Induced Animal Models / Polyinosinic:polycytidylic acid

Polyinosinic:polycytidylic acid

Model Species
Mus musculus
Model Subtype
Biological
Reports
15
Inducer Symbol
PolyI:C
Induced Models / Rescue Models
29 / 12
Rescue Model
Yes
Model Summary

A model to experimentally show that prenatal immune activation is an environmental risk factor for adult ventricular enlargement

Human Clinical Evidence

Strong epidemiological evidence suggests that maternal infection during prenatal life may contribute to an increased risk of schizophrenia or autism in offspring

Reports related to Polyinosinic:polycytidylic acid (15 Reports)
# Type Title Author, Year
1 Additional Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons. Canetta S , et al. (2016)
2 Primary Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy. Fortier ME , et al. (2007)
3 Additional Voxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy. Li Q , et al. (2010)
4 Additional Effects of maternal immune activation on gene expression patterns in the fetal brain. Garbett KA , et al. (2012)
5 Additional Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring. Giulivi C , et al. (2013)
6 Additional The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Choi GB , et al. (2016)
7 Primary Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. Shi L , et al. (2003)
8 Additional Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. Li Q , et al. (2009)
9 Additional Modeling an autism risk factor in mice leads to permanent immune dysregulation. Hsiao EY , et al. (2012)
10 Additional Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. Naviaux RK , et al. (2013)
11 Additional Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation. Hemmerle AM , et al. (2015)
12 Additional Maternal immune activation alters fetal brain development through interleukin-6. Smith SE , et al. (2007)
13 Additional Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Malkova NV , et al. (2012)
14 Additional Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. Schwartzer JJ , et al. (2013)
15 Additional Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Hsiao EY , et al. (2013)
Exposure

Prenatal exposure from mother

Mode of Action

Maternal immune activation

Usage

Immunostimulant

Show all Rescue Paradigms Show all Phenotypic Profiles

POLYIC_3_IN_B

Model Source:

Simonson Laboratories

Model Type:

Induced

Strain of Origin:

BALB/c

Construct Definition:

Administration of PolyI:C on E9.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Shi L , et al. (2003)
Communications - Not Reported - - Shi L , et al. (2003)
Developmental profile - Not Reported - - Shi L , et al. (2003)
Emotion - Not Reported - - Shi L , et al. (2003)
Homeostasis - Not Reported - - Shi L , et al. (2003)
Immune response - Not Reported - - Shi L , et al. (2003)
Learning & memory - Not Reported - - Shi L , et al. (2003)
Maternal behavior - Not Reported - - Shi L , et al. (2003)
Molecular profile - Not Reported - - Shi L , et al. (2003)
Motor phenotype - Not Reported - - Shi L , et al. (2003)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Shi L , et al. (2003)
Neurophysiology - Not Reported - - Shi L , et al. (2003)
Repetitive behavior - Not Reported - - Shi L , et al. (2003)
Seizure - Not Reported - - Shi L , et al. (2003)
Sensory AM1500014 Decreased Prepulse inhibition 4-8 weeks Shi L , et al. (2003)
Social behavior - Not Reported - - Shi L , et al. (2003)

R_POLYIC_1_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

Sprague Dawley

Construct Definition:

Administration of Poly(I:C), injected twice in consecutive days

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Fortier ME , et al. (2007)
Communications - Not Reported - - Fortier ME , et al. (2007)
Developmental profile AM300002 No Change General observations P0 Fortier ME , et al. (2007)
Emotion - Not Reported - - Fortier ME , et al. (2007)
Homeostasis - Not Reported - - Fortier ME , et al. (2007)
Immune response - Not Reported - - Fortier ME , et al. (2007)
Learning & memory - Not Reported - - Fortier ME , et al. (2007)
Maternal behavior - Not Reported - - Fortier ME , et al. (2007)
Molecular profile - Not Reported - - Fortier ME , et al. (2007)
Motor phenotype - Not Reported - - Fortier ME , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Fortier ME , et al. (2007)
Neurophysiology - Not Reported - - Fortier ME , et al. (2007)
Repetitive behavior - Not Reported - - Fortier ME , et al. (2007)
Seizure - Not Reported - - Fortier ME , et al. (2007)
Sensory AM1500000 No Change Acoustic startle reflex test 2-3 months Fortier ME , et al. (2007)
Sensory AM1500014 No Change Prepulse inhibition 2-3 months Fortier ME , et al. (2007)
Social behavior - Not Reported - - Fortier ME , et al. (2007)

R_POLYIC_2_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

Sprague Dawley

Construct Definition:

Administration of Poly(I:C), injected twice in consecutive days

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Fortier ME , et al. (2007)
Communications - Not Reported - - Fortier ME , et al. (2007)
Developmental profile AM300002 No Change General observations P0 Fortier ME , et al. (2007)
Emotion - Not Reported - - Fortier ME , et al. (2007)
Homeostasis - Not Reported - - Fortier ME , et al. (2007)
Immune response - Not Reported - - Fortier ME , et al. (2007)
Learning & memory - Not Reported - - Fortier ME , et al. (2007)
Maternal behavior - Not Reported - - Fortier ME , et al. (2007)
Molecular profile - Not Reported - - Fortier ME , et al. (2007)
Motor phenotype - Not Reported - - Fortier ME , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Fortier ME , et al. (2007)
Neurophysiology - Not Reported - - Fortier ME , et al. (2007)
Repetitive behavior - Not Reported - - Fortier ME , et al. (2007)
Seizure - Not Reported - - Fortier ME , et al. (2007)
Sensory AM1500000 No Change Acoustic startle reflex test 2-3 months Fortier ME , et al. (2007)
Sensory AM1500014 No Change Prepulse inhibition 2-3 months Fortier ME , et al. (2007)
Social behavior - Not Reported - - Fortier ME , et al. (2007)

POLYIC_6_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Giulivi C , et al. (2013)
Communications - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Garbett KA , et al. (2012)
Communications - Not Reported - - Giulivi C , et al. (2013)
Communications AM200001 Increased Monitoring ultrasonic vocalizations: maternal separation P10 Schwartzer JJ , et al. (2013)
Communications AM200001 No Change Monitoring ultrasonic vocalizations: maternal separation P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Giulivi C , et al. (2013)
Developmental profile AM300018 Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not Reported - - Garbett KA , et al. (2012)
Emotion - Not Reported - - Schwartzer JJ , et al. (2013)
Emotion - Not Reported - - Giulivi C , et al. (2013)
Emotion AM400001 Increased Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Homeostasis - Not Reported - - Garbett KA , et al. (2012)
Homeostasis - Not Reported - - Schwartzer JJ , et al. (2013)
Homeostasis - Not Reported - - Giulivi C , et al. (2013)
Immune response - Not Reported - - Smith SE , et al. (2007)
Immune response - Not Reported - - Garbett KA , et al. (2012)
Immune response - Not Reported - - Giulivi C , et al. (2013)
Immune response AM600009 No Change Stimulation of immune cells: splenocytes Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Garbett KA , et al. (2012)
Learning & memory - Not Reported - - Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Giulivi C , et al. (2013)
Learning & memory AM700010 Decreased Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Garbett KA , et al. (2012)
Maternal behavior - Not Reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not Reported - - Giulivi C , et al. (2013)
Molecular profile - Not Reported - - Schwartzer JJ , et al. (2013)
Molecular profile AM900016 Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Molecular profile AM900016 Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 No Change Quantitative PCR (qRT-PCR) 3.5, 12 months Garbett KA , et al. (2012)
Molecular profile AM900035 Decreased Mitochondrial oxygen consumption studies: permeablized splenocytes 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not Reported - - Garbett KA , et al. (2012)
Motor phenotype - Not Reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not Reported - - Giulivi C , et al. (2013)
Motor phenotype AM1000009 Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Garbett KA , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Giulivi C , et al. (2013)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Garbett KA , et al. (2012)
Neurophysiology - Not Reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior AM1300012 Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Garbett KA , et al. (2012)
Seizure - Not Reported - - Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Giulivi C , et al. (2013)
Sensory - Not Reported - - Garbett KA , et al. (2012)
Sensory - Not Reported - - Schwartzer JJ , et al. (2013)
Sensory - Not Reported - - Giulivi C , et al. (2013)
Sensory AM1500014 Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior - Not Reported - - Garbett KA , et al. (2012)
Social behavior - Not Reported - - Giulivi C , et al. (2013)
Social behavior AM1600010 No Change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)

