Genetic Mouse Models / PTEN

PTEN phosphatase and tensin homolog

Model Species
Mus musculus
Gene Aliases
2310035O07Rik, A130070J02Rik, AI463227, MMAC1, TEP1
Reports
17
Associated Human Genes
PTEN
Models / Rescue Models
29 / 6
Rescue Model
-
Model Summary

Mutant mice display abnormal social interaction and exaggerated responses to sensory stimuli.

Reports related to PTEN (17 Reports)
# Type Title Author, Year
1 Primary Pten regulates neuronal arborization and social interaction in mice. Kwon CH , et al. (2006)
2 Primary Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. Zhou J , et al. (2009)
3 Additional Allele-specific tumor spectrum in pten knockin mice. Wang H , et al. (2010)
4 Additional Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. Napoli E , et al. (2012)
5 Additional Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism. Takeuchi K , et al. (2013)
6 Additional Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests. Clipperton-Allen AE and Page DT (2014)
7 Additional Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism. Frazier TW , et al. (2014)
8 Additional Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice. Clipperton-Allen AE and Page DT (2015)
9 Additional Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive. Williams MR , et al. (2015)
10 Additional The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Vogt D , et al. (2015)
11 Additional Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice. Cupolillo D , et al. (2015)
12 Additional Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior. Smith GD , et al. (2016)
13 Additional Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice. Cabral-Costa JV , et al. (2018)
14 Additional PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior. Snchez-Puelles C , et al. (2019)
15 Additional Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Chen CJ , et al. (2019)
16 Additional Interneuron Transplantation Rescues Social Behavior Deficits Without Restoring Wild-Type Physiology in a Mouse Model of Autism With Excessive Synaptic Inhibition </title> ()
17 Additional Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations Xu ZX et al. (2020)
Show all Construct Details Show all Phenotypic Profiles

M_PTEN_10_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 4-5 of of PTEN using Dlxl12b-cre mice, in gabaergic interneurons of the forebrain, by E15.5. Authors report assessments looking into the secondary progenitor cells of the subventricular zone of the subpallium

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry P18 Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Anatomical projections and connectivity Increased Immunohistochemistry P18 Vogt D , et al. (2015)
Neurophysiology NA Not reported NA NA Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile Mortality/lethality Increased Survival analysis P18 Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)

M_PTEN_10_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exons 4-5 of of PTEN using Dlxl12b-cre mice, in gabaergic neurons of the forebrain, by E15.5. Authors report assessments looking into the secondary progenitor cells of the subventricular zone of the subpallium

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal specification No change NA 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry 4 weeks Vogt D , et al. (2015)
Neurophysiology NA Not reported NA NA Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile NA Not reported NA NA Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)

M_PTEN_11_CKO_HM_SSTN

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 4 - 5 using SST-IRES-Cre, in postmitotic somatostatin expressing cells as they leave the medial ganglionic eminence. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1* C56BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Anatomical projections and connectivity No change Immunohistochemistry 4 weeks Vogt D , et al. (2015)
Neurophysiology NA Not reported NA NA Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile NA Not reported NA NA Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)

M_PTEN_11_CKO_HT_SSTN

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exons 4 - 5 using SST-IRES-Cre, in postmitotic somatostatin expressing cells as they leave the medial ganglionic eminence. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal specification No change NA P18 Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry P18 Vogt D , et al. (2015)
Neurophysiology NA Not reported NA NA Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile NA Not reported NA NA Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)

M_PTEN_12_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

In this cell transplant based model, cells from with a homozygous loss of Pten using Dlxl12b-Cre+ were extracted from E12.5 embryos, then transplanted to wild type recipient mice at P1 to see how complete loss of Pten from the secondary progenitors in the subventricular zone (SVZ) of the entire subpallium, affects cell differentiation. The recipient mouse neocortices were then examined 35 days following transplantation.

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size Increased Immunohistochemistry 35dpt Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation Decreased NA 35dpt Vogt D , et al. (2015)
Neurophysiology Intrinsic membrane properties Decreased Whole-cell patch clamp 45dpt Vogt D , et al. (2015)
Neurophysiology Action potential property: firing rate No change Whole-cell patch clamp 45dpt Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile NA Not reported NA NA Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)

M_PTEN_12_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

In this cell transplant based model, cells from with a heterozygous loss of Pten using Dlxl12b-Cre+ were extracted from E12.5 embryos, then transplanted to wild type recipient mice at P1 to see howpartial loss of Pten from the secondary progenitors in the subventricular zone (SVZ) of the entire subpallium, affects cell differentiation. he recipient mouse neocortices were then examined 35 days following transplantation.

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size No change Immunohistochemistry 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation Decreased NA 4 weeks Vogt D , et al. (2015)
Neurophysiology NA Not reported NA NA Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile NA Not reported NA NA Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)

M_PTEN_13_KI_HM

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Partial loss-of-function knockin mice with truncated Pten gene lacking its C-terminal PDZ motif, Pten^tm(Q399stop)amc, were generated by homologous recombination in iTL1 129S6/SvEvBrdTac(129Sv)-derived embryonic stem cells where residues 399 to 403 were truncated. The PDZ-binding domain was deleted by substituting codon 399 (CAA) with a stop codon (TAA), as previously described (Knafo et al. 2016, PMID 26780512). These mice express normal levels of total Pten protein and normal Pten catalytic activity.

Allele Type: LOF Knockin
Strain of Origin: 129S6/SvEvBrdTac(129Sv)
Genetic Background: C57BL/6

Es cell line: 129S6/SvEvBrdTac(129Sv)
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Motor phenotype NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density No change Electron microscopy 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size No change Electron microscopy 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the amygdala No change Stereology 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Stereology 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: ltd No change Field potential recordings 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: ltd Decreased Field potential recordings 6-12 months Snchez-Puelles C , et al. (2019)
Repetitive behavior NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Seizure NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Sensory NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 6-12 months Snchez-Puelles C , et al. (2019)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations; P3-p12 Snchez-Puelles C , et al. (2019)
Developmental profile Size/growth No change Measurement of body weight 6-12 months Snchez-Puelles C , et al. (2019)
Emotion Anxiety No change Elevated plus maze test 6-12 months Snchez-Puelles C , et al. (2019)
Immune response NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test 6-12 months Snchez-Puelles C , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 6-12 months Snchez-Puelles C , et al. (2019)
Maternal behavior NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Molecular profile NA Not reported NA NA Snchez-Puelles C , et al. (2019)

M_PTEN_14_TG

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Gain-of-function mutant mice with increased Pten copy number (Pten^tg) that overexpress Pten protein were generated by bacterial artificial chromosome (BAC) transgenesis on a C57BL6/CBA genetic background as previously described in Ortega-Molina et al. 2012, PMID 22405073 (gift from the lab of Manuel Serrano, IRB, Barcelona, Spain).

