HELP     Sign In
Search

Relevance to Autism

Studies have found genetic association and rare variants in the FOXP2 gene that are identified with autism. Positive associations have been found in the Chinese Han population and mutations were identified in the Japanese population. However, several other studies have either found no genetic association or no rare genetic variation in the FOXP2 gene identified with autism. Separately, rare variations in the FMR1 gene have been identified with verbal dyspraxia.

Molecular Function

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes.

External Links

       

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Association between the FOXP2 gene and autistic disorder in Chinese population.
Autism
Positive Association
Absence of causative mutations and presence of autism-related allele in FOXP2 in Japanese autistic patients.
ASD
Negative Association
FOXP2 is not a major susceptibility gene for autism or specific language impairment.
ASD
Negative Association
Analysis of two language-related genes in autism: a case-control association study of FOXP2 and CNTNAP2.
ASD
Negative association
Association study of the CNS patterning genes and autism in Han Chinese in Taiwan.
ASD
Negative Association
No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population.
ASD
Negative Association
Mutation screening of FOXP2 in individuals diagnosed with autistic disorder.
ASD
Negative Association
Evaluation of FOXP2 as an autism susceptibility gene.
ASD
Support
A forkhead-domain gene is mutated in a severe speech and language disorder.
Speech and language disorder
Support
Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria.
CAS
Support
Epileptic encephalopathies of the Landau-Kleffner and continuous spike and waves during slow-wave sleep types: genomic dissection makes the link with autism.
Epilepsy
ADHD
Support
Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders.
ASD
Support
Language features in a mother and daughter of a chromosome 7;13 translocation involving FOXP2.
DVD
Support
Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia.
DVD
Support
Speech, prosody, and voice characteristics of a mother and daughter with a 7;13 translocation affecting FOXP2.
Highly Cited
Molecular evolution of FOXP2, a gene involved in speech and language.
Recent Recommendation
A functional genetic link between distinct developmental language disorders.
Recent Recommendation
Conservation and diversity of Foxp2 expression in muroid rodents: functional implications.
Recent Recommendation
Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2.
Recent Recommendation
FOXP2 targets show evidence of positive selection in European populations.
Recent Recommendation
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.
Recent recommendation
Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization.
CAS
Recent Recommendation
Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area X.
Recent Recommendation
Human-specific transcriptional regulation of CNS development genes by FOXP2.
Recent Recommendation
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits.
Verbal dyspraxia
Recent Recommendation
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN096R001 
 Silent 
 A570G 
 N/A 
  
  
  
 GEN096R002 
 Deletion 
 N/A 
 N/A 
  
  
  
 GEN096R003 
 Silent 
 C to T 
 N/A 
  
  
  
 GEN096R004 
 Silent 
 A to G 
 N/A 
  
  
  
 GEN096R005 
 Silent 
 G to T 
 N/A 
  
  
  
 GEN096R006 
 Silent 
 A to T 
 N/A 
  
  
  
 GEN096R007 
 Silent 
 T to A 
 N/A 
  
  
  
 GEN096R008 
 Silent 
 A to G 
 N/A 
  
  
  
 GEN096R009 
 Silent 
 T to C 
 N/A 
  
  
  
 GEN096R010 
 Silent 
 G to A 
 N/A 
  
  
  
 GEN096R011 
 Silent 
 T to G 
 N/A 
  
  
  
 GEN096R012 
 Insertion 
 N/A 
 N/A 
 Familial 
 Maternal 
  
 GEN096R013 
 Silent 
 T to C 
 N/A 
  
  
  
 GEN096R014 
 Silent 
 A to G 
 N/A 
  
  
  
 GEN096R015 
 Silent 
 C to G 
 N/A 
  
  
  
 GEN096R016 
 Silent 
 T to C 
 N/A 
  
  
  
 GEN096R017 
 Silent 
 T to G 
 N/A 
  
  
  
 GEN096R018 
 Silent 
 T to C 
 N/A 
  
  
  
 GEN096R019 
 Deletion 
 N/A 
 N/A 
 Familial 
 Maternal 
  
 GEN096R020 
 Deletion 
 N/A 
 N/A 
 Familial 
 Maternal 
 Multiplex 
 GEN096R021 
 Silent 
 C to T 
 G247G 
  
  
  
 GEN096R022 
 Silent 
 T to G 
 N/A 
  
  
  
 GEN096R023 
 Silent 
 A to G 
 Q190Q 
  
  
  
 GEN096R024 
 Substitution 
 T to G 
 N/A 
  
  
  
 GEN096R025 
 Substitution 
 C to G 
 N/A 
  
  
  
 GEN096R026 
 Substitution 
 A to G 
 N/A 
  
  
  
 GEN096R027 
 Substitution 
 G to A 
 N/A 
  
  
  
 GEN096R028 
 Substitution 
 G to A 
 N/A 
  
  
  
 GEN096R029 
 Silent 
 C to T 
 N/A 
  
  
  
 GEN096R030 
 Silent 
 T to A 
 N/A 
  
  
  
 GEN096R031 
 Silent 
 T to C 
 N/A 
  
  
  
 GEN096R032 
 Silent 
 T to G 
 N/A 
  
  
  
 GEN096R033 
 Silent 
 T to C 
 N/A 
  
  
  
 GEN096R034 
 Silent 
 C to G 
 N/A 
  
  
  
 GEN096R035 
 Missense 
 A60T 
 Q17L 
  
  
 Multiplex 
 GEN096R036 
 Nonsense 
 C to T 
 R328X 
 Familial 
 Maternal 
 Multiplex 
 GEN096R037 
 Insertion 
 N/A 
 N/A 
  
  
 Multiplex 
 GEN096R038 
 Missense 
 C to A 
 Pro to Thr 
 Unknown 
  
 Simplex 
 GEN096R039 
 Missense 
 A to G 
 Asn to Ser 
 Unknown 
  
 Simplex 
 GEN096R040 
 Missense 
 A to C 
 His to Pro 
 Familial ( 1 case); De novo (1 case) 
 Maternal (1 case) 
 Simplex 
 GEN096R041 
 Missense 
 A to T 
 Glu to Asp 
 Unknown 
  
 Simplex 
 GEN096R042 
 Insertion 
 insAGC 
 insGln 
 De novo (1 case); unknown (3 cases) 
  
 Simplex 
 GEN096R043 
 Missense 
 G>A 
 R553H 
 Familial 
 Maternal & paternal 
 Multi-generational 
 GEN096R044 
 Translocation 
  
  
 Unknown 
  
  
 GEN096R045 
 Translocation 
  
  
 Unknown 
  
  
 GEN096R046 
 Translocation 
  
  
 Familial 
 Maternal 
  
 GEN096R047 
 Substitution 
 c.1468+9T>C 
 Intron 
 Unknown 
  
 Unknown 
 GEN096R048 
 Missense 
 c.1217T>C 
 M406T 
 Unknown 
  
 Unknown 
 GEN096R049 
 Coding synonymous 
 c.1371T>C 
 I457 
 Unknown 
  
 Unknown 
 GEN096R050 
 Coding synonymous 
 c.1761G>A 
 K587 
 Unknown 
  
 Unknown 
 GEN096R051 
 Substitution 
 c.1770-33G>A 
 Intron 
 Unknown 
  
 Unknown 
 GEN096R052 
 In-frame deletion 
 c.522_524del 
 del(Q191) 
 Unknown 
  
 Unknown 
 GEN096R053 
 Missense 
 c.1789A>C 
 N597H 
 Unknown 
  
 Multiplex 
 GEN096R054 
 Frameshift insertion 
 ins(T) 
 Leu135PhefsX148 
 Familial 
 Paternal 
 Simplex 
 GEN096R055 
 Frameshift deletion 
 c.1243_1244delCA 
 Gln415Val*5 
 De novo 
  
 Simplex 
 GEN096R056 
 Missense 
 c.1321C>A 
 P441T 
 Familial 
 Maternal 
 Multiplex 

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN096C001 
 Silent 
  
 G to T 
 N/A 
 Japanese 
 Discovery 
 GEN096C002 
 Substitution 
 rs1456031 
 T to C 
 N/A 
 Chinese Han 
 Discovery 



Model Summary

Homozygous knockout mice display severe motor impairment, postnatal lethality, and reduced ultrasonic vocalizations.