POLYIC_6_IN_B_AIL6

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5, co-administration of 100 microg of anti-IL-6, rat IgG1

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Emotion AM400001 Restored Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Immune response - Not Reported - - Smith SE , et al. (2007)
Learning & memory AM700010 Restored Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Molecular profile AM900016 Ameliorated Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype AM1000009 Restored Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Smith SE , et al. (2007)
Sensory AM1500014 Restored Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior AM1600012 Restored Three-chamber social approach test Adult Smith SE , et al. (2007)

POLYIC_6_IN_B_IL6_KO

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J (backcrossed 11 generations from B6.129S2-IL6tm1Kopf/J)

Construct Definition:

Administration of PolyI:C on E12.5 in IL6 knockout

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Choi GB , et al. (2016)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Emotion AM400001 Restored Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response - Not Reported - - Smith SE , et al. (2007)
Immune response AM600019 Restored ELISA: maternal sera at E14.5 E14.5 Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Learning & memory AM700010 Abnormal Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Smith SE , et al. (2007)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype - Not Reported - - Choi GB , et al. (2016)
Motor phenotype AM1000009 Restored Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Choi GB , et al. (2016)
Seizure - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Sensory AM1500014 Restored Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Restored Three-chamber social approach test Adult Smith SE , et al. (2007)

POLYIC_1_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E9 and E17 in 5 ml/kg

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Li Q , et al. (2009)
Communications - Not Reported - - Li Q , et al. (2009)
Developmental profile - Not Reported - - Li Q , et al. (2009)
Emotion - Not Reported - - Li Q , et al. (2009)
Homeostasis - Not Reported - - Li Q , et al. (2009)
Immune response - Not Reported - - Li Q , et al. (2009)
Learning & memory - Not Reported - - Li Q , et al. (2009)
Maternal behavior - Not Reported - - Li Q , et al. (2009)
Molecular profile - Not Reported - - Li Q , et al. (2009)
Motor phenotype - Not Reported - - Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100004 Abnormal Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100005 No Change Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neurophysiology - Not Reported - - Li Q , et al. (2009)
Repetitive behavior - Not Reported - - Li Q , et al. (2009)
Seizure - Not Reported - - Li Q , et al. (2009)
Sensory AM1500014 Abnormal Prepulse inhibition 12 weeks Li Q , et al. (2009)
Social behavior - Not Reported - - Li Q , et al. (2009)

POLYIC_2_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E17 in 5 ml/kg

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Li Q , et al. (2009)
Circadian sleep/wake cycle - Not Reported - - Li Q , et al. (2010)
Communications - Not Reported - - Li Q , et al. (2009)
Communications - Not Reported - - Li Q , et al. (2010)
Developmental profile - Not Reported - - Li Q , et al. (2009)
Developmental profile - Not Reported - - Li Q , et al. (2010)
Emotion - Not Reported - - Li Q , et al. (2009)
Emotion - Not Reported - - Li Q , et al. (2010)
Homeostasis - Not Reported - - Li Q , et al. (2009)
Homeostasis - Not Reported - - Li Q , et al. (2010)
Immune response - Not Reported - - Li Q , et al. (2009)
Immune response - Not Reported - - Li Q , et al. (2010)
Learning & memory - Not Reported - - Li Q , et al. (2009)
Learning & memory - Not Reported - - Li Q , et al. (2010)
Maternal behavior - Not Reported - - Li Q , et al. (2009)
Maternal behavior - Not Reported - - Li Q , et al. (2010)
Molecular profile - Not Reported - - Li Q , et al. (2009)
Molecular profile - Not Reported - - Li Q , et al. (2010)
Motor phenotype - Not Reported - - Li Q , et al. (2009)
Motor phenotype - Not Reported - - Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100004 Abnormal Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100004 No Change Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100005 No Change Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100011 Abnormal Diffusion tensor imaging 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100011 Abnormal Diffusion tensor imaging 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100026 No Change Immunohistochemistry Unreported Li Q , et al. (2010)
Neurophysiology - Not Reported - - Li Q , et al. (2009)
Neurophysiology - Not Reported - - Li Q , et al. (2010)
Repetitive behavior - Not Reported - - Li Q , et al. (2009)
Repetitive behavior - Not Reported - - Li Q , et al. (2010)
Seizure - Not Reported - - Li Q , et al. (2009)
Seizure - Not Reported - - Li Q , et al. (2010)
Sensory - Not Reported - - Li Q , et al. (2010)
Sensory AM1500014 No Change Prepulse inhibition 12 weeks Li Q , et al. (2009)
Social behavior - Not Reported - - Li Q , et al. (2009)
Social behavior - Not Reported - - Li Q , et al. (2010)

POLYIC_2_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E17 in 5 ml/kg

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Li Q , et al. (2009)
Circadian sleep/wake cycle - Not Reported - - Li Q , et al. (2010)
Communications - Not Reported - - Li Q , et al. (2009)
Communications - Not Reported - - Li Q , et al. (2010)
Developmental profile - Not Reported - - Li Q , et al. (2009)
Developmental profile - Not Reported - - Li Q , et al. (2010)
Emotion - Not Reported - - Li Q , et al. (2009)
Emotion - Not Reported - - Li Q , et al. (2010)
Homeostasis - Not Reported - - Li Q , et al. (2009)
Homeostasis - Not Reported - - Li Q , et al. (2010)
Immune response - Not Reported - - Li Q , et al. (2009)
Immune response - Not Reported - - Li Q , et al. (2010)
Learning & memory - Not Reported - - Li Q , et al. (2009)
Learning & memory - Not Reported - - Li Q , et al. (2010)
Maternal behavior - Not Reported - - Li Q , et al. (2009)
Maternal behavior - Not Reported - - Li Q , et al. (2010)
Molecular profile - Not Reported - - Li Q , et al. (2009)
Molecular profile - Not Reported - - Li Q , et al. (2010)
Motor phenotype - Not Reported - - Li Q , et al. (2009)
Motor phenotype - Not Reported - - Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100004 Abnormal Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100004 No Change Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100005 No Change Magnetic resonance imaging (MRI) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100011 Abnormal Diffusion tensor imaging 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100011 Abnormal Diffusion tensor imaging 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100026 No Change Immunohistochemistry Unreported Li Q , et al. (2010)
Neurophysiology - Not Reported - - Li Q , et al. (2009)
Neurophysiology - Not Reported - - Li Q , et al. (2010)
Repetitive behavior - Not Reported - - Li Q , et al. (2009)
Repetitive behavior - Not Reported - - Li Q , et al. (2010)
Seizure - Not Reported - - Li Q , et al. (2009)
Seizure - Not Reported - - Li Q , et al. (2010)
Sensory - Not Reported - - Li Q , et al. (2010)
Sensory AM1500014 No Change Prepulse inhibition 12 weeks Li Q , et al. (2009)
Social behavior - Not Reported - - Li Q , et al. (2009)
Social behavior - Not Reported - - Li Q , et al. (2010)

