BTBR
Model Species
Mus musculusStrain Name
BTBR T+ Itpr3tf/JReports
33Inbred Models / Rescue Models
73 / 63Rescue Model
YesModel Summary
The inbred strain BTBR T+ Itpr3tf/J of mice has been used in a 'forward genetics' approach as it was found to have low levels of social interaction. These mice exhibit a 100% absence of corpus callosum and severely reduced hippocampal commissure.
External Links
Reports related to BTBR (33 Reports)
# | Type | Title | Author, Year |
---|---|---|---|
1 | Primary | Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. | Moy SS , et al. (2006) |
2 | Primary | Autism-like behavioral phenotypes in BTBR T? mice. | McFarlane HG , et al. (2007) |
3 | Additional | Social deficits in BTBR T? mice are unchanged by cross-fostering with C57BL/6J mothers. | Yang M , et al. (2007) |
4 | Additional | Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. | Silverman JL , et al. (2009) |
5 | Additional | General and social anxiety in the BTBR T tf/J mouse strain. | Pobbe RL , et al. (2010) |
6 | Additional | Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism. | Chadman KK (2010) |
7 | Additional | Social peers rescue autism-relevant sociability deficits in adolescent mice. | Yang M , et al. (2010) |
8 | Additional | A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T tf/J mice. | Defensor EB , et al. (2010) |
9 | Additional | Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T? mouse soc... | Gould GG , et al. (2010) |
10 | Additional | Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders. | Onaivi ES , et al. (2011) |
11 | Additional | Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. | Silverman JL , et al. (2012) |
12 | Additional | Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. | Gould GG , et al. (2012) |
13 | Additional | Developmental exposure to mercury chloride does not impair social behavior of C57BL/6 BTBR F(1) mice. | Zhang Y , et al. (2012) |
14 | Additional | Co-learning facilitates memory in mice: a new avenue in social neuroscience. | Lipina TV and Roder JC (2012) |
15 | Additional | AMPAKINE enhancement of social interaction in the BTBR mouse model of autism. | Silverman JL , et al. (2012) |
16 | Additional | Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism. | Silverman JL , et al. (2012) |
17 | Additional | The maternal autoimmune environment affects the social behavior of offspring. | Zhang Y , et al. (2013) |
18 | Additional | D-Cycloserine improves sociability in the BTBR T Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling. | Burket JA , et al. (2013) |
19 | Additional | Ketogenic diet improves core symptoms of autism in BTBR mice. | Ruskin DN , et al. (2013) |
20 | Additional | Cued and contextual fear conditioning in BTBR mice is improved with training or atomoxetine. | Stapley NW , et al. (2013) |
21 | Additional | Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. | Karvat G and Kimchi T (2013) |
22 | Additional | Rapamycin improves sociability in the BTBR T()Itpr3(tf)/J mouse model of autism spectrum disorders. | Burket JA , et al. (2013) |
23 | Additional | Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism. | Seese RR , et al. (2014) |
24 | Additional | Enhancement of inhibitory neurotransmission by GABAA receptors having 2,3-subunits ameliorates behavioral deficits in a mouse model of autism. | Han S , et al. (2014) |
25 | Additional | Risperidone and the 5-HT2A receptor antagonist M100907 improve probabilistic reversal learning in BTBR T tf/J mice. | Amodeo DA , et al. (2014) |
26 | Additional | Sensory integration in mouse insular cortex reflects GABA circuit maturation. | Gogolla N , et al. (2014) |
27 | Additional | Enhanced synapse remodelling as a common phenotype in mouse models of autism. | Isshiki M , et al. (2014) |
28 | Additional | Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice. | Wu J , et al. (2016) |
29 | Additional | Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORt) signaling in a BTBR T Itpr3tf/... | Ansari MA , et al. (2017) |
30 | Additional | Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism. | Golubeva AV , et al. (2017) |
31 | Additional | Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. | Sgritta M , et al. (2018) |
32 | Additional | Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism. | Rhine MA , et al. (2019) |
33 | Additional | The Liver X Receptor Agonist TO901317 Ameliorates Behavioral Deficits in Two Mouse Models of Autism. | Cai Y , et al. (2019) |
M_BTBR_1_INBRED_HM
Model Source:
JAX
Model Type:
Inbred
Strain of Origin:
BTBR
Mutation:
The BTBR T+ Itpr3tf/J strain was derived from the inbred strain BTBR (Black and Tan BRachyury) that carried the mutations at (nonagouti; black and tan), Itpr3tf (inositol 1,4,5-triphosphate receptor 3; tufted), and T (brachyury).
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Moy SS , et al. (2006) |
Communications | Audible vocalization | No change | General observations | 4-5 weeks | Moy SS , et al. (2006) |
Developmental profile | Coat color | No change | General observations | 4-5 weeks | Moy SS , et al. (2006) |
Developmental profile | General characteristics | No change | General observations | 4-5 weeks | Moy SS , et al. (2006) |
Developmental profile | Size/growth | No change | General observations | 4-5 weeks | Moy SS , et al. (2006) |
Emotion | Anxiety | Increased | Open field test | 5-6 weeks | Moy SS , et al. (2006) |
Emotion | Anxiety | Increased | Elevated plus maze test | 8-10 weeks | Moy SS , et al. (2006) |
Emotion | Fear response | No change | General observations | 4-5 weeks | Moy SS , et al. (2006) |
Immune response | - | Not reported | - | - | Moy SS , et al. (2006) |
Learning & memory | Cognitive flexibility | No change | T-maze test | 3-4 months | Moy SS , et al. (2006) |
Learning & memory | Cognitive flexibility | No change | Morris water maze test | 4-6 months | Moy SS , et al. (2006) |
Learning & memory | Reward reinforced choice behavior | No change | T-maze test | 3-4 months | Moy SS , et al. (2006) |
Learning & memory | Spatial reference memory | No change | Morris water maze test | 4-6 months | Moy SS , et al. (2006) |
Learning & memory | Spatial working memory | No change | Morris water maze test | 4-6 months | Moy SS , et al. (2006) |
Maternal behavior | - | Not reported | - | - | Moy SS , et al. (2006) |
Molecular profile | - | Not reported | - | - | Moy SS , et al. (2006) |
Motor phenotype | General locomotor activity | No change | Open field test | 5-6 weeks | Moy SS , et al. (2006) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 5-6 weeks | Moy SS , et al. (2006) |
Motor phenotype | Motor coordination and balance | No change | Accelerating rotarod test | 5-6 weeks | Moy SS , et al. (2006) |
Motor phenotype | Spontaneous movement | No change | Open field test | 5-6 weeks | Moy SS , et al. (2006) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Moy SS , et al. (2006) |
Neurophysiology | - | Not reported | - | - | Moy SS , et al. (2006) |
Physiological parameters | - | Not reported | - | - | Moy SS , et al. (2006) |
Repetitive behavior | - | Not reported | - | - | Moy SS , et al. (2006) |
Seizure | - | Not reported | - | - | Moy SS , et al. (2006) |
Sensory | Hearing | No change | Preyer's reflex test | 4-5 weeks | Moy SS , et al. (2006) |
Sensory | Olfaction | No change | Buried food test | 7-8 weeks | Moy SS , et al. (2006) |
Social behavior | Huddling behavior | No change | Home cage behavior | 3-4 weeks | Moy SS , et al. (2006) |
Social behavior | Nest building behavior | No change | Nest building assay | 4-5 weeks | Moy SS , et al. (2006) |
Social behavior | Rearing behavior | No change | Open field test | 5-6 weeks | Moy SS , et al. (2006) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6-7 weeks | Moy SS , et al. (2006) |
Social behavior | Social memory | No change | Three-chamber social approach test | 6-7 weeks | Moy SS , et al. (2006) |
Circadian sleep/wake cycle | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Communications | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Developmental profile | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Emotion | Anxiety | Decreased | Elevated zero maze test | Unreported | McFarlane HG , et al. (2007) |
Immune response | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Learning & memory | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Maternal behavior | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Molecular profile | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Motor phenotype | General locomotor activity | Increased | Open field test | 3 weeks | McFarlane HG , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Neurophysiology | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Physiological parameters | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Repetitive behavior | Self scratching | Increased | Grooming behavior assessments | P18, P28, P38, P60 | McFarlane HG , et al. (2007) |
Seizure | - | Not reported | - | - | McFarlane HG , et al. (2007) |
Sensory | Olfaction | No change | Three-chamber social approach test | Unreported | McFarlane HG , et al. (2007) |
Social behavior | Juvenile play | Decreased | Reciprocal social interaction test | 3 weeks | McFarlane HG , et al. (2007) |
Social behavior | Self grooming: social context | Increased | Reciprocal social interaction test | 3 weeks | McFarlane HG , et al. (2007) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6 weeks, adult | McFarlane HG , et al. (2007) |
Social behavior | Social memory | No change | Three-chamber social approach test | Unreported | McFarlane HG , et al. (2007) |
Social behavior | Social transmission of food preference | Decreased | Social transmission of food preference | Unreported | McFarlane HG , et al. (2007) |
Circadian sleep/wake cycle | - | Not reported | - | - | Yang M , et al. (2007) |
Communications | - | Not reported | - | - | Yang M , et al. (2007) |
Developmental profile | - | Not reported | - | - | Yang M , et al. (2007) |
Emotion | - | Not reported | - | - | Yang M , et al. (2007) |
Immune response | - | Not reported | - | - | Yang M , et al. (2007) |
Learning & memory | - | Not reported | - | - | Yang M , et al. (2007) |
Maternal behavior | - | Not reported | - | - | Yang M , et al. (2007) |
Molecular profile | - | Not reported | - | - | Yang M , et al. (2007) |
Motor phenotype | Self grooming: home cage/familiar environment | Increased | Home cage behavior | Adult | Yang M , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Yang M , et al. (2007) |
Neurophysiology | - | Not reported | - | - | Yang M , et al. (2007) |
Physiological parameters | - | Not reported | - | - | Yang M , et al. (2007) |
Repetitive behavior | - | Not reported | - | - | Yang M , et al. (2007) |
Seizure | - | Not reported | - | - | Yang M , et al. (2007) |
Sensory | - | Not reported | - | - | Yang M , et al. (2007) |
Social behavior | Juvenile play | Decreased | Reciprocal social interaction test | 3 weeks | Yang M , et al. (2007) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | Adult | Yang M , et al. (2007) |
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Increased | Open field test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Increased | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
Circadian sleep/wake cycle | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Communications | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Developmental profile | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Emotion | Anxiety | Decreased | Mouse defense test battery | 14-17 weeks | Pobbe RL , et al. (2010) |
Emotion | Anxiety | Decreased | Elevated zero maze test | 14-17 weeks | Pobbe RL , et al. (2010) |
Emotion | Anxiety | Increased | Elevated plus maze test | 14-17 weeks | Pobbe RL , et al. (2010) |
Emotion | Fear response | Increased | Mouse defense test battery | 14-17 weeks | Pobbe RL , et al. (2010) |
Emotion | Fear response | Increased | Mouse defense test battery | 14-17 weeks | Pobbe RL , et al. (2010) |
Emotion | Fear response | Increased | Mouse defense test battery | 14-17 weeks | Pobbe RL , et al. (2010) |
Immune response | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Learning & memory | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Molecular profile | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Repetitive behavior | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Seizure | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Sensory | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 14-17 weeks | Pobbe RL , et al. (2010) |
Circadian sleep/wake cycle | - | Not reported | - | - | Chadman KK (2010) |
Communications | - | Not reported | - | - | Chadman KK (2010) |
Developmental profile | - | Not reported | - | - | Chadman KK (2010) |
Emotion | Anxiety | No change | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Immune response | - | Not reported | - | - | Chadman KK (2010) |
Learning & memory | - | Not reported | - | - | Chadman KK (2010) |
Maternal behavior | - | Not reported | - | - | Chadman KK (2010) |
Molecular profile | - | Not reported | - | - | Chadman KK (2010) |
Motor phenotype | - | Not reported | - | - | Chadman KK (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Chadman KK (2010) |
Neurophysiology | - | Not reported | - | - | Chadman KK (2010) |
Physiological parameters | - | Not reported | - | - | Chadman KK (2010) |
Repetitive behavior | - | Not reported | - | - | Chadman KK (2010) |
Seizure | - | Not reported | - | - | Chadman KK (2010) |
Sensory | - | Not reported | - | - | Chadman KK (2010) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Social behavior | Social memory | No change | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Circadian sleep/wake cycle | - | Not reported | - | - | Yang M , et al. (2010) |
Communications | - | Not reported | - | - | Yang M , et al. (2010) |
Developmental profile | - | Not reported | - | - | Yang M , et al. (2010) |
Emotion | - | Not reported | - | - | Yang M , et al. (2010) |
Immune response | - | Not reported | - | - | Yang M , et al. (2010) |
Learning & memory | - | Not reported | - | - | Yang M , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Yang M , et al. (2010) |
Molecular profile | - | Not reported | - | - | Yang M , et al. (2010) |
Motor phenotype | General locomotor activity | No change | Three-chamber social approach test | 6-8 weeks | Yang M , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Yang M , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Yang M , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Yang M , et al. (2010) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 6-8 weeks | Yang M , et al. (2010) |
Seizure | - | Not reported | - | - | Yang M , et al. (2010) |
Sensory | - | Not reported | - | - | Yang M , et al. (2010) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6-8 weeks | Yang M , et al. (2010) |
Circadian sleep/wake cycle | - | Not reported | - | - | Defensor EB , et al. (2010) |
Communications | - | Not reported | - | - | Defensor EB , et al. (2010) |
Developmental profile | - | Not reported | - | - | Defensor EB , et al. (2010) |
Emotion | Anxiety | Increased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Immune response | - | Not reported | - | - | Defensor EB , et al. (2010) |
Learning & memory | - | Not reported | - | - | Defensor EB , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Defensor EB , et al. (2010) |
Molecular profile | - | Not reported | - | - | Defensor EB , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Defensor EB , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Defensor EB , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Defensor EB , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Defensor EB , et al. (2010) |
Repetitive behavior | - | Not reported | - | - | Defensor EB , et al. (2010) |
Seizure | - | Not reported | - | - | Defensor EB , et al. (2010) |
Sensory | - | Not reported | - | - | Defensor EB , et al. (2010) |
Social behavior | Rearing behavior | Decreased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Increased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Increased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social withdrawal | Increased | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2010) |
Communications | - | Not reported | - | - | Gould GG , et al. (2010) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2010) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2010) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2010) |
Molecular profile | Protein binding | Increased | Agonist-stimulated g-protein coupling assay | 4 months | Gould GG , et al. (2010) |
Molecular profile | Protein binding | No change | Agonist-stimulated g-protein coupling assay | 4 months | Gould GG , et al. (2010) |
Molecular profile | Protein binding: bmax of receptor | Decreased | Receptor saturation binding assay | 4 months | Gould GG , et al. (2010) |
Molecular profile | Protein binding: kd of receptor | Increased | Receptor saturation binding assay | 4 months | Gould GG , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Gould GG , et al. (2010) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: serotonin | No change | Radial maze test | Unreported | Gould GG , et al. (2010) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuroreceptor levels: serotonin | No change | Radial maze test | Unreported | Gould GG , et al. (2010) |
Neurophysiology | Neurotransporter activity | Decreased | Radial maze test | 4 months | Gould GG , et al. (2010) |
Neurophysiology | Neurotransporter activity | No change | Radial maze test | Unreported | Gould GG , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2010) |