External Links

AllenBrainAtlas   MGI Logo  Entrez Gene

References

Type
Title
Author, Year
Primary
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.
Additional
Generation of mice with a conditional Foxp2 null allele.
Additional
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
Additional
Foxp2 mutations impair auditory-motor association learning.

FOXP2_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Targeted disruption of exon 12 and 13 of Foxp2 gene
Allele Type: Targeted (Knock-Out)
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
ES Cell Line: Not Specified
Mutant ES Cell Line: Not specified
Model Source: Not Specified

FOXP2_2_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: Targeted disruption of exon 12 and 13 of Foxp2 gene
Allele Type: Targeted (Knock-Out)
Strain of Origin: C57BL/6
Genetic Background: C57BL/6
ES Cell Line: Not Specified
Mutant ES Cell Line: Not specified
Model Source: Not Specified

FOXP2_3_CN_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: loxP/Cre mediated deletion of exons 12-14 of Foxp2 gene on the maternal line
Allele Type: Targeted (Conditional)
Strain of Origin: C57BL/6
Genetic Background: C57BL/6 albino
ES Cell Line: Bruce-4
Mutant ES Cell Line: Not specified
Model Source: Not Specified

FOXP2_4_CN_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: loxP/Cre mediated deletion of exons 12-14 of Foxp2 gene on the maternal line
Allele Type: Targeted (Conditional)
Strain of Origin: C57BL/6
Genetic Background: C57BL/6 albino
ES Cell Line: Bruce-4
Mutant ES Cell Line: Not specified
Model Source: Not Specified

FOXP2_5_KI_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Homologous recombination mediated knock-in of T302N and N324S substitutions in exon 7 of Foxp2 gene
Allele Type: Targeted (Knock-In)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: Bruce-4
Mutant ES Cell Line: Not specified
Model Source: Not Specified

FOXP2_6_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: Targeted Cre-mediated deletion of exon 7 in one copy of Foxp2 gene
Allele Type: Targeted (Knock-Out)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: Bruce-4
Mutant ES Cell Line: Not specified
Model Source: Not Specified

FOXP2_7_R552H_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: ENU mutagenesis genrated misense substitution of an arginine to histidine in the DNA-binding domain of Foxp2
Allele Type: Mutagenesis (Substitution)
Strain of Origin: Not specified
Genetic Background: C3H/HeNHsd
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: Not specified

FOXP2_8_S321X_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: ENU mutagenesis genrated misense substitution of an arginine to histidine in the DNA-binding domain of Foxp2
Allele Type: Mutagenesis (Substitution)
Strain of Origin: Not specified
Genetic Background: C3H/HeNHsd
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: Not specified

FOXP2_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Lethality1
Increased
Description: Increased lethality; died by postnatal day 21
Exp Paradigm: General Observations
 General Observations
 P21
Size/Growth1
Decreased
Description: Decreased size/growth
Exp Paradigm: General Observations
 General Observations
 P3
Brain Morphology1
Decreased
Description: Decreased thickness of Molecular layer; Abnormal granule cell layer with ectopically placed cells; abnormal radial glial development
Exp Paradigm: Immunostaining for calbindin (Purkinje cell marker); GFAP (radial glial marker)
 Immunostaining analysis
 P17
Ultrasonic Vocalization1
Decreased
Description: Decreased Ultrasonic Vocalization; Decreased number of vocalizations; Normal duration, peak frequency, and bandwith; Reduced incidence of clicks
Exp Paradigm: Automated vocalization monitoring of mother-infant interaction followed by spectrographic analysis
 Automated vocalization monitoring of mother-infant interaction followed by spectrographic analysis
 P6-P15
General Locomotor Activity1
Decreased
Description: Decreased spontaneous locomotor activity
Exp Paradigm: Open field test
 Open field test
 
Geotaxis1
Abnormal
Description: Negative geotaxis; failure to orient up an incline plane when placed facing down plane
Exp Paradigm: Time taken for mouse to reorient itself in an upward facing position when placed facing downward a downward-facing slope
 Time taken for mouse to reorient itself in an upward facing position when placed facing downward a downward-facing slope
 P6-P15
Righting response1
Abnormal
Description: Delayed righting ability; Delayed righting ability when dropped
Exp Paradigm: Measure of time taken by animal to correct itself after being placed on it's back
 Measure of time taken by animal to correct itself after being placed on it's back
 P6-P15
Emotionality1
 No Change
 Dropped on a thick pad from a height of 30 cm
 P6-P15
Apoptosis1
 No Change
 TUNEL staining
 P17
Brain Anatomy1
 No Change
 Histological analysis
 P15-17
Huddling behavior1
 No Change
 General Observations
 P3
Nest building behavior1
 No Change
 General Observations
 P3
 Not Reported: Circadian sleep/wake cycle ,   Homeostasis ,   Immune Response ,   Learning & memory ,   Maternal behavior ,   Neurophysiology ,   Repetitive behavior ,   Seizure ,   Sensory ,  

FOXP2_2_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Size/Growth1
Decreased
Description: Decreased size/growth
Exp Paradigm: General Observations
 General Observations
 P3
Ultrasonic Vocalization1
Decreased
Description: Decreased Ultrasonic Vocalization; Decreased number of vocalizations; Normal duration, peak frequency, and bandwith; Normal incidence of clicks
Exp Paradigm: Automated vocalization monitoring of mother-infant interaction followed by spectrographic analysis
 Automated vocalization monitoring
 P6-P15
Emotionality1
 No Change
 Dropped on a thick pad from a height of 30 cm
 P6-P15
Cognitive Flexibility1
 No Change
 Morris water maze task
 3-4 months
Spatial reference memory1
 No Change
 Morris water maze task
 3-4 months
Apoptosis1
 No Change
 TUNEL staining in cerebellum
 P17
General Locomotor Activity1
 No Change
 Open field test
 
