TAOK2 TAO kinase 2
Model Species
Mus musculusGene Aliases
1110033K02Rik, B230344N16, MAP3K17, PSK, PSK1, TAO1, TAO2, mKIAA0881Models / Rescue Models
12 / 6Rescue Model
-Model Summary
C57BL6/J Taok2 HT and HM KO mice exhibit abnormal brain morphology, increased brain volume, reduced volume of somatosensory cortex, reduced cerebral cortex, abnormal morphology and size of the corpus callosum, increased ambulation, decreased anxiety, decreased social approach, decreased basal dendrite arborization in the PFC, abnormal spine morphology, decreased synapse number, decreased excitatory neurotransmission, and decreased RhoA activation (Richter M, et al, Mol. Psych., 2018).
External Links
Reports related to TAOK2 (2 Reports)
| # | Type | Title | Author, Year |
|---|---|---|---|
| 1 | Primary | Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling. | Richter M , et al. (2018) |
| 2 | Additional | TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model | Scharrenberg R et al. (2022) |
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Show all Phenotypic Profiles
M_TAOK2_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Taok2 homozygous knockout mice were generated through Cre mediated deletion of lox P sites within the first and seventh introns of the Taok2 gene. C57BL/6Jtyrc-2Jmice carry a recessive point mutation in the tyrosinase gene resulting in a white coat color, allowing the distinction of targeted cells that confer a black coat color. .
Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL
Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Motor phenotype | Swimming ability | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 2-2.5 months | Richter M , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Object-place recognition test | 2-2.5 months | Richter M , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Three-chamber social approach test | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Decreased | Electron microscopy | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology | No change | Immunostaining | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology and size of the corpus callosum | No change | Diffusion tensor imaging (dti) | 1 week, 1 month, 4 months, 13 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology and size of the corpus callosum | Decreased | Diffusion tensor imaging (dti) | 4 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Abnormal | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No change | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | No change | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | Decreased | Immunostaining | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical lamination | Decreased | Immunostaining | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Magnetic resonance imaging (mri) | 4 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Magnetic resonance imaging (mri) | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Magnetic resonance imaging (mri) | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Anatomical projections and connectivity | Increased | In vivo local field potential (lfp) recordings | P8-10 | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current frequency: inhibitory | No change | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current frequency: excitatory | Decreased | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Local field potential | No change | In vivo local field potential (lfp) recordings | P8-10 | Richter M , et al. (2018) |
| Neurophysiology | Local field potential | Decreased | In vivo local field potential (lfp) recordings | P8-10 | Richter M , et al. (2018) |
| Neurophysiology | Intrinsic bursting events or spikes | Increased | In vivo local field potential (lfp) recordings | P8-10 | Richter M , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-2.5 months | Richter M , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Developmental profile | Size/growth | Decreased | Body weight measurement | P7-10 | Richter M , et al. (2018) |
| Emotion | Thigmotaxis | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Emotion | Exploratory activity: habituation | Decreased | Open field test | 2-2.5 months | Richter M , et al. (2018) |
| Emotion | Anxiety | Decreased | Open field test | 2-2.5 months | Richter M , et al. (2018) |
| Emotion | Anxiety | Decreased | Elevated plus maze test | 2-2.5 months | Richter M , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Learning & memory | Swim distance | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial working memory | Increased | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial working memory | Decreased | Y-maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial reference memory | Increased | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial learning | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Object recognition memory | Decreased | Object-place recognition test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context: long term recall | No change | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context: long term recall | Decreased | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Decreased | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Western blot | 3 weeks | Richter M , et al. (2018) |
| Molecular profile | Protein expression level evidence | Increased | Western blot | 2-2.5 months | Richter M , et al. (2018) |
| Molecular profile | Enzyme activity | Decreased | Western blot | 2-2.5 months | Richter M , et al. (2018) |
M_TAOK2_2_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Taok2 heterozygous knockout mice were generated through Cre mediated deletion of lox P sites within the first and seventh introns of the Taok2 gene. C57BL/6Jtyrc-2Jmice carry a recessive point mutation in the tyrosinase gene resulting in a white coat color, allowing the distinction of targeted cells that confer a black coat color. .
Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL
Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Motor phenotype | Swimming ability | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Object-place recognition test | 2-2.5 months | Richter M , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology | No change | Immunostaining | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology and size of the corpus callosum | No change | Diffusion tensor imaging (dti) | 1 week, 1 month, 4 months, 13 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Morphology and size of the corpus callosum | Decreased | Diffusion tensor imaging (dti) | 4 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Abnormal | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | No change | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Decreased | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | Decreased | Immunostaining | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical lamination | Decreased | Immunostaining | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Increased | Magnetic resonance imaging (mri) | 2-2.5 months | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Magnetic resonance imaging (mri) | 2-2.5 months | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current frequency: inhibitory | No change | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current frequency: excitatory | Decreased | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Neurophysiology | Miniature post synaptic current amplitude: excitatory | No change | Whole-cell patch clamp | 3-4 weeks | Richter M , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Social behavior | Social approach | No change | Three-chamber social approach test | 2-2.5 months | Richter M , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Emotion | Thigmotaxis | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Emotion | Anxiety | No change | Elevated plus maze test | 2-2.5 months | Richter M , et al. (2018) |
| Emotion | Anxiety | Decreased | Elevated plus maze test | 2-2.5 months | Richter M , et al. (2018) |
| Emotion | Anxiety | No change | Open field test | 2-2.5 months | Richter M , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Learning & memory | Swim distance | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial working memory | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial working memory | No change | Y-maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Spatial reference memory | No change | Morris water maze test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Object recognition memory | No change | Object-place recognition test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context: long term recall | No change | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context: long term recall | Decreased | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | No change | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Learning & memory | Cued or contextual fear conditioning: memory of context | Increased | Fear conditioning test | 2-2.5 months | Richter M , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Western blot | 3 weeks | Richter M , et al. (2018) |
| Molecular profile | Protein phosphorylation | Decreased | Western blot | 3 weeks | Richter M , et al. (2018) |
M_TAOK2_2_KO_HT_TAOK2AB-A135P
Model Type: RESCUE-Genetic
Model Genotype: Heterozygous
Mutation:
In utero electroporation of Venus-GFP together with TAOK2/ A135P (the patient possesses the mutation in both isoforms) in Taok2 Het mice. .
Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL
Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Motor phenotype | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic thickness | Side effect | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Social behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Molecular profile | NA | Not reported | NA | NA | Richter M , et al. (2018) |
M_TAOK2_2_KO_HT_TAOK2B-P1022
Model Type: RESCUE-Genetic
Model Genotype: Heterozygous
Mutation:
In utero electroporation of Venus-GFP together with TAOK2 P1022* (the patient only expresses the mutation in the -isoform) in Taok2 Het mice. .
Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL
Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Motor phenotype | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Restored | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic thickness | Side effect | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Social behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Molecular profile | Targeted expression | Refractory | Western blot | 2-2.5 months | Richter M , et al. (2018) |
M_TAOK2_2_KO_HT_WT-TAOK2AB
Model Type: RESCUE-Genetic
Model Genotype: Heterozygous
Mutation:
In utero electroporation of Venus-GFP together with WT TAOK2alpha/beta at E15 to transfect neural progenitor cells that produce layer 2/ 3 somatosensory cortical excitatory neurons. .
Allele Type: knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL/6 * C57BL/6NTac * SJL
Es cell line: -
Model Source: MGI:5554941
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Motor phenotype | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine morphology | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Refractory | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Ameliorated | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic thickness | Side effect | Golgi-cox staining | 3 weeks | Richter M , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Social behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Richter M , et al. (2018) |
| Molecular profile | NA | Not reported | NA | NA | Richter M , et al. (2018) |
M_TAOK2_3_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 7. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 7.
Allele Type: Knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL6/J
Es cell line: PRX-B6N
Model Source: Kapfhammer
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Fluorescence microscopy | 3 weeks | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Time-lapse fluorescence microscopy | E18 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Fluorescence microscopy | E18-E19 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology: size | Decreased | Magnetic resonance imaging (MRI) | P8- 52 weeks | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical thickness | Decreased | Histology | E18 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical lamination | No change | Immunohistochemistry | 3, 16 weeks | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain cytoarchitecture | No change | Immunohistochemistry | E16 | Scharrenberg R et al. (2022) |
M_TAOK2_3_KO_HM_MKK7-JNK1
Model Type: RESCUE-Genetic
Model Genotype: Homozygous
Mutation:
A constitutively active form of JNK1 (MKK7-JNK1) was introduced via in utero electroporation at E15 into cortices of Taok2 knockout mice cortices.
