Human Gene Module / Chromosome 7 / FOXP2

FOXP2forkhead box P2

Score
3
Suggestive Evidence Criteria 3.1
Autism Reports / Total Reports
11 / 34
Rare Variants / Common Variants
70 / 5
Aliases
FOXP2, SPCH1,  CAGH44,  TNRC10,  DKFZp686H1726
Associated Syndromes
-
Genetic Category
Rare Single Gene Mutation, Genetic Association
Chromosome Band
7q31.1
Associated Disorders
Severity of social reciprocity deficits (ADI-R, SC, ADHD, ASD (2 cases), autistic feature (1 case)
Relevance to Autism

Studies have found genetic association and rare variants in the FOXP2 gene that are identified with autism. Positive associations have been found in the Chinese Han population and mutations were identified in the Japanese population. However, several other studies have either found no genetic association or no rare genetic variation in the FOXP2 gene identified with autism. Separately, rare variations in the FMR1 gene have been identified with verbal dyspraxia.

Molecular Function

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes.

Reports related to FOXP2 (34 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Support A forkhead-domain gene is mutated in a severe speech and language disorder. Lai CS , et al. (2001) No -
2 Negative Association FOXP2 is not a major susceptibility gene for autism or specific language impairment. Newbury DF , et al. (2002) Yes -
3 Negative Association Evaluation of FOXP2 as an autism susceptibility gene. Wassink TH , et al. (2002) Yes -
4 Highly Cited Molecular evolution of FOXP2, a gene involved in speech and language. Enard W , et al. (2002) No -
5 Negative Association Mutation screening of FOXP2 in individuals diagnosed with autistic disorder. Gauthier J , et al. (2003) Yes -
6 Primary Association between the FOXP2 gene and autistic disorder in Chinese population. Gong X , et al. (2004) Yes -
7 Positive Association Absence of causative mutations and presence of autism-related allele in FOXP2 in Japanese autistic patients. Li H , et al. (2005) Yes -
8 Recent Recommendation Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. MacDermot KD , et al. (2005) No -
9 Negative Association No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. Marui T , et al. (2005) Yes -
10 Support Speech, prosody, and voice characteristics of a mother and daughter with a 7;13 translocation affecting FOXP2. Shriberg LD , et al. (2006) No -
11 Support Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. Feuk L , et al. (2006) No -
12 Recent Recommendation Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area X. Haesler S , et al. (2007) No -
13 Recent Recommendation Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Groszer M , et al. (2008) No -
14 Recent Recommendation Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2. Takahashi K , et al. (2008) No -
15 Recent Recommendation Conservation and diversity of Foxp2 expression in muroid rodents: functional implications. Campbell P , et al. (2008) No -
16 Recent Recommendation A functional genetic link between distinct developmental language disorders. Vernes SC , et al. (2008) No -
17 Recent Recommendation A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Enard W , et al. (2009) No -
18 Support Language features in a mother and daughter of a chromosome 7;13 translocation involving FOXP2. Tomblin JB , et al. (2009) No -
19 Recent Recommendation Human-specific transcriptional regulation of CNS development genes by FOXP2. Konopka G , et al. (2009) No -
20 Support Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex. Roll P , et al. (2010) No -
21 Negative association Association study of the CNS patterning genes and autism in Han Chinese in Taiwan. Chien YL , et al. (2011) Yes -
22 Support Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders. Schaaf CP , et al. (2011) Yes -
