Inbred Animal Models / BTBR

BTBR

Model Species
Mus musculus
Strain Name
BTBR T+ Itpr3tf/J
Reports
29
Inbred Models / Rescue Models
70 / 61
Rescue Model
Yes
Model Summary

The inbred strain BTBR T+ Itpr3tf/J of mice has been used in a 'forward genetics' approach as it was found to have low levels of social interaction. These mice exhibit a 100% absence of corpus callosum and severely reduced hippocampal commissure.

External Links
Reports related to BTBR (29 Reports)
# Type Title Author, Year
1 Primary Autism-like behavioral phenotypes in BTBR T? mice. McFarlane HG , et al. (2007)
2 Additional Social deficits in BTBR T? mice are unchanged by cross-fostering with C57BL/6J mothers. Yang M , et al. (2007)
3 Additional Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Silverman JL , et al. (2009)
4 Additional General and social anxiety in the BTBR T tf/J mouse strain. Pobbe RL , et al. (2010)
5 Additional Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism. Chadman KK (2010)
6 Additional Social peers rescue autism-relevant sociability deficits in adolescent mice. Yang M , et al. (2010)
7 Additional A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T tf/J mice. Defensor EB , et al. (2010)
8 Additional Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T? mouse soc... Gould GG , et al. (2010)
9 Additional Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders. Onaivi ES , et al. (2011)
10 Additional Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Silverman JL , et al. (2012)
11 Additional Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. Gould GG , et al. (2012)
12 Additional Developmental exposure to mercury chloride does not impair social behavior of C57BL/6 BTBR F(1) mice. Zhang Y , et al. (2012)
13 Additional Co-learning facilitates memory in mice: a new avenue in social neuroscience. Lipina TV and Roder JC (2012)
14 Additional AMPAKINE enhancement of social interaction in the BTBR mouse model of autism. Silverman JL , et al. (2012)
15 Additional Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism. Silverman JL , et al. (2012)
16 Additional The maternal autoimmune environment affects the social behavior of offspring. Zhang Y , et al. (2013)
17 Additional D-Cycloserine improves sociability in the BTBR T Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling. Burket JA , et al. (2013)
18 Additional Ketogenic diet improves core symptoms of autism in BTBR mice. Ruskin DN , et al. (2013)
19 Additional Cued and contextual fear conditioning in BTBR mice is improved with training or atomoxetine. Stapley NW , et al. (2013)
20 Additional Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. Karvat G and Kimchi T (2013)
21 Additional Rapamycin improves sociability in the BTBR T()Itpr3(tf)/J mouse model of autism spectrum disorders. Burket JA , et al. (2013)
22 Additional Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism. Seese RR , et al. (2014)
23 Additional Enhancement of inhibitory neurotransmission by GABAA receptors having 2,3-subunits ameliorates behavioral deficits in a mouse model of autism. Han S , et al. (2014)
24 Additional Risperidone and the 5-HT2A receptor antagonist M100907 improve probabilistic reversal learning in BTBR T tf/J mice. Amodeo DA , et al. (2014)
25 Additional Sensory integration in mouse insular cortex reflects GABA circuit maturation. Gogolla N , et al. (2014)
26 Additional Enhanced synapse remodelling as a common phenotype in mouse models of autism. Isshiki M , et al. (2014)
27 Additional Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice. Wu J , et al. (2016)
28 Additional Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORt) signaling in a BTBR T Itpr3tf/... Ansari MA , et al. (2017)
29 Additional Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism. Golubeva AV , et al. (2017)
Show all Rescue Paradigms Show all Phenotypic Profiles

M_BTBR_1_Inbred_HM

Model Source:

JAX

Model Type:

Inbred

Strain of Origin:

BTBR

Mutation:

The BTBR T+ Itpr3tf/J strain was derived from the inbred strain BTBR (Black and Tan BRachyury) that carried the mutations at (nonagouti; black and tan), Itpr3tf (inositol 1,4,5-triphosphate receptor 3; tufted), and T (brachyury).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - McFarlane HG , et al. (2007)
Communications - Not Reported - - McFarlane HG , et al. (2007)
Developmental profile - Not Reported - - McFarlane HG , et al. (2007)
Emotion Anxiety Decreased Elevated zero maze test Unreported McFarlane HG , et al. (2007)
Homeostasis - Not Reported - - McFarlane HG , et al. (2007)
Immune response - Not Reported - - McFarlane HG , et al. (2007)
Learning & memory - Not Reported - - McFarlane HG , et al. (2007)
Maternal behavior - Not Reported - - McFarlane HG , et al. (2007)
Molecular profile - Not Reported - - McFarlane HG , et al. (2007)
Motor phenotype General locomotor activity Increased Open field test 3 weeks McFarlane HG , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - McFarlane HG , et al. (2007)
Neurophysiology - Not Reported - - McFarlane HG , et al. (2007)
Repetitive behavior Self Scratching Increased Grooming behavior assessments P18, P28, P38, P60 McFarlane HG , et al. (2007)
Seizure - Not Reported - - McFarlane HG , et al. (2007)
Sensory Olfaction No Change Three-chamber social approach test: social novelty Unreported McFarlane HG , et al. (2007)
Social behavior Juvenile play Decreased Reciprocal social interaction test: juvenile play 3 weeks McFarlane HG , et al. (2007)
Social behavior Self grooming: social context Increased Reciprocal social interaction test: juvenile play 3 weeks McFarlane HG , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks, adult McFarlane HG , et al. (2007)
Social behavior Social memory No Change Three-chamber social approach test: social novelty Unreported McFarlane HG , et al. (2007)
Social behavior Social transmission of food preference Decreased Social transmission of food preference Unreported McFarlane HG , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Yang M , et al. (2007)
Communications - Not Reported - - Yang M , et al. (2007)
Developmental profile - Not Reported - - Yang M , et al. (2007)
Emotion - Not Reported - - Yang M , et al. (2007)
Homeostasis - Not Reported - - Yang M , et al. (2007)
Immune response - Not Reported - - Yang M , et al. (2007)
Learning & memory - Not Reported - - Yang M , et al. (2007)
Maternal behavior - Not Reported - - Yang M , et al. (2007)
Molecular profile - Not Reported - - Yang M , et al. (2007)
Motor phenotype Self grooming: home cage/familiar environment Increased Home cage behavior Adult Yang M , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Yang M , et al. (2007)
Neurophysiology - Not Reported - - Yang M , et al. (2007)
Repetitive behavior - Not Reported - - Yang M , et al. (2007)
Seizure - Not Reported - - Yang M , et al. (2007)
Sensory - Not Reported - - Yang M , et al. (2007)
Social behavior Juvenile play Decreased Reciprocal social interaction test: juvenile play 3 weeks Yang M , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Yang M , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Increased Open field test 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Increased Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Decreased Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)
Circadian sleep/wake cycle - Not Reported - - Pobbe RL , et al. (2010)
Communications - Not Reported - - Pobbe RL , et al. (2010)
Developmental profile - Not Reported - - Pobbe RL , et al. (2010)
Emotion Anxiety Decreased Mouse defense test battery: Forced contact test 14-17 weeks Pobbe RL , et al. (2010)
Emotion Anxiety Decreased Elevated zero maze test 14-17 weeks Pobbe RL , et al. (2010)
Emotion Anxiety Increased Elevated plus maze test 14-17 weeks Pobbe RL , et al. (2010)
Emotion Fear response Increased Mouse defense test battery: Forced contact test 14-17 weeks Pobbe RL , et al. (2010)
Emotion Fear response Increased Mouse defense test battery: Pre-test and Post-test 14-17 weeks Pobbe RL , et al. (2010)
Emotion Fear response Increased Mouse defense test battery: Predator avoidance test 14-17 weeks Pobbe RL , et al. (2010)
Homeostasis - Not Reported - - Pobbe RL , et al. (2010)
Immune response - Not Reported - - Pobbe RL , et al. (2010)
Learning & memory - Not Reported - - Pobbe RL , et al. (2010)
Maternal behavior - Not Reported - - Pobbe RL , et al. (2010)
Molecular profile - Not Reported - - Pobbe RL , et al. (2010)
Motor phenotype - Not Reported - - Pobbe RL , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Pobbe RL , et al. (2010)
Neurophysiology - Not Reported - - Pobbe RL , et al. (2010)
Repetitive behavior - Not Reported - - Pobbe RL , et al. (2010)
Seizure - Not Reported - - Pobbe RL , et al. (2010)
Sensory - Not Reported - - Pobbe RL , et al. (2010)
Social behavior Social approach Decreased Three-chamber social approach test 14-17 weeks Pobbe RL , et al. (2010)
Circadian sleep/wake cycle - Not Reported - - Chadman KK (2010)
Communications - Not Reported - - Chadman KK (2010)
Developmental profile - Not Reported - - Chadman KK (2010)
Emotion Anxiety No Change Elevated plus maze test 8-15 weeks Chadman KK (2010)
Homeostasis - Not Reported - - Chadman KK (2010)
Immune response - Not Reported - - Chadman KK (2010)
Learning & memory - Not Reported - - Chadman KK (2010)
Maternal behavior - Not Reported - - Chadman KK (2010)
Molecular profile - Not Reported - - Chadman KK (2010)
Motor phenotype - Not Reported - - Chadman KK (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Chadman KK (2010)
Neurophysiology - Not Reported - - Chadman KK (2010)
Repetitive behavior - Not Reported - - Chadman KK (2010)
Seizure - Not Reported - - Chadman KK (2010)
Sensory - Not Reported - - Chadman KK (2010)
Social behavior Social approach Decreased Three-chamber social approach test 8-15 weeks Chadman KK (2010)
Social behavior Social memory No Change Three-chamber social approach test: social novelty 8-15 weeks Chadman KK (2010)
Circadian sleep/wake cycle - Not Reported - - Yang M , et al. (2010)
Communications - Not Reported - - Yang M , et al. (2010)
Developmental profile - Not Reported - - Yang M , et al. (2010)
Emotion - Not Reported - - Yang M , et al. (2010)
Homeostasis - Not Reported - - Yang M , et al. (2010)
Immune response - Not Reported - - Yang M , et al. (2010)
Learning & memory - Not Reported - - Yang M , et al. (2010)
Maternal behavior - Not Reported - - Yang M , et al. (2010)
Molecular profile - Not Reported - - Yang M , et al. (2010)
Motor phenotype General locomotor activity No Change Three-chamber social approach test: compartment transitions 6-8 weeks Yang M , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Yang M , et al. (2010)
Neurophysiology - Not Reported - - Yang M , et al. (2010)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 6-8 weeks Yang M , et al. (2010)
Seizure - Not Reported - - Yang M , et al. (2010)
Sensory - Not Reported - - Yang M , et al. (2010)
Social behavior Social approach Decreased Three-chamber social approach test 6-8 weeks Yang M , et al. (2010)
Circadian sleep/wake cycle - Not Reported - - Defensor EB , et al. (2010)
Communications - Not Reported - - Defensor EB , et al. (2010)
Developmental profile - Not Reported - - Defensor EB , et al. (2010)
Emotion Anxiety Increased Reciprocal social interaction test: jump escape behavior 12-14 weeks Defensor EB , et al. (2010)
Homeostasis - Not Reported - - Defensor EB , et al. (2010)
Immune response - Not Reported - - Defensor EB , et al. (2010)
Learning & memory - Not Reported - - Defensor EB , et al. (2010)
Maternal behavior - Not Reported - - Defensor EB , et al. (2010)
Molecular profile - Not Reported - - Defensor EB , et al. (2010)
Motor phenotype - Not Reported - - Defensor EB , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Defensor EB , et al. (2010)
Neurophysiology - Not Reported - - Defensor EB , et al. (2010)
Repetitive behavior - Not Reported - - Defensor EB , et al. (2010)
Seizure - Not Reported - - Defensor EB , et al. (2010)
Sensory - Not Reported - - Defensor EB , et al. (2010)
Social behavior Rearing behavior Decreased Reciprocal social interaction test 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social approach Decreased Three-chamber social approach test: sociability 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Decreased Reciprocal social interaction test: Nose tip-to-nose tip contact 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Decreased Reciprocal social interaction test: Nose-to-head contact 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Increased Reciprocal social interaction test: no. of crawl overs 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Increased Reciprocal social interaction test: Nose-to-anogenital contact 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social withdrawal Increased Reciprocal social interaction test: crawl under behavior 12-14 weeks Defensor EB , et al. (2010)
Circadian sleep/wake cycle - Not Reported - - Gould GG , et al. (2010)
Communications - Not Reported - - Gould GG , et al. (2010)
Developmental profile - Not Reported - - Gould GG , et al. (2010)
Emotion - Not Reported - - Gould GG , et al. (2010)
Homeostasis - Not Reported - - Gould GG , et al. (2010)
Immune response - Not Reported - - Gould GG , et al. (2010)
Learning & memory - Not Reported - - Gould GG , et al. (2010)
Maternal behavior - Not Reported - - Gould GG , et al. (2010)
Molecular profile Protein binding Increased Agonist-stimulated G-protein coupling assay 4 months Gould GG , et al. (2010)
Molecular profile Protein binding No Change Agonist-stimulated G-protein coupling assay 4 months Gould GG , et al. (2010)
Molecular profile Protein binding: Bmax of receptor Decreased Receptor saturation binding assay: serotonin transporter 4 months Gould GG , et al. (2010)
Molecular profile Protein binding: KD of receptor Increased Receptor saturation binding assay: serotonin transporter 4 months Gould GG , et al. (2010)
Motor phenotype - Not Reported - - Gould GG , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: serotonin No Change Radial maze test: 5HT1 A receptor expression 8-OH DPAT binding Unreported Gould GG , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: serotonin No Change Radial maze test: 5HT2 A receptor expression ketanserin binding Unreported Gould GG , et al. (2010)
Neurophysiology Neurotransporter activity Decreased Radial maze test: serotonin transporter density 4 months Gould GG , et al. (2010)
Neurophysiology Neurotransporter activity No Change Radial maze test: serotonin transporter density Unreported Gould GG , et al. (2010)
Repetitive behavior Repetitive digging No Change Marble-burying test 3-4 months Gould GG , et al. (2010)
Seizure - Not Reported - - Gould GG , et al. (2010)
Sensory - Not Reported - - Gould GG , et al. (2010)
Social behavior Social approach Decreased Three-chamber social approach test 3-4 months Gould GG , et al. (2010)
Social behavior Social memory No Change Three-chamber social approach test: social novelty 3-4 months Gould GG , et al. (2010)
Circadian sleep/wake cycle - Not Reported - - Onaivi ES , et al. (2011)
Communications - Not Reported - - Onaivi ES , et al. (2011)
Developmental profile - Not Reported - - Onaivi ES , et al. (2011)
Emotion Depression Increased Forced swim test Adult Onaivi ES , et al. (2011)
Homeostasis - Not Reported - - Onaivi ES , et al. (2011)
Immune response - Not Reported - - Onaivi ES , et al. (2011)
Learning & memory - Not Reported - - Onaivi ES , et al. (2011)
Maternal behavior - Not Reported - - Onaivi ES , et al. (2011)
Molecular profile - Not Reported - - Onaivi ES , et al. (2011)
Motor phenotype General locomotor activity Increased Running wheel test Adult Onaivi ES , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: catecholamines No Change High-performance liquid chromatography (HPLC): striatum and frontal cortex Adult Onaivi ES , et al. (2011)
Repetitive behavior - Not Reported - - Onaivi ES , et al. (2011)
Seizure - Not Reported - - Onaivi ES , et al. (2011)
Sensory - Not Reported - - Onaivi ES , et al. (2011)
Social behavior - Not Reported - - Onaivi ES , et al. (2011)
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion - Not Reported - - Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Increased Home cage behavior 9-10 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior Repetitive digging Increased Three-chamber social approach test 8-16 weeks Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Self grooming: social context Increased Three-chamber social approach test 8-16 weeks Silverman JL , et al. (2012)
Social behavior Social approach Decreased Three-chamber social approach test 9-10 weeks Silverman JL , et al. (2012)
Social behavior Social interaction Decreased Three-chamber social approach test 8-16 weeks Silverman JL , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Gould GG , et al. (2012)
Communications - Not Reported - - Gould GG , et al. (2012)
Developmental profile - Not Reported - - Gould GG , et al. (2012)
Emotion - Not Reported - - Gould GG , et al. (2012)
Homeostasis - Not Reported - - Gould GG , et al. (2012)
Immune response - Not Reported - - Gould GG , et al. (2012)
Learning & memory - Not Reported - - Gould GG , et al. (2012)
Maternal behavior - Not Reported - - Gould GG , et al. (2012)
Molecular profile Protein binding: Bmax of receptor No Change Radioligand binding studies: CB1 receptor Unreported Gould GG , et al. (2012)
Molecular profile Protein binding: KD of receptor No Change Radioligand binding studies: CB1 receptor Unreported Gould GG , et al. (2012)
Molecular profile Protein expression level evidence No Change Radioligand binding studies: 5-HT1a receptor by using 8-OH-DPAT 3-4 months Gould GG , et al. (2012)
Molecular profile Protein expression level evidence No Change Radioligand binding studies: CB1 receptor by using CP55,940 3-4 months Gould GG , et al. (2012)
Molecular profile Protein expression: In situ protein expression Increased Autoradiographic analysis 3-4 months Gould GG , et al. (2012)
Molecular profile Protein expression: In situ protein expression No Change Autoradiographic analysis 3-4 months Gould GG , et al. (2012)
Molecular profile Protein expression: In situ protein expression No Change Autoradiographic analysis 3-4 months Gould GG , et al. (2012)
Motor phenotype - Not Reported - - Gould GG , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gould GG , et al. (2012)
Neurophysiology - Not Reported - - Gould GG , et al. (2012)
Repetitive behavior - Not Reported - - Gould GG , et al. (2012)
Seizure - Not Reported - - Gould GG , et al. (2012)
Sensory - Not Reported - - Gould GG , et al. (2012)
Social behavior Social approach Decreased Three-chamber social approach test 3-4 months Gould GG , et al. (2012)
Social behavior Social memory No Change Three-chamber social approach test 3-4 months Gould GG , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations: object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations: fear conditioning test: contextual 12-14 weeks Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations: fear conditioning test: acoustic cue-dependent 12-14 weeks Lipina TV and Roder JC (2012)
Developmental profile - Not Reported - - Lipina TV and Roder JC (2012)
Emotion Anxiety No Change Elevated plus maze test 12-14 weeks Lipina TV and Roder JC (2012)
Emotion Response to novelty No Change Object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Homeostasis - Not Reported - - Lipina TV and Roder JC (2012)
Immune response - Not Reported - - Lipina TV and Roder JC (2012)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test: contextual 12-14 weeks Lipina TV and Roder JC (2012)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test: acoustic cue-dependent 12-14 weeks Lipina TV and Roder JC (2012)
Learning & memory Object recognition memory Decreased Object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Maternal behavior - Not Reported - - Lipina TV and Roder JC (2012)
Molecular profile - Not Reported - - Lipina TV and Roder JC (2012)
Motor phenotype General locomotor activity Increased Open field test 12-14 weeks Lipina TV and Roder JC (2012)
Motor phenotype General locomotor activity Increased Object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Motor phenotype Hyperactivity Increased Elevated plus maze test 12-14 weeks Lipina TV and Roder JC (2012)
Motor phenotype Self grooming: home cage/familiar environment Increased Object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Lipina TV and Roder JC (2012)
Neurophysiology - Not Reported - - Lipina TV and Roder JC (2012)
Repetitive behavior - Not Reported - - Lipina TV and Roder JC (2012)
Seizure - Not Reported - - Lipina TV and Roder JC (2012)
Sensory - Not Reported - - Lipina TV and Roder JC (2012)
Social behavior Rearing behavior No Change Object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations: reciprocal social interaction test: male-female 6-8 weeks Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety Increased Open field test 8 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory Object recognition memory Decreased Novel object recognition test 6-8 weeks Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Increased Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Increased Grooming behavior assessments 7 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks Silverman JL , et al. (2012)
Social behavior Social interaction: opposite sex Decreased Reciprocal social interaction test 6-8 weeks Silverman JL , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety Increased Open field test 6-8 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Decreased Open field test 6-8 weeks Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Increased Open field test 6-8 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Increased Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Social approach Decreased Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Zhang Y , et al. (2013)
Communications - Not Reported - - Zhang Y , et al. (2013)
Developmental profile - Not Reported - - Zhang Y , et al. (2013)
Emotion - Not Reported - - Zhang Y , et al. (2013)
Homeostasis - Not Reported - - Zhang Y , et al. (2013)
Immune response Adaptive immune response: B cells antibody production Increased ELISPOT; ELISA: total IgG Unreported Zhang Y , et al. (2013)
Immune response Adaptive immune response: Leukocyte types Decreased Flow cytometric analysis Unreported Zhang Y , et al. (2013)
Immune response Adaptive immune response: Leukocyte types Increased Flow cytometric analysis Unreported Zhang Y , et al. (2013)
Immune response Adaptive immune response: T cells Increased ELISA; Immune cell culture Unreported Zhang Y , et al. (2013)
Learning & memory - Not Reported - - Zhang Y , et al. (2013)
Maternal behavior - Not Reported - - Zhang Y , et al. (2013)
Molecular profile - Not Reported - - Zhang Y , et al. (2013)
Motor phenotype - Not Reported - - Zhang Y , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Zhang Y , et al. (2013)
Neurophysiology - Not Reported - - Zhang Y , et al. (2013)
Repetitive behavior - Not Reported - - Zhang Y , et al. (2013)
Seizure - Not Reported - - Zhang Y , et al. (2013)
Sensory - Not Reported - - Zhang Y , et al. (2013)
Social behavior - Not Reported - - Zhang Y , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Burket JA , et al. (2013)
Communications - Not Reported - - Burket JA , et al. (2013)
Developmental profile - Not Reported - - Burket JA , et al. (2013)
Emotion - Not Reported - - Burket JA , et al. (2013)
Homeostasis - Not Reported - - Burket JA , et al. (2013)
Immune response - Not Reported - - Burket JA , et al. (2013)
Learning & memory - Not Reported - - Burket JA , et al. (2013)
Maternal behavior - Not Reported - - Burket JA , et al. (2013)
Molecular profile - Not Reported - - Burket JA , et al. (2013)
Motor phenotype General locomotor activity Decreased Compartment transitions in three-chambered apparatus 4 weeks Burket JA , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Burket JA , et al. (2013)
Neurophysiology - Not Reported - - Burket JA , et al. (2013)
Repetitive behavior - Not Reported - - Burket JA , et al. (2013)
Seizure - Not Reported - - Burket JA , et al. (2013)
Sensory - Not Reported - - Burket JA , et al. (2013)
Social behavior Juvenile play Decreased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Rearing behavior Decreased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Self grooming: social context No Change Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social withdrawal Increased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Ruskin DN , et al. (2013)
Communications - Not Reported - - Ruskin DN , et al. (2013)
Developmental profile - Not Reported - - Ruskin DN , et al. (2013)
Emotion - Not Reported - - Ruskin DN , et al. (2013)
Homeostasis - Not Reported - - Ruskin DN , et al. (2013)
Immune response - Not Reported - - Ruskin DN , et al. (2013)
Learning & memory - Not Reported - - Ruskin DN , et al. (2013)
Maternal behavior - Not Reported - - Ruskin DN , et al. (2013)
Molecular profile - Not Reported - - Ruskin DN , et al. (2013)
Motor phenotype - Not Reported - - Ruskin DN , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Ruskin DN , et al. (2013)
Neurophysiology - Not Reported - - Ruskin DN , et al. (2013)
Repetitive behavior - Not Reported - - Ruskin DN , et al. (2013)
Seizure Electroencephalogram (EEG): signature of seizure/epilepsy No Change Electroencephalogram (EEG) 8-10 weeks Ruskin DN , et al. (2013)
Seizure Seizure threshold Decreased Observation of electrically induced seizures 8-10 weeks Ruskin DN , et al. (2013)
Seizure Seizure threshold Increased Observation of chemically induced seizures: maximal Seizure threshold test 8-10 weeks Ruskin DN , et al. (2013)
Seizure Seizure threshold No Change Observation of chemically induced seizures: maximal Seizure threshold test 8-10 weeks Ruskin DN , et al. (2013)
Seizure Seizure threshold No Change Observation of chemically induced seizures: maximal Seizure threshold test 8-10 weeks Ruskin DN , et al. (2013)
Seizure Seizures No Change General observations 8-10 weeks Ruskin DN , et al. (2013)
Sensory - Not Reported - - Ruskin DN , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 8-10 weeks Ruskin DN , et al. (2013)
Social behavior Social memory Decreased Three-chamber social approach test 8-10 weeks Ruskin DN , et al. (2013)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 8-10 weeks Ruskin DN , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Stapley NW , et al. (2013)
Communications - Not Reported - - Stapley NW , et al. (2013)
Developmental profile - Not Reported - - Stapley NW , et al. (2013)
Emotion - Not Reported - - Stapley NW , et al. (2013)
Homeostasis - Not Reported - - Stapley NW , et al. (2013)
Immune response - Not Reported - - Stapley NW , et al. (2013)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test: acoustic cue-dependent 3-7 months Stapley NW , et al. (2013)
Maternal behavior - Not Reported - - Stapley NW , et al. (2013)
Molecular profile - Not Reported - - Stapley NW , et al. (2013)
Motor phenotype - Not Reported - - Stapley NW , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Stapley NW , et al. (2013)
Neurophysiology - Not Reported - - Stapley NW , et al. (2013)
Repetitive behavior - Not Reported - - Stapley NW , et al. (2013)
Seizure - Not Reported - - Stapley NW , et al. (2013)
Sensory - Not Reported - - Stapley NW , et al. (2013)
Social behavior - Not Reported - - Stapley NW , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Karvat G and Kimchi T (2013)
Communications - Not Reported - - Karvat G and Kimchi T (2013)
Developmental profile - Not Reported - - Karvat G and Kimchi T (2013)
Emotion - Not Reported - - Karvat G and Kimchi T (2013)
Homeostasis - Not Reported - - Karvat G and Kimchi T (2013)
Immune response - Not Reported - - Karvat G and Kimchi T (2013)
Learning & memory Cognitive flexibility Decreased Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Maternal behavior - Not Reported - - Karvat G and Kimchi T (2013)
Molecular profile - Not Reported - - Karvat G and Kimchi T (2013)
Motor phenotype - Not Reported - - Karvat G and Kimchi T (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Karvat G and Kimchi T (2013)
Neurophysiology - Not Reported - - Karvat G and Kimchi T (2013)
Repetitive behavior - Not Reported - - Karvat G and Kimchi T (2013)
Seizure - Not Reported - - Karvat G and Kimchi T (2013)
Sensory - Not Reported - - Karvat G and Kimchi T (2013)
Social behavior Social approach Decreased Three-chamber social approach test 8 weeks Karvat G and Kimchi T (2013)
Social behavior Social interaction Decreased Running wheel test: jammed wheel: social interaction 8 weeks Karvat G and Kimchi T (2013)
Social behavior Social memory Decreased Three-chamber social approach test: novel versus familiar animal 8 weeks Karvat G and Kimchi T (2013)
Circadian sleep/wake cycle - Not Reported - - Burket JA , et al. (2013)
Communications - Not Reported - - Burket JA , et al. (2013)
Developmental profile - Not Reported - - Burket JA , et al. (2013)
Emotion - Not Reported - - Burket JA , et al. (2013)
Homeostasis - Not Reported - - Burket JA , et al. (2013)
Immune response - Not Reported - - Burket JA , et al. (2013)
Learning & memory - Not Reported - - Burket JA , et al. (2013)
Maternal behavior - Not Reported - - Burket JA , et al. (2013)
Molecular profile - Not Reported - - Burket JA , et al. (2013)
Motor phenotype General locomotor activity Decreased Three-chamber social approach test: compartment transtions 4 weeks Burket JA , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Burket JA , et al. (2013)
Neurophysiology - Not Reported - - Burket JA , et al. (2013)
Repetitive behavior - Not Reported - - Burket JA , et al. (2013)
Seizure - Not Reported - - Burket JA , et al. (2013)
Sensory - Not Reported - - Burket JA , et al. (2013)
Social behavior Juvenile play No Change Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Rearing behavior Decreased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Self grooming: social context No Change Three-chamber social approach test: self grooming during the test 4 weeks Burket JA , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social interaction Increased Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social withdrawal No Change Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Seese RR , et al. (2014)
Communications - Not Reported - - Seese RR , et al. (2014)
Developmental profile - Not Reported - - Seese RR , et al. (2014)
Emotion - Not Reported - - Seese RR , et al. (2014)
Homeostasis - Not Reported - - Seese RR , et al. (2014)
Immune response - Not Reported - - Seese RR , et al. (2014)
Learning & memory Object recognition memory Decreased Object-place recognition test 4-6 months Seese RR , et al. (2014)
Maternal behavior - Not Reported - - Seese RR , et al. (2014)
Molecular profile Signaling Decreased Fluorescence tomography; Western blot 4-6 months Seese RR , et al. (2014)
Motor phenotype - Not Reported - - Seese RR , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Seese RR , et al. (2014)
Neurophysiology - Not Reported - - Seese RR , et al. (2014)
Repetitive behavior Repetitive digging Increased Object-place recognition test 4-6 months Seese RR , et al. (2014)
Seizure - Not Reported - - Seese RR , et al. (2014)
Sensory - Not Reported - - Seese RR , et al. (2014)
Social behavior - Not Reported - - Seese RR , et al. (2014)
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion Anxiety Decreased Open field test 6-10 months Han S , et al. (2014)
Emotion Anxiety Decreased Elevated plus maze test 6-10 months Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning Decreased Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context Decreased Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Learning & memory Spatial reference memory Decreased Barnes maze test: probe trial 6-10 months Han S , et al. (2014)
Learning & memory Spatial working memory Decreased Barnes maze test: learning during training sessions 6-10 months Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity Increased Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology Miniature post synaptic currents: excitatory Increased Whole-cell patch clamp 3 weeks Han S , et al. (2014)
Neurophysiology Miniature post synaptic currents: inhibitory No Change Whole-cell patch clamp 3 weeks Han S , et al. (2014)
Neurophysiology Synaptic transmission: excitatory No Change Whole-cell patch clamp: slices treated with the drug clonazepam 3 weeks Han S , et al. (2014)
Neurophysiology Synaptic transmission: excitatory Increased Whole-cell patch clamp 3 weeks Han S , et al. (2014)
Neurophysiology Synaptic transmission: inhibitory Decreased Whole-cell patch clamp 3 weeks Han S , et al. (2014)
Neurophysiology Synaptic transmission: inhibitory No Change Whole-cell patch clamp: slices treated with the drug clonazepam 3 weeks Han S , et al. (2014)
Repetitive behavior Circling Increased Open field test 6-10 months Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social approach Decreased Three-chamber social approach test 6-10 months Han S , et al. (2014)
Social behavior Social interaction Decreased Reciprocal social interaction test 6-10 months Han S , et al. (2014)
Circadian sleep/wake cycle - Not Reported - - Amodeo DA , et al. (2014)
Communications - Not Reported - - Amodeo DA , et al. (2014)
Developmental profile - Not Reported - - Amodeo DA , et al. (2014)
Emotion - Not Reported - - Amodeo DA , et al. (2014)
Homeostasis - Not Reported - - Amodeo DA , et al. (2014)
Immune response - Not Reported - - Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Decreased Spatial discrimination assay: reversal learning: time taken to learn and regressive errors 8 weeks Amodeo DA , et al. (2014)
Learning & memory Spatial learning No Change Spatial discrimination assay: acquisition 8 weeks Amodeo DA , et al. (2014)
Maternal behavior - Not Reported - - Amodeo DA , et al. (2014)
Molecular profile - Not Reported - - Amodeo DA , et al. (2014)
Motor phenotype - Not Reported - - Amodeo DA , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amodeo DA , et al. (2014)
Neurophysiology - Not Reported - - Amodeo DA , et al. (2014)
Repetitive behavior Perseveration No Change Spatial discrimination assay: reversal learning: errors 8 weeks Amodeo DA , et al. (2014)
Seizure - Not Reported - - Amodeo DA , et al. (2014)
Sensory - Not Reported - - Amodeo DA , et al. (2014)
Social behavior - Not Reported - - Amodeo DA , et al. (2014)
Circadian sleep/wake cycle - Not Reported - - Gogolla N , et al. (2014)
Communications - Not Reported - - Gogolla N , et al. (2014)
Developmental profile - Not Reported - - Gogolla N , et al. (2014)
Emotion - Not Reported - - Gogolla N , et al. (2014)
Homeostasis - Not Reported - - Gogolla N , et al. (2014)
Immune response - Not Reported - - Gogolla N , et al. (2014)
Learning & memory - Not Reported - - Gogolla N , et al. (2014)
Maternal behavior - Not Reported - - Gogolla N , et al. (2014)
Molecular profile - Not Reported - - Gogolla N , et al. (2014)
Motor phenotype - Not Reported - - Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Perineuronal net morphology Decreased Immunohistochemistry: wisteria floribunda agglutinin (WFA) perineuronal nets Unreported Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: Inhibitory Decreased Immunohistochemistry: GAD65 Unreported Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Decreased Immunohistochemistry: Parvalbumin and NeuN Unreported Gogolla N , et al. (2014)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No Change Whole-cell patch clamp: layer2/3 of pyramidal cells of granular insular cortex Unreported Gogolla N , et al. (2014)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp: layer2/3 of pyramidal cells of granular insular cortex Unreported Gogolla N , et al. (2014)
Neurophysiology Neurotransmitter release: serotonin No Change High-performance liquid chromatography (HPLC): striatum Adult Gogolla N , et al. (2014)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments Adult Gogolla N , et al. (2014)
Seizure - Not Reported - - Gogolla N , et al. (2014)
Sensory Multisensory integration: sensory neurons of insular cortex: auditory-tactile Decreased Application of tactile and auditory cues: pure tones (80dB) and air puffs adminitered to the contralateral fron paw; Quantification of degree of integration Adult Gogolla N , et al. (2014)
Sensory Sensory-evoked response: excitation: auditory stimulus No Change Application of auditory stimuli: pure tone; Measurement of area of activation (ROI) in the insular cortex; Grooming behavior assessments: self grooming Adult Gogolla N , et al. (2014)
Sensory Sensory-evoked response: excitation: auditory stimulus Increased Application of auditory stimuli: pure tone; Measurement of area of activation (ROI) in the insular cortex; Grooming behavior assessments: self grooming Adult Gogolla N , et al. (2014)
Sensory Sensory-evoked response: excitation: auditory stimulus Increased Application of auditory stimuli: pure tone; Measurement of area of activation (ROI) in the insular cortex; Grooming behavior assessments: self grooming P15-P21 Gogolla N , et al. (2014)
Social behavior - Not Reported - - Gogolla N , et al. (2014)
Circadian sleep/wake cycle - Not Reported - - Wu J , et al. (2016)
Communications - Not Reported - - Wu J , et al. (2016)
Developmental profile - Not Reported - - Wu J , et al. (2016)
Emotion - Not Reported - - Wu J , et al. (2016)
Homeostasis - Not Reported - - Wu J , et al. (2016)
Immune response - Not Reported - - Wu J , et al. (2016)
Learning & memory - Not Reported - - Wu J , et al. (2016)
Maternal behavior - Not Reported - - Wu J , et al. (2016)
Molecular profile Protein phosphorylation No Change Western blot 12 weeks Wu J , et al. (2016)
Molecular profile Signaling: mTOR No Change Western blot 12 weeks Wu J , et al. (2016)
Molecular profile Signaling: mTOR Decreased Western blot 12 weeks Wu J , et al. (2016)
Motor phenotype General locomotor activity Increased Open field test 12 weeks Wu J , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Wu J , et al. (2016)
Neurophysiology - Not Reported - - Wu J , et al. (2016)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 12 weeks Wu J , et al. (2016)
Seizure - Not Reported - - Wu J , et al. (2016)
Sensory - Not Reported - - Wu J , et al. (2016)
Social behavior Social interaction Increased Partition test 12 weeks Wu J , et al. (2016)
Social behavior Social interaction No Change Partition test 12 weeks Wu J , et al. (2016)
Circadian sleep/wake cycle - Not Reported - - Ansari MA , et al. (2017)
Communications - Not Reported - - Ansari MA , et al. (2017)
Developmental profile - Not Reported - - Ansari MA , et al. (2017)
Emotion - Not Reported - - Ansari MA , et al. (2017)
Homeostasis - Not Reported - - Ansari MA , et al. (2017)
Immune response Adaptive immune response: T cells Decreased Flow cytometric analysis 11 weeks Ansari MA , et al. (2017)
Immune response Adaptive immune response: T cells Increased Flow cytometric analysis 11 weeks Ansari MA , et al. (2017)
Learning & memory - Not Reported - - Ansari MA , et al. (2017)
Maternal behavior - Not Reported - - Ansari MA , et al. (2017)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) 11 weeks Ansari MA , et al. (2017)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 11 weeks Ansari MA , et al. (2017)
Molecular profile Protein expression level evidence Decreased Western blot 11 weeks Ansari MA , et al. (2017)
Molecular profile Protein expression level evidence Increased Western blot 11 weeks Ansari MA , et al. (2017)
Molecular profile Protein phosphorylation Increased Western blot 11 weeks Ansari MA , et al. (2017)
Motor phenotype - Not Reported - - Ansari MA , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Ansari MA , et al. (2017)
Neurophysiology - Not Reported - - Ansari MA , et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 11 weeks Ansari MA , et al. (2017)
Seizure - Not Reported - - Ansari MA , et al. (2017)
Sensory Pain or nociception Decreased Hot plate test 11 weeks Ansari MA , et al. (2017)
Social behavior - Not Reported - - Ansari MA , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - Golubeva AV , et al. (2017)
Communications - Not Reported - - Golubeva AV , et al. (2017)
Developmental profile Adrenal cortex morphology Abnormal General observations 14 weeks Golubeva AV , et al. (2017)
Emotion Anxiety No change Open field test 9 weeks Golubeva AV , et al. (2017)
Emotion Anxiety Increased Elevated plus maze test 10 weeks Golubeva AV , et al. (2017)
Emotion Anxiety Increased General observations 9-10 weeks Golubeva AV , et al. (2017)
Emotion Depression Abnormal Forced swim test 13 weeks Golubeva AV , et al. (2017)
Homeostasis - Not Reported - - Golubeva AV , et al. (2017)
Immune response - Not Reported - - Golubeva AV , et al. (2017)
Learning & memory Object recognition memory Decreased Novel object recognition test 9 weeks Golubeva AV , et al. (2017)
Maternal behavior - Not Reported - - Golubeva AV , et al. (2017)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) 8 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 8 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression No change Quantitative PCR (qRT-PCR) 8 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression No change Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression Decreased Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Molecular profile Gene expression No change Quantitative PCR (qRT-PCR) 14 weeks Golubeva AV , et al. (2017)
Motor phenotype General locomotor activity: Ambulatory activity Increased Open field test 9 weeks Golubeva AV , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: enteric neurons Abnormal Immunofluorescence staining 14 weeks Golubeva AV , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: enteric neurons Decreased Immunofluorescence staining 14 weeks Golubeva AV , et al. (2017)
Neurophysiology - Not Reported - - Golubeva AV , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test 10 weeks Golubeva AV , et al. (2017)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 8 weeks Golubeva AV , et al. (2017)
Seizure - Not Reported - - Golubeva AV , et al. (2017)
Sensory - Not Reported - - Golubeva AV , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test: social approach 8 weeks Golubeva AV , et al. (2017)
Social behavior Social interaction Decreased Resident-intruder test: social interaction 12 weeks Golubeva AV , et al. (2017)
Social behavior Social memory Decreased Three-chamber social approach test: social novelty 8 weeks Golubeva AV , et al. (2017)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 11 weeks Golubeva AV , et al. (2017)

