CUL3Cullin 3
Autism Reports / Total Reports
27 / 37Rare Variants / Common Variants
52 / 1Chromosome Band
2q36.2Associated Disorders
ID, EPSGenetic Category
Rare Single Gene Mutation, Genetic Association, FunctionalRelevance to Autism
Two de novo loss-of-function (LoF) mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329). A two-stage analysis of rare de novo and inherited coding variants in 42,607 ASD cases, including 35,130 new cases from the SPARK cohort, in Zhou et al., 2022 identified CUL3 as a gene reaching exome-wide significance (P < 2.5E-06).
Molecular Function
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation.
External Links
SFARI Genomic Platforms
Reports related to CUL3 (37 Reports)
| # | Type | Title | Author, Year | Autism Report | Associated Disorders |
|---|---|---|---|---|---|
| 1 | Support | Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics | Bennett EJ , et al. (2010) | No | - |
| 2 | Primary | Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations | O'Roak BJ , et al. (2012) | Yes | - |
| 3 | Support | Rate of de novo mutations and the importance of father's age to disease risk | Kong A , et al. (2012) | Yes | - |
| 4 | Recent Recommendation | Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases | Canning P , et al. (2013) | No | - |
| 5 | Recent Recommendation | Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4 | Shibata S , et al. (2013) | No | - |
| 6 | Recent Recommendation | Synaptic, transcriptional and chromatin genes disrupted in autism | De Rubeis S , et al. (2014) | Yes | - |
| 7 | Support | Large-scale discovery of novel genetic causes of developmental disorders | Deciphering Developmental Disorders Study (2014) | No | - |
| 8 | Support | Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders | Codina-Sol M , et al. (2015) | Yes | - |
| 9 | Recent Recommendation | Low load for disruptive mutations in autism genes and their biased transmission | Iossifov I , et al. (2015) | Yes | - |
| 10 | Recent Recommendation | Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor | McGourty CA , et al. (2016) | No | - |
| 11 | Support | De novo genic mutations among a Chinese autism spectrum disorder cohort | Wang T , et al. (2016) | Yes | - |
| 12 | Support | The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies | Redin C , et al. (2016) | No | - |
| 13 | Support | Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases | Stessman HA , et al. (2017) | Yes | - |
| 14 | Support | Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder | C Yuen RK et al. (2017) | Yes | - |
| 15 | Positive Association | Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection | Pardias AF , et al. (2018) | No | - |
| 16 | Support | Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model | Guo H , et al. (2018) | Yes | - |
| 17 | Support | Whole genome sequencing and variant discovery in the ASPIRE autism spectrum disorder cohort | Callaghan DB , et al. (2019) | Yes | - |
| 18 | Support | Autism-associated missense genetic variants impact locomotion and neurodevelopment in Caenorhabditis elegans | Wong WR , et al. (2019) | Yes | - |
| 19 | Support | Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling | Kikuma K , et al. (2019) | No | - |
| 20 | Support | Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks | Ruzzo EK , et al. (2019) | Yes | - |
| 21 | Support | Meta-Analyses Support Previous and Novel Autism Candidate Genes: Outcomes of an Unexplored Brazilian Cohort | da Silva Montenegro EM , et al. (2019) | Yes | - |
| 22 | Support | De novo variants in CUL3 are associated with global developmental delays with or without infantile spasms | Nakashima M et al. (2020) | No | ID, epilepsy/seizures |
| 23 | Support | Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders | Wang T et al. (2020) | Yes | - |
| 24 | Support | - | Morandell J et al. (2021) | Yes | - |
| 25 | Support | - | Mahjani B et al. (2021) | Yes | - |
| 26 | Support | - | Li D et al. (2022) | Yes | - |
| 27 | Support | - | Zhou X et al. (2022) | Yes | - |
| 28 | Support | - | Rapanelli M et al. (2023) | Yes | - |
| 29 | Support | - | Vincent KM et al. (2023) | No | - |
| 30 | Recent Recommendation | - | Weinschutz Mendes H et al. (2023) | Yes | - |
| 31 | Support | - | Qian M et al. (2023) | Yes | - |
| 32 | Support | - | Xia QQ et al. (2023) | Yes | - |
| 33 | Support | - | Cirnigliaro M et al. (2023) | Yes | - |
| 34 | Support | - | Gao N et al. (2023) | Yes | - |
| 35 | Support | - | Samantha J Tener et al. (2024) | Yes | - |
| 36 | Support | - | Qiang-Qiang Xia et al. (2024) | Yes | - |
| 37 | Support | - | Laura E Burnett et al. () | Yes | - |
Rare Variants (52)
| Status | Allele Change | Residue Change | Variant Type | Inheritance Pattern | Parental Transmission | Family Type | PubMed ID | Author, Year |
|---|---|---|---|---|---|---|---|---|
| - | - | translocation | De novo | - | - | 27841880 | Redin C , et al. (2016) | |
| c.571G>T | p.Glu191Ter | stop_gained | Unknown | - | - | 34968013 | Li D et al. (2022) | |
| c.614C>G | p.Ser205Ter | stop_gained | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.757C>T | p.Arg253Ter | stop_gained | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.1008+1G>T | - | splice_site_variant | De novo | - | - | 33004838 | Wang T et al. (2020) | |
| c.1654C>T | p.Arg552Ter | stop_gained | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.1550C>G | p.Ser517Ter | stop_gained | De novo | - | - | 35982159 | Zhou X et al. (2022) | |
| c.1636C>T | p.Arg546Ter | stop_gained | De novo | - | - | 22914163 | Kong A , et al. (2012) | |
| c.379-2A>G | - | splice_site_variant | De novo | - | - | 36710200 | Vincent KM et al. (2023) | |
| c.1669C>A | p.Pro557Thr | missense_variant | Unknown | - | - | 34968013 | Li D et al. (2022) | |
| c.185G>A | p.Arg62His | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.245G>A | p.Arg82Gln | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.190A>G | p.Met64Val | missense_variant | De novo | - | - | 35982159 | Zhou X et al. (2022) | |
| c.320T>C | p.Phe107Ser | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.475C>T | p.Arg159Cys | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.1327G>A | p.Ala443Thr | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.1802C>T | p.Ser601Phe | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.2110G>A | p.Asp704Asn | missense_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.1661T>C | p.Leu554Pro | missense_variant | De novo | - | - | 35982159 | Zhou X et al. (2022) | |
| c.2281C>T | p.Arg761Cys | missense_variant | De novo | - | - | 35982159 | Zhou X et al. (2022) | |
| c.67-22145del | - | frameshift_variant | De novo | - | - | 32341456 | Nakashima M et al. (2020) | |
| c.2065A>T | p.Lys689Ter | stop_gained | De novo | - | Simplex | 37026922 | Qian M et al. (2023) | |
| T>C | p.? | splice_site_variant | Familial | - | Multiplex | 28263302 | C Yuen RK et al. (2017) | |
| c.793G>T | p.Glu265Ter | splice_site_variant | De novo | - | - | 27824329 | Wang T , et al. (2016) | |
| c.1046A>G | p.Gln349Arg | missense_variant | Unknown | - | - | 34615535 | Mahjani B et al. (2021) | |
| c.854T>C | p.Val285Ala | missense_variant | De novo | - | - | 32341456 | Nakashima M et al. (2020) | |
| c.736G>T | p.Glu246Ter | stop_gained | De novo | - | Simplex | 22495309 | O'Roak BJ , et al. (2012) | |
| c.1961C>T | p.Pro654Leu | missense_variant | De novo | - | Simplex | 30564305 | Guo H , et al. (2018) | |
| c.541C>T | p.Arg181Ter | stop_gained | Unknown | - | Unknown | 25363760 | De Rubeis S , et al. (2014) | |
| c.1644+2T>C | - | splice_site_variant | Unknown | - | Unknown | 25363760 | De Rubeis S , et al. (2014) | |
| c.67-22109A>G | - | missense_variant | Unknown | - | Simplex | 31038196 | Callaghan DB , et al. (2019) | |
| c.521del | p.Met174ArgfsTer11 | frameshift_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.917del | p.Gly306ValfsTer25 | frameshift_variant | De novo | - | - | 33004838 | Wang T et al. (2020) | |
| c.1595dup | p.Ala533SerfsTer7 | frameshift_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.1443C>T | p.Asn481%3D | synonymous_variant | De novo | - | Simplex | 35982159 | Zhou X et al. (2022) | |
| c.46G>T | p.Asp16Tyr | missense_variant | Unknown | - | Unknown | 25363760 | De Rubeis S , et al. (2014) | |
| c.235_238del | p.Ile79PhefsTer23 | frameshift_variant | De novo | - | - | 33004838 | Wang T et al. (2020) | |
| c.342_343del | p.Gly115ArgfsTer21 | frameshift_variant | De novo | - | - | 33004838 | Wang T et al. (2020) | |
| c.830A>G | p.Lys277Arg | missense_variant | Unknown | - | Unknown | 25363760 | De Rubeis S , et al. (2014) | |
| c.964C>G | p.Leu322Val | missense_variant | Unknown | - | Unknown | 25363760 | De Rubeis S , et al. (2014) | |
| c.1351_1354del | p.Ser451ProfsTer23 | frameshift_variant | De novo | - | - | 33004838 | Wang T et al. (2020) | |
| c.2028_2029del | p.His676GlnfsTer13 | frameshift_variant | Unknown | - | - | 33004838 | Wang T et al. (2020) | |
