PTEN phosphatase and tensin homolog
Model Species
Mus musculusGene Aliases
2310035O07Rik, A130070J02Rik, AI463227, MMAC1, TEP1Models / Rescue Models
34 / 8Rescue Model
-Model Summary
Mutant mice display abnormal social interaction and exaggerated responses to sensory stimuli.
External Links
Reports related to PTEN (20 Reports)
| # | Type | Title | Author, Year |
|---|---|---|---|
| 1 | Primary | Pten regulates neuronal arborization and social interaction in mice. | Kwon CH , et al. (2006) |
| 2 | Primary | Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. | Zhou J , et al. (2009) |
| 3 | Additional | Allele-specific tumor spectrum in pten knockin mice. | Wang H , et al. (2010) |
| 4 | Additional | Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. | Napoli E , et al. (2012) |
| 5 | Additional | Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism. | Takeuchi K , et al. (2013) |
| 6 | Additional | Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests. | Clipperton-Allen AE and Page DT (2014) |
| 7 | Additional | Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism. | Frazier TW , et al. (2014) |
| 8 | Additional | Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice. | Clipperton-Allen AE and Page DT (2015) |
| 9 | Additional | Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive. | Williams MR , et al. (2015) |
| 10 | Additional | The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. | Vogt D , et al. (2015) |
| 11 | Additional | Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice. | Cupolillo D , et al. (2015) |
| 12 | Additional | Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior. | Smith GD , et al. (2016) |
| 13 | Additional | Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice. | Cabral-Costa JV , et al. (2018) |
| 14 | Additional | PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior. | Snchez-Puelles C , et al. (2019) |
| 15 | Additional | Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. | Chen CJ , et al. (2019) |
| 16 | Additional | Interneuron Transplantation Rescues Social Behavior Deficits Without Restoring Wild-Type Physiology in a Mouse Model of Autism With Excessive Synaptic Inhibition </title> | () |
| 17 | Additional | Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations | Xu ZX et al. (2020) |
| 18 | Additional | Pten haploinsufficiency causes desynchronized growth of brain areas involved in sensory processing | Clipperton-Allen AE et al. (2022) |
| 19 | Additional | Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss | Tariq K et al. (2022) |
| 20 | Additional | - | Zhou X et al. (2022) |
Show all Construct Details
Show all Phenotypic Profiles
M_PTEN_10_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exons 4-5 of of PTEN using Dlxl12b-cre mice, in gabaergic interneurons of the forebrain, by E15.5. Authors report assessments looking into the secondary progenitor cells of the subventricular zone of the subpallium
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | Decreased | Immunohistochemistry | P18 | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Increased | Immunohistochemistry | P18 | Vogt D , et al. (2015) |
| Neurophysiology | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | Mortality/lethality | Increased | Survival analysis | P18 | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
M_PTEN_10_CKO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Conditional heterozygous deletion of exons 4-5 of of PTEN using Dlxl12b-cre mice, in gabaergic neurons of the forebrain, by E15.5. Authors report assessments looking into the secondary progenitor cells of the subventricular zone of the subpallium
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal specification | No change | NA | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | No change | Immunohistochemistry | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
M_PTEN_11_CKO_HM_SSTN
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exons 4 - 5 using SST-IRES-Cre, in postmitotic somatostatin expressing cells as they leave the medial ganglionic eminence. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1* C56BL/6
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | No change | Immunohistochemistry | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | No change | Immunohistochemistry | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
M_PTEN_11_CKO_HT_SSTN
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Conditional heterozygous deletion of exons 4 - 5 using SST-IRES-Cre, in postmitotic somatostatin expressing cells as they leave the medial ganglionic eminence. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal specification | No change | NA | P18 | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | No change | Immunohistochemistry | P18 | Vogt D , et al. (2015) |
| Neurophysiology | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
M_PTEN_12_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
In this cell transplant based model, cells from with a homozygous loss of Pten using Dlxl12b-Cre+ were extracted from E12.5 embryos, then transplanted to wild type recipient mice at P1 to see how complete loss of Pten from the secondary progenitors in the subventricular zone (SVZ) of the entire subpallium, affects cell differentiation. The recipient mouse neocortices were then examined 35 days following transplantation.
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Increased | Immunohistochemistry | 35dpt | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Decreased | NA | 35dpt | Vogt D , et al. (2015) |
| Neurophysiology | Intrinsic membrane properties | Decreased | Whole-cell patch clamp | 45dpt | Vogt D , et al. (2015) |
| Neurophysiology | Action potential property: firing rate | No change | Whole-cell patch clamp | 45dpt | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
M_PTEN_12_CKO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
In this cell transplant based model, cells from with a heterozygous loss of Pten using Dlxl12b-Cre+ were extracted from E12.5 embryos, then transplanted to wild type recipient mice at P1 to see howpartial loss of Pten from the secondary progenitors in the subventricular zone (SVZ) of the entire subpallium, affects cell differentiation. he recipient mouse neocortices were then examined 35 days following transplantation.
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | No change | Immunohistochemistry | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Decreased | NA | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
M_PTEN_13_KI_HM
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Partial loss-of-function knockin mice with truncated Pten gene lacking its C-terminal PDZ motif, Pten^tm(Q399stop)amc, were generated by homologous recombination in iTL1 129S6/SvEvBrdTac(129Sv)-derived embryonic stem cells where residues 399 to 403 were truncated. The PDZ-binding domain was deleted by substituting codon 399 (CAA) with a stop codon (TAA), as previously described (Knafo et al. 2016, PMID 26780512). These mice express normal levels of total Pten protein and normal Pten catalytic activity.
Allele Type: LOF Knockin
Strain of Origin: 129S6/SvEvBrdTac(129Sv)
Genetic Background: C57BL/6
Es cell line: 129S6/SvEvBrdTac(129Sv)
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Motor phenotype | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | No change | Electron microscopy | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Post-synaptic density size | No change | Electron microscopy | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology of the amygdala | No change | Stereology | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Stereology | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: ltd | No change | Field potential recordings | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: ltd | Decreased | Field potential recordings | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Repetitive behavior | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Seizure | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Sensory | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Physiological parameters | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Communications | Ultrasonic vocalization: isolation induced | No change | Monitoring ultrasonic vocalizations; | P3-p12 | Snchez-Puelles C , et al. (2019) |
| Developmental profile | Size/growth | No change | Measurement of body weight | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Emotion | Anxiety | No change | Elevated plus maze test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Immune response | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of cue | No change | Fear conditioning test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Maternal behavior | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Molecular profile | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
M_PTEN_14_TG
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Gain-of-function mutant mice with increased Pten copy number (Pten^tg) that overexpress Pten protein were generated by bacterial artificial chromosome (BAC) transgenesis on a C57BL6/CBA genetic background as previously described in Ortega-Molina et al. 2012, PMID 22405073 (gift from the lab of Manuel Serrano, IRB, Barcelona, Spain).
