Genetic Animal Models 262 Genetic animal models

Database updated on October 12, 2017

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Status Gene Symbol Gene Name Model Species Number of Models Syntenic Human gene score Human Syndromic Rescue Model
SLC6A3solute carrier family 6 member 3Mus musculus14No3Yes
SLC6A3solute carrier family 6 member 3Rattus norvegicus4No3Yes
UBA6ubiquitin-like modifier activating enzyme 6Mus musculus1No5No
SHANK2SH3 and multiple ankyrin repeat domains 2Mus musculus14No2Yes
DISC1Disrupted in schizophrenia 1Mus musculus11Unknown3No
DISC1Disrupted in schizophrenia 1Rattus norvegicus2Unknown3No
SLC6A4solute carrier family 6 member 4Mus musculus8Unknown4Yes
SLC6A4solute carrier family 6 member 4Rattus norvegicus3No4No
ATRNL1Attractin-like 1Mus musculus3Unknown5No
DMPKdystrophia myotonica-protein kinaseMus musculus2UnknownSNo
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1Mus musculus7No3Yes
IFNGInterferon gammaMus musculus3No5Yes
CAMK2Acalcium/calmodulin dependent protein kinase II alphaMus musculus2No4No
RAPGEF4Rap guanine nucleotide exchange factor (GEF) 4Mus musculus1Unknown4No
HCN1hyperpolarization activated cyclic nucleotide gated potassium channel 1Rattus norvegicus4NoSYes
PTENPhospatase and Tensin homologMus musculus21Unknown1SYes
GAP43growth associated protein 43Mus musculus1Unknown5No
KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 1Mus musculus3Yes4No
GRM8glutamate receptor, metabotropic 8Mus musculus1Unknown6No
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 2Mus musculus1Unknown3No
NTNG1Netrin G1Mus musculus1Unknown4SNo
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 3Mus musculus1No4SNo
WDFY3WD repeat and FYVE domain containing 3Mus musculus4Unknown2No
GADD45Bgrowth arrest and DNA-damage-inducible, betaMus musculus1No5No
GADD45Bgrowth arrest and DNA-damage-inducible, betaRattus norvegicus1No5No
SYN3Syanpsin IIIMus musculus1No5No
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunitMus musculus6UnknownSNo
DEAF1DEAF1, transcription factorMus musculus9Yes2SNo
IL1RAPL1interleukin 1 receptor accessory protein-like 1Mus musculus2Unknown4No
PARK2Parkinson disease (autosomal recessive, juvenile) 2, parkinMus musculus1Unknown3No
TSC2tuberous sclerosis 2Mus musculus15UnknownSYes
TSC2tuberous sclerosis 2Rattus norvegicus3UnknownSYes
GRID2glutamate receptor, ionotropic, delta 2Mus musculus2No4No
MECP2methyl-CpG binding protein 2Mus musculus62Unknown2SYes
MECP2methyl-CpG binding protein 2Rattus norvegicus3Unknown2SNo
OPRM1opioid receptor, mu 1Mus musculus3Yes5Yes
APBA2amyloid beta (A4) precursor protein-binding, family A, member 2Mus musculus2Unknown4No
CADPS2Ca2+-dependent activator protein for secretion 2Mus musculus5Yes4No
ATP1A3Sodium potassium ATPase alpha 3 subunitMus musculus2UnknownSYes
HTR3A5-hydroxytryptamine (serotonin) receptor 3AMus musculus3Unknown4No
CUL3cullin 3Mus musculus4No1No
CTNNB1catenin (cadherin associated protein), beta 1Mus musculus1Yes3No
PGLYRP2peptidoglycan recognition protein 2Mus musculus1No5No
OPHN1Oligophrenin 1Mus musculus1Unknown3No
CXCR3chemokine (C-X-C motif) receptor 3Mus musculus1Unknown5No
RAI1retinoic acid induced 1Mus musculus2UnknownSNo
