Induced Mouse Models / Polyinosinic:polycytidylic acid

Polyinosinic:polycytidylic acid

Model Species
Mus musculus
Model Subtype
Biological
Reports
24
Inducer Symbol
PolyI:C
Induced Models / Rescue Models
71 / 22
Rescue Model
Yes
Model Summary

A model to experimentally show that prenatal immune activation is an environmental risk factor for adult ventricular enlargement.

Human Clinical Evidence

Strong epidemiological evidence suggests that maternal infection during prenatal life may contribute to an increased risk of schizophrenia or autism in offspring

External Links
PubChemWikipedia
Reports related to Polyinosinic:polycytidylic acid (24 Reports)
# Type Title Author, Year
1 Primary Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. Shi L , et al. (2003)
2 Additional Maternal immune activation alters fetal brain development through interleukin-6. Smith SE , et al. (2007)
3 Additional Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. Li Q , et al. (2009)
4 Additional Voxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy. Li Q , et al. (2010)
5 Additional Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Malkova NV , et al. (2012)
6 Additional Modeling an autism risk factor in mice leads to permanent immune dysregulation. Hsiao EY , et al. (2012)
7 Additional Effects of maternal immune activation on gene expression patterns in the fetal brain. Garbett KA , et al. (2012)
8 Additional Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. Schwartzer JJ , et al. (2013)
9 Additional Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. Naviaux RK , et al. (2013)
10 Additional Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring. Giulivi C , et al. (2013)
11 Additional Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Hsiao EY , et al. (2013)
12 Additional The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Choi GB , et al. (2016)
13 Additional Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons. Canetta S , et al. (2016)
14 Additional Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia. Lim JS , et al. (2017)
15 Additional Reversing behavioural abnormalities in mice exposed to maternal inflammation. Shin Yim Y , et al. (2017)
16 Additional Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Kim S , et al. (2017)
17 Additional Maternal Immune Activation Delays Excitatory-to-Inhibitory Gamma-Aminobutyric Acid Switch in Offspring. Corradini I , et al. (2017)
18 Additional Strain differences in the susceptibility to the gut-brain axis and neurobehavioural alterations induced by maternal immune activation in mice. Morais LH , et al. (2018)
19 Additional GABAergic malfunction in the anterior cingulate cortex underlying maternal immune activation-induced social deficits. Okamoto K , et al. (2018)
20 Additional P2X7 receptors drive poly(I:C) induced autism-like behavior in mice. Horvth G , et al. (2019)
21 Additional Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism. Haida O , et al. (2019)
22 Additional Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Orefice LL , et al. (2019)
23 Additional IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders </title> ()
24 Additional Inhibition of Colony Stimulating Factor 1 Receptor Corrects Maternal Inflammation-Induced Microglial and Synaptic Dysfunction and Behavioral Abnormalities </title> ()
Exposure

Prenatal exposure from mother

Mode of Action

Maternal immune activation

Usage

Immunostimulant

Show all Rescue Paradigms Show all Phenotypic Profiles

M_POLYIC_10_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant dams recived a dual administration of PolyI:C on E12.5 (3 mg/kg or 0.25U/g) and E17.5 (1.5 mg/kg or 0.125U/g) (cohort 2 as in PMID 23516405 wherein nulliparous dams were mated at 9-10 weeks with sires of the same age).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: dark phase No change Open field test 8 weeks Naviaux RK , et al. (2013)
Communications - Not reported - - Naviaux RK , et al. (2013)
Developmental profile Mortality/lethality Decreased General observations P0 Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body length measurement 14 weeks Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body weight measurement 14 weeks Naviaux RK , et al. (2013)
Emotion - Not reported - - Naviaux RK , et al. (2013)
Immune response Adaptive immune response: b cells antibody production No change Antibody levels 15 weeks Naviaux RK , et al. (2013)
Learning & memory - Not reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not reported - - Naviaux RK , et al. (2013)
Molecular profile - Not reported - - Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 16 weeks Naviaux RK , et al. (2013)
Neurophysiology - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Decreased Body temperature measurement 8-16 weeks, 8 months Naviaux RK , et al. (2013)
Physiological parameters Hormone levels No change Corticosterone measurements 12 weeks Naviaux RK , et al. (2013)
Physiological parameters Respiratory function No change Respiration rate and pattern analysis 4 months Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Water intake measurements Unreported Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Food intake measurements Unreported Naviaux RK , et al. (2013)
Repetitive behavior - Not reported - - Naviaux RK , et al. (2013)
Seizure - Not reported - - Naviaux RK , et al. (2013)
Sensory - Not reported - - Naviaux RK , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Naviaux RK , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Okamoto K , et al. (2018)
Communications - Not reported - - Okamoto K , et al. (2018)
Developmental profile Size/growth No change Body weight measurement 4-6 weeks Okamoto K , et al. (2018)
Emotion Exploratory activity No change Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Immune response - Not reported - - Okamoto K , et al. (2018)
Learning & memory - Not reported - - Okamoto K , et al. (2018)
Maternal behavior - Not reported - - Okamoto K , et al. (2018)
Molecular profile Protein localization: synapse Decreased Immunohistochemistry 4-6 weeks Okamoto K , et al. (2018)
Motor phenotype - Not reported - - Okamoto K , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Okamoto K , et al. (2018)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents Increased Whole-cell patch clamp 4-6 weeks Okamoto K , et al. (2018)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Increased Whole-cell patch clamp 4-6 weeks Okamoto K , et al. (2018)
Physiological parameters - Not reported - - Okamoto K , et al. (2018)
Repetitive behavior - Not reported - - Okamoto K , et al. (2018)
Seizure - Not reported - - Okamoto K , et al. (2018)
Sensory - Not reported - - Okamoto K , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response - Not reported - - Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-3 months Horvth G , et al. (2019)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 2-3 months Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry Adult Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Abnormal Electron microscopy Adult Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior Repetitive digging Increased Marble-burying test 2-3 months Horvth G , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 2-3 months Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 2-3 months Horvth G , et al. (2019)
Neurophysiology Synaptic transmission: excitatory No change Whole-cell patch clamp - -
Neurophysiology Synaptic transmission: inhibitory Decreased Whole-cell patch clamp - -
Physiological parameters Respiratory function Decreased Respiration rate and pattern analysis - -

M_POLYIC_10_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant dams recived a dual administration of PolyI:C on E12.5 (3 mg/kg or 0.25U/g) and E17.5 (1.5 mg/kg or 0.125U/g) (cohort 2 as in PMID 23516405 wherein nulliparous dams were mated at 9-10 weeks with sires of the same age).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: dark phase No change Open field test 8 weeks Naviaux RK , et al. (2013)
Communications - Not reported - - Naviaux RK , et al. (2013)
Developmental profile Mortality/lethality Decreased General observations P0 Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body length measurement 14 weeks Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body weight measurement 14 weeks Naviaux RK , et al. (2013)
Emotion - Not reported - - Naviaux RK , et al. (2013)
Immune response Adaptive immune response: b cells antibody production No change Antibody levels 15 weeks Naviaux RK , et al. (2013)
Learning & memory - Not reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not reported - - Naviaux RK , et al. (2013)
Molecular profile - Not reported - - Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 16 weeks Naviaux RK , et al. (2013)
Neurophysiology - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Decreased Body temperature measurement 8-16 weeks, 8 months Naviaux RK , et al. (2013)
Physiological parameters Hormone levels No change Corticosterone measurements 12 weeks Naviaux RK , et al. (2013)
Physiological parameters Respiratory function No change Respiration rate and pattern analysis 4 months Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Water intake measurements Unreported Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Food intake measurements Unreported Naviaux RK , et al. (2013)
Repetitive behavior - Not reported - - Naviaux RK , et al. (2013)
Seizure - Not reported - - Naviaux RK , et al. (2013)
Sensory - Not reported - - Naviaux RK , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Naviaux RK , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Okamoto K , et al. (2018)
Communications - Not reported - - Okamoto K , et al. (2018)
Developmental profile Size/growth No change Body weight measurement 4-6 weeks Okamoto K , et al. (2018)
Emotion Exploratory activity No change Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Immune response - Not reported - - Okamoto K , et al. (2018)
Learning & memory - Not reported - - Okamoto K , et al. (2018)
Maternal behavior - Not reported - - Okamoto K , et al. (2018)
Molecular profile Protein localization: synapse Decreased Immunohistochemistry 4-6 weeks Okamoto K , et al. (2018)
Motor phenotype - Not reported - - Okamoto K , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Okamoto K , et al. (2018)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents Increased Whole-cell patch clamp 4-6 weeks Okamoto K , et al. (2018)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Increased Whole-cell patch clamp 4-6 weeks Okamoto K , et al. (2018)
Physiological parameters - Not reported - - Okamoto K , et al. (2018)
Repetitive behavior - Not reported - - Okamoto K , et al. (2018)
Seizure - Not reported - - Okamoto K , et al. (2018)
Sensory - Not reported - - Okamoto K , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response - Not reported - - Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-3 months Horvth G , et al. (2019)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 2-3 months Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry Adult Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Abnormal Electron microscopy Adult Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior Repetitive digging Increased Marble-burying test 2-3 months Horvth G , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 2-3 months Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 2-3 months Horvth G , et al. (2019)
Neurophysiology Synaptic transmission: excitatory No change Whole-cell patch clamp - -
Neurophysiology Synaptic transmission: inhibitory Decreased Whole-cell patch clamp - -
Physiological parameters Respiratory function Decreased Respiration rate and pattern analysis - -

M_POLYIC_10_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant dams recived a dual administration of PolyI:C on E12.5 (3 mg/kg or 0.25U/g) and E17.5 (1.5 mg/kg or 0.125U/g) (cohort 2 as in PMID 23516405 wherein nulliparous dams were mated at 9-10 weeks with sires of the same age).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: dark phase No change Open field test 8 weeks Naviaux RK , et al. (2013)
Communications - Not reported - - Naviaux RK , et al. (2013)
Developmental profile Mortality/lethality Decreased General observations P0 Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body length measurement 14 weeks Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body weight measurement 14 weeks Naviaux RK , et al. (2013)
Emotion - Not reported - - Naviaux RK , et al. (2013)
Immune response Adaptive immune response: b cells antibody production No change Antibody levels 15 weeks Naviaux RK , et al. (2013)
Learning & memory - Not reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not reported - - Naviaux RK , et al. (2013)
Molecular profile - Not reported - - Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 16 weeks Naviaux RK , et al. (2013)
Neurophysiology - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Decreased Body temperature measurement 8-16 weeks, 8 months Naviaux RK , et al. (2013)
Physiological parameters Hormone levels No change Corticosterone measurements 12 weeks Naviaux RK , et al. (2013)
Physiological parameters Respiratory function No change Respiration rate and pattern analysis 4 months Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Water intake measurements Unreported Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Food intake measurements Unreported Naviaux RK , et al. (2013)
Repetitive behavior - Not reported - - Naviaux RK , et al. (2013)
Seizure - Not reported - - Naviaux RK , et al. (2013)
Sensory - Not reported - - Naviaux RK , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Naviaux RK , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Okamoto K , et al. (2018)
Communications - Not reported - - Okamoto K , et al. (2018)
Developmental profile Size/growth No change Body weight measurement 4-6 weeks Okamoto K , et al. (2018)
Emotion Exploratory activity No change Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Immune response - Not reported - - Okamoto K , et al. (2018)
Learning & memory - Not reported - - Okamoto K , et al. (2018)
Maternal behavior - Not reported - - Okamoto K , et al. (2018)
Molecular profile Protein localization: synapse Decreased Immunohistochemistry 4-6 weeks Okamoto K , et al. (2018)
Motor phenotype - Not reported - - Okamoto K , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Okamoto K , et al. (2018)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents Increased Whole-cell patch clamp 4-6 weeks Okamoto K , et al. (2018)
Neurophysiology Spontaneous post synaptic event frequency: excitatory currents Increased Whole-cell patch clamp 4-6 weeks Okamoto K , et al. (2018)
Physiological parameters - Not reported - - Okamoto K , et al. (2018)
Repetitive behavior - Not reported - - Okamoto K , et al. (2018)
Seizure - Not reported - - Okamoto K , et al. (2018)
Sensory - Not reported - - Okamoto K , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response - Not reported - - Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 2-3 months Horvth G , et al. (2019)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 2-3 months Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry Adult Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Abnormal Electron microscopy Adult Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior Repetitive digging Increased Marble-burying test 2-3 months Horvth G , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 2-3 months Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 2-3 months Horvth G , et al. (2019)
Neurophysiology Synaptic transmission: excitatory No change Whole-cell patch clamp - -
Neurophysiology Synaptic transmission: inhibitory Decreased Whole-cell patch clamp - -
Physiological parameters Respiratory function Decreased Respiration rate and pattern analysis - -

M_POLYIC_10_IN_B_CLONAZEPAM

Model Source:

University of Tokyo

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

6 week old male offsprings with prenatal exposure to polyIC and implanted with electrodes were infused bilaterally with 0.5 microL 500nM clonazepam in DMSO and PBS in the anterior cingulate cortex, immediately before testing.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Okamoto K , et al. (2018)
Communications - Not reported - - Okamoto K , et al. (2018)
Developmental profile Size/growth No adverse effect Body weight measurement 4-6 weeks Okamoto K , et al. (2018)
Emotion Exploratory activity No adverse effect Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)
Immune response - Not reported - - Okamoto K , et al. (2018)
Learning & memory - Not reported - - Okamoto K , et al. (2018)
Maternal behavior - Not reported - - Okamoto K , et al. (2018)
Molecular profile - Not reported - - Okamoto K , et al. (2018)
Motor phenotype - Not reported - - Okamoto K , et al. (2018)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Okamoto K , et al. (2018)
Neurophysiology - Not reported - - Okamoto K , et al. (2018)
Physiological parameters - Not reported - - Okamoto K , et al. (2018)
Repetitive behavior - Not reported - - Okamoto K , et al. (2018)
Seizure - Not reported - - Okamoto K , et al. (2018)
Sensory - Not reported - - Okamoto K , et al. (2018)
Social behavior Social approach Restored Three-chamber social approach test 4-6 weeks Okamoto K , et al. (2018)

M_POLYIC_10_IN_B_JNJ47965567-1

Model Source:

27824163; 11016935

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

P2rx7 wildtype offspring of PolyIC treated (as in parent model M_POLYIC_10_IN_B) wildtype pregnant female mice were treated with 30mg/kg JNJ47965567 dissolved in 30% captisol solution, sulfobutyl ether-7 beta cyclodextrin to increase permeability through the blood brain barrier. Prenatal administration was performed 2 hours before each PolyIC injection at E12.5 and E17.5. Controls were injected with vehicle.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response - Not reported - - Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype Motor coordination and balance Restored Accelerating rotarod test 2-3 months Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Restored Immunohistochemistry 2-3 months Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Restored Electron microscopy 2-3 months Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior Repetitive digging Restored Marble-burying test 2-3 months Horvth G , et al. (2019)
Repetitive behavior Self grooming: perseveration Restored Grooming behavior assessments 2-3 months Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior Social approach Ameliorated Three-chamber social approach test 2-3 months Horvth G , et al. (2019)

M_POLYIC_10_IN_B_JNJ47965567-2

Model Source:

27824163; 11016935

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

2 month old adult M_POLYIC_10_IN_B offspring were treated with 30mg/kg JNJ47965567 dissolved in 30% captisol solution, sulfobutyl ether-7 beta cyclodextrin to increase permeability through the blood brain barrier, with a single i.p. injection on the day of the behavioral test. Controls were injected with vehicle.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response - Not reported - - Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype Motor coordination and balance Restored Accelerating rotarod test Adult Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Restored Immunohistochemistry Adult Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Restored Electron microscopy Adult Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Horvth G , et al. (2019)
Repetitive behavior Self grooming: perseveration Restored Grooming behavior assessments Adult Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior Social approach Restored Three-chamber social approach test Adult Horvth G , et al. (2019)

M_POLYIC_10_IN_B_P2RX7_KO

Model Source:

27824163; 11016935

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

P2rx7 wildtype (control) and null pregnant females were treated with PolyIC as per the M_POLYIC_10_IN_B model. The targeting vector was inserted at Arg^505 codon, deleting from Cys^506 to Pro^532, in the carboxyl-terminal domain of the P2X7R gene product.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response - Not reported - - Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Open field test 2-3 months Horvth G , et al. (2019)
Motor phenotype Motor coordination and balance Restored Accelerating rotarod test 2-3 months Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Refractory Immunohistochemistry Adult Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Refractory Electron microscopy Adult Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior Repetitive digging Restored Marble-burying test 2-3 months Horvth G , et al. (2019)
Repetitive behavior Self grooming: perseveration Restored Grooming behavior assessments 2-3 months Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior Social approach Restored Three-chamber social approach test 2-3 months Horvth G , et al. (2019)

M_POLYIC_10_IN_B_SURAMIN

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

M_POLYIC_10_IN_B offsprings received weekly intraperitoneal administration of 10 or 20 mg/kg of suramin dissolved in saline starting at 6 weeks of age with behavioral testing starting at 8 weeks. Male offsprings were sacrificed at 16 weeks for neuroanatomical and hematological studies.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Naviaux RK , et al. (2013)
Communications - Not reported - - Naviaux RK , et al. (2013)
Developmental profile Size/growth No adverse effect Body length measurement 14 weeks Naviaux RK , et al. (2013)
Developmental profile Size/growth No adverse effect Body weight measurement 14 weeks Naviaux RK , et al. (2013)
Emotion - Not reported - - Naviaux RK , et al. (2013)
Immune response - Not reported - - Naviaux RK , et al. (2013)
Learning & memory - Not reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not reported - - Naviaux RK , et al. (2013)
Molecular profile - Not reported - - Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance Restored Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Naviaux RK , et al. (2013)
Neurophysiology - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Restored Body temperature measurement 8-16 weeks Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Refractory Body temperature measurement 5 months Naviaux RK , et al. (2013)
Physiological parameters Hormone levels No adverse effect Radioimmunoassay (ria) 15 weeks Naviaux RK , et al. (2013)
Physiological parameters Hormone levels Side effect Radioimmunoassay (ria) 15 weeks Naviaux RK , et al. (2013)
Physiological parameters Respiratory function Side effect Respiration rate and pattern analysis Not reported Naviaux RK , et al. (2013)
Physiological parameters Respiratory function Restored Respiration rate and pattern analysis - Naviaux RK , et al. (2013)
Repetitive behavior - Not reported - - Naviaux RK , et al. (2013)
Seizure - Not reported - - Naviaux RK , et al. (2013)
Sensory - Not reported - - Naviaux RK , et al. (2013)
Social behavior Social approach Restored Three-chamber social approach test 8 weeks Naviaux RK , et al. (2013)

M_POLYIC_11_IN_B

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5, the authors note that C57BL/6 mice used were of a stable immunological phenotype as they used these mice to study cytokine levels, therefore these are probably a substrain sold by Taconic. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams. This model is also used in PMID#28902835. Authors of PMID#28902835 specify that all animals used in this study were also from mouse colonies carrying SFB (segmented filamentous bacteria).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile Size/growth No change Body weight measurement 3-3.7 months Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: anti-inflammatory No change Elisa E14.5 Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Increased Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile Gene expression Increased In situ hybridization (ish) E14.5 Choi GB , et al. (2016)
Molecular profile Marker expression Decreased Immunohistochemistry E14.5, E18.5, adult Choi GB , et al. (2016)
Motor phenotype General locomotor activity No change Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Decreased Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness No change Immunohistochemistry E18.5 Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Physiological parameters Reproductive function No change General observations 3-3.7 months Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Decreased Three-chamber social approach test Adult Choi GB , et al. (2016)
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Increased Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile Protein expression: in situ protein expression Increased Immunohistochemistry E14.5 Shin Yim Y , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp Adult Shin Yim Y , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp Adult Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Emotion Exploratory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)

M_POLYIC_11_IN_B

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5, the authors note that C57BL/6 mice used were of a stable immunological phenotype as they used these mice to study cytokine levels, therefore these are probably a substrain sold by Taconic. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams. This model is also used in PMID#28902835. Authors of PMID#28902835 specify that all animals used in this study were also from mouse colonies carrying SFB (segmented filamentous bacteria).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile Size/growth No change Body weight measurement 3-3.7 months Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: anti-inflammatory No change Elisa E14.5 Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Increased Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile Gene expression Increased In situ hybridization (ish) E14.5 Choi GB , et al. (2016)
Molecular profile Marker expression Decreased Immunohistochemistry E14.5, E18.5, adult Choi GB , et al. (2016)
Motor phenotype General locomotor activity No change Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Decreased Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness No change Immunohistochemistry E18.5 Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Physiological parameters Reproductive function No change General observations 3-3.7 months Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Decreased Three-chamber social approach test Adult Choi GB , et al. (2016)
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Increased Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile Protein expression: in situ protein expression Increased Immunohistochemistry E14.5 Shin Yim Y , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp Adult Shin Yim Y , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp Adult Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Emotion Exploratory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)

M_POLYIC_11_IN_B

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5, the authors note that C57BL/6 mice used were of a stable immunological phenotype as they used these mice to study cytokine levels, therefore these are probably a substrain sold by Taconic. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams. This model is also used in PMID#28902835. Authors of PMID#28902835 specify that all animals used in this study were also from mouse colonies carrying SFB (segmented filamentous bacteria).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile Size/growth No change Body weight measurement 3-3.7 months Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: anti-inflammatory No change Elisa E14.5 Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Increased Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile Gene expression Increased In situ hybridization (ish) E14.5 Choi GB , et al. (2016)
Molecular profile Marker expression Decreased Immunohistochemistry E14.5, E18.5, adult Choi GB , et al. (2016)
Motor phenotype General locomotor activity No change Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Decreased Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness No change Immunohistochemistry E18.5 Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Physiological parameters Reproductive function No change General observations 3-3.7 months Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Decreased Three-chamber social approach test Adult Choi GB , et al. (2016)
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Increased Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile Protein expression: in situ protein expression Increased Immunohistochemistry E14.5 Shin Yim Y , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Decreased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp Adult Shin Yim Y , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp Adult Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Emotion Exploratory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)

M_POLYIC_11_IN_B_ANTI-IL17A

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Pretreatment with monoclonal anti-IL17a (IL-17 a blocking antibody) at 500 microg/ animal(i.p.), 6 hrs prior to administration for PolyI:C. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile Size/growth No adverse effect Body weight measurement 3-3.7 months Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: anti-inflammatory No adverse effect Elisa E14.5 Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Restored Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype General locomotor activity No adverse effect Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Restored Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Physiological parameters Reproductive function No adverse effect General observations Adult Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Restored Three-chamber social approach test Adult Choi GB , et al. (2016)

M_POLYIC_11_IN_B_ANTI-IL17A-2

Model Source:

-

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

Administration of PolyI:C on E12.5, followed by treatment with monoclonal anti-IL17a (IL-17 a blocking antibody) at 500 ug/ animal(i.p.) at E14.5. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Ameliorated Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response - Not reported - - Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype General locomotor activity No adverse effect Three-chamber social approach test - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Ameliorated Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Refractory Three-chamber social approach test Adult Choi GB , et al. (2016)

M_POLYIC_11_IN_B_IL17RA_CKO_HM

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 in mice with interleukin 17 receptor a (Il17ra) conditionally knocked out in neural tissue, with one Il17ra null allele and the other floxed Il17ra allele conditionally deleted in nervous tissue using Nestin-Cre.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Restored Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile Targeted expression Side effect Western blot Not reported Shin Yim Y , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Open field test Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Restored Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number Restored Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Restored Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Restored Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_IL17RA_KO_HM

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 in mice with interleukin 17 receptor a (Il17ra) homozygously knocked out. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications - Not reported - - Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response - Not reported - - Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype - Not reported - - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior - Not reported - - Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Restored Three-chamber social approach test 3-3.5 months Choi GB , et al. (2016)

M_POLYIC_11_IN_B_IL17RA_KO_HT

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 in mice with interleukin 17 receptor a (Il17ra) heterozygously knocked out. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications - Not reported - - Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Ameliorated Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype - Not reported - - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior - Not reported - - Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Restored Three-chamber social approach test 3-3.5 months Choi GB , et al. (2016)
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Refractory Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype - Not reported - - Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Refractory Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_IL17RA_KO_HT

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 in mice with interleukin 17 receptor a (Il17ra) heterozygously knocked out. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications - Not reported - - Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Ameliorated Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype - Not reported - - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior - Not reported - - Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Restored Three-chamber social approach test 3-3.5 months Choi GB , et al. (2016)
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Refractory Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype - Not reported - - Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Refractory Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_RORC_CKO_HM

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C at E12.5 to pregnant mice with retinoic acid receptorrelated orphan nuclear receptor gamma t (RORt) conditionally knocked out specifically from CD4+ cells, homozygously. This inhibits the functions of TH17 cells (CD4+RORt+ cells) that express IL-17a and other RORt-expressing T cells, but there is no effect in RORt-expressing innate (or innate-like) immune cells, including T, lymphoid tissue-inducer (LTi) cells, and innate lym-phoid cells type 3 (ILC3). Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Restored Elisa P7-P9 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype General locomotor activity No adverse effect General observations - Choi GB , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Restored Immunohistochemistry E14.5, E18.5 Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Restored Three-chamber social approach test Adult Choi GB , et al. (2016)

M_POLYIC_11_IN_B_RORC_KO_HT

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 in mice with retinoic acid receptorrelated orphan nuclear receptor gamma t (RORt) heterozygously knocked out, this resulted in some levels of RORt still being present in the mothers. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Refractory Monitoring ultrasonic vocalizations P7-P9 Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response - Not reported - - Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype General locomotor activity No adverse effect Three-chamber social approach test Adult Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior Repetitive digging Refractory Marble-burying test Adult Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior Social approach Refractory Three-chamber social approach test Adult Choi GB , et al. (2016)

M_POLYIC_11_IN_B_SFB

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

C57BL/6 mice purchased from Taconic Biosciences that harbor segmented filamentous bacteria in the intestines were intraperitonealy injected with 20mg/kg Poly(I:C) at E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile Size/growth No change Body weight measurement 3 weeks Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels No change Elisa Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile Protein expression level evidence Increased Elisa Adult Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Physiological parameters Reproductive function No change General observations Adult Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)

M_POLYIC_11_IN_B_SSCX-ACT

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Offsprings with prenatal exposure of PolyI:C induced maternal infection at E12.5 and photostimulation of activating channelrhodopsin-expressing-virus in the S1DZ region of the primary somatosensory cortex. Control animals expressed EYFP in the S1DZ region of the primary somatosensory cortex.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype - Not reported - - Shin Yim Y , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Refractory Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Refractory Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Inanimate object preference Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Social behavior Social approach Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_SSCX-INACT

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Offsprings with prenatal exposure of PolyI:C induced maternal infection at E12.5 and photostimulation of inhibitting halorhodopsin-expressing-virus in the S1DZ region of the primary somatosensory cortex. Control animals expressed EYFP in the S1DZ region of the primary somatosensory cortex.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Restored Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype - Not reported - - Shin Yim Y , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Shin Yim Y , et al. (2017)
Neurophysiology Neuronal activation Restored Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Inanimate object preference Restored Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_SSCX-INACT-DS

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Offsprings with prenatal exposure of PolyI:C induced maternal infection at E12.5 and injection of retrogradely transported rabies virus expressing EYFP and the inhibitory opsin ArchT in the dorsal striatum.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Restored Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype - Not reported - - Shin Yim Y , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Shin Yim Y , et al. (2017)
Neurophysiology - Not reported - - Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Inanimate object preference Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)
Social behavior Social approach Refractory Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_SSCX-INACT-TEA

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Offsprings with prenatal exposure of PolyI:C induced maternal infection at E12.5 and injection of retrogradely transported rabies virus expressing EYFP and the inhibitory opsin ArchT in the temporal association cortex (TeA).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications - Not reported - - Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Refractory Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype - Not reported - - Shin Yim Y , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Shin Yim Y , et al. (2017)
Neurophysiology - Not reported - - Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging Refractory Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_11_IN_B_VANCOMYCIN

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Wild-type C57BL/6 mice were treated with the broad spectrum antibiotic vancomycin-hydrocholoride 7, 5 and 3 days before phosphate-buffered saline (control) or 20mg/kg poly(I:C) administration at E12.5. 2.5mg/kg vancomycin was orally gavaged in Taconic-derived female mice to remove intestinal bacteria.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Restored Open field test Adult Kim S , et al. (2017)
Immune response Cytokine levels Restored Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Restored Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)

M_POLYIC_12_IN_B_SFB

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To induce MIA phenotypes, age-matched SFB (segmented filamentous bacteria) positive mice from Taconic Biosciences were introduced into cages with mice purchased from Jackson laboratory that were SFB negative, and cohoused in sterilized cages for two weeks at a ratio of 2:3. Pregnant female mice from Jackson laboratories were then injected intraperitonealy with Poly(I:C) at E12.5 and assayed. In PMID 31853066 matings between Vgat–Cre (c/c) [Slc32a1(Vgat)-Cre (028862, Jackson Laboratories) males and wild-type females from Taconic carrying SFB in their guts were used to generate MIA Vgat–Cre offspring mice. IL17Ra deficient polyI:C exposed controls were generated by crossing Il-17ra^fl/fl [PMID 22951726, El Malki et al, 2013, Il17ra^tm1.1Kurs] conditional ready mice with exons through 7 of interleukin 17 receptor A floxed, with MIA Vgat–Cre offspring mice.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - ()
Communications - Not Reported - - ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response - Not Reported - - ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile - Not Reported - - ()
Motor phenotype General locomotor activity: Ambulatory activity No change Three-chamber social approach test Adult, 2-5 months, 9-12 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - ()
Neurophysiology Action potential firing Increased Electrocorticogram (ECoG) Adult ()
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult, 2-5 months, 9-12 months ()
Repetitive behavior Repetitive digging Increased Marble-burying test Adult, 2-5 months, 9-12 months ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Decreased Three-chamber social approach test Adult, 2-5 months, 9-12 months ()
Social behavior Social interaction Decreased Reciprocal social interaction test Adult, 2-5 months, 9-12 months ()