| c.832-2A>G | - | splice_site_variant | Familial | Paternal | Multiplex | 31398340 | Ruzzo EK , et al. (2019) | |
| c.1239del | p.Asp413GlufsTer42 | frameshift_variant | De novo | - | - | 32341456 | Nakashima M et al. (2020) | |
| c.2156A>G | p.His719Arg | missense_variant | De novo | - | Simplex | 25969726 | Codina-Sol M , et al. (2015) | |
| c.398C>G | p.Ser133Ter | stop_gained | De novo | - | Simplex | 31696658 | da Silva Montenegro EM , et al. (2019) | |
| c.50T>G | p.Val17Gly | missense_variant | Familial | Paternal | Simplex | 25363760 | De Rubeis S , et al. (2014) | |
| c.392_395del | p.Gly131AspfsTer28 | frameshift_variant | Unknown | - | Simplex | 28263302 | C Yuen RK et al. (2017) | |
| c.171_179delinsCGAAG | p.Met58GlufsTer20 | frameshift_variant | De novo | - | Simplex | 28191889 | Stessman HA , et al. (2017) | |
| c.713_714insGT | p.Lys241Ter | frameshift_variant | Familial | Maternal | Multiplex | 37506195 | Cirnigliaro M et al. (2023) | |
| c.531C>A | p.Val177= | synonymous_variant | De novo | - | Unknown | 25533962 | Deciphering Developmental Disorders Study (2014) | |
| c.2004del | p.Leu669TyrfsTer33 | frameshift_variant | De novo | - | Unknown | 25533962 | Deciphering Developmental Disorders Study (2014) |
Common Variants (1)
| Status | Allele Change | Residue Change | Variant Type | Inheritance Pattern | Paternal Transmission | Family Type | PubMed ID | Author, Year |
|---|---|---|---|---|---|---|---|---|
| c.180+8949G>T;c.396+8949G>T;c.378+8949G>T;c.-186+8949G>T;c.345+8949G>T;c.232-11807G>T;c.336+8949G>T; | - | intron_variant | - | - | - | 29483656 | Pardias AF , et al. (2018) |
SFARI Gene score
1
High Confidence
Score Delta: Score remained at 1
criteria met
See SFARI Gene'scoring criteriaWe considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.
4/1/2021
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
10/1/2020
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
4/1/2020
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
10/1/2019
1
1
Score remained at 1
New Scoring Scheme
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
7/1/2019
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
Reports Added
[Autism-associated missense genetic variants impact locomotion and neurodevelopment in Caenorhabditis elegans.2019] [Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.2019] [Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.2019]4/1/2019
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
1/1/2019
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
10/1/2018
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) were reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CUL3 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016 (PMID 27824329).
4/1/2017
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016.
Reports Added
[Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.2012] [Synaptic, transcriptional and chromatin genes disrupted in autism.2014] [Rate of de novo mutations and the importance of father's age to disease risk.2012] [Large-scale discovery of novel genetic causes of developmental disorders.2014] [Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.2013] [Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.2013] [Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders.2015] [Low load for disruptive mutations in autism genes and their biased transmission.2015] [Regulation of the CUL3Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.2016] [De novo genic mutations among a Chinese autism spectrum disorder cohort.2016] [The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.2016] [Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.2017] [Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder2017]1/1/2017
1
1
Score remained at 1
Description
2 de novo LoF mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016.
10/1/2016
2
1
Decreased from 2 to 1
Description
2 de novo LoF mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A third de novo LoF variant in CUL3 was identified in a Chinese ASD proband from the Autism Clinical and Genetic Resources in China (ACGC) cohort in Wang et al., 2016.
1/1/2016
2
2
Decreased from 2 to 2
Description
2 de novo LoF mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760).
Reports Added
[Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.2012] [Synaptic, transcriptional and chromatin genes disrupted in autism.2014] [Rate of de novo mutations and the importance of father's age to disease risk.2012] [Large-scale discovery of novel genetic causes of developmental disorders.2014] [Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.2013] [Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.2013] [Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders.2015] [Low load for disruptive mutations in autism genes and their biased transmission.2015]4/1/2015
2
2
Decreased from 2 to 2
Description
2 de novo LoF mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760).
1/1/2015
2
2
Decreased from 2 to 2
Description
2 de novo LGD mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760).
10/1/2014
3
2
Decreased from 3 to 2
Description
2 de novo LGD mutations (both nonsense variants) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163). Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CUL3 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760).
7/1/2014
No data
3
Increased from No data to 3
Description
2 de novo LGD mutations (both nonsense variant) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163)
4/1/2014
No data
3
Increased from No data to 3
Description
2 de novo LGD mutations (both nonsense variant) reported in the CUL3 gene in unrelated ASD cases (PMIDs 22495309 and 22914163)
Krishnan Probability Score
Score 0.49653465388827
Ranking 2576/25841 scored genes
[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning
approach on a human brain-specific gene network. The method was first presented in Nat
Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed
in column G of supplementary table 3 (see:
http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser,
with the ability to view networks of associated ASD risk genes, can be found at
asd.princeton.edu.
ExAC Score
Score 0.97406340543885
Ranking 2274/18225 scored genes
[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has
been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by
Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at
exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of-
function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of-
function mutations in autism in such a gene would be more likely to confer risk. For a full list of
pLI scores see:
ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle
aned_exac_nonTCGA_z_pli_rec_null_data.txt
Iossifov Probability Score
Score 0.901
Ranking 138/239 scored genes
[Show Scoring Methodology]
Supplementary dataset S2 in the paper by Iossifov et al. (PNAS 112, E5600-E5607 (2015)) lists
239 genes with a probability of at least 0.8 of being associated with autism risk (column I). This
probability metric combines the evidence from de novo likely-gene- disrupting and missense
mutations and assesses it against the background mutation rate in unaffected individuals from the
University of Washingtonâs Exome Variant Sequence database (evs.gs.washington.edu/EVS/).
The list of probability scores can be found here:
www.pnas.org/lookup/suppl/doi:10.1073/pnas.1516376112/-
/DCSupplemental/pnas.1516376112.sd02.xlsx
Sanders TADA Score
Score 0.0052620906397329
Ranking 25/18665 scored genes
[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013),
and is a statistic that integrates evidence from both de novo and transmitted mutations.
It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233
(2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper
(the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Larsen Cumulative Evidence Score
Score 30
Ranking 72/461 scored genes
[Show Scoring Methodology]
Larsen and colleagues generated gene scores based on the sum of evidence for all available
ASD-associated variants in a gene, with assessments based on mode of inheritance, effect size,
and variant frequency in the general population. The approach was first presented in Mol Autism
7:44 (2016), and scores for 461 genes can be found in column I in supplementary table 4 from
that paper.
Zhang D Score
Score 0.19041145895806
Ranking 4418/20870 scored genes
[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures),
or D score, was developed to combine evidence from de novo loss-of- function mutation with
evidence from cell-type- specific gene expression in the mouse brain (specifically translational
profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with
positive D scores are more likely to be associated with autism risk, with higher-confidence genes
having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204-
215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in
supplementary table 2 from that paper.