Geotaxis1
 No Change
 Time taken for mouse to reorient itself in an upward facing position when placed facing downward a downward-facing slope
 P6-P15
Righting response1
 No Change
 Measure of time taken by animal to correct itself after being placed on it's back
 P6-P15
Brain Anatomy1
 No Change
 Histological analysis
 P15-17
Shock sensitivity1
 No Change
 Paw withdrawl, running and vocalization response to shock stimulus
 3-4 months
Huddling behavior1
 No Change
 General Observations
 P3
Nest building behavior1
 No Change
 General Observations
 P3
 Not Reported: Circadian sleep/wake cycle ,   Homeostasis ,   Immune Response ,   Maternal behavior ,   Neurophysiology ,   Repetitive behavior ,   Seizure ,  

FOXP2_3_CN_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Lethality1
Increased
Description: Increased lethality; died by postnatal day 21
Exp Paradigm: General Observations
 General Observations
 P21
Size/Growth1
Decreased
Description: Reduced body weight
Exp Paradigm: General Observations
 General Observations
 Unreported
Brain Morphology1
Decreased
Description: Decreased cerebellar size and foliation; No other gross morphological abnormalities
Exp Paradigm: Histological Analysis
 Histological Analysis
 Unreported
Foxp2 protein expression1
Decreased
Description: Absence of Foxp2 protein in extracts
Exp Paradigm: Western Blotting
 Western Blotting
 E16.5
Foxp2 gene expression1
Decreased
Description: Absence of Foxp2 gene expression in striatal precursor region
Exp Paradigm: Quantitative real time RT-PCR
 Quantitative real time RT-PCR
 E16.5
Righting response1
Abnormal
Description: Impaired righting reflex
Exp Paradigm: Measure of time taken by animal to correct itself after being placed on it's back
 Measure of time taken by animal to correct itself after being placed on it's back
 Unreported
 Not Reported: Circadian sleep/wake cycle ,   Communications ,   Emotion ,   Homeostasis ,   Immune Response ,   Learning & memory ,   Maternal behavior ,   Neurophysiology ,   Repetitive behavior ,   Seizure ,   Sensory ,   Social behavior ,  

FOXP2_4_CN_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Foxp2 gene expression1
Decreased
Description: Decreased Foxp2 gene expression in striatal precursor region
Exp Paradigm: Quantitative real time RT-PCR
 Quantitative real time RT-PCR
 E16.5
Foxp2 protein expression1
Decreased
Description: Decreased Foxp2 protein expression in extracts
Exp Paradigm: Western Blotting
 Western Blotting
 E16.5
Size/Growth1
 No Change
 General Observations
 Unreported
Righting response1
 No Change
 Measure of time taken by animal to correct itself after being placed on it's back
 Unreported
Brain Morphology1
 No Change
 Histological analysis
 Unreported
 Not Reported: Circadian sleep/wake cycle ,   Communications ,   Emotion ,   Homeostasis ,   Immune Response ,   Learning & memory ,   Maternal behavior ,   Neurophysiology ,   Repetitive behavior ,   Seizure ,   Sensory ,   Social behavior ,  

FOXP2_5_KI_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Neurotransmitter Concentration1
Abnormal
Description: Decreased dopamine concentration; No change in concentrations of glutamate, serotonin, and GABA
Exp Paradigm: High performance liquid chromatography of frozen slices derived from the frontal cortex, cerebellum, caudate-putamen, nucleus accumbens and globus pallidus
 HPLC Analysis
 Unreported
Synaptic Plasticity2
Increased
Description: Increased Long Term Depression (LTD) after frequency stimulation of cortical fibers
Exp Paradigm: Whole-cell recordings of medium spiny neurons in acute tissue slice at holding potential of -70 mV
 Whole-cell recordings
 15-27 days
Total Dendrite Length1
Increased
Description: Increased dendritic tree length
Exp Paradigm: Golgi-Cox staining of three medium spiny neurons
 Golgi-Cox Staining
 12 weeks
Gene expression1
Decreased
Description: Decreased Foxp2 binding motif expression
Exp Paradigm: High density oligonucleotide array
 High density oligonucleotide array
 E16.5 - 3 months
Ultrasonic Vocalization1
 No Change
 Spectrographic analysis of recordings
 P4 - P13
Cardiovascular System1
 No Change
 Blood Pressure analysis; Electrocardiogram
 14 weeks
Developmental Trajectory1
 No Change
 X-ray analysis and bone densitometry
 16-17 weeks
Lung Function1
 No Change
 Monitoring of pressure changes
 15 weeks
Size/Growth1
 No Change
 General Observations
 
Immune Response1
 No Change
 ELISA
 12 weeks
Foxp2 protein expression1
 No Change
 Immunohistochemical analysis
 E16.5 - 3 months
Grip Strength1
 No Change
 Grip strength meter system
 10 weeks
Muscle coordination1
 No Change
 Rota-rod test
 10 weeks
Brain Anatomy1
 No Change
 General Observations
 E16.5 - 3 months
Membrane Potential1
 No Change
 Whole-cell recordings
 15-27 days
Hearing1
 No Change
 Clickbox
 6 weeks
Pain1
 No Change
 Hot-plate assay
 10 weeks
Sensorimotor gating1
 No Change
 Acoustic startle response
 Unreported
Startle Reflex1
 No Change
 Response to 110 dB white noise stimulus
 Unreported
Vision1
 No Change
 Funduscopy
 11 weeks
 Not Reported: Circadian sleep/wake cycle ,   Learning & memory ,   Maternal behavior ,   Repetitive behavior ,   Seizure ,   Social behavior ,  

FOXP2_6_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Lung Function1
Increased
Description: Increased respiratory rate
Exp Paradigm: Monitoring of pressure changes
 Monitoring of pressure changes
 15 weeks
Size/Growth1
Abnormal
Description: Abnormal metabolism: Increased fat mass, Decreased lean mass
Exp Paradigm: General Observations
 General Observations
 
Neurotransmitter Concentration1
Abnormal
Description: Increased dopamine and serotonin in nucleus accumbens concentrations; No change in concentrations of glutamate and GABA
Exp Paradigm: High performance liquid chromatography of frozen slices derived from the frontal cortex, cerebellum, caudate-putamen, nucleus accumbens and globus pallidus
 HPLC Analysis
 Unreported
Synaptic Plasticity2
Increased
Description: Increased Long Term Depression (LTD) after frequency stimulation of cortical fibers
Exp Paradigm: Whole-cell recordings of medium spiny neurons in acute tissue slice at holding potential of -70 mV
 Whole-cell recordings
 15-27 days
Total Dendrite Length1
Increased
Description: Increased dendritic tree length
Exp Paradigm: Golgi-Cox staining of three medium spiny neurons
 Golgi-Cox Staining
 12 weeks
Gene expression1
Decreased
Description: Decreased Foxp2 binding motif expression
Exp Paradigm: High density oligonucleotide array
 High density oligonucleotide array
 E16.5 - 3 months
Muscle coordination1
Decreased
Description: Decreased motor learning
Exp Paradigm: Rota-rod test
 Rota-rod test
 10 weeks
Cardiovascular System1
 No Change
 Blood Pressure analysis; Electrocardiogram
 14 weeks
Developmental Trajectory1
 No Change
 X-ray analysis and bone densitometry
 16-17 weeks
Immune Response1
 No Change
 ELISA
 12 weeks
Foxp2 protein expression1
 No Change
 Immunohistochemical analysis
 E16.5 - 3 months
Grip Strength1
 No Change
 Grip strength meter system
 10 weeks
Brain Anatomy1
 No Change
 General Observations
 E16.5 - 3 months
Membrane Potential1
 No Change
 Whole-cell recordings
 15-27 days
Hearing1
 No Change
 Clickbox
 6 weeks
Pain1
 No Change
 Hot-plate assay
 10 weeks
Sensorimotor gating1
 No Change
 Acoustic startle response
 
