | Home cage behavior | 2-4 month | Kalbassi S , et al. (2017) |
Motor phenotype | Spontaneous movement | No change | Spontaneous movement analysis | 2-4 month | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 3-4 weeks, 2-4 months | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | Repetitive digging | Increased | Marble-burying test | 2-4 month | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social scent marking or recognition | Increased | Olfactory discrimination test | 2-4 month | Kalbassi S , et al. (2017) |
Social behavior | Social interaction: with juveniles | Decreased | Reciprocal social interaction test | 3-4 weeks | Kalbassi S , et al. (2017) |
Social behavior | Social dominance | Decreased | Tube test of social dominance | 2-4 month | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Physiological parameters | Hormone levels | No change | Elisa | 2-4 month | Kalbassi S , et al. (2017) |
Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | Decreased | Monitoring ultrasonic vocalizations | 2-4 month | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Thigmotaxis | No change | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 3-4 weeks, 2-4 months | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 3-4 weeks, 2-4 months | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | Targeted expression | Decreased | Western blot | 2-4 month | Kalbassi S , et al. (2017) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 2-4 month | Kalbassi S , et al. (2017) |
M_NLGN3_19_KO_HE_REINSTATE-NLGN3
Model Type: RESCUE-Genetic
Model Genotype: Hemizygous
Mutation:
Male Pvalb (Cre/+); Nlgn3 (y/-) mice were generated by crossing Pvalb (+/+);Nlgn3 (+/-) dams with Pvalb (Cre/Cre);Nlgn3 (y/+) sires. Littermates with the genotype Pvalb (Cre/+); Nlgn3 (y/+) were used as controls. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789). Cre driven by endogenous Pvalb promoter reverses the stop cassette in Pvalb-expressing cells to reinstate Nlgn3 expression in those cells.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Refractory | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social scent marking or recognition | Ameliorated | Western blot | 2-4 month | Kalbassi S , et al. (2017) |
Social behavior | Social interaction: with juveniles | Restored | Reciprocal social interaction test | 3-4 weeks | Kalbassi S , et al. (2017) |
Social behavior | Social dominance | Restored | Tube test of social dominance | 2-4 month | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | Refractory | Monitoring ultrasonic vocalizations | 2-4 month | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No adverse effect | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | 2-4 month | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | Targeted expression | Restored | Western blot | 2-4 month | Kalbassi S , et al. (2017) |
Molecular profile | Targeted expression | Refractory | Western blot | 2-4 month | Kalbassi S , et al. (2017) |
M_NLGN3_1_KI_R451C
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exon 7 carrying coding mutation (R451C) replaced the wild type exon 7 using a neo cassette as a selectable marker and flanked by loxP sites.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL6J * 129S2
Es cell line: R1
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Motor phenotype | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 2-4 months | Tabuchi K , et al. (2007) |
Motor phenotype | General locomotor activity | No change | Light-dark exploration test | 2-4 months | Tabuchi K , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: enteric neurons: gabaergic | No change | Immunofluorescence staining | 8-12 weeks | Hosie S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: enteric neurons | No change | Immunofluorescence staining | 8-12 weeks | Hosie S , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: enteric neurons | Increased | Immunofluorescence staining | 8-12 weeks | Hosie S , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synaptic morphology | No change | Electron microscopy | Unreported | Etherton M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synaptic morphology | Decreased | Electron microscopy | Unreported | Etherton M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | No change | Fluorescence microscopy | Unreported | Etherton M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Increased | Sholl analysis | Unreported | Etherton M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: inhibitory | Increased | Immunohistochemistry | 3 months | Tabuchi K , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | No change | Immunohistochemistry | 3 months | Tabuchi K , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Electron microscopy | 8 weeks | Tabuchi K , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | No change | Immunohistochemistry | 3 months | Tabuchi K , et al. (2007) |
Neurophysiology | Synaptic transmission: inhibitory | Decreased | Immunofluorescence staining | 8-12 weeks | Hosie S , et al. (2019) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | Tonic currents through extrasynaptic receptors | No change | Whole-cell patch clamp | P11-p15 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Synaptic transmission: inhibitory | Abnormal | Whole-cell patch clamp | P9-p11 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | No change | Whole-cell patch clamp | P4-p9 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | No change | Whole-cell patch clamp | P4-p9 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | No change | Whole-cell patch clamp | P11-p15 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | Increased | Whole-cell patch clamp | 4-5 weeks | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Spontaneous post synaptic events | Increased | Whole-cell patch clamp | P4-p9 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Spontaneous post synaptic events | Increased | Whole-cell patch clamp | P11-p15 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Spontaneous post synaptic events | Increased | Whole-cell patch clamp | 4-5 weeks | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Neurotransporter activity | No change | Whole-cell patch clamp | P11-p16 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Neurotransmitter release | Increased | Whole-cell patch clamp | P11-p15 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Neuronal ion channel activity | No change | Whole-cell patch clamp | P11-p15 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Membrane potential | No change | Whole-cell patch clamp | P4-p9 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Intrinsic bursting events or spikes | Increased | Whole-cell patch clamp | P4-p9 | Pizzarelli R and Cherubini E (2013) |
Neurophysiology | Voltage sensitivity of n-methyl d-aspartate (nmda) receptors | No change | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic transmission: excitatory | Abnormal | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic transmission: excitatory | Increased | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic plasticity: hippocampal ltp | Increased | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | No change | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | Increased | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Spontaneous post synaptic events: inhibitory currents | No change | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Spontaneous post synaptic events: inhibitory currents | Increased | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | No change | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | Increased | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Neuronal ion channel activity | Increased | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic transmission: inhibitory | Increased | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Synaptic transmission: excitatory | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Synaptic plasticity | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Spontaneous post synaptic events: inhibitory currents | Increased | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Repetitive behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Seizure | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Sensory | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Sensory | Vision | No change | Morris water maze test | 2-4 months | Tabuchi K , et al. (2007) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | Unreported | Etherton M , et al. (2011) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | Unreported | Etherton M , et al. (2011) |
Social behavior | Social approach | No change | Three-chamber social approach test | Unreported | Etherton M , et al. (2011) |