External PIN Data
Interactome
- Protein Binding
- DNA Binding
- RNA Binding
- Protein Modification
- Direct Regulation
- ASD-Linked Genes
Interaction Table
| Interactor Symbol | Interactor Name | Interactor Organism | Interactor Type | Entrez ID | Uniprot ID |
|---|---|---|---|---|---|
| 10-Sep | septin 10 | Human | Protein Binding | 151011 | Q9P0V9 |
| 15-Sep | selenophosphate synthetase 1 | Human | Protein Binding | 22929 | B4DWK0 |
| AAR2 | AAR2 splicing factor homolog (S. cerevisiae) | Human | Protein Binding | 25980 | Q9Y312 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | Human | Protein Binding | 154664 | Q86UQ4 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | Human | Protein Binding | 80325 | Q969K4 |
| ACBD3 | acyl-CoA binding domain containing 3 | Human | Protein Binding | 64746 | Q9H3P7 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | Human | Protein Binding | 59 | D2JYH4 |
| ADD3 | adducin 3 (gamma) | Human | Protein Binding | 120 | Q9UEY8 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | Human | Protein Binding | 178 | P35573 |
| AGO1 | argonaute RISC catalytic component 1 | Human | Protein Binding | 26523 | Q9UL18 |
| AGO3 | argonaute RISC catalytic component 3 | Human | Protein Binding | 192669 | B4E1P5 |
| AHCY | adenosylhomocysteinase | Human | Protein Binding | 191 | P23526 |
| AIM1 | absent in melanoma 1 | Human | Protein Binding | 202 | B3KPT0 |
| AK2 | adenylate kinase 2 | Human | Protein Binding | 204 | P54819 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | Human | Protein Binding | 217 | P05091 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | Human | Protein Binding | 224 | P51648 |
| ALDOA | aldolase A, fructose-bisphosphate | Human | Protein Binding | 226 | P04075 |
| ALYREF | Aly/REF export factor | Human | Protein Binding | 10189 | E9PB61 |
| AMPD1 | adenosine monophosphate deaminase 1 | Human | Protein Binding | 270 | P23109 |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 | Human | Protein Binding | 51479 | Q9P2R3 |
| ANKRD26 | ankyrin repeat domain 26 | Human | DNA Binding | 22852 | Q9UPS8 |
| ANKRD39 | ankyrin repeat domain 39 | Human | Protein Binding | 51239 | Q53RE8 |
| AP1B1 | adaptor-related protein complex 1, beta 1 subunit | Human | Protein Binding | 162 | Q10567 |
| ARL1 | ADP-ribosylation factor-like 1 | Human | Protein Binding | 400 | P40616 |
| ARMC8 | armadillo repeat containing 8 | Human | Protein Binding | 25852 | B7Z637 |
| ASPH | aspartate beta-hydroxylase | Human | Protein Binding | 444 | B4E2K4 |
| ATAD3B | ATPase family, AAA domain containing 3B | Human | Protein Binding | 83858 | Q5T9A4 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | Human | Protein Binding | 477 | P50993 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | Human | Protein Binding | 480 | Q13733 |
| AURKA | aurora kinase A | Human | Protein Modification | 6790 | O14965 |
| AURKAIP1 | aurora kinase A interacting protein 1 | Human | Protein Binding | 54998 | Q9NWT8 |
| BCDIN3D | BCDIN3 domain containing | Human | Protein Binding | 144233 | Q7Z5W3 |
| Bcl11b | B cell leukemia/lymphoma 11B | Mouse | Protein Binding | 58208 | Q99PV8 |
| BCLAF1 | BCL2-associated transcription factor 1 | Human | Protein Binding | 9774 | Q9NYF8 |
| BOLA2 | bolA homolog 2 (E. coli) | Human | Protein Binding | 552900 | Q9H3K6 |
| BOLA2B | bolA homolog 2B (E. coli) | Human | Protein Binding | 654483 | Q9H3K6 |
| BOP1 | block of proliferation 1 | Human | Protein Binding | 23246 | Q14137 |
| BPLF1 | Deneddylase | HHV-4 | Protein Binding | 3783726 | P03186 |
| BTBD10 | BTB (POZ) domain containing 10 | Human | Protein Binding | 84280 | D3DQW7 |
| btbd6a | BTB (POZ) domain containing 6a | Zebrafish | Protein Binding | 100141360 | A9JRD8 |
| BTBD7 | BTB (POZ) domain containing 7 | Human | Protein Binding | 55727 | Q9P203 |
| BTBD8 | BTB (POZ) domain containing 8 | Human | Protein Binding | 284697 | Q5XKL5 |
| C11orf57 | chromosome 11 open reading frame 57 | Human | Protein Binding | 55216 | Q6ZUT1 |
| C11orf70 | chromosome 11 open reading frame 70 | Human | Protein Binding | 85016 | E9PJU1 |
| C14orf166 | chromosome 14 open reading frame 166 | Human | Protein Binding | 51637 | Q9Y224 |
| C17orf85 | chromosome 17 open reading frame 85 | Human | Protein Binding | 55421 | Q53F19 |
| C8orf33 | chromosome 8 open reading frame 33 | Human | Protein Binding | 65265 | Q9H7E9 |
| CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | Human | Protein Binding | 790 | P27708 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | Human | Protein Binding | 57118 | Q5SQQ7 |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma | Human | Protein Binding | 818 | Q13555 |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | Human | Protein Binding | 841 | Q14790 |
| CCDC110 | coiled-coil domain containing 110 | Human | Protein Binding | 256309 | Q8TBZ0 |
| CCDC39 | coiled-coil domain containing 39 | Human | Protein Binding | 339829 | Q9UFE4 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | Human | Protein Binding | 10421 | O95400 |
| CDC25A | cell division cycle 25A | Human | Protein Binding | 993 | P30304 |
| CDC34 | cell division cycle 34 | Human | Protein Binding | 997 | P49427 |
| CDC45 | cell division cycle 45 | Human | Protein Binding | 8318 | O75419 |
| CDKNeuro2aIP | CDKN2A interacting protein | Human | Protein Binding | 55602 | Q9NXV6 |
| CKAP4 | cytoskeleton-associated protein 4 | Human | Protein Binding | 10970 | Q07065 |
| CKB | creatine kinase, brain | Human | Protein Binding | 1152 | P12277 |
| CKMT1A | creatine kinase, mitochondrial 1A | Human | Protein Binding | 548596 | P12532 |
| CKMT1B | creatine kinase, mitochondrial 1B | Human | Protein Binding | 1159 | P12532 |
| CLPB | ClpB caseinolytic peptidase B homolog (E. coli) | Human | Protein Binding | 81570 | Q9H078 |
| CLTCL1 | clathrin, heavy chain-like 1 | Human | Protein Binding | 8218 | P53675 |
| CNNM4 | cyclin M4 | Human | Protein Binding | 26504 | Q6P4Q7 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | Human | Protein Binding | 150684 | Q8N668 |
| COMMD8 | COMM domain containing 8 | Human | Protein Binding | 54951 | Q9NX08 |
| COPS2 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | Human | Protein Binding | 9318 | P61201 |
| CPN2 | carboxypeptidase N, polypeptide 2 | Human | Protein Binding | 1370 | P22792 |
| CPNE7 | copine VII | Human | Protein Binding | 27132 | Q9UBL6 |
| CPOX | coproporphyrinogen oxidase | Human | Protein Binding | 1371 | P36551 |
| CSTB | cystatin B (stefin B) | Human | Protein Binding | 1476 | P04080 |
| CTPS1 | CTP synthase 1 | Human | Protein Binding | 1503 | P17812 |
| CUL4B | cullin 4B | Human | Protein Binding | 8450 | Q13620 |
| CWC15 | CWC15 spliceosome-associated protein | Human | Protein Binding | 51503 | Q9P013 |
| DARS | aspartyl-tRNA synthetase | Human | Protein Binding | 1615 | P14868 |
| DAZAP1 | DAZ associated protein 1 | Human | Protein Binding | 26528 | Q96EP5 |
| DCD | dermcidin | Human | Protein Binding | 117159 | P81605 |
| DCTN2 | dynactin 2 (p50) | Human | Protein Binding | 10540 | Q13561 |
| DCUN1D2 | DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) | Human | Protein Binding | 55208 | Q6PH85 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | Human | Protein Binding | 123879 | Q8IWE4 |