POLYIC_4_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E9 in 5 ml/kg

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Li Q , et al. (2010)
Communications - Not Reported - - Li Q , et al. (2010)
Developmental profile - Not Reported - - Li Q , et al. (2010)
Emotion - Not Reported - - Li Q , et al. (2010)
Homeostasis - Not Reported - - Li Q , et al. (2010)
Immune response - Not Reported - - Li Q , et al. (2010)
Learning & memory - Not Reported - - Li Q , et al. (2010)
Maternal behavior - Not Reported - - Li Q , et al. (2010)
Molecular profile - Not Reported - - Li Q , et al. (2010)
Motor phenotype - Not Reported - - Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100011 Abnormal Diffusion tensor imaging 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100011 Abnormal Diffusion tensor imaging 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100026 Decreased Immunohistochemistry Unreported Li Q , et al. (2010)
Neurophysiology - Not Reported - - Li Q , et al. (2010)
Repetitive behavior - Not Reported - - Li Q , et al. (2010)
Seizure - Not Reported - - Li Q , et al. (2010)
Sensory - Not Reported - - Li Q , et al. (2010)
Social behavior - Not Reported - - Li Q , et al. (2010)

POLYIC_5_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E10.5, E12.5, and E14.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Malkova NV , et al. (2012)
Communications AM200001 Decreased Monitoring ultrasonic vocalizations: reciprocal social interaction test 8-9 weeks Malkova NV , et al. (2012)
Communications AM200001 Decreased Monitoring ultrasonic vocalizations: reciprocal social interaction test: male-female 8-9 weeks Malkova NV , et al. (2012)
Communications AM200001 Decreased Monitoring ultrasonic vocalizations: maternal separation 10 days Malkova NV , et al. (2012)
Developmental profile AM300002 No Change General observations Unreported Malkova NV , et al. (2012)
Emotion - Not Reported - - Malkova NV , et al. (2012)
Homeostasis - Not Reported - - Malkova NV , et al. (2012)
Immune response - Not Reported - - Malkova NV , et al. (2012)
Learning & memory - Not Reported - - Malkova NV , et al. (2012)
Maternal behavior AM800002 No Change General observations Unreported Malkova NV , et al. (2012)
Maternal behavior AM800005 No Change Pup retrieval assay Unreported Malkova NV , et al. (2012)
Molecular profile - Not Reported - - Malkova NV , et al. (2012)
Motor phenotype - Not Reported - - Malkova NV , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Malkova NV , et al. (2012)
Neurophysiology - Not Reported - - Malkova NV , et al. (2012)
Repetitive behavior AM1300009 Increased Grooming behavior assessments 13 weeks Malkova NV , et al. (2012)
Repetitive behavior AM1300012 Increased Marble-burying test 12 weeks Malkova NV , et al. (2012)
Seizure - Not Reported - - Malkova NV , et al. (2012)
Sensory AM1500002 No Change Negative geotaxis test; Grasping reflex test; Righting reflex test Unreported Malkova NV , et al. (2012)
Sensory AM1500011 No Change Olfactory discrimination test 13-14 weeks Malkova NV , et al. (2012)
Social behavior AM1600005 Decreased Scent marking test 11 weeks Malkova NV , et al. (2012)
Social behavior AM1600014 Decreased Three-chamber social approach test 10 weeks Malkova NV , et al. (2012)

POLYIC_7_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2013)
Communications - Not Reported - - Hsiao EY , et al. (2012)
Communications AM200001 Decreased - 6 weeks Hsiao EY , et al. (2013)
Developmental profile - Not Reported - - Hsiao EY , et al. (2012)
Developmental profile - Not Reported - - Hsiao EY , et al. (2013)
Emotion AM400001 Increased Open field test Unreported Hsiao EY , et al. (2012)
Emotion AM400001 Increased Open field test 6 weeks Hsiao EY , et al. (2013)
Homeostasis - Not Reported - - Hsiao EY , et al. (2012)
Homeostasis AM500005 Decreased Intestinal permeability test 3 weeks, adult Hsiao EY , et al. (2013)
Homeostasis AM500001 Abnormal 16S rRNA gene sequence analysis for identification of bacteria Unreported Hsiao EY , et al. (2013)
Immune response AM600004 Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600004 Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600004 No Change Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600009 Decreased - Unreported Hsiao EY , et al. (2013)
Immune response AM600009 Increased - Unreported Hsiao EY , et al. (2013)
Immune response AM600009 Decreased - Unreported Hsiao EY , et al. (2013)
Immune response AM600012 Increased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600014 Abnormal Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Learning & memory - Not Reported - - Hsiao EY , et al. (2012)
Learning & memory - Not Reported - - Hsiao EY , et al. (2013)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2013)
Molecular profile - Not Reported - - Hsiao EY , et al. (2012)
Molecular profile AM900040 Decreased Quantitative PCR (qRT-PCR) Adult Hsiao EY , et al. (2013)
Molecular profile AM900040 Increased Quantitative PCR (qRT-PCR) Adult Hsiao EY , et al. (2013)
Motor phenotype - Not Reported - - Hsiao EY , et al. (2012)
Motor phenotype - Not Reported - - Hsiao EY , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2013)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2013)
Repetitive behavior AM1300007 Increased Marble-burying test Unreported Hsiao EY , et al. (2012)
Repetitive behavior AM1300007 Increased Marble-burying test 6 weeks Hsiao EY , et al. (2013)
Seizure - Not Reported - - Hsiao EY , et al. (2012)
Seizure - Not Reported - - Hsiao EY , et al. (2013)
Sensory AM1500014 Decreased Prepulse inhibition Unreported Hsiao EY , et al. (2012)
Sensory AM1500014 Decreased Prepulse inhibition 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test Unreported Hsiao EY , et al. (2012)

POLYIC_7_IN_B_BM

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5 followed by radiation and injection of bone marrow cells from polyI:C offspring

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2012)
Communications - Not Reported - - Hsiao EY , et al. (2012)
Developmental profile - Not Reported - - Hsiao EY , et al. (2012)
Emotion AM400001 Restored Open field test 17-19 weeks Hsiao EY , et al. (2012)
Homeostasis - Not Reported - - Hsiao EY , et al. (2012)
Immune response AM600004 Restored Flow cytometric analysis 19-20 weeks Hsiao EY , et al. (2012)
Immune response AM600009 Restored Flow cytometric analysis 19-20 weeks Hsiao EY , et al. (2012)
Immune response AM600012 Restored Flow cytometric analysis 19-20 weeks Hsiao EY , et al. (2012)
Learning & memory - Not Reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2012)
Molecular profile - Not Reported - - Hsiao EY , et al. (2012)
Motor phenotype AM1000008 Side Effect Open field test 17-19 weeks Hsiao EY , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2012)
Repetitive behavior AM1300007 Restored Marble-burying test 17-19 weeks Hsiao EY , et al. (2012)
Seizure - Not Reported - - Hsiao EY , et al. (2012)
Sensory - Not Reported - - Hsiao EY , et al. (2012)
Social behavior AM1600014 Refractory Three-chamber social approach test 17-19 weeks Hsiao EY , et al. (2012)