M_BTBR_1_inbred_HM_Acetaminophen

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with acetaminophen (100 mg/kg in 0.9 % saline)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gould GG , et al. (2012)
Communications - Not Reported - - Gould GG , et al. (2012)
Developmental profile - Not Reported - - Gould GG , et al. (2012)
Emotion - Not Reported - - Gould GG , et al. (2012)
Homeostasis - Not Reported - - Gould GG , et al. (2012)
Immune response - Not Reported - - Gould GG , et al. (2012)
Learning & memory - Not Reported - - Gould GG , et al. (2012)
Maternal behavior - Not Reported - - Gould GG , et al. (2012)
Molecular profile Protein expression level evidence Increased Gas chromatography-mass spectrometry (GC-MS): endogenous cannabinoid AEA 3-4 months Gould GG , et al. (2012)
Molecular profile Protein expression level evidence No Change Gas chromatography-mass spectrometry (GC-MS): endogenous cannabinoid 2AG 3-4 months Gould GG , et al. (2012)
Molecular profile Protein expression level evidence No Change Gas chromatography-mass spectrometry (GC-MS): endogenous cannabinoid OEA 3-4 months Gould GG , et al. (2012)
Motor phenotype - Not Reported - - Gould GG , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gould GG , et al. (2012)
Neurophysiology - Not Reported - - Gould GG , et al. (2012)
Repetitive behavior Repetitive digging Refractory Marble-burying test 3-4 months Gould GG , et al. (2012)
Seizure - Not Reported - - Gould GG , et al. (2012)
Sensory - Not Reported - - Gould GG , et al. (2012)
Social behavior Social approach Ameliorated Three-chamber social approach test 3-4 months Gould GG , et al. (2012)
Social behavior Social memory Side Effect Three-chamber social approach test 3-4 months Gould GG , et al. (2012)

