Genetic Animal Models / TAOK2

TAOK2 TAO kinase 2

Model Species
Mus musculus
Gene Aliases
1110033K02Rik, B230344N16, MAP3K17, PSK, PSK1, TAO1, TAO2, mKIAA0881
Reports
1
Associated Human Genes
TAOK2
Models / Rescue Models
5 / 3
Rescue Model
-
Model Summary

C57BL6/J Taok2 HT and HM KO mice exhibit abnormal brain morphology, increased brain volume, reduced volume of somatosensory cortex, reduced cerebral cortex, abnormal morphology and size of the corpus callosum, increased ambulation, decreased anxiety, decreased social approach, decreased basal dendrite arborization in the PFC, abnormal spine morphology, decreased synapse number, decreased excitatory neurotransmission, and decreased RhoA activation (Richter M, et al, Mol. Psych., 2018).

External Links
Entrez GeneMouse Genome InformaticsAllen Brain Atlas
Reports related to TAOK2 (1 Reports)
# Type Title Author, Year
1 Primary Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling. Richter M , et al. (2018)
Show all Construct Details Show all Phenotypic Profiles

M_TAOK2_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Taok2 homozygous knockout mice were generated through Cre mediated deletion of lox P sites within the first and seventh introns of the Taok2 gene. C57BL/6Jtyrc-2Jmice carry a recessive point mutation in the tyrosinase gene resulting in a white coat color, allowing the distinction of targeted cells that confer a black coat color. .

Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL

Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Richter M , et al. (2018)
Motor phenotype Swimming ability No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity Increased Open field test 2-2.5 months Richter M , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No change Three-chamber social approach test: modifed 2-2.5 months Richter M , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No change Object-place recognition test 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Decreased Electron microscopy 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunostaining 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum No change Diffusion Tensor imaging (DTI): Diffusion Tensor imaging (DTI) 1 week, 1 month, 4 months, 13 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Diffusion Tensor imaging (DTI): Diffusion Tensor imaging (DTI) 4 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Abnormal Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No change Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity No change Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunostaining 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Decreased Immunostaining 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Magnetic resonance imaging (MRI) 4 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Magnetic resonance imaging (MRI) 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Magnetic resonance imaging (MRI) 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Anatomical projections and connectivity Increased In vivo local field potential (LFP) recordings P8-10 Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current frequency: inhibitory No change Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Local field potential No change In vivo local field potential (LFP) recordings P8-10 Richter M , et al. (2018)
Neurophysiology Local field potential Decreased In vivo local field potential (LFP) recordings P8-10 Richter M , et al. (2018)
Neurophysiology Intrinsic bursting events or spikes Increased In vivo local field potential (LFP) recordings P8-10 Richter M , et al. (2018)
Repetitive behavior - Not Reported - - Richter M , et al. (2018)
Seizure - Not Reported - - Richter M , et al. (2018)
Sensory - Not Reported - - Richter M , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test: modifed 2-2.5 months Richter M , et al. (2018)
Communications - Not Reported - - Richter M , et al. (2018)
Developmental profile Size/growth Decreased Body weight measurement P7-10 Richter M , et al. (2018)
Emotion Thigmotaxis No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Emotion Exploratory activity: Habituation Decreased Open field test 2-2.5 months Richter M , et al. (2018)
Emotion Anxiety Decreased Open field test 2-2.5 months Richter M , et al. (2018)
Emotion Anxiety Decreased Elevated plus maze test 2-2.5 months Richter M , et al. (2018)
Homeostasis - Not Reported - - Richter M , et al. (2018)
Immune response - Not Reported - - Richter M , et al. (2018)
Learning & memory Swim distance No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial working memory Increased Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial working memory Decreased Y-maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial reference memory Increased Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial learning No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Object recognition memory Decreased Object-place recognition test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context: Long term recall No change Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context: Long term recall Decreased Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context No change Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context Decreased Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Maternal behavior - Not Reported - - Richter M , et al. (2018)
Molecular profile Targeted expression Decreased Western blot 3 weeks Richter M , et al. (2018)
Molecular profile Protein expression level evidence Increased Western blot 2-2.5 months Richter M , et al. (2018)
Molecular profile Enzyme activity Decreased Western blot 2-2.5 months Richter M , et al. (2018)