M_POLYIC_12_IN_B_SFB

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To induce MIA phenotypes, age-matched SFB (segmented filamentous bacteria) positive mice from Taconic Biosciences were introduced into cages with mice purchased from Jackson laboratory that were SFB negative, and cohoused in sterilized cages for two weeks at a ratio of 2:3. Pregnant female mice from Jackson laboratories were then injected intraperitonealy with Poly(I:C) at E12.5 and assayed. In PMID 31853066 matings between Vgat–Cre (c/c) [Slc32a1(Vgat)-Cre (028862, Jackson Laboratories) males and wild-type females from Taconic carrying SFB in their guts were used to generate MIA Vgat–Cre offspring mice. IL17Ra deficient polyI:C exposed controls were generated by crossing Il-17ra^fl/fl [PMID 22951726, El Malki et al, 2013, Il17ra^tm1.1Kurs] conditional ready mice with exons through 7 of interleukin 17 receptor A floxed, with MIA Vgat–Cre offspring mice.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)
Circadian sleep/wake cycle - Not Reported - - ()
Communications - Not Reported - - ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response - Not Reported - - ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile - Not Reported - - ()
Motor phenotype General locomotor activity: Ambulatory activity No change Three-chamber social approach test Adult, 2-5 months, 9-12 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - ()
Neurophysiology Action potential firing Increased Electrocorticogram (ECoG) Adult ()
Neurophysiology Neuronal activation Increased Immunohistochemistry Adult, 2-5 months, 9-12 months ()
Repetitive behavior Repetitive digging Increased Marble-burying test Adult, 2-5 months, 9-12 months ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Decreased Three-chamber social approach test Adult, 2-5 months, 9-12 months ()
Social behavior Social interaction Decreased Reciprocal social interaction test Adult, 2-5 months, 9-12 months ()

M_POLYIC_12_IN_B_SFB_IL17a-S1DZ

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Adult male polyI:C exposed mice were administered recombinant IL17a protein (50 ng per side in 1 microliter at a rate of 180 nl/min, 7956-ML/CF, R&D) directly and bilaterally into the primary somatosensory cortex dysgranular four hours before testing.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - ()
Communications - Not Reported - - ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response - Not Reported - - ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile - Not Reported - - ()
Motor phenotype - Not Reported - - ()
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - ()
Neurophysiology - Not Reported - - ()
Repetitive behavior - Not Reported - - ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Restored Three-chamber social approach test Adult ()

M_POLYIC_12_IN_B_SFB_LPS

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

PolyI:C exposed mice were administered LPS injection (50microgram/kg, i.p., acute)

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - ()
Communications - Not Reported - - ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response Cytokine levels: pro-inflammatory Side effect ELISA Adult, 2-5 months, 9-12 months ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile - Not Reported - - ()
Motor phenotype General locomotor activity: Ambulatory activity No adverse effect Three-chamber social approach test Adult, 2-5 months, 9-12 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - ()
Neurophysiology Action potential firing Restored Electrocorticogram (ECoG) Adult ()
Neurophysiology Neuronal activation Restored Immunohistochemistry Adult, 2-5 months, 9-12 months ()
Physiological parameters Core body temperature No adverse effect Body temperature measurement Adult, 2-5 months, 9-12 months ()
Repetitive behavior Repetitive digging Restored Marble-burying test Adult, 2-5 months, 9-12 months ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Restored Three-chamber social approach test Adult, 2-5 months, 9-12 months ()
Social behavior Social interaction Restored Reciprocal social interaction test Adult, 2-5 months, 9-12 months ()

M_POLYIC_12_IN_B_SFB_LPS-Anti-IL17a

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

PolyI:C exposed mice were administered LPS (50microgram/kg, i.p., acute) and IL17a antibody (i.c.v, right lateral ventricle, clone 50104; R&D or isotype-control antibody IgG2a, clone 54447; R&D).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - ()
Communications - Not Reported - - ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response - Not Reported - - ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile - Not Reported - - ()
Motor phenotype - Not Reported - - ()
Neuroanatomy / Ultrastructure / Cytoarchitecture - Not Reported - - ()
Neurophysiology Action potential firing Refractory Electrocorticogram (ECoG) Adult, 2-5 months, 9-12 months ()
Neurophysiology Neuronal activation Refractory Immunohistochemistry Adult, 2-5 months, 9-12 months ()
Repetitive behavior - Not Reported - - ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Refractory Three-chamber social approach test Adult, 2-5 months, 9-12 months ()

M_POLYIC_13_IN_B_SFB

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To induce MIA phenotypes, four faecal pellets of SFB (segmented filamentous bacteria) mono-colonized mice were dissolved in 20 ml sterile PBS, filtered though a 100-micrometer cell strainer and 200microliter of faecal suspensions were gavaged via oral route to 4-week-old female Jackson mice. Control mice were gavaged with PBS. Pregnant female mice from Jackson laboratories were then injected intraperitonealy with Poly(I:C) at E12.5 and assayed.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test Adult Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 8-12 weeks Kim S , et al. (2017)

M_POLYIC_13_IN_B_SFB_IL17A_KO_HM

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

SFB-colonized CD45.2 positive recipient mice, deficient in IL-17a production, (IL-17a-KO) females, without adoptive transfers of 7B8-Tg-derived CD4+ T cells, were crossed with wild-type C57BL/6 males to produce heterozygous offspring. Pregnant females were intraperitonealy injected with 20mg/kg Poly(I:C) at E12.5. By comparing behavioral phenotypes in the presence and absence of IL-17a the authors sought to investigate whether IL-17a produced by the SFB antigen-specific CD4+ T cells was sufficient to induce MIA phenotypes in offspring.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Ameliorated Open field test 2.1 months Kim S , et al. (2017)
Immune response Cytokine levels Ameliorated Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Three-chamber social approach test 2.1 months Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Restored Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 1.8 months Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 2.1 months Kim S , et al. (2017)

M_POLYIC_13_IN_B_SFB_TRA_KO_HM

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Mice expressing a transgenic T cell receptor (TCR) lacking alphabeta T cells (TCRalpha-KO) at E0. TCR-KO females, without adoptive transfers of 7B8-Tg-derived CD4+ T cells, were crossed with wild-type C57BL/6 males to produce heterozygous offspring. Pregnant females were intraperitonealy injected with 20mg/kg Poly(I:C) at E12.5. By comparing behavioral phenotypes in the presence and absence of TCRalpha that authors sought to investigate whether commensal antigen specific Th17 cells in pregnant mothers were sufficient to induce MIA associated behaviors in the offspring.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Ameliorated Open field test 2.1 months Kim S , et al. (2017)
Immune response - Not reported - - Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Three-chamber social approach test 2.1 months Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 1.8 months Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 2.1 months Kim S , et al. (2017)

M_POLYIC_14_IN_B_SFB_XFOSTER

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 to Tac (SFB-positive) dams. Offspring were cross-fostered with PBS-treated dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test 2.1 months Kim S , et al. (2017)
Immune response - Not reported - - Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test 2.1 months Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test 1.8 months Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 2.1 months Kim S , et al. (2017)

M_POLYIC_15_IN_B_SFB_XFOSTER

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

Administration of PolyI:C on E12.5 to Tac (SFB-positive) dams. Offspring were cross-fostered with Jax (SFB-negative) dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test 2.1 months Kim S , et al. (2017)
Immune response - Not reported - - Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test 2.1 months Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test 1.8 months Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 2.1 months Kim S , et al. (2017)

M_POLYIC_16_IN_B_HGB

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

SFB negative Jax mothers were orally gavaged with a mix of twenty human gut-residing bacterial strains twice, on E3.5 and E10.5, followed by 20mg/kg poly(I:C) injection at E12.5. The mix of twenty human bacterial strains had been previously shown to induce TH17 cells in the large intestines of mice.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Increased Open field test 2.1 months Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test 2.1 months Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Physiological parameters Intestinal microbiota composition Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test 1.8 months Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 2.1 months Kim S , et al. (2017)

M_POLYIC_16_IN_B_HGB_ANTI-IL17A

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

SFB negative Jax mothers were orally gavaged with a mix of twenty human gut-residing bacterial strains twice, on E3.5 and E10.5, followed by 20mg/kg poly(I:C) injection at E12.5. The mix of twenty human bacterial strains had been previously shown to induce TH17 cells in the large intestines of mice. Mothers were pre-treated with IL-17a-blocking antibody 8 hours prior to PolyI:C treatment.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Restored Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Restored Open field test 2.1 months Kim S , et al. (2017)
Immune response Cytokine levels Restored Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No adverse effect Three-chamber social approach test 2.1 months Kim S , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Restored Immunohistochemistry Adult Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Restored Marble-burying test 1.8 months Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Restored Three-chamber social approach test 2.1 months Kim S , et al. (2017)

M_POLYIC_17_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

Administration of PolyI:C on E9 to pregnant mice.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Canetta S , et al. (2016)
Communications - Not reported - - Canetta S , et al. (2016)
Developmental profile - Not reported - - Canetta S , et al. (2016)
Emotion Anxiety Increased Elevated plus maze test Adult Canetta S , et al. (2016)
Immune response - Not reported - - Canetta S , et al. (2016)
Learning & memory Cognitive flexibility: associative learning Decreased Set-shifting task 3-3.3 months Canetta S , et al. (2016)
Learning & memory Reward reinforced choice behavior No change Delayed non-match to sample t-maze test 3-3.3 months Canetta S , et al. (2016)
Learning & memory Reward reinforced choice behavior No change Operant conditioning paradigm 3-3.3 months Canetta S , et al. (2016)
Maternal behavior - Not reported - - Canetta S , et al. (2016)
Molecular profile Protein expression level evidence Decreased Immunohistochemistry - Canetta S , et al. (2016)
Motor phenotype - Not reported - - Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: interneurons No change Stereology Adult Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory No change Immunohistochemistry Adult Canetta S , et al. (2016)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology No change Immunohistochemistry Adult Canetta S , et al. (2016)
Neurophysiology Event related oscillations (eros) in electroencephalography (eeg) Decreased Electroencephalogram (eeg) Adult Canetta S , et al. (2016)
Neurophysiology Intrinsic membrane properties Increased Whole-cell patch clamp Adult Canetta S , et al. (2016)
Neurophysiology Intrinsic membrane properties No change Whole-cell patch clamp Adult Canetta S , et al. (2016)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 3-3.3 months Canetta S , et al. (2016)
Neurophysiology Miniature post synaptic current frequency: inhibitory Decreased Whole-cell patch clamp Adult Canetta S , et al. (2016)
Neurophysiology Spontaneous post synaptic event amplitude: inhibitory currents Decreased Whole-cell patch clamp 3-3.3 months Canetta S , et al. (2016)
Neurophysiology Spontaneous post synaptic event frequency: inhibitory currents Decreased Whole-cell patch clamp 3-3.3 months Canetta S , et al. (2016)
Physiological parameters - Not reported - - Canetta S , et al. (2016)
Repetitive behavior - Not reported - - Canetta S , et al. (2016)
Seizure - Not reported - - Canetta S , et al. (2016)
Sensory - Not reported - - Canetta S , et al. (2016)
Social behavior - Not reported - - Canetta S , et al. (2016)

M_POLYIC_17_IN_B_PVALB-CHR2

Model Source:

Kallendonk laboratory, Columbia University Medical Center (PMID 26830140)

Model Type:

Induced

Strain of Origin:

129S6/SvEvTac * C57BL/6NCrl*129P2/OlaHsd

Construct Definition:

Administration of PolyI:C on E9 to pregnant mice with the background of parvalbumin-Cre bred to channel rhodopsin2-YFP flox stop reporter line, resulting in channel rhodopsin being expressed in the parvalbumin positive neurons. This line was used to measure the functional GABAergic connectivity between populations of prefrontal parvalbumin expressing interneurons with their post synaptic pyramidal cell targets.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Canetta S , et al. (2016)
Communications - Not reported - - Canetta S , et al. (2016)
Developmental profile - Not reported - - Canetta S , et al. (2016)
Emotion - Not reported - - Canetta S , et al. (2016)
Immune response - Not reported - - Canetta S , et al. (2016)
Learning & memory - Not reported - - Canetta S , et al. (2016)
Maternal behavior - Not reported - - Canetta S , et al. (2016)
Molecular profile - Not reported - - Canetta S , et al. (2016)
Motor phenotype - Not reported - - Canetta S , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Canetta S , et al. (2016)
Neurophysiology Presynaptic function: paired-pulse facilitation Decreased Optogenetics 3-3.3 months Canetta S , et al. (2016)
Neurophysiology Synaptic transmission: inhibitory Decreased Optogenetics 3-3.3 months Canetta S , et al. (2016)
Physiological parameters - Not reported - - Canetta S , et al. (2016)
Repetitive behavior - Not reported - - Canetta S , et al. (2016)
Seizure - Not reported - - Canetta S , et al. (2016)
Sensory - Not reported - - Canetta S , et al. (2016)
Social behavior - Not reported - - Canetta S , et al. (2016)

M_POLYIC_18_IN_B

Model Source:

Japan SLC, Inc.