M_BTBR_1_inbred_HM_Amphetamine

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR male mice were i.p. injected with Amphetamine (2.0 mg/kg in saline)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety Refractory Open field test 6-8 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Refractory Open field test 6-8 weeks Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Side Effect Open field test 6-8 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Restored Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Social approach Ameliorated Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2012)

M_BTBR_1_inbred_HM_Amphetamine_2

Model Source:

Not Specified

Model Type:

Pharmaceutical intervention

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with D-amphetamine (5.0 mg/kg) 10 min before testing

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Onaivi ES , et al. (2011)
Communications - Not Reported - - Onaivi ES , et al. (2011)
Developmental profile - Not Reported - - Onaivi ES , et al. (2011)
Emotion - Not Reported - - Onaivi ES , et al. (2011)
Homeostasis - Not Reported - - Onaivi ES , et al. (2011)
Immune response - Not Reported - - Onaivi ES , et al. (2011)
Learning & memory - Not Reported - - Onaivi ES , et al. (2011)
Maternal behavior - Not Reported - - Onaivi ES , et al. (2011)
Molecular profile - Not Reported - - Onaivi ES , et al. (2011)
Motor phenotype General locomotor activity No Change Running wheel test Adult Onaivi ES , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Onaivi ES , et al. (2011)
Neurophysiology - Not Reported - - Onaivi ES , et al. (2011)
Repetitive behavior - Not Reported - - Onaivi ES , et al. (2011)
Seizure - Not Reported - - Onaivi ES , et al. (2011)
Sensory - Not Reported - - Onaivi ES , et al. (2011)
Social behavior - Not Reported - - Onaivi ES , et al. (2011)

M_BTBR_1_inbred_HM_atomoxetine

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR male mice were i.p. injected with atomoxetine (2 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Stapley NW , et al. (2013)
Communications - Not Reported - - Stapley NW , et al. (2013)
Developmental profile - Not Reported - - Stapley NW , et al. (2013)
Emotion - Not Reported - - Stapley NW , et al. (2013)
Homeostasis - Not Reported - - Stapley NW , et al. (2013)
Immune response - Not Reported - - Stapley NW , et al. (2013)
Learning & memory Cued or contextual fear conditioning Ameliorated Fear conditioning test: contextual 3-7 months Stapley NW , et al. (2013)
Learning & memory Cued or contextual fear conditioning Refractory Fear conditioning test: acoustic cue-dependent 3-7 months Stapley NW , et al. (2013)
Maternal behavior - Not Reported - - Stapley NW , et al. (2013)
Molecular profile - Not Reported - - Stapley NW , et al. (2013)
Motor phenotype - Not Reported - - Stapley NW , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Stapley NW , et al. (2013)
Neurophysiology - Not Reported - - Stapley NW , et al. (2013)
Repetitive behavior - Not Reported - - Stapley NW , et al. (2013)
Seizure - Not Reported - - Stapley NW , et al. (2013)
Sensory - Not Reported - - Stapley NW , et al. (2013)
Social behavior - Not Reported - - Stapley NW , et al. (2013)

M_BTBR_1_inbred_HM_BlastoTrans

Model Source:

JAX

Model Type:

RESCUE-Transplantation

Strain of Origin:

BTBR

Mutation:

BTBR embryos (3.5 dpc, BTBR) are transferred to the uterus of 2.5 dpc pseudopregnant recipient females (C57BL/6J)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Zhang Y , et al. (2013)
Communications - Not Reported - - Zhang Y , et al. (2013)
Developmental profile - Not Reported - - Zhang Y , et al. (2013)
Emotion - Not Reported - - Zhang Y , et al. (2013)
Homeostasis - Not Reported - - Zhang Y , et al. (2013)
Immune response Adaptive immune response: B cells antibody production: IgG Refractory ELISA: anti brain IgG; ELISA 10 weeks Zhang Y , et al. (2013)
Learning & memory - Not Reported - - Zhang Y , et al. (2013)
Maternal behavior - Not Reported - - Zhang Y , et al. (2013)
Molecular profile - Not Reported - - Zhang Y , et al. (2013)
Motor phenotype - Not Reported - - Zhang Y , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Zhang Y , et al. (2013)
Neurophysiology - Not Reported - - Zhang Y , et al. (2013)
Repetitive behavior - Not Reported - - Zhang Y , et al. (2013)
Seizure - Not Reported - - Zhang Y , et al. (2013)
Sensory - Not Reported - - Zhang Y , et al. (2013)
Social behavior Self grooming: social context Ameliorated Three-chamber social approach test 10 weeks Zhang Y , et al. (2013)
Social behavior Social approach Restored Three-chamber social approach test 10 weeks Zhang Y , et al. (2013)

M_BTBR_1_inbred_HM_buspirone

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with buspirone (2 mg/kg) before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gould GG , et al. (2010)
Communications - Not Reported - - Gould GG , et al. (2010)
Developmental profile - Not Reported - - Gould GG , et al. (2010)
Emotion - Not Reported - - Gould GG , et al. (2010)
Homeostasis - Not Reported - - Gould GG , et al. (2010)
Immune response - Not Reported - - Gould GG , et al. (2010)
Learning & memory - Not Reported - - Gould GG , et al. (2010)
Maternal behavior - Not Reported - - Gould GG , et al. (2010)
Molecular profile - Not Reported - - Gould GG , et al. (2010)
Motor phenotype - Not Reported - - Gould GG , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gould GG , et al. (2010)
Neurophysiology - Not Reported - - Gould GG , et al. (2010)
Repetitive behavior Repetitive digging Refractory Marble-burying test 3-4 months Gould GG , et al. (2010)
Seizure - Not Reported - - Gould GG , et al. (2010)
Sensory - Not Reported - - Gould GG , et al. (2010)
Social behavior Social approach Ameliorated Three-chamber social approach test 3-4 months Gould GG , et al. (2010)
Social behavior Social memory Side Effect Three-chamber social approach test: social novelty 3-4 months Gould GG , et al. (2010)

M_BTBR_1_Inbred_HM_CGS

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

10-week old adult male BTBR T+tf/J inbred mice were intraperitonealy injected with a single dose of 0.03mg/kg Adenosine A2A receptor agonist CGS 21680 for 7 days.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Ansari MA , et al. (2017)
Communications - Not Reported - - Ansari MA , et al. (2017)
Developmental profile - Not Reported - - Ansari MA , et al. (2017)
Emotion - Not Reported - - Ansari MA , et al. (2017)
Homeostasis - Not Reported - - Ansari MA , et al. (2017)
Immune response Adaptive immune response: T cells Restored Flow cytometric analysis 11 weeks Ansari MA , et al. (2017)
Immune response Adaptive immune response: T cells Ameliorated Flow cytometric analysis 11 weeks Ansari MA , et al. (2017)
Learning & memory - Not Reported - - Ansari MA , et al. (2017)
Maternal behavior - Not Reported - - Ansari MA , et al. (2017)
Molecular profile Gene expression Restored Quantitative PCR (qRT-PCR) 11 weeks Ansari MA , et al. (2017)
Molecular profile Gene expression Ameliorated Quantitative PCR (qRT-PCR) 11 weeks Ansari MA , et al. (2017)
Molecular profile Protein expression level evidence Restored Western blot 11 weeks Ansari MA , et al. (2017)
Molecular profile Protein expression level evidence Ameliorated Western blot 11 weeks Ansari MA , et al. (2017)
Molecular profile Protein phosphorylation Restored Western blot 11 weeks Ansari MA , et al. (2017)
Motor phenotype - Not Reported - - Ansari MA , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Ansari MA , et al. (2017)
Neurophysiology - Not Reported - - Ansari MA , et al. (2017)
Repetitive behavior Self grooming: perseveration Restored Grooming behavior assessments 11 weeks Ansari MA , et al. (2017)
Seizure - Not Reported - - Ansari MA , et al. (2017)
Sensory Pain or nociception Ameliorated Hot plate test 11 weeks Ansari MA , et al. (2017)
Social behavior - Not Reported - - Ansari MA , et al. (2017)

M_BTBR_1_inbred_HM_Clobazam

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were injected with 0.05 mg/kg clobazam (i.p.), a low dose of the drug

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion Anxiety No Adverse Effect Open field test 6-10 months Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory - Not Reported - - Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity No Adverse Effect Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior - Not Reported - - Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social approach Ameliorated Three-chamber social approach test 6-10 months Han S , et al. (2014)

M_BTBR_1_inbred_HM_Clonazepam-1

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with 0.05 mg/kg, of Clonazepam 30 min before testing in each trial. This dose was tested to be NON-sedative. Lower doses than 0.05 were also tested and found to be less effective than the optimal dose of 0.05 mg/kg and are not indicated separately here

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion Anxiety Restored Open field test 6-10 months Han S , et al. (2014)
Emotion Anxiety Ameliorated Elevated plus maze test 6-10 months Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context Ameliorated Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context: Short-term memory Ameliorated Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Learning & memory Spatial reference memory Restored Barnes maze test: probe trial 6-10 months Han S , et al. (2014)
Learning & memory Spatial working memory Restored Barnes maze test: learning during training sessions 6-10 months Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity Ameliorated Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior Circling Ameliorated Open field test 6-10 months Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social approach Ameliorated Three-chamber social approach test 6-10 months Han S , et al. (2014)
Social behavior Social approach No Sustained Effect Three-chamber social approach test 6-10 months Han S , et al. (2014)
Social behavior Social interaction Ameliorated Reciprocal social interaction test 6-10 months Han S , et al. (2014)
Social behavior Social interaction No Sustained Effect Reciprocal social interaction test 6-10 months Han S , et al. (2014)

M_BTBR_1_inbred_HM_Clonazepam-2

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with 0.075, or 0.1 mg/kg Clonazepam 30 min before testing in each trial (separate cohorts for doses). These were NON-sedative

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion - Not Reported - - Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context Refractory Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context: Short-term memory Refractory Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype - Not Reported - - Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior - Not Reported - - Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social interaction Refractory Three-chamber social approach test 6-10 months Han S , et al. (2014)

M_BTBR_1_inbred_HM_Clonazepam-4

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

-

Mutation:

BTBR mice are injected (i.p.) with Clonezapam at 1 mg/kg, every day for 14 days, 30 min before testing in trials. This dose was tested to have SEDATIVE effects on the mice

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion - Not Reported - - Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory - Not Reported - - Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity Side Effect Open field test 6-10 months Han S , et al. (2014)
Motor phenotype General locomotor activity Side Effect Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior - Not Reported - - Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior - Not Reported - - Han S , et al. (2014)

M_BTBR_1_inbred_HM_Clonazepam_3

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice are injected (i.p.) with Clonezapam at 0.05 mg/kg, every day for 14 days, 30 min before testing in trials. This dose and paradigm was NON-sedative to mice

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion - Not Reported - - Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context Ameliorated Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity Ameliorated Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior - Not Reported - - Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social interaction Ameliorated Reciprocal social interaction test 6-10 months Han S , et al. (2014)

M_BTBR_1_inbred_HM_colearning

Model Source:

JAX

Model Type:

RESCUE-Behavioral

Strain of Origin:

BTBR

Mutation:

BTBR mice raised under social enrichment conditions (2 BTBR and 2 C57BL/6J mice) were through co-learning process with cagemates during the training phase of behavior tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Restored Monitoring ultrasonic vocalizations: object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Side Effect Monitoring ultrasonic vocalizations: object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Refractory Monitoring ultrasonic vocalizations: fear conditioning test: acoustic cue-dependent 12-14 weeks Lipina TV and Roder JC (2012)
Communications Ultrasonic vocalization Side Effect Monitoring ultrasonic vocalizations: fear conditioning test: contextual 12-14 weeks Lipina TV and Roder JC (2012)
Developmental profile - Not Reported - - Lipina TV and Roder JC (2012)
Emotion - Not Reported - - Lipina TV and Roder JC (2012)
Homeostasis - Not Reported - - Lipina TV and Roder JC (2012)
Immune response - Not Reported - - Lipina TV and Roder JC (2012)
Learning & memory Cued or contextual fear conditioning Ameliorated Fear conditioning test: contextual 12-14 weeks Lipina TV and Roder JC (2012)
Learning & memory Cued or contextual fear conditioning Ameliorated Fear conditioning test: acoustic cue-dependent 12-14 weeks Lipina TV and Roder JC (2012)
Learning & memory Object recognition memory Restored Object-place recognition test 12-14 weeks Lipina TV and Roder JC (2012)
Maternal behavior - Not Reported - - Lipina TV and Roder JC (2012)
Molecular profile - Not Reported - - Lipina TV and Roder JC (2012)
Motor phenotype Hyperactivity Restored Elevated plus maze test 12-14 weeks Lipina TV and Roder JC (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Lipina TV and Roder JC (2012)
Neurophysiology - Not Reported - - Lipina TV and Roder JC (2012)
Repetitive behavior - Not Reported - - Lipina TV and Roder JC (2012)
Seizure - Not Reported - - Lipina TV and Roder JC (2012)
Sensory - Not Reported - - Lipina TV and Roder JC (2012)
Social behavior - Not Reported - - Lipina TV and Roder JC (2012)