Allele Type: Overexpression
Strain of Origin: -
Genetic Background: C57BL6*CBA

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Motor phenotype NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory Decreased Electron microscopy 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size No change Electron microscopy 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size Decreased Electron microscopy 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the amygdala No change Cranial computerized tomography (ct) scan 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Decreased Cranial computerized tomography (ct) scan 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Sholl analysis 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis 6-12 months Snchez-Puelles C , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Stereology 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: ltd No change Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: ltd Increased Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: hippocampal ltp Decreased Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: amygdalar ltp Decreased Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Synaptic plasticity: amygdalar ltp No change Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Neuronal activation following behavioral stimulation Decreased Positron emission tomography (pet) imaging 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Neuronal activation No change Positron emission tomography (pet) imaging 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Neuronal activation Decreased Positron emission tomography (pet) imaging 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Neuronal activation Increased Positron emission tomography (pet) imaging 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Intrinsic membrane properties No change Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Intrinsic membrane properties Decreased Whole-cell patch clamp 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Epsp-spike relationship Decreased Field potential recordings 6-12 months Snchez-Puelles C , et al. (2019)
Neurophysiology Epsp-spike relationship No change Field potential recordings 6-12 months Snchez-Puelles C , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 6-12 months Snchez-Puelles C , et al. (2019)
Seizure NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Sensory Pain or nociception No change Foot shock test 6-12 months Snchez-Puelles C , et al. (2019)
Social behavior Social approach Increased Three-chamber social approach test 6-12 months Snchez-Puelles C , et al. (2019)
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations; P3-p12 Snchez-Puelles C , et al. (2019)
Developmental profile Size/growth Decreased Body weight measurement 6-12 months Snchez-Puelles C , et al. (2019)
Emotion Habituation to aversive stimuli No change Fear conditioning test 6-12 months Snchez-Puelles C , et al. (2019)
Emotion Exploratory activity No change Open field test 6-12 months Snchez-Puelles C , et al. (2019)
Emotion Anxiety Decreased Elevated plus maze test 6-12 months Snchez-Puelles C , et al. (2019)
Immune response NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Learning & memory Spatial working memory Decreased Barnes maze test 6-12 months Snchez-Puelles C , et al. (2019)
Learning & memory Spatial reference memory No change Barnes maze test 6-12 months Snchez-Puelles C , et al. (2019)
Learning & memory Object recognition memory No change Object-place recognition test 6-12 months Snchez-Puelles C , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of cue Decreased Fear conditioning test 6-12 months Snchez-Puelles C , et al. (2019)
Learning & memory Cognitive flexibility Decreased Barnes maze test 6-12 months Snchez-Puelles C , et al. (2019)
Maternal behavior NA Not reported NA NA Snchez-Puelles C , et al. (2019)
Molecular profile NA Not reported NA NA Snchez-Puelles C , et al. (2019)

M_PTEN_17_CKO_HM_PURKINJEN

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 5 of the Pten gene using L7-Cre in Purkinje cells of the cerebellum

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Reproductive function No change General observations Adult Cupolillo D , et al. (2015)
Physiological parameters NA Not reported NA NA Cupolillo D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Cupolillo D , et al. (2015)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 2-3 months Cupolillo D , et al. (2015)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 5-6 months Cupolillo D , et al. (2015)
Motor phenotype General locomotor activity No change Three-chamber social approach test 4 months Cupolillo D , et al. (2015)
Motor phenotype General locomotor activity No change Open field test 4 months Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size Increased Cell size measurement 2 months, 4 months, 9 months Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6 months Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Immunohistochemistry 2 months, 4 months, 6 months Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Increased Immunohistochemistry 2 months, 4 months, 6 months Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cytoskeletal organization: neuronal Increased Immunohistochemistry NA Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology: molecular layer thickness Increased Immunostaining 2months, 4 months Cupolillo D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology No change Histology 2-3 months Cupolillo D , et al. (2015)
Neurophysiology Synaptic transmission: excitatory Increased Cell-attached patch clamp 3-4.5 months Cupolillo D , et al. (2015)
Neurophysiology Synaptic transmission: excitatory Increased Cell-attached patch clamp 3-4.5 months Cupolillo D , et al. (2015)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Paired-pulse ratio 3-4.5 months Cupolillo D , et al. (2015)
Neurophysiology Presynaptic function: paired-pulse depression (ppd) Decreased Whole-cell patch clamp 3-4.5 months Cupolillo D , et al. (2015)
Neurophysiology Apoptosis: brain cells Increased Expression of cleaved caspase-3 (cc3) 9 months Cupolillo D , et al. (2015)
Neurophysiology Action potential property: firing rate Decreased Cell-attached patch clamp 3-4.5 months Cupolillo D , et al. (2015)
Repetitive behavior Vertical jumping or back flipping Increased Observation of repetitive behavior 3-4months Cupolillo D , et al. (2015)
Repetitive behavior Self grooming: perseveration Decreased Grooming behavior assessments 3-4 months Cupolillo D , et al. (2015)
Seizure NA Not reported NA NA Cupolillo D , et al. (2015)
Sensory NA Not reported NA NA Cupolillo D , et al. (2015)
Social behavior Social interaction: opposite sex Decreased Reciprocal social interaction test 3-4months Cupolillo D , et al. (2015)
Social behavior Social approach Decreased Three-chamber social approach test 3-4months Cupolillo D , et al. (2015)
Social behavior Social approach Decreased Open field test 3-4months Cupolillo D , et al. (2015)
Communications NA Not reported NA NA Cupolillo D , et al. (2015)
Developmental profile Mortality/lethality No change General observations Adult Cupolillo D , et al. (2015)
Emotion NA Not reported NA NA Cupolillo D , et al. (2015)
Immune response NA Not reported NA NA Cupolillo D , et al. (2015)
Learning & memory Spatial reference memory No change Morris water maze test Adult Cupolillo D , et al. (2015)
Learning & memory Spatial learning No change Morris water maze test Adult Cupolillo D , et al. (2015)
Learning & memory Cognitive flexibility No change Morris water maze test Adult Cupolillo D , et al. (2015)
Learning & memory Cognitive flexibility No change Water t-maze test Adult Cupolillo D , et al. (2015)
Maternal behavior NA Not reported NA NA Cupolillo D , et al. (2015)
Molecular profile Signaling Increased Immunohistochemistry 4 months Cupolillo D , et al. (2015)

M_PTEN_18_CKO_HT_SEIZURE

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Multifactorial model, Pten CKO mice, with deletion of exons 4 and 5 using GFAP-cre, authors indicate that the is KO localized to the hippocampal granule cells of the dentate gyrus, by P5. These PTEN het CKO mice were treated with 20mg/kg (in 0.9% saline) of kainate (ip) beginning at P60 (2 months age). At approximately 1 hour following saline (control) or kainate injections, all mice received an ip injection of pentobarbital (20mg/kg) to terminate seizure activity. All behavioral testing was carried out 1 week after seizure induction, only mice that had entered the status epilepticus so that they all fell into the category of highest seizure severity were used in the studies.

Allele Type: Multifactorial
Strain of Origin: 129P2/OlaHsd
Genetic Background: FVB*mixed

Es cell line: E14K
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Smith GD , et al. (2016)
Circadian sleep/wake cycle NA Not reported NA NA Smith GD , et al. (2016)
Motor phenotype Swimming ability No change Morris water maze test 12-13 weeks Smith GD , et al. (2016)
Motor phenotype Hyperactivity Increased Open field test 9 weeks Smith GD , et al. (2016)
Motor phenotype Hyperactivity Increased Elevated plus maze test 9 weeks Smith GD , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Smith GD , et al. (2016)
Neurophysiology NA Not reported NA NA Smith GD , et al. (2016)
Repetitive behavior Self grooming: perseveration No change Open field test 9 weeks Smith GD , et al. (2016)
Repetitive behavior Repetitive digging No change Marble-burying test 10 weeks Smith GD , et al. (2016)
Repetitive behavior Circling No change Open field test 9 weeks Smith GD , et al. (2016)
Seizure NA Not reported NA NA Smith GD , et al. (2016)
Sensory NA Not reported NA NA Smith GD , et al. (2016)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Smith GD , et al. (2016)
Communications NA Not reported NA NA Smith GD , et al. (2016)
Developmental profile NA Not reported NA NA Smith GD , et al. (2016)
Emotion Exploratory activity No change Three-chamber social approach test 10 weeks Smith GD , et al. (2016)
Emotion Anxiety No change Open field test 9 weeks Smith GD , et al. (2016)
Immune response NA Not reported NA NA Smith GD , et al. (2016)
Learning & memory Spatial reference memory No change Morris water maze test 13 weeks Smith GD , et al. (2016)
Learning & memory Spatial learning No change Morris water maze test 13 weeks Smith GD , et al. (2016)
Learning & memory Cued or contextual fear conditioning: trace fear conditioning Increased Fear conditioning test 12 weeks Smith GD , et al. (2016)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 12 weeks Smith GD , et al. (2016)
Maternal behavior NA Not reported NA NA Smith GD , et al. (2016)
Molecular profile Protein phosphorylation No change Western blot 14 weeks Smith GD , et al. (2016)
Molecular profile Protein localization: synapse No change Western blot 14 weeks Smith GD , et al. (2016)
Molecular profile Protein expression level evidence No change Western blot 14 weeks Smith GD , et al. (2016)