POLYIC_7_IN_B_BM_S

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5 followed by radiation and injection of bone marrow cells from saline offspring

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2012)
Communications - Not Reported - - Hsiao EY , et al. (2012)
Developmental profile - Not Reported - - Hsiao EY , et al. (2012)
Emotion AM400001 Restored Open field test 4 months Hsiao EY , et al. (2012)
Homeostasis - Not Reported - - Hsiao EY , et al. (2012)
Immune response AM600004 Restored Flow cytometric analysis 4.5 months Hsiao EY , et al. (2012)
Immune response AM600009 Restored Flow cytometric analysis 4.5 months Hsiao EY , et al. (2012)
Immune response AM600012 Restored Flow cytometric analysis 4.5 months Hsiao EY , et al. (2012)
Learning & memory - Not Reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2012)
Molecular profile - Not Reported - - Hsiao EY , et al. (2012)
Motor phenotype AM1000008 Side Effect Open field test 4 months Hsiao EY , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2012)
Repetitive behavior AM1300007 Restored Marble-burying test 4 months Hsiao EY , et al. (2012)
Seizure - Not Reported - - Hsiao EY , et al. (2012)
Sensory - Not Reported - - Hsiao EY , et al. (2012)
Social behavior AM1600014 Refractory Three-chamber social approach test 4 months Hsiao EY , et al. (2012)

POLYIC_6_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Giulivi C , et al. (2013)
Communications - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Garbett KA , et al. (2012)
Communications - Not Reported - - Giulivi C , et al. (2013)
Communications AM200001 Increased Monitoring ultrasonic vocalizations: maternal separation P10 Schwartzer JJ , et al. (2013)
Communications AM200001 No Change Monitoring ultrasonic vocalizations: maternal separation P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Giulivi C , et al. (2013)
Developmental profile AM300018 Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not Reported - - Garbett KA , et al. (2012)
Emotion - Not Reported - - Schwartzer JJ , et al. (2013)
Emotion - Not Reported - - Giulivi C , et al. (2013)
Emotion AM400001 Increased Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Homeostasis - Not Reported - - Garbett KA , et al. (2012)
Homeostasis - Not Reported - - Schwartzer JJ , et al. (2013)
Homeostasis - Not Reported - - Giulivi C , et al. (2013)
Immune response - Not Reported - - Smith SE , et al. (2007)
Immune response - Not Reported - - Garbett KA , et al. (2012)
Immune response - Not Reported - - Giulivi C , et al. (2013)
Immune response AM600009 No Change Stimulation of immune cells: splenocytes Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Garbett KA , et al. (2012)
Learning & memory - Not Reported - - Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Giulivi C , et al. (2013)
Learning & memory AM700010 Decreased Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Garbett KA , et al. (2012)
Maternal behavior - Not Reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not Reported - - Giulivi C , et al. (2013)
Molecular profile - Not Reported - - Schwartzer JJ , et al. (2013)
Molecular profile AM900016 Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Molecular profile AM900016 Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 No Change Quantitative PCR (qRT-PCR) 3.5, 12 months Garbett KA , et al. (2012)
Molecular profile AM900035 Decreased Mitochondrial oxygen consumption studies: permeablized splenocytes 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not Reported - - Garbett KA , et al. (2012)
Motor phenotype - Not Reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not Reported - - Giulivi C , et al. (2013)
Motor phenotype AM1000009 Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Garbett KA , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Giulivi C , et al. (2013)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Garbett KA , et al. (2012)
Neurophysiology - Not Reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior AM1300012 Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Garbett KA , et al. (2012)
Seizure - Not Reported - - Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Giulivi C , et al. (2013)
Sensory - Not Reported - - Garbett KA , et al. (2012)
Sensory - Not Reported - - Schwartzer JJ , et al. (2013)
Sensory - Not Reported - - Giulivi C , et al. (2013)
Sensory AM1500014 Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior - Not Reported - - Garbett KA , et al. (2012)
Social behavior - Not Reported - - Giulivi C , et al. (2013)
Social behavior AM1600010 No Change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)

POLYIC_6_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Giulivi C , et al. (2013)
Communications - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Garbett KA , et al. (2012)
Communications - Not Reported - - Giulivi C , et al. (2013)
Communications AM200001 Increased Monitoring ultrasonic vocalizations: maternal separation P10 Schwartzer JJ , et al. (2013)
Communications AM200001 No Change Monitoring ultrasonic vocalizations: maternal separation P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Giulivi C , et al. (2013)
Developmental profile AM300018 Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not Reported - - Garbett KA , et al. (2012)
Emotion - Not Reported - - Schwartzer JJ , et al. (2013)
Emotion - Not Reported - - Giulivi C , et al. (2013)
Emotion AM400001 Increased Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Homeostasis - Not Reported - - Garbett KA , et al. (2012)
Homeostasis - Not Reported - - Schwartzer JJ , et al. (2013)
Homeostasis - Not Reported - - Giulivi C , et al. (2013)
Immune response - Not Reported - - Smith SE , et al. (2007)
Immune response - Not Reported - - Garbett KA , et al. (2012)
Immune response - Not Reported - - Giulivi C , et al. (2013)
Immune response AM600009 No Change Stimulation of immune cells: splenocytes Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Garbett KA , et al. (2012)
Learning & memory - Not Reported - - Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Giulivi C , et al. (2013)
Learning & memory AM700010 Decreased Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Garbett KA , et al. (2012)
Maternal behavior - Not Reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not Reported - - Giulivi C , et al. (2013)
Molecular profile - Not Reported - - Schwartzer JJ , et al. (2013)
Molecular profile AM900016 Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Molecular profile AM900016 Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 No Change Quantitative PCR (qRT-PCR) 3.5, 12 months Garbett KA , et al. (2012)
Molecular profile AM900035 Decreased Mitochondrial oxygen consumption studies: permeablized splenocytes 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not Reported - - Garbett KA , et al. (2012)
Motor phenotype - Not Reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not Reported - - Giulivi C , et al. (2013)
Motor phenotype AM1000009 Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Garbett KA , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Giulivi C , et al. (2013)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Garbett KA , et al. (2012)
Neurophysiology - Not Reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior AM1300012 Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Garbett KA , et al. (2012)
Seizure - Not Reported - - Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Giulivi C , et al. (2013)
Sensory - Not Reported - - Garbett KA , et al. (2012)
Sensory - Not Reported - - Schwartzer JJ , et al. (2013)
Sensory - Not Reported - - Giulivi C , et al. (2013)
Sensory AM1500014 Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior - Not Reported - - Garbett KA , et al. (2012)
Social behavior - Not Reported - - Giulivi C , et al. (2013)
Social behavior AM1600010 No Change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)

