Rescue Mouse Models 279 Rescue mouse models

Database updated on April 28, 2020

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Status Model Symbol Type of Model Type of Rescue Rescue Agent Number of Models
ADNPGeneticPharmaceuticalNAP3
ADNPGeneticPharmaceuticalSKIP2
ADNPGeneticPharmaceuticalNAP2
ALDH5A1GeneticPharmaceuticalCGP 353481
ALDH5A1GeneticPharmaceuticalVigabatrin1
ARHGAP33GeneticGeneticRho deleted Noma-gap protein1
ARHGAP33GeneticGeneticWild type Noma-gap protein1
ARID1BGeneticPharmaceuticalrecombinant human insulin like growth factor 11
ARID1BGeneticPharmaceuticalrecombinant mouse growth hormone1
BAIAP2GeneticPharmaceuticalMemantine1
BAIAP2GeneticPharmaceuticalMPEP1
BCKDKGeneticDietaryBranched-chain amino acid diet1
ADNPMultifactorialPharmaceuticalPACAP1
ARHGAP32GeneticPharmaceuticalClonazepam1
ARHGAP33GeneticGeneticOne Cdc42 copy knocked out2
ASH1LGeneticGeneticIl-6 knockout1
ATP1A3GeneticPharmaceuticalLithium1
BCKDKGeneticDietaryHigh protein diet1
CHD8GeneticGenetichuman CHD81
CHD8GeneticGeneticstablized Ctnnb1(S37A)1
CNTNAP2GeneticPharmaceuticalArginine vasopressin3
CDKL5GeneticPharmaceuticalMemantine1
CDKL5GeneticPharmaceuticalMemantine2
CHD2GeneticTransplantationMGE progenitor cells1
CHD7GeneticGeneticReelin gene expression1
CHD8GeneticPharmaceuticalCPI-4551
CHD8GeneticGeneticstablized Ctnnb1(S37A)1
CNTNAP2GeneticPharmaceuticalIsoguvacine1
CNTNAP2GeneticGeneticHuman CNTNAP21
CNTNAP2GeneticPharmaceuticalArginine vasopressin;L371,2571
BRINP1GeneticPharmaceuticalMethylphenidate1
CNTNAP2GeneticPharmaceuticalArginine vasopressin;Relcovaptan1
CNTNAP2GeneticGeneticDREADD-Oxytocin neurons1
CNTNAP2GeneticPharmaceuticalFenobam1
CNTNAP2GeneticPharmaceuticalFlumazenil1
CNTNAP2GeneticPharmaceuticalFluoxetine1
CNTNAP2GeneticPharmaceuticalLipopolysaccharide1
CNTNAP2GeneticPharmaceuticalRecombinant interleukin 17a1
CNTNAP2GeneticPharmaceuticalRo27-32252
CNTNAP2GeneticPharmaceuticalRo27-3225;L371,2571
CNTNAP2GeneticPharmaceuticalOxytocin4
CNTNAP2GeneticPharmaceuticalOxytocin;L371,2571
CNTNAP2GeneticPharmaceuticalRisperidone1
CNTNAP2GeneticProceduralParvalbumin neuron activation1
CNTNAP2GeneticProceduralPrimary somatosensory cortex dysgranular zone (S1DZ) optogenetic inactivation1
CNTNAP2GeneticProceduralPyramidal neuron activation1
CNTNAP4GeneticPharmaceuticalHaloperidol1
CNTNAP4GeneticPharmaceuticalIndipnol1
CUL3GeneticPharmaceuticalBCI-1211
CUL3GeneticGeneticSmyd3 knockdown1
CNTNAP4GeneticPharmaceuticalIndipnol1
CUL3GeneticGeneticChemogenetic reduction in activity of ventral hippocampal pyramidal neurons1
CUL3GeneticPharmaceutical4EGI-11
CYFIP1GeneticProceduralMotor training1
DIP2AGeneticGeneticCortactin-8KQ 1
DISC1GeneticPharmaceuticalClozapine1
DVL1GeneticPharmaceuticalCHIR990211
DVL1GeneticPharmaceuticalCHIR990211
EIF4EBP2GeneticPharmaceutical4EGI-11
EIF4EBP2GeneticGeneticshRNAs against Nlgn11
EIF4EBP2GeneticGeneticshRNAs against Nlgn21
FMR1GeneticGeneticinactivation of one allele of App gene1
DVL3GeneticPharmaceuticalCHIR990211
EIF4EGeneticPharmaceutical4EGI-11
FGFR2GeneticGeneticReinstatement of Fgfr21
FMR1GeneticPharmaceuticalIsoguvacine1