Social behavior | Inanimate object preference | No change | Novel object recognition test | Unreported | Etherton M , et al. (2011) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 2-4 months | Tabuchi K , et al. (2007) |
Physiological parameters | Metabolic function | Abnormal | Spectrophotometry | 5-9 weeks | Hosie S , et al. (2019) |
Physiological parameters | Intestinal microbiota functional profile | Abnormal | Carbon substrate utilization assay | 5-9 weeks | Hosie S , et al. (2019) |
Physiological parameters | Intestinal microbiota composition | Abnormal | 16s rrna gene sequence analysis for identification of bacteria | 5-9 weeks | Hosie S , et al. (2019) |
Physiological parameters | Digestive system function: gastrointestinal motility: peristaltic reflexes | No change | Measurement of colonic motility | 8-12 weeks | Hosie S , et al. (2019) |
Physiological parameters | Digestive system function: gastrointestinal motility | Increased | Intestinal transit time | Adult | Hosie S , et al. (2019) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Physiological parameters | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Communications | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Communications | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Developmental profile | Tissue weight | No change | Measurement of tissue weight | 8-12 weeks | Hosie S , et al. (2019) |
Developmental profile | Size/growth | No change | Body weight measurement | 8-12 weeks | Hosie S , et al. (2019) |
Developmental profile | Digestive system development | No change | Gross necroscopy | 8-12 weeks | Hosie S , et al. (2019) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Developmental profile | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Developmental profile | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Emotion | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Emotion | Exploratory activity | No change | Novel object recognition test | 2-4 months | Tabuchi K , et al. (2007) |
Emotion | Anxiety | No change | Open field test | 2-4 months | Tabuchi K , et al. (2007) |
Emotion | Anxiety | No change | Elevated plus maze test | 2-4 months | Tabuchi K , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Immune response | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Learning & memory | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Learning & memory | Spatial learning | Increased | Morris water maze test | 2-4 months | Tabuchi K , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Pizzarelli R and Cherubini E (2013) |
Maternal behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | 8 weeks | Hosie S , et al. (2019) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | Protein expression level evidence | No change | Peak-scaled non-stationary fluctuation analysis | Unreported | Pizzarelli R and Cherubini E (2013) |
Molecular profile | Targeted expression | Decreased | Western blot | Unreported | Etherton M , et al. (2011) |
Molecular profile | Protein expression level evidence | No change | Western blot | Unreported | Etherton M , et al. (2011) |
Molecular profile | Protein expression level evidence | No change | Western blot | Unreported | Etherton M , et al. (2011) |
Molecular profile | Protein expression level evidence | Increased | Western blot | Unreported | Etherton M , et al. (2011) |
Molecular profile | Protein expression level evidence | Increased | Western blot | Unreported | Etherton M , et al. (2011) |
Molecular profile | Targeted expression | Decreased | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Protein expression level evidence | No change | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Protein expression level evidence | Increased | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Protein expression level evidence | Decreased | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 3 months | Tabuchi K , et al. (2007) |
M_NLGN3_1_KI_R451C_GEPH-GFP
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
The progenitor cells for layer 2/3 neurons in the somatosensory cortex and anterior frontal cortex of NLGN3_1_KI_R451C mice were transfected using in utero electroporation to label excitatory synapses. E15.5 timed pregnant mice were deeply anaesthetized, their uterine horns were exposed and approximately 1ul of DNA mixture, containing DsRed2 plasmid (1ug/ul) and Gephyrin-GFP plasmid (1-2ug/ul), was pressure injected into the lateral ventricle of each embryo through a micropipette. Electric pulses were passed through the head of each embryo using two tweezer type electrodes for electroporation.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * C57BL/6
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | No change | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine turnover | No change | Histology | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine turnover | Increased | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No change | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neurophysiology | Neuronal activation following behavioral stimulation: c-fos levels | No change | Immunohistochemistry | 3 weeks | Isshiki M , et al. (2014) |
Neurophysiology | Neuronal activation following behavioral stimulation: c-fos levels | Decreased | Immunohistochemistry | 3 weeks | Isshiki M , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Communications | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
M_NLGN3_1_KI_R451C_PSD95-GFP
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
The progenitor cells for layer 2/3 neurons in the somatosensory cortex and anterior frontal cortex of NLGN3_1_KI_R451C mice were transfected using in utero electroporation to label excitatory synapses. E15.5 timed pregnant mice were deeply anaesthetized, their uterine horns were exposed and approximately 1ul of DNA mixture, containing DsRed2 plasmid (1ug/ul) and PSD-95-GFP plasmid (1-2ug/ul), was pressure injected into the lateral ventricle of each embryo through a micropipette. Electric pulses were passed through the head of each embryo using two tweezer type electrodes for electroporation.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * C57BL/6
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | No change | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine turnover | No change | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine turnover | Increased | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No change | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Communications | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Isshiki M , et al. (2014) |
M_NLGN3_20_KO_HE
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Male Nlgn3 (y/-) mice from single genotype housing (SGH). Control mice were Nlgn3 (y/+) mice from SGH. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | Adaptation to dark phase | No change | Home cage behavior | 2-4 month | Kalbassi S , et al. (2017) |
Motor phenotype | Spontaneous movement | No change | Spontaneous movement analysis | 2-4 month | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 3-4 weeks, 2-4 months | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | Repetitive digging | Decreased | Marble-burying test | 2-4 month | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social scent marking or recognition | Increased | Olfactory discrimination test | 2-4 month | Kalbassi S , et al. (2017) |
Social behavior | Social interaction: with juveniles | No change | Reciprocal social interaction test | 3-4 weeks | Kalbassi S , et al. (2017) |
Social behavior | Social dominance | No change | Tube test of social dominance | 2-4 month | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Physiological parameters | Hormone levels | Increased | Elisa | 2-4 month | Kalbassi S , et al. (2017) |
Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | Decreased | Monitoring ultrasonic vocalizations | 2-4 month | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Thigmotaxis | Decreased | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 3-4 weeks | Kalbassi S , et al. (2017) |
Emotion | Anxiety | Decreased | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | Targeted expression | Decreased | Western blot | 2-4 month | Kalbassi S , et al. (2017) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 2-4 month | Kalbassi S , et al. (2017) |
M_NLGN3_21_KI_R451C
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exon 7 was replaced with an exon 7 carrying an arginine to cysteine amino acid substitution at position 451 (R451C). A neo cassette was used as a selectable marker. KI mice were crossed with G42 mice (G42: CB6-Tg(Gad1-EGFP)G42Zjh/J) to tag Gad1 positive interneurons. .