M_PTEN_19_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Exon 4 and 5 are floxed by introducing loxP sites in introns 3 and 5, homozygous mice are obtained by breeding heterozygous knockouts following germline transmission of exon4-5 deletion.

Allele Type: -
Strain of Origin: -
Genetic Background: FVB/N *129Sv/Ev* Black swiss

Es cell line: -
Model Source: PMID: 20194734
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Wang H , et al. (2010)
Circadian sleep/wake cycle NA Not reported NA NA Wang H , et al. (2010)
Motor phenotype NA Not reported NA NA Wang H , et al. (2010)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Wang H , et al. (2010)
Neurophysiology NA Not reported NA NA Wang H , et al. (2010)
Repetitive behavior NA Not reported NA NA Wang H , et al. (2010)
Seizure NA Not reported NA NA Wang H , et al. (2010)
Sensory NA Not reported NA NA Wang H , et al. (2010)
Social behavior NA Not reported NA NA Wang H , et al. (2010)
Communications NA Not reported NA NA Wang H , et al. (2010)
Developmental profile Mortality/lethality: embryonic Increased Survival analysis E9.5 Wang H , et al. (2010)
Emotion NA Not reported NA NA Wang H , et al. (2010)
Immune response NA Not reported NA NA Wang H , et al. (2010)
Learning & memory NA Not reported NA NA Wang H , et al. (2010)
Maternal behavior NA Not reported NA NA Wang H , et al. (2010)
Molecular profile NA Not reported NA NA Wang H , et al. (2010)

M_PTEN_1_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 4-5 of the Pten gene using Nse-cre, authors in PMID 23487788 (Takeuchi K et al 2013) specifically show loss of Pten in granule cells of dentate gyrus and pyramidal neurons of hippocampal CA3 and a subset of postmitotic neruons in the cortex. Same CKOs produced in PMID:16675393

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6

Es cell line: E14K
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Takeuchi K , et al. (2013)
Physiological parameters NA Not reported NA NA Kwon CH , et al. (2006)
Circadian sleep/wake cycle NA Not reported NA NA Takeuchi K , et al. (2013)
Circadian sleep/wake cycle NA Not reported NA NA Kwon CH , et al. (2006)
Motor phenotype NA Not reported NA NA Takeuchi K , et al. (2013)
Motor phenotype Motor strength and endurance No change Vertical pole test Unreported Kwon CH , et al. (2006)
Motor phenotype Motor strength and endurance No change Dowel walk test Unreported Kwon CH , et al. (2006)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test Unreported Kwon CH , et al. (2006)
Motor phenotype General locomotor activity Abnormal Open field test 6 weeks Kwon CH , et al. (2006)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Histology 5 months Takeuchi K , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Abnormal Immunohistochemistry 10.7 months Kwon CH , et al. (2006)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Abnormal Immunohistochemistry 3-9 months Kwon CH , et al. (2006)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Histology Unreported Kwon CH , et al. (2006)
Neurophysiology Synaptic transmission No change Whole-cell patch clamp 8-30 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic transmission No change Whole-cell patch clamp 8-20 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic transmission Increased Whole-cell patch clamp 3.5-5 months Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity No change Whole-cell patch clamp 8-12 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity No change Whole-cell patch clamp 8-20 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Increased Whole-cell patch clamp 8-12 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Decreased Whole-cell patch clamp 4-5months Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Decreased Whole-cell patch clamp 2-7.5 months Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Decreased Whole-cell patch clamp 3.5-7.5 months Takeuchi K , et al. (2013)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp 8-30 weeks Takeuchi K , et al. (2013)
Neurophysiology Presynaptic function: paired-pulse facilitation Decreased Whole-cell patch clamp 3.5-5 months Takeuchi K , et al. (2013)
Neurophysiology NA Not reported NA NA Kwon CH , et al. (2006)
Repetitive behavior NA Not reported NA NA Takeuchi K , et al. (2013)
Repetitive behavior NA Not reported NA NA Kwon CH , et al. (2006)
Seizure NA Not reported NA NA Takeuchi K , et al. (2013)
Seizure Seizures Abnormal Observation of seizures 3-9 months Kwon CH , et al. (2006)
Seizure Seizures Abnormal Electroencephalogram/electromyogram (eeg/emg) 3-9 months Kwon CH , et al. (2006)
Sensory NA Not reported NA NA Takeuchi K , et al. (2013)
Sensory Startle response: acoustic stimulus Increased Acoustic startle reflex test 6 weeks Kwon CH , et al. (2006)
Sensory Sensorimotor gating Abnormal Prepulse inhibition 6 weeks Kwon CH , et al. (2006)
Sensory Olfaction No change Buried food test Unreported Kwon CH , et al. (2006)
Social behavior NA Not reported NA NA Takeuchi K , et al. (2013)
Social behavior Social transmission of food preference Decreased Reciprocal social interaction test Unreported Kwon CH , et al. (2006)
Social behavior Social interaction Decreased Reciprocal social interaction test Unreported Kwon CH , et al. (2006)
Social behavior Social interaction Decreased Reciprocal social interaction test Unreported Kwon CH , et al. (2006)
Social behavior Social approach Decreased Three-chamber social approach test Unreported Kwon CH , et al. (2006)
Social behavior Nest building behavior Decreased Nest building assay Unreported Kwon CH , et al. (2006)
Social behavior Inanimate object preference No change Three-chamber social approach test Unreported Kwon CH , et al. (2006)
Communications NA Not reported NA NA Takeuchi K , et al. (2013)
Communications NA Not reported NA NA Kwon CH , et al. (2006)
Developmental profile NA Not reported NA NA Takeuchi K , et al. (2013)
Developmental profile General characteristics No change General observations 4-5 weeks Kwon CH , et al. (2006)
Emotion NA Not reported NA NA Takeuchi K , et al. (2013)
Emotion Anxiety No change Elevated plus maze test Unreported Kwon CH , et al. (2006)
Emotion Anxiety Increased Open field test Unreported Kwon CH , et al. (2006)
Emotion Anxiety Increased Light-dark exploration test Unreported Kwon CH , et al. (2006)
Immune response NA Not reported NA NA Takeuchi K , et al. (2013)
Immune response NA Not reported NA NA Kwon CH , et al. (2006)
Learning & memory NA Not reported NA NA Takeuchi K , et al. (2013)
Learning & memory Spatial reference memory Decreased Morris water maze test Unreported Kwon CH , et al. (2006)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test Unreported Kwon CH , et al. (2006)
Maternal behavior NA Not reported NA NA Takeuchi K , et al. (2013)
Maternal behavior Nursing/lactation Abnormal Survival analysis Unreported Kwon CH , et al. (2006)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry 8 weeks Takeuchi K , et al. (2013)
Molecular profile Protein modification process Increased Immunohistochemistry 2 months Kwon CH , et al. (2006)

M_PTEN_1_CKO_HM_RAPAMYCIN-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Pten CKO mice with loss of PTEN from cerebellar,hippocampal and cortical neurons were injected with rapamycin (10mg/kg) or vehicle ( 4% ethanol, 5% Tween80 and 5% PEG400) for 5 consecutive days per week at 5-6 weeks of age (i.p., preventative paradigm).Treatment went on for 4 weeks.This concentration of Rapamycin inhibits mTORC1 signaling in the brain.