FMR1GeneticPharmaceuticalBW-723C86;MDL-11,9392
FMR1GeneticPharmaceuticalBW-723C86;MDL-11,939;SKF-81,297;Sulpiride1
FMR1GeneticPharmaceuticalCTEP2
FMR1GeneticPharmaceuticalSKF-81,297;Sulpiride2
FMR1GeneticPharmaceuticalCX-49451
FMR1GeneticPharmaceuticalJQ13
FMR1GeneticPharmaceuticalRecombinant interleukin 17a1
FMR1GeneticPharmaceuticalLithium2
FMR1GeneticPharmaceuticalMPEP1
FMR1GeneticPharmaceuticalMinocycline3
FMR1GeneticPharmaceuticalCX-4945;JQ11
FMR1GeneticPharmaceuticalLipopolysaccharide1
FMR1GeneticProceduralPrimary somatosensory cortex dysgranular zone (S1DZ) optogenetic inactivation1
FMR1GeneticPharmaceuticalCTEP2
FMR1GeneticPharmaceuticalFRAX48612
FMR1GeneticPharmaceuticalBumetanide2
FMR1GeneticPharmaceuticalMinocycline1
FMR1GeneticGeneticinactivation of one copy of S6K11
FMR1GeneticGeneticinactivation of S6K1 gene1
FOLH1GeneticDietaryLow folate diet2
GABRB3GeneticPharmaceuticalBaclofen1
GABRB3GeneticPharmaceuticalCarbamazepine1
GABRB3GeneticPharmaceuticalIsoguvacine1
GABRB3GeneticPharmaceuticalIsoguvacine1
GABRB3GeneticPharmaceuticalCGP 353481
GABRB3GeneticPharmaceuticalClonazepam1
GABRB3GeneticPharmaceuticalEthosuximide1
GABRB3GeneticPharmaceuticalTHIP1
GABRB3GeneticPharmaceuticalValproic acid1
GRIK4GeneticPharmaceuticalFluoxetine1
GRIK2GeneticPharmaceuticalFluoxetine1
GRIK4GeneticGeneticGrik-null1
GRIK4GeneticPharmaceuticalIEM14601
GRIK4GeneticPharmaceuticalTianeptine1
GRIK4GeneticPharmaceuticalUBP3101
GRIN1GeneticPharmaceuticalBaclofen1
GRIN1GeneticPharmaceuticalL-838,4171
GRIN1GeneticPharmaceuticalRisperidone1
IFNGGeneticPharmaceuticalDiazepam1
IFNGGeneticPharmaceuticalInterferon gamma1
LRRC4GeneticPharmaceuticalD-Cycloserine3
MECP2GeneticPharmaceutical7,8-Dihydroxyflavone1
MECP2GeneticPharmaceuticalAcetyl-L-carnitine1
MECP2GeneticPharmaceuticalCX-5461
MECP2GeneticPharmaceuticalD-Cycloserine1
MECP2GeneticPharmaceuticalAntalarmin1
MECP2GeneticGeneticone copy of Crh knocked out1
MECP2GeneticGeneticOne copy of Crhr1 knocked out1
MECP2GeneticPharmaceuticalCysteamine1
MECP2GeneticPharmaceuticalRU-4861
MECP2GeneticPharmaceuticalAcetyl-L-carnitine1
MECP2GeneticGeneticOne copy of Oprm1 knocked out1
MECP2GeneticGeneticReducing Mecp2 expression from transgene1
MECP2GeneticPharmaceuticalIsoguvacine1
MECP2GeneticPharmaceuticalMidazolam1
MECP2GeneticGeneticMECP2-dNIC1
MECP2GeneticGeneticReinstatement of Mecp22
MECP2GeneticPharmaceuticalRU-4861
GABRB2GeneticPharmaceuticalDiazepam2
GABRB2GeneticPharmaceuticalRisperidone1
MECP2GeneticGeneticGabrb31
MECP2GeneticPharmaceuticalIsoguvacine1
GABRB2GeneticPharmaceuticalRisperidone1
MECP2GeneticPharmaceuticalIsoguvacine1
MECP2GeneticGeneticMECP2-dNIC1
MECP2GeneticPharmaceuticalD-Cycloserine1
MECP2GeneticPharmaceuticalFenobam1
MECP2GeneticPharmaceuticalSCH-233901
MECP2GeneticPharmaceuticalSCH-391661
MEF2CGeneticPharmaceuticalMemantine1
MEF2CGeneticPharmaceuticalNitroSynapsin1
MIR137GeneticGeneticAblation of Pde10a1
MIR137GeneticPharmaceuticalPapaverine1
MTHFRGeneticDietaryC1 enriched diet2
NEGR1GeneticGeneticFgfr2 cDNA1
NEGR1GeneticGeneticReinstatement of Negr11
NLGN3GeneticGeneticDIO-NL3 transgene in nucleus accumbens1
