Rescue Animal Models 249 Rescue animal models

Database updated on August 13, 2018

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Status Model Symbol Type of Model Type of Rescue Rescue Agent Model Species Number of Models
SLC6A3GeneticPharmaceuticalclozapineMus musculus2
SLC6A3GeneticPharmaceuticalHaloperidolMus musculus2
SLC6A3GeneticPharmaceuticalpregnenoloneMus musculus2
SLC6A3GeneticPharmaceuticalClonidineRattus norvegicus1
SLC6A3GeneticPharmaceuticalFluoxetineRattus norvegicus1
SLC6A3GeneticPharmaceuticalQuinpiroleRattus norvegicus1
SHANK2GeneticPharmaceutical3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB)Mus musculus2
SHANK2GeneticPharmaceuticalD-cycloserineMus musculus2
SHANK2GeneticPharmaceuticalClioquinoleMus musculus2
SHANK2GeneticPharmaceuticalL838417Mus musculus1
SHANK2GeneticPharmaceuticalL838417Mus musculus1
SLC6A4GeneticPharmaceuticalprucaloprideMus musculus1
GRIN1GeneticPharmaceuticalBaclofenMus musculus2
GRIN1GeneticPharmaceuticalL-838,417Mus musculus1
GRIN1GeneticPharmaceuticalRisperidoneMus musculus2
IFNGGeneticPharmaceuticalDiazepamMus musculus1
IFNGGeneticPharmaceuticalRecombinant interferon gamma proteinMus musculus1
PTENGeneticGeneticS6k lossDrosophila melanogaster1
PTENGeneticPharmaceuticalRapamycinMus musculus2
DEAF1GeneticGeneticpaternal DEAF1Drosophila melanogaster1
DEAF1GeneticGeneticpaternal DEAF1Drosophila melanogaster1
TSC2GeneticPharmaceuticalEverolimusRattus norvegicus2
TSC2GeneticPharmaceuticalrapamycinMus musculus8
TSC2GeneticPharmaceuticalrapamycinMus musculus2
MECP2GeneticGeneticMECP2-dNICMus musculus1
MECP2GeneticPharmaceuticalRU486 (glucocorticoid receptor antagonist)Mus musculus1
MECP2GeneticGeneticReducing Mecp2 expression from transgeneMus musculus1
MECP2GeneticPharmaceuticalCysteamineMus musculus1
MECP2GeneticPharmaceuticalRU486 (glucocorticoid receptor antagonist)Mus musculus1
MECP2GeneticPharmaceuticalAmpakine(CX546)Mus musculus1
MECP2GeneticPharmaceutical7,8 Dihyroxyflavone Mus musculus1
MECP2GeneticPharmaceuticalAcetyl L carnitineMus musculus1
MECP2GeneticPharmaceuticalD-cycloserineMus musculus1
MECP2GeneticPharmaceuticalAntalarmin (CRH receptor antagonist)Mus musculus1
MECP2GeneticGeneticone copy of Crh knocked outMus musculus1
MECP2GeneticGeneticOne copy of Crhr1 knocked outMus musculus1
MECP2GeneticGeneticOne copy of Oprm1 knocked outMus musculus1
MECP2GeneticPharmaceuticalAcetyl L carnitineMus musculus1
MECP2GeneticGeneticHuC mecp2Danio rerio1
MECP2GeneticGeneticmecp2 mRNADanio rerio1
MECP2GeneticGeneticrobo mRNA; sema5b mRNADanio rerio1
MECP2GeneticGeneticrobo2 mRNADanio rerio1
MECP2GeneticGeneticsema5b mRNADanio rerio1
MECP2GeneticGeneticmecp2 mRNADanio rerio2
MECP2GeneticGenetictnfa mRNADanio rerio1
MECP2GeneticGeneticMECP2-dNICMus musculus1
OPRM1GeneticPharmaceuticalOxytocinMus musculus2