Allele Type: Overexpression
Strain of Origin: -
Genetic Background: C57BL6*CBA
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Motor phenotype | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | Decreased | Electron microscopy | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Post-synaptic density size | No change | Electron microscopy | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Post-synaptic density size | Decreased | Electron microscopy | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology of the amygdala | No change | Cranial computerized tomography (ct) scan | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Decreased | Cranial computerized tomography (ct) scan | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Decreased | Sholl analysis | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Sholl analysis | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Stereology | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: ltd | No change | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: ltd | Increased | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: hippocampal ltp | Decreased | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: amygdalar ltp | Decreased | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Synaptic plasticity: amygdalar ltp | No change | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Neuronal activation following behavioral stimulation | Decreased | Positron emission tomography (pet) imaging | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Neuronal activation | No change | Positron emission tomography (pet) imaging | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Neuronal activation | Decreased | Positron emission tomography (pet) imaging | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Neuronal activation | Increased | Positron emission tomography (pet) imaging | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Intrinsic membrane properties | No change | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Intrinsic membrane properties | Decreased | Whole-cell patch clamp | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Epsp-spike relationship | Decreased | Field potential recordings | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Neurophysiology | Epsp-spike relationship | No change | Field potential recordings | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Repetitive behavior | Self grooming: perseveration | No change | Grooming behavior assessments | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Seizure | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Sensory | Pain or nociception | No change | Foot shock test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Social behavior | Social approach | Increased | Three-chamber social approach test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Physiological parameters | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Communications | Ultrasonic vocalization: isolation induced | Decreased | Monitoring ultrasonic vocalizations; | P3-p12 | Snchez-Puelles C , et al. (2019) |
| Developmental profile | Size/growth | Decreased | Body weight measurement | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Emotion | Habituation to aversive stimuli | No change | Fear conditioning test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Emotion | Exploratory activity | No change | Open field test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Emotion | Anxiety | Decreased | Elevated plus maze test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Immune response | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Spatial working memory | Decreased | Barnes maze test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Spatial reference memory | No change | Barnes maze test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Object recognition memory | No change | Object-place recognition test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of cue | Decreased | Fear conditioning test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Learning & memory | Cognitive flexibility | Decreased | Barnes maze test | 6-12 months | Snchez-Puelles C , et al. (2019) |
| Maternal behavior | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
| Molecular profile | NA | Not reported | NA | NA | Snchez-Puelles C , et al. (2019) |
M_PTEN_17_CKO_HM_PURKINJEN
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 5 of the Pten gene using L7-Cre in Purkinje cells of the cerebellum
Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 2-3 months | Cupolillo D , et al. (2015) |
| Motor phenotype | Motor coordination and balance | Decreased | Accelerating rotarod test | 5-6 months | Cupolillo D , et al. (2015) |
| Motor phenotype | General locomotor activity | No change | Three-chamber social approach test | 4 months | Cupolillo D , et al. (2015) |
| Motor phenotype | General locomotor activity | No change | Open field test | 4 months | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Increased | Cell size measurement | 2 months, 4 months, 9 months | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: purkinje cells | Decreased | Immunohistochemistry | 6 months | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Immunohistochemistry | 2 months, 4 months, 6 months | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Increased | Immunohistochemistry | 2 months, 4 months, 6 months | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cytoskeletal organization: neuronal | Increased | Immunohistochemistry | NA | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology: molecular layer thickness | Increased | Immunostaining | 2months, 4 months | Cupolillo D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Histology | 2-3 months | Cupolillo D , et al. (2015) |
| Neurophysiology | Synaptic transmission: excitatory | Increased | Cell-attached patch clamp | 3-4.5 months | Cupolillo D , et al. (2015) |
| Neurophysiology | Synaptic transmission: excitatory | Increased | Cell-attached patch clamp | 3-4.5 months | Cupolillo D , et al. (2015) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Paired-pulse ratio | 3-4.5 months | Cupolillo D , et al. (2015) |
| Neurophysiology | Presynaptic function: paired-pulse depression (ppd) | Decreased | Whole-cell patch clamp | 3-4.5 months | Cupolillo D , et al. (2015) |
| Neurophysiology | Apoptosis: brain cells | Increased | Expression of cleaved caspase-3 (cc3) | 9 months | Cupolillo D , et al. (2015) |
| Neurophysiology | Action potential property: firing rate | Decreased | Cell-attached patch clamp | 3-4.5 months | Cupolillo D , et al. (2015) |
| Repetitive behavior | Vertical jumping or back flipping | Increased | Observation of repetitive behavior | 3-4months | Cupolillo D , et al. (2015) |
| Repetitive behavior | Self grooming: perseveration | Decreased | Grooming behavior assessments | 3-4 months | Cupolillo D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Social behavior | Social interaction: opposite sex | Decreased | Reciprocal social interaction test | 3-4months | Cupolillo D , et al. (2015) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 3-4months | Cupolillo D , et al. (2015) |
| Social behavior | Social approach | Decreased | Open field test | 3-4months | Cupolillo D , et al. (2015) |
| Physiological parameters | Reproductive function | No change | General observations | Adult | Cupolillo D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Developmental profile | Mortality/lethality | No change | General observations | Adult | Cupolillo D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Learning & memory | Spatial reference memory | No change | Morris water maze test | Adult | Cupolillo D , et al. (2015) |
| Learning & memory | Spatial learning | No change | Morris water maze test | Adult | Cupolillo D , et al. (2015) |
| Learning & memory | Cognitive flexibility | No change | Morris water maze test | Adult | Cupolillo D , et al. (2015) |
| Learning & memory | Cognitive flexibility | No change | Water t-maze test | Adult | Cupolillo D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Cupolillo D , et al. (2015) |
| Molecular profile | Signaling | Increased | Immunohistochemistry | 4 months | Cupolillo D , et al. (2015) |
M_PTEN_18_CKO_HT_SEIZURE
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Multifactorial model, Pten CKO mice, with deletion of exons 4 and 5 using GFAP-cre, authors indicate that the is KO localized to the hippocampal granule cells of the dentate gyrus, by P5. These PTEN het CKO mice were treated with 20mg/kg (in 0.9% saline) of kainate (ip) beginning at P60 (2 months age). At approximately 1 hour following saline (control) or kainate injections, all mice received an ip injection of pentobarbital (20mg/kg) to terminate seizure activity. All behavioral testing was carried out 1 week after seizure induction, only mice that had entered the status epilepticus so that they all fell into the category of highest seizure severity were used in the studies.
Allele Type: Multifactorial
Strain of Origin: 129P2/OlaHsd
Genetic Background: FVB*mixed
Es cell line: E14K
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Motor phenotype | Swimming ability | No change | Morris water maze test | 12-13 weeks | Smith GD , et al. (2016) |
| Motor phenotype | Hyperactivity | Increased | Open field test | 9 weeks | Smith GD , et al. (2016) |
| Motor phenotype | Hyperactivity | Increased | Elevated plus maze test | 9 weeks | Smith GD , et al. (2016) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Neurophysiology | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Repetitive behavior | Self grooming: perseveration | No change | Open field test | 9 weeks | Smith GD , et al. (2016) |
| Repetitive behavior | Repetitive digging | No change | Marble-burying test | 10 weeks | Smith GD , et al. (2016) |
| Repetitive behavior | Circling | No change | Open field test | 9 weeks | Smith GD , et al. (2016) |
| Seizure | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Sensory | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 10 weeks | Smith GD , et al. (2016) |
| Physiological parameters | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Communications | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Developmental profile | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Emotion | Exploratory activity | No change | Three-chamber social approach test | 10 weeks | Smith GD , et al. (2016) |
| Emotion | Anxiety | No change | Open field test | 9 weeks | Smith GD , et al. (2016) |
| Immune response | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Learning & memory | Spatial reference memory | No change | Morris water maze test | 13 weeks | Smith GD , et al. (2016) |
| Learning & memory | Spatial learning | No change | Morris water maze test | 13 weeks | Smith GD , et al. (2016) |
| Learning & memory | Cued or contextual fear conditioning: trace fear conditioning | Increased | Fear conditioning test | 12 weeks | Smith GD , et al. (2016) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 12 weeks | Smith GD , et al. (2016) |
| Maternal behavior | NA | Not reported | NA | NA | Smith GD , et al. (2016) |
| Molecular profile | Protein phosphorylation | No change | Western blot | 14 weeks | Smith GD , et al. (2016) |
| Molecular profile | Protein localization: synapse | No change | Western blot | 14 weeks | Smith GD , et al. (2016) |
| Molecular profile | Protein expression level evidence | No change | Western blot | 14 weeks | Smith GD , et al. (2016) |
M_PTEN_19_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Exon 4 and 5 are floxed by introducing loxP sites in introns 3 and 5, homozygous mice are obtained by breeding heterozygous knockouts following germline transmission of exon4-5 deletion.
