Human Gene Module / Chromosome 17 / NCOR1

NCOR1nuclear receptor corepressor 1

Score
2
Strong Candidate Criteria 2.1
Autism Reports / Total Reports
4 / 6
Rare Variants / Common Variants
8 / 0
Aliases
NCOR1, N-CoR,  N-CoR1,  PPP1R109,  TRAC1,  hN-CoR
Associated Syndromes
-
Genetic Category
Rare Single Gene Mutation, Functional
Chromosome Band
17p12-p11.2
Associated Disorders
ASD
Relevance to Autism

A de novo potentially damaging missense variant in the NCOR1 gene was identified in an ASD proband from the Simons Simplex Collection (Iossifov et al., 2012); a de novo splice-site variant and paternally-inherited potentially damaging missense variant in this gene were identified in ASD probands from the Autism Clinical and Genetic Resources in China (ACGC) cohort (Wang et al., 2016). Interaction of the NCoR/SMRT co-repressor with MECP2 is abolished by mutations associated with Rett syndrome (Lyst et al., 2013).

Molecular Function

This gene encodes a protien that mediates transcriptional repression by certain nuclear receptors and is part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.

Reports related to NCOR1 (6 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Primary De novo gene disruptions in children on the autistic spectrum. Iossifov I , et al. (2012) Yes -
2 Support Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Lyst MJ , et al. (2013) No -
3 Support De novo genic mutations among a Chinese autism spectrum disorder cohort. Wang T , et al. (2016) Yes -
4 Support Haploinsufficiency of NCOR1 associated with autism spectrum disorder, scoliosis, and abnormal palatogenesis. Sakaguchi Y , et al. (2018) Yes -
5 Support Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model. Guo H , et al. (2018) Yes -
6 Recent Recommendation Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Zhou W , et al. (2019) No ASD
Rare Variants   (8)
Status Allele Change Residue Change Variant Type Inheritance Pattern Parental Transmission Family Type PubMed ID Author, Year
- - copy_number_loss De novo - - 30664766 Zhou W , et al. (2019)
c.3449-1G>C p.? splice_site_variant De novo - - 27824329 Wang T , et al. (2016)
c.2182+2T>G p.? splice_site_variant De novo - - 30664766 Zhou W , et al. (2019)
c.2182+1G>T p.? splice_site_variant De novo - - 30289594 Sakaguchi Y , et al. (2018)
c.3122C>T p.Pro1025Leu missense_variant Familial Paternal - 27824329 Wang T , et al. (2016)
c.1705C>T p.Pro569Ser missense_variant De novo - Simplex 22542183 Iossifov I , et al. (2012)
c.2930G>A p.Arg977Gln missense_variant Familial Paternal Simplex 30564305 Guo H , et al. (2018)
c.5849G>A p.Arg1950His missense_variant Familial Maternal Simplex 30564305 Guo H , et al. (2018)
Common Variants  

No common variants reported.

SFARI Gene score
2

Strong Candidate

A de novo potentially damaging missense variant in the NCOR1 gene was identified in an ASD proband from the Simons Simplex Collection (Iossifov et al., 2012); a de novo splice-site variant and paternally-inherited potentially damaging missense variant in this gene were identified in ASD probands from the Autism Clinical and Genetic Resources in China (ACGC) cohort (Wang et al., 2016). A second de novo splice-site variant in the NCOR1 gene was identified in a Japanese girl diagnosed with ASD in Sakaguchi et al., 2018. Interaction of the NCoR/SMRT co-repressor with MECP2 is abolished by mutations associated with Rett syndrome (Lyst et al., 2013). Zhou et al., 2019 demonstrated that mice with knock-in mutations in the deacetylase activation domains of NCOR1 and NCOR2 exhibited memory deficits, reduced anxiety levels, and reduced social interactions; in the same report, a de novo splice-site variant in the NCOR1 gene found in an 8-year-old boy with ASD, developmental delay, and epilepsy was retrieved from the Deciphering Developmental Disorders (DDD) website.

Score Delta: Score remained at 2

2

Strong Candidate

See all Category 2 Genes

We considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.