Startle Reflex1
 No Change
 Response to 110 dB white noise stimulus
 
Vision1
 No Change
 Funduscopy
 11 weeks
 Not Reported: Circadian sleep/wake cycle ,   Communications ,   Learning & memory ,   Maternal behavior ,   Repetitive behavior ,   Seizure ,   Social behavior ,  

FOXP2_7_R552H_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Procedural Learning1
Decreased
Description: Decreased procedural learning indicated by lower rate of spontaneous hurdle crossing
Exp Paradigm: Conditioned avoidance paradigm in a shuttle-box
 Modified shuttle box text
 8 weeks
 Not Reported: Circadian sleep/wake cycle ,   Communications ,   Developmental profile ,   Emotion ,   Homeostasis ,   Immune Response ,   Maternal behavior ,   Molecular profile ,   Motor phenotype ,   Neuroanatomy / Ultrastructure / Cytoarchitecture ,   Neurophysiology ,   Repetitive behavior ,   Seizure ,   Sensory ,   Social behavior ,  

FOXP2_8_S321X_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Procedural Learning1
Decreased
Description: Decreased procedural learning indicated by lower rate of spontaneous hurdle crossing
Exp Paradigm: Conditioned avoidance paradigm in a shuttle-box
 Modified shuttle box text
 8 weeks
 Not Reported: Circadian sleep/wake cycle ,   Communications ,   Developmental profile ,   Emotion ,   Homeostasis ,   Immune Response ,   Maternal behavior ,   Molecular profile ,   Motor phenotype ,   Neuroanatomy / Ultrastructure / Cytoarchitecture ,   Neurophysiology ,   Repetitive behavior ,   Seizure ,   Sensory ,   Social behavior ,  



Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
CNTNAP2 contactin associated protein-like 2 26047 Q9UHC6 Vernes SC 2008
FMR1 fragile X mental retardation 1 2332 G8JLE9 PAR-CLIP (HEK293 cells)
RNA-IP (HEK293 cells)
Ascano M Jr 2012
MET met proto-oncogene (hepatocyte growth factor receptor) 4233 P08581 ChIP (NHNP cells)
EMSA (SH-SY5Y cells)
WB (NHNP cells)
WB (SH-SY5Y cells)
Mukamel Z 2011
PAX6 paired box 6 5080 P26367 cannot access article
ChIP
zebrafish reporter transgenic studies
Coutinho P 2011
PLAUR plasminogen activator, urokinase receptor 5329 Q03405 EMSA (HEK293T cells)
luciferase reporter assays (HEK293T cells)
qRT-PCR (HEK293T cells)
Roll P 2010
SRPX2 sushi-repeat containing protein, X-linked 2 27286 O60687 EMSA (HEK293T cells)
luciferase reporter assays (HEK293T cells)
qRT-PCR (HEK293T cells)
Roll P 2010
0610006I08RIK transmembrane protein 223 66836 Q9CQE2 ChIP (mouse brain)
Vernes SC 2011
1110064P04RIK AHA1, activator of heat shock protein ATPase homolog 2 (yeast) 268390 Q8N9S3 ChIP (mouse brain)
Vernes SC 2011
1200013P24RIK N-acetyltransferase 15 (GCN5-related, putative) 74763 Q9DBU2 ChIP (mouse brain)
Vernes SC 2011
1300010M03RIK family with sequence similarity 134, member C 67998 Q9CQV4 ChIP (mouse brain)
Vernes SC 2011
1700009P03RIK RNA binding motif protein 26 74213 Q6NZN0 ChIP (mouse brain)
Vernes SC 2011
1700054O13RIK RIKEN cDNA 1700054O13 gene 67334 A2AF56 ChIP (mouse brain)
Vernes SC 2011
1810011O10RIK RIKEN cDNA 1810011O10 gene 69068 Q9D915 ChIP (mouse brain)
Vernes SC 2011
1810037C20RIK family with sequence similarity 3, member A 66294 Q9D8T0 ChIP (mouse brain)
Vernes SC 2011
2010321M09RIK RIKEN cDNA 2010321M09 gene 69882 Q8R3P6 ChIP (mouse brain)
Vernes SC 2011
2200002K05RIK RIKEN cDNA 2200002K05 gene 69137 Q9D806 ChIP (mouse brain)
Vernes SC 2011
2310028H24RIK RIKEN cDNA 2310028H24 gene 71901 N/A ChIP (mouse brain)
Vernes SC 2011
2310057M21RIK RIKEN cDNA 2310057M21 gene 68277 Q9D2Q3 ChIP (mouse brain)
Vernes SC 2011
2310061I09RIK coiled-coil domain containing 115 69668 Q8VE99 ChIP (mouse brain)
Vernes SC 2011
2510048L02RIK coiled-coil domain containing 159 67119 Q8C963 ChIP (mouse brain)
Vernes SC 2011
2810002I04RIK family with sequence similarity 164, member C 72350 Q8CCG1 ChIP (mouse brain)
Vernes SC 2011
2810430M08RIK ribosomal RNA processing 15 homolog (S. cerevisiae) 67223 Q9CYX7 ChIP (mouse brain)
Vernes SC 2011
2900041A09RIK tubulin polymerization promoting protein 72948 Q7TQD2 ChIP (mouse brain)
Vernes SC 2011
3110043J09RIK Rho GTPase activating protein 8 73167 Q9CXP4 ChIP (mouse brain)
Vernes SC 2011
3200002M19RIK RIKEN cDNA 3200002M19 gene 75430 P60007 ChIP (mouse brain)
Vernes SC 2011
4632428N05RIK RIKEN cDNA 4632428N05 gene 74048 E9PUF5 ChIP (mouse brain)
Vernes SC 2011
4930408O21RIK PDZ domain containing 9 67983 Q9D9M4 ChIP (mouse brain)
Vernes SC 2011
4933403G14RIK RIKEN cDNA 4933403G14 gene 74393 Q8BJS7 ChIP (mouse brain)
Vernes SC 2011
8430419L09RIK RIKEN cDNA 8430419L09 gene 74525 Q8BYI8 ChIP (mouse brain)
Vernes SC 2011
9230117E20RIK serine peptidase inhibitor, Kazal type 11 78242 Q9D256 ChIP (mouse brain)
Vernes SC 2011
A130033B22 predicted gene 5094 328839 N/A ChIP (mouse brain)
Vernes SC 2011
A530082C11RIK solute carrier family 35, member E2 320541 Q8C811 ChIP (mouse brain)
Vernes SC 2011
A730085E03RIK RIKEN cDNA A730085E03 gene 328983 N/A ChIP (mouse brain)
Vernes SC 2011
A930001M12RIK transmembrane protein 215 320500 A7E1Z1 ChIP (mouse brain)
Vernes SC 2011
AARD alanine and arginine rich domain containing protein 239435 Q811W1 ChIP (mouse brain)
Vernes SC 2011
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 76184 Q8K441 ChIP (mouse brain)
Vernes SC 2011
ACYP1 acylphosphatase 1, erythrocyte (common) type 66204 P56376 ChIP (mouse brain)
Vernes SC 2011
ALKBH5 alkB, alkylation repair homolog 5 (E. coli) 268420 Q3TSG4 ChIP (mouse brain)
Vernes SC 2011
ALOX12E arachidonate lipoxygenase, epidermal 11685 P55249 ChIP (mouse brain)
Vernes SC 2011
ARL11 ADP-ribosylation factor-like 11 219144 Q6P3A9 ChIP (mouse brain)
Vernes SC 2011
ARPM1 actin related protein M1 76652 Q8BXF8 ChIP (mouse brain)
Vernes SC 2011
ARRDC2 arrestin domain containing 2 70807 Q9D668 ChIP (mouse brain)
Vernes SC 2011
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 11931 P14094 ChIP (mouse brain)
Vernes SC 2011
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 11946 Q03265 ChIP (mouse brain)
Vernes SC 2011
BARD1 BRCA1 associated RING domain 1 12021 O70445 ChIP (mouse brain)
Vernes SC 2011
BATF2 basic leucine zipper transcription factor, ATF-like 2 74481 Q8R1H8 ChIP (mouse brain)
Vernes SC 2011
BC019537 solute carrier family 17, member 9 228993 Q8VCL5 ChIP (mouse brain)
Vernes SC 2011
BC021442 zinc finger protein 758 224598 E9Q462 ChIP (mouse brain)
Vernes SC 2011
BC035954 cDNA sequence BC035954 194162 N/A ChIP (mouse brain)
Vernes SC 2011
BC050188 tripartite motif family-like 1 244448 Q8BVP1 ChIP (mouse brain)
Vernes SC 2011
BET1 blocked early in transport 1 homolog (S. cerevisiae) 12068 O35623 ChIP (mouse brain)
Vernes SC 2011
BLMH bleomycin hydrolase 104184 Q8R016 ChIP (mouse brain)
Vernes SC 2011
C78339 expressed sequence C78339 97863 Q3URQ4 ChIP (mouse brain)
Vernes SC 2011
CACNA2D1 calcium channel, voltage-dependent, alpha2/delta subunit 1 12293 O08532 ChIP (mouse brain)
Vernes SC 2011
CATSPER3 cation channel, sperm associated 3 76856 Q80W99 ChIP (mouse brain)
Vernes SC 2011
CBLN2 cerebellin 2 precursor protein 12405 Q8BGU2 ChIP (mouse brain)
Vernes SC 2011
CCDC80 coiled-coil domain containing 80 67896 Q8R2G6 ChIP (mouse brain)
Vernes SC 2011
CCNL2 cyclin L2 56036 Q9JJA7 ChIP (mouse brain)
Vernes SC 2011
CD53 CD53 antigen 12508 Q61451 ChIP (mouse brain)
Vernes SC 2011
CD59A CD59a antigen 12509 O55186 ChIP (mouse brain)
Vernes SC 2011
CDC2L6 cyclin-dependent kinase 19 78334 Q8BWD8 ChIP (mouse brain)
Vernes SC 2011
CDK8 cyclin-dependent kinase 8 264064 Q8R3L8 ChIP (mouse brain)
Vernes SC 2011
CDYL2 chromodomain protein, Y chromosome-like 2 75796 Q9D5D8 ChIP (mouse brain)
Vernes SC 2011
CES2 carboxylesterase 2C 234671 Q91WG0 ChIP (mouse brain)
Vernes SC 2011
CGA glycoprotein hormones, alpha subunit 12640 P01216 ChIP (mouse brain)