Allele Type: -
Strain of Origin: -
Genetic Background: FVB/N *129Sv/Ev* Black swiss
Es cell line: -
Model Source: PMID: 20194734
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Motor phenotype | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Neurophysiology | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Repetitive behavior | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Seizure | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Sensory | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Social behavior | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Physiological parameters | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Communications | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Developmental profile | Mortality/lethality: embryonic | Increased | Survival analysis | E9.5 | Wang H , et al. (2010) |
| Emotion | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Immune response | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Learning & memory | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Maternal behavior | NA | Not reported | NA | NA | Wang H , et al. (2010) |
| Molecular profile | NA | Not reported | NA | NA | Wang H , et al. (2010) |
M_PTEN_1_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exons 4-5 of the Pten gene using Nse-cre, authors in PMID 23487788 (Takeuchi K et al 2013) specifically show loss of Pten in granule cells of dentate gyrus and pyramidal neurons of hippocampal CA3 and a subset of postmitotic neruons in the cortex. Same CKOs produced in PMID:16675393
Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
Es cell line: E14K
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Kwon CH , et al. (2006) |
| Motor phenotype | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Motor phenotype | Motor strength and endurance | No change | Vertical pole test | Unreported | Kwon CH , et al. (2006) |
| Motor phenotype | Motor strength and endurance | No change | Dowel walk test | Unreported | Kwon CH , et al. (2006) |
| Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | Unreported | Kwon CH , et al. (2006) |
| Motor phenotype | General locomotor activity | Abnormal | Open field test | 6 weeks | Kwon CH , et al. (2006) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Abnormal | Histology | 5 months | Takeuchi K , et al. (2013) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Abnormal | Immunohistochemistry | 10.7 months | Kwon CH , et al. (2006) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Abnormal | Immunohistochemistry | 3-9 months | Kwon CH , et al. (2006) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Abnormal | Histology | Unreported | Kwon CH , et al. (2006) |
| Neurophysiology | Synaptic transmission | No change | Whole-cell patch clamp | 8-30 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic transmission | No change | Whole-cell patch clamp | 8-20 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic transmission | Increased | Whole-cell patch clamp | 3.5-5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | No change | Whole-cell patch clamp | 8-12 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | No change | Whole-cell patch clamp | 8-20 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Increased | Whole-cell patch clamp | 8-12 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Decreased | Whole-cell patch clamp | 4-5months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Decreased | Whole-cell patch clamp | 2-7.5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Decreased | Whole-cell patch clamp | 3.5-7.5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell patch clamp | 8-30 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | Decreased | Whole-cell patch clamp | 3.5-5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | NA | Not reported | NA | NA | Kwon CH , et al. (2006) |
| Repetitive behavior | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Repetitive behavior | NA | Not reported | NA | NA | Kwon CH , et al. (2006) |
| Seizure | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Seizure | Seizures | Abnormal | Observation of seizures | 3-9 months | Kwon CH , et al. (2006) |
| Seizure | Seizures | Abnormal | Electroencephalogram/electromyogram (eeg/emg) | 3-9 months | Kwon CH , et al. (2006) |
| Sensory | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Sensory | Startle response: acoustic stimulus | Increased | Acoustic startle reflex test | 6 weeks | Kwon CH , et al. (2006) |
| Sensory | Sensorimotor gating | Abnormal | Prepulse inhibition | 6 weeks | Kwon CH , et al. (2006) |
| Sensory | Olfaction | No change | Buried food test | Unreported | Kwon CH , et al. (2006) |
| Social behavior | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Social behavior | Social transmission of food preference | Decreased | Reciprocal social interaction test | Unreported | Kwon CH , et al. (2006) |
| Social behavior | Social interaction | Decreased | Reciprocal social interaction test | Unreported | Kwon CH , et al. (2006) |
| Social behavior | Social interaction | Decreased | Reciprocal social interaction test | Unreported | Kwon CH , et al. (2006) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | Unreported | Kwon CH , et al. (2006) |
| Social behavior | Nest building behavior | Decreased | Nest building assay | Unreported | Kwon CH , et al. (2006) |
| Social behavior | Inanimate object preference | No change | Three-chamber social approach test | Unreported | Kwon CH , et al. (2006) |
| Physiological parameters | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Physiological parameters | NA | Not reported | NA | NA | Kwon CH , et al. (2006) |
| Communications | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Communications | NA | Not reported | NA | NA | Kwon CH , et al. (2006) |
| Developmental profile | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Developmental profile | General characteristics | No change | General observations | 4-5 weeks | Kwon CH , et al. (2006) |
| Emotion | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Emotion | Anxiety | No change | Elevated plus maze test | Unreported | Kwon CH , et al. (2006) |
| Emotion | Anxiety | Increased | Open field test | Unreported | Kwon CH , et al. (2006) |
| Emotion | Anxiety | Increased | Light-dark exploration test | Unreported | Kwon CH , et al. (2006) |
| Immune response | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Immune response | NA | Not reported | NA | NA | Kwon CH , et al. (2006) |
| Learning & memory | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Learning & memory | Spatial reference memory | Decreased | Morris water maze test | Unreported | Kwon CH , et al. (2006) |
| Learning & memory | Cued or contextual fear conditioning: memory of cue | No change | Fear conditioning test | Unreported | Kwon CH , et al. (2006) |
| Maternal behavior | NA | Not reported | NA | NA | Takeuchi K , et al. (2013) |
| Maternal behavior | Nursing/lactation | Abnormal | Survival analysis | Unreported | Kwon CH , et al. (2006) |
| Molecular profile | Protein expression level evidence | Decreased | Immunohistochemistry | 8 weeks | Takeuchi K , et al. (2013) |
| Molecular profile | Protein modification process | Increased | Immunohistochemistry | 2 months | Kwon CH , et al. (2006) |
M_PTEN_1_CKO_HM_RAPAMYCIN-1
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Pten CKO mice with loss of PTEN from cerebellar,hippocampal and cortical neurons were injected with rapamycin (10mg/kg) or vehicle ( 4% ethanol, 5% Tween80 and 5% PEG400) for 5 consecutive days per week at 5-6 weeks of age (i.p., preventative paradigm).Treatment went on for 4 weeks.This concentration of Rapamycin inhibits mTORC1 signaling in the brain.
Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Motor phenotype | General locomotor activity | No adverse effect | Open field test | 9 weeks | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Immunohistochemistry | 10 weeks | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Restored | Immunohistochemistry | 10 weeks | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Ameliorated | Immunohistochemistry | 10 weeks | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Restored | Immunohistochemistry | 10 weeks | Zhou J , et al. (2009) |
| Neurophysiology | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Repetitive behavior | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Seizure | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Sensory | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Social behavior | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Physiological parameters | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Communications | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Developmental profile | Size/growth | Side effect | Body weight measurement | 10 weeks | Zhou J , et al. (2009) |
| Emotion | Anxiety | Ameliorated | Open field test | 9 weeks | Zhou J , et al. (2009) |
| Immune response | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Learning & memory | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Maternal behavior | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Molecular profile | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
M_PTEN_1_CKO_HM_RAPAMYCIN-2
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
Pten CKO mice with loss of PTEN from cerebellar,hippocampal and cortical neurons were injected were injected with rapamycin (10mg/kg) or vehicle ( 4% ethanol, 5% Tween80 and 5% PEG400) for 5 consecutive days at 10-12 weeks of age ( i.p., reversal paradigm). Treatment went on for 4-6 weeks. This concentration of Rapamycin inhibits mTORC1 signaling in the brain.