M_TAOK2_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Taok2 heterozygous knockout mice were generated through Cre mediated deletion of lox P sites within the first and seventh introns of the Taok2 gene. C57BL/6Jtyrc-2Jmice carry a recessive point mutation in the tyrosinase gene resulting in a white coat color, allowing the distinction of targeted cells that confer a black coat color. .

Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL

Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Richter M , et al. (2018)
Motor phenotype Swimming ability No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No change Object-place recognition test 2-2.5 months Richter M , et al. (2018)
Motor phenotype General locomotor activity: Ambulatory activity No change Open field test 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunostaining 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum No change Diffusion Tensor imaging (DTI): Diffusion Tensor imaging (DTI) 1 week, 1 month, 4 months, 13 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology and size of the corpus callosum Decreased Diffusion Tensor imaging (DTI): Diffusion Tensor imaging (DTI) 4 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Abnormal Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density No change Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Immunostaining 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Decreased Immunostaining 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Magnetic resonance imaging (MRI) 2-2.5 months Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Magnetic resonance imaging (MRI) 2-2.5 months Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current frequency: inhibitory No change Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current frequency: excitatory Decreased Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Whole-cell patch clamp 3-4 weeks Richter M , et al. (2018)
Repetitive behavior - Not Reported - - Richter M , et al. (2018)
Seizure - Not Reported - - Richter M , et al. (2018)
Sensory - Not Reported - - Richter M , et al. (2018)
Social behavior Social approach No change Three-chamber social approach test: modifed 2-2.5 months Richter M , et al. (2018)
Communications - Not Reported - - Richter M , et al. (2018)
Developmental profile - Not Reported - - Richter M , et al. (2018)
Emotion Thigmotaxis No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 2-2.5 months Richter M , et al. (2018)
Emotion Anxiety Decreased Elevated plus maze test 2-2.5 months Richter M , et al. (2018)
Emotion Anxiety No change Open field test 2-2.5 months Richter M , et al. (2018)
Homeostasis - Not Reported - - Richter M , et al. (2018)
Immune response - Not Reported - - Richter M , et al. (2018)
Learning & memory Swim distance No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial working memory No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial working memory No change Y-maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Spatial reference memory No change Morris water maze test 2-2.5 months Richter M , et al. (2018)
Learning & memory Object recognition memory No change Object-place recognition test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context: Long term recall No change Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context: Long term recall Decreased Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context No change Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Learning & memory Cued or contextual fear conditioning: Memory of context Increased Fear conditioning test 2-2.5 months Richter M , et al. (2018)
Maternal behavior - Not Reported - - Richter M , et al. (2018)
Molecular profile Targeted expression Decreased Western blot 3 weeks Richter M , et al. (2018)
Molecular profile Protein phosphorylation Decreased Western blot 3 weeks Richter M , et al. (2018)

M_TAOK2_2_KO_HT_TAOK2ab-A135P

Model Type: RESCUE-Genetic
Model Genotype: Heterozygous

Mutation:

In utero electroporation of Venus-GFP together with TAOK2α/β A135P (the patient possesses the mutation in both isoforms) in Taok2 Het mice. .

Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL

Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Richter M , et al. (2018)
Motor phenotype - Not Reported - - Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic thickness Side effect Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neurophysiology - Not Reported - - Richter M , et al. (2018)
Repetitive behavior - Not Reported - - Richter M , et al. (2018)
Seizure - Not Reported - - Richter M , et al. (2018)
Sensory - Not Reported - - Richter M , et al. (2018)
Social behavior - Not Reported - - Richter M , et al. (2018)
Communications - Not Reported - - Richter M , et al. (2018)
Developmental profile - Not Reported - - Richter M , et al. (2018)
Emotion - Not Reported - - Richter M , et al. (2018)
Homeostasis - Not Reported - - Richter M , et al. (2018)
Immune response - Not Reported - - Richter M , et al. (2018)
Learning & memory - Not Reported - - Richter M , et al. (2018)
Maternal behavior - Not Reported - - Richter M , et al. (2018)
Molecular profile - Not Reported - - Richter M , et al. (2018)

M_TAOK2_2_KO_HT_TAOK2b-P1022

Model Type: RESCUE-Genetic
Model Genotype: Heterozygous

Mutation:

In utero electroporation of Venus-GFP together with TAOK2β P1022* (the patient only expresses the mutation in the β-isoform) in Taok2 Het mice. .

Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL

Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Richter M , et al. (2018)
Motor phenotype - Not Reported - - Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Restored Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic thickness Side effect Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neurophysiology - Not Reported - - Richter M , et al. (2018)
Repetitive behavior - Not Reported - - Richter M , et al. (2018)
Seizure - Not Reported - - Richter M , et al. (2018)
Sensory - Not Reported - - Richter M , et al. (2018)
Social behavior - Not Reported - - Richter M , et al. (2018)
Communications - Not Reported - - Richter M , et al. (2018)
Developmental profile - Not Reported - - Richter M , et al. (2018)
Emotion - Not Reported - - Richter M , et al. (2018)
Homeostasis - Not Reported - - Richter M , et al. (2018)
Immune response - Not Reported - - Richter M , et al. (2018)
Learning & memory - Not Reported - - Richter M , et al. (2018)
Maternal behavior - Not Reported - - Richter M , et al. (2018)
Molecular profile Targeted expression Refractory Western blot 2-2.5 months Richter M , et al. (2018)

M_TAOK2_2_KO_HT_WT-TAOK2ab

Model Type: RESCUE-Genetic
Model Genotype: Heterozygous

Mutation:

In utero electroporation of Venus-GFP together with WT TAOK2alpha/beta at E15 to transfect neural progenitor cells that produce layer 2/ 3 somatosensory cortical excitatory neurons. .

Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL

Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Richter M , et al. (2018)
Motor phenotype - Not Reported - - Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine morphology Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Refractory Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Ameliorated Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic thickness Side effect Golgi-Cox staining 3 weeks Richter M , et al. (2018)
Neurophysiology - Not Reported - - Richter M , et al. (2018)
Repetitive behavior - Not Reported - - Richter M , et al. (2018)
Seizure - Not Reported - - Richter M , et al. (2018)
Sensory - Not Reported - - Richter M , et al. (2018)
Social behavior - Not Reported - - Richter M , et al. (2018)
Communications - Not Reported - - Richter M , et al. (2018)
Developmental profile - Not Reported - - Richter M , et al. (2018)
Emotion - Not Reported - - Richter M , et al. (2018)
Homeostasis - Not Reported - - Richter M , et al. (2018)
Immune response - Not Reported - - Richter M , et al. (2018)
Learning & memory - Not Reported - - Richter M , et al. (2018)
Maternal behavior - Not Reported - - Richter M , et al. (2018)
Molecular profile - Not Reported - - Richter M , et al. (2018)
Other TAOK2 Rescue Models(3 Models)
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M_TAOK2_2_KO_HT 1 Genetic Genetic TAOK2ab-A135P
M_TAOK2_2_KO_HT 1 Genetic Genetic TAOK2b-P1022
M_TAOK2_2_KO_HT 1 Genetic Genetic WT-TAOK2ab
CNVs associated with TAOK2(1 Models)
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16p11.2 106 Deletion-Duplication 169  /  1535
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