23 Support Epileptic encephalopathies of the Landau-Kleffner and continuous spike and waves during slow-wave sleep types: genomic dissection makes the link wi... Lesca G , et al. (2012) No ADHD
24 Recent recommendation Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization. Laffin JJ , et al. (2012) No -
25 Negative Association Analysis of two language-related genes in autism: a case-control association study of FOXP2 and CNTNAP2. Toma C , et al. (2013) Yes -
26 Recent Recommendation FOXP2 targets show evidence of positive selection in European populations. Ayub Q , et al. (2013) No -
27 Support Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria. Turner SJ , et al. (2013) No -
28 Support Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study (2014) No -
29 Support Comprehensive molecular testing in patients with high functioning autism spectrum disorder. Alvarez-Mora MI , et al. (2016) Yes -
30 Support FOXP2 variants in 14 individuals with developmental speech and language disorders broaden the mutational and clinical spectrum. Reuter MS , et al. (2016) No ASD (2 cases), autistic feature (1 case)
31 Recent recommendation Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c. Chen YC , et al. (2016) No -
32 Support The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies. Redin C , et al. (2016) No -
33 Support Functional characterization of rare FOXP2 variants in neurodevelopmental disorder. Estruch SB , et al. (2016) No -
34 Positive association The central nervous system patterning gene variants associated with clinical symptom severity of autism spectrum disorders. Chien YL , et al. (2017) Yes Severity of social reciprocity deficits (ADI-R, SC
Rare Variants   (70)
Status Allele Change Residue Change Variant Type Inheritance Pattern Parental Transmission Family Type Author, Year
c.1658G>A p.Arg553His missense_variant Familial Maternal & paternal Multi-generational Lai CS , et al. (2001)
- - translocation Unknown - - Lai CS , et al. (2001)
T>A p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
A>G p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
T>C p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
G>A p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
T>G p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
N/A N/A inframe_insertion Familial Maternal - Newbury DF , et al. (2002)
T>C p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
A>G p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
C>G p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
T>C p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
T>G p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
T>C p.(=) synonymous_variant - - - Newbury DF , et al. (2002)
N/A N/A inframe_deletion Familial Maternal - Wassink TH , et al. (2002)
N/A N/A inframe_deletion Familial Maternal Multiplex Wassink TH , et al. (2002)
c.741C>T p.(=) synonymous_variant - - - Wassink TH , et al. (2002)
T>G p.(=) synonymous_variant - - - Wassink TH , et al. (2002)
c.570A>G p.(=) synonymous_variant - - - Gauthier J , et al. (2003)
T>G p.(=) synonymous_variant - - - Gauthier J , et al. (2003)
C>G p.(=) synonymous_variant - - - Gauthier J , et al. (2003)
A>G p.(=) synonymous_variant - - - Gauthier J , et al. (2003)
c.570A>G p.(=) synonymous_variant - - - Li H , et al. (2005)
N/A N/A inframe_deletion - - - Li H , et al. (2005)
C>T p.(=) synonymous_variant - - - Li H , et al. (2005)
A>G p.(=) synonymous_variant - - - Li H , et al. (2005)
G>T p.(=) synonymous_variant - - - Li H , et al. (2005)
A>T p.(=) synonymous_variant - - - Li H , et al. (2005)
G to A - 5_prime_UTR_variant - - - MacDermot KD , et al. (2005)
G to A - 5_prime_UTR_variant - - - MacDermot KD , et al. (2005)
C>T p.(=) synonymous_variant - - - MacDermot KD , et al. (2005)
T>A p.(=) synonymous_variant - - - MacDermot KD , et al. (2005)