ANKRD11ankyrin repeat domain 11Mus musculus3Unknown2SNo
FOLH1folate hydrolase (prostate-specific membrane antigen) 1Mus musculus3Yes5Yes
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Mus musculus2Unknown3No
PRICKLE1prickle homolog 1 (Drosophila)Mus musculus5No3No
NLGN4Xneuroligin 4, X-linkedMus musculus3Unknown3No
PRICKLE2prickle homolog 2 (Drosophila)Mus musculus2No3No
TPH2Tryptophan hydroxylase 2Mus musculus3No6No
NRP2neuropilin 2Mus musculus4Unknown4No
PCDH19protocadherin 19Mus musculus4NoSNo
GLRA2glycine receptor, alpha 2Mus musculus1Unknown5No
ANK2ankyrin 2, neuronalMus musculus2No1No
MBD3methyl-CpG binding domain protein 3Mus musculus1Unknown4No
SCN1Asodium channel, voltage-gated, type I, alpha subunitMus musculus18Unknown3SYes
SCN1Asodium channel, voltage-gated, type I, alpha subunitRattus norvegicus2Unknown3SYes
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2Mus musculus8NoSYes
AVPR1AArginine vasopressin receptor 1AMus musculus2Unknown3No
IMMP2LIMP2 inner mitochondrial membrane peptidase-likeMus musculus2Unknown5No
DAB1Disabled homolog 1Mus musculus1Unknown5No
DAB1Disabled homolog 1Rattus norvegicus1Unknown5No
SLC25A12solute carrier family 25 (Mitochondrial carrier, Aralar), member 12Mus musculus4Unknown4No
CLSTN3calsyntenin 3Mus musculus1No5No
RELNReelinMus musculus9Unknown1Yes
DYRK1Adual specificity tyrosine-Y- phosphorylation regulated kinase 1AMus musculus3No1SNo
SCN2Asodium channel, voltage-gated, type II, alpha subunitMus musculus3Unknown1No
EXT1exostosin 1Mus musculus1No4No
HOMER1homer scaffolding protein 1Mus musculus4No4No
HOMER1homer scaffolding protein 1Rattus norvegicus2No4No
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1Mus musculus2No5No
TERTTelomerase reverse transcriptaseMus musculus2No5Yes
ARID1BAT-rich interaction domain 1BMus musculus7No1SYes
NRXN2Neurexin2Mus musculus3No4No
NRXN1Neurexin 1Mus musculus2Unknown2No
NRXN1Neurexin 1Rattus norvegicus2Unknown2Yes
ALDH5A1Aldehyde Dehydrogenase 5 family, member A1Mus musculus4UnknownSYes
FOXP2Forkhead box P2Mus musculus9Unknown3No
FOXP1Forkhead box P1Mus musculus6Unknown2SNo
ADNPActivity-dependent neuroprotector homeoboxMus musculus8No1SYes
BCKDKbranched chain ketoacid dehydrogenase kinaseMus musculus3No2Yes
BCKDKbranched chain ketoacid dehydrogenase kinaseRattus norvegicus1No2No
ADORA2AAdenosine A2a receptorMus musculus2Unknown4No
USP7Ubiquitin specific peptidase 7Mus musculus1No2No
EN2Engrailed homeobox 2Mus musculus5Unknown4No
PCDH10protocadherin 10Mus musculus3Unknown4Yes
OXToxytocin/neurophysin I prepropeptide [Homo sapiens (human)Mus musculus7Yes4Yes
EIF4EEukaryotic translation initiation factor 4EMus musculus2Yes4Yes
TCF4transcription factor 4Mus musculus3NoSYes
TCF4transcription factor 4Rattus norvegicus4NoSYes
SEMA5ASema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5AMus musculus1Unknown3No
MEF2CMyocyte Enhancer Factor 2CMus musculus6Unknown4SNo
MAOAMonoamine Oxidase AMus musculus3Unknown4No
HDAC3Histone deacetylase 3Mus musculus1Yes5No
HDAC4Histone deacetylase 4Mus musculus2UnknownSNo
AHI1Abelson helper integration site 1Mus musculus3UnknownSNo
PRKDCProtein kinase, DNA activated, catalytic peptideMus musculus2No4Yes