Allele Type: Knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL6/J
Es cell line: PRX-B6N
Model Source: Kapfhammer
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Restored | Fluorescence microscopy | E19 | Scharrenberg R et al. (2022) |
M_TAOK2_4_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 7. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 7.
Allele Type: Knockout
Strain of Origin: C57BL/6NTac
Genetic Background: C57BL6/J
Es cell line: PRX-B6N
Model Source: Kapfhammer
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | No change | Fluorescence microscopy | 3 weeks | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Time-lapse fluorescence microscopy | E18 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Fluorescence microscopy | E18-E19 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neocortex morphology: size | Decreased | Magnetic resonance imaging (MRI) | P8- 52 weeks | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Cortical lamination | No change | Immunohistochemistry | 3, 16 weeks | Scharrenberg R et al. (2022) |
M_TAOK2_5_KD
Model Type: Genetic
Model Genotype: Wildtype
Mutation:
The Taok2 shRNA sequence was inserted into a pSilencer vector. A pSilencer vector containing a random sequence hairpin insert was used as a control for the shRNA. For acute Taok2 downregulation, mouse embryos were electroporated bilaterally in utero. The left hemisphere was electroporated at E15 with Taok2 shRNA and Venus plasmid, while the right hemisphere was electroporated with control shRNA together with mCherry plasmid.
Allele Type: Knockdown
Strain of Origin: -
Genetic Background: C57BL6/J
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal morphology | Abnormal | Fluorescence microscopy | E18-E19 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Time-lapse fluorescence microscopy | E18 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Fluorescence microscopy | P7 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Immunohistochemistry | E16 | Scharrenberg R et al. (2022) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Fluorescence microscopy | E18-E19 | Scharrenberg R et al. (2022) |
M_TAOK2_5_KD_MKK7-JNK1
Model Type: RESCUE-Genetic
Model Genotype: Wildtype
Mutation:
A constitutively active form of JNK1 (MKK7-JNK1) was introduced via in utero electroporation at E15 into cortices of wildtype cortices expressing Taok2 shRNA.
Allele Type: Knockdown
Strain of Origin: -
Genetic Background: C57BL6/J
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Restored | Fluorescence microscopy | E19 | Scharrenberg R et al. (2022) |
M_TAOK2_6_KI_A135P
Model Type: Genetic
Model Genotype: Transgenic
Mutation:
Human-derived mutations in TAOK2 were generated by site-directed mutagenesis. cDNA sequences of wildtype or mutated TAOK2 were re-cloned into a recombinant adeno-associated virus (rAAV)-vector under control of a chicken beta-actin promoter (pCAGIG). TAOK2 mutation construct together with a Venus-expressing plasmid were introduced into cortical progenitor cells by in utero electroporation at E15 to analyze upper-layer neurons.
Allele Type: ASD mutation
Strain of Origin: -
Genetic Background: C57BL6/J
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Decreased | Fluorescence microscopy | E19 | Scharrenberg R et al. (2022) |
M_TAOK2_6_KI_A135P_MKK7-JNK1
Model Type: RESCUE-Genetic
Model Genotype: Transgenic
Mutation:
A constitutively active form of JNK1 (MKK7-JNK1) was introduced via in utero electroporation at E15 into cortices of wildtype cortices expressing TAOK2alphaA135P and harvested transfected brains at E19.
Allele Type: ASD mutation
Strain of Origin: -
Genetic Background: C57BL6/J
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal migration | Restored | Fluorescence microscopy | E19 | Scharrenberg R et al. (2022) |
Other TAOK2 Rescue Models(6 Models)
| M_TAOK2_2_KO_HT | 1 | Genetic | Genetic | TAOK2ab-A135P |
| M_TAOK2_2_KO_HT | 1 | Genetic | Genetic | TAOK2b-P1022 |
| M_TAOK2_2_KO_HT | 1 | Genetic | Genetic | WT-TAOK2ab |
| M_TAOK2_3_KO_HM | 1 | Genetic | Genetic | MKK7-JNK1 |
| M_TAOK2_5_KD | 1 | Genetic | Genetic | MKK7-JNK1 |
| M_TAOK2_6_KI_A135P | 1 | Genetic | Genetic | MKK7-JNK1 |
CNVs associated with TAOK2(1 Models)
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| 16p11.2 | 139 | Deletion-Duplication | 206 / 1636 |