Repetitive behavior | Repetitive digging | No change | Marble-burying test | 3-4 months | Gould GG , et al. (2010) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2010) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2010) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
Social behavior | Social memory | No change | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
Circadian sleep/wake cycle | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Communications | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Developmental profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Emotion | Depression | Increased | Forced swim test | Adult | Onaivi ES , et al. (2011) |
Immune response | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Learning & memory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Maternal behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Molecular profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Motor phenotype | General locomotor activity | Increased | Running wheel test | Adult | Onaivi ES , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: catecholamines | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Physiological parameters | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Repetitive behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Seizure | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Sensory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Social behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Increased | Home cage behavior | 9-10 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | Repetitive digging | Increased | Three-chamber social approach test | 8-16 weeks | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Self grooming: social context | Increased | Three-chamber social approach test | 8-16 weeks | Silverman JL , et al. (2012) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 9-10 weeks | Silverman JL , et al. (2012) |
Social behavior | Social interaction | Decreased | Three-chamber social approach test | 8-16 weeks | Silverman JL , et al. (2012) |
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2012) |
Communications | - | Not reported | - | - | Gould GG , et al. (2012) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2012) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2012) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2012) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2012) |
Molecular profile | Protein binding: bmax of receptor | No change | Radioligand binding studies | Unreported | Gould GG , et al. (2012) |
Molecular profile | Protein binding: kd of receptor | No change | Radioligand binding studies | Unreported | Gould GG , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Radioligand binding studies | 3-4 months | Gould GG , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Radioligand binding studies | 3-4 months | Gould GG , et al. (2012) |
Molecular profile | Protein expression: in situ protein expression | Increased | Autoradiographic analysis | 3-4 months | Gould GG , et al. (2012) |
Molecular profile | Protein expression: in situ protein expression | No change | Autoradiographic analysis | 3-4 months | Gould GG , et al. (2012) |
Molecular profile | Protein expression: in situ protein expression | No change | Autoradiographic analysis | 3-4 months | Gould GG , et al. (2012) |
Motor phenotype | - | Not reported | - | - | Gould GG , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gould GG , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Gould GG , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Gould GG , et al. (2012) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2012) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2012) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
Social behavior | Social memory | No change | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
Circadian sleep/wake cycle | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Decreased | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Increased | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Increased | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Developmental profile | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Emotion | Anxiety | No change | Elevated plus maze test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Emotion | Response to novelty | No change | Object-place recognition test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Immune response | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Learning & memory | Object recognition memory | Decreased | Object-place recognition test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Maternal behavior | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Molecular profile | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Motor phenotype | General locomotor activity | Increased | Open field test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Motor phenotype | General locomotor activity | Increased | Object-place recognition test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Motor phenotype | Hyperactivity | Increased | Elevated plus maze test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Increased | Object-place recognition test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Neurophysiology | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Physiological parameters | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Repetitive behavior | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Seizure | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Sensory | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Social behavior | Rearing behavior | No change | Object-place recognition test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | Ultrasonic vocalization | Decreased | Monitoring ultrasonic vocalizations | 6-8 weeks | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | Increased | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 6-8 weeks | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Increased | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Increased | Grooming behavior assessments | 7 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6 weeks | Silverman JL , et al. (2012) |
Social behavior | Social interaction: opposite sex | Decreased | Reciprocal social interaction test | 6-8 weeks | Silverman JL , et al. (2012) |
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | Increased | Open field test | 6-8 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Decreased | Open field test | 6-8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Increased | Open field test | 6-8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Increased | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2012) |
Circadian sleep/wake cycle | - | Not reported | - | - | Zhang Y , et al. (2013) |
Communications | - | Not reported | - | - | Zhang Y , et al. (2013) |
Developmental profile | - | Not reported | - | - | Zhang Y , et al. (2013) |
Emotion | - | Not reported | - | - | Zhang Y , et al. (2013) |
Immune response | Adaptive immune response: b cells antibody production | Increased | Elisa | Unreported | Zhang Y , et al. (2013) |
Immune response | Adaptive immune response: leukocyte types | Decreased | Flow cytometric analysis | Unreported | Zhang Y , et al. (2013) |
Immune response | Adaptive immune response: leukocyte types | Increased | Flow cytometric analysis | Unreported | Zhang Y , et al. (2013) |
Immune response | Adaptive immune response: t cells | Increased | Elisa | Unreported | Zhang Y , et al. (2013) |
Learning & memory | - | Not reported | - | - | Zhang Y , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Zhang Y , et al. (2013) |
Molecular profile | - | Not reported | - | - | Zhang Y , et al. (2013) |
Motor phenotype | - | Not reported | - | - | Zhang Y , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Zhang Y , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Zhang Y , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Zhang Y , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Zhang Y , et al. (2013) |
Seizure | - | Not reported | - | - | Zhang Y , et al. (2013) |
Sensory | - | Not reported | - | - | Zhang Y , et al. (2013) |
Social behavior | - | Not reported | - | - | Zhang Y , et al. (2013) |
Circadian sleep/wake cycle | - | Not reported | - | - | Burket JA , et al. (2013) |
Communications | - | Not reported | - | - | Burket JA , et al. (2013) |
Developmental profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Emotion | - | Not reported | - | - | Burket JA , et al. (2013) |
Immune response | - | Not reported | - | - | Burket JA , et al. (2013) |
Learning & memory | - | Not reported | - | - | Burket JA , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Molecular profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Motor phenotype | General locomotor activity | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Burket JA , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Burket JA , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Burket JA , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Seizure | - | Not reported | - | - | Burket JA , et al. (2013) |
Sensory | - | Not reported | - | - | Burket JA , et al. (2013) |
Social behavior | Juvenile play | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Rearing behavior | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Self grooming: social context | No change | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social interaction | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social withdrawal | Increased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Circadian sleep/wake cycle | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Communications | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Developmental profile | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Emotion | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Immune response | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Learning & memory | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Molecular profile | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Motor phenotype | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Seizure | Electroencephalogram (eeg): signature of seizure/epilepsy | No change | Electroencephalogram (eeg) | 8-10 weeks | Ruskin DN , et al. (2013) |
Seizure | Seizure threshold | Decreased | Observation of electrically induced seizures | 8-10 weeks | Ruskin DN , et al. (2013) |
Seizure | Seizure threshold | Increased | Observation of chemically induced seizures | 8-10 weeks | Ruskin DN , et al. (2013) |
Seizure | Seizure threshold | No change | Observation of chemically induced seizures | 8-10 weeks | Ruskin DN , et al. (2013) |
Seizure | Seizure threshold | No change | Observation of chemically induced seizures | 8-10 weeks | Ruskin DN , et al. (2013) |
Seizure | Seizures | No change | General observations | 8-10 weeks | Ruskin DN , et al. (2013) |
Sensory | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 8-10 weeks | Ruskin DN , et al. (2013) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 8-10 weeks | Ruskin DN , et al. (2013) |
Social behavior | Social transmission of food preference | Decreased | Social transmission of food preference | 8-10 weeks | Ruskin DN , et al. (2013) |
Circadian sleep/wake cycle | - | Not reported | - | - | Stapley NW , et al. (2013) |
Communications | - | Not reported | - | - | Stapley NW , et al. (2013) |
Developmental profile | - | Not reported | - | - | Stapley NW , et al. (2013) |
Emotion | - | Not reported | - | - | Stapley NW , et al. (2013) |
Immune response | - | Not reported | - | - | Stapley NW , et al. (2013) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | 3-7 months | Stapley NW , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Molecular profile | - | Not reported | - | - | Stapley NW , et al. (2013) |
Motor phenotype | - | Not reported | - | - | Stapley NW , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Stapley NW , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Stapley NW , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Stapley NW , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Seizure | - | Not reported | - | - | Stapley NW , et al. (2013) |
Sensory | - | Not reported | - | - | Stapley NW , et al. (2013) |
Social behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Circadian sleep/wake cycle | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Communications | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Developmental profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Emotion | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Immune response | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Learning & memory | Cognitive flexibility | Decreased | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Maternal behavior | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Molecular profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Motor phenotype | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Neurophysiology | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Physiological parameters | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Repetitive behavior | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Seizure | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Sensory | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 8 weeks | Karvat G and Kimchi T (2013) |
Social behavior | Social interaction | Decreased | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 8 weeks | Karvat G and Kimchi T (2013) |
Circadian sleep/wake cycle | - | Not reported | - | - | Burket JA , et al. (2013) |
Communications | - | Not reported | - | - | Burket JA , et al. (2013) |
Developmental profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Emotion | - | Not reported | - | - | Burket JA , et al. (2013) |
Immune response | - | Not reported | - | - | Burket JA , et al. (2013) |
Learning & memory | - | Not reported | - | - | Burket JA , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Molecular profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Motor phenotype | General locomotor activity | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Burket JA , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Burket JA , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Burket JA , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Seizure | - | Not reported | - | - | Burket JA , et al. (2013) |
Sensory | - | Not reported | - | - | Burket JA , et al. (2013) |
Social behavior | Juvenile play | No change | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Rearing behavior | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Self grooming: social context | No change | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social interaction | Increased | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social withdrawal | No change | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Circadian sleep/wake cycle | - | Not reported | - | - | Seese RR , et al. (2014) |
Communications | - | Not reported | - | - | Seese RR , et al. (2014) |
Developmental profile | - | Not reported | - | - | Seese RR , et al. (2014) |
Emotion | - | Not reported | - | - | Seese RR , et al. (2014) |
Immune response | - | Not reported | - | - | Seese RR , et al. (2014) |
Learning & memory | Object recognition memory | Decreased | Object-place recognition test | 4-6 months | Seese RR , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
Molecular profile | Signaling | Decreased | Western blot | 4-6 months | Seese RR , et al. (2014) |
Molecular profile | Signaling | Decreased | Fluorescence tomography | 4-6 months | Seese RR , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Seese RR , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Seese RR , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Seese RR , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Seese RR , et al. (2014) |
Repetitive behavior | Repetitive digging | Increased | Object-place recognition test | 4-6 months | Seese RR , et al. (2014) |
Seizure | - | Not reported | - | - | Seese RR , et al. (2014) |
Sensory | - | Not reported | - | - | Seese RR , et al. (2014) |
Social behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | Anxiety | Decreased | Open field test | 6-10 months | Han S , et al. (2014) |
Emotion | Anxiety | Decreased | Elevated plus maze test | 6-10 months | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning | Decreased | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Decreased | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Spatial reference memory | Decreased | Barnes maze test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Spatial working memory | Decreased | Barnes maze test | 6-10 months | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | Increased | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | Miniature post synaptic currents: excitatory | Increased | Whole-cell patch clamp | 3 weeks | Han S , et al. (2014) |
Neurophysiology | Miniature post synaptic currents: inhibitory | No change | Whole-cell patch clamp | 3 weeks | Han S , et al. (2014) |
Neurophysiology | Synaptic transmission: excitatory | No change | Whole-cell patch clamp | 3 weeks | Han S , et al. (2014) |
Neurophysiology | Synaptic transmission: excitatory | Increased | Whole-cell patch clamp | 3 weeks | Han S , et al. (2014) |
Neurophysiology | Synaptic transmission: inhibitory | Decreased | Whole-cell patch clamp | 3 weeks | Han S , et al. (2014) |