M_BTBR_1_inbred_HM_CX1739

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were p.o. administrated with CX1739 (3, 10, or 30 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Refractory Grooming behavior assessments 7 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Social approach Ameliorated Three-chamber social approach test 6 weeks Silverman JL , et al. (2012)

M_BTBR_1_inbred_HM_CX1837

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were p.o. administrated with CX1837 (0.3, 1.0, or 3.0 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications Ultrasonic vocalization Refractory Monitoring ultrasonic vocalizations 6-8 weeks Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety Ameliorated Open field test 8 weeks Silverman JL , et al. (2012)
Emotion Anxiety Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory Object recognition memory Ameliorated Novel object recognition test 6-8 weeks Silverman JL , et al. (2012)
Learning & memory Object recognition memory Refractory Novel object recognition test 6-8 weeks Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Refractory Grooming behavior assessments 7 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Social approach Ameliorated Three-chamber social approach test 6 weeks Silverman JL , et al. (2012)
Social behavior Social interaction: opposite sex Refractory Reciprocal social interaction test 6-8 weeks Silverman JL , et al. (2012)

M_BTBR_1_inbred_HM_CX546

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were p.o. or i.p. administrated with CX546 (25, 50, 75, or 100 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Side Effect Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Ameliorated Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Refractory Open field test 8 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Refractory Grooming behavior assessments 7 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Social approach Ameliorated Three-chamber social approach test 6 weeks Silverman JL , et al. (2012)

M_BTBR_1_inbred_HM_CX929

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with CX929 (5 mg/kg) twice daily for four days

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Seese RR , et al. (2014)
Communications - Not Reported - - Seese RR , et al. (2014)
Developmental profile - Not Reported - - Seese RR , et al. (2014)
Emotion - Not Reported - - Seese RR , et al. (2014)
Homeostasis - Not Reported - - Seese RR , et al. (2014)
Immune response - Not Reported - - Seese RR , et al. (2014)
Learning & memory Object recognition memory Refractory Object-place recognition test 4-6 months Seese RR , et al. (2014)
Maternal behavior - Not Reported - - Seese RR , et al. (2014)
Molecular profile - Not Reported - - Seese RR , et al. (2014)
Motor phenotype - Not Reported - - Seese RR , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Seese RR , et al. (2014)
Neurophysiology - Not Reported - - Seese RR , et al. (2014)
Repetitive behavior - Not Reported - - Seese RR , et al. (2014)
Seizure - Not Reported - - Seese RR , et al. (2014)
Sensory - Not Reported - - Seese RR , et al. (2014)
Social behavior - Not Reported - - Seese RR , et al. (2014)

M_BTBR_1_inbred_HM_Cycloserine

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR male mice were i.p. injected with D-cycloserine (320 mg/kg in saline)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Burket JA , et al. (2013)
Communications - Not Reported - - Burket JA , et al. (2013)
Developmental profile - Not Reported - - Burket JA , et al. (2013)
Emotion - Not Reported - - Burket JA , et al. (2013)
Homeostasis - Not Reported - - Burket JA , et al. (2013)
Immune response - Not Reported - - Burket JA , et al. (2013)
Learning & memory - Not Reported - - Burket JA , et al. (2013)
Maternal behavior - Not Reported - - Burket JA , et al. (2013)
Molecular profile - Not Reported - - Burket JA , et al. (2013)
Motor phenotype General locomotor activity Restored Compartment transitions in three-chambered apparatus 4 weeks Burket JA , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Burket JA , et al. (2013)
Neurophysiology - Not Reported - - Burket JA , et al. (2013)
Repetitive behavior - Not Reported - - Burket JA , et al. (2013)
Seizure - Not Reported - - Burket JA , et al. (2013)
Sensory - Not Reported - - Burket JA , et al. (2013)
Social behavior Juvenile play Refractory Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Rearing behavior Refractory Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Self grooming: social context Side Effect Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social approach Restored Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social interaction Ameliorated Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social withdrawal Restored Three-chamber social approach test 4 weeks Burket JA , et al. (2013)

M_BTBR_1_inbred_HM_Diazepam-1

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with diazepam (2.0 mg/kg in saline with 2% Tween-80) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Pobbe RL , et al. (2010)
Communications - Not Reported - - Pobbe RL , et al. (2010)
Developmental profile - Not Reported - - Pobbe RL , et al. (2010)
Emotion - Not Reported - - Pobbe RL , et al. (2010)
Homeostasis - Not Reported - - Pobbe RL , et al. (2010)
Immune response - Not Reported - - Pobbe RL , et al. (2010)
Learning & memory - Not Reported - - Pobbe RL , et al. (2010)
Maternal behavior - Not Reported - - Pobbe RL , et al. (2010)
Molecular profile - Not Reported - - Pobbe RL , et al. (2010)
Motor phenotype - Not Reported - - Pobbe RL , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Pobbe RL , et al. (2010)
Neurophysiology - Not Reported - - Pobbe RL , et al. (2010)
Repetitive behavior - Not Reported - - Pobbe RL , et al. (2010)
Seizure - Not Reported - - Pobbe RL , et al. (2010)
Sensory - Not Reported - - Pobbe RL , et al. (2010)
Social behavior Social approach Restored Three-chamber social approach test 14-17 weeks Pobbe RL , et al. (2010)

M_BTBR_1_inbred_HM_Diazepam-2

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with diazepam (2 mg/kg) 20 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Defensor EB , et al. (2010)
Communications - Not Reported - - Defensor EB , et al. (2010)
Developmental profile - Not Reported - - Defensor EB , et al. (2010)
Emotion Anxiety Ameliorated Reciprocal social interaction test 12-14 weeks Defensor EB , et al. (2010)
Homeostasis - Not Reported - - Defensor EB , et al. (2010)
Immune response - Not Reported - - Defensor EB , et al. (2010)
Learning & memory - Not Reported - - Defensor EB , et al. (2010)
Maternal behavior - Not Reported - - Defensor EB , et al. (2010)
Molecular profile - Not Reported - - Defensor EB , et al. (2010)
Motor phenotype - Not Reported - - Defensor EB , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Defensor EB , et al. (2010)
Neurophysiology - Not Reported - - Defensor EB , et al. (2010)
Repetitive behavior - Not Reported - - Defensor EB , et al. (2010)
Seizure - Not Reported - - Defensor EB , et al. (2010)
Sensory - Not Reported - - Defensor EB , et al. (2010)
Social behavior Rearing behavior Side Effect Reciprocal social interaction test 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Refractory Reciprocal social interaction test: Nose tip-to-nose tip contact 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Refractory Reciprocal social interaction test: Nose-to-head contact 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Ameliorated Reciprocal social interaction test: no. of crawl overs 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social interaction Refractory Reciprocal social interaction test: Nose-to-anogenital contact 12-14 weeks Defensor EB , et al. (2010)
Social behavior Social withdrawal Ameliorated Reciprocal social interaction test 12-14 weeks Defensor EB , et al. (2010)

M_BTBR_1_inbred_HM_diazepam-3

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

Adult BTBR mice were treated with diazepam (20mg/kg in saline) or vehicle, daily, for 14 days (i.p.) between P45-P58

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gogolla N , et al. (2014)
Communications - Not Reported - - Gogolla N , et al. (2014)
Developmental profile - Not Reported - - Gogolla N , et al. (2014)
Emotion - Not Reported - - Gogolla N , et al. (2014)
Homeostasis - Not Reported - - Gogolla N , et al. (2014)
Immune response - Not Reported - - Gogolla N , et al. (2014)
Learning & memory - Not Reported - - Gogolla N , et al. (2014)
Maternal behavior - Not Reported - - Gogolla N , et al. (2014)
Molecular profile - Not Reported - - Gogolla N , et al. (2014)
Motor phenotype - Not Reported - - Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gogolla N , et al. (2014)
Neurophysiology - Not Reported - - Gogolla N , et al. (2014)
Repetitive behavior - Not Reported - - Gogolla N , et al. (2014)
Seizure - Not Reported - - Gogolla N , et al. (2014)
Sensory Multisensory integration: sensory neurons of insular cortex: auditory-tactile Refractory Application of tactile and auditory cues: pure tones (80dB) and air puffs adminitered to the contralateral fron paw; Quantification of degree of integration Adult Gogolla N , et al. (2014)
Sensory Sensory-evoked response: excitation: auditory stimulus Refractory Application of auditory stimuli: pure tone; Measurement of area of activation (ROI) in the insular cortex; Grooming behavior assessments: self grooming Adult Gogolla N , et al. (2014)
Social behavior - Not Reported - - Gogolla N , et al. (2014)

M_BTBR_1_inbred_HM_Diazepam-Adult

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

Adult BTBR mice were acutely injected with 20mg/kg (in saline) of diazepam (i.p.) while the animal was undergoing intrinsic imaging experiment

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gogolla N , et al. (2014)
Communications - Not Reported - - Gogolla N , et al. (2014)
Developmental profile - Not Reported - - Gogolla N , et al. (2014)
Emotion - Not Reported - - Gogolla N , et al. (2014)
Homeostasis - Not Reported - - Gogolla N , et al. (2014)
Immune response - Not Reported - - Gogolla N , et al. (2014)
Learning & memory - Not Reported - - Gogolla N , et al. (2014)
Maternal behavior - Not Reported - - Gogolla N , et al. (2014)
Molecular profile - Not Reported - - Gogolla N , et al. (2014)
Motor phenotype - Not Reported - - Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gogolla N , et al. (2014)
Neurophysiology - Not Reported - - Gogolla N , et al. (2014)
Repetitive behavior - Not Reported - - Gogolla N , et al. (2014)
Seizure - Not Reported - - Gogolla N , et al. (2014)
Sensory Multisensory integration: sensory neurons of insular cortex: auditory-tactile Ameliorated Application of tactile and auditory cues: pure tones (80dB) and air puffs adminitered to the contralateral fron paw; Quantification of degree of integration Adult Gogolla N , et al. (2014)
Social behavior - Not Reported - - Gogolla N , et al. (2014)

M_BTBR_1_inbred_HM_Diazepam-Juv

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

Juvenile BTBR mice were treated with diazepam (20mg/kg in saline) or vehicle (0.9% saline) , daily for 14 days (i.p.), between P15-P28

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gogolla N , et al. (2014)
Communications - Not Reported - - Gogolla N , et al. (2014)
Developmental profile - Not Reported - - Gogolla N , et al. (2014)
Emotion - Not Reported - - Gogolla N , et al. (2014)
Homeostasis - Not Reported - - Gogolla N , et al. (2014)
Immune response - Not Reported - - Gogolla N , et al. (2014)
Learning & memory - Not Reported - - Gogolla N , et al. (2014)
Maternal behavior - Not Reported - - Gogolla N , et al. (2014)
Molecular profile - Not Reported - - Gogolla N , et al. (2014)
Motor phenotype - Not Reported - - Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Perineuronal net morphology Ameliorated Immunohistochemistry: wisteria floribunda agglutinin (WFA) perineuronal nets 10-14 weeks Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: Inhibitory Ameliorated Immunohistochemistry: GAD65 10-14 weeks Gogolla N , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Ameliorated Immunohistochemistry: Parvalbumin and NeuN 10-14 weeks Gogolla N , et al. (2014)
Neurophysiology - Not Reported - - Gogolla N , et al. (2014)
Repetitive behavior - Not Reported - - Gogolla N , et al. (2014)
Seizure - Not Reported - - Gogolla N , et al. (2014)
Sensory Multisensory integration: sensory neurons of insular cortex: auditory-tactile Restored Application of tactile and auditory cues: pure tones (80dB) and air puffs adminitered to the contralateral fron paw; Quantification of degree of integration 10-14 weeks Gogolla N , et al. (2014)
Sensory Sensory-evoked response: excitation: auditory stimulus Restored Application of auditory stimuli: pure tone; Measurement of area of activation (ROI) in the insular cortex; Grooming behavior assessments: self grooming 10-14 weeks Gogolla N , et al. (2014)
Social behavior - Not Reported - - Gogolla N , et al. (2014)

M_BTBR_1_inbred_HM_Donepezil-DMS

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were injected intracranially into dorsomedial-striatum (DMS) by a cannula implantation with artificial cerebrospinal fluid (aCSF) in the third running day for acclimation and with Donepezil (100 ng/ 0.5 l aCSF) in each day from the fourth day until the end of experiment