POLYIC_8_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

BTBR

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Schwartzer JJ , et al. (2013)
Communications AM200001 Increased Monitoring ultrasonic vocalizations: maternal separation P8, P10 Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Schwartzer JJ , et al. (2013)
Emotion - Not Reported - - Schwartzer JJ , et al. (2013)
Homeostasis - Not Reported - - Schwartzer JJ , et al. (2013)
Immune response AM600009 Abnormal Stimulation of immune cells: splenocytes Unreported Schwartzer JJ , et al. (2013)
Immune response AM600009 No Change Stimulation of immune cells: splenocytes Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not Reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not Reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not Reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not Reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior AM1300012 Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Schwartzer JJ , et al. (2013)
Sensory - Not Reported - - Schwartzer JJ , et al. (2013)
Social behavior AM1600010 Increased Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior AM1600010 No Change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)

POLYIC_10_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5 (3 mg/kg) and E17.5 (0.125 mg/kg)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Naviaux RK , et al. (2013)
Communications - Not Reported - - Naviaux RK , et al. (2013)
Developmental profile - Not Reported - - Naviaux RK , et al. (2013)
Emotion - Not Reported - - Naviaux RK , et al. (2013)
Homeostasis - Not Reported - - Naviaux RK , et al. (2013)
Immune response - Not Reported - - Naviaux RK , et al. (2013)
Learning & memory - Not Reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not Reported - - Naviaux RK , et al. (2013)
Molecular profile - Not Reported - - Naviaux RK , et al. (2013)
Motor phenotype AM1000021 No Change Accelerating rotarod test 8 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Naviaux RK , et al. (2013)
Neurophysiology - Not Reported - - Naviaux RK , et al. (2013)
Repetitive behavior - Not Reported - - Naviaux RK , et al. (2013)
Seizure - Not Reported - - Naviaux RK , et al. (2013)
Sensory - Not Reported - - Naviaux RK , et al. (2013)
Social behavior - Not Reported - - Naviaux RK , et al. (2013)

POLYIC_9_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Naviaux RK , et al. (2013)
Communications - Not Reported - - Naviaux RK , et al. (2013)
Developmental profile - Not Reported - - Naviaux RK , et al. (2013)
Emotion - Not Reported - - Naviaux RK , et al. (2013)
Homeostasis AM500003 Decreased - 8 weeks Naviaux RK , et al. (2013)
Homeostasis AM500014 Increased Mitochondrial respiratory chain enzyme analysis Unreported Naviaux RK , et al. (2013)
Immune response - Not Reported - - Naviaux RK , et al. (2013)
Immune response AM600001 No Change Antibody levels 15 weeks Naviaux RK , et al. (2013)
Learning & memory - Not Reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not Reported - - Naviaux RK , et al. (2013)
Molecular profile AM900031 Decreased Western blot Unreported Naviaux RK , et al. (2013)
Molecular profile AM900031 Decreased Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile AM900031 No Change Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile AM900043 Decreased Western blot 16 weeks Naviaux RK , et al. (2013)
Motor phenotype AM1000021 Decreased Accelerating rotarod test 8 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100041 Increased Histology 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100058 Abnormal Electron microscopy Unreported Naviaux RK , et al. (2013)
Neurophysiology - Not Reported - - Naviaux RK , et al. (2013)
Repetitive behavior - Not Reported - - Naviaux RK , et al. (2013)
Seizure - Not Reported - - Naviaux RK , et al. (2013)
Sensory - Not Reported - - Naviaux RK , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test 8 weeks Naviaux RK , et al. (2013)

POLYIC_9_IN_B_SUR

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5 followed by weekly intraperitoneal administration of 10 or 20 mg/kg of suramin starting at 6 weeks of age

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Naviaux RK , et al. (2013)
Communications - Not Reported - - Naviaux RK , et al. (2013)
Developmental profile AM300002 No Adverse Effect General observations 14 weeks Naviaux RK , et al. (2013)
Emotion - Not Reported - - Naviaux RK , et al. (2013)
Homeostasis AM500003 Restored Body temperature measurement 6 weeks Naviaux RK , et al. (2013)
Homeostasis AM500006 Increased Radioimmunoassay (RIA): corticosterone 15 weeks Naviaux RK , et al. (2013)
Homeostasis AM500011 Side Effect Comprehensive metabolic evaluation 14 weeks Naviaux RK , et al. (2013)
Homeostasis AM500014 Increased Mitochondrial respiratory chain enzyme analysis 16 weeks Naviaux RK , et al. (2013)
Immune response - Not Reported - - Naviaux RK , et al. (2013)
Immune response AM600001 Increased Antibody levels 15 weeks Naviaux RK , et al. (2013)
Learning & memory - Not Reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not Reported - - Naviaux RK , et al. (2013)
Molecular profile AM900031 Restored Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile AM900031 Restored Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile AM900031 Side Effect Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile AM900043 Restored Western blot 16 weeks Naviaux RK , et al. (2013)
Motor phenotype AM1000008 No Adverse Effect Open field test 14 weeks Naviaux RK , et al. (2013)
Motor phenotype AM1000021 Restored Accelerating rotarod test 8 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100041 Restored Histology 6 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100058 Restored Electron microscopy 16 weeks Naviaux RK , et al. (2013)
Neurophysiology - Not Reported - - Naviaux RK , et al. (2013)
Repetitive behavior - Not Reported - - Naviaux RK , et al. (2013)
Seizure - Not Reported - - Naviaux RK , et al. (2013)
Sensory - Not Reported - - Naviaux RK , et al. (2013)
Social behavior AM1600014 Restored Three-chamber social approach test 8 weeks Naviaux RK , et al. (2013)

POLYIC_6_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not Reported - - Giulivi C , et al. (2013)
Communications - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Garbett KA , et al. (2012)
Communications - Not Reported - - Giulivi C , et al. (2013)
Communications AM200001 Increased Monitoring ultrasonic vocalizations: maternal separation P10 Schwartzer JJ , et al. (2013)
Communications AM200001 No Change Monitoring ultrasonic vocalizations: maternal separation P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Schwartzer JJ , et al. (2013)
Developmental profile - Not Reported - - Giulivi C , et al. (2013)
Developmental profile AM300018 Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not Reported - - Garbett KA , et al. (2012)
Emotion - Not Reported - - Schwartzer JJ , et al. (2013)
Emotion - Not Reported - - Giulivi C , et al. (2013)
Emotion AM400001 Increased Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Homeostasis - Not Reported - - Garbett KA , et al. (2012)
Homeostasis - Not Reported - - Schwartzer JJ , et al. (2013)
Homeostasis - Not Reported - - Giulivi C , et al. (2013)
Immune response - Not Reported - - Smith SE , et al. (2007)
Immune response - Not Reported - - Garbett KA , et al. (2012)
Immune response - Not Reported - - Giulivi C , et al. (2013)
Immune response AM600009 No Change Stimulation of immune cells: splenocytes Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Garbett KA , et al. (2012)
Learning & memory - Not Reported - - Schwartzer JJ , et al. (2013)
Learning & memory - Not Reported - - Giulivi C , et al. (2013)
Learning & memory AM700010 Decreased Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Garbett KA , et al. (2012)
Maternal behavior - Not Reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not Reported - - Giulivi C , et al. (2013)
Molecular profile - Not Reported - - Schwartzer JJ , et al. (2013)
Molecular profile AM900016 Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Molecular profile AM900016 Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile AM900016 No Change Quantitative PCR (qRT-PCR) 3.5, 12 months Garbett KA , et al. (2012)
Molecular profile AM900035 Decreased Mitochondrial oxygen consumption studies: permeablized splenocytes 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not Reported - - Garbett KA , et al. (2012)
Motor phenotype - Not Reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not Reported - - Giulivi C , et al. (2013)
Motor phenotype AM1000009 Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Garbett KA , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Giulivi C , et al. (2013)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Garbett KA , et al. (2012)
Neurophysiology - Not Reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not Reported - - Giulivi C , et al. (2013)
Repetitive behavior AM1300012 Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Garbett KA , et al. (2012)
Seizure - Not Reported - - Schwartzer JJ , et al. (2013)
Seizure - Not Reported - - Giulivi C , et al. (2013)
Sensory - Not Reported - - Garbett KA , et al. (2012)
Sensory - Not Reported - - Schwartzer JJ , et al. (2013)
Sensory - Not Reported - - Giulivi C , et al. (2013)
Sensory AM1500014 Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior - Not Reported - - Garbett KA , et al. (2012)
Social behavior - Not Reported - - Giulivi C , et al. (2013)
Social behavior AM1600010 No Change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test: sociability 10 weeks Schwartzer JJ , et al. (2013)