T>C p.(=) synonymous_variant - - - MacDermot KD , et al. (2005)
T>G p.(=) synonymous_variant - - - MacDermot KD , et al. (2005)
T>C p.(=) synonymous_variant - - - MacDermot KD , et al. (2005)
C>G p.(=) synonymous_variant - - - MacDermot KD , et al. (2005)
c.50A>T p.Gln17Leu missense_variant Unknown - Multiplex MacDermot KD , et al. (2005)
c.982C>T p.Arg328Ter stop_gained Familial Maternal Multi-generational MacDermot KD , et al. (2005)
N/A N/A inframe_insertion - - Multiplex MacDermot KD , et al. (2005)
- - translocation Unknown - - Feuk L , et al. (2006)
- - translocation Familial Maternal Multi-generational Tomblin JB , et al. (2009)
c.1217T>C p.Met406Thr missense_variant Familial Paternal Simplex Roll P , et al. (2010)
c.1321C>A p.Pro441Thr missense_variant Unknown - Simplex Schaaf CP , et al. (2011)
c.2012A>G p.Asn671Ser missense_variant Unknown - Simplex Schaaf CP , et al. (2011)
c.2159A>C p.His720Pro missense_variant Familial ( 1 case); De novo (1 case) Maternal (1 case) Simplex Schaaf CP , et al. (2011)
c.2175A>T p.Glu725Asp missense_variant Unknown - Simplex Schaaf CP , et al. (2011)
c.694_695insAGC p.Gln232delinsGlnGln inframe_insertion De novo (1 case); unknown (3 cases) - Simplex Schaaf CP , et al. (2011)
c.1468+9T>C - intron_variant Unknown - Unknown Lesca G , et al. (2012)
c.1217T>C p.Met406Thr missense_variant Unknown - Unknown Lesca G , et al. (2012)
c.1371T>C p.(=) synonymous_variant Unknown - Unknown Lesca G , et al. (2012)
c.1761G>A p.(=) synonymous_variant Unknown - Unknown Lesca G , et al. (2012)
c.1770-33G>A - intron_variant Unknown - Unknown Lesca G , et al. (2012)
c.522_524del p.Gln191del inframe_deletion Unknown - Unknown Lesca G , et al. (2012)
c.1789A>C p.Asn597His missense_variant Unknown - Multiplex Laffin JJ , et al. (2012)
c.398_399insT p.Leu135PhefsTer148 frameshift_variant Familial Paternal Simplex O'Roak BJ , et al. (2012)
c.1243_1244delCA p.Gln415ValfsTer5 frameshift_variant De novo - Simplex Turner SJ , et al. (2013)
c.1321C>A p.Pro441Thr missense_variant Familial Maternal Multiplex Turner SJ , et al. (2013)
T/C - intron_variant De novo - Unknown Deciphering Developmental Disorders Study (2014)
C/T - intron_variant De novo - Unknown Deciphering Developmental Disorders Study (2014)
A/G - intron_variant De novo - Unknown Deciphering Developmental Disorders Study (2014)
- p.Gln142His missense_variant Familial Paternal Multi-generational Alvarez-Mora MI , et al. (2016)
- - copy_number_loss De novo - Multiplex (monozygotic twins) Reuter MS , et al. (2016)
c.1057C>T p.Arg353Ter stop_gained Familial Maternal Multi-generational Reuter MS , et al. (2016)
c.1682G>C p.Arg561Pro missense_variant Familial Paternal Multi-generational Reuter MS , et al. (2016)
c.1507C>T p.Arg503Ter stop_gained De novo - Simplex Reuter MS , et al. (2016)
c.1765C>T p.Arg589Ter stop_gained De novo - Simplex Reuter MS , et al. (2016)
c.1689delT p.Phe563LeufsTer28 frameshift_variant De novo - Multiplex Reuter MS , et al. (2016)
c.1507C>T p.Arg503Ter stop_gained Familial Paternal Multi-generational Reuter MS , et al. (2016)
c.1589C>T p.Pro530Leu missense_variant Familial Paternal Multi-generational Reuter MS , et al. (2016)
- - complex_structural_alteration De novo - Simplex Redin C , et al. (2016)
Common Variants   (5)
Status Allele Change Residue Change Variant Type Inheritance Pattern Paternal Transmission Family Type Author, Year
c.1264-2019T>C;c.1267-2019T>C;c.1342-2019T>C;c.131 - intron_variant - - - Gong X , et al. (2004)
G to T N/A intron_variant - - - Li H , et al. (2005)
c.-11+5061A>T;c.-345+5061A>T;c.-11+5879A>T;c.-344- - intron_variant - - - Chien YL , et al. (2017)
c.169-26341C>A;c.168+81597C>A;c.*228+9183C>A - intron_variant - - - Chien YL , et al. (2017)
c.1264-2019T>C;c.1267-2019T>C;c.1342-2019T>C;c.131 - intron_variant - - - Chien YL , et al. (2017)
SFARI Gene score
3