| DCUN1D5 | DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) | Human | Protein Binding | 84259 | Q9BTE7 |
| DDIT3 | DNA-damage-inducible transcript 3 | Human | Protein Binding | 1649 | P35638 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | Human | Protein Binding | 8886 | Q9NVP1 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | Human | Protein Binding | 54514 | Q9NQI0 |
| DERL2 | derlin 2 | Human | Protein Binding | 51009 | Q9GZP9 |
| DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | Human | Protein Binding | 1659 | Q14562 |
| DIS3 | DIS3 mitotic control homolog (S. cerevisiae) | Human | Protein Binding | 22894 | Q9Y2L1 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | Human | Protein Binding | 58512 | O95886 |
| Dmap1 | DNA methyltransferase 1-associated protein 1 | Mouse | Protein Binding | 66233 | B1AUK1 |
| DNAJC13 | DnaJ (Hsp40) homolog, subfamily C, member 13 | Human | Protein Binding | 23317 | O75165 |
| Dock2 | dedicator of cyto-kinesis 2 | Mouse | Protein Binding | 94176 | Q6A0A3 |
| DROSHA | drosha, ribonuclease type III | Human | Protein Binding | 29102 | E7EMP9 |
| DSP | desmoplakin | Human | Protein Binding | 1832 | P15924 |
| DUT | deoxyuridine triphosphatase | Human | Protein Binding | 1854 | P33316 |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | Human | Protein Binding | 1780 | A4D1I7 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | Human | Protein Binding | 6993 | P63172 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | Human | Protein Binding | 8798 | Q9NR20 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | Human | Protein Binding | 1917 | Q05639 |
| EFTUD2 | elongation factor Tu GTP binding domain containing 2 | Human | Protein Binding | 9343 | B3KX19 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | Human | Protein Binding | 5610 | P19525 |
| EIF2D | eukaryotic translation initiation factor 2D | Human | Protein Binding | 1939 | P41214 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | Human | Protein Binding | 8663 | Q99613 |
| EIF3CL | eukaryotic translation initiation factor 3, subunit C-like | Human | Protein Binding | 728689 | B5ME19 |
| EIF3G | eukaryotic translation initiation factor 3, subunit G | Human | Protein Binding | 8666 | O75821 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | Human | Protein Binding | 8668 | Q13347 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | Human | Protein Binding | 9775 | P38919 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | Human | Protein Modification | 1978 | Q13541 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | Human | Protein Binding | 1981 | Q04637 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | Human | Protein Binding | 56648 | Q9GZV4 |
| EIF6 | eukaryotic translation initiation factor 6 | Human | Protein Binding | 3692 | P56537 |
| ELC1 | Elongin-C | Baker's yeast | Protein Binding | 856061 | Q03071 |
| ENO2 | enolase 2 (gamma, neuronal) | Human | Protein Binding | 2026 | P09104 |
| EPPK1 | epiplakin 1 | Human | Protein Binding | 83481 | P58107 |
| ERAL1 | Era G-protein-like 1 (E. coli) | Human | Protein Binding | 26284 | O75616 |
| EXOSC10 | exosome component 10 | Human | Protein Binding | 5394 | Q01780 |
| EXOSC5 | exosome component 5 | Human | Protein Binding | 56915 | Q9NQT4 |
| EXOSC9 | exosome component 9 | Human | Protein Binding | 5393 | Q06265 |
| FAF2 | Fas associated factor family member 2 | Human | Protein Binding | 23197 | Q96CS3 |
| FAM103A1 | family with sequence similarity 103, member A1 | Human | Protein Binding | 83640 | Q9BTL3 |
| FAM120B | family with sequence similarity 120B | Human | Protein Binding | 84498 | Q96EK7 |
| FAM208B | family with sequence similarity 208, member B | Human | Protein Binding | 54906 | Q5VWN6 |
| FAM98A | family with sequence similarity 98, member A | Human | Protein Binding | 25940 | I6L9E8 |
| FANCI | Fanconi anemia, complementation group I | Human | Protein Binding | 55215 | Q9NVI1 |
| FARSA | phenylalanyl-tRNA synthetase, alpha subunit | Human | Protein Binding | 2193 | Q6IBR2 |
| FBL | fibrillarin | Human | Protein Binding | 2091 | P22087 |
| FBXO3 | F-box protein 3 | Human | Protein Binding | 26273 | Q49AF1 |
| FECH | ferrochelatase | Human | Protein Binding | 2235 | P22830 |
| FLOT2 | flotillin 2 | Human | Protein Binding | 2319 | Q14254 |
| FN3KRP | fructosamine 3 kinase related protein | Human | Protein Binding | 79672 | Q9HA64 |
| FOLR1 | folate receptor 1 (adult) | Human | Protein Binding | 2348 | P15328 |
| FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) | Human | Protein Binding | 24140 | B3KN91 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | Human | Protein Binding | 2517 | P04066 |
| FUCA2 | fucosidase, alpha-L- 2, plasma | Human | Protein Binding | 2519 | Q9BTY2 |
| FXR2 | Fragile X retardation 2 | Human | Protein Binding | 9513 | P51116 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | Human | Protein Binding | 23710 | Q9H0R8 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | Human | Protein Binding | 11345 | P60520 |
| GALK1 | galactokinase 1 | Human | Protein Binding | 2584 | P51570 |
| GAN | gigaxonin | Human | Protein Binding | 8139 | B3KTC3 |
| GCAT | glycine C-acetyltransferase | Human | Protein Binding | 23464 | O75600 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | Human | Protein Binding | 9945 | O94808 |
| GLIS3 | GLIS family zinc finger 3 | Human | Protein Binding | 169792 | Q1PHJ8 |
| GLMN | glomulin, FKBP associated protein | Human | Protein Binding | 11146 | Q92990 |
| GMPPA | GDP-mannose pyrophosphorylase A | Human | Protein Binding | 29926 | Q96IJ6 |
| GPATCH4 | G patch domain containing 4 | Human | Protein Binding | 54865 | A8KAG1 |
| GPN1 | GPN-loop GTPase 1 | Human | Protein Binding | 11321 | B5MBZ5 |
| GPS1 | G protein pathway suppressor 1 | Human | Protein Binding | 2873 | Q13098 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | Human | Protein Binding | 84706 | Q8TD30 |
| GSTP1 | glutathione S-transferase pi 1 | Human | Protein Binding | 2950 | P09211 |
| GTF3C5 | general transcription factor IIIC, polypeptide 5, 63kDa | Human | Protein Binding | 9328 | Q9Y5Q8 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | Human | Protein Binding | 387751 | Q7Z2Y8 |
| H2AFY | H2A histone family, member Y | Human | Protein Binding | 9555 | O75367 |
| HAT1 | histone acetyltransferase 1 | Human | Protein Binding | 8520 | O14929 |
| Hist1h1d | histone cluster 1, H1d | Mouse | Protein Binding | 14957 | P43277 |
| Hist1h2ae | histone cluster 1, H2ae | Mouse | Protein Binding | 319166 | B2RVF0 |
| HIST1H4D | histone cluster 1, H4d | Human | Protein Binding | 8360 | P62805 |
| HIST1H4F | histone cluster 1, H4f | Human | Protein Binding | 8361 | B2R4R0 |
| HIST1H4I | histone cluster 1, H4i | Human | Protein Binding | 8294 | B2R4R0 |
| HIST1H4L | histone cluster 1, H4l | Human | Protein Binding | 8368 | B2R4R0 |
| HIST2H4A | histone cluster 2, H4a | Human | Protein Binding | 8370 | B2R4R0 |
| HIST2H4B | histone cluster 2, H4b | Human | Protein Binding | 554313 | B2R4R0 |
| HIST4H4 | histone cluster 4, H4 | Human | Protein Binding | 121504 | B2R4R0 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | Human | Protein Binding | 3109 | P28068 |