GABRA5Gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5Mus musculus1Yes5No
HMGN1High mobility group nucleosome binding domain 1Mus musculus2Unknown3No
CDKL5cyclin-dependent kinase-like 5Mus musculus2NoSNo
CADM1cell adhesion molecule 1Mus musculus4Unknown4No
NLGN3neuroligin 3Mus musculus28Yes2Yes
NLGN3neuroligin 3Rattus norvegicus1Yes2No
NLGN1neuroligin 1Mus musculus10Unknown3No
PTCHD1Patched domain containing 1Mus musculus7No2Yes
GRIK2glutamate receptor, ionotropic, kainate 2Mus musculus4No3Yes
GRIK4Glutamate receptor, ionotropic, kainate 4Mus musculus8No5Yes
VLDLRvery low density lipoprotein receptorRattus norvegicus1Unknown5No
HOXA1Homeobox A1Mus musculus3UnknownSNo
CRHR2Corticotropin releasing hormone receptor2Mus musculus2No5No
PITX1paired-like homeodomain 1Mus musculus1Unknown4No
DVL3Dishevelled segment polarity protein 3Mus musculus5No4Yes
DVL1Dishevelled segment polarity protein 1Mus musculus8No5Yes
PRKCBProtein Kinase C, betaMus musculus1Unknown3No
SPASTSpastinMus musculus1No2No
ARHGAP32Rho GTPase activating protein 32Mus musculus3No4Yes
ARHGAP33Rho GTPase activating protein 33Mus musculus6No5Yes
HTR1B5-hydroxytryptamine (serotonin) receptor 1BMus musculus2Unknown4No
SLC6A1Solute carrier family 6 member 1Mus musculus1No2No
CAPRIN1RNA granule protein 105 (Caprin 1)Mus musculus2Unknown3No
PLNPhospholambanMus musculus1Unknown4No
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunitMus musculus1Unknown2No
TSC1Tuberous sclerosis 1Mus musculus17UnknownSYes
CACNA1FCalcium channel, voltage-dependent, L type, alpha 1F subunitMus musculus1No4No
CACNA1GCav3.1 T-type Ca2+ ChannelMus musculus6Unknown4No
NF1neurofibromin 1Mus musculus9UnknownSYes
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Mus musculus2Unknown5No
PER1Period homolog 1Mus musculus1Unknown4No
GTF2Igeneral transcription factor IiiMus musculus2Unknown4No
MAGEL2MAGE like 2Mus musculus1No2SNo
TOP3BTopoisomerase (DNA) 3 BetaMus musculus2No4No
DMDDystrophinMus musculus6UnknownSNo
CC2D1ACoiled-coil and C2 domain containing 1AMus musculus5No3No
IFNGR1Interferon gamma receptor 1Mus musculus1No5No
SLC9A6solute carrier family 9, subfamily AMus musculus3NoSNo
METmet Proto-oncogeneMus musculus8Unknown2No
RBFOX1RNA binding protein, fox-1 homologMus musculus2Unknown3No
ERBINerbb2 interacting proteinMus musculus2No2No
SLC6A8Solute carrier family 6 member 8Mus musculus2Yes4No
PAX6paired box 6Rattus norvegicus2NoSYes
EIF4EBP2eukaryotic translation initiation factor 4E binding protein 2Mus musculus5No5Yes
SYN1Synapsin IMus musculus1No4No
SLC4A10Solute carrier 4, sodium bicarbonate transporter, member 10Mus musculus1Unknown4No
TBX1T-box1Mus musculus1Unknown4No
CTNND2Catenin(cadherin associated protein), delta 2Mus musculus1Yes2No
STAT1Signal transducer and activator of transcription 1Mus musculus2No5No
CBLN1Cerebellin 1 precursorMus musculus7No5No
GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3Mus musculus17Unknown2Yes
GSTM1Glutathione S-transferase mu 1Mus musculus1Unknown4No
Slc30a3Solute carrier family 30 (zinc transporter), member 3Mus musculus2Yes5Yes
JAKMIP1janus kinase and microtubule interacting protein 1Mus musculus1Yes5No
FMR1Fragile X Mental Retardation 1Mus musculus41UnknownSYes