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Zhou J , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Zhou J , et al. (2009)
Motor phenotype General locomotor activity No adverse effect Open field test 9 weeks Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Restored Immunohistochemistry 10 weeks Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Restored Immunohistochemistry 10 weeks Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Ameliorated Immunohistochemistry 10 weeks Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Restored Immunohistochemistry 10 weeks Zhou J , et al. (2009)
Neurophysiology NA Not reported NA NA Zhou J , et al. (2009)
Repetitive behavior NA Not reported NA NA Zhou J , et al. (2009)
Seizure NA Not reported NA NA Zhou J , et al. (2009)
Sensory NA Not reported NA NA Zhou J , et al. (2009)
Social behavior NA Not reported NA NA Zhou J , et al. (2009)
Communications NA Not reported NA NA Zhou J , et al. (2009)
Developmental profile Size/growth Side effect Body weight measurement 10 weeks Zhou J , et al. (2009)
Emotion Anxiety Ameliorated Open field test 9 weeks Zhou J , et al. (2009)
Immune response NA Not reported NA NA Zhou J , et al. (2009)
Learning & memory NA Not reported NA NA Zhou J , et al. (2009)
Maternal behavior NA Not reported NA NA Zhou J , et al. (2009)
Molecular profile NA Not reported NA NA Zhou J , et al. (2009)

M_PTEN_1_CKO_HM_RAPAMYCIN-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

Pten CKO mice with loss of PTEN from cerebellar,hippocampal and cortical neurons were injected were injected with rapamycin (10mg/kg) or vehicle ( 4% ethanol, 5% Tween80 and 5% PEG400) for 5 consecutive days at 10-12 weeks of age ( i.p., reversal paradigm). Treatment went on for 4-6 weeks. This concentration of Rapamycin inhibits mTORC1 signaling in the brain.

Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Zhou J , et al. (2009)
Circadian sleep/wake cycle NA Not reported NA NA Zhou J , et al. (2009)
Motor phenotype NA Not reported NA NA Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Restored Immunohistochemistry 3.5 -4.5 months Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Ameliorated Immunohistochemistry 3.5 -4.5 months Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Ameliorated Immunohistochemistry 3.5 -4.5 months Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Restored Immunohistochemistry 2.5 months Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Ameliorated Golgi-cox staining 3.5 -4.5 months Zhou J , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture Refractory Immunohistochemistry 3.5 -4.5 months Zhou J , et al. (2009)
Neurophysiology NA Not reported NA NA Zhou J , et al. (2009)
Repetitive behavior NA Not reported NA NA Zhou J , et al. (2009)
Seizure Seizures Ameliorated Electroencephalogram/electromyogram (eeg/emg) Unreported Zhou J , et al. (2009)
Sensory NA Not reported NA NA Zhou J , et al. (2009)
Social behavior NA Not reported NA NA Zhou J , et al. (2009)
Communications NA Not reported NA NA Zhou J , et al. (2009)
Developmental profile NA Not reported NA NA Zhou J , et al. (2009)
Emotion NA Not reported NA NA Zhou J , et al. (2009)
Immune response NA Not reported NA NA Zhou J , et al. (2009)
Learning & memory NA Not reported NA NA Zhou J , et al. (2009)
Maternal behavior NA Not reported NA NA Zhou J , et al. (2009)
Molecular profile Protein modification process Side effect Western blot 3.5 -4.5 months Zhou J , et al. (2009)

M_PTEN_20_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Mice with loxp sites flanking exons 4 and 5 in both alleles of Pten were crossed with Camk2a-Cre heterozygous mice to generate mice with Pten deleted in selectively in the forebrain; M_PTEN_1_CKO_HM; M_PTEN_10_CKO_HM; M_PTEN_12_CKO_HM; M_PTEN_9_CKO_HM

Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: Kwon et al, Nat Gen, 2001
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA ()
Physiological parameters NA Not reported NA NA Chen CJ , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA Chen CJ , et al. (2019)
Motor phenotype General locomotor activity: ambulatory activity Increased Open field test 1.7 months ()
Motor phenotype NA Not reported NA NA Chen CJ , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Abnormal Immunohistochemistry 1.8 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Measurement of tissue weight 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents Increased Whole-cell voltage clamp 1.7 months ()
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No change Whole-cell voltage clamp 1.7 months ()
Neurophysiology Electroencephalogram (eeg) signature Decreased Electroencephalogram (eeg) 1.7 months ()
Neurophysiology Action potential property: half-width No change Whole-cell voltage clamp 1.7 months ()
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents No change Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Increased Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No change Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No change Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Mitochondrial activity No change Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Epsp-spike relationship Increased Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Repetitive behavior NA Not reported NA NA ()
Repetitive behavior NA Not reported NA NA Chen CJ , et al. (2019)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy No change Whole-cell patch clamp 1.7 months ()
Seizure Seizures Increased Observation of seizures 5-7 weeks Chen CJ , et al. (2019)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Increased Electroencephalogram (eeg) 5-7 weeks Chen CJ , et al. (2019)
Sensory NA Not reported NA NA ()
Sensory Pain or nociception No change Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social interaction: with juveniles Decreased Reciprocal social interaction test 1.7 months ()
Social behavior Social memory Decreased Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social interaction Decreased Reciprocal social interaction test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Communications NA Not reported NA NA ()
Communications NA Not reported NA NA Chen CJ , et al. (2019)
Developmental profile NA Not reported NA NA ()
Developmental profile Mortality/lethality Increased Kaplan-meier survival curve 5-7 weeks Chen CJ , et al. (2019)
Emotion Anxiety No change Elevated plus maze test 1.7 months ()
Emotion Anxiety Increased Open field test 1.7 months ()
Emotion NA Not reported NA NA Chen CJ , et al. (2019)
Immune response NA Not reported NA NA ()
Immune response NA Not reported NA NA Chen CJ , et al. (2019)
Learning & memory Object recognition memory No change Novel object recognition test 1.7 months ()
Learning & memory Object recognition memory Decreased Novel object recognition test 5-7 weeks Chen CJ , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of context Decreased Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Learning & memory Cognitive flexibility Decreased T-maze test 5-7 weeks Chen CJ , et al. (2019)
Maternal behavior NA Not reported NA NA ()
Maternal behavior NA Not reported NA NA Chen CJ , et al. (2019)
Molecular profile NA Not reported NA NA ()
Molecular profile Signaling: mtor pathway Increased Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Protein phosphorylation Increased Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Mitochondrial biogenesis No change Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Metabolite levels: neurometabolites Increased Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)

M_PTEN_20_CKO_HM_INTERNEURON

Model Type: RESCUE-Biological
Model Genotype: Homozygous

Mutation:

P1-3 neonatal Pten conditional KO mice were injected bilaterally into the prefrontal cortex with donor cells obtained from E13.5 mice MGE expressing green fluorescent protein. Controls were injected with the acellular vehicle. Seven weeks were allowed for the transplanted MGE cells to differentiate and mature into interneurons.