| HLA-H | major histocompatibility complex, class I, H (pseudogene) | Human | Protein Binding | 3136 | P01893 |
| HMGB3P1 | high mobility group box 3 pseudogene 1 | Human | Protein Binding | 128872 | N/A |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | Human | Protein Binding | 3182 | Q99729 |
| HNRNPCL1 | heterogeneous nuclear ribonucleoprotein C-like 1 | Human | Protein Binding | 343069 | O60812 |
| HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 (H') | Human | Protein Binding | 3188 | P55795 |
| HOOK3 | hook homolog 3 (Drosophila) | Human | Protein Binding | 84376 | Q86VS8 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | Human | Protein Binding | 3251 | P00492 |
| Hrh4 | histamine receptor H4 | Mouse | Protein Binding | 225192 | Q91ZY2 |
| HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 | Human | Protein Binding | 3028 | Q99714 |
| HSP90AA2 | heat shock protein 90kDa alpha (cytosolic), class A member 2 | Human | Protein Binding | 3324 | Q14568 |
| HSP90AB2P | heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene | Human | Protein Binding | 391634 | Q58FF8 |
| HSP90AB3P | heat shock protein 90kDa alpha family class B member 3, pseudogene | Human | Protein Binding | 3327 | Q58FF7 |
| HSPA1L | heat shock 70kDa protein 1-like | Human | Protein Binding | 3305 | P34931 |
| HSPB1 | heat shock 27kDa protein 1 | Human | Protein Binding | 3315 | P04792 |
| HTATSF1 | HIV-1 Tat specific factor 1 | Human | Protein Binding | 27336 | O43719 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | Human | Protein Binding | 10075 | Q7Z6Z7 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | Human | DNA Binding | 3454 | P17181 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | Human | Protein Binding | 10644 | Q9Y6M1 |
| ILK | integrin-linked kinase | Human | Protein Binding | 3611 | Q13418 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Human | Protein Binding | 3615 | P12268 |
| inc | Fruit Fly | Protein Binding | 31110 | Q9W579 | |
| IPO5 | importin 5 | Human | Protein Binding | 3843 | B3KWG6 |
| IPO8 | importin 8 | Human | Protein Binding | 10526 | O15397 |
| IPP | intracisternal A particle-promoted polypeptide | Human | Protein Binding | 3652 | A2A6V3 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | Human | Protein Binding | 3654 | P51617 |
| IRS4 | insulin receptor substrate 4 | Human | Protein Binding | 8471 | O14654 |
| KAT5 | K(lysine) acetyltransferase 5 | Human | Protein Binding | 10524 | Q92993 |
| KBTBD13 | kelch repeat and BTB (POZ) domain containing 13 | Human | Protein Modification | 390594 | C9JR72 |
| KBTBD6 | kelch repeat and BTB (POZ) domain containing 6 | Human | Protein Binding | 89890 | Q86V97 |
| KBTBD7 | kelch repeat and BTB (POZ) domain containing 7 | Human | Protein Binding | 84078 | Q8WVZ9 |
| KCTD10 | potassium channel tetramerisation domain containing 10 | Human | Protein Binding | 83892 | Q9H3F6 |
| KCTD11 | potassium channel tetramerisation domain containing 11 | Human | Protein Binding | 147040 | Q693B1 |
| KCTD12 | potassium channel tetramerisation domain containing 12 | Human | Protein Binding | 115207 | Q96CX2 |
| KCTD13 | potassium channel tetramerisation domain containing 13 | Human | Protein Binding | 253980 | Q8WZ19 |
| KCTD18 | potassium channel tetramerisation domain containing 18 | Human | Protein Binding | 130535 | Q6PI47 |
| KCTD2 | potassium channel tetramerisation domain containing 2 | Human | Protein Binding | 23510 | Q14681 |
| KCTD21 | potassium channel tetramerisation domain containing 21 | Human | Protein Binding | 283219 | Q4G0X4 |
| KCTD6 | potassium channel tetramerisation domain containing 6 | Human | Protein Binding | 200845 | Q8NC69 |
| KCTD7 | potassium channel tetramerisation domain containing 7 | Human | Protein Binding | 154881 | Q96MP8 |
| KCTD9 | potassium channel tetramerisation domain containing 9 | Human | Protein Binding | 54793 | Q7L273 |
| KEL | Kell blood group, metallo-endopeptidase | Human | Protein Binding | 3792 | P23276 |
| KHSRP | KH-type splicing regulatory protein | Human | Protein Binding | 8570 | Q92945 |
| KIAA1967 | KIAA1967 | Human | Protein Binding | 57805 | Q8N163 |
| KIF13B | kinesin family member 13B | Human | Protein Binding | 23303 | F8VPJ2 |
| KLHDC5 | kelch-like family member 42 | Human | Protein Binding | 57542 | B2RNT7 |
| KLHL10 | Kelch-like protein 10 | Human | Protein Binding | 317719 | Q6JEL2 |
| KLHL11 | kelch-like family member 11 | Human | Protein Binding | 55175 | Q9NVR0 |
| KLHL12 | kelch-like family member 12 | Human | Protein Binding | 59349 | Q53G59 |
| KLHL13 | kelch-like family member 13 | Human | Protein Binding | 90293 | Q96HC9 |
| KLHL17 | kelch-like family member 17 | Human | Protein Binding | 339451 | Q6TDP4 |
| KLHL2 | kelch-like family member 2 | Human | Protein Binding | 11275 | O95198 |
| KLHL25 | kelch-like family member 25 | Human | Protein Binding | 64410 | Q9H0H3 |
| KLHL26 | kelch-like family member 26 | Human | Protein Binding | 55295 | Q53HC5 |
| KLHL3 | kelch-like family member 3 | Human | Protein Binding | 26249 | Q9UH77 |
| KLHL36 | kelch-like family member 36 | Human | Protein Binding | 79786 | Q8N4N3 |
| KLHL4 | kelch-like family member 4 | Human | Protein Binding | 56062 | A5PKX1 |
| KLHL41 | kelch-like family member 41 | Human | Protein Binding | 10324 | O60662 |
| KLHL5 | kelch-like family member 5 | Human | Protein Binding | 51088 | G3XA92 |
| KLHL7 | kelch-like family member 7 | Human | Protein Binding | 55975 | A8K364 |
| KNDC1 | kinase non-catalytic C-lobe domain (KIND) containing 1 | Human | Protein Binding | 85442 | Q5U5J6 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | Human | Protein Binding | 3838 | P52292 |
| KPNA3 | karyopherin alpha 3 (importin alpha 4) | Human | Protein Binding | 3839 | O00505 |
| KRT16 | keratin 16 | Human | Protein Binding | 3868 | P08779 |
| KRT24 | keratin 24 | Human | Protein Binding | 192666 | Q2M2I5 |
| KRT33B | keratin 33B | Human | Protein Binding | 3884 | Q14525 |
| KRT36 | keratin 36 | Human | Protein Binding | 8689 | O76013 |
| KRT4 | keratin 4 | Human | Protein Binding | 3851 | B4DRS2 |
| KRT6B | keratin 6B | Human | Protein Binding | 3854 | P04259 |
| KRT71 | keratin 71 | Human | Protein Binding | 112802 | Q3SY84 |
| KRT75 | keratin 75 | Human | Protein Binding | 9119 | O95678 |
| KRT76 | keratin 76 | Human | Protein Binding | 51350 | Q01546 |
| KRT84 | keratin 84 | Human | Protein Binding | 3890 | Q9NSB2 |
| KRT85 | keratin 85 | Human | Protein Binding | 3891 | P78386 |
| LARP1 | La ribonucleoprotein domain family, member 1 | Human | Protein Binding | 23367 | Q6PKG0 |
| LARP1B | La ribonucleoprotein domain family, member 1B | Human | Protein Binding | 55132 | Q659C4 |
| LARP4 | La ribonucleoprotein domain family, member 4 | Human | Protein Binding | 113251 | Q6P4E2 |
| LARP4B | La ribonucleoprotein domain family, member 4B | Human | Protein Binding | 23185 | Q92615 |
| LARS | leucyl-tRNA synthetase | Human | Protein Binding | 51520 | Q9P2J5 |
| LDHD | lactate dehydrogenase D | Human | Protein Binding | 197257 | Q86WU2 |
| LEPRE1 | leucine proline-enriched proteoglycan (leprecan) 1 | Human | Protein Binding | 64175 | Q32P28 |
| LLGL1 | lethal giant larvae homolog 1 (Drosophila) | Human | Protein Binding | 3996 | Q15334 |
| LOC646057 | Human | Protein Binding | 646057 | N/A | |