Allele Type: Conditional loss-of-function
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Motor phenotype | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Restored | Immunohistochemistry | 3.5 -4.5 months | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | Ameliorated | Immunohistochemistry | 3.5 -4.5 months | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Ameliorated | Immunohistochemistry | 3.5 -4.5 months | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Restored | Immunohistochemistry | 2.5 months | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Ameliorated | Golgi-cox staining | 3.5 -4.5 months | Zhou J , et al. (2009) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | Refractory | Immunohistochemistry | 3.5 -4.5 months | Zhou J , et al. (2009) |
| Neurophysiology | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Repetitive behavior | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Seizure | Seizures | Ameliorated | Electroencephalogram/electromyogram (eeg/emg) | Unreported | Zhou J , et al. (2009) |
| Sensory | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Social behavior | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Physiological parameters | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Communications | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Developmental profile | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Emotion | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Immune response | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Learning & memory | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Maternal behavior | NA | Not reported | NA | NA | Zhou J , et al. (2009) |
| Molecular profile | Protein modification process | Side effect | Western blot | 3.5 -4.5 months | Zhou J , et al. (2009) |
M_PTEN_20_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mice with loxp sites flanking exons 4 and 5 in both alleles of Pten were crossed with Camk2a-Cre heterozygous mice to generate mice with Pten deleted in selectively in the forebrain; M_PTEN_1_CKO_HM; M_PTEN_10_CKO_HM; M_PTEN_12_CKO_HM; M_PTEN_9_CKO_HM
Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: Kwon et al, Nat Gen, 2001
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | () |
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 1.7 months | () |
| Motor phenotype | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | Abnormal | Immunohistochemistry | 1.8 months | () |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event frequency: inhibitory currents | Increased | Whole-cell voltage clamp | 1.7 months | () |
| Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No change | Whole-cell voltage clamp | 1.7 months | () |
| Neurophysiology | Electroencephalogram (eeg) signature | Decreased | Electroencephalogram (eeg) | 1.7 months | () |
| Neurophysiology | Action potential property: half-width | No change | Whole-cell voltage clamp | 1.7 months | () |
| Neurophysiology | Spontaneous post synaptic event frequency: inhibitory currents | No change | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | Increased | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No change | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No change | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Mitochondrial activity | No change | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Epsp-spike relationship | Increased | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Repetitive behavior | NA | Not reported | NA | NA | () |
| Repetitive behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Seizure | Electroencephalogram (eeg): signature of seizure/epilepsy | No change | Whole-cell patch clamp | 1.7 months | () |
| Seizure | Seizures | Increased | Observation of seizures | 5-7 weeks | Chen CJ , et al. (2019) |
| Seizure | Electroencephalogram (eeg): signature of seizure/epilepsy | Increased | Electroencephalogram (eeg) | 5-7 weeks | Chen CJ , et al. (2019) |
| Sensory | NA | Not reported | NA | NA | () |
| Sensory | Pain or nociception | No change | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social interaction: with juveniles | Decreased | Reciprocal social interaction test | 1.7 months | () |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social approach | No change | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Physiological parameters | NA | Not reported | NA | NA | () |
| Physiological parameters | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Communications | NA | Not reported | NA | NA | () |
| Communications | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Developmental profile | NA | Not reported | NA | NA | () |
| Developmental profile | Mortality/lethality | Increased | Kaplan-meier survival curve | 5-7 weeks | Chen CJ , et al. (2019) |
| Emotion | Anxiety | No change | Elevated plus maze test | 1.7 months | () |
| Emotion | Anxiety | Increased | Open field test | 1.7 months | () |
| Emotion | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Immune response | NA | Not reported | NA | NA | () |
| Immune response | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Learning & memory | Object recognition memory | No change | Novel object recognition test | 1.7 months | () |
| Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 5-7 weeks | Chen CJ , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Decreased | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Learning & memory | Cognitive flexibility | Decreased | T-maze test | 5-7 weeks | Chen CJ , et al. (2019) |
| Maternal behavior | NA | Not reported | NA | NA | () |
| Maternal behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Molecular profile | NA | Not reported | NA | NA | () |
| Molecular profile | Signaling: mtor pathway | Increased | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Protein phosphorylation | Increased | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Mitochondrial biogenesis | No change | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Metabolite levels: neurometabolites | Increased | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
M_PTEN_20_CKO_HM_INTERNEURON
Model Type: RESCUE-Biological
Model Genotype: Homozygous
Mutation:
P1-3 neonatal Pten conditional KO mice were injected bilaterally into the prefrontal cortex with donor cells obtained from E13.5 mice MGE expressing green fluorescent protein. Controls were injected with the acellular vehicle. Seven weeks were allowed for the transplanted MGE cells to differentiate and mature into interneurons.
Allele Type: Conditional knockout
Strain of Origin: CD1
Genetic Background: CD-1*C57Bl6/J
Es cell line: Not Specified
Model Source: Suzuki et al., 2001 (Pten^flox); Xu Tam & Anderson 2008 (Nkx2.1-Cre); Ai14 Cre-reporter (Madisen et al., 2010)
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | () |
| Motor phenotype | General locomotor activity: ambulatory activity | Refractory | Open field test | 1.7 months | () |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | Side effect | Immunohistochemistry | 1.8 months | () |
| Neurophysiology | Spontaneous post synaptic event frequency: inhibitory currents | Side effect | Whole-cell voltage clamp | 1.7 months | () |
| Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No adverse effect | Whole-cell voltage clamp | 1.7 months | () |
| Neurophysiology | Electroencephalogram (eeg) signature | Refractory | Electroencephalogram (eeg) | 1.7 months | () |
| Neurophysiology | Action potential property: half-width | Side effect | Whole-cell voltage clamp | 1.7 months | () |
| Repetitive behavior | NA | Not reported | NA | NA | () |
| Seizure | NA | Not reported | NA | NA | () |
| Sensory | NA | Not reported | NA | NA | () |
| Social behavior | Social interaction: with juveniles | Restored | Reciprocal social interaction test | 1.7 months | () |
| Physiological parameters | NA | Not reported | NA | NA | () |
| Communications | NA | Not reported | NA | NA | () |
| Developmental profile | NA | Not reported | NA | NA | () |
| Emotion | Anxiety | Refractory | Open field test | 1.7 months | () |
| Emotion | Anxiety | No adverse effect | Elevated plus maze test | 1.7 months | () |
| Immune response | NA | Not reported | NA | NA | () |
| Learning & memory | Object recognition memory | No adverse effect | Novel object recognition test | 1.7 months | () |
| Maternal behavior | NA | Not reported | NA | NA | () |
| Molecular profile | NA | Not reported | NA | NA | () |
M_PTEN_20_CKO_HM_RICTOR-ASO
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Pten CKO mice (M_PTEN_20_CKO_HM) were administered short, synthetic, single-stranded antisense oligonucleotides (ASOs) to target rictor the obligatory component of mTORC2, via a single intracerebroventricular (ICV) injection at 4 weeks.
Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: Kwon et al, Nat Gen, 2001
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Motor phenotype | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Neurophysiology | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Repetitive behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Seizure | Seizures | Ameliorated | Observation of seizures | 5-7 weeks | Chen CJ , et al. (2019) |
| Seizure | Electroencephalogram (eeg): signature of seizure/epilepsy | Ameliorated | Electroencephalogram (eeg) | 5-7 weeks | Chen CJ , et al. (2019) |
| Sensory | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Social behavior | Social memory | Restored | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Physiological parameters | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Communications | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Developmental profile | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Emotion | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Immune response | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Restored | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Learning & memory | Cognitive flexibility | Restored | T-maze test | 5-7 weeks | Chen CJ , et al. (2019) |
| Maternal behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Molecular profile | Signaling: mtor pathway | Ameliorated | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Protein phosphorylation | Restored | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
M_PTEN_20_CKO_HM_RICTOR-CKO
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Mice with loxp sites flanking exon 5 in both alleles of Pten and exon 3 of both alleles of Rictor were crossed with Camk2a-Cre heterozygous mice to generate mice with Pten and Rictor selectively deleted in the forebrain.
Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: Huang W, et al, Nat Neurosci, 2013
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Motor phenotype | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Refractory | Measurement of tissue weight | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | Restored | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No adverse effect | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Mitochondrial activity | No adverse effect | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Epsp-spike relationship | Restored | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Repetitive behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Seizure | Electroencephalogram (eeg): signature of seizure/epilepsy | Refractory | Electroencephalogram (eeg) | 5-7 weeks | Chen CJ , et al. (2019) |
| Sensory | Pain or nociception | No adverse effect | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social memory | Restored | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social interaction | Restored | Reciprocal social interaction test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social approach | No adverse effect | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Physiological parameters | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Communications | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Developmental profile | Mortality/lethality | Ameliorated | Kaplan-meier survival curve | 5-7 weeks | Chen CJ , et al. (2019) |
| Emotion | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Immune response | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Learning & memory | Object recognition memory | Restored | Novel object recognition test | 5-7 weeks | Chen CJ , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Restored | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Learning & memory | Cognitive flexibility | Restored | T-maze test | 5-7 weeks | Chen CJ , et al. (2019) |
| Maternal behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Molecular profile | Signaling: mtor pathway | Ameliorated | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Protein phosphorylation | Restored | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Mitochondrial biogenesis | No adverse effect | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Metabolite levels: neurometabolites | Restored | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
M_PTEN_20_CKO_HM_RPTOR-CKO
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
Mice with loxp sites flanking exon 5 in both alleles of Pten and exon 6 of both alleles of Rptor were crossed with Camk2a-Cre heterozygous mice to generate mice with Pten and Rptor selectively deleted in the forebrain.