Neurophysiology | Synaptic transmission: inhibitory | No change | Whole-cell patch clamp | 3 weeks | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | Circling | Increased | Open field test | 6-10 months | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 6-10 months | Han S , et al. (2014) |
Circadian sleep/wake cycle | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Communications | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Developmental profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Emotion | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Immune response | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Decreased | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Spatial learning | No change | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Molecular profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Repetitive behavior | Perseveration | No change | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Seizure | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Sensory | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Social behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Circadian sleep/wake cycle | - | Not reported | - | - | Gogolla N , et al. (2014) |
Communications | - | Not reported | - | - | Gogolla N , et al. (2014) |
Developmental profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Emotion | - | Not reported | - | - | Gogolla N , et al. (2014) |
Immune response | - | Not reported | - | - | Gogolla N , et al. (2014) |
Learning & memory | - | Not reported | - | - | Gogolla N , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Molecular profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Gogolla N , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Perineuronal net morphology | Decreased | Immunohistochemistry | Unreported | Gogolla N , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: inhibitory | Decreased | Immunohistochemistry | Unreported | Gogolla N , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synaptic morphology | Decreased | Immunohistochemistry | Unreported | Gogolla N , et al. (2014) |
Neurophysiology | Miniature post synaptic current amplitude: inhibitory | No change | Whole-cell patch clamp | Unreported | Gogolla N , et al. (2014) |
Neurophysiology | Miniature post synaptic current frequency: inhibitory | Decreased | Whole-cell patch clamp | Unreported | Gogolla N , et al. (2014) |
Neurophysiology | Neurotransmitter release: serotonin | No change | High-performance liquid chromatography (hplc) | Adult | Gogolla N , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Gogolla N , et al. (2014) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | Adult | Gogolla N , et al. (2014) |
Seizure | - | Not reported | - | - | Gogolla N , et al. (2014) |
Sensory | Multisensory integration: sensory neurons of insular cortex: auditory-tactile | Decreased | Quantification of degree of integration | Adult | Gogolla N , et al. (2014) |
Sensory | Sensory-evoked response: excitation: auditory stimulus | No change | Measurement of area of activation (roi) in the insular cortex | Adult | Gogolla N , et al. (2014) |
Sensory | Sensory-evoked response: excitation: auditory stimulus | Increased | Measurement of area of activation (roi) in the insular cortex | Adult | Gogolla N , et al. (2014) |
Sensory | Sensory-evoked response: excitation: auditory stimulus | Increased | Measurement of area of activation (roi) in the insular cortex | P15-P21 | Gogolla N , et al. (2014) |
Social behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Circadian sleep/wake cycle | - | Not reported | - | - | Wu J , et al. (2016) |
Communications | - | Not reported | - | - | Wu J , et al. (2016) |
Developmental profile | - | Not reported | - | - | Wu J , et al. (2016) |
Emotion | - | Not reported | - | - | Wu J , et al. (2016) |
Immune response | - | Not reported | - | - | Wu J , et al. (2016) |
Learning & memory | - | Not reported | - | - | Wu J , et al. (2016) |
Maternal behavior | - | Not reported | - | - | Wu J , et al. (2016) |
Molecular profile | Protein phosphorylation | No change | Western blot | 12 weeks | Wu J , et al. (2016) |
Molecular profile | Signaling: mtor | No change | Western blot | 12 weeks | Wu J , et al. (2016) |
Molecular profile | Signaling: mtor | Decreased | Western blot | 12 weeks | Wu J , et al. (2016) |
Motor phenotype | General locomotor activity | Increased | Open field test | 12 weeks | Wu J , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Wu J , et al. (2016) |
Neurophysiology | - | Not reported | - | - | Wu J , et al. (2016) |
Physiological parameters | - | Not reported | - | - | Wu J , et al. (2016) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 12 weeks | Wu J , et al. (2016) |
Seizure | - | Not reported | - | - | Wu J , et al. (2016) |
Sensory | - | Not reported | - | - | Wu J , et al. (2016) |
Social behavior | Social interaction | Increased | Partition test | 12 weeks | Wu J , et al. (2016) |
Social behavior | Social interaction | No change | Partition test | 12 weeks | Wu J , et al. (2016) |
Circadian sleep/wake cycle | - | Not reported | - | - | Ansari MA , et al. (2017) |
Communications | - | Not reported | - | - | Ansari MA , et al. (2017) |
Developmental profile | - | Not reported | - | - | Ansari MA , et al. (2017) |
Emotion | - | Not reported | - | - | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Decreased | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Increased | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Learning & memory | - | Not reported | - | - | Ansari MA , et al. (2017) |
Maternal behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Decreased | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Increased | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Motor phenotype | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neurophysiology | - | Not reported | - | - | Ansari MA , et al. (2017) |
Physiological parameters | - | Not reported | - | - | Ansari MA , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 11 weeks | Ansari MA , et al. (2017) |
Seizure | - | Not reported | - | - | Ansari MA , et al. (2017) |
Sensory | Pain or nociception | Decreased | Hot plate test | 11 weeks | Ansari MA , et al. (2017) |
Social behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
Circadian sleep/wake cycle | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Communications | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Developmental profile | Adrenal cortex morphology | Abnormal | General observations | 14 weeks | Golubeva AV , et al. (2017) |
Emotion | Anxiety | No change | Open field test | 9 weeks | Golubeva AV , et al. (2017) |
Emotion | Anxiety | Increased | Elevated plus maze test | 10 weeks | Golubeva AV , et al. (2017) |
Emotion | Anxiety | Increased | General observations | 9-10 weeks | Golubeva AV , et al. (2017) |
Emotion | Depression | Abnormal | Forced swim test | 13 weeks | Golubeva AV , et al. (2017) |
Immune response | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Learning & memory | Object recognition memory | Decreased | Novel object recognition test | 9 weeks | Golubeva AV , et al. (2017) |
Maternal behavior | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 8 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 8 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 8 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 9 weeks | Golubeva AV , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: enteric neurons | Abnormal | Immunofluorescence staining | 14 weeks | Golubeva AV , et al. (2017) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Neuronal number: enteric neurons | Decreased | Immunofluorescence staining | 14 weeks | Golubeva AV , et al. (2017) |
Neurophysiology | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Physiological parameters | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Physiological parameters | Bioactive compound levels: bile acids | Abnormal | Liquid chromatography-mass spectrometry (lc-ms) | 8 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Bioactive compound levels: bile acids | Decreased | Liquid chromatography-mass spectrometry (lc-ms) | 8 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Bioactive compound levels: serotonin | Decreased | High-performance liquid chromatography (hplc) | 14 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Bioactive compound levels: serotonin | Decreased | Quantitative pcr (qrt-pcr) | 14 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Bioactive compound levels: short chain fatty acids | Abnormal | Gas chromotography (gc) | 14 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Digestive system function: gastrointestinal motility | Decreased | General observations | 12-14 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Digestive system function: gastrointestinal motility | Decreased | General observations | 8 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Digestive system function: intestinal barrier: intestinal permeability | Abnormal | Intestinal permeability test | 14 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Hormone levels | Decreased | Radioimmunoassay (ria) | 14 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Hormone levels | Increased | Elisa | 13 weeks | Golubeva AV , et al. (2017) |
Physiological parameters | Intestinal microbiota composition: species diversity | Decreased | 16s rrna gene sequence analysis for identification of bacteria | 14 weeks | Golubeva AV , et al. (2017) |
Repetitive behavior | Repetitive digging | Increased | Marble-burying test | 10 weeks | Golubeva AV , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 8 weeks | Golubeva AV , et al. (2017) |
Seizure | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Sensory | - | Not reported | - | - | Golubeva AV , et al. (2017) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 8 weeks | Golubeva AV , et al. (2017) |
Social behavior | Social interaction | Decreased | Resident-intruder test | 12 weeks | Golubeva AV , et al. (2017) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 8 weeks | Golubeva AV , et al. (2017) |
Social behavior | Social transmission of food preference | Decreased | Social transmission of food preference | 11 weeks | Golubeva AV , et al. (2017) |
Circadian sleep/wake cycle | - | Not reported | - | - | Rhine MA , et al. (2019) |
Communications | Ultrasonic vocalization: interaction induced: opposite sex stimulus | Decreased | Monitoring ultrasonic vocalizations | 2-3 months | Rhine MA , et al. (2019) |
Developmental profile | - | Not reported | - | - | Rhine MA , et al. (2019) |
Emotion | Anxiety | Decreased | Elevated plus maze test | 2-3 months | Rhine MA , et al. (2019) |
Emotion | Anxiety | Decreased | Light-dark exploration test | 2-3 months | Rhine MA , et al. (2019) |
Emotion | Exploratory activity | Decreased | Novel cage test | 2-3 months | Rhine MA , et al. (2019) |
Immune response | - | Not reported | - | - | Rhine MA , et al. (2019) |
Learning & memory | - | Not reported | - | - | Rhine MA , et al. (2019) |
Maternal behavior | - | Not reported | - | - | Rhine MA , et al. (2019) |
Molecular profile | - | Not reported | - | - | Rhine MA , et al. (2019) |
Motor phenotype | General locomotor activity | No change | Three-chamber social approach test | 2-3 months | Rhine MA , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | Increased | Open field test | 2-3 months | Rhine MA , et al. (2019) |
Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-3 months | Rhine MA , et al. (2019) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Rhine MA , et al. (2019) |
Neurophysiology | - | Not reported | - | - | Rhine MA , et al. (2019) |
Physiological parameters | - | Not reported | - | - | Rhine MA , et al. (2019) |
Repetitive behavior | Repetitive digging | Increased | Observation of repetitive behavior | 2-3 months | Rhine MA , et al. (2019) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 2-3 months | Rhine MA , et al. (2019) |
Seizure | - | Not reported | - | - | Rhine MA , et al. (2019) |
Sensory | - | Not reported | - | - | Rhine MA , et al. (2019) |
Social behavior | Self grooming: social context | Increased | Grooming behavior assessments | 2-3 months | Rhine MA , et al. (2019) |
Social behavior | Social approach | No change | Three-chamber social approach test | 2-3 months | Rhine MA , et al. (2019) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-3 months | Rhine MA , et al. (2019) |
Social behavior | Social interaction: opposite sex | Decreased | Reciprocal social interaction test | 2-3 months | Rhine MA , et al. (2019) |
Circadian sleep/wake cycle | - | Not reported | - | - | Cai Y , et al. (2019) |
Communications | - | Not reported | - | - | Cai Y , et al. (2019) |
Developmental profile | - | Not reported | - | - | Cai Y , et al. (2019) |
Emotion | - | Not reported | - | - | Cai Y , et al. (2019) |
Immune response | - | Not reported | - | - | Cai Y , et al. (2019) |
Learning & memory | - | Not reported | - | - | Cai Y , et al. (2019) |
Maternal behavior | - | Not reported | - | - | Cai Y , et al. (2019) |
Molecular profile | Gene expression | No change | Quantitative pcr (qrt-pcr) | P15 | Cai Y , et al. (2019) |
Motor phenotype | - | Not reported | - | - | Cai Y , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Decreased | Immunohistochemistry | Adult | Cai Y , et al. (2019) |
Neurophysiology | - | Not reported | - | - | Cai Y , et al. (2019) |
Physiological parameters | - | Not reported | - | - | Cai Y , et al. (2019) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 8 weeks | Cai Y , et al. (2019) |
Seizure | - | Not reported | - | - | Cai Y , et al. (2019) |
Sensory | - | Not reported | - | - | Cai Y , et al. (2019) |
Social behavior | Rearing behavior | No change | Novel cage test | 8 weeks | Cai Y , et al. (2019) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 8 weeks | Cai Y , et al. (2019) |
M_BTBR_1_INBRED_HM_ACETAMINOPHEN
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with acetaminophen (100 mg/kg in 0.9 % saline)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2012) |
Communications | - | Not reported | - | - | Gould GG , et al. (2012) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2012) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2012) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2012) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2012) |
Molecular profile | Protein expression level evidence | Increased | Gas chromatography-mass spectrometry (gc-ms) | 3-4 months | Gould GG , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Gas chromatography-mass spectrometry (gc-ms) | 3-4 months | Gould GG , et al. (2012) |
Molecular profile | Protein expression level evidence | No change | Gas chromatography-mass spectrometry (gc-ms) | 3-4 months | Gould GG , et al. (2012) |
Motor phenotype | - | Not reported | - | - | Gould GG , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gould GG , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Gould GG , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2012) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | 3-4 months | Gould GG , et al. (2012) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2012) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2012) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
M_BTBR_1_INBRED_HM_AMPHETAMINE
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR male mice were i.p. injected with Amphetamine (2.0 mg/kg in saline)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | Refractory | Open field test | 6-8 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 6-8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 6-8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Restored | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_AMPHETAMINE_2
Model Source:
Not Specified
Model Type:
Pharmaceutical intervention
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with D-amphetamine (5.0 mg/kg) 10 min before testing
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Communications | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Developmental profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Emotion | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Immune response | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Learning & memory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Maternal behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Molecular profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Motor phenotype | General locomotor activity | No change | Running wheel test | Adult | Onaivi ES , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Neurophysiology | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Physiological parameters | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Repetitive behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Seizure | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Sensory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Social behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
M_BTBR_1_INBRED_HM_ATOMOXETINE
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR male mice were i.p. injected with atomoxetine (2 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Stapley NW , et al. (2013) |
Communications | - | Not reported | - | - | Stapley NW , et al. (2013) |
Developmental profile | - | Not reported | - | - | Stapley NW , et al. (2013) |
Emotion | - | Not reported | - | - | Stapley NW , et al. (2013) |
Immune response | - | Not reported | - | - | Stapley NW , et al. (2013) |
Learning & memory | Cued or contextual fear conditioning | Ameliorated | Fear conditioning test | 3-7 months | Stapley NW , et al. (2013) |