Suggestive Evidence

A significant but unreplicated association study of FOXP2 in ASD has been reported. FOXP2 is mutated in specific language impairment, and also physically interacts with FOXP1, which has been implicated in ASD (PMID: 21572417)

3

Suggestive Evidence

See all Category 3 Genes

The literature is replete with relatively small studies of candidate genes, using either common or rare variant approaches, which do not reach the criteria set out for categories 1 and 2. Genes that had two such lines of supporting evidence were placed in category 3, and those with one line of evidence were placed in category 4. Some additional lines of “accessory evidence” (indicated as “acc” in the score cards) could also boost a gene from category 4 to 3.

01-01-2017
3

Initial score established: 3

Description

A significant but unreplicated association study of FOXP2 in ASD has been reported. FOXP2 is mutated in specific language impairment, and also physically interacts with FOXP1, which has been implicated in ASD (PMID: 21572417)

Reports Added
[h] [F]
CNVs associated with FOXP2(17 CNVs)
11q23.2 3 Deletion 7  /  24
12q24.21-q24.33 2 Duplication 5  /  2
13q11-q34 1 Duplication 2  /  2
13q12.11-q34 2 Duplication 4  /  4
13q13.2-q34 1 Duplication 2  /  1
13q14.11-q34 1 Duplication 2  /  3
13q21.1-q34 1 N/A 2  /  1
13q22.1-q34 1 Duplication 2  /  1
13q31.1-q34 1 Deletion-Duplication 2  /  2
13q31.3-q34 1 Deletion 2  /  1
13q32.3-q34 1 Deletion-Duplication 2  /  3
13q33.1-q34 3 Deletion 5  /  8
13q33.2-q34 2 Deletion-Duplication 4  /  11
13q33.3-qter 1 Deletion 1  /  1
13q34 19 Deletion-Duplication 33  /  161
4q25-q26 3 Duplication 5  /  3
Xq23 14 Deletion-Duplication 23  /  158
Interaction Table
Interactor Symbol Interactor Name Interactor Organism Interactor Type Entrez ID Uniprot ID
0610006I08RIK transmembrane protein 223 Mouse Protein Binding 66836 Q9CQE2
1110064P04RIK AHA1, activator of heat shock protein ATPase homolog 2 (yeast) Mouse Protein Binding 268390 Q8N9S3
1200013P24RIK N-acetyltransferase 15 (GCN5-related, putative) Mouse Protein Binding 74763 Q9DBU2
1300010M03RIK family with sequence similarity 134, member C Mouse Protein Binding 67998 Q9CQV4
1700009P03RIK RNA binding motif protein 26 Mouse Protein Binding 74213 Q6NZN0
1700054O13RIK RIKEN cDNA 1700054O13 gene Mouse Protein Binding 67334 A2AF56
1810011O10RIK RIKEN cDNA 1810011O10 gene Mouse Protein Binding 69068 Q9D915
1810037C20RIK family with sequence similarity 3, member A Mouse Protein Binding 66294 Q9D8T0
2010321M09RIK RIKEN cDNA 2010321M09 gene Mouse Protein Binding 69882 Q8R3P6
2200002K05RIK RIKEN cDNA 2200002K05 gene Mouse Protein Binding 69137 Q9D806
2310028H24RIK RIKEN cDNA 2310028H24 gene Mouse Protein Binding 71901 A2ANP1
2310057M21RIK RIKEN cDNA 2310057M21 gene Mouse Protein Binding 68277 Q9D2Q3
2310061I09RIK coiled-coil domain containing 115 Mouse Protein Binding 69668 Q8VE99
2510048L02RIK coiled-coil domain containing 159 Mouse Protein Binding 67119 Q8C963
2810002I04RIK family with sequence similarity 164, member C Mouse Protein Binding 72350 Q8CCG1
