MIR137 microRNA 137
Model Species
Mus musculusGene Aliases
Mirn137, mir-137, mmu-mir-137Models / Rescue Models
6 / 2Rescue Model
-Model Summary
Mice with homozygous germline KO of miR-137 or neural selective CKO show postnatal lethality with decrease in body and brain size, while heterozygotes show deficits in synaptic plasticity and learning, repetitive behavior, impaired social interaction, and elevated PDE10a. Treatment with Pde10a or KD of Pde10a rescues deficits in mir137 HT mice.
External Links
Reports related to MIR137 (1 Reports)
| # | Type | Title | Author, Year |
|---|---|---|---|
| 1 | Primary | Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. | Cheng Y , et al. (2018) |
Show all Construct Details
Show all Phenotypic Profiles
M_MIR137_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mir137 gene was disrupted via homologous recombination in ES cells, where two loxP sites were inserted -2kb unstream and -0.6kb downstream of the Mir137 gene. Conditional ready mice were crossed with Zp3-Cre mic to delete Mir137 in the germline.
Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Motor phenotype | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Immunohistochemistry | P18, 8 weeks | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | Decreased | Measurement of tissue weight | P16 | Cheng Y , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Social behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Developmental profile | Size/growth | No change | Gross necroscopy | P0 | Cheng Y , et al. (2018) |
| Developmental profile | Size/growth | Decreased | Body weight measurement | P16 | Cheng Y , et al. (2018) |
| Developmental profile | Respiratory system development | Decreased | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Respiratory system development | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Renal morphology | Decreased | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Renal morphology | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Mortality/lethality | Decreased | Kaplan-meier survival curve | P0-3.4 months | Cheng Y , et al. (2018) |
| Developmental profile | Digestive system development | Decreased | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Digestive system development | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Cardiovascular development and function | Decreased | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Cardiovascular development and function | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Polymerase chain reaction (pcr) | E15.5, p0, p14 | Cheng Y , et al. (2018) |
| Molecular profile | Protein expression level evidence | No change | Western blot | P12 | Cheng Y , et al. (2018) |
| Molecular profile | Protein expression level evidence | Increased | Western blot | P12 | Cheng Y , et al. (2018) |
| Molecular profile | Gene expression | No change | Polymerase chain reaction (pcr) | E15.5, p0, p14 | Cheng Y , et al. (2018) |
| Molecular profile | Gene expression | Abnormal | Tandem mass tagging (tmt) | P12 | Cheng Y , et al. (2018) |
M_MIR137_2_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Mir137 gene was disrupted via homologous recombination in ES cells, where two loxP sites were inserted -2kb unstream and -0.6kb downstream of the Mir137 gene. Conditional ready mice were crossed with Zp3-Cre mic to delete Mir137 in the germline.
Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Motor phenotype | Swimming ability | No change | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Immunohistochemistry | P18, 8 weeks | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Brain size | No change | Measurement of tissue weight | P16 | Cheng Y , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social memory | Decreased | Social recognition test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Developmental profile | Size/growth | No change | Body weight measurement | P16 | Cheng Y , et al. (2018) |
| Developmental profile | Respiratory system development | No change | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Respiratory system development | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Renal morphology | No change | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Renal morphology | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Mortality/lethality | Increased | Kaplan-meier survival curve | P0-3.4 months | Cheng Y , et al. (2018) |
| Developmental profile | Digestive system development | No change | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Digestive system development | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Cardiovascular development and function | No change | Gross necroscopy | P14 | Cheng Y , et al. (2018) |
| Developmental profile | Cardiovascular development and function | No change | Histology | P14 | Cheng Y , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Decreased | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Decreased | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial reference memory | Decreased | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial reference memory | Decreased | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Polymerase chain reaction (pcr) | E15.5, p0, p14 | Cheng Y , et al. (2018) |
| Molecular profile | Protein phosphorylation | Decreased | Western blot | P12 | Cheng Y , et al. (2018) |
| Molecular profile | Protein expression level evidence | No change | Western blot | P12 | Cheng Y , et al. (2018) |
| Molecular profile | Protein expression level evidence | Increased | Western blot | P12 | Cheng Y , et al. (2018) |
M_MIR137_3_CKO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Conditional deletion of the microRNA Mir137 gene using Nestin-Cre, in neuronal, glial and other cell types in the central and peripheral nervous system
Allele Type: Conditional loss-of-function
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Motor phenotype | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Immunohistochemistry | P18 | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Western blot | P18 | Cheng Y , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Social behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Developmental profile | Mortality/lethality | Increased | Kaplan-meier survival curve | P0-3.4 months | Cheng Y , et al. (2018) |
| Developmental profile | General characteristics | No change | Gross necroscopy | E15.5 | Cheng Y , et al. (2018) |
| Emotion | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | E15.5, p0, p14 | Cheng Y , et al. (2018) |
M_MIR137_4_CKO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Conditional heterozygous deletion of the microRNA Mir137 gene using Nestin-Cre, in neuronal, glial and other cell types in the central and peripheral nervous system
Allele Type: Conditional loss-of-function
