Genetic Animal Models / PRKN

PRKN parkin RBR E3 ubiquitin protein ligase

Model Species
Rattus norvegicus
Gene Aliases
Park, Park2
Reports
1
Associated Human Genes
PRKN
Models / Rescue Models
-
Rescue Model
-
Model Summary

Parkin knockouts show altered dopaminergic signaling, and decreased methamphetamine-induced hyperactivity.

Reports related to PRKN (1 Reports)
# Type Title Author, Year
1 Primary Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats. Gemechu JM , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

R_PRKN_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Zinc finger nuclease-directed 5-base pair deletion in exon 4 that results in a frameshift mutation.

Allele Type: Knockout
Strain of Origin: -
Genetic Background: Long Evans

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Core body temperature No Change Body temperature measurement 2 months Gemechu JM , et al. (2018)
Circadian sleep/wake cycle - Not Reported - - Gemechu JM , et al. (2018)
Motor phenotype Hyperactivity Decreased Open field test 2 months Gemechu JM , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No Change Open field test 2 months Gemechu JM , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic neuroreceptors Decreased Western blot 2 months Gemechu JM , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic neuroreceptors No Change Western blot 2 months Gemechu JM , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neurotransporter expression No Change Western blot 2 months Gemechu JM , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: DA Decreased Western blot 2 months Gemechu JM , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cytoskeletal organization: neuronal Abnormal Western blot: fractionation 2 months Gemechu JM , et al. (2018)
Neurophysiology Neurotransmitter release: serotonin No Change High-performance liquid chromatography (HPLC) 2 months Gemechu JM , et al. (2018)
Neurophysiology Neurotransmitter release: catecholamines: dopamine No Change High-performance liquid chromatography (HPLC) 2 months Gemechu JM , et al. (2018)
Neurophysiology Neurotransmitter release No Change Liquid chromatography-mass spectrometry (LC-MS) 2 months Gemechu JM , et al. (2018)
Neurophysiology Neurotransmitter release Increased Liquid chromatography-mass spectrometry (LC-MS) 2 months Gemechu JM , et al. (2018)
Neurophysiology Neurotransmitter metabolism No Change Western blot: fractionation 2 months Gemechu JM , et al. (2018)
Repetitive behavior Stereotypy Decreased Open field test 2 months Gemechu JM , et al. (2018)
Seizure - Not Reported - - Gemechu JM , et al. (2018)
Sensory - Not Reported - - Gemechu JM , et al. (2018)
Social behavior - Not Reported - - Gemechu JM , et al. (2018)
Communications - Not Reported - - Gemechu JM , et al. (2018)
Developmental profile Size/growth Increased Body weight measurement 4-9 weeks Gemechu JM , et al. (2018)
Emotion - Not Reported - - Gemechu JM , et al. (2018)
Homeostasis - Not Reported - - Gemechu JM , et al. (2018)
Immune response - Not Reported - - Gemechu JM , et al. (2018)
Learning & memory - Not Reported - - Gemechu JM , et al. (2018)
Maternal behavior - Not Reported - - Gemechu JM , et al. (2018)
Molecular profile Targeted expression Decreased Western blot 2 months Gemechu JM , et al. (2018)
Molecular profile Protein ubiquitination No Change Western blot 2 months Gemechu JM , et al. (2018)
Molecular profile Protein expression level evidence No Change Western blot 2 months Gemechu JM , et al. (2018)
Molecular profile Protein binding Decreased Western blot 2 months Gemechu JM , et al. (2018)
Molecular profile Gene expression No Change Quantitative PCR (qRT-PCR) 2 months Gemechu JM , et al. (2018)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 2 months Gemechu JM , et al. (2018)
Molecular profile Enzyme activity Decreased Enzyme assay 2 months Gemechu JM , et al. (2018)
CNVs associated with PRKN(1 Models)
6q26 36 Deletion-Duplication 61  /  319
Submit New Gene

Report an Error