Learning & memory | Cued or contextual fear conditioning | Refractory | Fear conditioning test | 3-7 months | Stapley NW , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Molecular profile | - | Not reported | - | - | Stapley NW , et al. (2013) |
Motor phenotype | - | Not reported | - | - | Stapley NW , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Stapley NW , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Stapley NW , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Stapley NW , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Seizure | - | Not reported | - | - | Stapley NW , et al. (2013) |
Sensory | - | Not reported | - | - | Stapley NW , et al. (2013) |
Social behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
M_BTBR_1_INBRED_HM_BLASTOTRANS
Model Source:
JAX
Model Type:
RESCUE-Transplantation
Strain of Origin:
BTBR
Mutation:
BTBR embryos (3.5 dpc, BTBR) are transferred to the uterus of 2.5 dpc pseudopregnant recipient females (C57BL/6J)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Zhang Y , et al. (2013) |
Communications | - | Not reported | - | - | Zhang Y , et al. (2013) |
Developmental profile | - | Not reported | - | - | Zhang Y , et al. (2013) |
Emotion | - | Not reported | - | - | Zhang Y , et al. (2013) |
Immune response | Adaptive immune response: b cells antibody production: igg | Refractory | Elisa | 10 weeks | Zhang Y , et al. (2013) |
Learning & memory | - | Not reported | - | - | Zhang Y , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Zhang Y , et al. (2013) |
Molecular profile | - | Not reported | - | - | Zhang Y , et al. (2013) |
Motor phenotype | - | Not reported | - | - | Zhang Y , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Zhang Y , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Zhang Y , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Zhang Y , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Zhang Y , et al. (2013) |
Seizure | - | Not reported | - | - | Zhang Y , et al. (2013) |
Sensory | - | Not reported | - | - | Zhang Y , et al. (2013) |
Social behavior | Self grooming: social context | Ameliorated | Three-chamber social approach test | 10 weeks | Zhang Y , et al. (2013) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 10 weeks | Zhang Y , et al. (2013) |
M_BTBR_1_INBRED_HM_BUSPIRONE
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with buspirone (2 mg/kg) before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2010) |
Communications | - | Not reported | - | - | Gould GG , et al. (2010) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2010) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2010) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2010) |
Molecular profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Gould GG , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gould GG , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Gould GG , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2010) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | 3-4 months | Gould GG , et al. (2010) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2010) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2010) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
M_BTBR_1_INBRED_HM_CGS
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
10-week old adult male BTBR T+tf/J inbred mice were intraperitonealy injected with a single dose of 0.03mg/kg Adenosine A2A receptor agonist CGS 21680 for 7 days.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Ansari MA , et al. (2017) |
Communications | - | Not reported | - | - | Ansari MA , et al. (2017) |
Developmental profile | - | Not reported | - | - | Ansari MA , et al. (2017) |
Emotion | - | Not reported | - | - | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Restored | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Ameliorated | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Learning & memory | - | Not reported | - | - | Ansari MA , et al. (2017) |
Maternal behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Restored | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Ameliorated | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Restored | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Ameliorated | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein phosphorylation | Restored | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Motor phenotype | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neurophysiology | - | Not reported | - | - | Ansari MA , et al. (2017) |
Physiological parameters | - | Not reported | - | - | Ansari MA , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | Restored | Grooming behavior assessments | 11 weeks | Ansari MA , et al. (2017) |
Seizure | - | Not reported | - | - | Ansari MA , et al. (2017) |
Sensory | Pain or nociception | Ameliorated | Hot plate test | 11 weeks | Ansari MA , et al. (2017) |
Social behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
M_BTBR_1_INBRED_HM_CLOBAZAM
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were injected with 0.05 mg/kg clobazam (i.p.), a low dose of the drug
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | Anxiety | No adverse effect | Open field test | 6-10 months | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | - | Not reported | - | - | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | No adverse effect | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_CLONAZEPAM-1
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with 0.05 mg/kg, of Clonazepam 30 min before testing in each trial. This dose was tested to be NON-sedative. Lower doses than 0.05 were also tested and found to be less effective than the optimal dose of 0.05 mg/kg and are not indicated separately here
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | Anxiety | Restored | Open field test | 6-10 months | Han S , et al. (2014) |
Emotion | Anxiety | Ameliorated | Elevated plus maze test | 6-10 months | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Ameliorated | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context: short-term memory | Ameliorated | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Spatial reference memory | Restored | Barnes maze test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Spatial working memory | Restored | Barnes maze test | 6-10 months | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | Ameliorated | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | Circling | Ameliorated | Open field test | 6-10 months | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
Social behavior | Social approach | No sustained effect | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
Social behavior | Social interaction | Ameliorated | Reciprocal social interaction test | 6-10 months | Han S , et al. (2014) |
Social behavior | Social interaction | No sustained effect | Reciprocal social interaction test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_CLONAZEPAM-2
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with 0.075, or 0.1 mg/kg Clonazepam 30 min before testing in each trial (separate cohorts for doses). These were NON-sedative
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | - | Not reported | - | - | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Refractory | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context: short-term memory | Refractory | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social interaction | Refractory | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_CLONAZEPAM_3
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice are injected (i.p.) with Clonezapam at 0.05 mg/kg, every day for 14 days, 30 min before testing in trials. This dose and paradigm was NON-sedative to mice
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | - | Not reported | - | - | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Ameliorated | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | Ameliorated | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social interaction | Ameliorated | Reciprocal social interaction test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_COLEARNING
Model Source:
JAX
Model Type:
RESCUE-Behavioral
Strain of Origin:
BTBR
Mutation:
BTBR mice raised under social enrichment conditions (2 BTBR and 2 C57BL/6J mice) were through co-learning process with cagemates during the training phase of behavior tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Restored | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Side effect | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Refractory | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Communications | Ultrasonic vocalization | Side effect | Monitoring ultrasonic vocalizations | 12-14 weeks | Lipina TV and Roder JC (2012) |
Developmental profile | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Emotion | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Immune response | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Learning & memory | Cued or contextual fear conditioning | Ameliorated | Fear conditioning test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Learning & memory | Cued or contextual fear conditioning | Ameliorated | Fear conditioning test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Learning & memory | Object recognition memory | Restored | Object-place recognition test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Maternal behavior | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Molecular profile | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Motor phenotype | Hyperactivity | Restored | Elevated plus maze test | 12-14 weeks | Lipina TV and Roder JC (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Neurophysiology | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Physiological parameters | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Repetitive behavior | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Seizure | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Sensory | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
Social behavior | - | Not reported | - | - | Lipina TV and Roder JC (2012) |
M_BTBR_1_INBRED_HM_CX1739
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were p.o. administrated with CX1739 (3, 10, or 30 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Refractory | Grooming behavior assessments | 7 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6 weeks | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_CX1837
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were p.o. administrated with CX1837 (0.3, 1.0, or 3.0 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | Ultrasonic vocalization | Refractory | Monitoring ultrasonic vocalizations | 6-8 weeks | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | Ameliorated | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Emotion | Anxiety | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | Object recognition memory | Ameliorated | Novel object recognition test | 6-8 weeks | Silverman JL , et al. (2012) |
Learning & memory | Object recognition memory | Refractory | Novel object recognition test | 6-8 weeks | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Refractory | Grooming behavior assessments | 7 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6 weeks | Silverman JL , et al. (2012) |
Social behavior | Social interaction: opposite sex | Refractory | Reciprocal social interaction test | 6-8 weeks | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_CX546
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were p.o. or i.p. administrated with CX546 (25, 50, 75, or 100 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Ameliorated | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 8 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Refractory | Grooming behavior assessments | 7 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6 weeks | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_CX929
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with CX929 (5 mg/kg) twice daily for four days
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Seese RR , et al. (2014) |
Communications | - | Not reported | - | - | Seese RR , et al. (2014) |
Developmental profile | - | Not reported | - | - | Seese RR , et al. (2014) |
Emotion | - | Not reported | - | - | Seese RR , et al. (2014) |
Immune response | - | Not reported | - | - | Seese RR , et al. (2014) |
Learning & memory | Object recognition memory | Refractory | Object-place recognition test | 4-6 months | Seese RR , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
Molecular profile | - | Not reported | - | - | Seese RR , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Seese RR , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Seese RR , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Seese RR , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Seese RR , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
Seizure | - | Not reported | - | - | Seese RR , et al. (2014) |
Sensory | - | Not reported | - | - | Seese RR , et al. (2014) |
Social behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
M_BTBR_1_INBRED_HM_CYCLOSERINE
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR male mice were i.p. injected with D-cycloserine (320 mg/kg in saline)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Burket JA , et al. (2013) |
Communications | - | Not reported | - | - | Burket JA , et al. (2013) |
Developmental profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Emotion | - | Not reported | - | - | Burket JA , et al. (2013) |
Immune response | - | Not reported | - | - | Burket JA , et al. (2013) |
Learning & memory | - | Not reported | - | - | Burket JA , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Molecular profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Motor phenotype | General locomotor activity | Restored | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Burket JA , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Burket JA , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Burket JA , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Seizure | - | Not reported | - | - | Burket JA , et al. (2013) |
Sensory | - | Not reported | - | - | Burket JA , et al. (2013) |
Social behavior | Juvenile play | Refractory | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Rearing behavior | Refractory | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Self grooming: social context | Side effect | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social interaction | Ameliorated | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social withdrawal | Restored | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
M_BTBR_1_INBRED_HM_DIAZEPAM-1
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with diazepam (2.0 mg/kg in saline with 2% Tween-80) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Communications | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Developmental profile | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Emotion | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Immune response | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Learning & memory | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Molecular profile | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Repetitive behavior | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Seizure | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Sensory | - | Not reported | - | - | Pobbe RL , et al. (2010) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 14-17 weeks | Pobbe RL , et al. (2010) |
M_BTBR_1_INBRED_HM_DIAZEPAM-2
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with diazepam (2 mg/kg) 20 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Defensor EB , et al. (2010) |
Communications | - | Not reported | - | - | Defensor EB , et al. (2010) |
Developmental profile | - | Not reported | - | - | Defensor EB , et al. (2010) |
Emotion | Anxiety | Ameliorated | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Immune response | - | Not reported | - | - | Defensor EB , et al. (2010) |
Learning & memory | - | Not reported | - | - | Defensor EB , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Defensor EB , et al. (2010) |
Molecular profile | - | Not reported | - | - | Defensor EB , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Defensor EB , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Defensor EB , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Defensor EB , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Defensor EB , et al. (2010) |
Repetitive behavior | - | Not reported | - | - | Defensor EB , et al. (2010) |
Seizure | - | Not reported | - | - | Defensor EB , et al. (2010) |
Sensory | - | Not reported | - | - | Defensor EB , et al. (2010) |
Social behavior | Rearing behavior | Side effect | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Refractory | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Refractory | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Ameliorated | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social interaction | Refractory | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
Social behavior | Social withdrawal | Ameliorated | Reciprocal social interaction test | 12-14 weeks | Defensor EB , et al. (2010) |
M_BTBR_1_INBRED_HM_DIAZEPAM-3
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
Adult BTBR mice were treated with diazepam (20mg/kg in saline) or vehicle, daily, for 14 days (i.p.) between P45-P58
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gogolla N , et al. (2014) |
