Genetic Mouse Models 252 Genetic mouse models

Database updated on March 28, 2024

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Status Gene Symbol Gene Name Number of Models Syntenic Human gene score Human Syndromic Rescue Model
ACTL6Bactin like 6B3YesSNo
ADNPActivity-dependent neuroprotector homeobox16No1SYes
ADORA2AAdenosine A2a receptor2Unknown2No
AHI1Abelson helper integration site 15UnknownSYes
ALDH5A1Aldehyde Dehydrogenase 5 family, member A14Unknown1SYes
ANK2ankyrin 2, neuronal15No1Yes
ANKRD11ankyrin repeat domain 113Unknown1SNo
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B8No2SYes
APBA2amyloid beta (A4) precursor protein-binding, family A, member 22Unknown2No
ARHGAP32Rho GTPase activating protein 323No2Yes
ARHGEF10Rho guanine nucleotide exchange factor 101No2No
ARID1BAT-rich interaction domain 1B18No1SYes
ARXaristaless related homeobox5Unknown1SNo
ASH1LASH1 like histone lysine methyltransferase13No1Yes
ASPMassembly factor for spindle microtubules1Yes2No
ATP1A3Sodium potassium ATPase alpha 3 subunit2Unknown2SYes
ATP2B2TPase, Ca++ transporting, plasma membrane 21No2No
ATRXATRX, chromatin remodeler1No1No
AUTS2AUTS2, activator of transcription and developmental regulator21No1Yes
ARNTLbasic helix-loop-helix ARNT like 14No3Yes
AVPR1AArginine vasopressin receptor 1A2Unknown2No
BCKDKbranched chain ketoacid dehydrogenase kinase3No1Yes
BCL11AB-cell CLL/lymphoma 11A4Yes1SNo
BRINP3BMP/retinoic acid inducible neural specific 31Yes3No
CACNA1Ccalcium voltage-gated channel subunit alpha1 C13Unknown1SNo
CACNA1Dcalcium voltage-gated channel subunit alpha1 D6No2Yes
CACNA1FCalcium channel, voltage-dependent, L type, alpha 1F subunit1No2No
CACNA1GCav3.1 T-type Ca2+ Channel7Unknown2No
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit1Unknown2No
CACNA2D3calcium voltage-gated channel auxiliary subunit alpha2delta 32Yes1No
CADM1cell adhesion molecule 14Unknown2No
CADPS2Ca2+-dependent activator protein for secretion 25Yes2No
CAMK2Acalcium/calmodulin dependent protein kinase II alpha2No2SNo
CAPRIN1RNA granule protein 105 (Caprin 1)2Unknown1No
CASKIN1CASK interacting protein 11No2No
CC2D1ACoiled-coil and C2 domain containing 1A10No2No
CD38CD38 molecule2Unknown2No
CDKL5cyclin-dependent kinase-like 510No1SYes
CELF4CUGBP, Elav-like family member 47No1No
CELF6CUGBP, Elav-like family member 61No2No
CHD2chromodomain helicase DNA binding protein 25No1SYes
CHD7Chromodomain Helicase DNA Binding Protein 75No1SYes
CHD8chromodomain helicase DNA binding protein 838No1SYes
CICcapicua transcriptional repressor8Yes1Yes
CNTN4contactin 43Unknown2No
CNTNAP2contactin associated protein-like 253Unknown2SYes
CNTNAP4contactin associated protein-like 47No2Yes
CSNK1Ecasein kinase 1, epsilon1No2No
CTNNB1catenin (cadherin associated protein), beta 11Yes1No
CTNND2Catenin(cadherin associated protein), delta 25No2Yes
CTTNBP2cortactin binding protein 2 19No2Yes
CUL3cullin 317No1Yes
CYFIP1Cytoplasmic FMR1 interacting protein 13No2Yes
DAGLAdiacylglycerol lipasealpha4No2No