2810430M08RIK ribosomal RNA processing 15 homolog (S. cerevisiae) Mouse Protein Binding 67223 Q9CYX7
2900041A09RIK tubulin polymerization promoting protein Mouse Protein Binding 72948 Q7TQD2
3110043J09RIK Rho GTPase activating protein 8 Mouse Protein Binding 73167 Q9CXP4
3200002M19RIK RIKEN cDNA 3200002M19 gene Mouse Protein Binding 75430 P60007
4930408O21RIK PDZ domain containing 9 Mouse Protein Binding 67983 Q9D9M4
4933403G14RIK RIKEN cDNA 4933403G14 gene Mouse Protein Binding 74393 Q8BJS7
8430419L09RIK RIKEN cDNA 8430419L09 gene Mouse Protein Binding 74525 Q8BYI8
9230117E20RIK serine peptidase inhibitor, Kazal type 11 Mouse Protein Binding 78242 Q9D256
A130033B22 predicted gene 5094 Mouse Protein Binding 328839 N/A
A530082C11RIK solute carrier family 35, member E2 Mouse Protein Binding 320541 Q8C811
A730085E03RIK RIKEN cDNA A730085E03 gene Mouse Protein Binding 328983 N/A
A930001M12RIK transmembrane protein 215 Mouse Protein Binding 320500 A7E1Z1
AARD alanine and arginine rich domain containing protein Mouse Protein Binding 239435 Q811W1
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 Mouse Protein Binding 76184 Q8K441
ALOX12E arachidonate lipoxygenase, epidermal Mouse Protein Binding 11685 P55249
ARL11 ADP-ribosylation factor-like 11 Mouse Protein Binding 219144 Q6P3A9
ARPM1 actin related protein M1 Mouse Protein Binding 76652 Q8BXF8
BATF2 basic leucine zipper transcription factor, ATF-like 2 Mouse Protein Binding 74481 Q8R1H8
BC019537 solute carrier family 17, member 9 Mouse Protein Binding 228993 Q8VCL5
BC021442 zinc finger protein 758 Mouse Protein Binding 224598 E9Q462
BC035954 cDNA sequence BC035954 Mouse Protein Binding 194162 N/A
BC050188 tripartite motif family-like 1 Mouse Protein Binding 244448 Q8BVP1
BET1 blocked early in transport 1 homolog (S. cerevisiae) Mouse Protein Binding 12068 O35623
C78339 expressed sequence C78339 Mouse Protein Binding 97863 Q3URQ4
CATSPER3 cation channel, sperm associated 3 Mouse Protein Binding 76856 Q80W99
CBLN2 cerebellin 2 precursor protein Mouse Protein Binding 12405 Q8BGU2
CD53 CD53 antigen Mouse Protein Binding 12508 Q61451
CD59A CD59a antigen Mouse Protein Binding 12509 O55186
CDC2L6 cyclin-dependent kinase 19 Mouse Protein Binding 78334 Q8BWD8
CGA glycoprotein hormones, alpha subunit Mouse Protein Binding 12640 P01216
CHRNA1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) Mouse Protein Binding 11435 P04756
COL24A1 collagen, type XXIV, alpha 1 Mouse Protein Binding 71355 Q30D77
COL3A1 collagen, type III, alpha 1 Mouse Protein Binding 12825 P08121
CTRB1 chymotrypsinogen B1 Mouse Protein Binding 66473 Q9CR35
D030041N04RIK leucine zipper-EF-hand containing transmembrane protein 2 Mouse Protein Binding 270035 Q7TNU7
D11ERTD730E SLU7 splicing factor homolog (S. cerevisiae) Mouse Protein Binding 193116 Q8BHJ9
D330045A20RIK RIKEN cDNA D330045A20 gene Mouse Protein Binding 102871 Q8C779
D830007B15RIK shisa homolog 3 (Xenopus laevis) Mouse Protein Binding 330096 Q3UPR0
DSG4 Desmoglein-4 Human Protein Binding 147409 Q86SJ6-2