Communications | - | Not reported | - | - | Gogolla N , et al. (2014) |
Developmental profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Emotion | - | Not reported | - | - | Gogolla N , et al. (2014) |
Immune response | - | Not reported | - | - | Gogolla N , et al. (2014) |
Learning & memory | - | Not reported | - | - | Gogolla N , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Molecular profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Gogolla N , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gogolla N , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Gogolla N , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Gogolla N , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Seizure | - | Not reported | - | - | Gogolla N , et al. (2014) |
Sensory | Multisensory integration: sensory neurons of insular cortex: auditory-tactile | Refractory | Quantification of degree of integration | Adult | Gogolla N , et al. (2014) |
Sensory | Sensory-evoked response: excitation: auditory stimulus | Refractory | Measurement of area of activation (roi) in the insular cortex | Adult | Gogolla N , et al. (2014) |
Social behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
M_BTBR_1_INBRED_HM_DIAZEPAM-ADULT
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
Adult BTBR mice were acutely injected with 20mg/kg (in saline) of diazepam (i.p.) while the animal was undergoing intrinsic imaging experiment
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gogolla N , et al. (2014) |
Communications | - | Not reported | - | - | Gogolla N , et al. (2014) |
Developmental profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Emotion | - | Not reported | - | - | Gogolla N , et al. (2014) |
Immune response | - | Not reported | - | - | Gogolla N , et al. (2014) |
Learning & memory | - | Not reported | - | - | Gogolla N , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Molecular profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Gogolla N , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gogolla N , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Gogolla N , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Gogolla N , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Seizure | - | Not reported | - | - | Gogolla N , et al. (2014) |
Sensory | Multisensory integration: sensory neurons of insular cortex: auditory-tactile | Ameliorated | Quantification of degree of integration | Adult | Gogolla N , et al. (2014) |
Social behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
M_BTBR_1_INBRED_HM_DIAZEPAM-JUV
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
Juvenile BTBR mice were treated with diazepam (20mg/kg in saline) or vehicle (0.9% saline) , daily for 14 days (i.p.), between P15-P28
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gogolla N , et al. (2014) |
Communications | - | Not reported | - | - | Gogolla N , et al. (2014) |
Developmental profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Emotion | - | Not reported | - | - | Gogolla N , et al. (2014) |
Immune response | - | Not reported | - | - | Gogolla N , et al. (2014) |
Learning & memory | - | Not reported | - | - | Gogolla N , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Molecular profile | - | Not reported | - | - | Gogolla N , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Gogolla N , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Perineuronal net morphology | Ameliorated | Immunohistochemistry | 10-14 weeks | Gogolla N , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density: inhibitory | Ameliorated | Immunohistochemistry | 10-14 weeks | Gogolla N , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Synaptic morphology | Ameliorated | Immunohistochemistry | 10-14 weeks | Gogolla N , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Gogolla N , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Gogolla N , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
Seizure | - | Not reported | - | - | Gogolla N , et al. (2014) |
Sensory | Multisensory integration: sensory neurons of insular cortex: auditory-tactile | Restored | Quantification of degree of integration | 10-14 weeks | Gogolla N , et al. (2014) |
Sensory | Sensory-evoked response: excitation: auditory stimulus | Restored | Measurement of area of activation (roi) in the insular cortex | 10-14 weeks | Gogolla N , et al. (2014) |
Social behavior | - | Not reported | - | - | Gogolla N , et al. (2014) |
M_BTBR_1_INBRED_HM_DONEPEZIL-DMS
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were injected intracranially into dorsomedial-striatum (DMS) by a cannula implantation with artificial cerebrospinal fluid (aCSF) in the third running day for acclimation and with Donepezil (100 ng/ 0.5 l aCSF) in each day from the fourth day until the end of experiment
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Communications | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Developmental profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Emotion | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Immune response | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Learning & memory | Cognitive flexibility | Restored | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Object recognition memory | No adverse effect | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Procedural learning | No adverse effect | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Maternal behavior | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Molecular profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Motor phenotype | Self grooming: home cage/familiar environment | No adverse effect | Home cage behavior | 8 weeks | Karvat G and Kimchi T (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Neurophysiology | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Physiological parameters | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Repetitive behavior | Repetitive digging | No adverse effect | Home cage behavior | 8 weeks | Karvat G and Kimchi T (2013) |
Seizure | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Sensory | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Social behavior | Social interaction | Ameliorated | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
M_BTBR_1_INBRED_HM_DONEPEZIL-VMS
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were injected intracranially into ventromedial-striatum (VMS) by a cannula implantation with artificial cerebrospinal fluid (aCSF) in the third running day for acclimation and with Donepezil (100 ng/ 0.5 l aCSF) in each day from the fourth day until the end of experiment
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Communications | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Developmental profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Emotion | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Immune response | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Learning & memory | Cognitive flexibility | Refractory | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Object recognition memory | No adverse effect | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Procedural learning | No adverse effect | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Maternal behavior | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Molecular profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Motor phenotype | Self grooming: home cage/familiar environment | No adverse effect | Home cage behavior | 8 weeks | Karvat G and Kimchi T (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Neurophysiology | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Physiological parameters | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Repetitive behavior | Repetitive digging | No adverse effect | Home cage behavior | 8 weeks | Karvat G and Kimchi T (2013) |
Seizure | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Sensory | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Social behavior | Social interaction | Refractory | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
M_BTBR_1_INBRED_HM_DONEPEZIL_IP
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR male mice are injected i.p. with Donepezil (0.3 and 1.0 mg/kg) for 7 days
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Communications | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Developmental profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Emotion | Anxiety | No adverse effect | Open field test | 8 weeks | Karvat G and Kimchi T (2013) |
Immune response | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Learning & memory | Cognitive flexibility | Ameliorated | Water t-maze test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Cognitive flexibility | Restored | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Object recognition memory | No adverse effect | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Procedural learning | No adverse effect | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Spatial learning | No adverse effect | Water t-maze test | 8 weeks | Karvat G and Kimchi T (2013) |
Learning & memory | Spatial working memory | No adverse effect | Water t-maze test | 8 weeks | Karvat G and Kimchi T (2013) |
Maternal behavior | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Molecular profile | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Motor phenotype | General locomotor activity | No adverse effect | Open field test | 8 weeks | Karvat G and Kimchi T (2013) |
Motor phenotype | Self grooming: home cage/familiar environment | No adverse effect | Home cage behavior | 8 weeks | Karvat G and Kimchi T (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Neurophysiology | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Physiological parameters | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Repetitive behavior | Repetitive digging | No adverse effect | Home cage behavior | 8 weeks | Karvat G and Kimchi T (2013) |
Seizure | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Sensory | - | Not reported | - | - | Karvat G and Kimchi T (2013) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 8 weeks | Karvat G and Kimchi T (2013) |
Social behavior | Social interaction | Ameliorated | Reciprocal social interaction test | 8 weeks | Karvat G and Kimchi T (2013) |
Social behavior | Social interaction | Ameliorated | Running wheel test | 8 weeks | Karvat G and Kimchi T (2013) |
Social behavior | Social memory | Ameliorated | Three-chamber social approach test | 8 weeks | Karvat G and Kimchi T (2013) |
M_BTBR_1_INBRED_HM_FLUOXETINE-1-H
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with fluoxetine (30 mg/kg) 1 h before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Chadman KK (2010) |
Communications | - | Not reported | - | - | Chadman KK (2010) |
Developmental profile | - | Not reported | - | - | Chadman KK (2010) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Immune response | - | Not reported | - | - | Chadman KK (2010) |
Learning & memory | - | Not reported | - | - | Chadman KK (2010) |
Maternal behavior | - | Not reported | - | - | Chadman KK (2010) |
Molecular profile | - | Not reported | - | - | Chadman KK (2010) |
Motor phenotype | General locomotor activity | Side effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Motor phenotype | Hypoactivity | Side effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Chadman KK (2010) |
Neurophysiology | - | Not reported | - | - | Chadman KK (2010) |
Physiological parameters | - | Not reported | - | - | Chadman KK (2010) |
Repetitive behavior | - | Not reported | - | - | Chadman KK (2010) |
Seizure | - | Not reported | - | - | Chadman KK (2010) |
Sensory | - | Not reported | - | - | Chadman KK (2010) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
M_BTBR_1_INBRED_HM_FLUOXETINE-1-L
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with fluoxetine (10 mg/kg) 1 h before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Chadman KK (2010) |
Communications | - | Not reported | - | - | Chadman KK (2010) |
Developmental profile | - | Not reported | - | - | Chadman KK (2010) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Immune response | - | Not reported | - | - | Chadman KK (2010) |
Learning & memory | - | Not reported | - | - | Chadman KK (2010) |
Maternal behavior | - | Not reported | - | - | Chadman KK (2010) |
Molecular profile | - | Not reported | - | - | Chadman KK (2010) |
Motor phenotype | General locomotor activity | No adverse effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Motor phenotype | Hypoactivity | No adverse effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Chadman KK (2010) |
Neurophysiology | - | Not reported | - | - | Chadman KK (2010) |
Physiological parameters | - | Not reported | - | - | Chadman KK (2010) |
Repetitive behavior | - | Not reported | - | - | Chadman KK (2010) |
Seizure | - | Not reported | - | - | Chadman KK (2010) |
Sensory | - | Not reported | - | - | Chadman KK (2010) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Social behavior | Social memory | No adverse effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
M_BTBR_1_INBRED_HM_FLUOXETINE_2
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with fluoxetine (10 mg/kg) before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2010) |
Communications | - | Not reported | - | - | Gould GG , et al. (2010) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2010) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2010) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2010) |
Molecular profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Gould GG , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gould GG , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Gould GG , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2010) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | 3-4 months | Gould GG , et al. (2010) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2010) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2010) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
M_BTBR_1_INBRED_HM_FOSTERING_B
Model Source:
JAX
Model Type:
RESCUE-Behavioral
Strain of Origin:
BTBR
Mutation:
BTBR mice were cross-fostered by BTBR mothers within 24-h of parturition
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Yang M , et al. (2007) |
Communications | - | Not reported | - | - | Yang M , et al. (2007) |
Developmental profile | - | Not reported | - | - | Yang M , et al. (2007) |
Emotion | - | Not reported | - | - | Yang M , et al. (2007) |
Immune response | - | Not reported | - | - | Yang M , et al. (2007) |
Learning & memory | - | Not reported | - | - | Yang M , et al. (2007) |
Maternal behavior | - | Not reported | - | - | Yang M , et al. (2007) |
Molecular profile | - | Not reported | - | - | Yang M , et al. (2007) |
Motor phenotype | Self grooming: home cage/familiar environment | Refractory | Home cage behavior | Adult | Yang M , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Yang M , et al. (2007) |
Neurophysiology | - | Not reported | - | - | Yang M , et al. (2007) |
Physiological parameters | - | Not reported | - | - | Yang M , et al. (2007) |
Repetitive behavior | - | Not reported | - | - | Yang M , et al. (2007) |
Seizure | - | Not reported | - | - | Yang M , et al. (2007) |
Sensory | - | Not reported | - | - | Yang M , et al. (2007) |
Social behavior | Juvenile play | Ameliorated | Reciprocal social interaction test | 3 weeks | Yang M , et al. (2007) |
Social behavior | Juvenile play | Refractory | Reciprocal social interaction test | 3 weeks | Yang M , et al. (2007) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | Adult | Yang M , et al. (2007) |
M_BTBR_1_INBRED_HM_FOSTERING_C
Model Source:
JAX
Model Type:
RESCUE-Behavioral
Strain of Origin:
BTBR
Mutation:
BTBR mice were cross-fostered by C57BL/6J mothers within 24-h of parturition
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Yang M , et al. (2007) |
Communications | - | Not reported | - | - | Yang M , et al. (2007) |
Developmental profile | - | Not reported | - | - | Yang M , et al. (2007) |
Emotion | - | Not reported | - | - | Yang M , et al. (2007) |
Immune response | - | Not reported | - | - | Yang M , et al. (2007) |
Learning & memory | - | Not reported | - | - | Yang M , et al. (2007) |
Maternal behavior | - | Not reported | - | - | Yang M , et al. (2007) |
Molecular profile | - | Not reported | - | - | Yang M , et al. (2007) |
Motor phenotype | Self grooming: home cage/familiar environment | Refractory | Home cage behavior | Adult | Yang M , et al. (2007) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Yang M , et al. (2007) |
Neurophysiology | - | Not reported | - | - | Yang M , et al. (2007) |
Physiological parameters | - | Not reported | - | - | Yang M , et al. (2007) |
Repetitive behavior | - | Not reported | - | - | Yang M , et al. (2007) |
Seizure | - | Not reported | - | - | Yang M , et al. (2007) |
Sensory | - | Not reported | - | - | Yang M , et al. (2007) |
Social behavior | Juvenile play | Ameliorated | Reciprocal social interaction test | 3 weeks | Yang M , et al. (2007) |
Social behavior | Juvenile play | Refractory | Reciprocal social interaction test | 3 weeks | Yang M , et al. (2007) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | Adult | Yang M , et al. (2007) |
M_BTBR_1_INBRED_HM_GRN529
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with a single dose of GRN-529 ( 1.0, or 3.0 mg/kg in 10% Tween 80/saline)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | Anxiety | No adverse effect | Open field test | 9-10 weeks | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 9-10 weeks | Silverman JL , et al. (2012) |