| LOC646377 | Human | Protein Binding | 646377 | N/A | |
| LOC647013 | Human | Protein Binding | 647013 | N/A | |
| LPL | lipoprotein lipase | Human | Protein Binding | 4023 | P06858 |
| LRRC42 | leucine rich repeat containing 42 | Human | Protein Binding | 115353 | Q9Y546 |
| LSM12 | LSM12 homolog (S. cerevisiae) | Human | Protein Binding | 124801 | Q3MHD2 |
| LYAR | Ly1 antibody reactive | Human | Protein Binding | 55646 | Q9NX58 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | Human | Protein Binding | 4085 | Q13257 |
| MAGED2 | melanoma antigen family D, 2 | Human | Protein Binding | 10916 | Q9UNF1 |
| MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | Human | Protein Binding | 84557 | Q9H492 |
| MAP1LC3C | microtubule-associated protein 1 light chain 3 gamma | Human | Protein Binding | 440738 | Q9BXW4 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | Human | Protein Binding | 9261 | P49137 |
| MCM3 | minichromosome maintenance complex component 3 | Human | Protein Binding | 4172 | P25205 |
| MCM6 | minichromosome maintenance complex component 6 | Human | Protein Binding | 4175 | Q14566 |
| MCMBP | minichromosome maintenance complex binding protein | Human | Protein Binding | 79892 | Q9BTE3 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | Human | Protein Binding | 4199 | P48163 |
| METTL15 | methyltransferase like 15 | Human | Protein Binding | 76894 | Q9DCL4 |
| MIPEP | mitochondrial intermediate peptidase | Human | Protein Binding | 4285 | Q99797 |
| MMS19 | MMS19 nucleotide excision repair homolog (S. cerevisiae) | Human | Protein Binding | 64210 | Q96T76 |
| MRPL14 | mitochondrial ribosomal protein L14 | Human | Protein Binding | 64928 | Q6P1L8 |
| MRPL21 | mitochondrial ribosomal protein L21 | Human | Protein Binding | 219927 | Q7Z2W9 |
| MRPL24 | mitochondrial ribosomal protein L24 | Human | Protein Binding | 79590 | Q96A35 |
| MRPL28 | mitochondrial ribosomal protein L28 | Human | Protein Binding | 10573 | Q13084 |
| MRPL37 | mitochondrial ribosomal protein L37 | Human | Protein Binding | 51253 | Q9BZE1 |
| MRPL4 | mitochondrial ribosomal protein L4 | Human | Protein Binding | 51073 | Q9BYD3 |
| MRPL45 | mitochondrial ribosomal protein L45 | Human | Protein Binding | 84311 | Q9BRJ2 |
| MRPL49 | mitochondrial ribosomal protein L49 | Human | Protein Binding | 740 | Q13405 |
| MRPS11 | mitochondrial ribosomal protein S11 | Human | Protein Binding | 64963 | P82912 |
| MRPS15 | mitochondrial ribosomal protein S15 | Human | Protein Binding | 64960 | P82914 |
| MRPS21 | mitochondrial ribosomal protein S21 | Human | Protein Binding | 54460 | P82921 |
| MRPS23 | mitochondrial ribosomal protein S23 | Human | Protein Binding | 51649 | Q9Y3D9 |
| MRPS26 | mitochondrial ribosomal protein S26 | Human | Protein Binding | 64949 | Q9BYN8 |
| MRPS27 | mitochondrial ribosomal protein S27 | Human | Protein Binding | 23107 | Q92552 |
| MRPS31 | mitochondrial ribosomal protein S31 | Human | Protein Binding | 10240 | Q92665 |
| MRPS34 | mitochondrial ribosomal protein S34 | Human | Protein Binding | 65993 | P82930 |
| MRPS9 | mitochondrial ribosomal protein S9 | Human | Protein Binding | 64965 | P82933 |
| MSH6 | mutS homolog 6 (E. coli) | Human | Protein Binding | 2956 | P52701 |
| MTFR2 | mitochondrial fission regulator 2 | Human | Protein Binding | 71804 | Q8VED8 |
| MTMR3 | myotubularin related protein 3 | Human | Protein Binding | 8897 | Q13615 |
| MYBBP1A | MYB binding protein (P160) 1a | Human | Protein Binding | 10514 | Q9BQG0 |
| MYEOV2 | myeloma overexpressed 2 | Human | Protein Binding | 150678 | Q8WXC6 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | Human | Protein Binding | 254827 | Q58DX5 |
| Nacc1 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | Mouse | Protein Binding | 66830 | Q7TSZ8 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | Human | Protein Binding | 4673 | P55209 |
| NCBP1 | nuclear cap binding protein subunit 1, 80kDa | Human | Protein Binding | 4686 | Q09161 |
| NDUFA4P1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, pseudogene 1 | Human | Protein Binding | 360165 | N/A |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | Human | Protein Binding | 4738 | Q15843 |
| NISCH | nischarin | Human | Protein Binding | 11188 | Q9Y2I1 |
| NKRF | NFKB repressing factor | Human | Protein Binding | 55922 | G3V1N1 |
| NLE1 | notchless homolog 1 (Drosophila) | Human | Protein Binding | 54475 | Q9NVX2 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | Human | Protein Binding | 55968 | Q53FE8 |
| NSUN2 | NOP2/Sun RNA methyltransferase family, member 2 | Human | Protein Binding | 54888 | Q08J23 |
| NTPCR | nucleoside-triphosphatase, cancer-related | Human | Protein Binding | 84284 | Q5TDE9 |
| NUDCD3 | NudC domain containing 3 | Human | Protein Binding | 23386 | Q8IVD9 |
| NUDT16L1 | nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 | Human | Protein Binding | 84309 | B2RD96 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | Human | Protein Binding | 11051 | O43809 |
| NUP107 | nucleoporin 107kDa | Human | Protein Binding | 57122 | P57740 |
| NUP160 | nucleoporin 160kDa | Human | Protein Binding | 23279 | Q12769 |
| NUP88 | nucleoporin 88kDa | Human | Protein Binding | 4927 | Q99567 |
| NYAP1 | neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 | Human | Protein Binding | 222950 | Q6ZVC0 |
| OFCC1 | orofacial cleft 1 candidate 1 | Human | Protein Binding | 266553 | Q8IZS5 |
| OR2T35 | olfactory receptor, family 2, subfamily T, member 35 | Human | Protein Binding | 403244 | Q8NGX2 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | Human | Protein Binding | 5033 | P13674 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | Human | Protein Binding | 5034 | P07237 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | Human | Protein Binding | 8761 | Q13310 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | Human | Protein Binding | 10606 | P22234 |
| PBDC1 | polysaccharide biosynthesis domain containing 1 | Human | Protein Binding | 51260 | Q9BVG4 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | Human | Protein Binding | 5092 | P61457 |
| PCDHA6 | protocadherin alpha 6 | Human | Protein Binding | 56142 | Q9UN73 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | Human | Protein Binding | 5110 | H7BY58 |
| PDHA2 | pyruvate dehydrogenase (lipoamide) alpha 2 | Human | Protein Binding | 5161 | P29803 |
| PDPR | pyruvate dehydrogenase phosphatase regulatory subunit | Human | Protein Binding | 55066 | Q8NCN5 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | Human | Protein Binding | 8566 | O00764 |
| PEF1 | penta-EF-hand domain containing 1 | Human | Protein Binding | 553115 | Q9UBV8 |
| PELO | pelota homolog (Drosophila) | Human | Protein Binding | 53918 | Q9BRX2 |
| PFKP | phosphofructokinase, platelet | Human | Protein Binding | 5214 | B3KS15 |
| PGAM5 | phosphoglycerate mutase family member 5 | Human | Protein Binding | 192111 | Q96HS1 |
| PGM3 | phosphoglucomutase 3 | Human | Protein Binding | 5238 | B4DX94 |
| PHAX | phosphorylated adaptor for RNA export | Human | Protein Binding | 51808 | Q9H814 |