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

At embryonic day 12.5 pregnant dams were intraperitoneally injected with poly I:C (20 mg/kg; Sigma-Aldrich, USA), or equivalent amount of saline in controls.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Lim JS , et al. (2017)
Communications - Not reported - - Lim JS , et al. (2017)
Developmental profile - Not reported - - Lim JS , et al. (2017)
Emotion Anxiety Increased Open field test 6 weeks Lim JS , et al. (2017)
Immune response - Not reported - - Lim JS , et al. (2017)
Learning & memory - Not reported - - Lim JS , et al. (2017)
Maternal behavior - Not reported - - Lim JS , et al. (2017)
Molecular profile - Not reported - - Lim JS , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 6 weeks Lim JS , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Lim JS , et al. (2017)
Physiological parameters - Not reported - - Lim JS , et al. (2017)
Physiological parameters Bioactive compound levels: serotonin Increased Elisa 6 weeks Lim JS , et al. (2017)
Physiological parameters Intestinal microbiota composition: overall microbiota composition No change 16s rrna gene sequence analysis for identification of bacteria 3, 4, 5 weeks Lim JS , et al. (2017)
Physiological parameters Intestinal microbiota composition: species diversity Abnormal 16s rrna gene sequence analysis for identification of bacteria 3 weeks Lim JS , et al. (2017)
Repetitive behavior - Not reported - - Lim JS , et al. (2017)
Seizure - Not reported - - Lim JS , et al. (2017)
Sensory - Not reported - - Lim JS , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks Lim JS , et al. (2017)
Social behavior Social memory Decreased Three-chamber social approach test 6 weeks Lim JS , et al. (2017)

M_POLYIC_19_IN_B

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

At embryonic day 15.5 pregnant females were intraperitoneally injected with 20mg/kg PolyI:C, to determine the effect of poly(I:C) administration at a different time point during pregnancy. Authors of PMID#28902835 specify that all animals used in this study were also from mouse colonies carrying SFB (segmented filamentous bacteria).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety Increased Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches Increased Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology - Not reported - - Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging No change Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_1_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E9 and E17 in 5 ml/kg.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Li Q , et al. (2009)
Communications - Not reported - - Li Q , et al. (2009)
Developmental profile - Not reported - - Li Q , et al. (2009)
Emotion - Not reported - - Li Q , et al. (2009)
Immune response - Not reported - - Li Q , et al. (2009)
Learning & memory - Not reported - - Li Q , et al. (2009)
Maternal behavior - Not reported - - Li Q , et al. (2009)
Molecular profile - Not reported - - Li Q , et al. (2009)
Motor phenotype - Not reported - - Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neurophysiology - Not reported - - Li Q , et al. (2009)
Physiological parameters - Not reported - - Li Q , et al. (2009)
Repetitive behavior - Not reported - - Li Q , et al. (2009)
Seizure - Not reported - - Li Q , et al. (2009)
Sensory Sensorimotor gating Abnormal Prepulse inhibition 12 weeks Li Q , et al. (2009)
Social behavior - Not reported - - Li Q , et al. (2009)

M_POLYIC_20_IN_B

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

At embryonic day 18.5 pregnant females were intraperitoneally injected with 20mg/kg PolyI:C, to determine the effect of poly(I:C) administration at a different time point during pregnancy. Authors of PMID#28902835 specify that all animals used in this study were also from mouse colonies carrying SFB (segmented filamentous bacteria).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shin Yim Y , et al. (2017)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Shin Yim Y , et al. (2017)
Developmental profile - Not reported - - Shin Yim Y , et al. (2017)
Emotion Anxiety No change Open field test Adult Shin Yim Y , et al. (2017)
Immune response - Not reported - - Shin Yim Y , et al. (2017)
Learning & memory - Not reported - - Shin Yim Y , et al. (2017)
Maternal behavior - Not reported - - Shin Yim Y , et al. (2017)
Molecular profile - Not reported - - Shin Yim Y , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test Adult Shin Yim Y , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture: cortical patches No change Immunohistochemistry Adult Shin Yim Y , et al. (2017)
Neurophysiology - Not reported - - Shin Yim Y , et al. (2017)
Physiological parameters - Not reported - - Shin Yim Y , et al. (2017)
Repetitive behavior Repetitive digging No change Marble-burying test Adult Shin Yim Y , et al. (2017)
Seizure - Not reported - - Shin Yim Y , et al. (2017)
Sensory - Not reported - - Shin Yim Y , et al. (2017)
Social behavior Social approach No change Three-chamber social approach test Adult Shin Yim Y , et al. (2017)

M_POLYIC_21_IN_B_LMONOCYTOGENES

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To investigate whether individual human commensal bacteria that have been reported to promote differentiation of intestinal TH17 cells induced MIA associated phenotypes in offsprings of PolyI:C treated mothers, SFB negative pregnant Jax females were gavaged with Listeria monocytogenes.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion - Not reported - - Kim S , et al. (2017)
Immune response Adaptive immune response: t cells No change Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Immune response Cytokine levels No change Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Physiological parameters Intestinal microbiota composition No change Quantitative pcr (qrt-pcr) Adult Kim S , et al. (2017)
Repetitive behavior - Not reported - - Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior - Not reported - - Kim S , et al. (2017)

M_POLYIC_22_IN_B_BFRAGILIS

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To investigate whether individual human commensal bacteria that have been reported to promote differentiation of intestinal TH17 cells induced MIA associated phenotypes in offsprings of PolyIC treated mothers, SFB negative pregnant Jax females were gavaged with Bacteroides fragilis.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion - Not reported - - Kim S , et al. (2017)
Immune response Adaptive immune response: t cells No change Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels No change Elisa Adult Kim S , et al. (2017)
Immune response Cytokine levels No change Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Physiological parameters Intestinal microbiota composition No change Quantitative pcr (qrt-pcr) Adult Kim S , et al. (2017)
Repetitive behavior - Not reported - - Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior - Not reported - - Kim S , et al. (2017)

M_POLYIC_23_IN_B_BADOLESCENTIS

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To investigate whether individual human commensal bacteria that have been reported to promote differentiation of intestinal TH17 cells induced MIA associated phenotypes in offsprings of PolyIC treated mothers, SFB negative pregnant Jax females were gavaged with Bifidobacterium adolescentis.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion - Not reported - - Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Immune response Cytokine levels No change Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Physiological parameters Intestinal microbiota composition No change Quantitative pcr (qrt-pcr) Adult Kim S , et al. (2017)
Repetitive behavior - Not reported - - Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior - Not reported - - Kim S , et al. (2017)

M_POLYIC_24_IN_B_ECOLI

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

To investigate whether individual human commensal bacteria that have been reported to promote differentiation of intestinal TH17 cells induced MIA associated phenotypes in offsprings of PolyIC treated mothers, SFB negative pregnant Jax females were gavaged with adherent Escherichia coli isolate, CD-SpA 2A.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion - Not reported - - Kim S , et al. (2017)
Immune response Adaptive immune response: t cells Increased Flow cytometric analysis Adult Kim S , et al. (2017)
Immune response Cytokine levels Increased Elisa Adult Kim S , et al. (2017)
Immune response Cytokine levels No change Elisa Adult Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype - Not reported - - Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Physiological parameters Intestinal microbiota composition No change Quantitative pcr (qrt-pcr) Adult Kim S , et al. (2017)
Repetitive behavior - Not reported - - Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior - Not reported - - Kim S , et al. (2017)

M_POLYIC_25_IN_B_SFB_TCT_IL17A_KO_HM

Model Source:

Taconic, USA

Model Type:

Induced

Strain of Origin:

C56BL/6NTac

Construct Definition:

IL17A homozygous knockout mice with segmented filamentous bacteria in the gut that received 7B8 transgenic T cells treated with PolyI:C. Pregnant females were intraperitonealy injected with 20mg/kg Poly(I:C) at E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Kim S , et al. (2017)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations P9 Kim S , et al. (2017)
Developmental profile - Not reported - - Kim S , et al. (2017)
Emotion Anxiety Decreased Open field test Adult Kim S , et al. (2017)
Immune response - Not reported - - Kim S , et al. (2017)
Learning & memory - Not reported - - Kim S , et al. (2017)
Maternal behavior - Not reported - - Kim S , et al. (2017)
Molecular profile - Not reported - - Kim S , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity No change Three-chamber social approach test Adult Kim S , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Kim S , et al. (2017)
Neurophysiology - Not reported - - Kim S , et al. (2017)
Physiological parameters - Not reported - - Kim S , et al. (2017)
Repetitive behavior Repetitive digging Increased Marble-burying test Adult Kim S , et al. (2017)
Seizure - Not reported - - Kim S , et al. (2017)
Sensory - Not reported - - Kim S , et al. (2017)
Social behavior Social approach Decreased Three-chamber social approach test Adult Kim S , et al. (2017)

M_POLYIC_26_IN_B

Model Source:

-

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

Pregnant dams were injected intraperitoneally at gestational day 9 with polyinosinic:polycytidylic acid, at the beginning of cortical neuronal layering.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Corradini I , et al. (2017)
Communications - Not reported - - Corradini I , et al. (2017)
Developmental profile - Not reported - - Corradini I , et al. (2017)
Emotion - Not reported - - Corradini I , et al. (2017)
Immune response Cns inflammation No change Confocal microscopy 3 months Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory Increased Quantitative pcr (qrt-pcr) Adult Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory Increased Quantitative pcr (qrt-pcr) E9-10 Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory No change Quantitative pcr (qrt-pcr) 2.8 weeks Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory No change Quantitative pcr (qrt-pcr) E9-10 Corradini I , et al. (2017)
Learning & memory - Not reported - - Corradini I , et al. (2017)
Maternal behavior - Not reported - - Corradini I , et al. (2017)
Molecular profile Protein-dna complex assembly Increased Quantitative pcr (qrt-pcr) 2.8 weeks Corradini I , et al. (2017)
Motor phenotype Hyperactivity Increased General observations Not reported Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture Neuronal differentiation and specification in the brain Decreased Quantitative pcr (qrt-pcr) 2.8 weeks Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture Neuronal differentiation and specification in the brain No change Quantitative pcr (qrt-pcr) 2.8 weeks Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture Neuronal differentiation and specification in the brain No change Western blot 3 months Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture Neuronal differentiation and specification in the brain Decreased Western blot E17, 3 months Corradini I , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory No change Western blot 2.4, 2.8 weeks and 3 months Corradini I , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: inhibitory No change Western blot 2.4, 2.8 weeks and 3 months Corradini I , et al. (2017)
Neurophysiology Action potential firing Increased Cell-attached patch clamp 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Driving force of ion channel or receptor Increased Immunofluorescence staining 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Ion influx and permeability: chlorine Increased Immunofluorescence staining 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: excitatory No change Cell-attached patch clamp 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Cell-attached patch clamp 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: excitatory No change Cell-attached patch clamp 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Miniature post synaptic current frequency: inhibitory No change Cell-attached patch clamp 2.8 weeks Corradini I , et al. (2017)
Neurophysiology Neuroreceptor activity: gabaa excitatory-inhibitory switch Decreased Cell-attached patch clamp Not reported Corradini I , et al. (2017)
Physiological parameters - Not reported - - Corradini I , et al. (2017)
Repetitive behavior - Not reported - - Corradini I , et al. (2017)
Seizure Seizure threshold Decreased Observation of chemically induced seizures 3 months Corradini I , et al. (2017)
Seizure Seizures No change General observations 0-3 months Corradini I , et al. (2017)
Sensory - Not reported - - Corradini I , et al. (2017)
Social behavior - Not reported - - Corradini I , et al. (2017)

M_POLYIC_26_IN_B_ILR1_KO

Model Source:

Glaccum MB, Stocking KL, Charrier K, Smith JL, Willis CR,

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

PolyI:C injection in IL-1RI KO pregnant dams at E9. .

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Corradini I , et al. (2017)
Communications - Not reported - - Corradini I , et al. (2017)
Developmental profile - Not reported - - Corradini I , et al. (2017)
Emotion - Not reported - - Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory Restored Quantitative pcr (qrt-pcr) E9-10 Corradini I , et al. (2017)
Learning & memory - Not reported - - Corradini I , et al. (2017)
Maternal behavior - Not reported - - Corradini I , et al. (2017)
Molecular profile - Not reported - - Corradini I , et al. (2017)
Motor phenotype - Not reported - - Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Corradini I , et al. (2017)
Neurophysiology - Not reported - - Corradini I , et al. (2017)
Physiological parameters - Not reported - - Corradini I , et al. (2017)
Repetitive behavior - Not reported - - Corradini I , et al. (2017)
Seizure - Not reported - - Corradini I , et al. (2017)
Sensory - Not reported - - Corradini I , et al. (2017)
Social behavior - Not reported - - Corradini I , et al. (2017)

M_POLYIC_26_IN_B_ILR1_KO-EMB_WT-DAM

Model Source:

Glaccum MB, Stocking KL, Charrier K, Smith JL, Willis CR,

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

Embryos from interleukin-1 receptor type I knockout (IL-1RI KO) female mice were implanted into wild-type (WT) pseudopregnant female mice. In IL-1RI KO mice the immune response is subjected to a brake that tunes down the inflammatory process. Pregnant dams were injected intraperitoneally at gestational day 9 with polyinosinic:polycytidylic acid, at the beginning of cortical neuronal layering.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Corradini I , et al. (2017)
Communications - Not reported - - Corradini I , et al. (2017)
Developmental profile - Not reported - - Corradini I , et al. (2017)
Emotion - Not reported - - Corradini I , et al. (2017)
Immune response - Not reported - - Corradini I , et al. (2017)
Learning & memory - Not reported - - Corradini I , et al. (2017)
Maternal behavior - Not reported - - Corradini I , et al. (2017)
Molecular profile - Not reported - - Corradini I , et al. (2017)
Motor phenotype - Not reported - - Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture Neuronal differentiation and specification in the brain Refractory Quantitative pcr (qrt-pcr) 3 months Corradini I , et al. (2017)
Neurophysiology - Not reported - - Corradini I , et al. (2017)
Physiological parameters - Not reported - - Corradini I , et al. (2017)
Repetitive behavior - Not reported - - Corradini I , et al. (2017)
Seizure - Not reported - - Corradini I , et al. (2017)
Sensory - Not reported - - Corradini I , et al. (2017)
Social behavior - Not reported - - Corradini I , et al. (2017)

M_POLYIC_26_IN_B_MGSO4

Model Source:

Sugimoto J, Romani AM, Valentin-Torres AM, Luciano AA, Ramirez Kitchen CM, Funderburg N, et al. (2012): Magnesium decreases inflammatory cytokine production: A novel innate immunomodulatory mechanism. J Immunol 188:63386346 (PMID:22611240)

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

Preganant dams were treated with magnesium sulfate (MgSO4) before PolyI:C injection at embryonic day 9. Magnesium acts as an immunomodulator that is able to decrease inflammatory cytokine production.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Corradini I , et al. (2017)
Communications - Not reported - - Corradini I , et al. (2017)
Developmental profile - Not reported - - Corradini I , et al. (2017)
Emotion - Not reported - - Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory Restored Quantitative pcr (qrt-pcr) 2.8 weeks Corradini I , et al. (2017)
Immune response Cytokine levels: pro-inflammatory Restored Quantitative pcr (qrt-pcr) Adult Corradini I , et al. (2017)
Learning & memory - Not reported - - Corradini I , et al. (2017)
Maternal behavior - Not reported - - Corradini I , et al. (2017)
Molecular profile - Not reported - - Corradini I , et al. (2017)
Motor phenotype - Not reported - - Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture Neuronal differentiation and specification in the brain Restored Quantitative pcr (qrt-pcr) E17 and 3months Corradini I , et al. (2017)
Neurophysiology Ion influx and permeability: chlorine Restored Immunofluorescence staining 2.8 weeks Corradini I , et al. (2017)
Physiological parameters - Not reported - - Corradini I , et al. (2017)
Repetitive behavior - Not reported - - Corradini I , et al. (2017)
Seizure Seizure threshold Restored Observation of chemically induced seizures 3 months Corradini I , et al. (2017)
Sensory - Not reported - - Corradini I , et al. (2017)
Social behavior - Not reported - - Corradini I , et al. (2017)

M_POLYIC_27_IN_B

Model Source:

-

Model Type:

Induced

Strain of Origin:

C57BL/6

Construct Definition:

Adult mice were injected intraperitoneally with a single dose of polyIC. .

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Corradini I , et al. (2017)
Communications - Not reported - - Corradini I , et al. (2017)
Developmental profile - Not reported - - Corradini I , et al. (2017)
Emotion - Not reported - - Corradini I , et al. (2017)
Immune response - Not reported - - Corradini I , et al. (2017)
Learning & memory - Not reported - - Corradini I , et al. (2017)
Maternal behavior - Not reported - - Corradini I , et al. (2017)
Molecular profile - Not reported - - Corradini I , et al. (2017)
Motor phenotype - Not reported - - Corradini I , et al. (2017)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Corradini I , et al. (2017)
Neurophysiology - Not reported - - Corradini I , et al. (2017)
Physiological parameters - Not reported - - Corradini I , et al. (2017)
Repetitive behavior - Not reported - - Corradini I , et al. (2017)
Seizure Seizure threshold No change Observation of chemically induced seizures 0-3 months Corradini I , et al. (2017)
Seizure Seizures No change General observations 0-3 months Corradini I , et al. (2017)
Sensory - Not reported - - Corradini I , et al. (2017)
Social behavior - Not reported - - Corradini I , et al. (2017)

M_POLYIC_28_IN_B

Model Source:

Harlan (Bicester, UK).