Allele Type: Conditional knockout
Strain of Origin: -
Genetic Background: C57BL/6
Es cell line: -
Model Source: Jackson Laboratory (stock no. 013188).
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Motor phenotype | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Restored | Measurement of tissue weight | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event frequency: excitatory currents | Refractory | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Spontaneous post synaptic event amplitude: excitatory currents | No adverse effect | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Mitochondrial activity | No adverse effect | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
| Neurophysiology | Epsp-spike relationship | Refractory | Whole-cell patch clamp | 5-7 weeks | Chen CJ , et al. (2019) |
| Repetitive behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Seizure | Electroencephalogram (eeg): signature of seizure/epilepsy | Ameliorated | Electroencephalogram (eeg) | 5-7 weeks | Chen CJ , et al. (2019) |
| Sensory | Pain or nociception | No adverse effect | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social memory | Refractory | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social interaction | Refractory | Reciprocal social interaction test | 5-7 weeks | Chen CJ , et al. (2019) |
| Social behavior | Social approach | No adverse effect | Three-chamber social approach test | 5-7 weeks | Chen CJ , et al. (2019) |
| Physiological parameters | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Communications | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Developmental profile | Mortality/lethality | Refractory | Kaplan-meier survival curve | 5-7 weeks | Chen CJ , et al. (2019) |
| Emotion | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Immune response | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Refractory | Fear conditioning test | 5-7 weeks | Chen CJ , et al. (2019) |
| Learning & memory | Cognitive flexibility | Refractory | T-maze test | 5-7 weeks | Chen CJ , et al. (2019) |
| Maternal behavior | NA | Not reported | NA | NA | Chen CJ , et al. (2019) |
| Molecular profile | Signaling: mtor pathway | Ameliorated | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Protein phosphorylation | Refractory | Western blot | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Mitochondrial biogenesis | No adverse effect | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
| Molecular profile | Metabolite levels: neurometabolites | Refractory | Comprehensive metabolic evaluation | 5-7 weeks | Chen CJ , et al. (2019) |
M_PTEN_21_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
At P7, Pten^flx/flx animals were co-injected into the dentate gyrus with a retrovirus encoding a fluorophore (mCherry) with a downstream Cre, and a control retrovirus with just a fluorophore (GFP) and no Cre.
Allele Type: Conditional Knockout
Strain of Origin: 129S4/SvJae
Genetic Background: C57BL/6J
Es cell line: LW1
Model Source: Hong Wu Lab
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Increased | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Increased | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Increased | Sholl analysis | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Increased | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
M_PTEN_21_CKO_HM_RAPAMYCIN
Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous
Mutation:
At P7, Pten^flx/flx animals were co-injected into the dentate gyrus with a retrovirus encoding a fluorophore (mCherry) with a downstream Cre, and a control retrovirus with just a fluorophore (GFP) and no Cre. Vehicle or rapamycin (10 mg/kg of body weight) was administered intraperitoneally to Pten^flx/flx animals daily from P10 to P31.
Allele Type: Conditional Knockout
Strain of Origin: 129S4/SvJae
Genetic Background: C57BL/6J
Es cell line: LW1
Model Source: Hong Wu Lab
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Restored | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Restored | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Restored | Sholl analysis | P31 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Restored | Immunofluorescence staining | P31 | Tariq K et al. (2022) |
M_PTEN_22_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
At P7, Pten^flx/flx animals were co-injected into the dentate gyrus with a retrovirus encoding a fluorophore (GFP) with a downstream Cre, and a control retrovirus with just a fluorophore (mCherry) and no Cre.
Allele Type: Conditional Knockout
Strain of Origin: 129S4/SvJae
Genetic Background: C57BL/6J
Es cell line: LW1
Model Source: Hong Wu Lab
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Increased | Immunofluorescence staining | P28 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Increased | Immunofluorescence staining | P28 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Abnormal | Immunofluorescence staining | - | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Immunofluorescence staining | P28 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Increased | Sholl analysis | - | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Increased | Immunofluorescence staining | - | Tariq K et al. (2022) |
| Molecular profile | Signaling: PI3K/AKT pathway | Increased | Immunohistochemistry | - | Tariq K et al. (2022) |
| Molecular profile | Signaling: MTOR pathway | Increased | Immunohistochemistry | P28 | Tariq K et al. (2022) |
M_PTEN_22_CKO_HM_RPTOR_CKO
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
At P7, Pten^flx/flx;Raptor^flx/flx animals were co-injected into the dentate gyrus with a retrovirus encoding a fluorophore (GFP) with a downstream Cre, and a control retrovirus with just a fluorophore (mCherry) and no Cre. Pten^flx/flx;Raptor^flx/flx animals were generated to genetically knock out Raptor resulting in disruption of mTORC1.
Allele Type: Conditional Knockout
Strain of Origin: 129S4/SvJae; 129S/SvEv
Genetic Background: C57BL/6J
Es cell line: LW1
Model Source: Hong Wu Lab; David Sabatini
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Restored | Immunofluorescence staining | P28 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Restored | Immunofluorescence staining | P28 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Ameliorated | Immunofluorescence staining | - | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Restored | Immunofluorescence staining | P28 | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Restored | Sholl analysis | - | Tariq K et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Restored | Immunofluorescence staining | - | Tariq K et al. (2022) |
| Molecular profile | Signaling: PI3K/AKT pathway | Refractory | Immunohistochemistry | - | Tariq K et al. (2022) |
| Molecular profile | Signaling: MTOR pathway | Restored | Immunohistochemistry | P28 | Tariq K et al. (2022) |
M_PTEN_23_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional knockout mice carrying an inducible microglia-specific Pten deletion were generated by crossing Pten^flox/flox mice (MGI:2156086) with Cx3cr1^CreERT2/+ mice (MGI:5450813). The Pten-flox allele contains loxP sites flanking exon 5 of the Pten gene. The knock-in Cx3cr1-CreERT2 allele replaces exon 2 of the microglia-specific gene Cx3cr1 with a tamoxifen-inducible Cre gene (Cre recombinase fused to an estrogen receptor ligand binding domain). The knock-in Cx3cr1-CreERT2 allele also expresses EYFP. The genotype of the experimental mice is Pten^flox/flox;Cx3cr1^CreERT2/+. The genotype of control mice is Cx3cr1^CreERT2/+. Pten deletion in microglia was induced at postnatal days 0-2 (P0, P1, P2) by injection of 50 micrograms of tamoxifen in sunflower oil into the stomach.
