Motor phenotype |
Swimming ability |
No change |
Morris water maze test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Motor phenotype |
Motor coordination and balance |
No change |
Accelerating rotarod test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Motor phenotype |
General locomotor activity: ambulatory activity |
No change |
Open field test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synaptic morphology: synaptic cleft length |
No change |
Electron microscopy |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synaptic morphology: active zone |
Abnormal |
Electron microscopy |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Somatosensory cortical map architecture |
No change |
Immunohistochemistry |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Post-synaptic density size: inhibitory synapses |
No change |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Post-synaptic density size: excitatory synapses |
No change |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Post-synaptic density size |
No change |
Electron microscopy |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuroreceptor levels: glutamate receptors: nmda receptors |
No change |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuroreceptor levels: glutamate receptors: ampa receptors |
Decreased |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Morphology of the basal ganglia: striatum: caudoputamen |
No change |
Immunohistochemistry |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Hippocampal morphology |
No change |
Immunohistochemistry |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine morphology |
Abnormal |
Electron microscopy |
2.5 months |
Xiong GJ et al. (2020)
|
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine density |
Decreased |
Electron microscopy |
2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Synaptic plasticity: hippocampal ltp |
Decreased |
Field potential recordings |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Synaptic plasticity: hippocampal ltd |
Decreased |
Field potential recordings |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Synaptic neuroreceptor ratio (nmdar/ampar) dependent transmission |
No change |
Whole-cell patch clamp |
3-4 weeks |
Xiong GJ et al. (2020)
|
Neurophysiology |
Miniature post synaptic current frequency: inhibitory |
Decreased |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Miniature post synaptic current frequency: excitatory |
Decreased |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Miniature post synaptic current amplitude: inhibitory |
No change |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Miniature post synaptic current amplitude: excitatory |
No change |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Membrane potential |
No change |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Intrinsic membrane properties |
No change |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Epsp-spike relationship |
Decreased |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Neurophysiology |
Action potential property: firing rate |
No change |
Whole-cell patch clamp |
2-2.5 months |
Xiong GJ et al. (2020)
|
Repetitive behavior |
Self grooming: perseveration |
Increased |
Grooming behavior assessments |
2-2.5 months |
Xiong GJ et al. (2020)
|
Sensory |
Sensorimotor gating |
No change |
Prepulse inhibition |
2-2.5 months |
Xiong GJ et al. (2020)
|
Sensory |
Olfaction |
No change |
Buried food test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Social behavior |
Social memory |
Decreased |
Three-chamber social approach test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Social behavior |
Social habituation |
No change |
Habituation-dishabituation test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Social behavior |
Social dishabituation |
Decreased |
Habituation-dishabituation test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Social behavior |
Social approach |
No change |
Three-chamber social approach test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Social behavior |
Aggression |
No change |
Cotton bud biting test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Physiological parameters |
Reproductive function |
No change |
Genotypic ratio of progeny from heterozygous parents |
Adult |
Xiong GJ et al. (2020)
|
Communications |
Ultrasonic vocalization: isolation induced |
Decreased |
Monitoring ultrasonic vocalizations |
P3-12 |
Xiong GJ et al. (2020)
|
Communications |
Ultrasonic vocalization: interaction induced: opposite sex stimulus |
Decreased |
Monitoring ultrasonic vocalizations |
2-2.5 months |
Xiong GJ et al. (2020)
|
Developmental profile |
Size/growth |
Decreased |
Body weight measurement |
3 weeks-adult |
Xiong GJ et al. (2020)
|
Developmental profile |
Mortality/lethality |
No change |
General observations |
Adult |
Xiong GJ et al. (2020)
|
Emotion |
Anxiety |
No change |
Elevated plus maze test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Emotion |
Anxiety |
No change |
Open field test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Spatial working memory |
No change |
Morris water maze test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Spatial reference memory |
Decreased |
Morris water maze test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Olfactory learning and memory |
No change |
Olfactory habituation-dishabituation test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Object recognition memory |
No change |
Novel object recognition test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Cued or contextual fear conditioning: memory of context |
Decreased |
Fear conditioning test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Cued or contextual fear conditioning: extinction |
Decreased |
Fear conditioning test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Learning & memory |
Cognitive flexibility |
Decreased |
Morris water maze test |
2-2.5 months |
Xiong GJ et al. (2020)
|
Molecular profile |
Targeted expression |
Decreased |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|
Molecular profile |
Protein expression: in situ protein expression |
Decreased |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|
Molecular profile |
Protein expression level evidence |
No change |
Western blot |
2.5 months |
Xiong GJ et al. (2020)
|