NLGN3GeneticGeneticNlgn34
NLGN3GeneticGeneticNLGN31
NLGN3GeneticGeneticNlgn3 reexpression1
NLGN3GeneticGeneticOptogenetic activation of Pvalb interneurons1
NLGN3GeneticPharmaceuticalACEA1
NLGN3GeneticPharmaceuticalHU-2101
NLGN3GeneticPharmaceuticalQuinpirole1
NLGN3GeneticPharmaceuticalURB5971
OPRM1GeneticBehavioralDouble mothering - social enrichment1
OPRM1GeneticPharmaceuticalOxytocin1
OXTRGeneticPharmaceuticalCocaine1
OXTRGeneticDietaryLactobacillus reuteri1
OXTRGeneticPharmaceuticalOxytocin1
OXTRGeneticPharmaceuticalArginine vasopressin1
OXTRGeneticPharmaceuticalOxytocin1
OXTGeneticPharmaceuticalArginine vasopressin1
OXTGeneticPharmaceuticalOta-vasotocin1
OXTGeneticPharmaceuticalOxytocin1
OXTGeneticGenetic; InducedCB1 receptor antagonist1
OXTGeneticGeneticPregnancy1
PLPPR4GeneticGeneticH253K-PLPPR41
PAK2GeneticGeneticPhospho-cofilin peptide1
PCDH10GeneticPharmaceuticalD-Cycloserine1
PLPPR4GeneticGeneticLPA2R1
PLPPR4GeneticGeneticPLPPR41
POGZGeneticPharmaceuticalNBQX1
POGZGeneticPharmaceuticalPerampanel1
PTCHD1GeneticPharmaceuticalAmphetamine1
PTCHD1GeneticPharmaceuticalEBIO1
PTENGeneticBiologicalInterneuron1
PRKDCGeneticTransplantationLymphocytes1
PTENGeneticPharmaceuticalRapamycin2
PTENGeneticGeneticRictor antisense oligonucleotide1
PTENGeneticGeneticRictor conditional knockout1
PTENGeneticGeneticRptor conditional knockout1
RAI1GeneticProceduralPFC activation2
RAI1GeneticGeneticReinstatement of Rai14
PTENGeneticDietaryFasting1
RELNGeneticPharmaceuticalEstradiol1
SCN1AGeneticPharmaceuticalClonazepam1
SHANK2GeneticPharmaceuticalCDPPB2
SHANK2GeneticPharmaceuticalD-Cycloserine1
SHANK2GeneticPharmaceuticalClioquinol1
SCN2AGeneticBiologicalAmpalex1
SHANK2GeneticPharmaceuticalD-Cycloserine1
SHANK2GeneticPharmaceuticalMemantine4
SHANK3GeneticPharmaceuticalCDPPB2
SHANK3GeneticPharmaceuticalMPEP1
SHANK3GeneticPharmaceuticalInsulin-like growth factor 12
SHANK3GeneticPharmaceuticalInsulin-like growth factor 1 peptide derivative1
SHANK2GeneticPharmaceuticalL-838,4171
SHANK2GeneticPharmaceuticalL-838,4171
SHANK3GeneticGeneticReinstatement of Shank31
SHANK3GeneticGeneticReinstatement of Shank31
SHANK3GeneticProceduralACC chemogenetic activation1
SHANK3GeneticProceduralACC optogenetic activation1
SHANK3GeneticPharmaceuticalCX-5464
SHANK3GeneticPharmaceuticalLipopolysaccharide1
SHANK3GeneticGeneticReinstatement of Shank32
SHANK3GeneticProceduralPrimary somatosensory cortex dysgranular zone (S1DZ) optogenetic inactivation1
SHANK3GeneticPharmaceuticalIsoguvacine3
SHANK3GeneticTransplantationLactobacillus reuteri2
SHANK3GeneticGeneticReinstatement of Shank33
SHANK3GeneticGeneticReinstatement of Shank31
SHANK3GeneticDietaryZinc1
SHANK3GeneticPharmaceuticalCocaine1
SHANK3GeneticPharmaceuticalCX-5461
SHANK3GeneticDietaryLactobacillus reuteri2
SHANK3GeneticPharmaceuticalOxytocin1
SHANK3GeneticPharmaceutical7,8-Dihydroxyflavone1
SHANK3GeneticPharmaceuticalD-Cycloserine2
SHANK3GeneticGeneticconstititutively active Rac11
SHANK3GeneticPharmaceuticalTG0031
SHANK3GeneticPharmaceuticalAripiprazole1
SHANK3GeneticGeneticbeta-catenin sh RNA1