Allele Type: Conditional knockout
Strain of Origin: 129S4/SvJae; 129P2/OlaHsd
Genetic Background: -
Es cell line: LW1; E14.1
Model Source: Jackson Laboratory
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | Decreased | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Decreased | Western blot | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Number of oligodendrocytes | No change | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neurotransporter expression | Decreased | Western blot | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neurotransporter expression | Decreased | Immunohistochemistry | P14 | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number | No change | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial number | Increased | Immunohistochemistry | P7, P14, P30, 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial morphology | Abnormal | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Astrocyte number | No change | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | Increased | Whole-cell patch clamp | P14 | Zhou X et al. (2022) |
| Neurophysiology | Miniature post synaptic currents: excitatory | Decreased | Whole-cell patch clamp | P14 | Zhou X et al. (2022) |
| Neurophysiology | Miniature post synaptic current frequency: excitatory | Decreased | Whole-cell patch clamp | P14 | Zhou X et al. (2022) |
| Neurophysiology | Miniature post synaptic current amplitude: excitatory | Decreased | Whole-cell patch clamp | P14 | Zhou X et al. (2022) |
| Repetitive behavior | Repetitive digging | No change | Marble-burying test | 2-3 months | Zhou X et al. (2022) |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | 2-3 months | Zhou X et al. (2022) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-3 months | Zhou X et al. (2022) |
| Emotion | Thigmotaxis | No change | Open field test | 2-3 months | Zhou X et al. (2022) |
| Emotion | Anxiety | No change | Open field test | 2-3 months | Zhou X et al. (2022) |
| Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 2-3 months | Zhou X et al. (2022) |
| Molecular profile | Targeted expression | Decreased | Western blot | P7, 2-3 months | Zhou X et al. (2022) |
| Molecular profile | Targeted expression | No change | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Molecular profile | Targeted expression | Decreased | Flow cytometric analysis | P7, 1 month | Zhou X et al. (2022) |
| Molecular profile | Protein expression: in situ protein expression | Increased | Immunohistochemistry | 2-3 months | Zhou X et al. (2022) |
| Molecular profile | Protein expression level evidence | Increased | Flow cytometric analysis | P14 | Zhou X et al. (2022) |
| Molecular profile | Phagocytosis | Increased | Immunohistochemistry | P14 | Zhou X et al. (2022) |
| Molecular profile | Phagocytosis | Increased | Phagocytosis assay | P7 | Zhou X et al. (2022) |
| Molecular profile | Gene expression: activated microglia | Increased | Flow cytometric analysis | 2-3 months | Zhou X et al. (2022) |
| Molecular profile | Differential gene expression | Abnormal | RNA sequencing | P7, P14, 2-3 months | Zhou X et al. (2022) |
| Molecular profile | Cell differentiation | No change | RNA sequencing | P7, P14, 2-3 months | Zhou X et al. (2022) |
M_PTEN_2_CKO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Conditional heterozygous deletion of exon 5 of the Pten gene , that encodes the phosphatase domain, using Nse-cre (or Enolas2-cre) in neurons of the cortex, hippocampus and cerebellum
Allele Type: Conditional loss-of-function
Strain of Origin: BALB/c
Genetic Background: C57BL/6
Es cell line: 129S4/SvJae
Model Source: Not specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Motor phenotype | Swimming ability | No change | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Elevated plus maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | General locomotor activity | No change | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | No change | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: ampa receptors | No change | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | No change | Measurement of tissue weight | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No change | Measurement of tissue weight | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | 5-7 months | Napoli E , et al. (2012) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Measurement of tissue weight | 5-7 months | Napoli E , et al. (2012) |
| Neurophysiology | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Repetitive behavior | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Repetitive behavior | Self grooming: perseveration | No change | Grooming behavior assessments | 8-13 weeks | Napoli E , et al. (2012) |
| Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 5-7 months | Napoli E , et al. (2012) |
| Seizure | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Sensory | Startle response | No change | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Social behavior | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Social behavior | Social interaction | No change | Three-chamber social approach test | 8-13 weeks | Napoli E , et al. (2012) |
| Social behavior | Social interaction | No change | Three-chamber social approach test | 8-13 weeks | Napoli E , et al. (2012) |
| Social behavior | Social interaction | Decreased | Three-chamber social approach test | 5-7 months | Napoli E , et al. (2012) |
| Social behavior | Social interaction | Decreased | Three-chamber social approach test | 5-7 months | Napoli E , et al. (2012) |
| Physiological parameters | Satiety response | No change | Food intake measurements | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Physiological parameters | Oxidative stress: systemic | Increased | Mitochondrial respiratory chain enzyme analysis | 5-6 months | Napoli E , et al. (2012) |
| Physiological parameters | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Communications | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Developmental profile | Size/growth | No change | Body weight measurement | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Emotion | Anxiety | No change | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Emotion | Anxiety | No change | Elevated plus maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Immune response | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Learning & memory | Spatial working memory | No change | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Spatial reference memory | No change | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Object recognition memory | No change | Novel object recognition test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: passive avoidance | Decreased | Passive avoidance test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Cognitive flexibility: associative learning | No change | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Maternal behavior | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Napoli E , et al. (2012) |
| Molecular profile | Targeted expression | Decreased | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Signaling | No change | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Signaling | Increased | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Protein localization: synapse | No change | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Signaling | Decreased | Western blot | 5-7 months | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | No change | Western blot | 4-29 weeks | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | No change | Western blot | 4-6 weeks | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | No change | Western blot | 4-29 weeks | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | No change | Western blot | 8-13 weeks | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | Increased | Western blot | 5-7 months | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | Decreased | Western blot | 5-7 months | Napoli E , et al. (2012) |
| Molecular profile | Protein expression level evidence | Decreased | Western blot | 4-29 weeks | Napoli E , et al. (2012) |
| Molecular profile | Mitochondrial dna replication | Increased | Quantitative pcr (qrt-pcr) | 8-13 weeks | Napoli E , et al. (2012) |
| Molecular profile | Mitochondrial biogenesis | No change | Mitochondrial respiratory chain enzyme analysis | 8-13 weeks | Napoli E , et al. (2012) |
| Molecular profile | Mitochondrial biogenesis | No change | Mitochondrial respiratory chain enzyme analysis | 4-6 weeks | Napoli E , et al. (2012) |
| Molecular profile | Enzyme activity | No change | Mitochondrial respiratory chain enzyme analysis | 4-29 weeks | Napoli E , et al. (2012) |
| Molecular profile | Enzyme activity | Decreased | Mitochondrial respiratory chain enzyme analysis | 5-7 months | Napoli E , et al. (2012) |
M_PTEN_2_CKO_HT_FASTING
Model Type: RESCUE-Dietary
Model Genotype: Heterozygous
Mutation:
Male Pten heterozygous CKO, with loss of Pten from neural tissue, were subjected to long-term intermittent-fasting, consisting of daily alternations of ad limitum food followed by a day of complete fasting, starting when animals were 3-4 months old and continued for 60 days.
Allele Type: Multifactorial
Strain of Origin: -
Genetic Background: C57BL/6J
Es cell line: -
Model Source: Not specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | Swimming ability | No adverse effect | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No adverse effect | Elevated plus maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Motor phenotype | General locomotor activity | No adverse effect | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: nmda receptors | No adverse effect | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: glutamate receptors: ampa receptors | No adverse effect | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Hippocampal morphology | No adverse effect | Measurement of tissue weight | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cerebellar morphology | No adverse effect | Measurement of tissue weight | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Refractory | Measurement of tissue weight | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Sensory | Startle response | Side effect | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Social behavior | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Physiological parameters | Satiety response | Side effect | Food intake measurements | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Developmental profile | Size/growth | Side effect | Body weight measurement | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Emotion | Anxiety | Side effect | Open field test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Emotion | Anxiety | Side effect | Elevated plus maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Spatial working memory | No adverse effect | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Spatial reference memory | No adverse effect | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Object recognition memory | No adverse effect | Novel object recognition test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: passive avoidance | Restored | Passive avoidance test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Learning & memory | Cognitive flexibility: associative learning | No adverse effect | Morris water maze test | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Targeted expression | Refractory | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Signaling | Restored | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Signaling | No adverse effect | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
| Molecular profile | Protein localization: synapse | No adverse effect | Western blot | 5-6 months | Cabral-Costa JV , et al. (2018) |
M_PTEN_3_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exons 4-5 of the Pten gene using Nse-cre, authors in PMID 23487788 (Takeuchi K et al 2013) specifically show loss of Pten in granule cells of dentate gyrus and pyramidal neurons of hippocampal CA3 and a subset of postmitotic neruons in the cortex. Same CKOs produced in PMID:16675393
Allele Type: Conditional (knockout)
Strain of Origin: Not specified
Genetic Background: C57BL/6
Es cell line: Not specified
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Abnormal | Histology | 5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic transmission | No change | Whole-cell patch clamp | 8-30 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic transmission | No change | Whole-cell patch clamp | 8-20 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic transmission | Increased | Whole-cell patch clamp | 3.5-5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | No change | Whole-cell patch clamp | 8-12 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | No change | Whole-cell patch clamp | 8-20 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Increased | Whole-cell patch clamp | 8-12 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Decreased | Whole-cell patch clamp | 4-5months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Decreased | Whole-cell patch clamp | 2-7.5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Synaptic plasticity | Decreased | Whole-cell patch clamp | 3.5-7.5 months | Takeuchi K , et al. (2013) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell patch clamp | 8-30 weeks | Takeuchi K , et al. (2013) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | Decreased | Whole-cell patch clamp | 3.5-5 months | Takeuchi K , et al. (2013) |
| Molecular profile | Protein expression level evidence | Decreased | Immunohistochemistry | 8 weeks | Takeuchi K , et al. (2013) |
M_PTEN_4_KI_M3M4_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
M3M4 missense double mutations were targeted into the Pten exon 7, which contains the NLS-like sequence.