1/1/2019
3
icon
2

Decreased from 3 to 2

Description

A de novo potentially damaging missense variant in the NCOR1 gene was identified in an ASD proband from the Simons Simplex Collection (Iossifov et al., 2012); a de novo splice-site variant and paternally-inherited potentially damaging missense variant in this gene were identified in ASD probands from the Autism Clinical and Genetic Resources in China (ACGC) cohort (Wang et al., 2016). A second de novo splice-site variant in the NCOR1 gene was identified in a Japanese girl diagnosed with ASD in Sakaguchi et al., 2018. Interaction of the NCoR/SMRT co-repressor with MECP2 is abolished by mutations associated with Rett syndrome (Lyst et al., 2013). Zhou et al., 2019 demonstrated that mice with knock-in mutations in the deacetylase activation domains of NCOR1 and NCOR2 exhibited memory deficits, reduced anxiety levels, and reduced social interactions; in the same report, a de novo splice-site variant in the NCOR1 gene found in an 8-year-old boy with ASD, developmental delay, and epilepsy was retrieved from the Deciphering Developmental Disorders (DDD) website.

10/1/2018
4
icon
3

Decreased from 4 to 3

Description

A de novo potentially damaging missense variant in the NCOR1 gene was identified in an ASD proband from the Simons Simplex Collection (Iossifov et al., 2012); a de novo splice-site variant and paternally-inherited potentially damaging missense variant in this gene were identified in ASD probands from the Autism Clinical and Genetic Resources in China (ACGC) cohort (Wang et al., 2016). A second de novo splice-site variant in the NCOR1 gene was identified in a Japanese girl diagnosed with ASD in Sakaguchi et al., 2018. Interaction of the NCoR/SMRT co-repressor with MECP2 is abolished by mutations associated with Rett syndrome (Lyst et al., 2013).

10/1/2016
icon
4

Increased from to 4

Description

A de novo potentially damaging missense variant in the NCOR1 gene was identified in an ASD proband from the Simons Simplex Collection (Iossifov et al., 2012); a de novo splice-site variant and paternally-inherited potentially damaging missense variant in this gene were identified in ASD probands from the Autism Clinical and Genetic Resources in China (ACGC) cohort (Wang et al., 2016). Interaction of the NCoR/SMRT co-repressor with MECP2 is abolished by mutations associated with Rett syndrome (Lyst et al., 2013).

Krishnan Probability Score

Score 0.51230585606491

Ranking 1807/25841 scored genes


[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning approach on a human brain-specific gene network. The method was first presented in Nat Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed in column G of supplementary table 3 (see: http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser, with the ability to view networks of associated ASD risk genes, can be found at asd.princeton.edu.
ExAC Score

Score 0.99999999925682

Ranking 94/18225 scored genes


[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of- function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of- function mutations in autism in such a gene would be more likely to confer risk. For a full list of pLI scores see: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle aned_exac_nonTCGA_z_pli_rec_null_data.txt
Iossifov Probability Score

Score 0.876

Ranking 169/239 scored genes


[Show Scoring Methodology]
Supplementary dataset S2 in the paper by Iossifov et al. (PNAS 112, E5600-E5607 (2015)) lists 239 genes with a probability of at least 0.8 of being associated with autism risk (column I). This probability metric combines the evidence from de novo likely-gene- disrupting and missense mutations and assesses it against the background mutation rate in unaffected individuals from the University of Washington’s Exome Variant Sequence database (evs.gs.washington.edu/EVS/). The list of probability scores can be found here: www.pnas.org/lookup/suppl/doi:10.1073/pnas.1516376112/- /DCSupplemental/pnas.1516376112.sd02.xlsx
Sanders TADA Score

Score 0.93565955885736

Ranking 12947/18665 scored genes


[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013), and is a statistic that integrates evidence from both de novo and transmitted mutations. It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233 (2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper (the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Zhang D Score

Score 0.4518079724158

Ranking 904/20870 scored genes


[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures), or D score, was developed to combine evidence from de novo loss-of- function mutation with evidence from cell-type- specific gene expression in the mouse brain (specifically translational profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with positive D scores are more likely to be associated with autism risk, with higher-confidence genes having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204- 215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in supplementary table 2 from that paper.
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