Allele Type: Conditional knockout
Strain of Origin: CD1
Genetic Background: CD-1*C57Bl6/J

Es cell line: Not Specified
Model Source: Suzuki et al., 2001 (Pten^flox); Xu Tam & Anderson 2008 (Nkx2.1-Cre); Ai14 Cre-reporter (Madisen et al., 2010)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA ()
Circadian sleep/wake cycle NA Not reported NA NA ()
Motor phenotype General locomotor activity: ambulatory activity Refractory Open field test 1.7 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Side effect Immunohistochemistry 1.8 months ()
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents Side effect Whole-cell voltage clamp 1.7 months ()
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No adverse effect Whole-cell voltage clamp 1.7 months ()
Neurophysiology Electroencephalogram (eeg) signature Refractory Electroencephalogram (eeg) 1.7 months ()
Neurophysiology Action potential property: half-width Side effect Whole-cell voltage clamp 1.7 months ()
Repetitive behavior NA Not reported NA NA ()
Seizure NA Not reported NA NA ()
Sensory NA Not reported NA NA ()
Social behavior Social interaction: with juveniles Restored Reciprocal social interaction test 1.7 months ()
Communications NA Not reported NA NA ()
Developmental profile NA Not reported NA NA ()
Emotion Anxiety Refractory Open field test 1.7 months ()
Emotion Anxiety No adverse effect Elevated plus maze test 1.7 months ()
Immune response NA Not reported NA NA ()
Learning & memory Object recognition memory No adverse effect Novel object recognition test 1.7 months ()
Maternal behavior NA Not reported NA NA ()
Molecular profile NA Not reported NA NA ()

M_PTEN_20_CKO_HM_RICTOR-ASO

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Pten CKO mice (M_PTEN_20_CKO_HM) were administered short, synthetic, single-stranded antisense oligonucleotides (ASOs) to target rictor the obligatory component of mTORC2, via a single intracerebroventricular (ICV) injection at 4 weeks.

Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: Kwon et al, Nat Gen, 2001
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Chen CJ , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Chen CJ , et al. (2019)
Motor phenotype NA Not reported NA NA Chen CJ , et al. (2019)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Chen CJ , et al. (2019)
Neurophysiology NA Not reported NA NA Chen CJ , et al. (2019)
Repetitive behavior NA Not reported NA NA Chen CJ , et al. (2019)
Seizure Seizures Ameliorated Observation of seizures 5-7 weeks Chen CJ , et al. (2019)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Ameliorated Electroencephalogram (eeg) 5-7 weeks Chen CJ , et al. (2019)
Sensory NA Not reported NA NA Chen CJ , et al. (2019)
Social behavior Social memory Restored Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Communications NA Not reported NA NA Chen CJ , et al. (2019)
Developmental profile NA Not reported NA NA Chen CJ , et al. (2019)
Emotion NA Not reported NA NA Chen CJ , et al. (2019)
Immune response NA Not reported NA NA Chen CJ , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of context Restored Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Learning & memory Cognitive flexibility Restored T-maze test 5-7 weeks Chen CJ , et al. (2019)
Maternal behavior NA Not reported NA NA Chen CJ , et al. (2019)
Molecular profile Signaling: mtor pathway Ameliorated Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Protein phosphorylation Restored Western blot 5-7 weeks Chen CJ , et al. (2019)

M_PTEN_20_CKO_HM_RICTOR-CKO

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Mice with loxp sites flanking exon 5 in both alleles of Pten and exon 3 of both alleles of Rictor were crossed with Camk2a-Cre heterozygous mice to generate mice with Pten and Rictor selectively deleted in the forebrain.

Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: Huang W, et al, Nat Neurosci, 2013
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Chen CJ , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Chen CJ , et al. (2019)
Motor phenotype NA Not reported NA NA Chen CJ , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Refractory Measurement of tissue weight 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Restored Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No adverse effect Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Mitochondrial activity No adverse effect Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Epsp-spike relationship Restored Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Repetitive behavior NA Not reported NA NA Chen CJ , et al. (2019)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Refractory Electroencephalogram (eeg) 5-7 weeks Chen CJ , et al. (2019)
Sensory Pain or nociception No adverse effect Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social memory Restored Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social interaction Restored Reciprocal social interaction test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social approach No adverse effect Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Communications NA Not reported NA NA Chen CJ , et al. (2019)
Developmental profile Mortality/lethality Ameliorated Kaplan-meier survival curve 5-7 weeks Chen CJ , et al. (2019)
Emotion NA Not reported NA NA Chen CJ , et al. (2019)
Immune response NA Not reported NA NA Chen CJ , et al. (2019)
Learning & memory Object recognition memory Restored Novel object recognition test 5-7 weeks Chen CJ , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of context Restored Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Learning & memory Cognitive flexibility Restored T-maze test 5-7 weeks Chen CJ , et al. (2019)
Maternal behavior NA Not reported NA NA Chen CJ , et al. (2019)
Molecular profile Signaling: mtor pathway Ameliorated Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Protein phosphorylation Restored Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Mitochondrial biogenesis No adverse effect Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Metabolite levels: neurometabolites Restored Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)

M_PTEN_20_CKO_HM_RPTOR-CKO

Model Type: RESCUE-Genetic
Model Genotype: Homozygous

Mutation:

Mice with loxp sites flanking exon 5 in both alleles of Pten and exon 6 of both alleles of Rptor were crossed with Camk2a-Cre heterozygous mice to generate mice with Pten and Rptor selectively deleted in the forebrain.

Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: Jackson Laboratory (stock no. 013188).
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Chen CJ , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Chen CJ , et al. (2019)
Motor phenotype NA Not reported NA NA Chen CJ , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Restored Measurement of tissue weight 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Refractory Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No adverse effect Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Mitochondrial activity No adverse effect Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)
Neurophysiology Epsp-spike relationship Refractory Whole-cell patch clamp 5-7 weeks Chen CJ , et al. (2019)
Repetitive behavior NA Not reported NA NA Chen CJ , et al. (2019)
Seizure Electroencephalogram (eeg): signature of seizure/epilepsy Ameliorated Electroencephalogram (eeg) 5-7 weeks Chen CJ , et al. (2019)
Sensory Pain or nociception No adverse effect Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social memory Refractory Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social interaction Refractory Reciprocal social interaction test 5-7 weeks Chen CJ , et al. (2019)
Social behavior Social approach No adverse effect Three-chamber social approach test 5-7 weeks Chen CJ , et al. (2019)
Communications NA Not reported NA NA Chen CJ , et al. (2019)
Developmental profile Mortality/lethality Refractory Kaplan-meier survival curve 5-7 weeks Chen CJ , et al. (2019)
Emotion NA Not reported NA NA Chen CJ , et al. (2019)
Immune response NA Not reported NA NA Chen CJ , et al. (2019)
Learning & memory Cued or contextual fear conditioning: memory of context Refractory Fear conditioning test 5-7 weeks Chen CJ , et al. (2019)
Learning & memory Cognitive flexibility Refractory T-maze test 5-7 weeks Chen CJ , et al. (2019)
Maternal behavior NA Not reported NA NA Chen CJ , et al. (2019)
Molecular profile Signaling: mtor pathway Ameliorated Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Protein phosphorylation Refractory Western blot 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Mitochondrial biogenesis No adverse effect Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)
Molecular profile Metabolite levels: neurometabolites Refractory Comprehensive metabolic evaluation 5-7 weeks Chen CJ , et al. (2019)