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Karvat G and Kimchi T (2013)
Communications - Not Reported - - Karvat G and Kimchi T (2013)
Developmental profile - Not Reported - - Karvat G and Kimchi T (2013)
Emotion - Not Reported - - Karvat G and Kimchi T (2013)
Homeostasis - Not Reported - - Karvat G and Kimchi T (2013)
Immune response - Not Reported - - Karvat G and Kimchi T (2013)
Learning & memory Cognitive flexibility Restored Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Object recognition memory No Adverse Effect Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Procedural learning No Adverse Effect Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Maternal behavior - Not Reported - - Karvat G and Kimchi T (2013)
Molecular profile - Not Reported - - Karvat G and Kimchi T (2013)
Motor phenotype Self grooming: home cage/familiar environment No Adverse Effect Home cage behavior 8 weeks Karvat G and Kimchi T (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Karvat G and Kimchi T (2013)
Neurophysiology - Not Reported - - Karvat G and Kimchi T (2013)
Repetitive behavior Repetitive digging No Adverse Effect Home cage behavior 8 weeks Karvat G and Kimchi T (2013)
Seizure - Not Reported - - Karvat G and Kimchi T (2013)
Sensory - Not Reported - - Karvat G and Kimchi T (2013)
Social behavior Social interaction Ameliorated Running wheel test: jammed wheel: social interaction 8 weeks Karvat G and Kimchi T (2013)

M_BTBR_1_inbred_HM_Donepezil-VMS

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were injected intracranially into ventromedial-striatum (VMS) by a cannula implantation with artificial cerebrospinal fluid (aCSF) in the third running day for acclimation and with Donepezil (100 ng/ 0.5 l aCSF) in each day from the fourth day until the end of experiment

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Karvat G and Kimchi T (2013)
Communications - Not Reported - - Karvat G and Kimchi T (2013)
Developmental profile - Not Reported - - Karvat G and Kimchi T (2013)
Emotion - Not Reported - - Karvat G and Kimchi T (2013)
Homeostasis - Not Reported - - Karvat G and Kimchi T (2013)
Immune response - Not Reported - - Karvat G and Kimchi T (2013)
Learning & memory Cognitive flexibility Refractory Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Object recognition memory No Adverse Effect Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Procedural learning No Adverse Effect Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Maternal behavior - Not Reported - - Karvat G and Kimchi T (2013)
Molecular profile - Not Reported - - Karvat G and Kimchi T (2013)
Motor phenotype Self grooming: home cage/familiar environment No Adverse Effect Home cage behavior 8 weeks Karvat G and Kimchi T (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Karvat G and Kimchi T (2013)
Neurophysiology - Not Reported - - Karvat G and Kimchi T (2013)
Repetitive behavior Repetitive digging No Adverse Effect Home cage behavior 8 weeks Karvat G and Kimchi T (2013)
Seizure - Not Reported - - Karvat G and Kimchi T (2013)
Sensory - Not Reported - - Karvat G and Kimchi T (2013)
Social behavior Social interaction Refractory Running wheel test: jammed wheel: social interaction 8 weeks Karvat G and Kimchi T (2013)

M_BTBR_1_inbred_HM_Donepezil_ip

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR male mice are injected i.p. with Donepezil (0.3 and 1.0 mg/kg) for 7 days

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Karvat G and Kimchi T (2013)
Communications - Not Reported - - Karvat G and Kimchi T (2013)
Developmental profile - Not Reported - - Karvat G and Kimchi T (2013)
Emotion Anxiety No Adverse Effect Open field test 8 weeks Karvat G and Kimchi T (2013)
Homeostasis - Not Reported - - Karvat G and Kimchi T (2013)
Immune response - Not Reported - - Karvat G and Kimchi T (2013)
Learning & memory Cognitive flexibility Ameliorated Water T-maze test: reversal learning 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Cognitive flexibility Restored Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Object recognition memory No Adverse Effect Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Procedural learning No Adverse Effect Running wheel test: jammed wheel 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Spatial learning No Adverse Effect Water T-maze test: reversal learning 8 weeks Karvat G and Kimchi T (2013)
Learning & memory Spatial working memory No Adverse Effect Water T-maze test: reversal learning 8 weeks Karvat G and Kimchi T (2013)
Maternal behavior - Not Reported - - Karvat G and Kimchi T (2013)
Molecular profile - Not Reported - - Karvat G and Kimchi T (2013)
Motor phenotype General locomotor activity No Adverse Effect Open field test 8 weeks Karvat G and Kimchi T (2013)
Motor phenotype Self grooming: home cage/familiar environment No Adverse Effect Home cage behavior 8 weeks Karvat G and Kimchi T (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Karvat G and Kimchi T (2013)
Neurophysiology - Not Reported - - Karvat G and Kimchi T (2013)
Repetitive behavior Repetitive digging No Adverse Effect Home cage behavior 8 weeks Karvat G and Kimchi T (2013)
Seizure - Not Reported - - Karvat G and Kimchi T (2013)
Sensory - Not Reported - - Karvat G and Kimchi T (2013)
Social behavior Social approach Ameliorated Three-chamber social approach test 8 weeks Karvat G and Kimchi T (2013)
Social behavior Social interaction Ameliorated Reciprocal social interaction test 8 weeks Karvat G and Kimchi T (2013)
Social behavior Social interaction Ameliorated Running wheel test: jammed wheel: social interaction 8 weeks Karvat G and Kimchi T (2013)
Social behavior Social memory Ameliorated Three-chamber social approach test 8 weeks Karvat G and Kimchi T (2013)

M_BTBR_1_inbred_HM_Fluoxetine-1-H

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with fluoxetine (30 mg/kg) 1 h before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Chadman KK (2010)
Communications - Not Reported - - Chadman KK (2010)
Developmental profile - Not Reported - - Chadman KK (2010)
Emotion Anxiety No Adverse Effect Elevated plus maze test 8-15 weeks Chadman KK (2010)
Homeostasis - Not Reported - - Chadman KK (2010)
Immune response - Not Reported - - Chadman KK (2010)
Learning & memory - Not Reported - - Chadman KK (2010)
Maternal behavior - Not Reported - - Chadman KK (2010)
Molecular profile - Not Reported - - Chadman KK (2010)
Motor phenotype General locomotor activity Side Effect Compartment transitions in three-chambered apparatus 8-15 weeks Chadman KK (2010)
Motor phenotype Hypoactivity Side Effect Elevated plus maze test 8-15 weeks Chadman KK (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Chadman KK (2010)
Neurophysiology - Not Reported - - Chadman KK (2010)
Repetitive behavior - Not Reported - - Chadman KK (2010)
Seizure - Not Reported - - Chadman KK (2010)
Sensory - Not Reported - - Chadman KK (2010)
Social behavior Social approach Ameliorated Three-chamber social approach test 8-15 weeks Chadman KK (2010)
Social behavior Social memory Side Effect Three-chamber social approach test: social novelty 8-15 weeks Chadman KK (2010)

M_BTBR_1_inbred_HM_Fluoxetine-1-L

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with fluoxetine (10 mg/kg) 1 h before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Chadman KK (2010)
Communications - Not Reported - - Chadman KK (2010)
Developmental profile - Not Reported - - Chadman KK (2010)
Emotion Anxiety No Adverse Effect Elevated plus maze test 8-15 weeks Chadman KK (2010)
Homeostasis - Not Reported - - Chadman KK (2010)
Immune response - Not Reported - - Chadman KK (2010)
Learning & memory - Not Reported - - Chadman KK (2010)
Maternal behavior - Not Reported - - Chadman KK (2010)
Molecular profile - Not Reported - - Chadman KK (2010)
Motor phenotype General locomotor activity No Adverse Effect Compartment transitions in three-chambered apparatus 8-15 weeks Chadman KK (2010)
Motor phenotype Hypoactivity No Adverse Effect Elevated plus maze test 8-15 weeks Chadman KK (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Chadman KK (2010)
Neurophysiology - Not Reported - - Chadman KK (2010)
Repetitive behavior - Not Reported - - Chadman KK (2010)
Seizure - Not Reported - - Chadman KK (2010)
Sensory - Not Reported - - Chadman KK (2010)
Social behavior Social approach Restored Three-chamber social approach test 8-15 weeks Chadman KK (2010)
Social behavior Social memory No Adverse Effect Three-chamber social approach test: social novelty 8-15 weeks Chadman KK (2010)

M_BTBR_1_inbred_HM_fluoxetine_2

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with fluoxetine (10 mg/kg) before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gould GG , et al. (2010)
Communications - Not Reported - - Gould GG , et al. (2010)
Developmental profile - Not Reported - - Gould GG , et al. (2010)
Emotion - Not Reported - - Gould GG , et al. (2010)
Homeostasis - Not Reported - - Gould GG , et al. (2010)
Immune response - Not Reported - - Gould GG , et al. (2010)
Learning & memory - Not Reported - - Gould GG , et al. (2010)
Maternal behavior - Not Reported - - Gould GG , et al. (2010)
Molecular profile - Not Reported - - Gould GG , et al. (2010)
Motor phenotype - Not Reported - - Gould GG , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gould GG , et al. (2010)
Neurophysiology - Not Reported - - Gould GG , et al. (2010)
Repetitive behavior Repetitive digging Refractory Marble-burying test 3-4 months Gould GG , et al. (2010)
Seizure - Not Reported - - Gould GG , et al. (2010)
Sensory - Not Reported - - Gould GG , et al. (2010)
Social behavior Social approach Ameliorated Three-chamber social approach test 3-4 months Gould GG , et al. (2010)
Social behavior Social memory Side Effect Three-chamber social approach test: social novelty 3-4 months Gould GG , et al. (2010)

M_BTBR_1_inbred_HM_Fostering_B

Model Source:

JAX

Model Type:

RESCUE-Behavioral

Strain of Origin:

BTBR

Mutation:

BTBR mice were cross-fostered by BTBR mothers within 24-h of parturition

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Yang M , et al. (2007)
Communications - Not Reported - - Yang M , et al. (2007)
Developmental profile - Not Reported - - Yang M , et al. (2007)
Emotion - Not Reported - - Yang M , et al. (2007)
Homeostasis - Not Reported - - Yang M , et al. (2007)
Immune response - Not Reported - - Yang M , et al. (2007)
Learning & memory - Not Reported - - Yang M , et al. (2007)
Maternal behavior - Not Reported - - Yang M , et al. (2007)
Molecular profile - Not Reported - - Yang M , et al. (2007)
Motor phenotype Self grooming: home cage/familiar environment Refractory Home cage behavior Adult Yang M , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Yang M , et al. (2007)
Neurophysiology - Not Reported - - Yang M , et al. (2007)
Repetitive behavior - Not Reported - - Yang M , et al. (2007)
Seizure - Not Reported - - Yang M , et al. (2007)
Sensory - Not Reported - - Yang M , et al. (2007)
Social behavior Juvenile play Ameliorated Reciprocal social interaction test: juvenile play 3 weeks Yang M , et al. (2007)
Social behavior Juvenile play Refractory Reciprocal social interaction test: juvenile play 3 weeks Yang M , et al. (2007)
Social behavior Social approach Refractory Three-chamber social approach test Adult Yang M , et al. (2007)

M_BTBR_1_inbred_HM_Fostering_C

Model Source:

JAX

Model Type:

RESCUE-Behavioral

Strain of Origin:

BTBR

Mutation:

BTBR mice were cross-fostered by C57BL/6J mothers within 24-h of parturition

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Yang M , et al. (2007)
Communications - Not Reported - - Yang M , et al. (2007)
Developmental profile - Not Reported - - Yang M , et al. (2007)
Emotion - Not Reported - - Yang M , et al. (2007)
Homeostasis - Not Reported - - Yang M , et al. (2007)
Immune response - Not Reported - - Yang M , et al. (2007)
Learning & memory - Not Reported - - Yang M , et al. (2007)
Maternal behavior - Not Reported - - Yang M , et al. (2007)
Molecular profile - Not Reported - - Yang M , et al. (2007)
Motor phenotype Self grooming: home cage/familiar environment Refractory Home cage behavior Adult Yang M , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Yang M , et al. (2007)
Neurophysiology - Not Reported - - Yang M , et al. (2007)
Repetitive behavior - Not Reported - - Yang M , et al. (2007)
Seizure - Not Reported - - Yang M , et al. (2007)
Sensory - Not Reported - - Yang M , et al. (2007)
Social behavior Juvenile play Ameliorated Reciprocal social interaction test: juvenile play 3 weeks Yang M , et al. (2007)
Social behavior Juvenile play Refractory Reciprocal social interaction test: juvenile play 3 weeks Yang M , et al. (2007)
Social behavior Social approach Refractory Three-chamber social approach test Adult Yang M , et al. (2007)

M_BTBR_1_inbred_HM_GRN529

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with a single dose of GRN-529 ( 1.0, or 3.0 mg/kg in 10% Tween 80/saline)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion Anxiety No Adverse Effect Open field test 9-10 weeks Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype General locomotor activity Side Effect Open field test 9-10 weeks Silverman JL , et al. (2012)
Motor phenotype General locomotor activity No Adverse Effect Open field test 9-10 weeks Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Ameliorated Home cage behavior 9-10 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior Repetitive digging Ameliorated Three-chamber social approach test 8-16 weeks Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior Self grooming: social context Ameliorated Three-chamber social approach test 8-16 weeks Silverman JL , et al. (2012)
Social behavior Social approach Ameliorated Three-chamber social approach test 9-10 weeks Silverman JL , et al. (2012)
Social behavior Social interaction Ameliorated Three-chamber social approach test 8-16 weeks Silverman JL , et al. (2012)

M_BTBR_1_inbred_HM_keto

Model Source:

JAX

Model Type:

RESCUE-Dietary

Strain of Origin:

BTBR

Mutation:

BTBR male mice are fed with ketogenic diet for 3-5 weeks

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Ruskin DN , et al. (2013)
Communications - Not Reported - - Ruskin DN , et al. (2013)
Developmental profile - Not Reported - - Ruskin DN , et al. (2013)
Emotion - Not Reported - - Ruskin DN , et al. (2013)
Homeostasis - Not Reported - - Ruskin DN , et al. (2013)
Immune response - Not Reported - - Ruskin DN , et al. (2013)
Learning & memory - Not Reported - - Ruskin DN , et al. (2013)
Maternal behavior - Not Reported - - Ruskin DN , et al. (2013)
Molecular profile - Not Reported - - Ruskin DN , et al. (2013)
Motor phenotype Self grooming: home cage/familiar environment No Adverse Effect Home cage behavior 8-10 weeks Ruskin DN , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Ruskin DN , et al. (2013)
Neurophysiology - Not Reported - - Ruskin DN , et al. (2013)
Repetitive behavior - Not Reported - - Ruskin DN , et al. (2013)
Seizure Seizure threshold Refractory Observation of electrically induced seizures 8-10 weeks Ruskin DN , et al. (2013)
Sensory - Not Reported - - Ruskin DN , et al. (2013)
Social behavior Self grooming: social context Ameliorated Three-chamber social approach test: self grooming 8-10 weeks Ruskin DN , et al. (2013)
Social behavior Social approach Ameliorated Three-chamber social approach test 8-10 weeks Ruskin DN , et al. (2013)
Social behavior Social interaction Ameliorated Three-chamber social approach test: sociability 8-10 weeks Ruskin DN , et al. (2013)
Social behavior Social memory Refractory Three-chamber social approach test 8-10 weeks Ruskin DN , et al. (2013)
Social behavior Social transmission of food preference Ameliorated Social transmission of food preference 8-10 weeks Ruskin DN , et al. (2013)

M_BTBR_1_inbred_HM_L838417-1

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with 0.025, 0.05 mg/kg of L838,417. 0.05 mg/kg was found to be the effective dose and the other lower doses are not indicated separately here

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion - Not Reported - - Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context Ameliorated Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Learning & memory Cued or contextual fear conditioning: Memory of context: Short-term memory Ameliorated Fear conditioning test: contextual 6-10 months Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity No Adverse Effect Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior - Not Reported - - Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social approach Ameliorated Three-chamber social approach test 6-10 months Han S , et al. (2014)

M_BTBR_1_inbred_HM_L838417-2

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with 0.5 mg/kg L838,417

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Han S , et al. (2014)
Communications - Not Reported - - Han S , et al. (2014)
Developmental profile - Not Reported - - Han S , et al. (2014)
Emotion - Not Reported - - Han S , et al. (2014)
Homeostasis - Not Reported - - Han S , et al. (2014)
Immune response - Not Reported - - Han S , et al. (2014)
Learning & memory - Not Reported - - Han S , et al. (2014)
Maternal behavior - Not Reported - - Han S , et al. (2014)
Molecular profile - Not Reported - - Han S , et al. (2014)
Motor phenotype General locomotor activity Side Effect Open field test 6-10 months Han S , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Han S , et al. (2014)
Neurophysiology - Not Reported - - Han S , et al. (2014)
Repetitive behavior - Not Reported - - Han S , et al. (2014)
Seizure - Not Reported - - Han S , et al. (2014)
Sensory - Not Reported - - Han S , et al. (2014)
Social behavior Social approach Refractory Three-chamber social approach test 6-10 months Han S , et al. (2014)

M_BTBR_1_Inbred_HM_LCPUFA

Model Source:

JAX

Model Type:

RESCUE-Dietary

Strain of Origin:

BTBR

Mutation:

BTBR mice is treated with LCPUFA dietary, that contains low-glycemic index carbohydrates, dietary fibers, high trypthophan content and a lipid profile that predominantly differed in DHA and EPA content (omega-3 long-chain polyunsaturated fatty acids, for 7 consecutive weeks before testing

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Wu J , et al. (2016)
Communications - Not Reported - - Wu J , et al. (2016)
Developmental profile - Not Reported - - Wu J , et al. (2016)
Emotion - Not Reported - - Wu J , et al. (2016)
Homeostasis - Not Reported - - Wu J , et al. (2016)
Immune response - Not Reported - - Wu J , et al. (2016)
Learning & memory - Not Reported - - Wu J , et al. (2016)
Maternal behavior - Not Reported - - Wu J , et al. (2016)
Molecular profile Protein phosphorylation No Adverse Effect Western blot 12 weeks Wu J , et al. (2016)
Molecular profile Signaling: mTOR No Adverse Effect Western blot 12 weeks Wu J , et al. (2016)
Molecular profile Signaling: mTOR Refractory Western blot 12 weeks Wu J , et al. (2016)
Motor phenotype General locomotor activity Refractory Open field test 12 weeks Wu J , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Wu J , et al. (2016)
Neurophysiology - Not Reported - - Wu J , et al. (2016)
Repetitive behavior Self grooming: perseveration Refractory Grooming behavior assessments 12 weeks Wu J , et al. (2016)
Seizure - Not Reported - - Wu J , et al. (2016)
Sensory - Not Reported - - Wu J , et al. (2016)
Social behavior Social interaction Refractory Partition test 12 weeks Wu J , et al. (2016)

M_BTBR_1_inbred_HM_M100907_1_H

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with M100907 (0.1 mg/kg) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Amodeo DA , et al. (2014)
Communications - Not Reported - - Amodeo DA , et al. (2014)
Developmental profile - Not Reported - - Amodeo DA , et al. (2014)
Emotion - Not Reported - - Amodeo DA , et al. (2014)
Homeostasis - Not Reported - - Amodeo DA , et al. (2014)
Immune response - Not Reported - - Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Restored Spatial discrimination assay: reversal learning: time taken to learn and regressive errors 8 weeks Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Restored Spatial discrimination assay: reversal learning: regressive errors 8 weeks Amodeo DA , et al. (2014)
Learning & memory Spatial learning No Adverse Effect Spatial discrimination assay: acquisition 8 weeks Amodeo DA , et al. (2014)
Maternal behavior - Not Reported - - Amodeo DA , et al. (2014)
Molecular profile - Not Reported - - Amodeo DA , et al. (2014)
Motor phenotype - Not Reported - - Amodeo DA , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amodeo DA , et al. (2014)
Neurophysiology - Not Reported - - Amodeo DA , et al. (2014)
Repetitive behavior Perseveration No Adverse Effect Spatial discrimination assay: reversal learning: errors 8 weeks Amodeo DA , et al. (2014)
Seizure - Not Reported - - Amodeo DA , et al. (2014)
Sensory - Not Reported - - Amodeo DA , et al. (2014)
Social behavior - Not Reported - - Amodeo DA , et al. (2014)

M_BTBR_1_inbred_HM_M100907_1_L

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with M100907 (0.01 mg/kg) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Amodeo DA , et al. (2014)
Communications - Not Reported - - Amodeo DA , et al. (2014)
Developmental profile - Not Reported - - Amodeo DA , et al. (2014)
Emotion - Not Reported - - Amodeo DA , et al. (2014)
Homeostasis - Not Reported - - Amodeo DA , et al. (2014)
Immune response - Not Reported - - Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Restored Spatial discrimination assay: reversal learning 8 weeks Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Refractory Spatial discrimination assay: reversal learning: regressive errors 8 weeks Amodeo DA , et al. (2014)
Learning & memory Spatial learning No Adverse Effect Spatial discrimination assay: acquisition 8 weeks Amodeo DA , et al. (2014)
Maternal behavior - Not Reported - - Amodeo DA , et al. (2014)
Molecular profile - Not Reported - - Amodeo DA , et al. (2014)
Motor phenotype - Not Reported - - Amodeo DA , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amodeo DA , et al. (2014)
Neurophysiology - Not Reported - - Amodeo DA , et al. (2014)
Repetitive behavior Perseveration No Adverse Effect Spatial discrimination assay: reversal learning: errors 8 weeks Amodeo DA , et al. (2014)
Seizure - Not Reported - - Amodeo DA , et al. (2014)
Sensory - Not Reported - - Amodeo DA , et al. (2014)
Social behavior - Not Reported - - Amodeo DA , et al. (2014)

M_BTBR_1_inbred_HM_MDMA

Model Source:

Not Specified

Model Type:

Pharmaceutical intervention

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MDMA (20 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Onaivi ES , et al. (2011)
Communications - Not Reported - - Onaivi ES , et al. (2011)
Developmental profile - Not Reported - - Onaivi ES , et al. (2011)
Emotion - Not Reported - - Onaivi ES , et al. (2011)
Homeostasis - Not Reported - - Onaivi ES , et al. (2011)
Immune response - Not Reported - - Onaivi ES , et al. (2011)
Learning & memory - Not Reported - - Onaivi ES , et al. (2011)
Maternal behavior - Not Reported - - Onaivi ES , et al. (2011)
Molecular profile - Not Reported - - Onaivi ES , et al. (2011)
Motor phenotype General locomotor activity No Change Running wheel test Adult Onaivi ES , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: catecholamines No Change High-performance liquid chromatography (HPLC): striatum and frontal cortex Adult Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: serotonin No Change High-performance liquid chromatography (HPLC): striatum Adult Onaivi ES , et al. (2011)
Repetitive behavior - Not Reported - - Onaivi ES , et al. (2011)
Seizure - Not Reported - - Onaivi ES , et al. (2011)
Sensory - Not Reported - - Onaivi ES , et al. (2011)
Social behavior - Not Reported - - Onaivi ES , et al. (2011)

M_BTBR_1_inbred_HM_Meth

Model Source:

Not Specified

Model Type:

Pharmaceutical intervention

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with methamphetamine (10 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Onaivi ES , et al. (2011)
Communications - Not Reported - - Onaivi ES , et al. (2011)
Developmental profile - Not Reported - - Onaivi ES , et al. (2011)
Emotion - Not Reported - - Onaivi ES , et al. (2011)
Homeostasis - Not Reported - - Onaivi ES , et al. (2011)
Immune response - Not Reported - - Onaivi ES , et al. (2011)
Learning & memory - Not Reported - - Onaivi ES , et al. (2011)
Maternal behavior - Not Reported - - Onaivi ES , et al. (2011)
Molecular profile - Not Reported - - Onaivi ES , et al. (2011)
Motor phenotype General locomotor activity No Change Running wheel test Adult Onaivi ES , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: catecholamines Decreased High-performance liquid chromatography (HPLC): striatum Adult Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: catecholamines No Change High-performance liquid chromatography (HPLC): frontal cortex Adult Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: serotonin No Change High-performance liquid chromatography (HPLC): striatum Adult Onaivi ES , et al. (2011)
Repetitive behavior - Not Reported - - Onaivi ES , et al. (2011)
Seizure - Not Reported - - Onaivi ES , et al. (2011)
Sensory - Not Reported - - Onaivi ES , et al. (2011)
Social behavior - Not Reported - - Onaivi ES , et al. (2011)

M_BTBR_1_inbred_HM_MPEP_1

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPEP (5 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Seese RR , et al. (2014)
Communications - Not Reported - - Seese RR , et al. (2014)
Developmental profile - Not Reported - - Seese RR , et al. (2014)
Emotion - Not Reported - - Seese RR , et al. (2014)
Homeostasis - Not Reported - - Seese RR , et al. (2014)
Immune response - Not Reported - - Seese RR , et al. (2014)
Learning & memory Object recognition memory Restored Object-place recognition test 4-6 months Seese RR , et al. (2014)
Maternal behavior - Not Reported - - Seese RR , et al. (2014)
Molecular profile Signaling Ameliorated Fluorescence tomography 4-6 months Seese RR , et al. (2014)
Motor phenotype - Not Reported - - Seese RR , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Seese RR , et al. (2014)
Neurophysiology - Not Reported - - Seese RR , et al. (2014)
Repetitive behavior - Not Reported - - Seese RR , et al. (2014)
Seizure - Not Reported - - Seese RR , et al. (2014)
Sensory - Not Reported - - Seese RR , et al. (2014)
Social behavior - Not Reported - - Seese RR , et al. (2014)

M_BTBR_1_inbred_HM_MPEP_2

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPEP (10 mg/kg in saline)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion - Not Reported - - Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Ameliorated Home cage behavior 9-10 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior - Not Reported - - Silverman JL , et al. (2012)

M_BTBR_1_inbred_HM_MPEP_3

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPEP (0.50 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Refractory Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior - Not Reported - - Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_MPEP_4

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPEP (1.0 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Restored Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Refractory Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_MPEP_5

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPEP (10 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Refractory Open field test 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Restored Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Refractory Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_MPEP_6

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPEP (30 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Side Effect Open field test 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Restored Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Refractory Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_MPTP

Model Source:

Not Specified

Model Type:

Pharmaceutical intervention

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MPTP (20 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Onaivi ES , et al. (2011)
Communications - Not Reported - - Onaivi ES , et al. (2011)
Developmental profile - Not Reported - - Onaivi ES , et al. (2011)
Emotion - Not Reported - - Onaivi ES , et al. (2011)
Homeostasis - Not Reported - - Onaivi ES , et al. (2011)
Immune response - Not Reported - - Onaivi ES , et al. (2011)
Learning & memory - Not Reported - - Onaivi ES , et al. (2011)
Maternal behavior - Not Reported - - Onaivi ES , et al. (2011)
Molecular profile - Not Reported - - Onaivi ES , et al. (2011)
Motor phenotype General locomotor activity Increased Running wheel test Adult Onaivi ES , et al. (2011)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: catecholamines No Change High-performance liquid chromatography (HPLC): striatum and frontal cortex Adult Onaivi ES , et al. (2011)
Neurophysiology Neurotransmitter release: serotonin No Change High-performance liquid chromatography (HPLC): striatum Adult Onaivi ES , et al. (2011)
Repetitive behavior - Not Reported - - Onaivi ES , et al. (2011)
Seizure - Not Reported - - Onaivi ES , et al. (2011)
Sensory - Not Reported - - Onaivi ES , et al. (2011)
Social behavior - Not Reported - - Onaivi ES , et al. (2011)