Allele Type: Targeted (knockin)
Strain of Origin: CD1
Genetic Background: CD1
Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Motor phenotype | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Increased | Immunohistochemistry | 6 weeks | Frazier TW , et al. (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology and size of the corpus callosum | Increased | Immunohistochemistry | 6 weeks | Frazier TW , et al. (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | No change | Immunohistochemistry | 6 weeks | Frazier TW , et al. (2014) |
| Neurophysiology | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Repetitive behavior | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Seizure | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Sensory | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Social behavior | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Physiological parameters | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Communications | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Developmental profile | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Emotion | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Immune response | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Learning & memory | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Maternal behavior | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Molecular profile | Gene expression | Abnormal | Rna sequencing | 6 weeks | Frazier TW , et al. (2014) |
M_PTEN_5_KI_M3M4_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
M3M4 missense double mutations were targeted into the Pten exon 7, which contains the NLS-like sequence.
Allele Type: Targeted (knockin)
Strain of Origin: CD1
Genetic Background: CD1
Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Motor phenotype | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Myelination | Increased | Immunohistochemistry | 6 weeks | Frazier TW , et al. (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology and size of the corpus callosum | Increased | Immunohistochemistry | 6 weeks | Frazier TW , et al. (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | No change | Immunohistochemistry | 6 weeks | Frazier TW , et al. (2014) |
| Neurophysiology | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Repetitive behavior | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Seizure | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Sensory | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Social behavior | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Physiological parameters | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Communications | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Developmental profile | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Emotion | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Immune response | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Learning & memory | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Maternal behavior | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
| Molecular profile | NA | Not reported | NA | NA | Frazier TW , et al. (2014) |
M_PTEN_6_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Deletion of gene sequence from BglII site in exon 5 to the next BglII site 2.0 kb downstream.
Allele Type: Targeted (knockout)
Strain of Origin: 129Sv/J
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Circadian sleep/wake cycle | Locomotor activity in diurnal cycle | Increased | Running wheel test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Circadian sleep/wake cycle | Locomotor activity in diurnal cycle | Decreased | Running wheel test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Circadian sleep/wake cycle | Circadian rhythms: timing/phases of locomotor activity | No change | Running wheel test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Circadian sleep/wake cycle | Adaptation to dark phase | No change | Running wheel test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Circadian sleep/wake cycle | Adaptation to dark phase | Decreased | Running wheel test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Motor phenotype | Motor learning | no change | Accelerating rotarod test | P 78-128 | Clipperton-Allen AE et al. (2022) |
| Motor phenotype | Motor coordination and balance: fine motor skills | no change | Single-seed reaching test | P 68-116 | Clipperton-Allen AE et al. (2022) |
| Motor phenotype | Motor coordination and balance | no change | Accelerating rotarod test | P 78-128 | Clipperton-Allen AE et al. (2022) |
| Motor phenotype | Motor coordination and balance | increased | Accelerating rotarod test | P 78-128 | Clipperton-Allen AE et al. (2022) |
| Motor phenotype | General locomotor activity | no change | Three-chamber social approach test | juvenile, P 35, P 45, adult | Clipperton-Allen AE et al. (2022) |
| Motor phenotype | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Three-chamber social approach test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cued or contextual fear conditioning: trace fear conditioning | no change | Fear conditioning test | P 88-132 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cued or contextual fear conditioning: memory of cue: long term recall | no change | Fear conditioning test | P 73-123 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cued or contextual fear conditioning: memory of cue: long term recall | no change | Fear conditioning test | P 91-141 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cued or contextual fear conditioning: memory of context: long term recall | decreased | Fear conditioning test | P 73-123 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cued or contextual fear conditioning: memory of context: long term recall | no change | Fear conditioning test | P 91-141 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | increased | Magnetic resonance imaging (MRI) | P 7,P 60 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | abnormal | Magnetic resonance imaging (MRI) | P 7,P 60 | Clipperton-Allen AE et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial number | No change | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial number | Increased | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial morphology | Increased | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Microglial morphology | Increased | Immunohistochemistry | 2 weeks | Xu ZX et al. (2020) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | General observations | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain morphology | Abnormal | Measurement of tissue weight | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Neurophysiology | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Neurophysiology | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Repetitive behavior | Self grooming: perseveration | Increased | Resident-intruder test | 11-16 weeks | Clipperton-Allen AE and Page DT (2015) |
| Repetitive behavior | Repetitive digging | Increased | Resident-intruder test | 11-16 weeks | Clipperton-Allen AE and Page DT (2015) |
| Repetitive behavior | Repetitive digging | Increased | Marble-burying test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Repetitive behavior | Repetitive digging | No change | Marble-burying test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Seizure | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Seizure | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Sensory | Startle response: acoustic stimulus | no change | Acoustic startle reflex test | juvenile, adolescent, adult | Clipperton-Allen AE et al. (2022) |
| Sensory | Startle response: acoustic stimulus | increased | Acoustic startle reflex test | juvenile, adult | Clipperton-Allen AE et al. (2022) |
| Sensory | Startle response: acoustic stimulus | decreased | Acoustic startle reflex test | juvenile, adult | Clipperton-Allen AE et al. (2022) |
| Sensory | Sensorimotor gating | decreased | Prepulse inhibition | P 57-128 | Clipperton-Allen AE et al. (2022) |
| Sensory | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Sensory | Pain or nociception | No change | Hot plate test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social approach | no change | Three-chamber social approach test | juvenile, adult | Clipperton-Allen AE et al. (2022) |
| Social behavior | Social approach | decreased | Three-chamber social approach test | P 45, adult | Clipperton-Allen AE et al. (2022) |
| Social behavior | Social interaction | Decreased | Resident-intruder test | 11-16 weeks | Clipperton-Allen AE and Page DT (2015) |
| Social behavior | Rearing behavior | Increased | Resident-intruder test | 11-16 weeks | Clipperton-Allen AE and Page DT (2015) |
| Social behavior | Aggression | Decreased | Resident-intruder test | 11-16 weeks | Clipperton-Allen AE and Page DT (2015) |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social interaction | No change | Reciprocal social interaction test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social habituation | Decreased | Reciprocal social interaction test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social habituation | No change | Reciprocal social interaction test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social dishabituation | No change | Reciprocal social interaction test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Physiological parameters | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Communications | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Communications | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Developmental profile | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Developmental profile | Size/growth | No change | General observations | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Response to novelty | decreased | Novel object recognition test | P 84-116 | Clipperton-Allen AE et al. (2022) |
| Emotion | Response to novelty | no change | Novel object recognition test | P 52-99 | Clipperton-Allen AE et al. (2022) |
| Emotion | Habituation to aversive stimuli | no change | Acoustic startle reflex test | P 61-116 | Clipperton-Allen AE et al. (2022) |
| Emotion | Habituation to aversive stimuli | no change | Acoustic startle reflex test | P 57-128 | Clipperton-Allen AE et al. (2022) |
| Emotion | Exploratory activity | decreased | Novel object recognition test | P 52-116 | Clipperton-Allen AE et al. (2022) |
| Emotion | Anxiety | no change | Open field test | P 71-170 | Clipperton-Allen AE et al. (2022) |
| Emotion | Exploratory activity | Increased | Resident-intruder test | 11-16 weeks | Clipperton-Allen AE and Page DT (2015) |