| PHF6 | PHD finger protein 6 | Human | Protein Binding | 84295 | Q8IWS0 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | Human | Protein Binding | 5351 | Q02809 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | Human | Protein Binding | 8985 | O60568 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | Human | Protein Binding | 26073 | Q9Y2S7 |
| POLR2E | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa | Human | Protein Binding | 5434 | P19388 |
| POLRMT | polymerase (RNA) mitochondrial (DNA directed) | Human | Protein Binding | 5442 | O00411 |
| POP1 | processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) | Human | Protein Binding | 10940 | Q99575 |
| PPIH | peptidylprolyl isomerase H (cyclophilin H) | Human | Protein Binding | 10465 | O43447 |
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | Human | Protein Binding | 5499 | P62136 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | Human | Protein Binding | 23645 | O75807 |
| PPP4C | protein phosphatase 4, catalytic subunit | Human | Protein Binding | 5531 | P60510 |
| PRDX3 | peroxiredoxin 3 | Human | Protein Binding | 10935 | P30048 |
| PRDX4 | peroxiredoxin 4 | Human | Protein Binding | 10549 | Q13162 |
| PRMT1 | protein arginine methyltransferase 1 | Human | Protein Binding | 3276 | B4E3C3 |
| PRPF19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) | Human | Protein Binding | 27339 | Q9UMS4 |
| PRPF31 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | Human | Protein Binding | 26121 | F1T0A5 |
| PRPF4 | PRP4 pre-mRNA processing factor 4 homolog (yeast) | Human | Protein Binding | 9128 | O43172 |
| PRPF8 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) | Human | Protein Binding | 10594 | Q6P2Q9 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | Human | Protein Binding | 5700 | P62191 |
| PTPRT | protein tyrosine phosphatase, receptor type, T | Human | Protein Binding | 11122 | O14522 |
| PUF60 | poly-U binding splicing factor 60KDa | Human | Protein Binding | 22827 | Q9UHX1 |
| PURA | purine-rich element binding protein A | Human | Protein Binding | 5813 | Q00577 |
| PWP2 | PWP2 periodic tryptophan protein homolog (yeast) | Human | Protein Binding | 5822 | Q15269 |
| PXDNL | peroxidasin homolog (Drosophila)-like | Human | Protein Binding | 137902 | A1KZ92 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | Human | Protein Binding | 5831 | P32322 |
| PYCR2 | pyrroline-5-carboxylate reductase family, member 2 | Human | Protein Binding | 29920 | Q96C36 |
| PYCRL | pyrroline-5-carboxylate reductase-like | Human | Protein Binding | 65263 | Q53H96 |
| QDPR | quinoid dihydropteridine reductase | Human | Protein Binding | 5860 | P09417 |
| QPCT | glutaminyl-peptide cyclotransferase | Human | Protein Binding | 25797 | Q16769 |
| RAE1 | RAE1 RNA export 1 homolog (S. pombe) | Human | Protein Binding | 8480 | P78406 |
| RARS | arginyl-tRNA synthetase | Human | Protein Binding | 5917 | P54136 |
| RBM10 | RNA binding motif protein 10 | Human | Protein Binding | 8241 | P98175 |
| RBM14 | RNA binding motif protein 14 | Human | Protein Binding | 10432 | Q96PK6 |
| RBM28 | RNA binding motif protein 28 | Human | Protein Binding | 55131 | B4DU52 |
| RBM45 | RNA binding motif protein 45 | Human | Protein Binding | 129831 | Q8IUH3 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | Human | Protein Binding | 27288 | O75526 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | Human | Protein Binding | 55213 | B3KR20 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | Human | Protein Binding | 5982 | P35250 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | Human | Protein Binding | 5985 | F8W9B4 |
| RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1 | Human | Protein Binding | 83695 | Q9BSD3 |
| RHOBTB2 | Rho-related BTB domain containing 2 | Human | Protein Binding | 23221 | A8K9Z8 |
| RHOBTB3 | Rho-related BTB domain containing 3 | Human | Protein Binding | 22836 | O94955 |
| RNMT | RNA (guanine-7-) methyltransferase | Human | Protein Binding | 8731 | O43148 |
| RNPS1 | RNA binding protein S1, serine-rich domain | Human | Protein Binding | 10921 | D3DU92 |
| Rorc | RAR-related orphan receptor gamma | Mouse | Protein Binding | 19885 | P51450 |
| RPL10A | ribosomal protein L10a | Human | Protein Binding | 4736 | P62906 |
| RPL10P16 | ribosomal protein L10 pseudogene 16 | Human | Protein Binding | 284393 | N/A |
| RPL13P12 | ribosomal protein L13 pseudogene 12 | Human | Protein Binding | 388344 | N/A |
| RPL21P16 | ribosomal protein L21 pseudogene 16 | Human | Protein Binding | 729402 | N/A |
| RPL21P19 | ribosomal protein L21 pseudogene 19 | Human | Protein Binding | 641293 | N/A |
| RPL26L1 | ribosomal protein L26-like 1 | Human | Protein Binding | 51121 | Q9UNX3 |
| RPL31 | ribosomal protein L31 | Human | Protein Binding | 6160 | P62899 |
| RPL36AP37 | ribosomal protein L36a pseudogene 37 | Human | Protein Binding | 729362 | N/A |
| RPL5 | ribosomal protein L5 | Human | Protein Binding | 6125 | A2RUM7 |
| RPL7A | ribosomal protein L7a | Human | Protein Binding | 6130 | P62424 |
| RPL7AP27 | ribosomal protein L7a pseudogene 27 | Human | Protein Binding | 152663 | N/A |
| RPL8 | ribosomal protein L8 | Human | Protein Binding | 6132 | P62917 |
| RPL9 | ribosomal protein L9 | Human | Protein Binding | 6133 | P32969 |
| RPP25L | ribonuclease P/MRP 25kDa subunit-like | Human | Protein Binding | 138716 | Q8N5L8 |
| RPP30 | ribonuclease P/MRP 30kDa subunit | Human | Protein Binding | 10556 | P78346 |
| RPS10 | ribosomal protein S10 | Human | Protein Binding | 6204 | P46783 |
| RPS16 | ribosomal protein S16 | Human | Protein Binding | 6217 | P62249 |
| RPS17 | ribosomal protein S17 | Human | Protein Binding | 6218 | P08708 |
| RPS2 | ribosomal protein S2 | Human | Protein Binding | 6187 | P15880 |
| RPS20 | ribosomal protein S20 | Human | Protein Binding | 6224 | P60866 |
| RPS26P54 | ribosomal protein S26 pseudogene 54 | Human | Protein Binding | 100131971 | N/A |
| RPS28 | ribosomal protein S28 | Human | Protein Binding | 6234 | B2R4R9 |
| RPS7 | ribosomal protein S7 | Human | Protein Binding | 6201 | P62081 |
| RPS7P4 | ribosomal protein S7 pseudogene 4 | Human | Protein Binding | 149224 | N/A |
| RPS8 | ribosomal protein S8 | Human | Protein Binding | 6202 | P62241 |
| RPSAP12 | ribosomal protein SA pseudogene 12 | Human | Protein Binding | 387867 | N/A |
| RPSAP15 | ribosomal protein SA pseudogene 15 | Human | Protein Binding | 220885 | N/A |
| RPSAP55 | ribosomal protein SA pseudogene 55 | Human | Protein Binding | 388122 | N/A |
| RRBP1 | ribosome binding protein 1 | Human | Protein Binding | 6238 | Q9P2E9 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | Human | Protein Binding | 23223 | B3KMR5 |
| RRP15 | ribosomal RNA processing 15 homolog (S. cerevisiae) | Human | Protein Binding | 51018 | Q9Y3B9 |
| SAMHD1 | SAM domain and HD domain 1 | Human | Protein Binding | 25939 | Q59H15 |
| SART1 | squamous cell carcinoma antigen recognized by T cells | Human | Protein Binding | 9092 | O43290 |
| SCO2 | SCO cytochrome oxidase deficient homolog 2 (yeast) | Human | Protein Binding | 9997 | O43819 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | Human | Protein Binding | 23753 | Q9HCN8 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | Human | Protein Binding | 6390 | P21912 |
| SEC13 | SEC13 homolog (S. cerevisiae) | Human | Protein Binding | 6396 | A8MV37 |