Model Type:

Induced

Strain of Origin:

NIH Swiss

Construct Definition:

Pregnant females were injected intraperitoneally with a single dose of polyIC or saline (controls). All pups remained with the mother until weaning at postnatal day 21, when male mice were housed in same-sex littermate groups containing three to four mice.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response Increased Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety Decreased Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Depression Increased Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing Decreased General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin Decreased Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability Increased Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging No change Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference No change Social transmission of food preference 12 weeks Morais LH , et al. (2018)

M_POLYIC_29_IN_B

Model Source:

27824163; 11016935

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant primiparous dams received a single intraperitoneal injection of PolyIC at a dose of 3mg/kg on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response Cytokine levels: anti-inflammatory No change Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Immune response Cytokine levels: pro-inflammatory Increased Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Immune response Cytokine levels: pro-inflammatory No change Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Motor phenotype - Not reported - - Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Decreased Immunofluorescence staining E14.5 Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Physiological parameters Bioactive compound levels Decreased High-performance liquid chromatography (hplc) E15 Horvth G , et al. (2019)
Physiological parameters Bioactive compound levels Increased High-performance liquid chromatography (hplc) Adult, E15 Horvth G , et al. (2019)
Physiological parameters Bioactive compound levels No change High-performance liquid chromatography (hplc) Adult, E15 Horvth G , et al. (2019)
Repetitive behavior - Not reported - - Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior - Not reported - - Horvth G , et al. (2019)

M_POLYIC_29_IN_B_JNJ47965567

Model Source:

27824163; 11016935

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant primiparous dams received a single intraperitoneal injection of PolyIC at a dose of 3mg/kg and 30mg/kg JNJ47965567 dissolved in 30% captisol solution, sulfobutyl ether-7 beta cyclodextrin to increase permeability through the blood brain barrier at E12.5. JNJ47965567 was injected 2hours prior to PolyIC. Controls were injected with vehicle.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response Cytokine levels: anti-inflammatory No adverse effect Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Immune response Cytokine levels: pro-inflammatory Restored Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Immune response Cytokine levels: pro-inflammatory No adverse effect Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype - Not reported - - Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Restored Immunofluorescence staining E14.5 Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior - Not reported - - Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior - Not reported - - Horvth G , et al. (2019)

M_POLYIC_29_IN_B_P2RX7_KO

Model Source:

27824163; 11016935

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

P2rx7 wildtype (control) and null pregnant females were treated with PolyIC as per the M_POLYIC_27_IN_B model. The targeting vector was inserted at Arg^505 codon, deleting from Cys^506 to Pro^532, in the carboxyl-terminal domain of the P2X7R gene product.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Horvth G , et al. (2019)
Communications - Not reported - - Horvth G , et al. (2019)
Developmental profile - Not reported - - Horvth G , et al. (2019)
Emotion - Not reported - - Horvth G , et al. (2019)
Immune response Cytokine levels: anti-inflammatory No adverse effect Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Immune response Cytokine levels: pro-inflammatory Restored Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Immune response Cytokine levels: pro-inflammatory No adverse effect Flow cytometric analysis Adult, E15 Horvth G , et al. (2019)
Learning & memory - Not reported - - Horvth G , et al. (2019)
Maternal behavior - Not reported - - Horvth G , et al. (2019)
Molecular profile - Not reported - - Horvth G , et al. (2019)
Motor phenotype - Not reported - - Horvth G , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical lamination Restored Immunofluorescence staining E14.5 Horvth G , et al. (2019)
Neurophysiology - Not reported - - Horvth G , et al. (2019)
Physiological parameters - Not reported - - Horvth G , et al. (2019)
Repetitive behavior - Not reported - - Horvth G , et al. (2019)
Seizure - Not reported - - Horvth G , et al. (2019)
Sensory - Not reported - - Horvth G , et al. (2019)
Social behavior - Not reported - - Horvth G , et al. (2019)

M_POLYIC_2_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E17 in 5 ml/kg.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Li Q , et al. (2009)
Communications - Not reported - - Li Q , et al. (2009)
Developmental profile - Not reported - - Li Q , et al. (2009)
Emotion - Not reported - - Li Q , et al. (2009)
Immune response - Not reported - - Li Q , et al. (2009)
Learning & memory - Not reported - - Li Q , et al. (2009)
Maternal behavior - Not reported - - Li Q , et al. (2009)
Molecular profile - Not reported - - Li Q , et al. (2009)
Motor phenotype - Not reported - - Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neurophysiology - Not reported - - Li Q , et al. (2009)
Physiological parameters - Not reported - - Li Q , et al. (2009)
Repetitive behavior - Not reported - - Li Q , et al. (2009)
Seizure - Not reported - - Li Q , et al. (2009)
Sensory Sensorimotor gating No change Prepulse inhibition 12 weeks Li Q , et al. (2009)
Social behavior - Not reported - - Li Q , et al. (2009)
Circadian sleep/wake cycle - Not reported - - Li Q , et al. (2010)
Communications - Not reported - - Li Q , et al. (2010)
Developmental profile - Not reported - - Li Q , et al. (2010)
Emotion - Not reported - - Li Q , et al. (2010)
Immune response - Not reported - - Li Q , et al. (2010)
Learning & memory - Not reported - - Li Q , et al. (2010)
Maternal behavior - Not reported - - Li Q , et al. (2010)
Molecular profile - Not reported - - Li Q , et al. (2010)
Motor phenotype - Not reported - - Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dti: fractional anisotropy or relative anisotropy in brain regions Abnormal Diffusion tensor imaging (dti) 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dti: fractional anisotropy or relative anisotropy in brain regions Abnormal Diffusion tensor imaging (dti) 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Myelination No change Immunohistochemistry Unreported Li Q , et al. (2010)
Neurophysiology - Not reported - - Li Q , et al. (2010)
Physiological parameters - Not reported - - Li Q , et al. (2010)
Repetitive behavior - Not reported - - Li Q , et al. (2010)
Seizure - Not reported - - Li Q , et al. (2010)
Sensory - Not reported - - Li Q , et al. (2010)
Social behavior - Not reported - - Li Q , et al. (2010)

M_POLYIC_2_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E17 in 5 ml/kg.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Li Q , et al. (2009)
Communications - Not reported - - Li Q , et al. (2009)
Developmental profile - Not reported - - Li Q , et al. (2009)
Emotion - Not reported - - Li Q , et al. (2009)
Immune response - Not reported - - Li Q , et al. (2009)
Learning & memory - Not reported - - Li Q , et al. (2009)
Maternal behavior - Not reported - - Li Q , et al. (2009)
Molecular profile - Not reported - - Li Q , et al. (2009)
Motor phenotype - Not reported - - Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology Abnormal Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain morphology No change Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size No change Magnetic resonance imaging (mri) 12 weeks Li Q , et al. (2009)
Neurophysiology - Not reported - - Li Q , et al. (2009)
Physiological parameters - Not reported - - Li Q , et al. (2009)
Repetitive behavior - Not reported - - Li Q , et al. (2009)
Seizure - Not reported - - Li Q , et al. (2009)
Sensory Sensorimotor gating No change Prepulse inhibition 12 weeks Li Q , et al. (2009)
Social behavior - Not reported - - Li Q , et al. (2009)
Circadian sleep/wake cycle - Not reported - - Li Q , et al. (2010)
Communications - Not reported - - Li Q , et al. (2010)
Developmental profile - Not reported - - Li Q , et al. (2010)
Emotion - Not reported - - Li Q , et al. (2010)
Immune response - Not reported - - Li Q , et al. (2010)
Learning & memory - Not reported - - Li Q , et al. (2010)
Maternal behavior - Not reported - - Li Q , et al. (2010)
Molecular profile - Not reported - - Li Q , et al. (2010)
Motor phenotype - Not reported - - Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dti: fractional anisotropy or relative anisotropy in brain regions Abnormal Diffusion tensor imaging (dti) 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dti: fractional anisotropy or relative anisotropy in brain regions Abnormal Diffusion tensor imaging (dti) 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Myelination No change Immunohistochemistry Unreported Li Q , et al. (2010)
Neurophysiology - Not reported - - Li Q , et al. (2010)
Physiological parameters - Not reported - - Li Q , et al. (2010)
Repetitive behavior - Not reported - - Li Q , et al. (2010)
Seizure - Not reported - - Li Q , et al. (2010)
Sensory - Not reported - - Li Q , et al. (2010)
Social behavior - Not reported - - Li Q , et al. (2010)

M_POLYIC_30_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6J*129/SvEv*CD1

Construct Definition:

E12.5 pregnant female mice, verified to be positive for segmented filamentous bacteria, were injected with a single dose of poly(I:C) (20mg/kg i.p.) or saline as a vehicle control.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Sensory Sensorimotor gating: tactile cue Increased Prepulse inhibition 6-8 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Increased Response to air puff 6-8 weeks Orefice LL , et al. (2019)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test 6-8 weeks Orefice LL , et al. (2019)

M_POLYIC_30_IN_B_ISOGUVACINE

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

E12.5 pregnant female mice, verified to be positive for segmented filamentous bacteria, were injected with a single dose of poly(I:C) (20mg/kg i.p.) or saline as a vehicle control. Isoguvacine, 2 mg/kg, i.p., was administered beginning at a young age (P1-P42) to test if it ameliorated tactile hypersensitivity in ASD models with fewer adverse effects than brain-penetrating benzodiazepines such as midazolam, including sedation and cognitive impairment, which are attributed to a CNS site of drug action.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Sensory Sensorimotor gating: tactile cue Restored Prepulse inhibition 6 weeks Orefice LL , et al. (2019)
Sensory Sensorimotor gating: tactile cue Restored Response to air puff 6 weeks Orefice LL , et al. (2019)
Sensory Startle response: acoustic stimulus No adverse effect Acoustic startle reflex test 6 weeks Orefice LL , et al. (2019)

M_POLYIC_31_IN_B

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant C57BL6/J female mice were intraperitoneally injected with 20 mg/kg poly(I:C) in potassium salts on E9.5, which corresponds to the beginning of microglial migration from the yolk sac into the brain in mice.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - ()
Communications Ultrasonic vocalization: Interaction induced: opposite sex stimulus No change Monitoring ultrasonic vocalizations 2.3 months ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response - Not Reported - - ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile Gene expression Abnormal RNA sequencing E17, P7, 2.9 weeks, 2 months ()
Molecular profile Gene expression Increased In situ hybridization (ISH) E17 ()
Molecular profile Gene expression Increased Quantitative PCR (qRT-PCR) E17 ()
Molecular profile Protein expression: In situ protein expression Increased ELISA 2 months ()
Motor phenotype General locomotor activity: Ambulatory activity No change Three-chamber social approach test 2.2-2.3 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture Increased Confocal microscopy 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology Abnormal Immunofluorescence staining 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial number Increased Immunohistochemistry 1.4 months, 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Miniature post synaptic current amplitude No change Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Miniature post synaptic current frequency Increased Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation and specification in the brain Decreased Immunohistochemistry 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event amplitude Decreased Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event amplitude No change Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event frequency No change Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event frequency No change Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Immunohistochemistry 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Increased Confocal microscopy 2 months ()
Neurophysiology Decay kinetics of miniature post synaptic currents Decreased Whole-cell patch clamp 2 months ()
Neurophysiology Intrinsic membrane properties Increased Whole-cell patch clamp 2 months ()
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1.93 - 2.1 months ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Decreased Three-chamber social approach test 2.2-2.3 months ()

M_POLYIC_31_IN_B_PLX5622

Model Source:

Jackson Laboratories

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Offsprings exposed to PolyI:C in utero were fed chow containing a CSF1R inhibitor PLX5622, from P21–42, followed by control chow from P42–68. Control mice were fed control chow from P21 to P68.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not Reported - - ()
Communications Ultrasonic vocalization: Interaction induced: opposite sex stimulus No adverse effect Monitoring ultrasonic vocalizations 2.3 months ()
Developmental profile - Not Reported - - ()
Emotion - Not Reported - - ()
Homeostasis - Not Reported - - ()
Immune response - Not Reported - - ()
Learning & memory - Not Reported - - ()
Maternal behavior - Not Reported - - ()
Molecular profile Gene expression Ameliorated RNA sequencing 2 months ()
Molecular profile Protein expression: In situ protein expression Restored ELISA 2 months ()
Motor phenotype General locomotor activity: Ambulatory activity No adverse effect Three-chamber social approach test 2.2-2.3 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture Restored Confocal microscopy 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology Restored Confocal microscopy 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial number Restored Immunohistochemistry 1.4 months, 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Miniature post synaptic current amplitude No adverse effect Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Miniature post synaptic current frequency Refractory Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal differentiation and specification in the brain Ameliorated Immunohistochemistry 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event amplitude No adverse effect Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event amplitude Refractory Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event frequency No adverse effect Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Spontaneous post synaptic event frequency No adverse effect Whole-cell patch clamp 2 months ()
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density Restored Confocal microscopy 2 months ()
Neurophysiology Decay kinetics of miniature post synaptic currents Restored Whole-cell patch clamp 2 months ()
Neurophysiology Intrinsic membrane properties No adverse effect Whole-cell patch clamp 2 months ()
Repetitive behavior Self grooming: perseveration Ameliorated Grooming behavior assessments 1.93 - 2.1 months ()
Seizure - Not Reported - - ()
Sensory - Not Reported - - ()
Social behavior Social approach Restored Three-chamber social approach test 2.2-2.3 months ()

M_POLYIC_3_IN_B

Model Source:

Simonson Laboratories

Model Type:

Induced

Strain of Origin:

BALB/c

Construct Definition:

Administration of PolyI:C on E9.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Shi L , et al. (2003)
Communications - Not reported - - Shi L , et al. (2003)
Developmental profile - Not reported - - Shi L , et al. (2003)
Emotion - Not reported - - Shi L , et al. (2003)
Immune response - Not reported - - Shi L , et al. (2003)
Learning & memory - Not reported - - Shi L , et al. (2003)
Maternal behavior - Not reported - - Shi L , et al. (2003)
Molecular profile - Not reported - - Shi L , et al. (2003)
Motor phenotype - Not reported - - Shi L , et al. (2003)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Shi L , et al. (2003)
Neurophysiology - Not reported - - Shi L , et al. (2003)
Physiological parameters - Not reported - - Shi L , et al. (2003)
Repetitive behavior - Not reported - - Shi L , et al. (2003)
Seizure - Not reported - - Shi L , et al. (2003)
Sensory Sensorimotor gating Decreased Prepulse inhibition 4-8 weeks Shi L , et al. (2003)
Social behavior - Not reported - - Shi L , et al. (2003)

M_POLYIC_4_IN_B

Model Source:

Univ. of Hong Kong, LAU

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E9 in 5 ml/kg.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Li Q , et al. (2010)
Communications - Not reported - - Li Q , et al. (2010)
Developmental profile - Not reported - - Li Q , et al. (2010)
Emotion - Not reported - - Li Q , et al. (2010)
Immune response - Not reported - - Li Q , et al. (2010)
Learning & memory - Not reported - - Li Q , et al. (2010)
Maternal behavior - Not reported - - Li Q , et al. (2010)
Molecular profile - Not reported - - Li Q , et al. (2010)
Motor phenotype - Not reported - - Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dti: fractional anisotropy or relative anisotropy in brain regions Abnormal Diffusion tensor imaging (dti) 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dti: fractional anisotropy or relative anisotropy in brain regions Abnormal Diffusion tensor imaging (dti) 12 weeks Li Q , et al. (2010)
Neuroanatomy / Ultrastructure / Cytoarchitecture Myelination Decreased Immunohistochemistry Unreported Li Q , et al. (2010)
Neurophysiology - Not reported - - Li Q , et al. (2010)
Physiological parameters - Not reported - - Li Q , et al. (2010)
Repetitive behavior - Not reported - - Li Q , et al. (2010)
Seizure - Not reported - - Li Q , et al. (2010)
Sensory - Not reported - - Li Q , et al. (2010)
Social behavior - Not reported - - Li Q , et al. (2010)

M_POLYIC_5_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E10.5, E12.5, and E14.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Malkova NV , et al. (2012)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations 8-9 weeks Malkova NV , et al. (2012)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations 8-9 weeks Malkova NV , et al. (2012)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations 10 days Malkova NV , et al. (2012)
Developmental profile Size/growth No change General observations Unreported Malkova NV , et al. (2012)
Emotion - Not reported - - Malkova NV , et al. (2012)
Immune response - Not reported - - Malkova NV , et al. (2012)
Learning & memory - Not reported - - Malkova NV , et al. (2012)
Maternal behavior Nest relocation No change General observations Unreported Malkova NV , et al. (2012)
Maternal behavior Pup retrieval No change Pup retrieval assay Unreported Malkova NV , et al. (2012)
Molecular profile - Not reported - - Malkova NV , et al. (2012)
Motor phenotype - Not reported - - Malkova NV , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Malkova NV , et al. (2012)
Neurophysiology - Not reported - - Malkova NV , et al. (2012)
Physiological parameters - Not reported - - Malkova NV , et al. (2012)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 13 weeks Malkova NV , et al. (2012)
Repetitive behavior Stereotypy Increased Marble-burying test 12 weeks Malkova NV , et al. (2012)
Seizure - Not reported - - Malkova NV , et al. (2012)
Sensory Ear twitch reflex or preyer's reflex No change Grasping reflex test Unreported Malkova NV , et al. (2012)
Sensory Ear twitch reflex or preyer's reflex No change Righting reflex test Unreported Malkova NV , et al. (2012)
Sensory Ear twitch reflex or preyer's reflex No change Negative geotaxis test Unreported Malkova NV , et al. (2012)
Sensory Olfaction No change Olfactory discrimination test 13-14 weeks Malkova NV , et al. (2012)
Social behavior Mating behavior Decreased Scent marking test 11 weeks Malkova NV , et al. (2012)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Malkova NV , et al. (2012)

M_POLYIC_6_IN_B

Model Source:

Jackson Laboratory; Harlan (Bicester, UK) [PMID#29462110]

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Increased Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Decreased Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Garbett KA , et al. (2012)
Communications - Not reported - - Garbett KA , et al. (2012)
Developmental profile Tissue weight Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not reported - - Garbett KA , et al. (2012)
Immune response - Not reported - - Garbett KA , et al. (2012)
Learning & memory - Not reported - - Garbett KA , et al. (2012)
Maternal behavior - Not reported - - Garbett KA , et al. (2012)
Molecular profile Gene expression Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 3.5, 12 months Garbett KA , et al. (2012)
Motor phenotype - Not reported - - Garbett KA , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Garbett KA , et al. (2012)
Neurophysiology - Not reported - - Garbett KA , et al. (2012)
Physiological parameters - Not reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not reported - - Garbett KA , et al. (2012)
Seizure - Not reported - - Garbett KA , et al. (2012)
Sensory - Not reported - - Garbett KA , et al. (2012)
Social behavior - Not reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P10 Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Giulivi C , et al. (2013)
Communications - Not reported - - Giulivi C , et al. (2013)
Developmental profile - Not reported - - Giulivi C , et al. (2013)
Emotion - Not reported - - Giulivi C , et al. (2013)
Immune response - Not reported - - Giulivi C , et al. (2013)
Learning & memory - Not reported - - Giulivi C , et al. (2013)
Maternal behavior - Not reported - - Giulivi C , et al. (2013)
Molecular profile Protein modification process Decreased Mitochondrial oxygen consumption studies 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not reported - - Giulivi C , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Giulivi C , et al. (2013)
Neurophysiology - Not reported - - Giulivi C , et al. (2013)
Physiological parameters - Not reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not reported - - Giulivi C , et al. (2013)
Seizure - Not reported - - Giulivi C , et al. (2013)
Sensory - Not reported - - Giulivi C , et al. (2013)
Social behavior - Not reported - - Giulivi C , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response No change Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Depression No change Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing No change General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability No change Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 12 weeks Morais LH , et al. (2018)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory No change Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Motor phenotype Climbing No change Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Climbing Decreased Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Gait No change Gait P33-P34 Haida O , et al. (2019)
Motor phenotype General locomotor activity No change Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype General locomotor activity Decreased Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype Motor coordination and balance No change Balance beam test P33 Haida O , et al. (2019)
Motor phenotype Negative geotaxis No change Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Negative geotaxis Decreased Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Righting response No change Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1 month Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior No change Novel cage test 1 month Haida O , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)

M_POLYIC_6_IN_B

Model Source:

Jackson Laboratory; Harlan (Bicester, UK) [PMID#29462110]

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Increased Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Decreased Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Garbett KA , et al. (2012)
Communications - Not reported - - Garbett KA , et al. (2012)
Developmental profile Tissue weight Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not reported - - Garbett KA , et al. (2012)
Immune response - Not reported - - Garbett KA , et al. (2012)
Learning & memory - Not reported - - Garbett KA , et al. (2012)
Maternal behavior - Not reported - - Garbett KA , et al. (2012)
Molecular profile Gene expression Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 3.5, 12 months Garbett KA , et al. (2012)
Motor phenotype - Not reported - - Garbett KA , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Garbett KA , et al. (2012)
Neurophysiology - Not reported - - Garbett KA , et al. (2012)
Physiological parameters - Not reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not reported - - Garbett KA , et al. (2012)
Seizure - Not reported - - Garbett KA , et al. (2012)
Sensory - Not reported - - Garbett KA , et al. (2012)
Social behavior - Not reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P10 Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Giulivi C , et al. (2013)
Communications - Not reported - - Giulivi C , et al. (2013)
Developmental profile - Not reported - - Giulivi C , et al. (2013)
Emotion - Not reported - - Giulivi C , et al. (2013)
Immune response - Not reported - - Giulivi C , et al. (2013)
Learning & memory - Not reported - - Giulivi C , et al. (2013)
Maternal behavior - Not reported - - Giulivi C , et al. (2013)
Molecular profile Protein modification process Decreased Mitochondrial oxygen consumption studies 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not reported - - Giulivi C , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Giulivi C , et al. (2013)
Neurophysiology - Not reported - - Giulivi C , et al. (2013)
Physiological parameters - Not reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not reported - - Giulivi C , et al. (2013)
Seizure - Not reported - - Giulivi C , et al. (2013)
Sensory - Not reported - - Giulivi C , et al. (2013)
Social behavior - Not reported - - Giulivi C , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response No change Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Depression No change Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing No change General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability No change Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 12 weeks Morais LH , et al. (2018)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory No change Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Motor phenotype Climbing No change Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Climbing Decreased Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Gait No change Gait P33-P34 Haida O , et al. (2019)
Motor phenotype General locomotor activity No change Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype General locomotor activity Decreased Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype Motor coordination and balance No change Balance beam test P33 Haida O , et al. (2019)
Motor phenotype Negative geotaxis No change Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Negative geotaxis Decreased Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Righting response No change Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1 month Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior No change Novel cage test 1 month Haida O , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)

M_POLYIC_6_IN_B

Model Source:

Jackson Laboratory; Harlan (Bicester, UK) [PMID#29462110]

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Increased Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Decreased Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Garbett KA , et al. (2012)
Communications - Not reported - - Garbett KA , et al. (2012)
Developmental profile Tissue weight Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not reported - - Garbett KA , et al. (2012)
Immune response - Not reported - - Garbett KA , et al. (2012)
Learning & memory - Not reported - - Garbett KA , et al. (2012)
Maternal behavior - Not reported - - Garbett KA , et al. (2012)
Molecular profile Gene expression Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 3.5, 12 months Garbett KA , et al. (2012)
Motor phenotype - Not reported - - Garbett KA , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Garbett KA , et al. (2012)
Neurophysiology - Not reported - - Garbett KA , et al. (2012)
Physiological parameters - Not reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not reported - - Garbett KA , et al. (2012)
Seizure - Not reported - - Garbett KA , et al. (2012)
Sensory - Not reported - - Garbett KA , et al. (2012)
Social behavior - Not reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P10 Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Giulivi C , et al. (2013)
Communications - Not reported - - Giulivi C , et al. (2013)
Developmental profile - Not reported - - Giulivi C , et al. (2013)
Emotion - Not reported - - Giulivi C , et al. (2013)
Immune response - Not reported - - Giulivi C , et al. (2013)
Learning & memory - Not reported - - Giulivi C , et al. (2013)
Maternal behavior - Not reported - - Giulivi C , et al. (2013)
Molecular profile Protein modification process Decreased Mitochondrial oxygen consumption studies 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not reported - - Giulivi C , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Giulivi C , et al. (2013)
Neurophysiology - Not reported - - Giulivi C , et al. (2013)
Physiological parameters - Not reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not reported - - Giulivi C , et al. (2013)
Seizure - Not reported - - Giulivi C , et al. (2013)
Sensory - Not reported - - Giulivi C , et al. (2013)
Social behavior - Not reported - - Giulivi C , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response No change Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Depression No change Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing No change General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability No change Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 12 weeks Morais LH , et al. (2018)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory No change Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Motor phenotype Climbing No change Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Climbing Decreased Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Gait No change Gait P33-P34 Haida O , et al. (2019)
Motor phenotype General locomotor activity No change Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype General locomotor activity Decreased Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype Motor coordination and balance No change Balance beam test P33 Haida O , et al. (2019)
Motor phenotype Negative geotaxis No change Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Negative geotaxis Decreased Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Righting response No change Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1 month Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior No change Novel cage test 1 month Haida O , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)

M_POLYIC_6_IN_B

Model Source:

Jackson Laboratory; Harlan (Bicester, UK) [PMID#29462110]

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Increased Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Decreased Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Garbett KA , et al. (2012)
Communications - Not reported - - Garbett KA , et al. (2012)
Developmental profile Tissue weight Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not reported - - Garbett KA , et al. (2012)
Immune response - Not reported - - Garbett KA , et al. (2012)
Learning & memory - Not reported - - Garbett KA , et al. (2012)
Maternal behavior - Not reported - - Garbett KA , et al. (2012)
Molecular profile Gene expression Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 3.5, 12 months Garbett KA , et al. (2012)
Motor phenotype - Not reported - - Garbett KA , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Garbett KA , et al. (2012)
Neurophysiology - Not reported - - Garbett KA , et al. (2012)
Physiological parameters - Not reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not reported - - Garbett KA , et al. (2012)
Seizure - Not reported - - Garbett KA , et al. (2012)
Sensory - Not reported - - Garbett KA , et al. (2012)
Social behavior - Not reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P10 Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Giulivi C , et al. (2013)
Communications - Not reported - - Giulivi C , et al. (2013)
Developmental profile - Not reported - - Giulivi C , et al. (2013)
Emotion - Not reported - - Giulivi C , et al. (2013)
Immune response - Not reported - - Giulivi C , et al. (2013)
Learning & memory - Not reported - - Giulivi C , et al. (2013)
Maternal behavior - Not reported - - Giulivi C , et al. (2013)
Molecular profile Protein modification process Decreased Mitochondrial oxygen consumption studies 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not reported - - Giulivi C , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Giulivi C , et al. (2013)
Neurophysiology - Not reported - - Giulivi C , et al. (2013)
Physiological parameters - Not reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not reported - - Giulivi C , et al. (2013)
Seizure - Not reported - - Giulivi C , et al. (2013)
Sensory - Not reported - - Giulivi C , et al. (2013)
Social behavior - Not reported - - Giulivi C , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response No change Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Depression No change Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing No change General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability No change Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 12 weeks Morais LH , et al. (2018)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory No change Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Motor phenotype Climbing No change Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Climbing Decreased Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Gait No change Gait P33-P34 Haida O , et al. (2019)
Motor phenotype General locomotor activity No change Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype General locomotor activity Decreased Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype Motor coordination and balance No change Balance beam test P33 Haida O , et al. (2019)
Motor phenotype Negative geotaxis No change Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Negative geotaxis Decreased Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Righting response No change Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1 month Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior No change Novel cage test 1 month Haida O , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)

M_POLYIC_6_IN_B

Model Source:

Jackson Laboratory; Harlan (Bicester, UK) [PMID#29462110]

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Increased Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Decreased Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Garbett KA , et al. (2012)
Communications - Not reported - - Garbett KA , et al. (2012)
Developmental profile Tissue weight Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not reported - - Garbett KA , et al. (2012)
Immune response - Not reported - - Garbett KA , et al. (2012)
Learning & memory - Not reported - - Garbett KA , et al. (2012)
Maternal behavior - Not reported - - Garbett KA , et al. (2012)
Molecular profile Gene expression Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 3.5, 12 months Garbett KA , et al. (2012)
Motor phenotype - Not reported - - Garbett KA , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Garbett KA , et al. (2012)
Neurophysiology - Not reported - - Garbett KA , et al. (2012)
Physiological parameters - Not reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not reported - - Garbett KA , et al. (2012)
Seizure - Not reported - - Garbett KA , et al. (2012)
Sensory - Not reported - - Garbett KA , et al. (2012)
Social behavior - Not reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P10 Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Giulivi C , et al. (2013)
Communications - Not reported - - Giulivi C , et al. (2013)
Developmental profile - Not reported - - Giulivi C , et al. (2013)
Emotion - Not reported - - Giulivi C , et al. (2013)
Immune response - Not reported - - Giulivi C , et al. (2013)
Learning & memory - Not reported - - Giulivi C , et al. (2013)
Maternal behavior - Not reported - - Giulivi C , et al. (2013)
Molecular profile Protein modification process Decreased Mitochondrial oxygen consumption studies 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not reported - - Giulivi C , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Giulivi C , et al. (2013)
Neurophysiology - Not reported - - Giulivi C , et al. (2013)
Physiological parameters - Not reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not reported - - Giulivi C , et al. (2013)
Seizure - Not reported - - Giulivi C , et al. (2013)
Sensory - Not reported - - Giulivi C , et al. (2013)
Social behavior - Not reported - - Giulivi C , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response No change Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Depression No change Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing No change General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability No change Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 12 weeks Morais LH , et al. (2018)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory No change Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Motor phenotype Climbing No change Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Climbing Decreased Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Gait No change Gait P33-P34 Haida O , et al. (2019)
Motor phenotype General locomotor activity No change Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype General locomotor activity Decreased Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype Motor coordination and balance No change Balance beam test P33 Haida O , et al. (2019)
Motor phenotype Negative geotaxis No change Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Negative geotaxis Decreased Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Righting response No change Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1 month Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior No change Novel cage test 1 month Haida O , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)