M_PTEN_2_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exon 5 of the Pten gene , that encodes the phosphatase domain, using Nse-cre (or Enolas2-cre) in neurons of the cortex, hippocampus and cerebellum

Allele Type: Conditional loss-of-function
Strain of Origin: BALB/c
Genetic Background: C57BL/6

Es cell line: 129S4/SvJae
Model Source: Not specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Satiety response No change Food intake measurements 5-6 months Cabral-Costa JV , et al. (2018)
Physiological parameters NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Physiological parameters Oxidative stress: systemic Increased Mitochondrial respiratory chain enzyme analysis 5-6 months Napoli E , et al. (2012)
Physiological parameters NA Not reported NA NA Napoli E , et al. (2012)
Circadian sleep/wake cycle NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Napoli E , et al. (2012)
Motor phenotype Swimming ability No change Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Elevated plus maze test 5-6 months Cabral-Costa JV , et al. (2018)
Motor phenotype General locomotor activity No change Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Motor phenotype NA Not reported NA NA Napoli E , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: nmda receptors No change Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: ampa receptors No change Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology No change Measurement of tissue weight 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology No change Measurement of tissue weight 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Measurement of tissue weight 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Measurement of tissue weight 5-7 months Napoli E , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Measurement of tissue weight 5-7 months Napoli E , et al. (2012)
Neurophysiology NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Neurophysiology NA Not reported NA NA Napoli E , et al. (2012)
Repetitive behavior NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 8-13 weeks Napoli E , et al. (2012)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 5-7 months Napoli E , et al. (2012)
Seizure NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Seizure NA Not reported NA NA Napoli E , et al. (2012)
Sensory Startle response No change Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Sensory NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Sensory NA Not reported NA NA Napoli E , et al. (2012)
Social behavior NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Social behavior Social interaction No change Three-chamber social approach test 8-13 weeks Napoli E , et al. (2012)
Social behavior Social interaction No change Three-chamber social approach test 8-13 weeks Napoli E , et al. (2012)
Social behavior Social interaction Decreased Three-chamber social approach test 5-7 months Napoli E , et al. (2012)
Social behavior Social interaction Decreased Three-chamber social approach test 5-7 months Napoli E , et al. (2012)
Communications NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Communications NA Not reported NA NA Napoli E , et al. (2012)
Developmental profile Size/growth No change Body weight measurement 5-6 months Cabral-Costa JV , et al. (2018)
Developmental profile NA Not reported NA NA Napoli E , et al. (2012)
Emotion Anxiety No change Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 5-6 months Cabral-Costa JV , et al. (2018)
Emotion NA Not reported NA NA Napoli E , et al. (2012)
Immune response NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Immune response NA Not reported NA NA Napoli E , et al. (2012)
Learning & memory Spatial working memory No change Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Spatial reference memory No change Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Cued or contextual fear conditioning: passive avoidance Decreased Passive avoidance test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Cognitive flexibility: associative learning No change Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory NA Not reported NA NA Napoli E , et al. (2012)
Maternal behavior NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Maternal behavior NA Not reported NA NA Napoli E , et al. (2012)
Molecular profile Targeted expression Decreased Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Signaling No change Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Signaling Increased Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Protein localization: synapse No change Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Signaling Decreased Western blot 5-7 months Napoli E , et al. (2012)
Molecular profile Protein expression level evidence No change Western blot 4-29 weeks Napoli E , et al. (2012)
Molecular profile Protein expression level evidence No change Western blot 4-6 weeks Napoli E , et al. (2012)
Molecular profile Protein expression level evidence No change Western blot 4-29 weeks Napoli E , et al. (2012)
Molecular profile Protein expression level evidence No change Western blot 8-13 weeks Napoli E , et al. (2012)
Molecular profile Protein expression level evidence Increased Western blot 5-7 months Napoli E , et al. (2012)
Molecular profile Protein expression level evidence Decreased Western blot 5-7 months Napoli E , et al. (2012)
Molecular profile Protein expression level evidence Decreased Western blot 4-29 weeks Napoli E , et al. (2012)
Molecular profile Mitochondrial dna replication Increased Quantitative pcr (qrt-pcr) 8-13 weeks Napoli E , et al. (2012)
Molecular profile Mitochondrial biogenesis No change Mitochondrial respiratory chain enzyme analysis 8-13 weeks Napoli E , et al. (2012)
Molecular profile Mitochondrial biogenesis No change Mitochondrial respiratory chain enzyme analysis 4-6 weeks Napoli E , et al. (2012)
Molecular profile Enzyme activity No change Mitochondrial respiratory chain enzyme analysis 4-29 weeks Napoli E , et al. (2012)
Molecular profile Enzyme activity Decreased Mitochondrial respiratory chain enzyme analysis 5-7 months Napoli E , et al. (2012)

M_PTEN_2_CKO_HT_FASTING

Model Type: RESCUE-Dietary
Model Genotype: Heterozygous

Mutation:

Male Pten heterozygous CKO, with loss of Pten from neural tissue, were subjected to long-term intermittent-fasting, consisting of daily alternations of ad limitum food followed by a day of complete fasting, starting when animals were 3-4 months old and continued for 60 days.

Allele Type: Multifactorial
Strain of Origin: -
Genetic Background: C57BL/6J

Es cell line: -
Model Source: Not specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Satiety response Side effect Food intake measurements 5-6 months Cabral-Costa JV , et al. (2018)
Physiological parameters NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Circadian sleep/wake cycle NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Motor phenotype Swimming ability No adverse effect Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Elevated plus maze test 5-6 months Cabral-Costa JV , et al. (2018)
Motor phenotype General locomotor activity No adverse effect Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: nmda receptors No adverse effect Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: ampa receptors No adverse effect Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology No adverse effect Measurement of tissue weight 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cerebellar morphology No adverse effect Measurement of tissue weight 5-6 months Cabral-Costa JV , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Refractory Measurement of tissue weight 5-6 months Cabral-Costa JV , et al. (2018)
Neurophysiology NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Repetitive behavior NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Seizure NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Sensory Startle response Side effect Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Sensory NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Social behavior NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Communications NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Developmental profile Size/growth Side effect Body weight measurement 5-6 months Cabral-Costa JV , et al. (2018)
Emotion Anxiety Side effect Open field test 5-6 months Cabral-Costa JV , et al. (2018)
Emotion Anxiety Side effect Elevated plus maze test 5-6 months Cabral-Costa JV , et al. (2018)
Immune response NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Learning & memory Spatial working memory No adverse effect Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Spatial reference memory No adverse effect Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Object recognition memory No adverse effect Novel object recognition test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Cued or contextual fear conditioning: passive avoidance Restored Passive avoidance test 5-6 months Cabral-Costa JV , et al. (2018)
Learning & memory Cognitive flexibility: associative learning No adverse effect Morris water maze test 5-6 months Cabral-Costa JV , et al. (2018)
Maternal behavior NA Not reported NA NA Cabral-Costa JV , et al. (2018)
Molecular profile Targeted expression Refractory Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Signaling Restored Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Signaling No adverse effect Western blot 5-6 months Cabral-Costa JV , et al. (2018)
Molecular profile Protein localization: synapse No adverse effect Western blot 5-6 months Cabral-Costa JV , et al. (2018)

M_PTEN_3_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 4-5 of the Pten gene using Nse-cre, authors in PMID 23487788 (Takeuchi K et al 2013) specifically show loss of Pten in granule cells of dentate gyrus and pyramidal neurons of hippocampal CA3 and a subset of postmitotic neruons in the cortex. Same CKOs produced in PMID:16675393

