Genetic Animal Models / SHANK2

SHANK2 SH3 and multiple ankyrin repeat domains 2

Model Species
Rattus norvegicus
Gene Aliases
CortBP1, ProSAP1, Spank-3
Reports
1
Associated Human Genes
SHANK2
Models / Rescue Models
5 / 2
Rescue Model
-
Model Summary

Shank2 knockout rats exhibit decreased social behaviors and increased repetitive behaviors.

Reports related to SHANK2 (1 Reports)
# Type Title Author, Year
1 Primary Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism. Modi ME , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

R_SHANK2_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

ZFN targeted to exon 31 of Shank2, targeting PDZ domain

Allele Type: Knockout
Strain of Origin: Sprague Dawley
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Modi ME , et al. (2018)
Communications - Not Reported - - Modi ME , et al. (2018)
Developmental profile - Not Reported - - Modi ME , et al. (2018)
Emotion Exploratory activity Decreased Object preference test 2-3 months Modi ME , et al. (2018)
Homeostasis - Not Reported - - Modi ME , et al. (2018)
Immune response - Not Reported - - Modi ME , et al. (2018)
Learning & memory Reward reinforced choice behavior Increased Operant self-learning paradigm 2-3 months Modi ME , et al. (2018)
Learning & memory Cognitive flexibility: Associative learning: operant self-learning Decreased Operant self-learning paradigm 2-3 months Modi ME , et al. (2018)
Maternal behavior - Not Reported - - Modi ME , et al. (2018)
Molecular profile Targeted protein expression Decreased Quantitative PCR (qRT-PCR); Western blot Unreported Modi ME , et al. (2018)
Molecular profile Protein localization: synapse No Change Fractionation Unreported Modi ME , et al. (2018)
Molecular profile Protein localization: synapse No Change Fractionation Unreported Modi ME , et al. (2018)
Molecular profile Protein localization: synapse Increased Fractionation Unreported Modi ME , et al. (2018)
Motor phenotype Hyperactivity No Change Operant self-learning paradigm 2-3 months Modi ME , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity Increased Open field test 2-3 months Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size Increased Golgi-Cox staining Unreported Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal size Decreased Golgi-Cox staining Unreported Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Increased Golgi-Cox staining; Sholl analysis Unreported Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Golgi-Cox staining; Sholl analysis Unreported Modi ME , et al. (2018)
Neurophysiology Synaptic plasticity: striatal LTD Increased Field potential recordings Unreported Modi ME , et al. (2018)
Neurophysiology Synaptic plasticity: hippocampal LTP Decreased Field potential recordings Unreported Modi ME , et al. (2018)
Neurophysiology Synaptic plasticity: hippocampal LTD Decreased Field potential recordings Unreported Modi ME , et al. (2018)
Neurophysiology Synaptic neuroreceptor ratio (NMDAR/AMPAR) dependent transmission Increased Field potential recordings Unreported Modi ME , et al. (2018)
Neurophysiology Event related oscillations (EROs) in electroencephalography (EEG) Abnormal Power spectral analysis Unreported Modi ME , et al. (2018)
Repetitive behavior Circling Increased Open field test 2-3 months Modi ME , et al. (2018)
Seizure - Not Reported - - Modi ME , et al. (2018)
Sensory - Not Reported - - Modi ME , et al. (2018)
Social behavior Social memory No Change Three-chamber social approach test 2-3 months Modi ME , et al. (2018)
Social behavior Social interaction: with juveniles Decreased Reciprocal social interaction test 2-3 months Modi ME , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 2-3 months Modi ME , et al. (2018)
Social behavior Social habituation Decreased Reciprocal social interaction test 2-3 months Modi ME , et al. (2018)
Social behavior Social approach No Change Three-chamber social approach test 2-3 months Modi ME , et al. (2018)
Social behavior Rearing behavior Increased Open field test 2-3 months Modi ME , et al. (2018)
Social behavior Juvenile play Decreased Reciprocal social interaction test 5-6 weeks Modi ME , et al. (2018)

R_SHANK2_1_KO_HM_JNJ16259685

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

ZFN targeted to exon 31 of Shank2, targeting PDZ domain, administration of mGluR1 antagonist JNJ16259685 0.63 mg/kg, s.c.

Allele Type: Knockout
Strain of Origin: Sprague Dawley
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Modi ME , et al. (2018)
Communications - Not Reported - - Modi ME , et al. (2018)
Developmental profile - Not Reported - - Modi ME , et al. (2018)
Emotion Exploratory activity Restored Object preference test 2-3 months Modi ME , et al. (2018)
Homeostasis - Not Reported - - Modi ME , et al. (2018)
Immune response - Not Reported - - Modi ME , et al. (2018)
Learning & memory - Not Reported - - Modi ME , et al. (2018)
Maternal behavior - Not Reported - - Modi ME , et al. (2018)
Molecular profile - Not Reported - - Modi ME , et al. (2018)
Motor phenotype - Not Reported - - Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Modi ME , et al. (2018)
Neurophysiology Synaptic plasticity: striatal LTD Restored Field potential recordings Unreported Modi ME , et al. (2018)
Repetitive behavior Circling Ameliorated Open field test 2-3 months Modi ME , et al. (2018)
Seizure - Not Reported - - Modi ME , et al. (2018)
Sensory - Not Reported - - Modi ME , et al. (2018)
Social behavior Social interaction Ameliorated Reciprocal social interaction test 2-3 months Modi ME , et al. (2018)
Social behavior Rearing behavior Restored Open field test 2-3 months Modi ME , et al. (2018)

R_SHANK2_1_KO_HM_SCH-39166-1

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

ZFN targeted to exon 31 of Shank2, targeting PDZ domain, animals were treated with the dopamine D1 receptor antagonist SCH-39166 0.01 mg/kg i.p.