M_POLYIC_6_IN_B

Model Source:

Jackson Laboratory; Harlan (Bicester, UK) [PMID#29462110]

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Increased Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Decreased Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Abnormal Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Decreased Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Decreased Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Garbett KA , et al. (2012)
Communications - Not reported - - Garbett KA , et al. (2012)
Developmental profile Tissue weight Decreased Measurement of placental weight Unreported Garbett KA , et al. (2012)
Emotion - Not reported - - Garbett KA , et al. (2012)
Immune response - Not reported - - Garbett KA , et al. (2012)
Learning & memory - Not reported - - Garbett KA , et al. (2012)
Maternal behavior - Not reported - - Garbett KA , et al. (2012)
Molecular profile Gene expression Abnormal Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression Increased Gene expression microarray E12.5 Garbett KA , et al. (2012)
Molecular profile Gene expression No change Quantitative pcr (qrt-pcr) 3.5, 12 months Garbett KA , et al. (2012)
Motor phenotype - Not reported - - Garbett KA , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Garbett KA , et al. (2012)
Neurophysiology - Not reported - - Garbett KA , et al. (2012)
Physiological parameters - Not reported - - Garbett KA , et al. (2012)
Repetitive behavior - Not reported - - Garbett KA , et al. (2012)
Seizure - Not reported - - Garbett KA , et al. (2012)
Sensory - Not reported - - Garbett KA , et al. (2012)
Social behavior - Not reported - - Garbett KA , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P10 Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization No change Monitoring ultrasonic vocalizations P8 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Giulivi C , et al. (2013)
Communications - Not reported - - Giulivi C , et al. (2013)
Developmental profile - Not reported - - Giulivi C , et al. (2013)
Emotion - Not reported - - Giulivi C , et al. (2013)
Immune response - Not reported - - Giulivi C , et al. (2013)
Learning & memory - Not reported - - Giulivi C , et al. (2013)
Maternal behavior - Not reported - - Giulivi C , et al. (2013)
Molecular profile Protein modification process Decreased Mitochondrial oxygen consumption studies 12 weeks Giulivi C , et al. (2013)
Motor phenotype - Not reported - - Giulivi C , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Giulivi C , et al. (2013)
Neurophysiology - Not reported - - Giulivi C , et al. (2013)
Physiological parameters - Not reported - - Giulivi C , et al. (2013)
Repetitive behavior - Not reported - - Giulivi C , et al. (2013)
Seizure - Not reported - - Giulivi C , et al. (2013)
Sensory - Not reported - - Giulivi C , et al. (2013)
Social behavior - Not reported - - Giulivi C , et al. (2013)
Circadian sleep/wake cycle - Not reported - - Morais LH , et al. (2018)
Communications Ultrasonic vocalization: isolation induced No change Monitoring ultrasonic vocalizations P9 Morais LH , et al. (2018)
Developmental profile - Not reported - - Morais LH , et al. (2018)
Emotion Acute stress response No change Elisa 14 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Open field test 10 weeks Morais LH , et al. (2018)
Emotion Anxiety No change Elevated plus maze test 11 weeks Morais LH , et al. (2018)
Emotion Depression No change Forced swim test 14 weeks Morais LH , et al. (2018)
Immune response - Not reported - - Morais LH , et al. (2018)
Learning & memory Object recognition memory No change Novel object recognition test 10 weeks Morais LH , et al. (2018)
Maternal behavior Maternal nurturing No change General observations P6 Morais LH , et al. (2018)
Molecular profile - Not reported - - Morais LH , et al. (2018)
Motor phenotype General locomotor activity: ambulatory activity No change Open field test 10 weeks Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: oxt No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: vasopressin No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Neurophysiology - Not reported - - Morais LH , et al. (2018)
Physiological parameters - Not reported - - Morais LH , et al. (2018)
Physiological parameters Digestive system function: gastrointestinal motility No change Intestinal transit time 13 weeks Morais LH , et al. (2018)
Physiological parameters Digestive system function: intestinal barrier: intestinal permeability No change Intestinal permeability test 13 weeks Morais LH , et al. (2018)
Physiological parameters Hormone levels No change Quantitative pcr (qrt-pcr) - Morais LH , et al. (2018)
Repetitive behavior Repetitive digging Increased Marble-burying test 8 weeks Morais LH , et al. (2018)
Seizure - Not reported - - Morais LH , et al. (2018)
Sensory - Not reported - - Morais LH , et al. (2018)
Social behavior Social approach Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social interaction Decreased Reciprocal social interaction test 4 weeks Morais LH , et al. (2018)
Social behavior Social memory Decreased Three-chamber social approach test 9 weeks Morais LH , et al. (2018)
Social behavior Social scent marking or recognition No change Homing test P10 Morais LH , et al. (2018)
Social behavior Social transmission of food preference Decreased Social transmission of food preference 12 weeks Morais LH , et al. (2018)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory Decreased Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Developmental profile Developmental trajectory No change Developmental milestone measurements P12-P16 Haida O , et al. (2019)
Motor phenotype Climbing No change Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Climbing Decreased Climbing assay 1 month Haida O , et al. (2019)
Motor phenotype Gait No change Gait P33-P34 Haida O , et al. (2019)
Motor phenotype General locomotor activity No change Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype General locomotor activity Decreased Ambulation recordings 1 month Haida O , et al. (2019)
Motor phenotype Motor coordination and balance No change Balance beam test P33 Haida O , et al. (2019)
Motor phenotype Negative geotaxis No change Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Negative geotaxis Decreased Negative geotaxis test 1 month Haida O , et al. (2019)
Motor phenotype Righting response No change Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Motor phenotype Righting response Decreased Righting reflex test P9, P11, P13 Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Glial morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neocortex morphology Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Decreased Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells No change Immunohistochemistry 6.4 weeks Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration Increased Grooming behavior assessments 1 month Haida O , et al. (2019)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior Decreased Novel cage test 1 month Haida O , et al. (2019)
Social behavior Rearing behavior No change Novel cage test 1 month Haida O , et al. (2019)
Social behavior Social approach No change Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)
Social behavior Social approach Decreased Three-chamber social approach test 5-6 weeks Haida O , et al. (2019)

M_POLYIC_6_IN_B_ANTIIL6

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Administration of PolyI:C on E12.5, co-administration of 100 microg of anti-IL-6, rat IgG1.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Restored Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Restored Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile Gene expression Ameliorated Gene expression microarray Adult Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Restored Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Restored Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Restored Three-chamber social approach test Adult Smith SE , et al. (2007)

M_POLYIC_6_IN_B_IL6_KO

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J (backcrossed 11 generations from B6.129S2-IL6tm1Kopf/J)

Construct Definition:

Administration of PolyI:C on E12.5 in IL6 knockout.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Restored Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Side effect Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile - Not reported - - Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Restored Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Restored Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Restored Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications - Not reported - - Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Restored Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype - Not reported - - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior - Not reported - - Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior - Not reported - - Choi GB , et al. (2016)

M_POLYIC_6_IN_B_IL6_KO

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J (backcrossed 11 generations from B6.129S2-IL6tm1Kopf/J)

Construct Definition:

Administration of PolyI:C on E12.5 in IL6 knockout.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Smith SE , et al. (2007)
Communications - Not reported - - Smith SE , et al. (2007)
Developmental profile - Not reported - - Smith SE , et al. (2007)
Emotion Anxiety Restored Open field test Adult Smith SE , et al. (2007)
Immune response - Not reported - - Smith SE , et al. (2007)
Learning & memory Cued or contextual fear conditioning: latent inhibition Side effect Fear conditioning test Adult Smith SE , et al. (2007)
Maternal behavior - Not reported - - Smith SE , et al. (2007)
Molecular profile - Not reported - - Smith SE , et al. (2007)
Motor phenotype General locomotor activity: ambulatory activity Restored Open field test Adult Smith SE , et al. (2007)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Smith SE , et al. (2007)
Neurophysiology - Not reported - - Smith SE , et al. (2007)
Physiological parameters - Not reported - - Smith SE , et al. (2007)
Repetitive behavior - Not reported - - Smith SE , et al. (2007)
Seizure - Not reported - - Smith SE , et al. (2007)
Sensory Sensorimotor gating Restored Prepulse inhibition Adult Smith SE , et al. (2007)
Social behavior Social approach Restored Three-chamber social approach test Adult Smith SE , et al. (2007)
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications - Not reported - - Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response Cytokine levels: pro-inflammatory Restored Elisa E14.5 Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype - Not reported - - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior - Not reported - - Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior - Not reported - - Choi GB , et al. (2016)

M_POLYIC_6_IN_B_IL6_KO_RIL17A

Model Source:

-

Model Type:

Induced

Strain of Origin:

-

Construct Definition:

Administration of PolyI:C on E12.5 in IL6 knockout mice, at E 14.5 uterine horns of pregnant mice were exposed by a caudal ventral midlineincision (<2 cm). Recombinant mouse IL-17a cytokine (R&D) at 0.6 L of 2 ng/L was injected into the third ventricle of each embryo by a pulled micropipette, after injection of all embryos the uterus was replaced in the abdomen. Note that behavioral and anatomical testing is conducted in the offspring but the sera tested are of the pregnant dams.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Choi GB , et al. (2016)
Communications Ultrasonic vocalization: isolation induced Increased Monitoring ultrasonic vocalizations - Choi GB , et al. (2016)
Developmental profile - Not reported - - Choi GB , et al. (2016)
Emotion - Not reported - - Choi GB , et al. (2016)
Immune response - Not reported - - Choi GB , et al. (2016)
Learning & memory - Not reported - - Choi GB , et al. (2016)
Maternal behavior - Not reported - - Choi GB , et al. (2016)
Molecular profile - Not reported - - Choi GB , et al. (2016)
Motor phenotype - Not reported - - Choi GB , et al. (2016)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Choi GB , et al. (2016)
Neurophysiology - Not reported - - Choi GB , et al. (2016)
Physiological parameters - Not reported - - Choi GB , et al. (2016)
Repetitive behavior - Not reported - - Choi GB , et al. (2016)
Seizure - Not reported - - Choi GB , et al. (2016)
Sensory - Not reported - - Choi GB , et al. (2016)
Social behavior - Not reported - - Choi GB , et al. (2016)

M_POLYIC_7_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2012)
Communications - Not reported - - Hsiao EY , et al. (2012)
Developmental profile - Not reported - - Hsiao EY , et al. (2012)
Emotion Anxiety Increased Open field test Unreported Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells No change Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Immunosuppression Increased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Innate immune response Abnormal Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Learning & memory - Not reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not reported - - Hsiao EY , et al. (2012)
Molecular profile - Not reported - - Hsiao EY , et al. (2012)
Motor phenotype - Not reported - - Hsiao EY , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not reported - - Hsiao EY , et al. (2012)
Physiological parameters - Not reported - - Hsiao EY , et al. (2012)
Repetitive behavior Repetitive digging Increased Marble-burying test Unreported Hsiao EY , et al. (2012)
Seizure - Not reported - - Hsiao EY , et al. (2012)
Sensory Sensorimotor gating Decreased Prepulse inhibition Unreported Hsiao EY , et al. (2012)
Social behavior Social interaction Decreased Three-chamber social approach test Unreported Hsiao EY , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2013)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations 6 weeks Hsiao EY , et al. (2013)
Developmental profile - Not reported - - Hsiao EY , et al. (2013)
Emotion Anxiety Increased Open field test 6 weeks Hsiao EY , et al. (2013)
Immune response Cytokine levels Decreased Elisa Unreported Hsiao EY , et al. (2013)
Immune response Cytokine levels Increased Elisa Unreported Hsiao EY , et al. (2013)
Immune response Cytokine levels Decreased Elisa Unreported Hsiao EY , et al. (2013)
Learning & memory - Not reported - - Hsiao EY , et al. (2013)
Maternal behavior - Not reported - - Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Decreased Quantitative pcr (qrt-pcr) Adult Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Increased Quantitative pcr (qrt-pcr) Adult Hsiao EY , et al. (2013)
Motor phenotype - Not reported - - Hsiao EY , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2013)
Neurophysiology - Not reported - - Hsiao EY , et al. (2013)
Physiological parameters - Not reported - - Hsiao EY , et al. (2013)
Physiological parameters Homeostasis Decreased Intestinal permeability test 3 weeks, adult Hsiao EY , et al. (2013)
Physiological parameters Intestinal microbiota composition Abnormal 16s rrna gene sequence analysis for identification of bacteria Unreported Hsiao EY , et al. (2013)
Repetitive behavior Repetitive digging Increased Marble-burying test 6 weeks Hsiao EY , et al. (2013)
Seizure - Not reported - - Hsiao EY , et al. (2013)
Sensory Sensorimotor gating Decreased Prepulse inhibition 6 weeks Hsiao EY , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)

M_POLYIC_7_IN_B

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2012)
Communications - Not reported - - Hsiao EY , et al. (2012)
Developmental profile - Not reported - - Hsiao EY , et al. (2012)
Emotion Anxiety Increased Open field test Unreported Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells Decreased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells No change Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Immunosuppression Increased Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Immune response Innate immune response Abnormal Flow cytometric analysis Unreported Hsiao EY , et al. (2012)
Learning & memory - Not reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not reported - - Hsiao EY , et al. (2012)
Molecular profile - Not reported - - Hsiao EY , et al. (2012)
Motor phenotype - Not reported - - Hsiao EY , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not reported - - Hsiao EY , et al. (2012)
Physiological parameters - Not reported - - Hsiao EY , et al. (2012)
Repetitive behavior Repetitive digging Increased Marble-burying test Unreported Hsiao EY , et al. (2012)
Seizure - Not reported - - Hsiao EY , et al. (2012)
Sensory Sensorimotor gating Decreased Prepulse inhibition Unreported Hsiao EY , et al. (2012)
Social behavior Social interaction Decreased Three-chamber social approach test Unreported Hsiao EY , et al. (2012)
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2013)
Communications Ultrasonic vocalization Decreased Monitoring ultrasonic vocalizations 6 weeks Hsiao EY , et al. (2013)
Developmental profile - Not reported - - Hsiao EY , et al. (2013)
Emotion Anxiety Increased Open field test 6 weeks Hsiao EY , et al. (2013)
Immune response Cytokine levels Decreased Elisa Unreported Hsiao EY , et al. (2013)
Immune response Cytokine levels Increased Elisa Unreported Hsiao EY , et al. (2013)
Immune response Cytokine levels Decreased Elisa Unreported Hsiao EY , et al. (2013)
Learning & memory - Not reported - - Hsiao EY , et al. (2013)
Maternal behavior - Not reported - - Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Decreased Quantitative pcr (qrt-pcr) Adult Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Increased Quantitative pcr (qrt-pcr) Adult Hsiao EY , et al. (2013)
Motor phenotype - Not reported - - Hsiao EY , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2013)
Neurophysiology - Not reported - - Hsiao EY , et al. (2013)
Physiological parameters - Not reported - - Hsiao EY , et al. (2013)
Physiological parameters Homeostasis Decreased Intestinal permeability test 3 weeks, adult Hsiao EY , et al. (2013)
Physiological parameters Intestinal microbiota composition Abnormal 16s rrna gene sequence analysis for identification of bacteria Unreported Hsiao EY , et al. (2013)
Repetitive behavior Repetitive digging Increased Marble-burying test 6 weeks Hsiao EY , et al. (2013)
Seizure - Not reported - - Hsiao EY , et al. (2013)
Sensory Sensorimotor gating Decreased Prepulse inhibition 6 weeks Hsiao EY , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)