Allele Type: ASD LOF mutation
Strain of Origin: Not Specified
Genetic Background: C57BL/6J
Es cell line: Not Specified
Model Source: The Jackson Laboratory; Chadman et al., 2008 PMID 19360662
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Motor phenotype | Hyperactivity | Increased | Home cage behavior | 2-3 months | Cao W , et al. (2018) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 2-3 months | Cao W , et al. (2018) |
Motor phenotype | Swimming ability | No change | Morris water maze test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Motor phenotype | Motor learning | No change | Accelerating rotarod test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Novel cage test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Partition test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Abnormal | In vivo local field potential (lfp) recordings | 2-3 months | Cao W , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Neurophysiology | Neuronal activation | Decreased | Immunohistochemistry | 2-3 months | Cao W , et al. (2018) |
Neurophysiology | Network excitability | Abnormal | In vivo local field potential (lfp) recordings | 2-3 months | Cao W , et al. (2018) |
Neurophysiology | Intrinsic bursting events or spikes | Decreased | Whole-cell patch clamp | 2-3 months | Cao W , et al. (2018) |
Neurophysiology | Intrinsic bursting events or spikes | No change | Whole-cell patch clamp | 2-3 months | Cao W , et al. (2018) |
Neurophysiology | Electroencephalogram (eeg) signature | Decreased | Electroencephalogram (eeg) | 2-3 months | Cao W , et al. (2018) |
Neurophysiology | Action potential property: firing rate | Abnormal | In vivo local field potential (lfp) recordings | 2-3 months | Cao W , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Sensory | Startle response: acoustic stimulus | Decreased | Acoustic startle reflex test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Sensory | Olfaction | No change | Buried food test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Sensory | Olfaction | No change | Olfactory discrimination test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Social behavior | Social approach | No change | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Social behavior | Social interaction: with juveniles | No change | Three-chamber social approach test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Social behavior | Social interaction | No change | Partition test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Social behavior | Nest building behavior | Increased | Nest building assay | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Communications | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Communications | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 2-3 months | Cao W , et al. (2018) |
Emotion | Thigmotaxis | No change | Morris water maze test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Emotion | Thigmotaxis | No change | Open field test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Emotion | Exploratory activity: habituation | No change | Olfactory discrimination test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Emotion | Anxiety | No change | Light-dark exploration test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Learning & memory | Spatial working memory | No change | Y-maze test | 2-3 months | Cao W , et al. (2018) |
Learning & memory | Spatial working memory | No change | Morris water maze test | 2-3 months | Cao W , et al. (2018) |
Learning & memory | Object recognition memory | No change | Novel object recognition test | 2-3 months | Cao W , et al. (2018) |
Learning & memory | Spatial working memory | No change | Morris water maze test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Learning & memory | Spatial reference memory | Decreased | Morris water maze test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | No change | Fear conditioning test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Learning & memory | Cognitive flexibility | No change | Morris water maze test | 2.3 to 6.6 months | Jaramillo TC , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
Molecular profile | Signaling | Abnormal | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein binding | Decreased | Co-immunoprecipitation | Adult | Yoshida T et al. (2021) |
Molecular profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Molecular profile | NA | Not reported | NA | NA | Jaramillo TC , et al. (2017) |
M_NLGN3_21_KI_R451C_PVALB-ACT
Model Type: RESCUE-Genetic
Model Genotype: Hemizygous
Mutation:
Light-sensitive ion channels (channelrhodopsin-2 [ChR2] or halorhodopsin [eNpHR]) were selectively expressed in PV interneurons in the mPFC region of Pvalb-cre-crossed KI and WT mice, for optogenetic activation of PV interneurons in 8 week old males. 8-week-old mice expressing PV- ChR2 were unilaterally stimulated in the mPFC during the three-chamber test using light activation at 40 Hz nested at 8 Hz.
Allele Type: ASD LOF mutation
Strain of Origin: Not Specified
Genetic Background: C57BL/6J
Es cell line: Not Specified
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Motor phenotype | General locomotor activity: ambulatory activity | Refractory | Open field test | 2-3 months | Cao W , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Neurophysiology | Network excitability | Restored | In vivo local field potential (lfp) recordings | 2-3 months | Cao W , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Social behavior | Social memory | Restored | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Communications | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Emotion | Anxiety | No adverse effect | Open field test | 2-3 months | Cao W , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Molecular profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
M_NLGN3_21_KI_R451C_REINSTATE-NLGN3
Model Type: RESCUE-Genetic
Model Genotype: Hemizygous
Mutation:
For NL3 re-expression of 8-week-old male WT and KI mice, adeno-associated virus (AAV) 2/9 serotype (pAAV-CMV-Nlgn3-2A-mCherry-3FLAG or pAAV-CMV-2A-mCherry-3FLAG) was injected (500 nL/hemisphere). .
Allele Type: ASD LOF mutation
Strain of Origin: Not Specified
Genetic Background: C57BL/6J
Es cell line: Not Specified
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Social behavior | Social memory | Restored | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Social behavior | Social approach | No adverse effect | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Communications | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Molecular profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
M_NLGN3_22_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Female Nlgn3 (-/-) mice in single genotype housing (SGH) were generated by crossing Nlgn3 (-/-) dams with Nlgn3 (y/-) sires. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social interaction | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Communications | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 3-4 weeks | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
M_NLGN3_23_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Female Nlgn3 (-/-) mice housed with heterozygous female littermates (H-KO) were generated by crossing Nlgn3 (+/-) dams with Nlgn3 (y/-) sires. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social interaction | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 2-4 month | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Communications | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Thigmotaxis | Decreased | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 3-4 weeks | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 3-4 weeks | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 2-4 month | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
M_NLGN3_24_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Female Nlgn3 (+/-) mice housed with null female littermates (H-KO) were generated by crossing Nlgn3 (+/-) dams with Nlgn3 (y/-) sires. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 2-4 month | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Communications | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Thigmotaxis | No change | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 2-4 month | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
M_NLGN3_25_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Female Nlgn3 (+/-) mice housed with wildtype female littermates (H-WT) were generated by crossing Nlgn3 (+/-) dams with Nlgn3 (y/+) sires. Nlgn3 null allele contains a stop cassette flanked by loxP sites in the promoter region and lack Nlgn3 expression (Tanaka KF, et al., 2010; PMID 20163789).