Vernes SC 2011
CHRNA1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) 11435 P04756 ChIP (mouse brain)
Vernes SC 2011
CLASP2 CLIP associating protein 2 76499 Q8BRT1 ChIP (mouse brain)
Vernes SC 2011
CLCN1 chloride channel 1 12723 Q64347 ChIP (mouse brain)
Vernes SC 2011
COBL cordon-bleu 12808 Q5NBX1 ChIP (mouse brain)
Vernes SC 2011
COL24A1 collagen, type XXIV, alpha 1 71355 Q30D77 ChIP (mouse brain)
Vernes SC 2011
COL3A1 collagen, type III, alpha 1 12825 P08121 ChIP (mouse brain)
Vernes SC 2011
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3 228410 Q99LI7 ChIP (mouse brain)
Vernes SC 2011
CTBP1 C-terminal binding protein 1 13016 O88712 IP/WB (HEK293 cells)
luciferase reporter assay (H441 cells)
luciferase reporter assay (NIH-3T3 cells)
Y2H
Li S 2004
CTRB1 chymotrypsinogen B1 66473 Q9CR35 ChIP (mouse brain)
Vernes SC 2011
CUL1 cullin 1 26965 Q9WTX6 ChIP (mouse brain)
Vernes SC 2011
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 244672 Q8BG79 ChIP (mouse brain)
Vernes SC 2011
CYCS cytochrome c, somatic 13063 P62897 ChIP (mouse brain)
Vernes SC 2011
CYR61 cysteine rich protein 61 16007 P18406 ChIP (mouse brain)
Vernes SC 2011
D030041N04RIK leucine zipper-EF-hand containing transmembrane protein 2 270035 Q7TNU7 ChIP (mouse brain)
Vernes SC 2011
D11ERTD730E SLU7 splicing factor homolog (S. cerevisiae) 193116 Q8BHJ9 ChIP (mouse brain)
Vernes SC 2011
D330045A20RIK RIKEN cDNA D330045A20 gene 102871 N/A ChIP (mouse brain)
Vernes SC 2011
D830007B15RIK shisa homolog 3 (Xenopus laevis) 330096 Q3UPR0 ChIP (mouse brain)
Vernes SC 2011
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 78394 Q3TKX4 ChIP (mouse brain)
Vernes SC 2011
DMBT1 deleted in malignant brain tumors 1 12945 Q60997 ChIP (mouse brain)
Vernes SC 2011
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 76594 Q9CZJ9 ChIP (mouse brain)
Vernes SC 2011
DOCK8 dedicator of cytokinesis 8 76088 Q8C147 ChIP (mouse brain)
Vernes SC 2011
DSPG3 epiphycan 13516 P70186 ChIP (mouse brain)
Vernes SC 2011
DTNA dystrobrevin alpha 13527 Q9D2N4 ChIP (mouse brain)
Vernes SC 2011
DTNB dystrobrevin, beta 13528 O70585 ChIP (mouse brain)
Vernes SC 2011
ECHDC1 enoyl Coenzyme A hydratase domain containing 1 52665 Q9D9V3 ChIP (mouse brain)
Vernes SC 2011
EDA2R ectodysplasin A2 receptor 245527 Q8BX35 ChIP (mouse brain)
Vernes SC 2011
EDNRA endothelin receptor type A 13617 Q61614 ChIP (mouse brain)
Vernes SC 2011
EIF3S10 eukaryotic translation initiation factor 3, subunit A 13669 P23116 ChIP (mouse brain)
Vernes SC 2011
ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 15572 Q61701 ChIP (mouse brain)
Vernes SC 2011
ELK3 ELK3, member of ETS oncogene family 13713 P41971 ChIP (mouse brain)
Vernes SC 2011
ELP3 elongation protein 3 homolog (S. cerevisiae) 74195 Q9CZX0 ChIP (mouse brain)
Vernes SC 2011
EMX2 empty spiracles homolog 2 (Drosophila) 13797 Q04744 ChIP (mouse brain)
Vernes SC 2011
EPC1 enhancer of polycomb homolog 1 (Drosophila) 13831 Q8C9X6 ChIP (mouse brain)
Vernes SC 2011
ETV1 ets variant gene 1 14009 P41164 ChIP (mouse brain)
Vernes SC 2011
EZH2 enhancer of zeste homolog 2 (Drosophila) 14056 Q61188 ChIP (mouse brain)
Vernes SC 2011
FBXL4 F-box and leucine-rich repeat protein 4 269514 Q8BH70 ChIP (mouse brain)
Vernes SC 2011
FGF1 fibroblast growth factor 1 14164 P61148 ChIP (mouse brain)
Vernes SC 2011
FMO2 flavin containing monooxygenase 2 55990 Q8K2I3 ChIP (mouse brain)
Vernes SC 2011
FNBP1L formin binding protein 1-like 214459 Q8K012 ChIP (mouse brain)
Vernes SC 2011
FOXP1 forkhead box P1 108655 P58462 IP/WB (HEK293 cells)
Li S 2004
FOXP2 forkhead box P2 114142 P58463 IP/WB (HEK293 cells)
Li S 2004
FOXP4 forkhead box P4 74123 Q9DBY0 IP/WB (HEK293 cells)
Li S 2004
FUT8 fucosyltransferase 8 53618 Q9WTS2 ChIP (mouse brain)
Vernes SC 2011
FXYD2 FXYD domain-containing ion transport regulator 2 11936 Q04646 ChIP (mouse brain)
Vernes SC 2011
GALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 78752 Q8C1F4 ChIP (mouse brain)
Vernes SC 2011
GATA6 GATA binding protein 6 14465 Q61169 ChIP (mouse brain)
Vernes SC 2011
GATAD2B GATA zinc finger domain containing 2B 57459 Q8WXI9 GST (purified proteins)
IP/WB (HEK293 cells)
Y2H
Chokas AL 2010
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 66569 Q9CRY7 ChIP (mouse brain)
Vernes SC 2011
GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 106039 Q8R0H9 ChIP (mouse brain)
Vernes SC 2011
GGN gametogenetin 243897 Q80WJ1 ChIP (mouse brain)
Vernes SC 2011
GM1553 predicted gene 1553 432480 Q66VB7 ChIP (mouse brain)
Vernes SC 2011
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 14677 B2RSH2 ChIP (mouse brain)
Vernes SC 2011
GPM6A glycoprotein m6a 234267 P35802 ChIP (mouse brain)
Vernes SC 2011
HIST1H2AB histone cluster 1, H2ab 319172 P22752 ChIP (mouse brain)
Vernes SC 2011
HIST1H4H histone cluster 1, H4h 69386 P62806 ChIP (mouse brain)
Vernes SC 2011
HIST2H2BE histone cluster 2, H2be 319190 Q64524 ChIP (mouse brain)
Vernes SC 2011
HIST2H3C1 histone cluster 2, H3c1 15077 P84228 ChIP (mouse brain)
Vernes SC 2011
HRSP12 heat-responsive protein 12 15473 P52760 ChIP (mouse brain)
Vernes SC 2011
HYOU1 hypoxia up-regulated 1 12282 Q9JKR6 ChIP (mouse brain)
Vernes SC 2011
IL12B interleukin 12b 16160 P43432 ChIP (mouse brain)
Vernes SC 2011
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 320563 Q5RKR3 ChIP (mouse brain)
Vernes SC 2011
JPH4 junctophilin 4 319984 Q80WT0 ChIP (mouse brain)
Vernes SC 2011
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 210973 Q6ZPP6 ChIP (mouse brain)
Vernes SC 2011
KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4 16492 Q61423 ChIP (mouse brain)
Vernes SC 2011
KCTD4 potassium channel tetramerisation domain containing 4 67516 Q9D7X1 ChIP (mouse brain)
Vernes SC 2011
KEL Kell blood group 23925 Q9EQF2 ChIP (mouse brain)
Vernes SC 2011
KIF20A kinesin family member 20A 19348 P97329 ChIP (mouse brain)
Vernes SC 2011
KLF6 Kruppel-like factor 6 23849 Q8BPQ2 ChIP (mouse brain)
Vernes SC 2011
KLRE1 killer cell lectin-like receptor family E member 1 243655 Q8CJC7 ChIP (mouse brain)
Vernes SC 2011
LDHB lactate dehydrogenase B 16832 P16125 ChIP (mouse brain)
Vernes SC 2011
LIPC lipase, hepatic 15450 P27656 ChIP (mouse brain)
Vernes SC 2011