DDX3XDEAD-box helicase 3 X-linked1Yes1SNo
DEAF1DEAF1, transcription factor9Yes1SNo
DHCR77-dehydrocholesterol reductase5No1SNo
DHX9DExH-box helicase 91No3SNo
DIP2Adisco interacting protein 2 homolog A2No1Yes
DISC1Disrupted in schizophrenia 113Unknown2Yes
DLG4discs, large homolog 4 (Drosophila)4Unknown1No
DLGAP1DLG associated protein 14No2No
DLGAP2DLG associated protein 22Yes2No
DMPKdystrophia myotonica-protein kinase2Unknown1SNo
DNMT3ADNA methyltransferase 3 alpha4Yes1SNo
DOCK4dedicator of cytokinesis 41No2No
DPP6dipeptidyl- petidase 61No2No
DPYSL3dihydropyrimidinase like 31Yes2No
DRD1Dopamine receptor D12No2No
DRD3Dopamine receptor D33Unknown2No
DSCAMDS cell adhesion molecule13No1No
DVL3Dishevelled segment polarity protein 35No2Yes
DYRK1Adual specificity tyrosine-Y- phosphorylation regulated kinase 1A10No1SYes
EEF1A2eukaryotic translation elongation factor 1 alpha 27NoSNo
EIF4EEukaryotic translation initiation factor 4E5Yes2Yes
EIF4G1eukaryotic translation initiation factor 4 gamma 12No3No
EN2Engrailed homeobox 25Unknown2No
EPHB2EPH receptor B25No2Yes
ERBINerbb2 interacting protein2No2No
ESRRBEstrogen-related receptor beta2Unknown2No
EXT1exostosin 11No2No
FEZF2FEZ family zinc finger 21Unknown2No
FMR1fragile X mental retardation 164Unknown1SYes
FOXG1Forkhead Box G18Unknown1SYes
FOXP1Forkhead box P19Unknown1SNo
FOXP2forkhead box P28Unknown1No
FRMD5FERM domain containing 52No3SNo
GABRB2gamma-aminobutyric acid type A receptor subunit beta28No1Yes
GABRB3gamma-aminobutyric acid type A receptor beta3 subunit23Unknown1Yes
GIGYF1GRB10 interacting GYF protein 16No1No
GLRA2glycine receptor, alpha 21Unknown2No
GRIA2Glutamate receptor, ionotropic, AMPA 21Unknown1No
GRID2glutamate receptor, ionotropic, delta 22No2No
GRIK2glutamate receptor, ionotropic, kainate 24No2Yes
GRID1glutamate receptor, ionotropic, delta 11No2No
GRIK4Glutamate receptor, ionotropic, kainate 412No2Yes
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 17No1Yes
GRIN2BGlutamate receptor, ionotropic, N-methyl D-aspartate 2B11No1No
GRIP1Glutamate receptor interacting protein 13Unknown2No
GRM5glutamate receptor, metabotropic 512No2No
GSTM1Glutathione S-transferase mu 11Unknown2No
GTF2Igeneral transcription factor Iii5Unknown2Yes
HDAC4Histone deacetylase 42Unknown2SNo
HMGN1High mobility group nucleosome binding domain 12Unknown2No
HNRNPUheterogeneous nuclear ribonucleoprotein U7No1SYes
HOMER1homer scaffolding protein 14No2No
HOXA1Homeobox A13UnknownSNo
HTR1B5-hydroxytryptamine (serotonin) receptor 1B2Unknown2No
HTR3A5-hydroxytryptamine (serotonin) receptor 3A3Unknown2No
IL1RAPL1interleukin 1 receptor accessory protein-like 12Unknown2No
IMMP2LIMP2 inner mitochondrial membrane peptidase-like2Unknown2No
IQSEC2IQ motif and Sec7 domain 21Yes1SNo
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)2Unknown2No
KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 13Yes2No
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 21Unknown2No
KCTD13potassium channel tetramerization domain containing 136Yes2No