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Neurophysiology | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | 2-4 month | Kalbassi S , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Communications | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Emotion | Thigmotaxis | No change | Open field test | 2-4 month | Kalbassi S , et al. (2017) |
Emotion | Anxiety | No change | Elevated plus maze test | 2-4 month | Kalbassi S , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Kalbassi S , et al. (2017) |
M_NLGN3_26_KI_R451C
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Mice harbor the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: B6*129
Es cell line: Not Specified
Model Source: Sudhof laboratory (PMID 17823315 )
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neurophysiology | Synaptic plasticity: striatal ltd | Decreased | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Membrane potential | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Intrinsic membrane properties | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Action potential property: half-width | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Action potential property: firing pattern | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Action potential property: amplitude | No change | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Communications | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
M_NLGN3_26_KI_R451C_ACEA
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Mice harboring the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7 were treated with the highly selective CB1 receptor agonist ACEA (20 microM).
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: B6*129
Es cell line: Not Specified
Model Source: Sudhof laboratory (PMID 17823315 )
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neurophysiology | Synaptic plasticity: striatal ltd | Ameliorated | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Communications | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
M_NLGN3_26_KI_R451C_HU-210
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Mice harboring the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7 were treated with CB1 receptor agonist HU-210 (1 microM, 20 min), as retrograde endocannabinoid signaling, acting through presynaptic CB1 receptors, is a well-established requirement for LTD expression and the authors sought to investigate the integrity and functional activity of CB1 receptor function in striatal neurons of R451C-NL3 mice.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: B6*129
Es cell line: Not Specified
Model Source: Sudhof laboratory (PMID 17823315 )
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neurophysiology | Synaptic plasticity: striatal ltd | Ameliorated | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Communications | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
M_NLGN3_26_KI_R451C_QUINPIROLE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Mice harboring the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7 were treated with quinpirole (10 microM, 20 min), an agonist of D2 dopamine receptors to investigate whether activation of D2 dopamine receptors rescues LTD in R451C-NL3 striatal spiny projection neurons as activation of D2 dopamine receptors is necessary for LTD induction.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: B6*129
Es cell line: Not Specified
Model Source: Sudhof laboratory (PMID 17823315 )
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neurophysiology | Synaptic plasticity: striatal ltd | Refractory | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Membrane potential | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Communications | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
M_NLGN3_26_KI_R451C_URB
Model Type: RESCUE-Pharmaceutical
Model Genotype: Hemizygous
Mutation:
Mice harboring the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7 were treated with 1micromolar fatty acid amide hydrolase (FAAH) inhibitor URB 597 for 30 minutes, to investigate whether there was a deficit in endocannabinoid production in mutant striatal spiny projection neurons.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: B6*129
Es cell line: Not Specified
Model Source: Sudhof laboratory (PMID 17823315 )
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Neurophysiology | Synaptic plasticity: striatal ltd | Ameliorated | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No adverse effect | Whole-cell patch clamp | 2 month | Martella G , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Communications | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Martella G , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Martella G , et al. (2017) |
M_NLGN3_27_KD
Model Type: Genetic
Model Genotype: Wild type
Mutation:
For NL3 knockdown of 8-week-old male WT mice, pAAV-CMV-mCherry-shRNA-Nlgn3 (ObioTechnology, Shanghai, China) containing AAV-virus was injected (600 nL/hemisphere) into the mPFC.
Allele Type: Knockdown
Strain of Origin: Not Specified
Genetic Background: Not Specified
Es cell line: Not Specified
Model Source: The Jackson Laboratory
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Social behavior | Social memory | No change | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Social behavior | Social approach | No change | Three-chamber social approach test | 2-3 months | Cao W , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Communications | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Cao W , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Western blot | 4.5 months | Cao W , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | 2.75 months | Cao W , et al. (2018) |
M_NLGN3_28_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Nlgn3 knockout mice were generated using the Flexible Accelerated STOP Tetracycline Operator (tetO)-knockin (FAST) technology to insert a construct containing a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO) and loxP site
Allele Type: Knockout
Strain of Origin: 129S6/SvEvTac
Genetic Background: C57BL/6J
Es cell line: Not Specified
Model Source: 20163789
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Motor phenotype | General locomotor activity | Increased | Open field test | Adult | Bariselli S , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Neurophysiology | Neuroreceptor activity | Abnormal | Whole-cell patch clamp | 4-8 weeks | Bariselli S , et al. (2018) |
Repetitive behavior | Repetitive digging | Decreased | Marble-burying test | Adult | Bariselli S , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Sensory | Olfaction | No change | Olfactory discrimination test | Adult | Bariselli S , et al. (2018) |
Social behavior | Social habituation | Decreased | Habituation-dishabituation test | Adult | Bariselli S , et al. (2018) |
Social behavior | Social dishabituation | Decreased | Habituation-dishabituation test | Adult | Bariselli S , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Communications | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Emotion | Exploratory activity: habituation | No change | Habituation-dishabituation test | Adult | Bariselli S , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Learning & memory | Reward reinforced choice behavior | Decreased | Conditioned place preference test | Adult | Bariselli S , et al. (2018) |
Learning & memory | Olfactory learning and memory | Decreased | Olfactory discrimination test | Adult | Bariselli S , et al. (2018) |
Learning & memory | Object recognition memory | No change | Novel object recognition test | Adult | Bariselli S , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Molecular profile | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
M_NLGN3_29_KD
Model Type: Genetic
Model Genotype: Other
Mutation:
Injections of purified AAV2-DIO-miRNlgn3-GFP, AAV2-Synaptophysin-GFPand AAV2-DIO-miR-GFP were done at P5P6 DAT-Cre mice for developmental knockdown. The virus was incubated for 34 weeks prior to testing. (AAV2-DIO-miRNlgn3in DAT-Cre mice: VTA::DA^NL3KD)
Allele Type: Knockdown
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: Not Specified
Model Source: 30093665
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Motor phenotype | General locomotor activity | No change | Open field test | 1.7 months | Bariselli S , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Neurophysiology | Synaptic plasticity: ventral tegmental area ltp | Decreased | Whole-cell patch clamp | 4-8 weeks | Bariselli S , et al. (2018) |
Neurophysiology | Neuroreceptor activity | Abnormal | Whole-cell patch clamp | 4-8 weeks | Bariselli S , et al. (2018) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 2.7 months | Bariselli S , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Social behavior | Social habituation | Decreased | Habituation-dishabituation test | 2 months | Bariselli S , et al. (2018) |
Social behavior | Social dishabituation | Decreased | Habituation-dishabituation test | 2 months | Bariselli S , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Communications | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Learning & memory | Reward reinforced choice behavior | Decreased | Conditioned place preference test | 1.2-1.5 months | Bariselli S , et al. (2018) |
Learning & memory | Olfactory learning and memory | No change | Olfactory discrimination test | Not specified | Bariselli S , et al. (2018) |
Learning & memory | Object recognition memory | No change | Novel object recognition test | 1.7 months | Bariselli S , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Immunohistochemistry | ~11 weeks | Bariselli S , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Western blot | ~11 weeks | Bariselli S , et al. (2018) |
Molecular profile | Protein expression level evidence | No change | Western blot | ~11 weeks | Bariselli S , et al. (2018) |
M_NLGN3_2_KO
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exons 2 and 3 flanked by loxP sites, then removed by cre-mediated recombination.
Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: 129S1/Sv * 129X1/SvJ * C57BL/6
Es cell line: R1
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Motor phenotype | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: inhibitory | No change | Immunohistochemistry | 3 months | Tabuchi K , et al. (2007) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | No change | Immunohistochemistry | 3 months | Tabuchi K , et al. (2007) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | Synaptic transmission: excitatory | No change | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic plasticity: hippocampal ltp | No change | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | No change | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission | No change | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Spontaneous post synaptic events: inhibitory currents | Increased | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | Decreased | Whole-cell patch clamp | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | Synaptic transmission: inhibitory | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Synaptic transmission: excitatory | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Synaptic plasticity | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Spontaneous post synaptic events: inhibitory currents | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Neurophysiology | Spontaneous post synaptic events: excitatory currents | No change | Whole-cell patch clamp | Unreported | Tabuchi K , et al. (2007) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Sensory | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Social behavior | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Communications | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Developmental profile | General characteristics | No change | General observations | Unreported | Tabuchi K , et al. (2007) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Emotion | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Learning & memory | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Tabuchi K , et al. (2007) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Molecular profile | Targeted expression | Decreased | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Protein expression level evidence | No change | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Protein expression level evidence | No change | Western blot | 3 months | Tabuchi K , et al. (2007) |
Molecular profile | Protein expression level evidence | Decreased | Western blot | 3 months | Tabuchi K , et al. (2007) |
M_NLGN3_30_KD
Model Type: Genetic
Model Genotype: Other
Mutation:
Injections of purified AAV2-DIO-miRNlgn3-GFP, AAV2-Synaptophysin-GFPand AAV2-DIO-miR-GFP were done at 47 weeks for adult knockdown. The virus was incubated for 34 weeks prior to testing.
Allele Type: Knockdown
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: Not Specified
Model Source: 30093665
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Neurophysiology | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Social behavior | Social habituation | Decreased | Habituation-dishabituation test | Adult | Bariselli S , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Communications | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Learning & memory | Reward reinforced choice behavior | Decreased | Conditioned place preference test | Adult | Bariselli S , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Bariselli S , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Immunohistochemistry | Adult | Bariselli S , et al. (2018) |
M_NLGN3_31_KI_HE_R451C
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
B6;129-Nlgn3tm1Sud/J knock-in mice (R451C). Mice carry an R451C mutation in exon 7 of the Nlgn3 gene.
Allele Type: Knockin
Strain of Origin: Not reported
Genetic Background: C57Bl/6*129sV
Es cell line: Not reported
Model Source: gift from Dr. Andrea Barberis (Italian Institute of Technology, Genoa)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Motor phenotype | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: inhibitory | Increased | Western blot | 2 months | Trobiani L , et al. (2018) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | No change | Western blot | 2 months | Trobiani L , et al. (2018) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | Increased | Whole-cell patch clamp | 2 months | Trobiani L , et al. (2018) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | 2 months | Trobiani L , et al. (2018) |
Repetitive behavior | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Seizure | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Sensory | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Social behavior | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Physiological parameters | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Communications | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Developmental profile | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Emotion | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Immune response | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Learning & memory | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Maternal behavior | NA | Not reported | NA | NA | Trobiani L , et al. (2018) |
Molecular profile | Targeted expression | Decreased | Western blot | E12, 14, 16, 18, p5, 3 weeks, 2 months | Trobiani L , et al. (2018) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 2 months | Trobiani L , et al. (2018) |
Molecular profile | Protein localization: endoplasmic reticulum | Increased | Western blot | E18 | Trobiani L , et al. (2018) |
Molecular profile | Protein expression: in situ protein expression | Abnormal | Western blot | 2 months | Trobiani L , et al. (2018) |
Molecular profile | Protein expression level evidence | No change | Western blot | 2 months | Trobiani L , et al. (2018) |
Molecular profile | Protein expression level evidence | Increased | Western blot | 2 months | Trobiani L , et al. (2018) |
Molecular profile | Protein degradation: proteasome | Increased | Western blot | P20 | Trobiani L , et al. (2018) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | E18, 2months | Trobiani L , et al. (2018) |
M_NLGN3_32_KI_HE_HSE-AAA
Model Type: Genetic LOF
Model Genotype: Hemizygous
Mutation:
Knock-in mutant mice with the HSE/AAA mutation were generated using CRISPR/Cas9 genome editing. The mutations consists of H279A S280A and E281A triple mutation (HSE/AAA) altering His279, Ser380, and Glu281, which comprise a near the interaction site for PTPô and NRXNs.