LOC433178 serine peptidase inhibitor, Kazal type 14 433178 B9EJP9 ChIP (mouse brain)
Vernes SC 2011
LOH12CR1 loss of heterozygosity, 12, chromosomal region 1 homolog (human) 67774 Q9D920 ChIP (mouse brain)
Vernes SC 2011
MAFK v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) 17135 Q61827 ChIP (mouse brain)
Vernes SC 2011
MAGEE1 melanoma antigen, family E, 1 107528 Q6PCZ4 ChIP (mouse brain)
Vernes SC 2011
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 17149 P61327 ChIP (mouse brain)
Vernes SC 2011
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 240354 Q2TBA3 ChIP (mouse brain)
Vernes SC 2011
MANSC1 MANSC domain containing 1 67729 Q9CR33 ChIP (mouse brain)
Vernes SC 2011
MAPKAPK2 MAP kinase-activated protein kinase 2 17164 P49138 ChIP (mouse brain)
Vernes SC 2011
MATR3 matrin 3 17184 Q8K310 ChIP (mouse brain)
Vernes SC 2011
MCPH1 microcephaly, primary autosomal recessive 1 244329 Q7TT79 ChIP (mouse brain)
Vernes SC 2011
MKS1 Meckel syndrome, type 1 380718 Q5SW45 ChIP (mouse brain)
Vernes SC 2011
MMU-LET-7A-1 microRNA let7a-1 387244 N/A ChIP (mouse brain)
Vernes SC 2011
MMU-MIR-137 microRNA 137 387155 N/A ChIP (mouse brain)
Vernes SC 2011
MMU-MIR-19B-1 microRNA 19b-2 387195 N/A ChIP (mouse brain)
Vernes SC 2011
MMU-MIR-469 microRNA 469 723872 N/A ChIP (mouse brain)
Vernes SC 2011
MTERF mitochondrial transcription termination factor 545725 Q8CHZ9 ChIP (mouse brain)
Vernes SC 2011
MYNN myoneurin 80732 Q99MD8 ChIP (mouse brain)
Vernes SC 2011
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 72560 Q9CZR2 ChIP (mouse brain)
Vernes SC 2011
NEUROD6 neurogenic differentiation 6 11922 P48986 ChIP (mouse brain)
Vernes SC 2011
NFAT5 nuclear factor of activated T-cells 5 54446 Q9WV30 ChIP (mouse brain)
Vernes SC 2011
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 217365 P60670 ChIP (mouse brain)
Vernes SC 2011
NPTN neuroplastin 20320 P97300 ChIP (mouse brain)
Vernes SC 2011
NPY6R neuropeptide Y receptor Y6 18169 Q61212 ChIP (mouse brain)
Vernes SC 2011
NRN1 neuritin 1 68404 Q8CFV4 ChIP (mouse brain)
Vernes SC 2011
NSG1 neuron specific gene family member 1 18196 Q62092 ChIP (mouse brain)
Vernes SC 2011
OC90 otoconin 90 18256 Q9Z0L3 ChIP (mouse brain)
Vernes SC 2011
OLFR113 olfactory receptor 113 258286 Q8VEU4 ChIP (mouse brain)
Vernes SC 2011
OLFR1184 olfactory receptor 1184 258820 Q8VG86 ChIP (mouse brain)
Vernes SC 2011
OLFR131 olfactory receptor 131 258867 Q8VGC8 ChIP (mouse brain)
Vernes SC 2011
OLFR1388 olfactory receptor 1388 258459 Q8VFA3 ChIP (mouse brain)
Vernes SC 2011
OLFR139 olfactory receptor 139 259005 Q60891 ChIP (mouse brain)
Vernes SC 2011
OLFR1465 olfactory receptor 1465 258121 Q7TQR2 ChIP (mouse brain)
Vernes SC 2011
OLFR26 olfactory receptor 26 18324 Q7TRB7 ChIP (mouse brain)
Vernes SC 2011
OLFR284 olfactory receptor 284 258278 Q8VET7 ChIP (mouse brain)
Vernes SC 2011
OLFR305 olfactory receptor 305 258609 Q7TS02 ChIP (mouse brain)
Vernes SC 2011
OLFR461 olfactory receptor 461 258380 N/A ChIP (mouse brain)
Vernes SC 2011
OLFR487 olfactory receptor 487 258042 Q7TRU9 ChIP (mouse brain)
Vernes SC 2011
OLFR711 olfactory receptor 711 259037 Q9EPG2 ChIP (mouse brain)
Vernes SC 2011
OLFR723 olfactory receptor 723 259147 E9PZU2 ChIP (mouse brain)
Vernes SC 2011
OLFR978 olfactory receptor 978 259109 E9Q985 ChIP (mouse brain)
Vernes SC 2011
ORC6L origin recognition complex, subunit 6 56452 Q9WUJ8 ChIP (mouse brain)
Vernes SC 2011
PACS1 phosphofurin acidic cluster sorting protein 1 107975 Q8K212 ChIP (mouse brain)
Vernes SC 2011
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 18481 Q61036 ChIP (mouse brain)
Vernes SC 2011
PAQR5 progestin and adipoQ receptor family member V 74090 Q9DCU0 ChIP (mouse brain)
Vernes SC 2011
PBEF1 nicotinamide phosphoribosyltransferase 59027 Q99KQ4 ChIP (mouse brain)
Vernes SC 2011
PCDH20 protocadherin 20 219257 Q8BIZ0 ChIP (mouse brain)
Vernes SC 2011
PCDHA2 protocadherin alpha 2 353234 N/A ChIP (mouse brain)
Vernes SC 2011
PCOLN3 chromatin modifying protein 1A 234852 Q921W0 ChIP (mouse brain)
Vernes SC 2011
PDCD10 programmed cell death 10 56426 Q8VE70 ChIP (mouse brain)
Vernes SC 2011
PDHX pyruvate dehydrogenase complex, component X 27402 Q8BKZ9 ChIP (mouse brain)
Vernes SC 2011
PGAM5 phosphoglycerate mutase family member 5 72542 Q8BX10 ChIP (mouse brain)
Vernes SC 2011
PI16 peptidase inhibitor 16 74116 Q9ET66 ChIP (mouse brain)
Vernes SC 2011
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 18700 Q64323 ChIP (mouse brain)
Vernes SC 2011
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 67292 Q9CXR4 ChIP (mouse brain)
Vernes SC 2011
PIK3R1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 18708 P26450 ChIP (mouse brain)
Vernes SC 2011
PKDREJ polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin) 18766 Q9Z0T6 ChIP (mouse brain)
Vernes SC 2011
PLA2G10 phospholipase A2, group X 26565 Q9QXX3 ChIP (mouse brain)
Vernes SC 2011
PLAG1 pleiomorphic adenoma gene 1 56711 Q9QYE0 ChIP (mouse brain)
Vernes SC 2011
PLK2 polo-like kinase 2 (Drosophila) 20620 P53351 ChIP (mouse brain)
Vernes SC 2011
PNRC2 proline-rich nuclear receptor coactivator 2 52830 Q9CR73 ChIP (mouse brain)
Vernes SC 2011
PON2 paraoxonase 2 330260 Q62086 ChIP (mouse brain)
Vernes SC 2011
POT1 protection of telomeres 1 homolog (S. pombe) 25913 Q9NUX5 IP/WB (COS cells)
Y2H
Tanabe Y 2011
POU2F1 POU domain, class 2, transcription factor 1 18986 P25425 ChIP (mouse brain)
Vernes SC 2011
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 67418 Q9CXG3 ChIP (mouse brain)
Vernes SC 2011
PRCP prolylcarboxypeptidase (angiotensinase C) 72461 Q7TMR0 ChIP (mouse brain)
Vernes SC 2011
PRLPM prolactin family 2, subfamily a, member 1 56635 Q9JHK0 ChIP (mouse brain)
Vernes SC 2011
PRMT4 coactivator-associated arginine methyltransferase 1 59035 Q9WVG6 ChIP (mouse brain)
Vernes SC 2011
PRR3 proline-rich polypeptide 3 75210 Q811B5 ChIP (mouse brain)
Vernes SC 2011
PRSS2 protease, serine, 2 22072 P07146 ChIP (mouse brain)
Vernes SC 2011
PSMA3 proteasome (prosome, macropain) subunit, alpha type 3 19167 O70435 ChIP (mouse brain)
Vernes SC 2011
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 66413 Q99JI4 ChIP (mouse brain)
Vernes SC 2011