OPRM1GeneticBehavioralDouble mothering - social enrichmentMus musculus1
ATP1A3GeneticPharmaceuticalLithium carbonateMus musculus2
MEF2CGeneticPharmaceuticalmemantineMus musculus1
MEF2CGeneticPharmaceuticalNitroSynapsinMus musculus1
VRK3Genetic Pharmaceutical DHFMus musculus 3
FOLH1GeneticDietaryLow folateMus musculus1
PCDH19GeneticGenetichPCDH19Rattus norvegicus1
SCN1AGeneticPharmaceuticalbenzodiazepineMus musculus2
SCN1AGeneticPharmaceuticalMethylphenidateRattus norvegicus2
SLC1A2GeneticPharmaceuticalDesloratadineMus musculus2
SLC1A2GeneticPharmaceuticalFluoxetineMus musculus4
SLC1A2GeneticPharmaceuticalMemantineMus musculus2
RELNGeneticPharmaceuticalEstradiolMus musculus1
STXBP1GeneticPharmaceuticallevetiracetamMus musculus 2
TERTGeneticPharmaceuticalMemantineMus musculus1
ARID1BGeneticPharmaceuticalrecombinant human insulin like growth factor 1Mus musculus1
ARID1BGeneticPharmaceuticalrecombinant mouse growth hormoneMus musculus1
NRXN1GeneticGeneticAmygdala activationRattus norvegicus1
ALDH5A1GeneticPharmaceuticalCGP 35348Mus musculus1
ALDH5A1GeneticPharmaceuticalvigabatrinMus musculus1
ADNPGeneticPharmaceuticalNAPMus musculus3
ADNPGeneticPharmaceuticalSKIPMus musculus2
BCKDKGeneticDietaryhigh protein dietMus musculus2
BCKDKGeneticDietarybranched-chain amino acid dietMus musculus1
DISC1GeneticGeneticClozapineMus musculus1
PCDH10GeneticPharmaceuticald-cycloserine (DCS)Mus musculus2
OXTGeneticPharmaceuticalAVPMus musculus1
OXTGeneticPharmaceuticalOxytocinMus musculus2
OXTGeneticPharmaceuticalOxytocin receptor antagonistMus musculus2
OXTGeneticGenetic; Induced CB1 receptor antagonistMus musculus1
OXTGeneticGeneticPregnancyMus musculus1
EIF4EGeneticPharmaceutical4EGI-1Mus musculus1
TCF4GeneticGeneticHdac2 shRNAsMus musculus1
TCF4GeneticPharmaceuticalSAHA (suberoylanilide hydroxamic acid)Mus musculus1
TCF4GeneticPharmaceuticalA803476Rattus norvegicus1
TCF4GeneticPharmaceuticalUCL2077Rattus norvegicus1
PRKDCGeneticTransplantationWild -type lymphocytesMus musculus1
NLGN3GeneticGeneticNLGN3Mus musculus1
NLGN3GeneticGeneticOptogenetic activation of Pvalb interneuronsMus musculus1
PTCHD1GeneticPharmaceuticalAmphetamineMus musculus1
PTCHD1GeneticPharmaceutical1-ethyl-benzimidazolinone (1 - EBIO)Mus musculus1
TAOK2GeneticGeneticTAOK2ab-A135P Mus musculus 1
TAOK2GeneticGeneticTAOK2b-P1022Mus musculus 1
TAOK2GeneticGeneticWT-TAOK2abMus musculus 1
GRIK2GeneticPharmaceuticalFluoxetineMus musculus2
GRIK4GeneticPharmaceuticalFlouxetineMus musculus1
GRIK4GeneticPharmaceuticalTianeptineMus musculus1
DVL1GeneticPharmaceuticalCHIR99021Mus musculus1
DVL3GeneticPharmaceuticalCHIR99021Mus musculus1
DVL1GeneticPharmaceuticalCHIR99021Mus musculus1
DVL1GeneticPharmaceuticalCHIR99021Mus musculus1
DVL3GeneticPharmaceuticalCHIR99021Mus musculus1
RLIMGeneticGENETIChu-rlim-wt mRNADanio rerio1
RLIMGeneticGENETICrlim^Arg365CysDanio rerio1
