Genetic Mouse Models / SYBU

SYBU syntabulin

Model Species
Mus musculus
Gene Aliases
Golsyn
Reports
1
Associated Human Genes
SYBU
Models / Rescue Models
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Rescue Model
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Model Summary

Mice with conditional deletion of Sybu in neurons show no change in viability or fertility, decreased body weight, decreased ability to compete for food and water during early development, decreased axonal transport, decreased synaptogenesis, decreased spine density in hippocampal pyramidal neurons especially mushroom spines, abnormal structures of synaptic active zones, decreased synaptic function, impaired synaptic plasticity. 8-10 weeks old sybu cKO mice show no change in sociability but decreased social recognition, no change in non social odor recognition, decreased communication, increased self-grooming, and impaired spatial learning and memory. Sybu cKO mice show no changes in aggression, motor coordination and balance, locomotor activity, anxiety andsensory perception. Expressing human ASD linked Sybu variant Sybu-R178Q fails to rescue reduced synapse formation and impaired synaptic transmission and plasticity in sybu cKO neurons.

Reports related to SYBU (1 Reports)
# Type Title Author, Year
1 Primary Defects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits Xiong GJ et al. (2020)
Show all Construct Details Show all Phenotypic Profiles

M_SYBU_1_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Nestin-Cre; stbLoxP/LoxP cKO mouse, in which central and peripheral nervous system-selective inactivation of the sybu gene was achieved by deleting exons 4 and 5, leading to a frameshifting that generates a premature stop codon in exon 6 after crossing stb^LoxP/LoxP and Nestin-Cre mice.

Allele Type: Conditional knockout
Strain of Origin: C57BL/6J
Genetic Background: C57BL/6J

Es cell line: NA
Model Source: NA
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Physiological parameters Reproductive function No change Genotypic ratio of progeny from heterozygous parents Adult Xiong GJ et al. (2020)
Motor phenotype Swimming ability No change Morris water maze test 2-2.5 months Xiong GJ et al. (2020)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 2-2.5 months Xiong GJ et al. (2020)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology: synaptic cleft length No change Electron microscopy 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology: active zone Abnormal Electron microscopy 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Somatosensory cortical map architecture No change Immunohistochemistry 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size: inhibitory synapses No change Western blot 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size: excitatory synapses No change Western blot 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size No change Electron microscopy 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: nmda receptors No change Western blot 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: glutamate receptors: ampa receptors Decreased Western blot 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology No change Immunohistochemistry 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Abnormal Electron microscopy 2.5 months Xiong GJ et al. (2020)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Electron microscopy 2.5 months Xiong GJ et al. (2020)
Neurophysiology Synaptic plasticity: hippocampal ltp Decreased Field potential recordings 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Synaptic plasticity: hippocampal ltd Decreased Field potential recordings 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission No change Whole-cell patch clamp 3-4 weeks Xiong GJ et al. (2020)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Membrane potential No change Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Intrinsic membrane properties No change Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Epsp-spike relationship Decreased Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Neurophysiology Action potential property: firing rate No change Whole-cell patch clamp 2-2.5 months Xiong GJ et al. (2020)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 2-2.5 months Xiong GJ et al. (2020)
Sensory Sensorimotor gating No change Prepulse inhibition 2-2.5 months Xiong GJ et al. (2020)
Sensory Olfaction No change Buried food test 2-2.5 months Xiong GJ et al. (2020)
Social behavior Social memory Decreased Three-chamber social approach test 2-2.5 months Xiong GJ et al. (2020)
Social behavior Social habituation No change Habituation-dishabituation test 2-2.5 months Xiong GJ et al. (2020)
Social behavior Social dishabituation Decreased Habituation-dishabituation test 2-2.5 months Xiong GJ et al. (2020)
Social behavior Social approach No change Three-chamber social approach test 2-2.5 months Xiong GJ et al. (2020)
Social behavior Aggression No change Cotton bud biting test 2-2.5 months Xiong GJ et al. (2020)
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations P3-12 Xiong GJ et al. (2020)
Communications Ultrasonic vocalization: interaction induced: opposite sex stimulus Decreased Monitoring ultrasonic vocalizations 2-2.5 months Xiong GJ et al. (2020)
Developmental profile Size/growth Decreased Body weight measurement 3 weeks-adult Xiong GJ et al. (2020)
Developmental profile Mortality/lethality No change General observations Adult Xiong GJ et al. (2020)
Emotion Anxiety No change Elevated plus maze test 2-2.5 months Xiong GJ et al. (2020)
Emotion Anxiety No change Open field test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Spatial working memory No change Morris water maze test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Spatial reference memory Decreased Morris water maze test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Olfactory learning and memory No change Olfactory habituation-dishabituation test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Object recognition memory No change Novel object recognition test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Cued or contextual fear conditioning: memory of context Decreased Fear conditioning test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Cued or contextual fear conditioning: extinction Decreased Fear conditioning test 2-2.5 months Xiong GJ et al. (2020)
Learning & memory Cognitive flexibility Decreased Morris water maze test 2-2.5 months Xiong GJ et al. (2020)
Molecular profile Targeted expression Decreased Western blot 2.5 months Xiong GJ et al. (2020)
Molecular profile Protein expression: in situ protein expression Decreased Western blot 2.5 months Xiong GJ et al. (2020)
Molecular profile Protein expression level evidence No change Western blot 2.5 months Xiong GJ et al. (2020)
CNVs associated with SYBU(1 Models)
8q23.2 4 Deletion 10  /  11
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