PSTK phosphoseryl-tRNA kinase 214580 Q8BP74 ChIP (mouse brain)
Vernes SC 2011
PTTG1 pituitary tumor-transforming gene 1 30939 Q9CQJ7 ChIP (mouse brain)
Vernes SC 2011
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 106248 B8ZXI1 ChIP (mouse brain)
Vernes SC 2011
RAB30 RAB30, member RAS oncogene family 75985 Q923S9 ChIP (mouse brain)
Vernes SC 2011
RAB3C RAB3C, member RAS oncogene family 67295 P62823 ChIP (mouse brain)
Vernes SC 2011
RAB9B RAB9B, member RAS oncogene family 319642 Q8BHH2 ChIP (mouse brain)
Vernes SC 2011
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 268859 Q9JJ43 ChIP (mouse brain)
Vernes SC 2011
RBM7 RNA binding motif protein 7 67010 Q9CQT2 ChIP (mouse brain)
Vernes SC 2011
RHOJ ras homolog gene family, member J 80837 Q9ER71 ChIP (mouse brain)
Vernes SC 2011
RHOT2 ras homolog gene family, member T2 214952 Q8JZN7 ChIP (mouse brain)
Vernes SC 2011
RLN1 relaxin 1 19773 N/A ChIP (mouse brain)
Vernes SC 2011
RNF17 ring finger protein 17 30054 Q99MV7 ChIP (mouse brain)
Vernes SC 2011
ROBO4 roundabout homolog 4 (Drosophila) 74144 Q8C310 ChIP (mouse brain)
Vernes SC 2011
RPA3 replication protein A3 68240 Q9CQ71 ChIP (mouse brain)
Vernes SC 2011
SCN2B sodium channel, voltage-gated, type II, beta 72821 Q56A07 ChIP (mouse brain)
Vernes SC 2011
SDCCAG1 nuclear export mediator factor 66244 Q8CCP0 ChIP (mouse brain)
Vernes SC 2011
SEMA4F sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain 20355 Q9Z123 ChIP (mouse brain)
Vernes SC 2011
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 214968 Q76KF0 ChIP (mouse brain)
Vernes SC 2011
SF1 splicing factor 1 22668 Q64213 ChIP (mouse brain)
Vernes SC 2011
SIRT5 sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) 68346 Q8K2C6 ChIP (mouse brain)
Vernes SC 2011
SLC12A2 solute carrier family 12, member 2 20496 P55012 ChIP (mouse brain)
Vernes SC 2011
SLC12A9 solute carrier family 12 (potassium/chloride transporters), member 9 83704 Q99MR3 ChIP (mouse brain)
Vernes SC 2011
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 114644 Q91Y63 ChIP (mouse brain)
Vernes SC 2011
SLC14A1 solute carrier family 14 (urea transporter), member 1 108052 Q8VHL0 ChIP (mouse brain)
Vernes SC 2011
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 18399 Q8VC69 ChIP (mouse brain)
Vernes SC 2011
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 214111 Q91WD8 ChIP (mouse brain)
Vernes SC 2011
SLC25A36 solute carrier family 25, member 36 192287 Q922G0 ChIP (mouse brain)
Vernes SC 2011
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 20534 N/A ChIP (mouse brain)
Vernes SC 2011
SLC4A3 solute carrier family 4 (anion exchanger), member 3 20536 P16283 ChIP (mouse brain)
Vernes SC 2011
SMC5L1 structural maintenance of chromosomes 5 226026 Q8CG46 ChIP (mouse brain)
Vernes SC 2011
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 75788 Q9CUN6 ChIP (mouse brain)
Vernes SC 2011
SPATA17 spermatogenesis associated 17 74717 Q9D552 ChIP (mouse brain)
Vernes SC 2011
SPESP1 sperm equatorial segment protein 1 66712 Q9D5A0 ChIP (mouse brain)
Vernes SC 2011
SRI sorcin 109552 Q6P069 ChIP (mouse brain)
Vernes SC 2011
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 54613 Q8VIB3 ChIP (mouse brain)
Vernes SC 2011
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 20844 P70297 ChIP (mouse brain)
Vernes SC 2011
STARD4 StAR-related lipid transfer (START) domain containing 4 170459 Q99JV5 ChIP (mouse brain)
Vernes SC 2011
STEAP1 six transmembrane epithelial antigen of the prostate 1 70358 Q9CWR7 ChIP (mouse brain)
Vernes SC 2011
SV2A synaptic vesicle glycoprotein 2 a 64051 Q9JIS5 ChIP (mouse brain)
Vernes SC 2011
SVS1 seminal vesicle secretory protein 1 243377 N/A ChIP (mouse brain)
Vernes SC 2011
SYTL5 synaptotagmin-like 5 236643 Q80T23 ChIP (mouse brain)
Vernes SC 2011
TAAR5 trace amine-associated receptor 5 215854 Q5QD14 ChIP (mouse brain)
Vernes SC 2011
TANK TRAF family member-associated Nf-kappa B activator 21353 P70347 ChIP (mouse brain)
Vernes SC 2011
TBC1D19 TBC1 domain family, member 19 67249 Q8VDV7 ChIP (mouse brain)
Vernes SC 2011
TCFAP2D transcription factor AP-2, delta 226896 Q91ZK0 ChIP (mouse brain)
Vernes SC 2011
TCTE1 t-complex-associated testis expressed 1 21645 A6H639 ChIP (mouse brain)
Vernes SC 2011
TDP1 tyrosyl-DNA phosphodiesterase 1 104884 Q8BJ37 ChIP (mouse brain)
Vernes SC 2011
TDRD3 tudor domain containing 3 219249 Q91W18 ChIP (mouse brain)
Vernes SC 2011
TMBIM4 transmembrane BAX inhibitor motif containing 4 68212 Q9DA39 ChIP (mouse brain)
Vernes SC 2011
TMEM38B transmembrane protein 38B 52076 Q9DAV9 ChIP (mouse brain)
Vernes SC 2011
TMEM55A transmembrane protein 55A 72519 Q9CZX7 ChIP (mouse brain)
Vernes SC 2011
TRAF3IP3 TRAF3 interacting protein 3 215243 Q8C0G2 ChIP (mouse brain)
Vernes SC 2011
TSPAN10 tetraspanin 10 208634 Q8VCF5 ChIP (mouse brain)
Vernes SC 2011
TSPAN13 tetraspanin 13 66109 Q9D8C2 ChIP (mouse brain)
Vernes SC 2011
UBL7 ubiquitin-like 7 (bone marrow stromal cell-derived) 69459 Q91W67 ChIP (mouse brain)
Vernes SC 2011
UMPS uridine monophosphate synthetase 22247 P13439 ChIP (mouse brain)
Vernes SC 2011
UNC50 unc-50 homolog (C. elegans) 67387 Q9CQ61 ChIP (mouse brain)
Vernes SC 2011
USPL1 ubiquitin specific peptidase like 1 231915 Q3ULM6 ChIP (mouse brain)
Vernes SC 2011
V1RB1 vomeronasal 1 receptor 50 113852 Q9EP51 ChIP (mouse brain)
Vernes SC 2011
WASF1 WASP family 1 83767 Q8R5H6 ChIP (mouse brain)
Vernes SC 2011
WBP5 WW domain binding protein 5 22381 Q9DD24 ChIP (mouse brain)
Vernes SC 2011
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 22629 P68510 ChIP (mouse brain)
Vernes SC 2011
ZBTB5 zinc finger and BTB domain containing 5 230119 Q7TQG0 ChIP (mouse brain)
Vernes SC 2011
ZC3H11A zinc finger CCCH type containing 11A 70579 Q6NZF1 ChIP (mouse brain)
Vernes SC 2011
ZCCHC5 zinc finger, CCHC domain containing 5 213436 Q6P1Y1 ChIP (mouse brain)
Vernes SC 2011
ZFP248 zinc finger protein 248 72720 Q640N4 ChIP (mouse brain)
Vernes SC 2011
ZFP36 zinc finger protein 36 22695 P22893 ChIP (mouse brain)
Vernes SC 2011
ZFP521 zinc finger protein 521 225207 Q6KAS7 ChIP (mouse brain)
Vernes SC 2011
ZSWIM2 zinc finger, SWIM domain containing 2 71861 Q9D9X6 ChIP (mouse brain)
Vernes SC 2011

HELP