POLYIC_7_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2012)
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2013)
Communications - Not Reported - - Hsiao EY , et al. (2012)
Communications AM200001 Decreased - 6 weeks Hsiao EY , et al. (2013)
Developmental profile - Not Reported - - Hsiao EY , et al. (2012)
Developmental profile - Not Reported - - Hsiao EY , et al. (2013)
Emotion AM400001 Increased Open field test Unreported Hsiao EY , et al. (2012)
Emotion AM400001 Increased Open field test 6 weeks Hsiao EY , et al. (2013)
Homeostasis - Not Reported - - Hsiao EY , et al. (2012)
Homeostasis AM500005 Decreased Intestinal permeability test 3 weeks, adult Hsiao EY , et al. (2013)
Homeostasis AM500001 Abnormal 16S rRNA gene sequence analysis for identification of bacteria Unreported Hsiao EY , et al. (2013)
Immune response AM600004 Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600004 Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600004 No Change Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600009 Decreased - Unreported Hsiao EY , et al. (2013)
Immune response AM600009 Increased - Unreported Hsiao EY , et al. (2013)
Immune response AM600009 Decreased - Unreported Hsiao EY , et al. (2013)
Immune response AM600012 Increased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response AM600014 Abnormal Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Learning & memory - Not Reported - - Hsiao EY , et al. (2012)
Learning & memory - Not Reported - - Hsiao EY , et al. (2013)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2013)
Molecular profile - Not Reported - - Hsiao EY , et al. (2012)
Molecular profile AM900040 Decreased Quantitative PCR (qRT-PCR) Adult Hsiao EY , et al. (2013)
Molecular profile AM900040 Increased Quantitative PCR (qRT-PCR) Adult Hsiao EY , et al. (2013)
Motor phenotype - Not Reported - - Hsiao EY , et al. (2012)
Motor phenotype - Not Reported - - Hsiao EY , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2012)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2013)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2013)
Repetitive behavior AM1300007 Increased Marble-burying test Unreported Hsiao EY , et al. (2012)
Repetitive behavior AM1300007 Increased Marble-burying test 6 weeks Hsiao EY , et al. (2013)
Seizure - Not Reported - - Hsiao EY , et al. (2012)
Seizure - Not Reported - - Hsiao EY , et al. (2013)
Sensory AM1500014 Decreased Prepulse inhibition Unreported Hsiao EY , et al. (2012)
Sensory AM1500014 Decreased Prepulse inhibition 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600012 Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600014 Decreased Three-chamber social approach test Unreported Hsiao EY , et al. (2012)

POLYIC_7_IN_B_GUT

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL6/N

Construct Definition:

Administration of PolyI:C on E12.5 followed by oral administration of B. fragilis NCTC 9343 every other day for 6 days at weaning

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hsiao EY , et al. (2013)
Communications AM200001 Restored - 6 weeks Hsiao EY , et al. (2013)
Developmental profile - Not Reported - - Hsiao EY , et al. (2013)
Emotion AM400001 Restored Open field test 6 weeks Hsiao EY , et al. (2013)
Homeostasis AM500005 Restored Intestinal permeability test 8 weeks Hsiao EY , et al. (2013)
Homeostasis AM500001 Ameliorated 16S rRNA gene sequence analysis for identification of bacteria Unreported Hsiao EY , et al. (2013)
Immune response AM600009 Restored Cytokine level detection: mRNA and protein 8 weeks Hsiao EY , et al. (2013)
Learning & memory - Not Reported - - Hsiao EY , et al. (2013)
Maternal behavior - Not Reported - - Hsiao EY , et al. (2013)
Molecular profile AM900022 Restored Gas chromatography-mass spectrometry (GC-MS) Adult Hsiao EY , et al. (2013)
Molecular profile AM900040 Restored Quantitative PCR (qRT-PCR) 8 weeks Hsiao EY , et al. (2013)
Molecular profile AM900040 Refractory Quantitative PCR (qRT-PCR) 6 weeks Hsiao EY , et al. (2013)
Molecular profile AM900040 Ameliorated Quantitative PCR (qRT-PCR) 8 weeks Hsiao EY , et al. (2013)
Motor phenotype AM1000008 No Adverse Effect Open field test 6 weeks Hsiao EY , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hsiao EY , et al. (2013)
Neurophysiology - Not Reported - - Hsiao EY , et al. (2013)
Repetitive behavior AM1300007 Restored Marble-burying test 6 weeks Hsiao EY , et al. (2013)
Seizure - Not Reported - - Hsiao EY , et al. (2013)
Sensory AM1500014 Restored Prepulse inhibition 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600012 Refractory Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior AM1600014 Refractory Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)

R_POLYIC_3_IN_B

Model Source:

Harlan Laboratories

Model Type:

Induced

Strain of Origin:

Sprague Dawley

Construct Definition:

Administration of Poly(I:C) or vehicle control in pregnant rats

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Hemmerle AM , et al. (2015)
Communications - Not Reported - - Hemmerle AM , et al. (2015)
Developmental profile - Not Reported - - Hemmerle AM , et al. (2015)
Emotion - Not Reported - - Hemmerle AM , et al. (2015)
Homeostasis - Not Reported - - Hemmerle AM , et al. (2015)
Immune response - Not Reported - - Hemmerle AM , et al. (2015)
Learning & memory - Not Reported - - Hemmerle AM , et al. (2015)
Maternal behavior - Not Reported - - Hemmerle AM , et al. (2015)
Molecular profile AM900016 Decreased In situ hybridization (ISH):Anterior cingulate cortex:BDNF 2 weeks Hemmerle AM , et al. (2015)
Molecular profile AM900016 Decreased In situ hybridization (ISH):Prefrontal cortex:NRG1 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 Increased In situ hybridization (ISH):Prefrontal cortex:BDNF 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 Increased In situ hybridization (ISH):Anterior cingulate cortex, prefrontal cortex, parietal cortex:ERbB4 2 weeks, 1 month, 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 Increased In situ hybridization (ISH):Anterior cingulate cortex:BDNF 2 weeks, 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 No Change In situ hybridization (ISH):Prefrontal, Anterior Cingulate, Frontal, Parietal, Piriform cortices, Striatum, Hippocampus (CA1 and 3) and dentate gyrus:BDNF 2 weeks, 1 month, 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 No Change In situ hybridization (ISH):Prefrontal, Anterior Cingulate, Frontal, Parietal, Piriform cortices, Striatum, Hippocampus (CA1 and 3) and dentate gyrus:ErbB4 2 weeks, 1 month, 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 No Change In situ hybridization (ISH):Prefrontal, Anterior Cingulate, Frontal, Parietal, Piriform cortices, Striatum, Hippocampus (CA1 and 3) and dentate gyrus:NRG1 2 weeks, 1 month, 2 months Hemmerle AM , et al. (2015)
Molecular profile AM900016 No Change In situ hybridization (ISH):Anterior cingulate cortex:BDNF 2 weeks, 1 month, 2 months Hemmerle AM , et al. (2015)
Motor phenotype - Not Reported - - Hemmerle AM , et al. (2015)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Hemmerle AM , et al. (2015)
Neurophysiology - Not Reported - - Hemmerle AM , et al. (2015)
Repetitive behavior - Not Reported - - Hemmerle AM , et al. (2015)
Seizure - Not Reported - - Hemmerle AM , et al. (2015)
Sensory - Not Reported - - Hemmerle AM , et al. (2015)
Social behavior - Not Reported - - Hemmerle AM , et al. (2015)