Allele Type: Conditional (knockout)
Strain of Origin: Not specified
Genetic Background: C57BL/6

Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Histology 5 months Takeuchi K , et al. (2013)
Neurophysiology Synaptic transmission No change Whole-cell patch clamp 8-30 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic transmission No change Whole-cell patch clamp 8-20 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic transmission Increased Whole-cell patch clamp 3.5-5 months Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity No change Whole-cell patch clamp 8-12 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity No change Whole-cell patch clamp 8-20 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Increased Whole-cell patch clamp 8-12 weeks Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Decreased Whole-cell patch clamp 4-5months Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Decreased Whole-cell patch clamp 2-7.5 months Takeuchi K , et al. (2013)
Neurophysiology Synaptic plasticity Decreased Whole-cell patch clamp 3.5-7.5 months Takeuchi K , et al. (2013)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp 8-30 weeks Takeuchi K , et al. (2013)
Neurophysiology Presynaptic function: paired-pulse facilitation Decreased Whole-cell patch clamp 3.5-5 months Takeuchi K , et al. (2013)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry 8 weeks Takeuchi K , et al. (2013)

M_PTEN_4_KI_M3M4_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

M3M4 missense double mutations were targeted into the Pten exon 7, which contains the NLS-like sequence.

Allele Type: Targeted (knockin)
Strain of Origin: CD1
Genetic Background: CD1

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Frazier TW , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Frazier TW , et al. (2014)
Motor phenotype NA Not reported NA NA Frazier TW , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Myelination Increased Immunohistochemistry 6 weeks Frazier TW , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Increased Immunohistochemistry 6 weeks Frazier TW , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness No change Immunohistochemistry 6 weeks Frazier TW , et al. (2014)
Neurophysiology NA Not reported NA NA Frazier TW , et al. (2014)
Repetitive behavior NA Not reported NA NA Frazier TW , et al. (2014)
Seizure NA Not reported NA NA Frazier TW , et al. (2014)
Sensory NA Not reported NA NA Frazier TW , et al. (2014)
Social behavior NA Not reported NA NA Frazier TW , et al. (2014)
Communications NA Not reported NA NA Frazier TW , et al. (2014)
Developmental profile NA Not reported NA NA Frazier TW , et al. (2014)
Emotion NA Not reported NA NA Frazier TW , et al. (2014)
Immune response NA Not reported NA NA Frazier TW , et al. (2014)
Learning & memory NA Not reported NA NA Frazier TW , et al. (2014)
Maternal behavior NA Not reported NA NA Frazier TW , et al. (2014)
Molecular profile Gene expression Abnormal Rna sequencing 6 weeks Frazier TW , et al. (2014)

M_PTEN_5_KI_M3M4_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

M3M4 missense double mutations were targeted into the Pten exon 7, which contains the NLS-like sequence.

Allele Type: Targeted (knockin)
Strain of Origin: CD1
Genetic Background: CD1

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Frazier TW , et al. (2014)
Circadian sleep/wake cycle NA Not reported NA NA Frazier TW , et al. (2014)
Motor phenotype NA Not reported NA NA Frazier TW , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Myelination Increased Immunohistochemistry 6 weeks Frazier TW , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Increased Immunohistochemistry 6 weeks Frazier TW , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness No change Immunohistochemistry 6 weeks Frazier TW , et al. (2014)
Neurophysiology NA Not reported NA NA Frazier TW , et al. (2014)
Repetitive behavior NA Not reported NA NA Frazier TW , et al. (2014)
Seizure NA Not reported NA NA Frazier TW , et al. (2014)
Sensory NA Not reported NA NA Frazier TW , et al. (2014)
Social behavior NA Not reported NA NA Frazier TW , et al. (2014)
Communications NA Not reported NA NA Frazier TW , et al. (2014)
Developmental profile NA Not reported NA NA Frazier TW , et al. (2014)
Emotion NA Not reported NA NA Frazier TW , et al. (2014)
Immune response NA Not reported NA NA Frazier TW , et al. (2014)
Learning & memory NA Not reported NA NA Frazier TW , et al. (2014)
Maternal behavior NA Not reported NA NA Frazier TW , et al. (2014)
Molecular profile NA Not reported NA NA Frazier TW , et al. (2014)

M_PTEN_6_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Deletion of gene sequence from BglII site in exon 5 to the next BglII site 2.0 kb downstream.

Allele Type: Targeted (knockout)
Strain of Origin: 129Sv/J
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Physiological parameters NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Circadian sleep/wake cycle NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle Increased Running wheel test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Circadian sleep/wake cycle Locomotor activity in diurnal cycle Decreased Running wheel test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Circadian sleep/wake cycle Circadian rhythms: timing/phases of locomotor activity No change Running wheel test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Circadian sleep/wake cycle Adaptation to dark phase No change Running wheel test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Circadian sleep/wake cycle Adaptation to dark phase Decreased Running wheel test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Motor phenotype NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial number No change Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial number Increased Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial morphology Increased Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Microglial morphology Increased Immunohistochemistry 2 weeks Xu ZX et al. (2020)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased General observations 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Measurement of tissue weight 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Neurophysiology NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Neurophysiology NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Repetitive behavior Self grooming: perseveration Increased Resident-intruder test 11-16 weeks Clipperton-Allen AE and Page DT (2015)
Repetitive behavior Repetitive digging Increased Resident-intruder test 11-16 weeks Clipperton-Allen AE and Page DT (2015)
Repetitive behavior Repetitive digging Increased Marble-burying test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Repetitive behavior Repetitive digging No change Marble-burying test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Seizure NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Seizure NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Sensory NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Sensory Pain or nociception No change Hot plate test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social interaction Decreased Resident-intruder test 11-16 weeks Clipperton-Allen AE and Page DT (2015)
Social behavior Rearing behavior Increased Resident-intruder test 11-16 weeks Clipperton-Allen AE and Page DT (2015)
Social behavior Aggression Decreased Resident-intruder test 11-16 weeks Clipperton-Allen AE and Page DT (2015)
Social behavior Social memory Decreased Three-chamber social approach test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social interaction No change Reciprocal social interaction test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social habituation Decreased Reciprocal social interaction test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social habituation No change Reciprocal social interaction test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social dishabituation No change Reciprocal social interaction test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social approach Decreased Three-chamber social approach test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Communications NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Communications NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Developmental profile NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Developmental profile Size/growth No change General observations 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Exploratory activity Increased Resident-intruder test 11-16 weeks Clipperton-Allen AE and Page DT (2015)
Emotion Depression Increased Tail suspension test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Depression Increased Forced swim test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Depression No change Tail suspension test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Depression No change Forced swim test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Anxiety Decreased Open field test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Anxiety Decreased Light-dark exploration test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Anxiety No change Open field test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Emotion Anxiety No change Light-dark exploration test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Immune response NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Immune response NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Learning & memory NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Learning & memory Cued or contextual fear conditioning: trace fear conditioning No change Fear conditioning test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Learning & memory Cued or contextual fear conditioning: trace fear conditioning Decreased Fear conditioning test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Learning & memory Cued or contextual fear conditioning: memory of context Decreased Fear conditioning test 7-20 weeks Clipperton-Allen AE and Page DT (2014)
Maternal behavior NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Maternal behavior NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Molecular profile NA Not reported NA NA Clipperton-Allen AE and Page DT (2015)
Molecular profile NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)

M_PTEN_7_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 5 of the Pten gene using endogenous Slc6a3 (Dopamine transporter, DAT)-cre, in dopaminergic neurons