M_POLYIC_7_IN_B_BFRAGILIS

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5 followed by oral gavage administration of B. fragilis NCTC 9343 every other day for 6 days at weaning (3 weeks of age).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2013)
Communications Ultrasonic vocalization Restored Monitoring ultrasonic vocalizations 6 weeks Hsiao EY , et al. (2013)
Developmental profile - Not reported - - Hsiao EY , et al. (2013)
Emotion Anxiety Restored Open field test 6 weeks Hsiao EY , et al. (2013)
Immune response Cytokine levels Restored Cytokine level detection 8 weeks Hsiao EY , et al. (2013)
Learning & memory - Not reported - - Hsiao EY , et al. (2013)
Maternal behavior - Not reported - - Hsiao EY , et al. (2013)
Molecular profile Metabolite level quantification Restored Gas chromatography-mass spectrometry (gc-ms) Adult Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Restored Quantitative pcr (qrt-pcr) 8 weeks Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Refractory Quantitative pcr (qrt-pcr) 6 weeks Hsiao EY , et al. (2013)
Molecular profile Regulation of gene expression Ameliorated Quantitative pcr (qrt-pcr) 8 weeks Hsiao EY , et al. (2013)
Motor phenotype General locomotor activity No adverse effect Open field test 6 weeks Hsiao EY , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2013)
Neurophysiology - Not reported - - Hsiao EY , et al. (2013)
Physiological parameters - Not reported - - Hsiao EY , et al. (2013)
Physiological parameters Homeostasis Restored Intestinal permeability test 8 weeks Hsiao EY , et al. (2013)
Physiological parameters Intestinal microbiota composition Ameliorated 16s rrna gene sequence analysis for identification of bacteria Unreported Hsiao EY , et al. (2013)
Repetitive behavior Repetitive digging Restored Marble-burying test 6 weeks Hsiao EY , et al. (2013)
Seizure - Not reported - - Hsiao EY , et al. (2013)
Sensory Sensorimotor gating Restored Prepulse inhibition 6 weeks Hsiao EY , et al. (2013)
Social behavior Social approach Refractory Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)
Social behavior Social interaction Refractory Three-chamber social approach test 6 weeks Hsiao EY , et al. (2013)

M_POLYIC_7_IN_B_BM

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5 followed by radiation and injection of bone marrow cells from polyI:C offspring.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2012)
Communications - Not reported - - Hsiao EY , et al. (2012)
Developmental profile - Not reported - - Hsiao EY , et al. (2012)
Emotion Anxiety Restored Open field test 17-19 weeks Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells Restored Flow cytometric analysis 19-20 weeks Hsiao EY , et al. (2012)
Immune response Cytokine levels Restored Flow cytometric analysis 19-20 weeks Hsiao EY , et al. (2012)
Immune response Immunosuppression Restored Flow cytometric analysis 19-20 weeks Hsiao EY , et al. (2012)
Learning & memory - Not reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not reported - - Hsiao EY , et al. (2012)
Molecular profile - Not reported - - Hsiao EY , et al. (2012)
Motor phenotype General locomotor activity Side effect Open field test 17-19 weeks Hsiao EY , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not reported - - Hsiao EY , et al. (2012)
Physiological parameters - Not reported - - Hsiao EY , et al. (2012)
Repetitive behavior Repetitive digging Restored Marble-burying test 17-19 weeks Hsiao EY , et al. (2012)
Seizure - Not reported - - Hsiao EY , et al. (2012)
Sensory - Not reported - - Hsiao EY , et al. (2012)
Social behavior Social interaction Refractory Three-chamber social approach test 17-19 weeks Hsiao EY , et al. (2012)

M_POLYIC_7_IN_B_BM_S

Model Source:

Charles River

Model Type:

Induced

Strain of Origin:

C57BL/6N

Construct Definition:

Administration of PolyI:C on E12.5 followed by radiation and injection of bone marrow cells from saline offspring.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Hsiao EY , et al. (2012)
Communications - Not reported - - Hsiao EY , et al. (2012)
Developmental profile - Not reported - - Hsiao EY , et al. (2012)
Emotion Anxiety Restored Open field test 4 months Hsiao EY , et al. (2012)
Immune response Adaptive immune response: t cells Restored Flow cytometric analysis 4.5 months Hsiao EY , et al. (2012)
Immune response Cytokine levels Restored Flow cytometric analysis 4.5 months Hsiao EY , et al. (2012)
Immune response Immunosuppression Restored Flow cytometric analysis 4.5 months Hsiao EY , et al. (2012)
Learning & memory - Not reported - - Hsiao EY , et al. (2012)
Maternal behavior - Not reported - - Hsiao EY , et al. (2012)
Molecular profile - Not reported - - Hsiao EY , et al. (2012)
Motor phenotype General locomotor activity Side effect Open field test 4 months Hsiao EY , et al. (2012)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Hsiao EY , et al. (2012)
Neurophysiology - Not reported - - Hsiao EY , et al. (2012)
Physiological parameters - Not reported - - Hsiao EY , et al. (2012)
Repetitive behavior Repetitive digging Restored Marble-burying test 4 months Hsiao EY , et al. (2012)
Seizure - Not reported - - Hsiao EY , et al. (2012)
Sensory - Not reported - - Hsiao EY , et al. (2012)
Social behavior Social interaction Refractory Three-chamber social approach test 4 months Hsiao EY , et al. (2012)

M_POLYIC_8_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

BTBR

Construct Definition:

Administration of PolyI:C on E12.5.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Schwartzer JJ , et al. (2013)
Communications Ultrasonic vocalization Increased Monitoring ultrasonic vocalizations P8, P10 Schwartzer JJ , et al. (2013)
Developmental profile - Not reported - - Schwartzer JJ , et al. (2013)
Emotion - Not reported - - Schwartzer JJ , et al. (2013)
Immune response Cytokine levels Abnormal Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Immune response Cytokine levels No change Stimulation of immune cells Unreported Schwartzer JJ , et al. (2013)
Learning & memory - Not reported - - Schwartzer JJ , et al. (2013)
Maternal behavior - Not reported - - Schwartzer JJ , et al. (2013)
Molecular profile - Not reported - - Schwartzer JJ , et al. (2013)
Motor phenotype - Not reported - - Schwartzer JJ , et al. (2013)
Neuroanatomy / ultrastructure / cytoarchitecture - Not reported - - Schwartzer JJ , et al. (2013)
Neurophysiology - Not reported - - Schwartzer JJ , et al. (2013)
Physiological parameters - Not reported - - Schwartzer JJ , et al. (2013)
Repetitive behavior Stereotypy Increased Marble-burying test Unreported Schwartzer JJ , et al. (2013)
Seizure - Not reported - - Schwartzer JJ , et al. (2013)
Sensory - Not reported - - Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context Increased Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Self grooming: social context No change Grooming behavior assessments Unreported Schwartzer JJ , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)
Social behavior Social interaction Decreased Three-chamber social approach test 10 weeks Schwartzer JJ , et al. (2013)

M_POLYIC_9_IN_B

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

Pregnant dams received a single i.p. administration of PolyI:C on E12.5 (cohort 1 as in PMID #23516405 wherein primiparous dams were mated at 12-14 weeks with 4 month old sires).

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle Locomotor activity in diurnal cycle: dark phase No change Open field test 8 weeks Naviaux RK , et al. (2013)
Communications - Not reported - - Naviaux RK , et al. (2013)
Developmental profile Mortality/lethality No change General observations P0 Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body length measurement 14 weeks Naviaux RK , et al. (2013)
Developmental profile Size/growth No change Body weight measurement 14 weeks Naviaux RK , et al. (2013)
Emotion - Not reported - - Naviaux RK , et al. (2013)
Immune response Adaptive immune response: b cells antibody production No change Antibody levels 15 weeks Naviaux RK , et al. (2013)
Immune response Cns inflammation Increased Western blot 16 weeks Naviaux RK , et al. (2013)
Learning & memory - Not reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not reported - - Naviaux RK , et al. (2013)
Molecular profile Protein expression level evidence No change Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile Protein phosphorylation Decreased Western blot 16 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance Decreased Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: acetylcholine No change Western blot 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size Abnormal Transmission electron microscopy (tem) 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Abnormal Transmission electron microscopy (tem) 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic neuroreceptors Decreased Western blot 16 weeks Naviaux RK , et al. (2013)
Neurophysiology - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Decreased Body temperature measurement 16 weeks - 8 months Naviaux RK , et al. (2013)
Physiological parameters Hormone levels No change Corticosterone measurements 12 weeks Naviaux RK , et al. (2013)
Physiological parameters Mitochondrial function Increased Mitochondrial respiratory chain enzyme analysis - Naviaux RK , et al. (2013)
Physiological parameters Respiratory function Decreased Respiration rate and pattern analysis - Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Food intake measurements Unreported Naviaux RK , et al. (2013)
Physiological parameters Satiety response No change Water intake measurements Unreported Naviaux RK , et al. (2013)
Repetitive behavior - Not reported - - Naviaux RK , et al. (2013)
Seizure - Not reported - - Naviaux RK , et al. (2013)
Sensory - Not reported - - Naviaux RK , et al. (2013)
Social behavior Social approach Decreased Three-chamber social approach test 10 weeks Naviaux RK , et al. (2013)

M_POLYIC_9_IN_B_SURAMIN

Model Source:

Jackson Laboratory

Model Type:

Induced

Strain of Origin:

C57BL/6J

Construct Definition:

M_POLYIC_9_IN_B offsprings received weekly intraperitoneal administration of 10 or 20 mg/kg of suramin dissolved in saline starting at 6 weeks of age.

Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle - Not reported - - Naviaux RK , et al. (2013)
Communications - Not reported - - Naviaux RK , et al. (2013)
Developmental profile Size/growth No adverse effect Body length measurement 14 weeks Naviaux RK , et al. (2013)
Developmental profile Size/growth No adverse effect Body weight measurement 14 weeks Naviaux RK , et al. (2013)
Emotion - Not reported - - Naviaux RK , et al. (2013)
Immune response Adaptive immune response: b cells antibody production Side effect Antibody levels 15 weeks Naviaux RK , et al. (2013)
Immune response Cns inflammation Restored Western blot 16 weeks Naviaux RK , et al. (2013)
Learning & memory - Not reported - - Naviaux RK , et al. (2013)
Maternal behavior - Not reported - - Naviaux RK , et al. (2013)
Molecular profile Protein expression level evidence No adverse effect Western blot 16 weeks Naviaux RK , et al. (2013)
Molecular profile Protein phosphorylation Restored Western blot 16 weeks Naviaux RK , et al. (2013)
Motor phenotype General locomotor activity No adverse effect Open field test 14 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance No adverse effect Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Motor phenotype Motor coordination and balance Restored Accelerating rotarod test 11 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuronal number: purkinje cells Restored Immunohistochemistry 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Neuroreceptor levels: acetylcholine Side effect Western blot 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Post-synaptic density size Restored Transmission electron microscopy (tem) 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic morphology Restored Transmission electron microscopy (tem) 16 weeks Naviaux RK , et al. (2013)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synaptic neuroreceptors Restored Western blot 16 weeks Naviaux RK , et al. (2013)
Neurophysiology - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters - Not reported - - Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Restored Body temperature measurement 16 weeks Naviaux RK , et al. (2013)
Physiological parameters Core body temperature Refractory Body temperature measurement 5 months Naviaux RK , et al. (2013)
Physiological parameters Hormone levels No adverse effect Radioimmunoassay (ria) 15 weeks Naviaux RK , et al. (2013)
Physiological parameters Hormone levels Side effect Radioimmunoassay (ria) 15 weeks Naviaux RK , et al. (2013)
Physiological parameters Mitochondrial function Restored Mitochondrial respiratory chain enzyme analysis - Naviaux RK , et al. (2013)
Physiological parameters Respiratory function Side effect Respiration rate and pattern analysis - Naviaux RK , et al. (2013)
Physiological parameters Satiety response No adverse effect Food intake measurements Unreported Naviaux RK , et al. (2013)
Physiological parameters Satiety response No adverse effect Water intake measurements Unreported Naviaux RK , et al. (2013)
Repetitive behavior - Not reported - - Naviaux RK , et al. (2013)
Seizure - Not reported - - Naviaux RK , et al. (2013)
Sensory - Not reported - - Naviaux RK , et al. (2013)
Social behavior Social approach Restored Three-chamber social approach test 10 weeks Naviaux RK , et al. (2013)
PolyI:C Rescue Models(26 Models)
Sort By:
M_POLYIC_10_IN_B 2 Pharmaceutical JNJ47965567
M_POLYIC_10_IN_B 1 Genetic P2rx7
M_POLYIC_10_IN_B 1 Pharmaceutical Suramin
M_POLYIC_11_IN_B 2 Pharmaceutical Anti-IL17a
M_POLYIC_11_IN_B 3 Genetic Il17ra knockout
M_POLYIC_11_IN_B 2 Genetic Rorc knockout
M_POLYIC_11_IN_B 1 Procedural Somatosensory cortex activaton
M_POLYIC_11_IN_B 3 Procedural Somatosensory cortex inactivation
M_POLYIC_11_IN_B 1 Pharmaceutical Vancomycin
M_POLYIC_12_IN_B_SFB 1 Pharmaceutical Lipopolysaccharide
M_POLYIC_12_IN_B_SFB 1 Pharmaceutical Lipopolysaccharide; Anti-IL17a
M_POLYIC_12_IN_B_SFB 1 Pharmaceutical Recombinant interleukin 17a
M_POLYIC_13_IN_B_SFB 1 Genetic Il17a knockout
M_POLYIC_13_IN_B_SFB 1 Genetic Tcra knockout
M_POLYIC_16_IN_B_HGB 1 Pharmaceutical Anti-IL17a
M_POLYIC_26_IN_B 1 Pharmaceutical MgSO4
M_POLYIC_29_IN_B 1 Pharmaceutical Clonazepam
M_POLYIC_29_IN_B 1 Pharmaceutical JNJ47965567
M_POLYIC_29_IN_B 1 Genetic P2rx7
M_POLYIC_30_IN_B 1 Pharmaceutical Isoguvacine
M_POLYIC_31_IN_B 1 Pharmaceutical PLX5622
M_POLYIC_6_IN_B 1 Pharmaceutical Anti-IL6
M_POLYIC_6_IN_B 1 Genetic Il6 knockout
M_POLYIC_7_IN_B 1 Microbiome Bacteroides fragilis NCTC 9343
M_POLYIC_7_IN_B 2 Transplantation Bone marrow cells
M_POLYIC_9_IN_B 2 Pharmaceutical Suramin
Submit New Gene

Report an Error