Genetic Animal Models / PCDH19

PCDH19 protocadherin 19

Model Species
Rattus norvegicus
Gene Aliases
RGD1565392
Reports
1
Associated Human Genes
PCDH19
Models / Rescue Models
2 / 1
Rescue Model
-
Model Summary

Pcdh19 knockdown rats show abnormal hippocampal neuron morphology and increased susceptibility to seizures.

Reports related to PCDH19 (1 Reports)
# Type Title Author, Year
1 Primary The female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological mat... Bassani S , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

R_PCDH19_1_KD

Model Type: Genetic
Model Genotype: Wild type

Mutation:

In utero electroporation of shRNA to silence expression of Pcdh19 gene.

Allele Type: Knockdown
Strain of Origin: -
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: Harlan Italy SRL
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Bassani S , et al. (2018)
Motor phenotype - Not Reported - - Bassani S , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Abnormal Confocal microscopy P7 Bassani S , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Abnormal Confocal microscopy P7 Bassani S , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Confocal microscopy P7 Bassani S , et al. (2018)
Neurophysiology - Not Reported - - Bassani S , et al. (2018)
Repetitive behavior - Not Reported - - Bassani S , et al. (2018)
Seizure Seizure threshold Decreased Observation of chemically induced seizures P7 Bassani S , et al. (2018)
Sensory - Not Reported - - Bassani S , et al. (2018)
Social behavior - Not Reported - - Bassani S , et al. (2018)
Communications - Not Reported - - Bassani S , et al. (2018)
Developmental profile - Not Reported - - Bassani S , et al. (2018)
Emotion - Not Reported - - Bassani S , et al. (2018)
Homeostasis - Not Reported - - Bassani S , et al. (2018)
Immune response - Not Reported - - Bassani S , et al. (2018)
Learning & memory - Not Reported - - Bassani S , et al. (2018)
Maternal behavior - Not Reported - - Bassani S , et al. (2018)
Molecular profile - Not Reported - - Bassani S , et al. (2018)

R_PCDH19_1_KD_hPCDH19

Model Type: RESCUE-Genetic
Model Genotype: Wild type

Mutation:

In utero electroporation of shRNA to silence expression of Pcdh19 gene and of overexpression construct for human PCDH19.

Allele Type: Knockdown
Strain of Origin: -
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: Harlan Italy SRL
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Bassani S , et al. (2018)
Motor phenotype - Not Reported - - Bassani S , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Restored Confocal microscopy P7 Bassani S , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Restored Confocal microscopy P7 Bassani S , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Restored Confocal microscopy P7 Bassani S , et al. (2018)
Neurophysiology - Not Reported - - Bassani S , et al. (2018)
Repetitive behavior - Not Reported - - Bassani S , et al. (2018)
Seizure Seizure threshold Restored Observation of chemically induced seizures P7 Bassani S , et al. (2018)
Sensory - Not Reported - - Bassani S , et al. (2018)
Social behavior - Not Reported - - Bassani S , et al. (2018)
Communications - Not Reported - - Bassani S , et al. (2018)
Developmental profile - Not Reported - - Bassani S , et al. (2018)
Emotion - Not Reported - - Bassani S , et al. (2018)
Homeostasis - Not Reported - - Bassani S , et al. (2018)
Immune response - Not Reported - - Bassani S , et al. (2018)
Learning & memory - Not Reported - - Bassani S , et al. (2018)
Maternal behavior - Not Reported - - Bassani S , et al. (2018)
Molecular profile - Not Reported - - Bassani S , et al. (2018)
Other PCDH19 Rescue Models(1 Models)
R_PCDH19_1_KD 1 Genetic Genetic hPCDH19
CNVs associated with PCDH19(1 Models)
Xq22.1 7 Duplication 11  /  18
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