FMR1Fragile X Mental Retardation 1Rattus norvegicus1UnknownSNo
UCN3Urocortin 3Mus musculus2No5No
NPAS2neuronal PAS domain protein 2Mus musculus1Unknown4No
ATG7Autophagy related 7Mus musculus2No5Yes
NRG1neuregulin 1Mus musculus1No5No
DPP6dipeptidyl- petidase 6Mus musculus1No4No
POU3F2POU class 3 homeobox 2Mus musculus2No5No
KMT2ALysine methyltransferase 2AMus musculus3No1SNo
ESRRBEstrogen-related receptor betaMus musculus2Unknown4No
STK39Serine threonine Kinase 39 (STE20/SPS1 homolog, yeast)Mus musculus1Unknown4No
GRPRgastrin-releasing peptide receptorMus musculus5Unknown5No
FEZF2FEZ family zinc finger 2Mus musculus1Unknown4No
ARXaristaless related homeoboxMus musculus4UnknownSNo
DRD3Dopamine receptor D3Mus musculus3Unknown4No
SRRM4Serine/arginine repetitive matrix 4Mus musculus2Yes5No
NRCAMNeural cell adhesion moleculeMus musculus1Unknown4No
DHCR77-dehydrocholesterol reductaseMus musculus5NoSNo
LRFN2leucine rich repeat and fibronectin type III domain containing 2Mus musculus2No4No
CSNK1Dcasein kinase 1, deltaMus musculus3No6No
CACNA2D3calcium voltage-gated channel auxiliary subunit alpha2delta 3Mus musculus2Yes2No
ATP2B2TPase, Ca++ transporting, plasma membrane 2Mus musculus1No3No
BRINP1BMP/RA-inducible neural-specific protein 1Mus musculus3Unknown5Yes
GSK3Bglycogen synthase kinase 3 betaMus musculus1Unknown5No
GRIP1Glutamate receptor interacting protein 1Mus musculus3Unknown2No
NR3C2nuclear receptor subfamily 3, group C, member 2Mus musculus2Unknown3No
TBR1T-box, brain 1Mus musculus9No1Yes
TRPC6Transient receptor potential cation channel, subfamily C, member 6Mus musculus4No3Yes
CHD2chromodomain helicase DNA binding protein 2Mus musculus2No2SNo
CHD5chromodomain helicase DNA binding protein 5Mus musculus2No5No
CHD7chromodomain helicase DNA binding protein 7Mus musculus4NoSYes
UBE3Bubiquitin protein ligase E3BMus musculus1No5No
CHD8chromodomain helicase DNA binding protein 8Mus musculus15No1SYes
UBE3Aubiquitin protein ligase E3AMus musculus30Unknown3SYes
NBEAneurobeachinMus musculus2Unknown4No
HTR2A5-hydroxytryptamine (serotonin) receptor 2AMus musculus4Unknown5No
APCadenomatous polyposis coliMus musculus2No5No
SYNGAP1synaptic Ras GTPase activating protein 1Mus musculus9Unknown1SNo
AVParginine vasopressinRattus norvegicus6No5Yes
BAIAP2BAI1-associated protein 2Mus musculus4Unknown5Yes
MCPH1microcephalin 1Mus musculus2Unknown4No
EPHA6EPH Receptor A6Mus musculus1Unknown5No
GAD1glutamate decarboxylase 1 (brain, 67kDa)Mus musculus1No5No
MAPK1mitogen-activated protein kinase 1Mus musculus1Unknown5No
ASH1LASH1 like histone lysine methyltransferaseMus musculus6No1Yes
SLC7A5solute carrier family 7 member 5Mus musculus2No3Yes
ATP8A1Aminophospholipid translocase, filppase, 8a1Mus musculus2Yes5No
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2Mus musculus1Yes5No
WWOXWW domain containing oxidoreductaseRattus norvegicus1No3No
HDChistidine decarboxylaseMus musculus20No5Yes
CICcapicua transcriptional repressorMus musculus8Yes2SYes
AUTS2Autism susceptibility candidate 2Mus musculus2No3No
CNTN4contactin 4Mus musculus1Unknown2No
FOXG1Forkhead Box G1Mus musculus1UnknownSNo
BCL11AB-cell CLL/lymphoma 11AMus musculus2Yes2SNo
SLC33A1Solute carrier family 33 member 1Mus musculus2Unknown5Yes