Allele Type: knockin
Strain of Origin: C57Bl/6
Genetic Background: C57Bl/6
Es cell line: NA
Model Source: 33758193
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | Adult | Yoshida T et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Decreased | Immunostaining | Adult | Yoshida T et al. (2021) |
Neurophysiology | Synaptic transmission: inhibitory | No change | Whole-cell patch clamp | Adult | Yoshida T et al. (2021) |
Social behavior | Social interaction | Increased | Reciprocal social interaction test | Adult | Yoshida T et al. (2021) |
Social behavior | Social approach | Increased | Three-chamber social approach test | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein expression: In situ protein expression | No change | Western blot | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein expression: In situ protein expression | - | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein degradation: proteasome | No change | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein binding | Abnormal | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein binding | Increased | Co-immunoprecipitation | Adult | Yoshida T et al. (2021) |
M_NLGN3_32_KO_HE
Model Type: Genetic LOF
Model Genotype: Hemizygous
Mutation:
Exon sequence covering the translational start site and 574 bp of 5' coding sequence targeted for deletion by homologous recombination (existing construct as in m_nlgn3_4_ko but on a different background)
Allele Type: Knockout
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: Not specified
Model Source: Prof. Nils Brose (Max Planck Institute for Experimental Medicine) #16982420
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Hyperactivity | Increased | Home cage behavior | 12 weeks | Horner AE et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Reaction time: cognitive flexibility | Decreased | Pairwise visual discrimination task | 12 weeks | Horner AE et al. (2021) |
Learning & memory | Visual discrimination learning | Increased | Pairwise visual discrimination task | 12 weeks | Horner AE et al. (2021) |
Learning & memory | Reward reinforced choice behavior | No change | Operant conditioning paradigm | 12 weeks | Horner AE et al. (2021) |
Learning & memory | Reaction time: visual discrimination | No change | Pairwise visual discrimination task | 12 weeks | Horner AE et al. (2021) |
Learning & memory | Cognitive flexibility | Increased | Pairwise visual discrimination task | 12 weeks | Horner AE et al. (2021) |
M_NLGN3_33_KI_HE_MF-AA
Model Type: Genetic LOF
Model Genotype: Hemizygous
Mutation:
Knock-in mutant mice with the MF/AA mutation were generated using CRISPR/Cas9 genome editing. MF/AA consists of M614A and F615A double mutations which disturbs the interface between PTPô Ig2 and the C-terminal tail of NLGN3 ECD without any effect on the interaction with NRXNs.
Allele Type: knockin
Strain of Origin: C57Bl/6
Genetic Background: C57Bl/6
Es cell line: NA
Model Source: 33758193
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | Adult | Yoshida T et al. (2021) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Decreased | Immunostaining | Adult | Yoshida T et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Increased | Whole-cell patch clamp | Adult | Yoshida T et al. (2021) |
Neurophysiology | Miniature post synaptic current frequency: excitatory | Increased | Whole-cell patch clamp | Adult | Yoshida T et al. (2021) |
Social behavior | Social interaction | Increased | Reciprocal social interaction test | Adult | Yoshida T et al. (2021) |
Social behavior | Social approach | No change | Three-chamber social approach test | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein expression: In situ protein expression | Decreased | Whole-cell patch clamp | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein expression: In situ protein expression | - | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein degradation: proteasome | No change | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein binding | Abnormal | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Protein binding | Decreased | Co-immunoprecipitation | Adult | Yoshida T et al. (2021) |
M_NLGN3_34_CKO_HM
Model Type: Genetic LOF
Model Genotype: Hemizygous
Mutation:
Knockout mouse model lacking exon 7 through Cre deletion. Exon 7 encodes a half of the extracellular domain, and skipping of this exon is predicted to lead to a frame shift and a premature stop codon. Nlgn3 exon 7-deleted mice were generated by crossing heterozygous female XX^fR/C mice, which carry floxed exon 7 with a point mutation corresponding to the human NLGN3 R451C, with nestin-Cre transgenic male mice (+/nestin-cre) carrying the cre recombinase gene under the control of the rat nestin promoter and enhancer.
Allele Type: knockout
Strain of Origin: C57Bl/6
Genetic Background: C57Bl/6
Es cell line: NA
Model Source: 33758193
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | No change | Immunostaining | Adult | Yoshida T et al. (2021) |
Molecular profile | Signaling | Abnormal | Immunostaining | Adult | Yoshida T et al. (2021) |
M_NLGN3_3_KI_R451C
Model Type: Genetic
Model Genotype: Hemizygous, Homozygous
Mutation:
A BAC targeting vector with the mutation of CGT (arginine 451) to TGC (cysteine 451) in exon 7 replaced the wild-type sequence.