POLYIC_11_IN_B

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5, the authors note that C57BL/6 mice used were of a stable immunological phenotype as they used these mice to study cytokine levels, therefore these are probably a substrain sold by Taconic. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications AM200004 Increased Monitoring ultrasonic vocalizations: manual count P7-P9 Choi GB , et al. (2016)
Developmental profile AM300002 No Change Body weight measurement 3-3.7 months Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis AM500019 No Change - 3-3.7 months Choi GB , et al. (2016)
Immune response AM600020 No Change ELISA E14.5 Choi GB , et al. (2016)
Immune response AM600019 Increased ELISA E14.5 Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile AM900016 Increased In situ hybridization (ISH) E14.5 Choi GB , et al. (2016)
Molecular profile AM900020 Decreased Immunohistochemistry E14.5, E18.5, adult Choi GB , et al. (2016)
Motor phenotype AM1000008 No Change Three-chamber social approach test: distance traveled Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100008 Decreased Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100009 No Change Immunohistochemistry E18.5 Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior AM1300007 Increased Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Decreased Three-chamber social approach test Adult Choi GB , et al. (2016)

POLYIC_11_IN_B_anti-IL17a

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pretreatment with monoclonal anti-IL17a (IL-17 a blocking antibody) at 500 microg/ animal(i.p.), 6 hrs prior to administration for PolyI:C. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications AM200004 Restored Monitoring ultrasonic vocalizations: manual count P7-P9 Choi GB , et al. (2016)
Developmental profile AM300002 No Adverse Effect Body weight measurement 3-3.7 months Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis AM500019 No Adverse Effect - - Choi GB , et al. (2016)
Immune response AM600020 No Adverse Effect ELISA E14.5 Choi GB , et al. (2016)
Immune response AM600019 Restored ELISA E14.5 Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype AM1000008 No Adverse Effect Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100008 Restored Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior AM1300007 Restored Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Restored Three-chamber social approach test Adult Choi GB , et al. (2016)

POLYIC_11_IN_B_anti-IL17a-2

Model Source:

-

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

Administration of PolyI:C on E12.5, followed by treatment with monoclonal anti-IL17a (IL-17 a blocking antibody) at 500 ug/ animal(i.p.) at E14.5. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications AM200004 Ameliorated Monitoring ultrasonic vocalizations: manual count P7-P9 Choi GB , et al. (2016)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response - Not Reported - - Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype AM1000008 No Adverse Effect Three-chamber social approach test - Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior AM1300007 Ameliorated Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Refractory Three-chamber social approach test Adult Choi GB , et al. (2016)

POLYIC_11_IN_B_IL17Ra_HM

Model Source:

-

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

Administration of PolyI:C on E12.5 in mice with interleukin 17 receptor a (IL-17Ra) homozygously knocked out. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications - Not Reported - - Choi GB , et al. (2016)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response - Not Reported - - Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype - Not Reported - - Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior - Not Reported - - Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Restored Three-chamber social approach test 3-3.5 months Choi GB , et al. (2016)

POLYIC_11_IN_B_IL17Ra_HT

Model Source:

-

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

Administration of PolyI:C on E12.5 in mice with interleukin 17 receptor a (IL-17Ra) heterozygously knocked out. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications - Not Reported - - Choi GB , et al. (2016)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response AM600019 Ameliorated ELISA: maternal sera at E14.5 E14.5 Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype - Not Reported - - Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior - Not Reported - - Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Restored Three-chamber social approach test 3-3.5 months Choi GB , et al. (2016)

POLYIC_11_IN_B_ROR_cKO

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C at E12.5 to pregnant mice with retinoic acid receptorrelated orphan nuclear receptor gamma t (RORt) conditionally knocked out specifically from CD4+ cells, homozygously. This inhibits the functions of TH17 cells (CD4+RORt+ cells) that express IL-17a and other RORt-expressing T cells, but there is no effect in RORt-expressing innate (or innate-like) immune cells, including T, lymphoid tissue-inducer (LTi) cells, and innate lym-phoid cells type 3 (ILC3). Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dam

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications AM200004 Restored Monitoring ultrasonic vocalizations: manual count P7-P9 Choi GB , et al. (2016)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response AM600019 Restored ELISA P7-P9 Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype AM1000008 No Adverse Effect - - Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100008 Restored Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior AM1300007 Restored Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Restored Three-chamber social approach test Adult Choi GB , et al. (2016)

POLYIC_11_IN_B_ROR_HT

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5 in mice with retinoic acid receptorrelated orphan nuclear receptor gamma t (RORt) heterozygously knocked out, this resulted in some levels of RORt still being present in the mothers. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications AM200004 Refractory Monitoring ultrasonic vocalizations: manual count P7-P9 Choi GB , et al. (2016)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response - Not Reported - - Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype AM1000008 No Adverse Effect Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior AM1300007 Refractory Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Refractory Three-chamber social approach test Adult Choi GB , et al. (2016)

POLYIC_6_IN_B_IL6_KO

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J (backcrossed 11 generations from B6.129S2-IL6tm1Kopf/J)

Construct Definition:

Administration of PolyI:C on E12.5 in IL6 knockout

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications - Not Reported - - Smith SE , et al. (2007)
Communications - Not Reported - - Choi GB , et al. (2016)
Developmental profile - Not Reported - - Smith SE , et al. (2007)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Emotion AM400001 Restored Open field test Adult Smith SE , et al. (2007)
Homeostasis - Not Reported - - Smith SE , et al. (2007)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response - Not Reported - - Smith SE , et al. (2007)
Immune response AM600019 Restored ELISA: maternal sera at E14.5 E14.5 Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Learning & memory AM700010 Abnormal Fear conditioning test: latent inhibition Adult Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Smith SE , et al. (2007)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Smith SE , et al. (2007)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype - Not Reported - - Choi GB , et al. (2016)
Motor phenotype AM1000009 Restored Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Smith SE , et al. (2007)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Smith SE , et al. (2007)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior - Not Reported - - Smith SE , et al. (2007)
Repetitive behavior - Not Reported - - Choi GB , et al. (2016)
Seizure - Not Reported - - Smith SE , et al. (2007)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Sensory AM1500014 Restored Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior - Not Reported - - Choi GB , et al. (2016)
Social behavior AM1600012 Restored Three-chamber social approach test Adult Smith SE , et al. (2007)