RLIMGeneticGENETICrlim^Arg387CysDanio rerio1
RLIMGeneticGENETICrlim^Arg599CysDanio rerio1
RLIMGeneticGENETICrlim^Arg611CysDanio rerio1
RLIMGeneticGENETICrlim^Asn178ThrDanio rerio1
RLIMGeneticGENETICrlim^Pro587ArgDanio rerio1
RLIMGeneticGENETICrlim^Pro77LeuDanio rerio1
RLIMGeneticGENETICrlim^Tyr356CysDanio rerio1
ARHGAP32GeneticPharmaceuticalClonazepamMus Musculus1
ARHGAP33GeneticGeneticOne Cdc42 copy knocked outMus musculus2
ARHGAP33GeneticGeneticRho deleted Noma-gap proteinMus musculus1
ARHGAP33GeneticGeneticWild type Noma-gap proteinMus musculus1
TSC1GeneticPharmaceuticalrapamycinMus musculus2
TSC1GeneticPharmaceuticalrapamycinMus musculus1
TSC1GeneticPharmaceuticalrapamycinMus musculus3
TSC1GeneticPharmaceuticalrapamycinMus musculus1
TSC1GeneticProceduralLeft crus I Purkinje neuron stimulationMus musculus1
TSC1GeneticProceduralRight crus I Purkinje neuron stimulationMus musculus1
RPL10Genetic GenetichRPL10Danio rerio 1
RPL10Genetic GenetichRPL10-H213QDanio rerio 1
RPL10Genetic GenetichRPL10-K78EDanio rerio 1
RPL10Genetic GenetichRPL10-L206MDanio rerio 1
RPL10Genetic GenetichRPL10-S202NDanio rerio 1
PAX6GeneticPharmaceuticalClozapineRattus norvegicus2
EIF4EBP2GeneticPharmaceutical4EGI-1Mus musculus1
EIF4EBP2GeneticGeneticshRNAs against Nlgn1Mus musculus1
EIF4EBP2GeneticGeneticshRNAs against Nlgn2Mus musculus1
GABRB3GeneticPharmaceuticalBaclofenMus musculus2
GABRB3GeneticPharmaceuticalCarbamazepineMus musculus2
GABRB3GeneticPharmaceuticalCGP 35348Mus musculus1
GABRB3GeneticPharmaceuticalClonazepamMus musculus2
GABRB3GeneticPharmaceuticalethosuximideMus musculus2
GABRB3GeneticPharmaceuticalTHIP (gaboxadol)Mus musculus1
GABRB3GeneticPharmaceuticalvalproic acid (VPA)Mus musculus1
RHEBGeneticPharmaceuticalRapamycinDanio rerio1
RHEBGeneticPharmaceuticalRapamycinDanio rerio1
RHEBGeneticPharmaceuticalRapamycinDanio rerio1
FMR1GeneticPharmaceuticalLithiumMus musculus2
FMR1GeneticPharmaceuticalMPEPMus musculus1
FMR1GeneticGeneticinactivation of one allele of App geneMus musculus1
FMR1GeneticPharmaceuticalminocyclineMus musculus2
FMR1GeneticPharmaceutical2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (CTEP).Mus musculus2
FMR1GeneticPharmaceutical5HT 2B-R agonist BW723C86 (5mg/kg) and 5HT 2A-R-Antagonist MDL11939 (1mg/kg)Mus musculus2
FMR1GeneticPharmaceutical5HT 2B-R agonist BW723C86 (0.05mg/kg) and 5HT 2A-R-Antagonist MDL11939 (0.01mg/kg)The D1- R agonist SKF81297 (0.05mg/kg) and D2-R antagonist Sulpiride (0.25mg/kg)Mus musculus1
FMR1GeneticPharmaceuticalD1- R agonist SKF81297 (5mg/kg) and D2-R antagonist Sulpiride (25mg/kg)Mus musculus2
FMR1GeneticPharmaceuticalCX-4945Mus musculus2
FMR1GeneticPharmaceuticalJQ1Mus musculus3
FMR1GeneticPharmaceuticalBumetanideMus musculus1
FMR1GeneticGeneticinactivation of S6K1 geneMus musculus1
FMR1GeneticGeneticinactivation of one copy of S6K1Mus musculus1