| SEC24C | SEC24 family, member C (S. cerevisiae) | Human | Protein Binding | 9632 | P53992 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | Human | Protein Binding | 10291 | E9PAW1 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | Human | Protein Binding | 23451 | A0JLT9 |
| SF3B3 | splicing factor 3b, subunit 3, 130kDa | Human | Protein Binding | 23450 | A8K6V3 |
| SHKBP1 | SH3KBP1 binding protein 1 | Human | Protein Binding | 92799 | Q8TBC3 |
| SLC16A1 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) | Human | Protein Binding | 6566 | P53985 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | Human | Protein Binding | 6507 | P43003 |
| SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | Human | Protein Binding | 79751 | Q9H936 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | Human | Protein Binding | 79085 | Q9BV35 |
| SLC3A2 | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | Human | Protein Binding | 6520 | J3KPF3 |
| SMC1A | structural maintenance of chromosomes 1A | Human | Protein Binding | 8243 | Q14683 |
| SMN1 | survival of motor neuron 1, telomeric | Human | Protein Binding | 6606 | Q16637 |
| SMN2 | survival of motor neuron 2, centromeric | Human | Protein Binding | 6607 | Q16637 |
| SMNDC1 | survival motor neuron domain containing 1 | Human | Protein Binding | 10285 | O75940 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | Human | Protein Binding | 6626 | P09012 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | Human | Protein Binding | 6629 | P08579 |
| SNRPD2 | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa | Human | Protein Binding | 6633 | P62316 |
| SNW1 | SNW domain containing 1 | Human | Protein Binding | 22938 | Q13573 |
| SRPK1 | SRSF protein kinase 1 | Human | Protein Binding | 6732 | B4DS61 |
| SRSF11 | serine/arginine-rich splicing factor 11 | Human | Protein Binding | 9295 | Q05519 |
| SRSF5 | serine/arginine-rich splicing factor 5 | Human | Protein Binding | 6430 | Q13243 |
| SSR1 | signal sequence receptor, alpha | Human | Protein Binding | 6745 | P43307 |
| Stat1 | signal transducer and activator of transcription 1 | Mouse | Protein Binding | 20846 | P42225 |
| STRBP | spermatid perinuclear RNA binding protein | Human | Protein Binding | 55342 | Q96SI9 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | Human | Protein Binding | 8801 | Q3ZCW5 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | Human | Protein Binding | 11198 | Q9Y5B9 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | Human | Protein Binding | 6829 | O00267 |
| TAF5 | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa | Human | Protein Binding | 6877 | Q15542 |
| TBL2 | transducin (beta)-like 2 | Human | Protein Binding | 26608 | Q9Y4P3 |
| TECR | trans-2,3-enoyl-CoA reductase | Human | Protein Binding | 9524 | Q9NZ01 |
| TEFM | transcription elongation factor, mitochondrial | Human | Protein Binding | 79736 | Q96QE5 |
| TFAM | transcription factor A, mitochondrial | Human | Protein Binding | 7019 | A8MRB2 |
| TFB2M | transcription factor B2, mitochondrial | Human | Protein Binding | 64216 | Q9H5Q4 |
| TFG | TRK-fused gene | Human | Protein Binding | 10342 | Q92734 |
| tim | timeless | Fruit Fly | Protein Binding | 33571 | P49021 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | Human | Protein Binding | 26517 | Q9Y5L4 |
| TIPRL | TIP41, TOR signaling pathway regulator-like (S. cerevisiae) | Human | Protein Binding | 261726 | O75663 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | Human | Protein Binding | 160335 | Q8N394 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | Human | Protein Binding | 8797 | O00220 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | Human | Protein Binding | 8795 | O14763 |
| TNRC6C | trinucleotide repeat containing 6C | Human | Protein Binding | 57690 | G3XAB8 |
| TOE1 | target of EGR1, member 1 (nuclear) | Human | Protein Binding | 114034 | Q96GM8 |
| TPM3 | tropomyosin 3 | Human | Protein Binding | 7170 | P06753 |
| TRAP1 | TNF receptor-associated protein 1 | Human | Protein Binding | 10131 | Q12931 |
| TRIM28 | tripartite motif containing 28 | Human | Protein Binding | 10155 | Q13263 |
| TRMT10C | tRNA methyltransferase 10 homolog C (S. cerevisiae) | Human | Protein Binding | 54931 | Q7L0Y3 |
| TRMT6 | tRNA methyltransferase 6 homolog (S. cerevisiae) | Human | Protein Binding | 51605 | Q9UJA5 |
| TTC37 | tetratricopeptide repeat domain 37 | Human | Protein Binding | 9652 | Q6PGP7 |
| TTC7B | tetratricopeptide repeat domain 7B | Human | Protein Binding | 145567 | Q6PIF1 |
| TUBA1C | tubulin, alpha 1c | Human | Protein Binding | 84790 | Q9BQE3 |
| TUBA3C | tubulin, alpha 3c | Human | Protein Binding | 7278 | Q13748 |
| TUBA3D | tubulin, alpha 3d | Human | Protein Binding | 113457 | Q13748 |
| TUBA4A | tubulin, alpha 4a | Human | Protein Binding | 7277 | P68366 |
| TUBA4B | tubulin, alpha 4b (pseudogene) | Human | Protein Binding | 80086 | Q9H853 |
| TUBB1 | tubulin, beta 1 class VI | Human | Protein Binding | 81027 | Q9H4B7 |
| TUBB4A | tubulin, beta 4A class IVa | Human | Protein Binding | 10382 | P04350 |
| TUBB4B | tubulin, beta 4B class IVb | Human | Protein Binding | 10383 | P68371 |
| TUBB6 | tubulin, beta 6 class V | Human | Protein Binding | 84617 | Q9BUF5 |
| TXNDC5 | thioredoxin domain containing 5 (endoplasmic reticulum) | Human | Protein Binding | 81567 | Q6EHZ3 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | Human | Protein Binding | 7317 | P22314 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | Human | Protein Binding | 7325 | Q96LR5 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | Human | Protein Binding | 51366 | O95071 |
| UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1 | Human | Protein Binding | 56886 | Q9NYU2 |
| UMPS | uridine monophosphate synthetase | Human | Protein Binding | 7372 | A8K5J1 |
| UPF1 | UPF1 regulator of nonsense transcripts homolog (yeast) | Human | Protein Binding | 5976 | Q92900 |
| UST | uronyl-2-sulfotransferase | Human | Protein Binding | 10090 | Q9Y2C2 |
| VIM | vimentin | Human | Protein Binding | 7431 | P08670 |
| VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Human | Protein Binding | 63894 | Q6IA61 |
| WBSCR22 | Williams Beuren syndrome chromosome region 22 | Human | Protein Binding | 114049 | C9K060 |
| WDR18 | WD repeat domain 18 | Human | Protein Binding | 57418 | Q9BV38 |
| WDR6 | WD repeat domain 6 | Human | Protein Binding | 11180 | Q9NNW5 |
| WDR77 | WD repeat domain 77 | Human | Protein Binding | 79084 | Q9BQA1 |
| WNK4 | WNK lysine deficient protein kinase 4 | Human | Protein Binding | 65266 | B0LPI0 |
| XPNPEP3 | X-prolyl aminopeptidase (aminopeptidase P) 3, putative | Human | Protein Binding | 63929 | Q9NQH7 |
| YAE1D1 | Yae1 domain containing 1 | Human | Protein Binding | 57002 | B2RC46 |
| YBX3 | cold shock domain protein A | Human | Protein Binding | 8531 | P16989 |
| YLPM1 | YLP motif containing 1 | Human | Protein Binding | 56252 | P49750 |
| YTHDC2 | YTH domain containing 2 | Human | Protein Binding | 64848 | Q9H6S0 |
| ZC3H18 | zinc finger CCCH-type containing 18 | Human | Protein Binding | 124245 | Q86VM9 |
| ZMAT4 | zinc finger, matrin-type 4 | Human | Protein Binding | 79698 | Q9H898 |
| ZNF444 | zinc finger protein 444 | Human | Protein Binding | 55311 | Q8N0Y2 |