DYDC2DPY30 domain containing 2
Autism Reports / Total Reports
1 / 1Rare Variants / Common Variants
3 / 0Aliases
-Associated Syndromes
-Chromosome Band
10q23.1Associated Disorders
-Relevance to Autism
A recurrent bigenic duplication involving the DYDC1 and DYDC2 genes was identified in seven unrelated ASD cases but not in 580 controls (Girirajan et al., 2013).
Molecular Function
This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand (DYDC1).
External Links
SFARI Genomic Platforms
Reports related to DYDC2 (1 Reports)
# | Type | Title | Author, Year | Autism Report | Associated Disorders |
---|---|---|---|---|---|
1 | Primary | Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder | Girirajan S , et al. (2013) | Yes | - |
Rare Variants (3)
Status | Allele Change | Residue Change | Variant Type | Inheritance Pattern | Parental Transmission | Family Type | PubMed ID | Author, Year |
---|---|---|---|---|---|---|---|---|
- | - | copy_number_gain | Familial | Maternal | Simplex | 23375656 | Girirajan S , et al. (2013) | |
- | - | copy_number_gain | Familial | Paternal | Simplex | 23375656 | Girirajan S , et al. (2013) | |
- | - | copy_number_gain | Familial | Maternal | Multiplex | 23375656 | Girirajan S , et al. (2013) |
Common Variants
No common variants reported.
SFARI Gene score
Strong Candidate
A recurrent bigenic duplication involving the DYDC1 and DYDC2 genes was identified in seven unrelated ASD cases but not in 580 controls (Girirajan et al., 2013).
Score Delta: Score remained at 2
criteria met
See SFARI Gene'scoring criteriaWe considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.
4/1/2022
Decreased from 3 to 2
Description
A recurrent bigenic duplication involving the DYDC1 and DYDC2 genes was identified in seven unrelated ASD cases but not in 580 controls (Girirajan et al., 2013).
10/1/2019
Decreased from 4 to 3
New Scoring Scheme
Description
A recurrent bigenic duplication involving the DYDC1 and DYDC2 genes was identified in seven unrelated ASD cases but not in 580 controls (Girirajan et al., 2013).
Reports Added
[New Scoring Scheme]7/1/2015
Increased from to 4
Description
A recurrent bigenic duplication involving the DYDC1 and DYDC2 genes was identified in seven unrelated ASD cases but not in 580 controls (Girirajan et al., 2013).
Krishnan Probability Score
Score 0.49147061793924
Ranking 5523/25841 scored genes
[Show Scoring Methodology]
ExAC Score
Score 0.023312239924047
Ranking 9261/18225 scored genes
[Show Scoring Methodology]
Sanders TADA Score
Score 0.73255856119034
Ranking 1395/18665 scored genes
[Show Scoring Methodology]
Zhang D Score
Score -0.58507289473539
Ranking 19817/20870 scored genes
[Show Scoring Methodology]