Allele Type: ASD LOF mutation
Strain of Origin: Not Specified
Genetic Background: C57BL/6
Es cell line: R1
Model Source: Not Specified
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | Sleep pattern | Abnormal | Electroencephalogram/electromyogram (eeg/emg) | 4.5 months | Liu JJ , et al. (2017) |
Circadian sleep/wake cycle | Rapid eye movement sleep (rems) | Abnormal | Electroencephalogram/electromyogram (eeg/emg) | 4.5 months | Liu JJ , et al. (2017) |
Circadian sleep/wake cycle | Non rapid eye movement sleep (nrems) | Abnormal | Electroencephalogram/electromyogram (eeg/emg) | 4.5 months | Liu JJ , et al. (2017) |
Circadian sleep/wake cycle | Circadian rhythm | Abnormal | Electroencephalogram/electromyogram (eeg/emg) | 4.5 months | Liu JJ , et al. (2017) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Motor phenotype | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Motor phenotype | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Motor phenotype | Righting response | Decreased | Righting reflex test | P2-p6 | Chadman KK , et al. (2009) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | Adult | Chadman KK , et al. (2009) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | Adult | Chadman KK , et al. (2009) |
Motor phenotype | Grip strength | Decreased | Wire hang test | Adult | Chadman KK , et al. (2009) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | Adult | Chadman KK , et al. (2009) |
Motor phenotype | General locomotor activity | No change | Open field test | Adult | Chadman KK , et al. (2009) |
Motor phenotype | General locomotor activity | Decreased | Open field test | Adult | Chadman KK , et al. (2009) |
Motor phenotype | Gait | No change | Footprint analysis | Adult | Chadman KK , et al. (2009) |
Motor phenotype | Gait | Abnormal | Footprint analysis | Adult | Chadman KK , et al. (2009) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial number | Increased | Immunofluorescence staining | 2-5 months | Matta SM et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial morphology | Abnormal | Immunofluorescence staining | 2-5 months | Matta SM et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Astrocyte number | No change | Immunofluorescence staining | 2-5 months | Matta SM et al. (2020) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Astrocyte morphology | Decreased | Immunofluorescence staining | 2-5 months | Matta SM et al. (2020) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Neurophysiology | Synaptic transmission: excitatory | Increased | Field potential recordings | Unreported | Etherton M , et al. (2011) |
Neurophysiology | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Repetitive behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Repetitive behavior | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Seizure | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Seizure | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Sensory | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Sensory | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Sensory | Startle response: acoustic stimulus | Decreased | Prepulse inhibition | Adult | Chadman KK , et al. (2009) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | Adult | Chadman KK , et al. (2009) |
Sensory | Hearing | No change | Prepulse inhibition | Adult | Chadman KK , et al. (2009) |
Social behavior | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Social behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Social behavior | Social scent marking or recognition | Increased | Homing test | P9 | Chadman KK , et al. (2009) |
Social behavior | Social scent marking or recognition | No change | Homing test | P9 | Chadman KK , et al. (2009) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | P19-p23 | Chadman KK , et al. (2009) |
Social behavior | Social approach | No change | Three-chamber social approach test | Adult | Chadman KK , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Physiological parameters | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Physiological parameters | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Communications | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Communications | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Communications | Ultrasonic vocalization | No change | Monitoring ultrasonic vocalizations | P2-p11 | Chadman KK , et al. (2009) |
Communications | Ultrasonic vocalization | Decreased | Monitoring ultrasonic vocalizations | P8 | Chadman KK , et al. (2009) |
Developmental profile | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Developmental profile | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Developmental profile | Size/growth | No change | General observations | Adult | Chadman KK , et al. (2009) |
Developmental profile | Size/growth | Increased | General observations | P6-p11 | Chadman KK , et al. (2009) |
Developmental profile | Size/growth | Decreased | General observations | Adult | Chadman KK , et al. (2009) |
Developmental profile | Size/growth | Decreased | General observations | P6-p12 | Chadman KK , et al. (2009) |
Emotion | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Emotion | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Emotion | Anxiety | No change | Elevated plus maze test | Adult | Chadman KK , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Immune response | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Immune response | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Learning & memory | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Learning & memory | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Learning & memory | Spatial reference memory | No change | Morris water maze test | Adult | Chadman KK , et al. (2009) |
Learning & memory | Spatial learning | No change | Morris water maze test | Adult | Chadman KK , et al. (2009) |
Learning & memory | Cued or contextual fear conditioning | No change | Fear conditioning test | Adult | Chadman KK , et al. (2009) |
Learning & memory | Cognitive flexibility | No change | Morris water maze test | Adult | Chadman KK , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Maternal behavior | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Maternal behavior | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
Molecular profile | Targeted expression | Decreased | Western blot | 3 months | Matta SM et al. (2020) |
Molecular profile | Protein expression: In situ protein expression | Abnormal | Western blot | 3 months | Matta SM et al. (2020) |
Molecular profile | NA | Not reported | NA | NA | Liu JJ , et al. (2017) |
Molecular profile | NA | Not reported | NA | NA | Etherton M , et al. (2011) |
Molecular profile | NA | Not reported | NA | NA | Chadman KK , et al. (2009) |
M_NLGN3_4_KO
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exon sequence covering the translational start site and 574 bp of 5' coding sequence targeted for deletion by homologous recombination.
Allele Type: Knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6NCrl
Es cell line: Not Specified
Model Source: 16982420
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 12-15 weeks | Radyushkin K , et al. (2009) |
Motor phenotype | Hyperactivity | Increased | Open field test | 12-15 weeks | Radyushkin K , et al. (2009) |
Motor phenotype | Hyperactivity | Increased | Elevated plus maze test | 12-15 weeks | Radyushkin K , et al. (2009) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Magnetic resonance imaging (mri) | 12-15 weeks | Radyushkin K , et al. (2009) |
Neurophysiology | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Repetitive behavior | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Seizure | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Sensory | Taste | No change | Sucrose preference test | 12-15 weeks | Radyushkin K , et al. (2009) |
Sensory | Sensorimotor gating | No change | Prepulse inhibition | 12-15 weeks | Radyushkin K , et al. (2009) |
Sensory | Olfaction | Decreased | Buried food test | 12-15 weeks | Radyushkin K , et al. (2009) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 12-15 weeks | Radyushkin K , et al. (2009) |
Social behavior | Social interaction | No change | Reciprocal social interaction test | 12-15 weeks | Radyushkin K , et al. (2009) |
Social behavior | Social approach | No change | Three-chamber social approach test | 12-15 weeks | Radyushkin K , et al. (2009) |
Physiological parameters | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Communications | Ultrasonic vocalization | Decreased | Monitoring ultrasonic vocalizations | 12-15 weeks | Radyushkin K , et al. (2009) |
Developmental profile | Size/growth | No change | General observations | 12-15 weeks | Radyushkin K , et al. (2009) |
Emotion | Exploratory activity | Increased | Hole-board test | 12-15 weeks | Radyushkin K , et al. (2009) |
Emotion | Anxiety | No change | Open field test | 12-15 weeks | Radyushkin K , et al. (2009) |
Emotion | Anxiety | No change | Elevated plus maze test | 12-15 weeks | Radyushkin K , et al. (2009) |
Immune response | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Learning & memory | Spatial reference memory | No change | Morris water maze test | 12-15 weeks | Radyushkin K , et al. (2009) |
Learning & memory | Spatial learning | No change | Morris water maze test | 12-15 weeks | Radyushkin K , et al. (2009) |
Learning & memory | Spatial learning | No change | Morris water maze test | 12-15 weeks | Radyushkin K , et al. (2009) |
Learning & memory | Cued or contextual fear conditioning: memory of cue | Decreased | Fear conditioning test | 12-15 weeks | Radyushkin K , et al. (2009) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Decreased | Fear conditioning test | 12-15 weeks | Radyushkin K , et al. (2009) |
Learning & memory | Cognitive flexibility | Increased | Morris water maze test | 12-15 weeks | Radyushkin K , et al. (2009) |
Maternal behavior | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
Molecular profile | NA | Not reported | NA | NA | Radyushkin K , et al. (2009) |
M_NLGN3_5_KO
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exons 2 and 3 flanked by loxP sites, then removed by cre-mediated recombination.