KDM2Blysine demethylase 2B2No1No
KDM5Alysine demethylase 5A1Yes2No
KDM5Blysine demethylase 5B2No1No
KDM5Clysine demethylase 5C3Yes1No
KDM6Blysine demethylase 6B3No1Yes
KIRREL3Kin of Irregular Chiasm-like 31No2No
KLF7KLF transcription factor 77No3Yes
KMT2ALysine methyltransferase 2A4No1SNo
KMT2Clysine methyltransferase 2C1No1SNo
KMT2ELysine (K)-specific methyltransferase 2E1No1SNo
KMT5Blysine methyltransferase 5B2Yes1No
LRFN2leucine rich repeat and fibronectin type III domain containing 22No2No
LRRC4leucine rich repeat containing 44No2Yes
MAGEL2MAGE like 21No1SNo
MAOAMonoamine Oxidase A3Unknown2No
MAP1Bmicrotubule associated protein 1B1No2No
MBD3methyl-CpG binding domain protein 31Unknown2No
MBOAT7membrane bound O-acyltransferase domain containing 7 1Yes1SNo
MCPH1microcephalin 12Unknown2No
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 22No2No
MECP2methyl-CpG binding protein 295Yes1SYes
MEF2CMyocyte Enhancer Factor 2C15Unknown1SYes
METMET proto-oncogene, receptor tyrosine kinase10Unknown2No
MIR137microRNA 1376No2Yes
MTHFRmethylenetetrahydrofolate reductase (NAD(P)H)4No2Yes
MTORmechanistic target of rapamycin kinase3Yes1SYes
MYO5Amyosin VA4No2Yes
MYT1LMyelin transcription factor 1-like protein5Yes1Yes
NEGR1neuronal growth regulator 19No2Yes
NEXMIFneurite extension and migration factor1No1No
NF1neurofibromin 110Unknown1SYes
NLGN1neuroligin 110Unknown2No
NLGN2neuroligin 29No1No
NLGN3neuroligin 350Yes1Yes
NLGN4Xneuroligin 4, X-linked3Unknown1No
NPAS2neuronal PAS domain protein 22Unknown2No
NR2F1nuclear receptor subfamily 2 group F member 12Yes2SYes
NR3C2nuclear receptor subfamily 3, group C, member 22Unknown1SNo
NRCAMNeural cell adhesion molecule1Unknown2No
NRP2neuropilin 24Unknown2No
NRXN1neurexin 17Unknown1No
NTNG1Netrin G11Unknown2SNo
NTNG2Netrin G21UnknownSNo
NUAK1NUAK family, SNF1-like kinase, 16Unknown2No
OPHN1Oligophrenin 11Unknown2No
OTUD7AOTU deubiquitinase 7A2Yes2No
OXToxytocin/neurophysin I prepropeptide [Homo sapiens (human)7Yes2Yes
OXTROxytocin receptor17Unknown2Yes
PAK2p21 (RAC1) activated kinase 23No2Yes
PAX5Paired box 54No1No
PCDH10protocadherin 103Unknown2Yes
PCDH19protocadherin 194No1SNo
PCLOpiccolo presynaptic cytomatrix protein2No2Yes
PER1Period homolog 11Unknown2No
PITX1paired-like homeodomain 11Unknown2No
PLAURplasminogen activator, urokinase receptor1Unknown2No
PLPPR4phospholipid phosphatase related 48No3Yes
POGZpogo transposable element derived with ZNF domain8No1SYes
PRICKLE1prickle homolog 1 (Drosophila)7No2No
PRICKLE2prickle homolog 2 (Drosophila)2No2No
PRKCBProtein Kinase C, beta1Unknown2No
PRKDCProtein kinase, DNA activated, catalytic peptide2No2Yes
PRKNparkin RBR E3 ubiquitin protein ligase2Unknown2No
PTCHD1Patched domain containing 19No1Yes
PTENphosphatase and tensin homolog34Unknown1SYes
PTGS2prostaglandin-endoperoxide synthase 21No2No
RAB39BRAB39B, member RAS oncogene family2Yes2No
RAI1retinoic acid induced 112Unknown1SYes
RAPGEF4Rap guanine nucleotide exchange factor (GEF) 42Unknown2No
RBFOX1RNA binding protein, fox-1 homolog4Unknown2No