CNTNAP2contactin associated protein-like 2Mus musculus26Unknown2SYes
CNTNAP2contactin associated protein-like 2Rattus norvegicus1Unknown2SNo
CNTNAP4contactin associated protein-like 4Mus musculus7No3Yes
DSCAMDown syndrome cell adhesion moleculeMus musculus11No1No
OXTROxytocin receptorMus musculus13Unknown3Yes
P2RX4purinergic receptor P2X, ligand-gated ion channel, 4Mus musculus2No5No
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2Mus musculus2No4No
TSHZ3Teashirt zinc finger homeobox 3Mus musculus2No4No
SHANK3SH3 and multiple ankyrin repeat domains 3Mus musculus38Unknown1SYes
SHANK3SH3 and multiple ankyrin repeat domains 3Rattus norvegicus4Unknown1SYes
SHANK1SH3 and multiple ankyrin repeat domains 1Mus musculus2Unknown3No
PVALBParvalbuminMus musculus3No5No
GRIN2BGlutamate receptor, ionotropic, N-methyl D-aspartate 2BMus musculus10No1No
DLG4discs, large homolog 4 (Drosophila)Mus musculus1UnknownNo
CELF4CUGBP, Elav-like family member 4Mus musculus7NoNo
GRM5glutamate receptor, metabotropic 5Mus musculus12NoNo
GRID1glutamate receptor, ionotropic, delta 1Mus musculus1NoNo
EEF1A2eukaryotic translation elongation factor 1 alpha 2Mus musculus7NoNo
EPS8epidermal growth factor receptor pathway substrate 8Mus musculus1NoNo
SLITRK5SLIT and NTRK-like family, member 5Mus musculus2NoNo
SCN8Asodium channel, voltage gated, type VIII, alpha subunitMus musculus1UnknownNo
NLGN2neuroligin 2Mus musculus4NoNo
NLGN2neuroligin 2Rattus norvegicus1NoNo
PLAURplasminogen activator, urokinase receptorMus musculus1UnknownNo
APPamyloid beta (A4) precursor proteinMus musculus1NoNo
TYRtyrosinase (oculocutaneous albinism IA)Mus musculus1UnknownNo
CELF6CUGBP, Elav-like family member 6Mus musculus1NoNo
CD38CD38 moleculeMus musculus1UnknownNo
LRRC7Leucine rich repeat containing 7Mus musculus1UnknownNo
THRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Mus musculus1UnknownNo
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2Mus musculus1UnknownNo
CYFIP1Cytoplasmic FMR1 interacting protein 1Mus musculus1NoNo
SYN2Synapsin IIMus musculus1NoNo
DRD1Dopamine receptor D1Mus musculus2NoNo
DRD1Dopamine receptor D1Rattus norvegicus1NoNo
BDNFbrain-derived neurotrophic factorMus musculus1NoNo
RASD1RAS, dexamethasone induced 1Mus musculus2NoNo
CNTNAP1contactin associated protein 1Mus musculus3UnknownNo
CSNK1Ecasein kinase 1, epsilonMus musculus1NoNo
DRD4dopamine receptor D4Mus musculus1UnknownNo
GRIA2Glutamate receptor, ionotropic, AMPA 2Mus musculus1UnknownNo
GSC2goosecoid homeobox 2Mus musculus1UnknownNo
HOMER2homer homolog 2Mus musculus1NoNo
HOMER3homer homolog 3Mus musculus1NoNo
MBD2methyl-CpG binding domain protein 2Mus musculus2UnknownNo
NOS2Nitric Oxide Synthase 2, inducibleMus musculus1UnknownNo
NTNG2Netrin G2Mus musculus1UnknownNo
PIK3R6phosphoinositide-3-kinase, regulatory subunit 6Mus musculus2UnknownNo
RBFOX2RNA binding protein, fox-1 homologMus musculus1UnknownNo
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 1Mus musculus1NoNo
SLC16A8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)Mus musculus1NoNo
TRPV1transient receptor potential cation channel, subfamily V, member 1Mus musculus1NoNo
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