POLYIC_6_IN_B_IL6_KO_rIL17a

Model Source:

-

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

Administration of PolyI:C on E12.5 in IL6 knockout mice, at E 14.5 uterine horns of pregnant mice were exposed by a caudal ventral midlineincision (<2 cm). Recombinant mouse IL-17a cytokine (R&D) at 0.6 L of 2 ng/L was injected into the third ventricle of each embryo by a pulled micropipette, after injection of all embryos the uterus was replaced in the abdomen. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Choi GB , et al. (2016)
Communications AM200004 Increased Monitoring ultrasonic vocalizations: manual count - Choi GB , et al. (2016)
Developmental profile - Not Reported - - Choi GB , et al. (2016)
Emotion - Not Reported - - Choi GB , et al. (2016)
Homeostasis - Not Reported - - Choi GB , et al. (2016)
Immune response - Not Reported - - Choi GB , et al. (2016)
Learning & memory - Not Reported - - Choi GB , et al. (2016)
Maternal behavior - Not Reported - - Choi GB , et al. (2016)
Molecular profile - Not Reported - - Choi GB , et al. (2016)
Motor phenotype - Not Reported - - Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Choi GB , et al. (2016)
Neurophysiology - Not Reported - - Choi GB , et al. (2016)
Repetitive behavior - Not Reported - - Choi GB , et al. (2016)
Seizure - Not Reported - - Choi GB , et al. (2016)
Sensory - Not Reported - - Choi GB , et al. (2016)
Social behavior - Not Reported - - Choi GB , et al. (2016)

POLYIC_17_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

Administration of PolyI:C on E9 to pregnant mice

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Canetta S , et al. (2016)
Communications - Not Reported - - Canetta S , et al. (2016)
Developmental profile - Not Reported - - Canetta S , et al. (2016)
Emotion AM400001 Increased Elevated plus maze test Adult Canetta S , et al. (2016)
Homeostasis - Not Reported - - Canetta S , et al. (2016)
Immune response - Not Reported - - Canetta S , et al. (2016)
Learning & memory AM700001 Decreased Set-shifting task 3-3.3 months Canetta S , et al. (2016)
Learning & memory AM700016 No Change Operant conditioning paradigm; Delayed non-match to sample T-maze test 3-3.3 months Canetta S , et al. (2016)
Maternal behavior - Not Reported - - Canetta S , et al. (2016)
Molecular profile AM900031 Decreased Immunohistochemistry: GAD67 levels in prelimbic region(PrL) of the medial prefrontal cortex (mPFC) - Canetta S , et al. (2016)
Motor phenotype - Not Reported - - Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100040 No Change Stereology Adult Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100065 No Change Immunohistochemistry Adult Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture AM1100058 No Change Immunohistochemistry Adult Canetta S , et al. (2016)
Neurophysiology AM1200080 Decreased - Adult Canetta S , et al. (2016)
Neurophysiology AM1200019 Increased Whole-cell patch clamp: parvalbumin (PV) interneurons Adult Canetta S , et al. (2016)
Neurophysiology AM1200019 No Change Whole-cell patch clamp: parvalbumin (PV) interneurons Adult Canetta S , et al. (2016)
Neurophysiology AM1200026 No Change Whole-cell patch clamp: pyramidal cells in slices containing prelimbic region(PrL) of the medial prefrontal cortex(mPFC) 3-3.3 months Canetta S , et al. (2016)
Neurophysiology AM1200028 Decreased Whole-cell patch clamp: pyramidal cells in slices containing prelimbic region(PrL) of the medial prefrontal cortex(mPFC) Adult Canetta S , et al. (2016)
Neurophysiology AM1200059 Decreased Whole-cell patch clamp: pyramidal cells in slices containing prelimbic region(PrL) of the medial prefrontal cortex(mPFC) 3-3.3 months Canetta S , et al. (2016)
Neurophysiology AM1200086 Decreased Whole-cell patch clamp: pyramidal cells in slices containing prelimbic region(PrL) of the medial prefrontal cortex (mPFC) 3-3.3 months Canetta S , et al. (2016)
Repetitive behavior - Not Reported - - Canetta S , et al. (2016)
Seizure - Not Reported - - Canetta S , et al. (2016)
Sensory - Not Reported - - Canetta S , et al. (2016)
Social behavior - Not Reported - - Canetta S , et al. (2016)

POLYIC_17_IN_B_PV-ChR2

Model Source:

PMID-26830140

Model Type:

Induced

Strain of Origin:

129S6/SvEvTac * C57BL/6NCrl*129P2/OlaHsd

Construct Definition:

Administration of PolyI:C on E9 to pregnant mice with the background of parvalbumin-Cre bred to channel rhodopsin2-YFP flox stop reporter line, resulting in channel rhodopsin being expressed in the parvalbumin positive neurons. This line was used to measure the functional GABAergic connectivity between populations of prefrontal parvalbumin expressing interneurons with their post synaptic pyramidal cell targets

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - Canetta S , et al. (2016)
Communications - Not Reported - - Canetta S , et al. (2016)
Developmental profile - Not Reported - - Canetta S , et al. (2016)
Emotion - Not Reported - - Canetta S , et al. (2016)
Homeostasis - Not Reported - - Canetta S , et al. (2016)
Immune response - Not Reported - - Canetta S , et al. (2016)
Learning & memory - Not Reported - - Canetta S , et al. (2016)
Maternal behavior - Not Reported - - Canetta S , et al. (2016)
Molecular profile - Not Reported - - Canetta S , et al. (2016)
Motor phenotype - Not Reported - - Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - Canetta S , et al. (2016)
Neurophysiology AM1200049 Decreased Optogenetics; Light-evoked postsynaptic currents 3-3.3 months Canetta S , et al. (2016)
Neurophysiology AM1200072 Decreased Optogenetics; Light-evoked postsynaptic currents 3-3.3 months Canetta S , et al. (2016)
Repetitive behavior - Not Reported - - Canetta S , et al. (2016)
Seizure - Not Reported - - Canetta S , et al. (2016)
Sensory - Not Reported - - Canetta S , et al. (2016)
Social behavior - Not Reported - - Canetta S , et al. (2016)
PolyI:C Rescue Models(10 Models)
POLYIC_11_IN_B 2 Pharmaceutical anti-IL17a
POLYIC_11_IN_B 1 Genetic IL-17a knocked out
POLYIC_11_IN_B 1 Genetic IL-17a het knocked out
POLYIC_11_IN_B 1 Genetic retinoic acid receptorrelated orphan nuclear receptor gamma t (RORt) conditional knockout from T cells
POLYIC_11_IN_B 1 Genetic retinoic acid receptorrelated orphan nuclear receptor gamma t (RORt) het knockout
POLYIC_6_IN_B 1 Pharmaceutical anti-IL-6
POLYIC_6_IN_B 1 Genetic Deletion of IL6
POLYIC_7_IN_B 2 Cell transplant bone marrow cells
POLYIC_7_IN_B 1 Pharmaceutical B. fragilis NCTC 9343
POLYIC_9_IN_B 1 Pharmaceutical suramin
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