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Circadian sleep/wake cycle NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Motor phenotype General locomotor activity: ambulatory activity Abnormal Three-chamber social approach test 7-15 weeks Clipperton-Allen AE and Page DT (2014)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test 7-15 weeks Clipperton-Allen AE and Page DT (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Neurophysiology NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Repetitive behavior NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Seizure NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Sensory NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Social behavior Social memory Decreased Three-chamber social approach test 7-15 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social memory No change Three-chamber social approach test 7-15 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social approach No change Three-chamber social approach test 7-15 weeks Clipperton-Allen AE and Page DT (2014)
Social behavior Social approach Decreased Three-chamber social approach test 7-15 weeks Clipperton-Allen AE and Page DT (2014)
Communications NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Developmental profile NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Emotion NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Immune response NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Learning & memory NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Maternal behavior NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)
Molecular profile NA Not reported NA NA Clipperton-Allen AE and Page DT (2014)

M_PTEN_8_CKO_HM_DG

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exon 5 of the Pten gene using a T2A-cre containing retrovirus injected bilaterally into dentate gyrus at postnatal day 7

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6

Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Williams MR , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Williams MR , et al. (2015)
Motor phenotype NA Not reported NA NA Williams MR , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size Increased Immunohistochemistry 3-4.5 weeks Williams MR , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Fluorescence microscopy 3-4.5 weeks Williams MR , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Increased Fluorescence microscopy 3-4.5 weeks Williams MR , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Increased Fluorescence microscopy 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Synaptic transmission: inhibitory No change Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Synaptic transmission: excitatory Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Neurotransmitter release: quantal parameters Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Neuronal activation Increased Immunohistochemistry 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Network excitability Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Miniature post synaptic current frequency: excitatory Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Miniature post synaptic current amplitude: excitatory Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Ion influx and permeability: calcium Increased Fluorescence microscopy 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Intrinsic membrane properties Abnormal Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Neurophysiology Action potential property: firing rate Increased Whole-cell patch clamp 3-4.5 weeks Williams MR , et al. (2015)
Repetitive behavior NA Not reported NA NA Williams MR , et al. (2015)
Seizure NA Not reported NA NA Williams MR , et al. (2015)
Sensory NA Not reported NA NA Williams MR , et al. (2015)
Social behavior NA Not reported NA NA Williams MR , et al. (2015)
Communications NA Not reported NA NA Williams MR , et al. (2015)
Developmental profile NA Not reported NA NA Williams MR , et al. (2015)
Emotion NA Not reported NA NA Williams MR , et al. (2015)
Immune response NA Not reported NA NA Williams MR , et al. (2015)
Learning & memory NA Not reported NA NA Williams MR , et al. (2015)
Maternal behavior NA Not reported NA NA Williams MR , et al. (2015)
Molecular profile Targeted expression Decreased Immunohistochemistry 2 weeks Williams MR , et al. (2015)

M_PTEN_9_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 4-5 of the PTEN gene using Nkx2.1-Cre, in the ventricular zone of the medical ganglionic eminence (MGE) that gives rise to interneurons starting E9.5. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype General locomotor activity No change Open field test NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size Increased Immunohistochemistry NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry P0, p8, 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation Decreased NA 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation Decreased NA E15.5, 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Histology 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Anatomical projections and connectivity Increased Immunohistochemistry 4 weeks Vogt D , et al. (2015)
Neurophysiology Spontaneous post synaptic events: inhibitory currents Increased Whole-cell patch clamp 4 weeks Vogt D , et al. (2015)
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents No change Whole-cell patch clamp 4 weeks Vogt D , et al. (2015)
Neurophysiology Electroencephalogram (eeg) signature Increased Electroencephalogram (eeg) 4 weeks Vogt D , et al. (2015)
Neurophysiology Apoptosis: brain cells Increased Expression of cleaved caspase-3 (cc3) E17.5, p0 Vogt D , et al. (2015)
Neurophysiology Apoptosis: brain cells Increased Expression of cleaved caspase-3 (cc3) P0 Vogt D , et al. (2015)
Neurophysiology Apoptosis: brain cells Increased Cell counting P0 Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior Social interaction Decreased Reciprocal social interaction test P30 Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile Size/growth Decreased Body weight measurement 4 weeks Vogt D , et al. (2015)
Developmental profile Mortality/lethality No change General observations NA Vogt D , et al. (2015)
Emotion Anxiety No change Open field test NA Vogt D , et al. (2015)
Emotion Anxiety No change Elevated plus maze test NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory Object recognition memory Decreased Novel object recognition test NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile Protein phosphorylation Increased Western blot E13.5 Vogt D , et al. (2015)
Molecular profile Cell proliferation No change Phospho-histone 3 expression NA Vogt D , et al. (2015)
Molecular profile Cell proliferation No change Edu incorporation NA Vogt D , et al. (2015)

M_PTEN_9_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exons 4-5 of the PTEN gene using Nkx2.1-Cre in the ventricular zone of the medical ganglionic eminence (MGE) that gives rise to interneurons starting E9.5. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.

Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters NA Not reported NA NA Vogt D , et al. (2015)
Circadian sleep/wake cycle NA Not reported NA NA Vogt D , et al. (2015)
Motor phenotype NA Not reported NA NA Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation No change NA 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Histology 4 weeks Vogt D , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture Anatomical projections and connectivity No change Immunohistochemistry 4 weeks Vogt D , et al. (2015)
Neurophysiology Spontaneous post synaptic events: inhibitory currents No change Whole-cell patch clamp 4 weeks Vogt D , et al. (2015)
Repetitive behavior NA Not reported NA NA Vogt D , et al. (2015)
Seizure NA Not reported NA NA Vogt D , et al. (2015)
Sensory NA Not reported NA NA Vogt D , et al. (2015)
Social behavior NA Not reported NA NA Vogt D , et al. (2015)
Communications NA Not reported NA NA Vogt D , et al. (2015)
Developmental profile Size/growth No change Body weight measurement 4 weeks Vogt D , et al. (2015)
Developmental profile Mortality/lethality No change General observations NA Vogt D , et al. (2015)
Emotion NA Not reported NA NA Vogt D , et al. (2015)
Immune response NA Not reported NA NA Vogt D , et al. (2015)
Learning & memory NA Not reported NA NA Vogt D , et al. (2015)
Maternal behavior NA Not reported NA NA Vogt D , et al. (2015)
Molecular profile NA Not reported NA NA Vogt D , et al. (2015)
Other PTEN Rescue Models(6 Models)
M_PTEN_1_CKO_HM 2 Genetic Pharmaceutical Rapamycin
M_PTEN_2_CKO_HT 1 Genetic Dietary Fasting
M_PTEN_20_CKO_HM 1 Genetic Biological Interneuron
M_PTEN_20_CKO_HM 1 Genetic Genetic Rictor antisense oligonucleotide
M_PTEN_20_CKO_HM 1 Genetic Genetic Rictor conditional knockout
M_PTEN_20_CKO_HM 1 Genetic Genetic Rptor conditional knockout
CNVs associated with PTEN(1 Models)
10q23.31 8 Deletion 15  /  44
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SFARI Gene Update

We are pleased to announce some changes to the ongoing curation of the data in SFARI Gene. In the context of a continued effort to develop the human gene module and its manually curated list of autism risk genes, we are modifying other aspects of the site to focus on the information that is of greatest interest to the research community. The version of SFARI Gene that has been developed until now will be frozen and will remain available as “SFARI Gene Archive”. Please see the announcement for more details.
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