| Emotion | Depression | Increased | Tail suspension test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Depression | Increased | Forced swim test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Depression | No change | Tail suspension test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Depression | No change | Forced swim test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Anxiety | Decreased | Open field test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Anxiety | Decreased | Light-dark exploration test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Anxiety | No change | Open field test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Emotion | Anxiety | No change | Light-dark exploration test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Immune response | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Immune response | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Learning & memory | Spatial working memory | no change | Morris water maze test | P 52-89 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Spatial working memory | decreased | Morris water maze test | P 60-89 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Spatial learning | no change | Morris water maze test | P 52-89 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Procedural learning | no change | Puzzle box test | P 57-99 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Procedural learning | increased | Puzzle box test | P 64-162 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Extinction of fear memory | no change | Fear conditioning test | P 62-118 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Cognitive flexibility | no change | Puzzle box test | P 57-99 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Cognitive flexibility | no change | Morris water maze test | P 52-89 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | Cognitive flexibility | increased | Puzzle box test | P 64-162 | Clipperton-Allen AE et al. (2022) |
| Learning & memory | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Learning & memory | Cued or contextual fear conditioning: trace fear conditioning | No change | Fear conditioning test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Learning & memory | Cued or contextual fear conditioning: trace fear conditioning | Decreased | Fear conditioning test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Decreased | Fear conditioning test | 7-20 weeks | Clipperton-Allen AE and Page DT (2014) |
| Maternal behavior | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Molecular profile | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2015) |
| Molecular profile | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
M_PTEN_7_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 5 of the Pten gene using endogenous Slc6a3 (Dopamine transporter, DAT)-cre, in dopaminergic neurons
Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Motor phenotype | General locomotor activity: ambulatory activity | Abnormal | Three-chamber social approach test | 7-15 weeks | Clipperton-Allen AE and Page DT (2014) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Three-chamber social approach test | 7-15 weeks | Clipperton-Allen AE and Page DT (2014) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Neurophysiology | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Repetitive behavior | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Seizure | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Sensory | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | 7-15 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social memory | No change | Three-chamber social approach test | 7-15 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social approach | No change | Three-chamber social approach test | 7-15 weeks | Clipperton-Allen AE and Page DT (2014) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 7-15 weeks | Clipperton-Allen AE and Page DT (2014) |
| Physiological parameters | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Communications | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Developmental profile | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Emotion | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Immune response | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Learning & memory | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Maternal behavior | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
| Molecular profile | NA | Not reported | NA | NA | Clipperton-Allen AE and Page DT (2014) |
M_PTEN_8_CKO_HM_DG
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exon 5 of the Pten gene using a T2A-cre containing retrovirus injected bilaterally into dentate gyrus at postnatal day 7
Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
Es cell line: Not Specified
Model Source: Not Specified
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: excitatory | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Increased | Immunohistochemistry | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Fluorescence microscopy | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Fluorescence microscopy | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Increased | Fluorescence microscopy | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Synaptic transmission: inhibitory | No change | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Synaptic transmission: excitatory | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | No change | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Neurotransmitter release: quantal parameters | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Neuronal activation | Increased | Immunohistochemistry | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Network excitability | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Miniature post synaptic current frequency: excitatory | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Miniature post synaptic current amplitude: excitatory | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Ion influx and permeability: calcium | Increased | Fluorescence microscopy | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Intrinsic membrane properties | Abnormal | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Neurophysiology | Action potential property: firing rate | Increased | Whole-cell patch clamp | 3-4.5 weeks | Williams MR , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Developmental profile | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Williams MR , et al. (2015) |
| Molecular profile | Targeted expression | Decreased | Immunohistochemistry | 2 weeks | Williams MR , et al. (2015) |
M_PTEN_9_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of exons 4-5 of the PTEN gene using Nkx2.1-Cre, in the ventricular zone of the medical ganglionic eminence (MGE) that gives rise to interneurons starting E9.5. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | General locomotor activity | No change | Open field test | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal size | Increased | Immunohistochemistry | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: interneurons | Decreased | Immunohistochemistry | P0, p8, 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Decreased | NA | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | Decreased | NA | E15.5, 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Histology | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Increased | Immunohistochemistry | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | Spontaneous post synaptic events: inhibitory currents | Increased | Whole-cell patch clamp | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | Spontaneous post synaptic event amplitude: inhibitory currents | No change | Whole-cell patch clamp | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | Electroencephalogram (eeg) signature | Increased | Electroencephalogram (eeg) | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | Apoptosis: brain cells | Increased | Expression of cleaved caspase-3 (cc3) | E17.5, p0 | Vogt D , et al. (2015) |
| Neurophysiology | Apoptosis: brain cells | Increased | Expression of cleaved caspase-3 (cc3) | P0 | Vogt D , et al. (2015) |
| Neurophysiology | Apoptosis: brain cells | Increased | Cell counting | P0 | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | Social interaction | Decreased | Reciprocal social interaction test | P30 | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | Size/growth | Decreased | Body weight measurement | 4 weeks | Vogt D , et al. (2015) |
| Developmental profile | Mortality/lethality | No change | General observations | NA | Vogt D , et al. (2015) |
| Emotion | Anxiety | No change | Open field test | NA | Vogt D , et al. (2015) |
| Emotion | Anxiety | No change | Elevated plus maze test | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | Object recognition memory | Decreased | Novel object recognition test | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | Protein phosphorylation | Increased | Western blot | E13.5 | Vogt D , et al. (2015) |
| Molecular profile | Cell proliferation | No change | Phospho-histone 3 expression | NA | Vogt D , et al. (2015) |
| Molecular profile | Cell proliferation | No change | Edu incorporation | NA | Vogt D , et al. (2015) |
M_PTEN_9_CKO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Conditional heterozygous deletion of exons 4-5 of the PTEN gene using Nkx2.1-Cre in the ventricular zone of the medical ganglionic eminence (MGE) that gives rise to interneurons starting E9.5. The tdtomato reporter under Ai14 Flox/+ line was used to follow expression of the cre recombinase.
Allele Type: Conditional loss-of-function
Strain of Origin: CD1* C56BL/6
Genetic Background: CD1
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Motor phenotype | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal differentiation | No change | NA | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Histology | 4 weeks | Vogt D , et al. (2015) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | No change | Immunohistochemistry | 4 weeks | Vogt D , et al. (2015) |
| Neurophysiology | Spontaneous post synaptic events: inhibitory currents | No change | Whole-cell patch clamp | 4 weeks | Vogt D , et al. (2015) |
| Repetitive behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Seizure | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Sensory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Social behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Physiological parameters | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Communications | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Developmental profile | Size/growth | No change | Body weight measurement | 4 weeks | Vogt D , et al. (2015) |
| Developmental profile | Mortality/lethality | No change | General observations | NA | Vogt D , et al. (2015) |
| Emotion | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Immune response | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Learning & memory | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Maternal behavior | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
| Molecular profile | NA | Not reported | NA | NA | Vogt D , et al. (2015) |
Other PTEN Rescue Models(8 Models)
| M_PTEN_1_CKO_HM | 2 | Genetic | Pharmaceutical | Rapamycin |
| M_PTEN_2_CKO_HT | 1 | Genetic | Dietary | Fasting |
| M_PTEN_20_CKO_HM | 1 | Genetic | Biological | Interneuron |
| M_PTEN_20_CKO_HM | 1 | Genetic | Genetic | Rictor antisense oligonucleotide |
| M_PTEN_20_CKO_HM | 1 | Genetic | Genetic | Rictor conditional knockout |
| M_PTEN_20_CKO_HM | 1 | Genetic | Genetic | Rptor conditional knockout |
| M_PTEN_21_CKO_HM | 1 | Genetic | Pharmaceutical | Rapamycin |
| M_PTEN_22_CKO_HM | 1 | Genetic | Genetic | Rptor conditional knockout |
CNVs associated with PTEN(1 Models)
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| 10q23.31 | 8 | Deletion | 15 / 44 |