M_BTBR_1_inbred_HM_MTEP

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with MTEP (0.3, 0.6, 1.0 or 3.0 mg/kg in saline)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2012)
Communications - Not Reported - - Silverman JL , et al. (2012)
Developmental profile - Not Reported - - Silverman JL , et al. (2012)
Emotion - Not Reported - - Silverman JL , et al. (2012)
Homeostasis - Not Reported - - Silverman JL , et al. (2012)
Immune response - Not Reported - - Silverman JL , et al. (2012)
Learning & memory - Not Reported - - Silverman JL , et al. (2012)
Maternal behavior - Not Reported - - Silverman JL , et al. (2012)
Molecular profile - Not Reported - - Silverman JL , et al. (2012)
Motor phenotype Self grooming: home cage/familiar environment Restored Home cage behavior 9-10 weeks Silverman JL , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2012)
Neurophysiology - Not Reported - - Silverman JL , et al. (2012)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2012)
Seizure - Not Reported - - Silverman JL , et al. (2012)
Sensory - Not Reported - - Silverman JL , et al. (2012)
Social behavior - Not Reported - - Silverman JL , et al. (2012)

M_BTBR_1_Inbred_HM_mTOR-diet

Model Source:

JAX

Model Type:

RESCUE-Dietary

Strain of Origin:

BTBR

Mutation:

BTBR mice is treated with the mTOR-targeting amino acid dietary, that aimed to attenuate the mTOR signaling pathway, for 7 consecutive weeks before testing

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Wu J , et al. (2016)
Communications - Not Reported - - Wu J , et al. (2016)
Developmental profile - Not Reported - - Wu J , et al. (2016)
Emotion - Not Reported - - Wu J , et al. (2016)
Homeostasis - Not Reported - - Wu J , et al. (2016)
Immune response - Not Reported - - Wu J , et al. (2016)
Learning & memory - Not Reported - - Wu J , et al. (2016)
Maternal behavior - Not Reported - - Wu J , et al. (2016)
Molecular profile Protein phosphorylation No Adverse Effect Western blot 12 weeks Wu J , et al. (2016)
Molecular profile Signaling: mTOR No Adverse Effect Western blot 12 weeks Wu J , et al. (2016)
Molecular profile Signaling: mTOR Restored Western blot 12 weeks Wu J , et al. (2016)
Motor phenotype General locomotor activity Refractory Open field test 12 weeks Wu J , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Wu J , et al. (2016)
Neurophysiology - Not Reported - - Wu J , et al. (2016)
Repetitive behavior Self grooming: perseveration Restored Grooming behavior assessments 12 weeks Wu J , et al. (2016)
Seizure - Not Reported - - Wu J , et al. (2016)
Sensory - Not Reported - - Wu J , et al. (2016)
Social behavior Social interaction Refractory Partition test 12 weeks Wu J , et al. (2016)

M_BTBR_1_inbred_HM_peer-interact

Model Source:

JAX

Model Type:

RESCUE-Behavioral

Strain of Origin:

BTBR

Mutation:

Weaned BTBR mice lived with C57BL/6J cagemates 40 or 60 days before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Yang M , et al. (2010)
Communications - Not Reported - - Yang M , et al. (2010)
Developmental profile - Not Reported - - Yang M , et al. (2010)
Emotion - Not Reported - - Yang M , et al. (2010)
Homeostasis - Not Reported - - Yang M , et al. (2010)
Immune response - Not Reported - - Yang M , et al. (2010)
Learning & memory - Not Reported - - Yang M , et al. (2010)
Maternal behavior - Not Reported - - Yang M , et al. (2010)
Molecular profile - Not Reported - - Yang M , et al. (2010)
Motor phenotype General locomotor activity No Adverse Effect Three-chamber social approach test: compartment transitions 6-8 weeks Yang M , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Yang M , et al. (2010)
Neurophysiology - Not Reported - - Yang M , et al. (2010)
Repetitive behavior Self grooming: perseveration Refractory Grooming behavior assessments 6-8 weeks Yang M , et al. (2010)
Seizure - Not Reported - - Yang M , et al. (2010)
Sensory - Not Reported - - Yang M , et al. (2010)
Social behavior Social approach Ameliorated Three-chamber social approach test 6-8 weeks Yang M , et al. (2010)

M_BTBR_1_inbred_HM_PSD95-GFP

Model Source:

JAX

Model Type:

Genetic

Strain of Origin:

BTBR

Mutation:

The progenitor cells for layer 2/3 neurons in the somatosensory cortex and anterior frontal cortex of BTBR were transfected using in utero electroporation. E15.5 timed pregnant mice were deeply anaesthetized, their uterine horns were exposed and approximately 1ul of DNA mixture, containing DsRed2 plasmid (1ug/ul) and PSD-95-GFP plasmid (1-2ug/ul), was pressure injected into the lateral ventricle of each embryo through a micropipette. Electric pulses were passed through the head of each embryo using two tweezer type electrodes for electroporation.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Isshiki M , et al. (2014)
Communications - Not Reported - - Isshiki M , et al. (2014)
Developmental profile - Not Reported - - Isshiki M , et al. (2014)
Emotion - Not Reported - - Isshiki M , et al. (2014)
Homeostasis - Not Reported - - Isshiki M , et al. (2014)
Immune response - Not Reported - - Isshiki M , et al. (2014)
Learning & memory - Not Reported - - Isshiki M , et al. (2014)
Maternal behavior - Not Reported - - Isshiki M , et al. (2014)
Molecular profile - Not Reported - - Isshiki M , et al. (2014)
Motor phenotype - Not Reported - - Isshiki M , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine turnover Increased Two-photon microscopy: in vivo over two days, anterior frontal cortex 3 weeks Isshiki M , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine turnover No Change Two-photon microscopy: in vivo over two days, anterior frontal cortex 3 weeks Isshiki M , et al. (2014)
Neurophysiology - Not Reported - - Isshiki M , et al. (2014)
Repetitive behavior - Not Reported - - Isshiki M , et al. (2014)
Seizure - Not Reported - - Isshiki M , et al. (2014)
Sensory - Not Reported - - Isshiki M , et al. (2014)
Social behavior - Not Reported - - Isshiki M , et al. (2014)

M_BTBR_1_inbred_HM_rapamycin

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with rapamycin (10 mg/kg) in a volume of 0.01 ml/g on four consecutive days

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Burket JA , et al. (2013)
Communications - Not Reported - - Burket JA , et al. (2013)
Developmental profile - Not Reported - - Burket JA , et al. (2013)
Emotion - Not Reported - - Burket JA , et al. (2013)
Homeostasis - Not Reported - - Burket JA , et al. (2013)
Immune response - Not Reported - - Burket JA , et al. (2013)
Learning & memory - Not Reported - - Burket JA , et al. (2013)
Maternal behavior - Not Reported - - Burket JA , et al. (2013)
Molecular profile - Not Reported - - Burket JA , et al. (2013)
Motor phenotype General locomotor activity Refractory Compartment transitions in three-chambered apparatus 4 weeks Burket JA , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Burket JA , et al. (2013)
Neurophysiology - Not Reported - - Burket JA , et al. (2013)
Repetitive behavior - Not Reported - - Burket JA , et al. (2013)
Seizure - Not Reported - - Burket JA , et al. (2013)
Sensory - Not Reported - - Burket JA , et al. (2013)
Social behavior Juvenile play No Adverse Effect Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Rearing behavior Refractory Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Self grooming: social context No Adverse Effect Three-chamber social approach test: self grooming during the test 4 weeks Burket JA , et al. (2013)
Social behavior Social approach Ameliorated Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social interaction Ameliorated Three-chamber social approach test 4 weeks Burket JA , et al. (2013)
Social behavior Social withdrawal No Adverse Effect Three-chamber social approach test 4 weeks Burket JA , et al. (2013)

M_BTBR_1_inbred_HM_Risperidone-1-H

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with risperidone (0.5 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Side Effect Open field test 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Side Effect Compartment transitions in three-chambered apparatus 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Refractory Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_Risperidone-1-L

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with risperidone (0.125 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Restored Open field test 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype General locomotor activity No Adverse Effect Compartment transitions in three-chambered apparatus 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Ameliorated Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Refractory Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_Risperidone-1-M

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with risperidone (0.25 mg/kg in saline) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Silverman JL , et al. (2009)
Communications - Not Reported - - Silverman JL , et al. (2009)
Developmental profile - Not Reported - - Silverman JL , et al. (2009)
Emotion - Not Reported - - Silverman JL , et al. (2009)
Homeostasis - Not Reported - - Silverman JL , et al. (2009)
Immune response - Not Reported - - Silverman JL , et al. (2009)
Learning & memory - Not Reported - - Silverman JL , et al. (2009)
Maternal behavior - Not Reported - - Silverman JL , et al. (2009)
Molecular profile - Not Reported - - Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Side Effect Open field test 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype General locomotor activity Side Effect Compartment transitions in three-chambered apparatus 6-8 weeks Silverman JL , et al. (2009)
Motor phenotype Self grooming: home cage/familiar environment Ameliorated Grooming behavior assessments 6-8 weeks Silverman JL , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Silverman JL , et al. (2009)
Neurophysiology - Not Reported - - Silverman JL , et al. (2009)
Repetitive behavior - Not Reported - - Silverman JL , et al. (2009)
Seizure - Not Reported - - Silverman JL , et al. (2009)
Sensory - Not Reported - - Silverman JL , et al. (2009)
Social behavior Social approach Refractory Three-chamber social approach test 6-8 weeks Silverman JL , et al. (2009)

M_BTBR_1_inbred_HM_Risperidone-2-H

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with risperidone (0.3 mg/kg) 1 h before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Chadman KK (2010)
Communications - Not Reported - - Chadman KK (2010)
Developmental profile - Not Reported - - Chadman KK (2010)
Emotion Anxiety No Adverse Effect Elevated plus maze test 8-15 weeks Chadman KK (2010)
Homeostasis - Not Reported - - Chadman KK (2010)
Immune response - Not Reported - - Chadman KK (2010)
Learning & memory - Not Reported - - Chadman KK (2010)
Maternal behavior - Not Reported - - Chadman KK (2010)
Molecular profile - Not Reported - - Chadman KK (2010)
Motor phenotype General locomotor activity Side Effect Compartment transitions in three-chambered apparatus 8-15 weeks Chadman KK (2010)
Motor phenotype Hypoactivity Side Effect Elevated plus maze test 8-15 weeks Chadman KK (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Chadman KK (2010)
Neurophysiology - Not Reported - - Chadman KK (2010)
Repetitive behavior - Not Reported - - Chadman KK (2010)
Seizure - Not Reported - - Chadman KK (2010)
Sensory - Not Reported - - Chadman KK (2010)
Social behavior Social approach Refractory Three-chamber social approach test 8-15 weeks Chadman KK (2010)
Social behavior Social memory Side Effect Three-chamber social approach test: social novelty 8-15 weeks Chadman KK (2010)

M_BTBR_1_inbred_HM_Risperidone-3

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with risperidone (0.1 mg/kg) before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Gould GG , et al. (2010)
Communications - Not Reported - - Gould GG , et al. (2010)
Developmental profile - Not Reported - - Gould GG , et al. (2010)
Emotion - Not Reported - - Gould GG , et al. (2010)
Homeostasis - Not Reported - - Gould GG , et al. (2010)
Immune response - Not Reported - - Gould GG , et al. (2010)
Learning & memory - Not Reported - - Gould GG , et al. (2010)
Maternal behavior - Not Reported - - Gould GG , et al. (2010)
Molecular profile - Not Reported - - Gould GG , et al. (2010)
Motor phenotype - Not Reported - - Gould GG , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Gould GG , et al. (2010)
Neurophysiology - Not Reported - - Gould GG , et al. (2010)
Repetitive behavior Repetitive digging Ameliorated Marble-burying test 3-4 months Gould GG , et al. (2010)
Seizure - Not Reported - - Gould GG , et al. (2010)
Sensory - Not Reported - - Gould GG , et al. (2010)
Social behavior Social approach Refractory Three-chamber social approach test 3-4 months Gould GG , et al. (2010)
Social behavior Social memory Side Effect Three-chamber social approach test: social novelty 3-4 months Gould GG , et al. (2010)

M_BTBR_1_inbred_HM_Risperidone-4-H

Model Source:

JAX

Model Type:

RESCUE-Pharmaceutical

Strain of Origin:

BTBR

Mutation:

BTBR mice were i.p. injected with risperidone (0.125 mg/kg) 30 min before tests

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Amodeo DA , et al. (2014)
Communications - Not Reported - - Amodeo DA , et al. (2014)
Developmental profile - Not Reported - - Amodeo DA , et al. (2014)
Emotion - Not Reported - - Amodeo DA , et al. (2014)
Homeostasis - Not Reported - - Amodeo DA , et al. (2014)
Immune response - Not Reported - - Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Restored Spatial discrimination assay: reversal learning: regressive errors 8 weeks Amodeo DA , et al. (2014)
Learning & memory Cognitive flexibility Restored Spatial discrimination assay: reversal learning 8 weeks Amodeo DA , et al. (2014)
Learning & memory Spatial learning No Adverse Effect Spatial discrimination assay: acquisition 8 weeks Amodeo DA , et al. (2014)
Maternal behavior - Not Reported - - Amodeo DA , et al. (2014)
Molecular profile - Not Reported - - Amodeo DA , et al. (2014)
Motor phenotype - Not Reported - - Amodeo DA , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Amodeo DA , et al. (2014)
Neurophysiology - Not Reported - - Amodeo DA , et al. (2014)
Repetitive behavior Perseveration