Allele Type: Knockout
Strain of Origin: Sprague Dawley
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Modi ME , et al. (2018)
Communications - Not Reported - - Modi ME , et al. (2018)
Developmental profile - Not Reported - - Modi ME , et al. (2018)
Emotion - Not Reported - - Modi ME , et al. (2018)
Homeostasis - Not Reported - - Modi ME , et al. (2018)
Immune response - Not Reported - - Modi ME , et al. (2018)
Learning & memory Reward reinforced choice behavior Refractory Operant self-learning paradigm 2-3 months Modi ME , et al. (2018)
Maternal behavior - Not Reported - - Modi ME , et al. (2018)
Molecular profile - Not Reported - - Modi ME , et al. (2018)
Motor phenotype - Not Reported - - Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Modi ME , et al. (2018)
Neurophysiology - Not Reported - - Modi ME , et al. (2018)
Repetitive behavior Circling Ameliorated Open field test 2-3 months Modi ME , et al. (2018)
Seizure - Not Reported - - Modi ME , et al. (2018)
Sensory - Not Reported - - Modi ME , et al. (2018)
Social behavior - Not Reported - - Modi ME , et al. (2018)

R_SHANK2_1_KO_HM_SCH-39166-2

Model Type: RESCUE-Pharmaceutical
Model Genotype: Homozygous

Mutation:

ZFN targeted to exon 31 of Shank2, targeting PDZ domain, animals were treated with the dopamine D1 receptor antagonist SCH-39166 0.1 mg/kg i.p.

Allele Type: Knockout
Strain of Origin: Sprague Dawley
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Modi ME , et al. (2018)
Communications - Not Reported - - Modi ME , et al. (2018)
Developmental profile - Not Reported - - Modi ME , et al. (2018)
Emotion - Not Reported - - Modi ME , et al. (2018)
Homeostasis - Not Reported - - Modi ME , et al. (2018)
Immune response - Not Reported - - Modi ME , et al. (2018)
Learning & memory Reward reinforced choice behavior Ameliorated Operant self-learning paradigm 2-3 months Modi ME , et al. (2018)
Maternal behavior - Not Reported - - Modi ME , et al. (2018)
Molecular profile - Not Reported - - Modi ME , et al. (2018)
Motor phenotype - Not Reported - - Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Modi ME , et al. (2018)
Neurophysiology - Not Reported - - Modi ME , et al. (2018)
Repetitive behavior Circling Ameliorated Open field test 2-3 months Modi ME , et al. (2018)
Seizure - Not Reported - - Modi ME , et al. (2018)
Sensory - Not Reported - - Modi ME , et al. (2018)
Social behavior - Not Reported - - Modi ME , et al. (2018)

R_SHANK2_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

ZFN targeted to exon 31 of Shank2, targeting PDZ domain

Allele Type: Knockout
Strain of Origin: Sprague Dawley
Genetic Background: Sprague Dawley

Es cell line: -
Model Source: SAGE Labs
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Modi ME , et al. (2018)
Communications - Not Reported - - Modi ME , et al. (2018)
Developmental profile - Not Reported - - Modi ME , et al. (2018)
Emotion - Not Reported - - Modi ME , et al. (2018)
Homeostasis - Not Reported - - Modi ME , et al. (2018)
Immune response - Not Reported - - Modi ME , et al. (2018)
Learning & memory - Not Reported - - Modi ME , et al. (2018)
Maternal behavior - Not Reported - - Modi ME , et al. (2018)
Molecular profile Targeted protein expression Decreased Quantitative PCR (qRT-PCR); Western blot Unreported Modi ME , et al. (2018)
Motor phenotype - Not Reported - - Modi ME , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Modi ME , et al. (2018)
Neurophysiology - Not Reported - - Modi ME , et al. (2018)
Repetitive behavior - Not Reported - - Modi ME , et al. (2018)
Seizure - Not Reported - - Modi ME , et al. (2018)
Sensory - Not Reported - - Modi ME , et al. (2018)
Social behavior - Not Reported - - Modi ME , et al. (2018)
Other SHANK2 Rescue Models(2 Models)
R_SHANK2_1_KO_HM 1 Genetic Pharmaceutical JNJ 16259685
R_SHANK2_1_KO_HM 2 Genetic Pharmaceutical SCH-39166
CNVs associated with SHANK2(1 Models)
11q13.3-q13.4 4 Duplication 7  /  4
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