FMR1GeneticPharmaceuticalFRAX486Mus musculus6
FMR1GeneticPharmaceuticalminocyclineMus musculus1
ATG7GeneticPharmaceuticalRapamycinMus musculus2
SYN2GeneticPharmaceuticalTHIPMus musculus1
BRINP1GeneticPharmaceuticalMethylphenidateMus musculus2
KCTD13GeneticGeneticBBS7Danio rerio1
KCTD13GeneticGeneticcep290 RNADanio rerio1
KCTD13GeneticGeneticcep290 MODanio rerio1
CEP290GeneticGeneticcep290 MODanio rerio1
KCTD13GeneticGeneticBBS7Danio rerio1
KCTD13GeneticGeneticCEP290 RNADanio rerio1
TBR1GeneticPharmaceuticalD-cycloserineMus musculus3
TBR1GeneticGeneticin utero electroporation of micro-RNA- Cdh8 and Ntng1Mus musculus2
TBR1GeneticGeneticClioquinoneMus musculus2
KCNJ10GeneticGeneticR18Q-Kir4.1Danio rerio1
KCNJ10GeneticGeneticR271C-Kir4.1Danio rerio1
KCNJ10GeneticGeneticR348H-Kir4.1Danio rerio1
KCNJ10GeneticGeneticV84M-Kir4.1Danio rerio1
KCNJ10GeneticGeneticwt-Kir4.1Danio rerio1
KCNJ10GeneticGeneticwt-Hu-Kir4.1mRNADanio rerio1
TRPC6GeneticGeneticTRPC6-WTR-sh-RNAMus musculus1
CHD7GeneticGeneticReelin gene expressionMus musculus1
UBE3AGeneticGeneticUbe3a^+Drosophila melanogaster1
UBE3AGeneticGeneticUbe3a^C941ADrosophila melanogaster1
UBE3AGeneticPharmaceuticalApaminMus musculus1
UBE3AGeneticPharmaceuticalTHIP (gaboxadol)Mus musculus4
UBE3AGeneticGeneticExpression of drrlDrosophila melanogaster1
UBE3AGeneticGeneticReinstate Ube3aDrosophila melanogaster2
UBE3AGeneticGeneticExpression of human Ube3aDrosophila melanogaster1
UBE3AGeneticGeneticExpression of Ube3a-C941ADrosophila melanogaster1
UBE3AGeneticGeneticExpression of human Ube3aDrosophila melanogaster1
UBE3AGeneticGeneticExpression of human Ube3aDrosophila melanogaster1
UBE3AGeneticGeneticReinstatement of Ube3a in glutamatergic neuronsMus musculus1
UBE3AGeneticGeneticReinstatement of Ube3a in GABAergic neuronsMus musculus1
UBE3AMultifactorialGeneticCbln1 expressionMus musculus1
PLPPR4GeneticGeneticLPA2RMus musculus1
PLPPR4GeneticGeneticPLPPR4Mus musculus1
PLPPR4GeneticGeneticH253K-PLPPR4Mus musculus1
AVPGeneticPharmaceuticalClozapineRattus norvegicus4
AVPGeneticPharmaceuticalHaloperidolRattus norvegicus2
AVPGeneticPharmaceuticalPD149163Rattus norvegicus2
BAIAP2GeneticPharmaceuticalmemantineMus musculus1
BAIAP2GeneticPharmaceuticalMPEPMus musculus1
ASH1LGeneticGeneticIl-6 knockoutMus musculus1
SLC7A5GeneticPharmaceuticalBCAAMus musculus1
HDCGeneticPharmaceuticalJNJ5207852Mus musculus1
HDCPharmaceutical interventionPharmaceuticalhaloperidolMus musculus4
HDCPharmaceutical interventionPharmaceuticalhistamineMus musculus2
HDCPharmaceutical interventionPharmaceuticalhaloperidolMus musculus4
HDCPharmaceutical interventionPharmaceuticalJNJ5207852Mus musculus1
HDCPharmaceutical interventionPharmaceuticalJNJ5207852Mus musculus2
HDCPharmaceutical interventionGeneticActivity-dependent and neuronal specific activation of Gi proteinMus musculus1