RHEBRas homolog, mTORC1 binding3NoSNo
RIMS1regulating synaptic membrane exocytosis 110Yes1No
RORBRAR related orphan receptor B2No1SNo
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 31No2SNo
SCGNsecretagogin, EF-hand calcium binding protein3No3Yes
SCN1Asodium channel, voltage-gated, type I, alpha subunit19Unknown1SYes
SCN2Asodium voltage-gated channel alpha subunit 29Unknown1Yes
SCN8Asodium channel, voltage gated, type VIII, alpha subunit1Unknown1No
SEMA5ASema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A1Unknown2No
SENP1SUMO1/sentrin specific peptidase 14No3Yes
SETD5SET domain containing 54No1SNo
SGSHN-sulfoglucosamine sulfohydrolase5YesSYes
SHANK1SH3 and multiple ankyrin repeat domains 14Unknown2No
SHANK2SH3 and multiple ankyrin repeat domains 224No1Yes
SHANK3SH3 and multiple ankyrin repeat domains 3107Unknown1SYes
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 28No3Yes
SLC25A12solute carrier family 25 (Mitochondrial carrier, Aralar), member 124Unknown2No
SLC35G1Solute carrier family 35 member G12No2No
SLC4A10Solute carrier 4, sodium bicarbonate transporter, member 101Unknown2No
SLC6A1Solute carrier family 6 member 11No1SNo
SLC6A3solute carrier family 6 member 315No2Yes
SLC6A4solute carrier family 6 member 414Unknown2Yes
SLC6A8Solute carrier family 6 member 82Yes2No
SLC7A5solute carrier family 7 member 53No2Yes
SLC9A6solute carrier family 9, subfamily A3No1SNo
SLC9A9solute carrier family 9 member A93Yes2No
SLITRK2SLIT and NTRK like family member 27NoSYes
SLITRK5SLIT and NTRK-like family, member 52No2No
SPTBN1Spectrin beta, non-erythrocytic 14Yes2SNo
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 25Unknown2Yes
STK39Serine threonine Kinase 39 (STE20/SPS1 homolog, yeast)1Unknown2No
STXBP1syntaxin binding protein 16Yes1SYes
SYN2Synapsin II3No2Yes
SYNGAP1synaptic Ras GTPase activating protein 1a16Unknown1SNo
TAOK2TAO kinase 212No2Yes
SYN1Synapsin I1No1No
TBR1T-box, brain 131No1Yes
TCF20transcription factor 205Yes1SYes
TCF4transcription factor 47No1SYes
TET2Tet methylcytosine dioxygenase 26No2Yes
THRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)1Unknown2No
TOP3BTopoisomerase (DNA) 3 Beta3No2No
TRIM32Tripartite motif containing 324No3Yes
TRIOTrio Rho guanine nucleotide exchange factor2No1No
TRPC6Transient receptor potential cation channel, subfamily C, member 64No2Yes
TSC1tuberous sclerosis 140Unknown1SYes
TCF7L2transcription factor 7 like 216No1Yes
TSC2tuberous sclerosis 225Unknown1SYes
TSHZ1teashirt zinc finger homeobox 13No1No
UBAP2Lubiquitin associated protein 2 like2No1No
UBE3Aubiquitin protein ligase E3A34Unknown1SYes
TSHZ3Teashirt zinc finger homeobox 34No1No
UPF2UPF2regulator of nonsense mediated mRNA decay3No2Yes
UPF3BUPF3B, regulator of nonsense mediated mRNA decay3No1SYes
USP7Ubiquitin specific peptidase 73No2SNo
VCPvalosin containing protein4No3Yes
WDFY3WD repeat and FYVE domain containing 34Unknown1No
ZBTB18Zinc finger and BTB domain containing 181NoSNo
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