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Motor phenotype | Swimming ability | No change | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Motor phenotype | Self grooming: artificial stress evoked | Increased | Reciprocal social interaction test | 2-3 months | Cheng Y , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Immunohistochemistry | P18 | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Synapse density | Increased | Western blot | P18 | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: spine density | Increased | Golgi-cox staining | 2 weeks | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic tree complexity | Increased | Golgi-cox staining | 2 weeks | Cheng Y , et al. (2018) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Dendritic architecture: dendritic length | Increased | Golgi-cox staining | 2 weeks | Cheng Y , et al. (2018) |
| Neurophysiology | Synaptic transmission | Decreased | Whole-cell patch clamp | 2-3 months | Cheng Y , et al. (2018) |
| Neurophysiology | Synaptic plasticity: hippocampal ltp | Decreased | Field potential recordings | 2-3 months | Cheng Y , et al. (2018) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | Decreased | Paired-pulse ratio | 2-3 months | Cheng Y , et al. (2018) |
| Neurophysiology | Apoptosis: brain cells | No change | Immunohistochemistry | P0, p18, 2 months | Cheng Y , et al. (2018) |
| Repetitive behavior | Self grooming: perseveration | Increased | Grooming behavior assessments | 2-3 months | Cheng Y , et al. (2018) |
| Repetitive behavior | Repetitive digging | Increased | Marble-burying test | 2-3 months | Cheng Y , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Social behavior | Social memory | Decreased | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social memory | Decreased | Social recognition test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social interaction | Decreased | Reciprocal social interaction test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Developmental profile | Mortality/lethality | No change | Kaplan-meier survival curve | P0-3.4 months | Cheng Y , et al. (2018) |
| Developmental profile | General characteristics | No change | Gross necroscopy | E15.5 | Cheng Y , et al. (2018) |
| Emotion | Anxiety | Increased | Open field test | 2-3 months | Cheng Y , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Decreased | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Decreased | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial reference memory | Decreased | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial reference memory | Decreased | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Quantitative pcr (qrt-pcr) | E15.5, p0, p14 | Cheng Y , et al. (2018) |
| Molecular profile | Protein phosphorylation | Decreased | Western blot | P12 | Cheng Y , et al. (2018) |
| Molecular profile | Protein expression level evidence | Increased | Western blot | P12 | Cheng Y , et al. (2018) |
M_MIR137_4_CKO_HT_PAPAVERINE
Model Type: RESCUE-Pharmaceutical
Model Genotype: Heterozygous
Mutation:
Mir137 het CKOs, with partial loss of the microRNA from central and peripheral nervous system, were treated with a Pde10a-specific inhibitor, papaverine, 30 mg/kg (i.p.)
Allele Type: Conditional loss-of-function
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Motor phenotype | Swimming ability | No adverse effect | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No adverse effect | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No adverse effect | Open field test | 2-3 months | Cheng Y , et al. (2018) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Neurophysiology | Synaptic plasticity: hippocampal ltp | Ameliorated | Field potential recordings | 2-3 months | Cheng Y , et al. (2018) |
| Neurophysiology | Presynaptic function: paired-pulse facilitation | Ameliorated | Paired-pulse ratio | 2-3 months | Cheng Y , et al. (2018) |
| Repetitive behavior | Self grooming: perseveration | Ameliorated | Grooming behavior assessments | 2-3 months | Cheng Y , et al. (2018) |
| Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 2-3 months | Cheng Y , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Social behavior | Social memory | Ameliorated | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Emotion | Anxiety | Refractory | Open field test | 2-3 months | Cheng Y , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Ameliorated | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Ameliorated | Barnes maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial reference memory | Ameliorated | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Molecular profile | Protein phosphorylation | Restored | Western blot | P12 | Cheng Y , et al. (2018) |
| Molecular profile | Protein expression level evidence | Restored | Western blot | P12 | Cheng Y , et al. (2018) |
M_MIR137_4_CKO_HT_PDE10A-KNOCKDOWN
Model Type: RESCUE-Genetic
Model Genotype: Heterozygous
Mutation:
Genetic rescue for heterozygous, conditional loss of Mir137 from the central and peripheral nervous system via knockdown of Pde10a using lentiviruses encoding shRNAs
Allele Type: Conditional loss-of-function
Strain of Origin: Not reported
Genetic Background: 129S6/SvEvTac
Es cell line: -
Model Source: -
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Motor phenotype | Swimming ability | No adverse effect | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No adverse effect | Open field test | 2-3 months | Cheng Y , et al. (2018) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Repetitive behavior | Self grooming: perseveration | Refractory | Grooming behavior assessments | 2-3 months | Cheng Y , et al. (2018) |
| Repetitive behavior | Repetitive digging | Restored | Marble-burying test | 2-3 months | Cheng Y , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Social behavior | Social memory | Ameliorated | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Social behavior | Social approach | Ameliorated | Three-chamber social approach test | 2-3 months | Cheng Y , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Emotion | Anxiety | Restored | Open field test | 2-3 months | Cheng Y , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Learning & memory | Spatial working memory | Ameliorated | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Learning & memory | Spatial reference memory | Ameliorated | Morris water maze test | 2-3 months | Cheng Y , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
| Molecular profile | NA | Not reported | NA | NA | Cheng Y , et al. (2018) |
Other MIR137 Rescue Models(2 Models)
| M_MIR137_4_CKO_HT | 1 | Genetic | Pharmaceutical | Papaverine |
| M_MIR137_4_CKO_HT | 1 | Genetic | Genetic | Ablation of Pde10a |
CNVs associated with MIR137(1 Models)
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| 1p21.3 | 16 | Deletion-Duplication | 28 / 58 |