CICGeneticPharmaceuticalAmphetamineMus musculus4
SLC33A1GeneticGeneticSuppression of the human SLC33A1 human transgeneMus musculus1
CNTNAP2GeneticGeneticHuman CNTNAP2Mus musculus1
CNTNAP2GeneticPharmaceuticalRisperidoneMus musculus1
CNTNAP2GeneticPharmaceuticalArginine VasopressinMus musculus4
CNTNAP2GeneticGeneticDREADD-Oxytocin neuronsMus musculus1
CNTNAP2GeneticPharmaceuticalFenobamMus musculus1
CNTNAP2GeneticPharmaceuticalFlumazenilMus musculus1
CNTNAP2GeneticPharmaceuticalFluoxetineMus musculus1
CNTNAP2GeneticPharmaceuticalMelanocortin 4 receptor agonistMus musculus2
CNTNAP2GeneticPharmaceuticalOxytocinMus musculus4
CNTNAP2GeneticProceduralParvalbumin neuron activationMus musculus1
CNTNAP2GeneticProceduralPyramidal neuron activationMus musculus1
CNTNAP4GeneticPharmaceuticalHaloperidolMus musculus2
CNTNAP4GeneticPharmaceuticalIndipnolMus musculus2
CNTNAP4GeneticPharmaceuticalIndipnolMus musculus2
OXTRGeneticPharmaceuticalVasopressinMus musculus1
OXTRGeneticPharmaceuticalOxytocinMus musculus2
SHANK3GeneticBiologicalLactobacillus reuteri Mus musculus1
SHANK3GeneticPharmaceuticalRomidepsinMus musculus4
SHANK3GeneticPharmaceuticalAripiprazoleMus musculus1
SHANK3GeneticPharmaceuticalClozapineMus musculus1
SHANK3GeneticGeneticbeta-catenin sh RNAMus musculus1
SHANK3GeneticPharmaceuticalFluoxetineMus musculus1
SHANK3GeneticGeneticHdac2 shRNAMus musculus2
SHANK3GeneticPharmaceuticalRisperidoneMus musculus1
SHANK3GeneticPharmaceuticalTSAMus musculus1
SHANK3GeneticPharmaceuticalVPAMus musculus1
SHANK3GeneticPharmaceuticalOxytocinRattus norvegicus1
SHANK3GeneticPharmaceuticalOxytocinRattus norvegicus1
NF1GeneticGeneticReinstate Nf1Drosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in central clock neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in central brain neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in cholinergic neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in DH44 producing neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in DN1 clock neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in DN1 clock neurons and nonclock neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in pars intercerebralisDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in Kenyon cellsDrosophila melanogaster2
NF1GeneticGeneticReinstate Nf1 in lateral-protocerebrumDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in monoaminergic neuronsDrosophila melanogaster2
NF1GeneticGeneticReinstate Nf1 in mushroom bodyDrosophila melanogaster2
NF1GeneticGeneticReinstate Nf1 in mushroom body-gamma neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in peptidergic neuronsDrosophila melanogaster1
NF1GeneticGeneticReinstate Nf1 in whole brainDrosophila melanogaster1
UPF3BGeneticPharmaceuticalHaloperidolMus musculus1
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