Allele Type: Knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | Stereotypy | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Repetitive behavior | Stereotypy | Increased | Force plate actometer test | 6 weeks | Rothwell PE , et al. (2014) |
Repetitive behavior | Perseveration | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | Anxiety | No change | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_6_KI_R451C
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exon 7 carrying coding mutation (R451C) replaced the wild type exon 7 using a neo cassette as a selectable marker and flanked by loxP sites.
Allele Type: ASD LOF mutation
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: enteric neurons | No change | Immunohistochemistry | 8-14 weeks | Lee CYQ et al. (2023) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | Stereotypy | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Repetitive behavior | Perseveration | Increased | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | Digestive system function: mucosal morphology: mucosal growth | No change | Histology | 8-14 weeks | Lee CYQ et al. (2023) |
Physiological parameters | Digestive system function: intestinal barrier: intestinal permeability | No change | Intestinal permeability test | 8-14 weeks | Lee CYQ et al. (2023) |
Physiological parameters | Digestive system function: gastrointestinal motility: peristaltic reflexes | Increased | Measurement of GI motility | 8-14 weeks | Lee CYQ et al. (2023) |
Physiological parameters | Digestive system function: gastrointestinal motility: intestinal motility | Abnormal | Measurement of GI motility | 8-14 weeks | Lee CYQ et al. (2023) |
Physiological parameters | Digestive system function: gastrointestinal motility: colonic motility | Abnormal | Measurement of GI motility | 8-14 weeks | Lee CYQ et al. (2023) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | Tissue weight | Decreased | Measurement of tissue weight | 8-14 weeks | Lee CYQ et al. (2023) |
Developmental profile | Digestive system morphology | No change | Histology | 8-14 weeks | Lee CYQ et al. (2023) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | Anxiety | No change | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Immune response | Development of immune cells and primary lymphoid organs | Increased | Macroscopic analysis | 8-14 weeks | Lee CYQ et al. (2023) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_7_CKO_NESTIN-CRE
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Conditional deletion of exons 2-3 of Nlgn3 using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | Targeted expression | Decreased | Western blot | 4 weeks | Rothwell PE , et al. (2014) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 4 weeks | Rothwell PE , et al. (2014) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 4 weeks | Rothwell PE , et al. (2014) |
M_NLGN3_8_CKO_HM_PURKINJEN
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exons 2-3 of Nlgn3 using L7-cre in Purkinje cells of the cerebellum
Allele Type: Conditional knockout
Strain of Origin: Not Specified
Genetic Background: C57BL/6*129Sv/CD1
Es cell line: Not Specified
Model Source: Jackson Labs
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | Spontaneous post synaptic events: inhibitory currents | No change | Whole-cell patch clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No change | Whole-cell patch clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell current clamp | 1.2 months | Zhang B , et al. (2015) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | No change | Whole-cell patch clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | Miniature post synaptic current amplitude: excitatory | Decreased | Whole-cell current clamp | 1.2 months | Zhang B , et al. (2015) |
Neurophysiology | Intrinsic membrane properties | No change | Whole-cell patch clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | Decay kinetics of miniature post synaptic currents | No change | Whole-cell current clamp | P21-25 | Zhang B , et al. (2015) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Zhang B , et al. (2015) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | Targeted expression | Decreased | Western blot | Unreported | Zhang B , et al. (2015) |
Molecular profile | Protein expression level evidence | No change | Western blot | Unreported | Zhang B , et al. (2015) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
M_NLGN3_8_CKO_L7-CRE
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Exons 2 and 3 flanked by loxP sites, L7-Cre transgene.
Allele Type: Conditional knockout
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hyperactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
M_NLGN3_9_CKO_HM_PVALBN
Model Type: Genetic
Model Genotype: Hemizygous
Mutation:
Conditional deletion of exons 2-3 of Nlgn3 using Pvalb-Cre, in parvalbumin expressing interneurons
Allele Type: Conditional loss-of-function
Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl+
Genetic Background: C57BL/6J
Es cell line: R1
Model Source: -
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 6 weeks | Rothwell PE , et al. (2014) |
Motor phenotype | Hypoactivity | Increased | Open field test | 6 weeks | Rothwell PE , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Neurophysiology | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Repetitive behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Seizure | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Sensory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Social behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Physiological parameters | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Communications | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Developmental profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Emotion | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Immune response | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Learning & memory | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Maternal behavior | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Molecular profile | NA | Not reported | NA | NA | Rothwell PE , et al. (2014) |
Other NLGN3 Rescue Models(10 Models)
M_NLGN3_16_KO_HM | 2 | Genetic | Pharmaceutical | ETC-168 |
M_NLGN3_16_KO_HM | 4 | Genetic | Genetic | Nlgn3 |
M_NLGN3_10_CKO_HM | 1 | Genetic | Genetic | DIO-NL3 transgene in nucleus accumbens |
M_NLGN3_19_KO_HE | 1 | Genetic | Genetic | Nlgn3 reexpression |
M_NLGN3_26_KI_R451C | 1 | Genetic | Pharmaceutical | ACEA |
M_NLGN3_26_KI_R451C | 1 | Genetic | Pharmaceutical | HU-210 |
M_NLGN3_26_KI_R451C | 1 | Genetic | Pharmaceutical | Quinpirole |
M_NLGN3_26_KI_R451C | 1 | Genetic | Pharmaceutical | URB597 |
M_NLGN3_21_KI_R451C | 1 | Genetic | Genetic | Optogenetic activation of Pvalb interneurons |
M_NLGN3_21_KI_R451C | 1 | Genetic | Genetic | NLGN3 |
CNVs associated with NLGN3(1 Models)
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Xq13.1 | 15 | Deletion-Duplication | 25 / 42 |