DSPG3 epiphycan Mouse Protein Binding 13516 P70186
EIF3S10 eukaryotic translation initiation factor 3, subunit A Mouse Protein Binding 13669 P23116
EMX2 empty spiracles homolog 2 (Drosophila) Mouse Protein Binding 13797 Q04744
FAM124A family with sequence similarity 124A Human Protein Binding 220108 Q86V42
FGF1 fibroblast growth factor 1 Mouse Protein Binding 14164 P61148
FMO2 flavin containing monooxygenase 2 Mouse Protein Binding 55990 Q8K2I3
FXYD2 FXYD domain-containing ion transport regulator 2 Mouse Protein Binding 11936 Q04646
GALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 Mouse Protein Binding 78752 Q8C1F4
GGN gametogenetin Mouse Protein Binding 243897 Q80WJ1
GM1553 predicted gene 1553 Mouse Protein Binding 432480 Q66VB7
IL12B interleukin 12b Mouse Protein Binding 16160 P43432
KLRE1 killer cell lectin-like receptor family E member 1 Mouse Protein Binding 243655 Q8CJC7
LIPC lipase, hepatic Mouse Protein Binding 15450 P27656
LOC433178 serine peptidase inhibitor, Kazal type 14 Mouse Protein Binding 433178 B9EJP9
LRRC15 leucine rich repeat containing 15 Human Protein Binding 131578 Q8TF66
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) Mouse Protein Binding 17149 P61327
MMU-LET-7A-1 microRNA let7a-1 Mouse Protein Binding 387244 N/A
MMU-MIR-137 microRNA 137 Mouse Protein Binding 387155 N/A
MMU-MIR-19B-1 microRNA 19b-2 Mouse Protein Binding 387195 N/A
MMU-MIR-469 microRNA 469 Mouse Protein Binding 723872 N/A
NRN1 neuritin 1 Mouse Protein Binding 68404 Q8CFV4
NSG1 neuron specific gene family member 1 Mouse Protein Binding 18196 Q62092
OC90 otoconin 90 Mouse Protein Binding 18256 Q9Z0L3
OLFR113 olfactory receptor 113 Mouse Protein Binding 258286 Q8VEU4
OLFR1184 olfactory receptor 1184 Mouse Protein Binding 258820 Q8VG86
OLFR131 olfactory receptor 131 Mouse Protein Binding 258867 Q8VGC8
OLFR1388 olfactory receptor 1388 Mouse Protein Binding 258459 Q8VFA3
OLFR139 olfactory receptor 139 Mouse Protein Binding 259005 Q60891
OLFR1465 olfactory receptor 1465 Mouse Protein Binding 258121 Q7TQR2
OLFR26 olfactory receptor 26 Mouse Protein Binding 18324 Q7TRB7
OLFR284 olfactory receptor 284 Mouse Protein Binding 258278 Q8VET7
OLFR305 olfactory receptor 305 Mouse Protein Binding 258609 Q7TS02
OLFR461 olfactory receptor 461 Mouse Protein Binding 258380 Q8VF30
OLFR487 olfactory receptor 487 Mouse Protein Binding 258042 Q7TRU9
OLFR711 olfactory receptor 711 Mouse Protein Binding 259037 Q9EPG2
OLFR723 olfactory receptor 723 Mouse Protein Binding 259147 E9PZU2
OLFR978 olfactory receptor 978 Mouse Protein Binding 259109 E9Q985
PBEF1 nicotinamide phosphoribosyltransferase Mouse Protein Binding 59027 Q99KQ4
PCDHA2 protocadherin alpha 2 Mouse Protein Binding 353234 Q05C01
PCOLN3 chromatin modifying protein 1A Mouse Protein Binding 234852 Q921W0
PIGC phosphatidylinositol glycan anchor biosynthesis, class C Mouse Protein Binding 67292 Q9CXR4
PKDREJ polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin) Mouse Protein Binding 18766 Q9Z0T6
PKP3 Plakophilin-3 Human Protein Binding 11187 Q9Y446
PLA2G10 phospholipase A2, group X Mouse Protein Binding 26565 Q9QXX3