Motor phenotype | General locomotor activity | No adverse effect | Open field test | 9-10 weeks | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Ameliorated | Home cage behavior | 9-10 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | Repetitive digging | Ameliorated | Three-chamber social approach test | 8-16 weeks | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | Self grooming: social context | Ameliorated | Three-chamber social approach test | 8-16 weeks | Silverman JL , et al. (2012) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 9-10 weeks | Silverman JL , et al. (2012) |
Social behavior | Social interaction | Ameliorated | Three-chamber social approach test | 8-16 weeks | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_KETO
Model Source:
JAX
Model Type:
RESCUE-Dietary
Strain of Origin:
BTBR
Mutation:
BTBR male mice are fed with ketogenic diet for 3-5 weeks
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Communications | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Developmental profile | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Emotion | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Immune response | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Learning & memory | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Molecular profile | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Motor phenotype | Self grooming: home cage/familiar environment | No adverse effect | Home cage behavior | 8-10 weeks | Ruskin DN , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Physiological parameters | Glucose levels | Side effect | In vitro diagnostic tests | 8-10 weeks | Ruskin DN , et al. (2013) |
Physiological parameters | Metabolite levels: ketone bodies | Side effect | In vitro diagnostic tests | 8-10 weeks | Ruskin DN , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Seizure | Seizure threshold | Refractory | Observation of electrically induced seizures | 8-10 weeks | Ruskin DN , et al. (2013) |
Sensory | - | Not reported | - | - | Ruskin DN , et al. (2013) |
Social behavior | Self grooming: social context | Ameliorated | Three-chamber social approach test | 8-10 weeks | Ruskin DN , et al. (2013) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 8-10 weeks | Ruskin DN , et al. (2013) |
Social behavior | Social interaction | Ameliorated | Three-chamber social approach test | 8-10 weeks | Ruskin DN , et al. (2013) |
Social behavior | Social memory | Refractory | Three-chamber social approach test | 8-10 weeks | Ruskin DN , et al. (2013) |
Social behavior | Social transmission of food preference | Ameliorated | Social transmission of food preference | 8-10 weeks | Ruskin DN , et al. (2013) |
M_BTBR_1_INBRED_HM_L838417-1
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with 0.025, 0.05 mg/kg of L838,417. 0.05 mg/kg was found to be the effective dose and the other lower doses are not indicated separately here
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | - | Not reported | - | - | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Ameliorated | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context: short-term memory | Ameliorated | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | No adverse effect | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_L838417-2
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with 0.5 mg/kg L838,417
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | - | Not reported | - | - | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | - | Not reported | - | - | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_LCPUFA
Model Source:
JAX
Model Type:
RESCUE-Dietary
Strain of Origin:
BTBR
Mutation:
BTBR mice is treated with LCPUFA dietary, that contains low-glycemic index carbohydrates, dietary fibers, high trypthophan content and a lipid profile that predominantly differed in DHA and EPA content (omega-3 long-chain polyunsaturated fatty acids, for 7 consecutive weeks before testing
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Wu J , et al. (2016) |
Communications | - | Not reported | - | - | Wu J , et al. (2016) |
Developmental profile | - | Not reported | - | - | Wu J , et al. (2016) |
Emotion | - | Not reported | - | - | Wu J , et al. (2016) |
Immune response | - | Not reported | - | - | Wu J , et al. (2016) |
Learning & memory | - | Not reported | - | - | Wu J , et al. (2016) |
Maternal behavior | - | Not reported | - | - | Wu J , et al. (2016) |
Molecular profile | Protein phosphorylation | No adverse effect | Western blot | 12 weeks | Wu J , et al. (2016) |
Molecular profile | Signaling: mtor | No adverse effect | Western blot | 12 weeks | Wu J , et al. (2016) |
Molecular profile | Signaling: mtor | Refractory | Western blot | 12 weeks | Wu J , et al. (2016) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 12 weeks | Wu J , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Wu J , et al. (2016) |
Neurophysiology | - | Not reported | - | - | Wu J , et al. (2016) |
Physiological parameters | - | Not reported | - | - | Wu J , et al. (2016) |
Repetitive behavior | Self grooming: perseveration | Refractory | Grooming behavior assessments | 12 weeks | Wu J , et al. (2016) |
Seizure | - | Not reported | - | - | Wu J , et al. (2016) |
Sensory | - | Not reported | - | - | Wu J , et al. (2016) |
Social behavior | Social interaction | Refractory | Partition test | 12 weeks | Wu J , et al. (2016) |
M_BTBR_1_INBRED_HM_M100907_1_H
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with M100907 (0.1 mg/kg) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Communications | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Developmental profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Emotion | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Immune response | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Restored | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Restored | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Spatial learning | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Molecular profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Repetitive behavior | Perseveration | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Seizure | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Sensory | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Social behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
M_BTBR_1_INBRED_HM_M100907_1_L
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with M100907 (0.01 mg/kg) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Communications | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Developmental profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Emotion | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Immune response | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Restored | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Refractory | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Spatial learning | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Molecular profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Repetitive behavior | Perseveration | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Seizure | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Sensory | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Social behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
M_BTBR_1_INBRED_HM_MDMA
Model Source:
Not Specified
Model Type:
Pharmaceutical intervention
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MDMA (20 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Communications | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Developmental profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Emotion | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Immune response | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Learning & memory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Maternal behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Molecular profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Motor phenotype | General locomotor activity | No change | Running wheel test | Adult | Onaivi ES , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: catecholamines | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: serotonin | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Physiological parameters | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Repetitive behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Seizure | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Sensory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Social behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
M_BTBR_1_INBRED_HM_METH
Model Source:
Not Specified
Model Type:
Pharmaceutical intervention
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with methamphetamine (10 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Communications | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Developmental profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Emotion | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Immune response | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Learning & memory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Maternal behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Molecular profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Motor phenotype | General locomotor activity | No change | Running wheel test | Adult | Onaivi ES , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: catecholamines | Decreased | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: catecholamines | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: serotonin | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Physiological parameters | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Repetitive behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Seizure | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Sensory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Social behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
M_BTBR_1_INBRED_HM_MPEP_1
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPEP (5 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Seese RR , et al. (2014) |
Communications | - | Not reported | - | - | Seese RR , et al. (2014) |
Developmental profile | - | Not reported | - | - | Seese RR , et al. (2014) |
Emotion | - | Not reported | - | - | Seese RR , et al. (2014) |
Immune response | - | Not reported | - | - | Seese RR , et al. (2014) |
Learning & memory | Object recognition memory | Restored | Object-place recognition test | 4-6 months | Seese RR , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
Molecular profile | Signaling | Ameliorated | Fluorescence tomography | 4-6 months | Seese RR , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Seese RR , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Seese RR , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Seese RR , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Seese RR , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
Seizure | - | Not reported | - | - | Seese RR , et al. (2014) |
Sensory | - | Not reported | - | - | Seese RR , et al. (2014) |
Social behavior | - | Not reported | - | - | Seese RR , et al. (2014) |
M_BTBR_1_INBRED_HM_MPEP_2
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPEP (10 mg/kg in saline)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Ameliorated | Home cage behavior | 9-10 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_MPEP_3
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPEP (0.50 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Refractory | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_MPEP_4
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPEP (1.0 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Restored | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_MPEP_5
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPEP (10 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Restored | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_MPEP_6
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPEP (30 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Restored | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_MPTP
Model Source:
Not Specified
Model Type:
Pharmaceutical intervention
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MPTP (20 mg/kg)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Communications | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Developmental profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Emotion | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Immune response | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Learning & memory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Maternal behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Molecular profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Motor phenotype | General locomotor activity | Increased | Running wheel test | Adult | Onaivi ES , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: catecholamines | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Neurophysiology | Neurotransmitter release: serotonin | No change | High-performance liquid chromatography (hplc) | Adult | Onaivi ES , et al. (2011) |
Physiological parameters | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Repetitive behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Seizure | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Sensory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Social behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
M_BTBR_1_INBRED_HM_MTEP
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with MTEP (0.3, 0.6, 1.0 or 3.0 mg/kg in saline)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2012) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2012) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2012) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2012) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2012) |
Motor phenotype | Self grooming: home cage/familiar environment | Restored | Home cage behavior | 9-10 weeks | Silverman JL , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2012) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2012) |
Social behavior | - | Not reported | - | - | Silverman JL , et al. (2012) |
M_BTBR_1_INBRED_HM_MTOR-DIET
Model Source:
JAX
Model Type:
RESCUE-Dietary
Strain of Origin:
BTBR
Mutation:
BTBR mice is treated with the mTOR-targeting amino acid dietary, that aimed to attenuate the mTOR signaling pathway, for 7 consecutive weeks before testing
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Wu J , et al. (2016) |
Communications | - | Not reported | - | - | Wu J , et al. (2016) |
Developmental profile | - | Not reported | - | - | Wu J , et al. (2016) |
Emotion | - | Not reported | - | - | Wu J , et al. (2016) |
Immune response | - | Not reported | - | - | Wu J , et al. (2016) |
Learning & memory | - | Not reported | - | - | Wu J , et al. (2016) |
Maternal behavior | - | Not reported | - | - | Wu J , et al. (2016) |
Molecular profile | Protein phosphorylation | No adverse effect | Western blot | 12 weeks | Wu J , et al. (2016) |
Molecular profile | Signaling: mtor | No adverse effect | Western blot | 12 weeks | Wu J , et al. (2016) |
Molecular profile | Signaling: mtor | Restored | Western blot | 12 weeks | Wu J , et al. (2016) |
Motor phenotype | General locomotor activity | Refractory | Open field test | 12 weeks | Wu J , et al. (2016) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Wu J , et al. (2016) |
Neurophysiology | - | Not reported | - | - | Wu J , et al. (2016) |
Physiological parameters | - | Not reported | - | - | Wu J , et al. (2016) |
Repetitive behavior | Self grooming: perseveration | Restored | Grooming behavior assessments | 12 weeks | Wu J , et al. (2016) |
Seizure | - | Not reported | - | - | Wu J , et al. (2016) |
Sensory | - | Not reported | - | - | Wu J , et al. (2016) |
Social behavior | Social interaction | Refractory | Partition test | 12 weeks | Wu J , et al. (2016) |
M_BTBR_1_INBRED_HM_PEER-INTERACT
Model Source:
JAX
Model Type:
RESCUE-Behavioral
Strain of Origin:
BTBR
Mutation:
Weaned BTBR mice lived with C57BL/6J cagemates 40 or 60 days before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Yang M , et al. (2010) |
Communications | - | Not reported | - | - | Yang M , et al. (2010) |
Developmental profile | - | Not reported | - | - | Yang M , et al. (2010) |
Emotion | - | Not reported | - | - | Yang M , et al. (2010) |
Immune response | - | Not reported | - | - | Yang M , et al. (2010) |
Learning & memory | - | Not reported | - | - | Yang M , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Yang M , et al. (2010) |
Molecular profile | - | Not reported | - | - | Yang M , et al. (2010) |
Motor phenotype | General locomotor activity | No adverse effect | Three-chamber social approach test | 6-8 weeks | Yang M , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Yang M , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Yang M , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Yang M , et al. (2010) |
Repetitive behavior | Self grooming: perseveration | Refractory | Grooming behavior assessments | 6-8 weeks | Yang M , et al. (2010) |
Seizure | - | Not reported | - | - | Yang M , et al. (2010) |
Sensory | - | Not reported | - | - | Yang M , et al. (2010) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 6-8 weeks | Yang M , et al. (2010) |
M_BTBR_1_INBRED_HM_PSD95-GFP
Model Source:
JAX
Model Type:
Genetic
Strain of Origin:
BTBR
Mutation:
The progenitor cells for layer 2/3 neurons in the somatosensory cortex and anterior frontal cortex of BTBR were transfected using in utero electroporation. E15.5 timed pregnant mice were deeply anaesthetized, their uterine horns were exposed and approximately 1ul of DNA mixture, containing DsRed2 plasmid (1ug/ul) and PSD-95-GFP plasmid (1-2ug/ul), was pressure injected into the lateral ventricle of each embryo through a micropipette. Electric pulses were passed through the head of each embryo using two tweezer type electrodes for electroporation.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Isshiki M , et al. (2014) |
Communications | - | Not reported | - | - | Isshiki M , et al. (2014) |
Developmental profile | - | Not reported | - | - | Isshiki M , et al. (2014) |
Emotion | - | Not reported | - | - | Isshiki M , et al. (2014) |
Immune response | - | Not reported | - | - | Isshiki M , et al. (2014) |
Learning & memory | - | Not reported | - | - | Isshiki M , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Isshiki M , et al. (2014) |
Molecular profile | - | Not reported | - | - | Isshiki M , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine turnover | Increased | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine turnover | No change | Two-photon microscopy | 3 weeks | Isshiki M , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Isshiki M , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Isshiki M , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Isshiki M , et al. (2014) |
Seizure | - | Not reported | - | - | Isshiki M , et al. (2014) |
Sensory | - | Not reported | - | - | Isshiki M , et al. (2014) |
Social behavior | - | Not reported | - | - | Isshiki M , et al. (2014) |
M_BTBR_1_INBRED_HM_RAPAMYCIN
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with rapamycin (10 mg/kg) in a volume of 0.01 ml/g on four consecutive days
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Burket JA , et al. (2013) |
Communications | - | Not reported | - | - | Burket JA , et al. (2013) |
Developmental profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Emotion | - | Not reported | - | - | Burket JA , et al. (2013) |
Immune response | - | Not reported | - | - | Burket JA , et al. (2013) |
Learning & memory | - | Not reported | - | - | Burket JA , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Molecular profile | - | Not reported | - | - | Burket JA , et al. (2013) |
Motor phenotype | General locomotor activity | Refractory | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Burket JA , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Burket JA , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Burket JA , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Burket JA , et al. (2013) |
Seizure | - | Not reported | - | - | Burket JA , et al. (2013) |
Sensory | - | Not reported | - | - | Burket JA , et al. (2013) |
Social behavior | Juvenile play | No adverse effect | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Rearing behavior | Refractory | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Self grooming: social context | No adverse effect | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social interaction | Ameliorated | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
Social behavior | Social withdrawal | No adverse effect | Three-chamber social approach test | 4 weeks | Burket JA , et al. (2013) |
M_BTBR_1_INBRED_HM_RISPERIDONE-1-H
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.5 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Side effect | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_RISPERIDONE-1-L
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.125 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Restored | Open field test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | No adverse effect | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Ameliorated | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_RISPERIDONE-1-M
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.25 mg/kg in saline) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Silverman JL , et al. (2009) |
Communications | - | Not reported | - | - | Silverman JL , et al. (2009) |
Developmental profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Emotion | - | Not reported | - | - | Silverman JL , et al. (2009) |
Immune response | - | Not reported | - | - | Silverman JL , et al. (2009) |
Learning & memory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Maternal behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Molecular profile | - | Not reported | - | - | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | General locomotor activity | Side effect | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
Motor phenotype | Self grooming: home cage/familiar environment | Ameliorated | Grooming behavior assessments | 6-8 weeks | Silverman JL , et al. (2009) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Silverman JL , et al. (2009) |
Neurophysiology | - | Not reported | - | - | Silverman JL , et al. (2009) |
Physiological parameters | - | Not reported | - | - | Silverman JL , et al. (2009) |
Repetitive behavior | - | Not reported | - | - | Silverman JL , et al. (2009) |
Seizure | - | Not reported | - | - | Silverman JL , et al. (2009) |
Sensory | - | Not reported | - | - | Silverman JL , et al. (2009) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-8 weeks | Silverman JL , et al. (2009) |
M_BTBR_1_INBRED_HM_RISPERIDONE-2-H
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.3 mg/kg) 1 h before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Chadman KK (2010) |
Communications | - | Not reported | - | - | Chadman KK (2010) |
Developmental profile | - | Not reported | - | - | Chadman KK (2010) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Immune response | - | Not reported | - | - | Chadman KK (2010) |
Learning & memory | - | Not reported | - | - | Chadman KK (2010) |
Maternal behavior | - | Not reported | - | - | Chadman KK (2010) |
Molecular profile | - | Not reported | - | - | Chadman KK (2010) |
Motor phenotype | General locomotor activity | Side effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Motor phenotype | Hypoactivity | Side effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Chadman KK (2010) |
Neurophysiology | - | Not reported | - | - | Chadman KK (2010) |
Physiological parameters | - | Not reported | - | - | Chadman KK (2010) |
Repetitive behavior | - | Not reported | - | - | Chadman KK (2010) |
Seizure | - | Not reported | - | - | Chadman KK (2010) |
Sensory | - | Not reported | - | - | Chadman KK (2010) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
M_BTBR_1_INBRED_HM_RISPERIDONE-3
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.1 mg/kg) before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2010) |
Communications | - | Not reported | - | - | Gould GG , et al. (2010) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2010) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2010) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2010) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2010) |
Molecular profile | - | Not reported | - | - | Gould GG , et al. (2010) |
Motor phenotype | - | Not reported | - | - | Gould GG , et al. (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gould GG , et al. (2010) |
Neurophysiology | - | Not reported | - | - | Gould GG , et al. (2010) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2010) |
Repetitive behavior | Repetitive digging | Ameliorated | Marble-burying test | 3-4 months | Gould GG , et al. (2010) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2010) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2010) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2010) |
M_BTBR_1_INBRED_HM_RISPERIDONE-4-H
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.125 mg/kg) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Communications | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Developmental profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Emotion | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Immune response | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Restored | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Restored | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Spatial learning | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Molecular profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Repetitive behavior | Perseveration | No adverse effect | Spatial discrimination assay | Unreported | Amodeo DA , et al. (2014) |
Seizure | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Sensory | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Social behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
M_BTBR_1_INBRED_HM_RISPERIDONE-4-L
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.0125 mg/kg) 30 min before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Communications | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Developmental profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Emotion | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Immune response | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Learning & memory | Cognitive flexibility | Refractory | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Learning & memory | Spatial learning | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Molecular profile | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Repetitive behavior | Perseveration | No adverse effect | Spatial discrimination assay | 8 weeks | Amodeo DA , et al. (2014) |
Seizure | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Sensory | - | Not reported | - | - | Amodeo DA , et al. (2014) |
Social behavior | - | Not reported | - | - | Amodeo DA , et al. (2014) |
M_BTBR_1_INBRED_HM_RISPERIDONE_2_L
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with risperidone (0.03 mg/kg) 1 h before tests
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Chadman KK (2010) |
Communications | - | Not reported | - | - | Chadman KK (2010) |
Developmental profile | - | Not reported | - | - | Chadman KK (2010) |
Emotion | Anxiety | No adverse effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Immune response | - | Not reported | - | - | Chadman KK (2010) |
Learning & memory | - | Not reported | - | - | Chadman KK (2010) |
Maternal behavior | - | Not reported | - | - | Chadman KK (2010) |
Molecular profile | - | Not reported | - | - | Chadman KK (2010) |
Motor phenotype | General locomotor activity | No adverse effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Motor phenotype | Hypoactivity | No adverse effect | Elevated plus maze test | 8-15 weeks | Chadman KK (2010) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Chadman KK (2010) |
Neurophysiology | - | Not reported | - | - | Chadman KK (2010) |
Physiological parameters | - | Not reported | - | - | Chadman KK (2010) |
Repetitive behavior | - | Not reported | - | - | Chadman KK (2010) |
Seizure | - | Not reported | - | - | Chadman KK (2010) |
Sensory | - | Not reported | - | - | Chadman KK (2010) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 8-15 weeks | Chadman KK (2010) |
M_BTBR_1_INBRED_HM_SCH
Model Source:
JAX
Model Type:
Pharmaceutical intervention
Strain of Origin:
BTBR
Mutation:
10-week old adult male BTBR T+tf/J inbred mice were intraperitonealy injected with a single dose of 0.03mg/kg Adenosine A2A receptor antagonist SCH 5826 for 7 days. C57BL/6 mice were used as controls.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Ansari MA , et al. (2017) |
Communications | - | Not reported | - | - | Ansari MA , et al. (2017) |
Developmental profile | - | Not reported | - | - | Ansari MA , et al. (2017) |
Emotion | - | Not reported | - | - | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Decreased | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Increased | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Learning & memory | - | Not reported | - | - | Ansari MA , et al. (2017) |
Maternal behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Decreased | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Increased | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Decreased | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Increased | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein phosphorylation | Increased | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Motor phenotype | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neurophysiology | - | Not reported | - | - | Ansari MA , et al. (2017) |
Physiological parameters | - | Not reported | - | - | Ansari MA , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 11 weeks | Ansari MA , et al. (2017) |
Seizure | - | Not reported | - | - | Ansari MA , et al. (2017) |
Sensory | Pain or nociception | Decreased | Hot plate test | 11 weeks | Ansari MA , et al. (2017) |
Social behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
M_BTBR_1_INBRED_HM_SCH_CGS
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
10-week old adult male BTBR T+tf/J inbred mice were intraperitonealy injected with a single dose of 0.03mg/kg Adenosine A2A receptor agonist CGS 21680 and 0.03mg/kg Adenosine A2A receptor antagonist SCH 5826 for 7 days.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Ansari MA , et al. (2017) |
Communications | - | Not reported | - | - | Ansari MA , et al. (2017) |
Developmental profile | - | Not reported | - | - | Ansari MA , et al. (2017) |
Emotion | - | Not reported | - | - | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Restored | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Immune response | Adaptive immune response: t cells | Ameliorated | Flow cytometric analysis | 11 weeks | Ansari MA , et al. (2017) |
Learning & memory | - | Not reported | - | - | Ansari MA , et al. (2017) |
Maternal behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Restored | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Gene expression | Ameliorated | Quantitative pcr (qrt-pcr) | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Restored | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein expression level evidence | Ameliorated | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Molecular profile | Protein phosphorylation | Ameliorated | Western blot | 11 weeks | Ansari MA , et al. (2017) |
Motor phenotype | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Ansari MA , et al. (2017) |
Neurophysiology | - | Not reported | - | - | Ansari MA , et al. (2017) |
Physiological parameters | - | Not reported | - | - | Ansari MA , et al. (2017) |
Repetitive behavior | Self grooming: perseveration | Restored | Grooming behavior assessments | 11 weeks | Ansari MA , et al. (2017) |
Seizure | - | Not reported | - | - | Ansari MA , et al. (2017) |
Sensory | Pain or nociception | Ameliorated | Hot plate test | 11 weeks | Ansari MA , et al. (2017) |
Social behavior | - | Not reported | - | - | Ansari MA , et al. (2017) |
M_BTBR_1_INBRED_HM_THC
Model Source:
Not Specified
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with Delta9-THC (1.0 or 10.0 mg/kg) 10 min before testing
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Communications | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Developmental profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Emotion | Depression | Refractory | Forced swim test | Adult | Onaivi ES , et al. (2011) |
Immune response | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Learning & memory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Maternal behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Molecular profile | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Motor phenotype | General locomotor activity | Ameliorated | Running wheel test | Adult | Onaivi ES , et al. (2011) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Neurophysiology | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Physiological parameters | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Repetitive behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Seizure | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Sensory | - | Not reported | - | - | Onaivi ES , et al. (2011) |
Social behavior | - | Not reported | - | - | Onaivi ES , et al. (2011) |
M_BTBR_1_INBRED_HM_TO901317
Model Source:
Model Animal Research Center of Nanjing University (Nanjing, China)
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
2% TO901317 dissolved in DMSO was intraperitoneally injected into male pups at a dose of 50mg/kg on P5, P7, P9. P11 and P13 every 2 days and tests conducted at 8 weeks. Vehicle injected C57Bl6 mice were used as controls.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Cai Y , et al. (2019) |
Communications | - | Not reported | - | - | Cai Y , et al. (2019) |
Developmental profile | - | Not reported | - | - | Cai Y , et al. (2019) |
Emotion | - | Not reported | - | - | Cai Y , et al. (2019) |
Immune response | - | Not reported | - | - | Cai Y , et al. (2019) |
Learning & memory | - | Not reported | - | - | Cai Y , et al. (2019) |
Maternal behavior | - | Not reported | - | - | Cai Y , et al. (2019) |
Molecular profile | Gene expression | No adverse effect | Quantitative pcr (qrt-pcr) | P15 | Cai Y , et al. (2019) |
Molecular profile | Gene expression | Side effect | Quantitative pcr (qrt-pcr) | P15 | Cai Y , et al. (2019) |
Motor phenotype | - | Not reported | - | - | Cai Y , et al. (2019) |
Neuroanatomy / Ultrastructure / Cytoarchitecture | Cell proliferation: neural precursors | Ameliorated | Immunohistochemistry | Adult | Cai Y , et al. (2019) |
Neurophysiology | - | Not reported | - | - | Cai Y , et al. (2019) |
Physiological parameters | - | Not reported | - | - | Cai Y , et al. (2019) |