SHANK3GeneticPharmaceuticalClozapine1
SHANK3GeneticPharmaceuticalFluoxetine1
SHANK3GeneticGeneticHdac2 shRNA2
SHANK3GeneticPharmaceuticalPhospho-cofilin peptide3
SHANK3GeneticPharmaceuticalRomidepsin4
SHANK3GeneticPharmaceuticalRisperidone1
SHANK3GeneticPharmaceuticalTG0031
SHANK3GeneticPharmaceuticalTrichostatin A1
SHANK3GeneticPharmaceuticalValproic acid1
SLC1A2GeneticPharmaceuticalDesloratadine1
SLC1A2GeneticPharmaceuticalFluoxetine2
SLC1A2GeneticPharmaceuticalMemantine1
SLC6A3GeneticPharmaceuticalClozapine1
SLC6A3GeneticPharmaceuticalHaloperidol1
SLC6A3GeneticPharmaceuticalPregnenolone1
SLC6A4GeneticGeneticAblation of Mapk141
SLC6A4GeneticPharmaceuticalMW1082
SLC6A4GeneticPharmaceuticalMW1502
Slc30a3GeneticPharmaceuticalMinocycline1
SLC33A1GeneticGeneticSuppression of the human SLC33A1 human transgene1
SLC6A4GeneticPharmaceuticalPrucalopride1
SLC7A5GeneticPharmaceuticalBranched-chained amino acids1
ST8SIA2GeneticPharmaceuticalD-Cycloserine3
TAOK2GeneticGeneticTAOK2ab-A135P1
TAOK2GeneticGeneticTAOK2b-P10221
TAOK2GeneticGeneticWT-TAOK2ab1
STXBP1GeneticPharmaceuticalLevetiracetam2
SYN2GeneticPharmaceuticalTHIP1
TBR1GeneticPharmaceuticalD-Cycloserine2
TBR1GeneticGeneticin utero electroporation of micro-RNA- Cdh8 and Ntng11
TBR1GeneticGeneticClioquinone1
TBR1GeneticPharmaceuticalD-Cycloserine1
TCF4GeneticGeneticHdac2 shRNAs1
TCF4GeneticPharmaceuticalSAHA1
TBR1GeneticGeneticReinstatement of Wnt7b2
TRIM32GeneticPharmaceutical3BDO1
TRIM32GeneticPharmaceuticalClonazepam1
TRIM32GeneticPharmaceuticalM/LGE progenitors1
TERTGeneticPharmaceuticalMemantine1
TRPC6GeneticGeneticTRPC6-WTR-sh-RNA1
TSC1GeneticProceduralLeft crus I Purkinje neuron stimulation1
TSC1GeneticProceduralRight crus I Purkinje neuron stimulation1
TSC1GeneticPharmaceuticalD-Cycloserine1
TSC1GeneticPharmaceuticalFenobam1
TSC1GeneticPharmaceuticalSCH-233901
TSC1GeneticPharmaceuticalSCH-391661
TSC1GeneticPharmaceuticalRapamycin1
TSC1GeneticPharmaceuticalRapamycin1
TSC1GeneticPharmaceuticalRapamycin3
TSC1GeneticPharmaceuticalRapamycin1
TSC1GeneticPharmaceuticalRapamycin6
TSC2GeneticPharmaceuticalRapamycin1
TSC2GeneticPharmaceuticalRapamycin4
UBE3AGeneticGeneticReinstatement of Ube3a in GABAergic neurons1
UBE3AGeneticGeneticReinstatement of Ube3a in glutamatergic neurons1
UBE3AMultifactorialGeneticCbln1 expression1
UBE3AGeneticPharmaceuticalTHIP2
UPF2Genetic PharmaceuticalCyclophosphamide1
UPF2Genetic PharmaceuticalMinocycline1
UBE3AGeneticPharmaceuticalApamin1
UPF3BGeneticPharmaceuticalHaloperidol1
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We are pleased to announce some changes to the ongoing curation of the data in SFARI Gene. In the context of a continued effort to develop the human gene module and its manually curated list of autism risk genes, we are modifying other aspects of the site to focus on the information that is of greatest interest to the research community. The version of SFARI Gene that has been developed until now will be frozen and will remain available as “SFARI Gene Archive”. Please see the announcement for more details.
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