PRLPM prolactin family 2, subfamily a, member 1 Mouse Protein Binding 56635 Q9JHK0
PRMT4 coactivator-associated arginine methyltransferase 1 Mouse Protein Binding 59035 Q9WVG6
PRSS2 protease, serine, 2 Mouse Protein Binding 22072 P07146
PSTK phosphoseryl-tRNA kinase Mouse Protein Binding 214580 Q8BP74
PTTG1 pituitary tumor-transforming gene 1 Mouse Protein Binding 30939 Q9CQJ7
RAB3C RAB3C, member RAS oncogene family Mouse Protein Binding 67295 P62823
RAB9B RAB9B, member RAS oncogene family Mouse Protein Binding 319642 Q8BHH2
RHOJ ras homolog gene family, member J Mouse Protein Binding 80837 Q9ER71
RLN1 relaxin 1 Mouse Protein Binding 19773 A2RTV8
RNF17 ring finger protein 17 Mouse Protein Binding 30054 Q99MV7
ROBO4 roundabout homolog 4 (Drosophila) Mouse Protein Binding 74144 Q8C310
S100A2 S100 calcium binding protein A2 Human Protein Binding 6273 P29034
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D Mouse Protein Binding 214968 Q76KF0
SLC12A9 solute carrier family 12 (potassium/chloride transporters), member 9 Mouse Protein Binding 83704 Q99MR3
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Mouse Protein Binding 114644 Q91Y63
SLC14A1 solute carrier family 14 (urea transporter), member 1 Mouse Protein Binding 108052 Q8VHL0
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 Mouse Protein Binding 18399 Q8VC69
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Mouse Protein Binding 214111 Q91WD8
SMC5L1 structural maintenance of chromosomes 5 Mouse Protein Binding 226026 Q8CG46
SPATA17 spermatogenesis associated 17 Mouse Protein Binding 74717 Q9D552
SPESP1 sperm equatorial segment protein 1 Mouse Protein Binding 66712 Q9D5A0
SRPX2 sushi-repeat containing protein, X-linked 2 Human DNA Binding 27286 O60687
STEAP1 six transmembrane epithelial antigen of the prostate 1 Mouse Protein Binding 70358 Q9CWR7
SVS1 seminal vesicle secretory protein 1 Mouse Protein Binding 243377 Q6WIZ7
TAAR5 trace amine-associated receptor 5 Mouse Protein Binding 215854 Q5QD14
TBC1D19 TBC1 domain family, member 19 Mouse Protein Binding 67249 Q8VDV7
TCFAP2D transcription factor AP-2, delta Mouse Protein Binding 226896 Q91ZK0
TCTE1 t-complex-associated testis expressed 1 Mouse Protein Binding 21645 A6H639
TMEM55A transmembrane protein 55A Mouse Protein Binding 72519 Q9CZX7
TRAF3IP3 TRAF3 interacting protein 3 Mouse Protein Binding 215243 Q8C0G2
TSACC TSSK6 activating co-chaperone Human Protein Binding 128229 Q96A04
TSPAN10 tetraspanin 10 Mouse Protein Binding 208634 Q8VCF5
V1RB1 vomeronasal 1 receptor 50 Mouse Protein Binding 113852 Q9EP51
WBP5 WW domain binding protein 5 Mouse Protein Binding 22381 Q9DD24
ZCCHC5 zinc finger, CCHC domain containing 5 Mouse Protein Binding 213436 Q6P1Y1
ZFP248 zinc finger protein 248 Mouse Protein Binding 72720 Q640N4
ZFP36 zinc finger protein 36 Mouse Protein Binding 22695 P22893
ZFP521 zinc finger protein 521 Mouse Protein Binding 225207 Q6KAS7
ZSWIM2 zinc finger, SWIM domain containing 2 Mouse Protein Binding 71861 Q9D9X6
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