Repetitive behavior | Self grooming: perseveration | Ameliorated | Grooming behavior assessments | 8 weeks | Cai Y , et al. (2019) |
Seizure | - | Not reported | - | - | Cai Y , et al. (2019) |
Sensory | - | Not reported | - | - | Cai Y , et al. (2019) |
Social behavior | Rearing behavior | No adverse effect | Novel cage test | 8 weeks | Cai Y , et al. (2019) |
Social behavior | Social approach | Restored | Three-chamber social approach test | 8 weeks | Cai Y , et al. (2019) |
M_BTBR_1_INBRED_HM_TRAINING
Model Source:
JAX
Model Type:
RESCUE-Behavioral
Strain of Origin:
BTBR
Mutation:
BTBR male mice with different numbers of repeats of CS (conditional stimulus: white noise for 30 s at 80 dB) - US (unconditional stimulus: a footshock) pairings (1, 4, or 10) during the training phase
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Stapley NW , et al. (2013) |
Communications | - | Not reported | - | - | Stapley NW , et al. (2013) |
Developmental profile | - | Not reported | - | - | Stapley NW , et al. (2013) |
Emotion | - | Not reported | - | - | Stapley NW , et al. (2013) |
Immune response | - | Not reported | - | - | Stapley NW , et al. (2013) |
Learning & memory | Cued or contextual fear conditioning | Ameliorated | Fear conditioning test | 3-7 months | Stapley NW , et al. (2013) |
Learning & memory | Cued or contextual fear conditioning | Restored | Fear conditioning test | 3-7 months | Stapley NW , et al. (2013) |
Maternal behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Molecular profile | - | Not reported | - | - | Stapley NW , et al. (2013) |
Motor phenotype | - | Not reported | - | - | Stapley NW , et al. (2013) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Stapley NW , et al. (2013) |
Neurophysiology | - | Not reported | - | - | Stapley NW , et al. (2013) |
Physiological parameters | - | Not reported | - | - | Stapley NW , et al. (2013) |
Repetitive behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
Seizure | - | Not reported | - | - | Stapley NW , et al. (2013) |
Sensory | - | Not reported | - | - | Stapley NW , et al. (2013) |
Social behavior | - | Not reported | - | - | Stapley NW , et al. (2013) |
M_BTBR_1_INBRED_HM_WIN55212
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with (0.1 mg/kg in saline with 10% DMSO)
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Gould GG , et al. (2012) |
Communications | - | Not reported | - | - | Gould GG , et al. (2012) |
Developmental profile | - | Not reported | - | - | Gould GG , et al. (2012) |
Emotion | - | Not reported | - | - | Gould GG , et al. (2012) |
Immune response | - | Not reported | - | - | Gould GG , et al. (2012) |
Learning & memory | - | Not reported | - | - | Gould GG , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Gould GG , et al. (2012) |
Molecular profile | - | Not reported | - | - | Gould GG , et al. (2012) |
Motor phenotype | General locomotor activity | Side effect | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Gould GG , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Gould GG , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Gould GG , et al. (2012) |
Repetitive behavior | Repetitive digging | Refractory | Marble-burying test | 3-4 months | Gould GG , et al. (2012) |
Seizure | - | Not reported | - | - | Gould GG , et al. (2012) |
Sensory | - | Not reported | - | - | Gould GG , et al. (2012) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
Social behavior | Social memory | Side effect | Three-chamber social approach test | 3-4 months | Gould GG , et al. (2012) |
M_BTBR_1_INBRED_HM_ZOLPIDEM-1
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with 0.05 mg/kg Zolpidem. Lower doses of 0.025 were also tested but most results are on 0.05mg/kg of zolpidem injection only
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | - | Not reported | - | - | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | - | Not reported | - | - | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | General locomotor activity | Side effect | Open field test | 6-10 months | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Side effect | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
M_BTBR_1_INBRED_HM_ZOLPIDEM-2
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
BTBR mice were i.p. injected with 0.5 mg/kg Zolpidem
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Han S , et al. (2014) |
Communications | - | Not reported | - | - | Han S , et al. (2014) |
Developmental profile | - | Not reported | - | - | Han S , et al. (2014) |
Emotion | - | Not reported | - | - | Han S , et al. (2014) |
Immune response | - | Not reported | - | - | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context | Refractory | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Learning & memory | Cued or contextual fear conditioning: memory of context: short-term memory | Ameliorated | Fear conditioning test | 6-10 months | Han S , et al. (2014) |
Maternal behavior | - | Not reported | - | - | Han S , et al. (2014) |
Molecular profile | - | Not reported | - | - | Han S , et al. (2014) |
Motor phenotype | - | Not reported | - | - | Han S , et al. (2014) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Han S , et al. (2014) |
Neurophysiology | - | Not reported | - | - | Han S , et al. (2014) |
Physiological parameters | - | Not reported | - | - | Han S , et al. (2014) |
Repetitive behavior | - | Not reported | - | - | Han S , et al. (2014) |
Seizure | - | Not reported | - | - | Han S , et al. (2014) |
Sensory | - | Not reported | - | - | Han S , et al. (2014) |
Social behavior | Social approach | Refractory | Three-chamber social approach test | 6-10 months | Han S , et al. (2014) |
M_BTBR_2_INBRED_HT
Model Source:
JAX
Model Type:
Inbred
Strain of Origin:
BTBR/C57BL/6J
Mutation:
The F1 offsprings of BTBR male and C57BL/6J female mice
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Zhang Y , et al. (2012) |
Communications | - | Not reported | - | - | Zhang Y , et al. (2012) |
Developmental profile | - | Not reported | - | - | Zhang Y , et al. (2012) |
Emotion | - | Not reported | - | - | Zhang Y , et al. (2012) |
Immune response | - | Not reported | - | - | Zhang Y , et al. (2012) |
Learning & memory | - | Not reported | - | - | Zhang Y , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Zhang Y , et al. (2012) |
Molecular profile | - | Not reported | - | - | Zhang Y , et al. (2012) |
Motor phenotype | - | Not reported | - | - | Zhang Y , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Zhang Y , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Zhang Y , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Zhang Y , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Zhang Y , et al. (2012) |
Seizure | - | Not reported | - | - | Zhang Y , et al. (2012) |
Sensory | - | Not reported | - | - | Zhang Y , et al. (2012) |
Social behavior | - | Not reported | - | - | Zhang Y , et al. (2012) |
M_BTBR_2_INBRED_HT_HG
Model Source:
JAX
Model Type:
Pharmaceutical intervention
Strain of Origin:
BTBR/C57BL/6J
Mutation:
The F1 offsprings of BTBR male and C57BL/6J female mice were exposed to HgCl2 by providing the their mothers with 50 micromolar HgCl2 drinking water from gd8 to pnd21
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Zhang Y , et al. (2012) |
Communications | - | Not reported | - | - | Zhang Y , et al. (2012) |
Developmental profile | - | Not reported | - | - | Zhang Y , et al. (2012) |
Emotion | - | Not reported | - | - | Zhang Y , et al. (2012) |
Immune response | Adaptive immune response: b cells antibody production: igg | Increased | Elisa | 3, 10 weeks | Zhang Y , et al. (2012) |
Immune response | Adaptive immune response: b cells antibody production: igg | Increased | Elisa | 3, 10 weeks | Zhang Y , et al. (2012) |
Immune response | Adaptive immune response: b cells antibody production: igg | No change | Elisa | 3, 10 weeks | Zhang Y , et al. (2012) |
Immune response | Cytokine levels | No change | Bead-based multiplex assay | 3, 10 weeks | Zhang Y , et al. (2012) |
Learning & memory | - | Not reported | - | - | Zhang Y , et al. (2012) |
Maternal behavior | - | Not reported | - | - | Zhang Y , et al. (2012) |
Molecular profile | - | Not reported | - | - | Zhang Y , et al. (2012) |
Motor phenotype | - | Not reported | - | - | Zhang Y , et al. (2012) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Zhang Y , et al. (2012) |
Neurophysiology | - | Not reported | - | - | Zhang Y , et al. (2012) |
Physiological parameters | - | Not reported | - | - | Zhang Y , et al. (2012) |
Repetitive behavior | - | Not reported | - | - | Zhang Y , et al. (2012) |
Seizure | - | Not reported | - | - | Zhang Y , et al. (2012) |
Sensory | - | Not reported | - | - | Zhang Y , et al. (2012) |
Social behavior | Self grooming: social context | No change | Three-chamber social approach test | 10 weeks | Zhang Y , et al. (2012) |
Social behavior | Social approach | No adverse effect | Three-chamber social approach test | 10 weeks | Zhang Y , et al. (2012) |
M_BTBR_3_INBRED_HM
Model Source:
JAX
Model Type:
Inbred
Strain of Origin:
BTBR
Mutation:
BTBR T+ Itpr3^tf-Fbxl3^Ovtm/J mice (Jax, cat # 016926) also known as BTBR overtime harbor the ENU induced mutation Fbxl3^Ovtm (F-box and leucine-rich repeat protein 3) on the BTBR inbred background resulting in an extended ciracadian period.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Sgritta M , et al. (2018) |
Communications | - | Not reported | - | - | Sgritta M , et al. (2018) |
Developmental profile | - | Not reported | - | - | Sgritta M , et al. (2018) |
Emotion | - | Not reported | - | - | Sgritta M , et al. (2018) |
Immune response | - | Not reported | - | - | Sgritta M , et al. (2018) |
Learning & memory | - | Not reported | - | - | Sgritta M , et al. (2018) |
Maternal behavior | - | Not reported | - | - | Sgritta M , et al. (2018) |
Molecular profile | - | Not reported | - | - | Sgritta M , et al. (2018) |
Motor phenotype | - | Not reported | - | - | Sgritta M , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Sgritta M , et al. (2018) |
Neurophysiology | - | Not reported | - | - | Sgritta M , et al. (2018) |
Physiological parameters | - | Not reported | - | - | Sgritta M , et al. (2018) |
Physiological parameters | Intestinal microbiota composition: overall microbiota composition | Abnormal | 16s rrna gene sequence analysis for identification of bacteria | 7-10 weeks | Sgritta M , et al. (2018) |
Physiological parameters | Intestinal microbiota composition: species diversity | Decreased | Quantitative pcr (qrt-pcr) | 7-10 weeks | Sgritta M , et al. (2018) |
Physiological parameters | Intestinal microbiota composition: species diversity | Decreased | 16s rrna gene sequence analysis for identification of bacteria | 7-10 weeks | Sgritta M , et al. (2018) |
Repetitive behavior | - | Not reported | - | - | Sgritta M , et al. (2018) |
Seizure | - | Not reported | - | - | Sgritta M , et al. (2018) |
Sensory | Olfaction | No change | Buried food test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social approach | Decreased | Three-chamber social approach test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social memory | Decreased | Three-chamber social approach test | 7-10 weeks | Sgritta M , et al. (2018) |
M_BTBR_3_INBRED_HM_LREUTERI
Model Source:
JAX
Model Type:
RESCUE-Dietary
Strain of Origin:
BTBR
Mutation:
M_BTBR_3_inbred_HM were treated with either vehicle or L. reuteri, added daily in drinking water for 4 weeks.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Sgritta M , et al. (2018) |
Communications | - | Not reported | - | - | Sgritta M , et al. (2018) |
Developmental profile | - | Not reported | - | - | Sgritta M , et al. (2018) |
Emotion | - | Not reported | - | - | Sgritta M , et al. (2018) |
Immune response | - | Not reported | - | - | Sgritta M , et al. (2018) |
Learning & memory | - | Not reported | - | - | Sgritta M , et al. (2018) |
Maternal behavior | - | Not reported | - | - | Sgritta M , et al. (2018) |
Molecular profile | - | Not reported | - | - | Sgritta M , et al. (2018) |
Motor phenotype | - | Not reported | - | - | Sgritta M , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Sgritta M , et al. (2018) |
Neurophysiology | - | Not reported | - | - | Sgritta M , et al. (2018) |
Physiological parameters | - | Not reported | - | - | Sgritta M , et al. (2018) |
Physiological parameters | Intestinal microbiota composition: overall microbiota composition | Refractory | 16s rrna gene sequence analysis for identification of bacteria | 7-10 weeks | Sgritta M , et al. (2018) |
Repetitive behavior | - | Not reported | - | - | Sgritta M , et al. (2018) |
Seizure | - | Not reported | - | - | Sgritta M , et al. (2018) |
Sensory | - | Not reported | - | - | Sgritta M , et al. (2018) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social interaction | Ameliorated | Reciprocal social interaction test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social memory | Ameliorated | Three-chamber social approach test | 7-10 weeks | Sgritta M , et al. (2018) |
M_BTBR_3_INBRED_HM_OXYTOCIN
Model Source:
JAX
Model Type:
RESCUE-Pharmaceutical
Strain of Origin:
BTBR
Mutation:
M_BTBR_3_inbred_HM were treated with oxytocin, intranasally at a dose of 200mg/kg dissolved in 10% DMSO in PBS and tested immediately.
Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
---|---|---|---|---|---|
Circadian sleep/wake cycle | - | Not reported | - | - | Sgritta M , et al. (2018) |
Communications | - | Not reported | - | - | Sgritta M , et al. (2018) |
Developmental profile | - | Not reported | - | - | Sgritta M , et al. (2018) |
Emotion | - | Not reported | - | - | Sgritta M , et al. (2018) |
Immune response | - | Not reported | - | - | Sgritta M , et al. (2018) |
Learning & memory | - | Not reported | - | - | Sgritta M , et al. (2018) |
Maternal behavior | - | Not reported | - | - | Sgritta M , et al. (2018) |
Molecular profile | - | Not reported | - | - | Sgritta M , et al. (2018) |
Motor phenotype | - | Not reported | - | - | Sgritta M , et al. (2018) |
Neuroanatomy / ultrastructure / cytoarchitecture | - | Not reported | - | - | Sgritta M , et al. (2018) |
Neurophysiology | - | Not reported | - | - | Sgritta M , et al. (2018) |
Physiological parameters | - | Not reported | - | - | Sgritta M , et al. (2018) |
Repetitive behavior | - | Not reported | - | - | Sgritta M , et al. (2018) |
Seizure | - | Not reported | - | - | Sgritta M , et al. (2018) |
Sensory | - | Not reported | - | - | Sgritta M , et al. (2018) |
Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social interaction | Ameliorated | Reciprocal social interaction test | 7-10 weeks | Sgritta M , et al. (2018) |
Social behavior | Social memory | Ameliorated | Three-chamber social approach test | 7-10 weeks | Sgritta M , et al. (2018) |
BTBR Rescue Models(43 Models)
M_BTBR_1_INBRED_HM | 1 | Inbred | Inbred | - |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Acetaminophen |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Amphetamine |
M_BTBR_1_INBRED_HM | 1 | Inbred | Dietary | Anti-inflammatory diet |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Atomoxetine |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Buspirone |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | CGS 21680 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Clobazam |
M_BTBR_1_INBRED_HM | 3 | Inbred | Pharmaceutical | Clonazepam |
M_BTBR_1_INBRED_HM | 2 | Inbred | Behavioral | Cross-fostering |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | CX-1739 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | CX-1837 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | CX-546 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | CX-929 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical intervention | D-amphetamine |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | D-Cycloserine |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Delta9-THC |
M_BTBR_1_INBRED_HM | 5 | Inbred | Pharmaceutical | Diazepam |
M_BTBR_1_INBRED_HM | 1 | Inbred | Dietary | Differential amino acid diet |
M_BTBR_1_INBRED_HM | 3 | Inbred | Pharmaceutical | Donepezil |
M_BTBR_1_INBRED_HM | 3 | Inbred | Pharmaceutical | Fluoxetine |
M_BTBR_1_INBRED_HM | 1 | Inbred | Transplantation | Gestational environment |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | GRN-529 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Dietary | Ketogenic diet |
M_BTBR_1_INBRED_HM | 2 | Inbred | Pharmaceutical | L-838,417 |
M_BTBR_1_INBRED_HM | 2 | Inbred | Pharmaceutical | M100907 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical intervention | MDMA |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical intervention | Mercury (II) chloride |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical intervention | Methamphetamine |
M_BTBR_1_INBRED_HM | 6 | Inbred | Pharmaceutical | MPEP |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical intervention | MPTP |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | MTEP |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | Rapamycin |
M_BTBR_1_INBRED_HM | 8 | Inbred | Pharmaceutical | Risperidone |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical intervention | SCH 5826 |
M_BTBR_1_INBRED_HM | 2 | Inbred | Behavioral | Social enrichment |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | TO901317 |
M_BTBR_1_INBRED_HM | 1 | Inbred | Behavioral | Training |
M_BTBR_1_INBRED_HM | 1 | Inbred | Pharmaceutical | WIN 55,212-2 |
M_BTBR_1_INBRED_HM | 2 | Inbred | Pharmaceutical | Zolpidem |
M_BTBR_1_INBRED_HM_SCH | 1 | Pharmaceutical intervention | Pharmaceutical | CGS 21680 |
M_BTBR_3_INBRED_HM | 1 | Inbred | Dietary | Lactobacillus reuteri |
M_BTBR_3_INBRED_HM | 1 | Inbred | Pharmaceutical | Oxytocin |