Human Gene Module / Chromosome 22 / SHANK3

SHANK3SH3 and multiple ankyrin repeat domains 3

SFARI Gene Score
1
High Confidence Criteria 1.1
Autism Reports / Total Reports
59 / 114
Rare Variants / Common Variants
1 / 9
EAGLE Score
74.85
Strong Learn More
Aliases
SHANK3, PSAP2,  PROSAP2,  SPANK-2,  KIAA1650
Associated Syndromes
Phelan-McDermid syndrome, Rett syndrome-like phenotype
Chromosome Band
22q13.33
Associated Disorders
DD/NDD, BPD, ID, EPS, ASD
Genetic Category
Rare Single Gene Mutation, Syndromic, Genetic Association, Functional
Relevance to Autism

Recurrent mutations in the SHANK3 gene have been identified in multiple individuals with ASD as described below. SHANK3 lies within a multi-genic region on chromosome 22 that is deleted in Phelan-McDermid syndrome, a disorder which is frequently accompanied by ASD. De novo and inherited point mutations and copy number variants involving SHANK3 have been identified in individuals with ASD in multiple reports (PMIDs 17173049, 17999366, 18615476, 20186804, 20385823, 21378602, 21624971, 22558107, 22892527, 23758760), including de novo SHANK3 variants in PMIDs 17173049, 17999366 and 18615476 that were predicted to be loss-of-function variants or shown experimentally to disrupt SHANK3 function. An additional seven de novo loss-of-function variants in SHANK3 were identified in simplex ASD cases in Leblond et al., 2014 (PMID 25188300); in contrast, no truncating variants in SHANK3 were observed in 1,031 controls. Individuals with truncating SHANK3 variants were found to display ASD with moderate to severe/profound intellectual disability (mean IQ of 31 8) in this report. Furthermore, in a screen and meta-analysis of SHANK copy number variants in ASD, SHANK3 deletions were shown to be statistically enriched in ASD cases compared to controls [10/5,657 cases (0.18%) vs. 2/19,163 controls (0.01); P=0.019, OR=4.05 (1.26-13.01)] (PMID 25188300). This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017). Multiple inconsistent associations have been reported with idiopathic ASD in other studies (PMIDs 19384346, 19566951, 22892527, 24398551, 27876814). De novo SHANK3 mutations in individuals with schizophrenia have also been reported in Gauthier et al., 2010 (PMID 20385823), and association of SHANK3 with schizophrenia has been reported as well (PMID 28371232).

Molecular Function

Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation.

SFARI Genomic Platforms
Reports related to SHANK3 (114 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Highly Cited Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family Boeckers TM , et al. (1999) No -
2 Recent Recommendation An architectural framework that may lie at the core of the postsynaptic density Baron MK , et al. (2006) No -
3 Primary Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders Durand CM , et al. (2006) Yes -
4 Support Contribution of SHANK3 mutations to autism spectrum disorder Moessner R , et al. (2007) Yes -
5 Recent Recommendation Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1 Hung AY , et al. (2008) No -
6 Recent Recommendation Heterogeneous dysregulation of microRNAs across the autism spectrum Abu-Elneel K , et al. (2008) No -
7 Support Novel de novo SHANK3 mutation in autistic patients Gauthier J , et al. (2008) Yes -
8 Negative Association Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection Sykes NH , et al. (2009) Yes -
9 Recent Recommendation Chromosome 22q13.3 deletion syndrome with a de novo interstitial 22q13.3 cryptic deletion disrupting SHANK3 Delahaye A , et al. (2009) No -
10 Recent Recommendation ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3 Liebau S , et al. (2009) No -
11 Negative Association Association study of SHANK3 gene polymorphisms with autism in Chinese Han population Qin J , et al. (2009) Yes -
12 Recent Recommendation Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease Gong Y , et al. (2009) No -
13 Recent Recommendation Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses Schmeisser MJ , et al. (2009) No -
14 Recent Recommendation 22q13.3 deletion syndrome: clinical and molecular analysis using array CGH Dhar SU , et al. (2010) No MR
15 Recent Recommendation De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia Gauthier J , et al. (2010) No -
16 Support Direct measure of the de novo mutation rate in autism and schizophrenia cohorts Awadalla P , et al. (2010) Yes -
17 Negative Association Analysis of a purported SHANK3 mutation in a boy with autism: clinical impact of rare variant research in neurodevelopmental disabilities Kolevzon A , et al. (2010) Yes -
18 Support Novel variants of the SHANK3 gene in Japanese autistic patients with severe delayed speech development Waga C , et al. (2011) Yes -
19 Recent Recommendation Shank3 mutant mice display autistic-like behaviours and striatal dysfunction Pea J , et al. (2011) No -
20 Negative Association Association study of the CNS patterning genes and autism in Han Chinese in Taiwan Chien YL , et al. (2011) Yes -
21 Support SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism Durand CM , et al. (2011) No -
22 Support Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders Schaaf CP , et al. (2011) Yes -
23 Support High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism Kelleher RJ 3rd , et al. (2012) Yes -
24 Recent Recommendation Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders Boccuto L , et al. (2012) Yes -
25 Support Bipolar affective disorder and early dementia onset in a male patient with SHANK3 deletion Vucurovic K , et al. (2012) No ID
26 Negative Association Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population Liu Y , et al. (2013) Yes -
27 Recent Recommendation Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation Raynaud F , et al. (2013) No -
28 Recent Recommendation Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency Soorya L , et al. (2013) Yes ID, epilepsy/seizures
29 Recent Recommendation SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region Mameza MG , et al. (2013) Yes -
30 Support Performance comparison of bench-top next generation sequencers using microdroplet PCR-based enrichment for targeted sequencing in patients with autism spectrum disorder Koshimizu E , et al. (2013) Yes ID, epilepsy
31 Recent Recommendation Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism Duffney LJ , et al. (2013) No -
32 Recent Recommendation Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders Zhu L , et al. (2013) No -
33 Recent Recommendation The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation Grabrucker S , et al. (2014) No -
34 Positive Association A commonly carried genetic variant, rs9616915, in SHANK3 gene is associated with a reduced risk of autism spectrum disorder: replication in a Chinese population Shao S , et al. (2014) Yes -
35 Recent Recommendation Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice Wang X , et al. (2014) No -
36 Support Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing Redin C , et al. (2014) No -
37 Recent Recommendation Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments Leblond CS , et al. (2014) Yes -
38 Support Refining analyses of copy number variation identifies specific genes associated with developmental delay Coe BP , et al. (2014) Yes -
39 Support Synaptic, transcriptional and chromatin genes disrupted in autism De Rubeis S , et al. (2014) Yes -
40 Support Recurrent de novo mutations implicate novel genes underlying simplex autism risk O'Roak BJ , et al. (2014) Yes -
41 Support Large-scale discovery of novel genetic causes of developmental disorders Deciphering Developmental Disorders Study (2014) No Speech delay
42 Support Whole-genome sequencing of quartet families with autism spectrum disorder Yuen RK , et al. (2015) Yes -
43 Support Whole genome sequencing reveals a de novo SHANK3 mutation in familial autism spectrum disorder Nemirovsky SI , et al. (2015) Yes -
44 Recent Recommendation Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis Kozol RA , et al. (2015) No -
45 Support De novo SHANK3 mutation causes Rett syndrome-like phenotype in a female patient Hara M , et al. (2015) No DD, autistic features, stereotyped hand movements,
46 Support Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID Cochoy DM , et al. (2015) Yes -
47 Recent Recommendation Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits Speed HE , et al. (2015) No -
48 Recent Recommendation Low load for disruptive mutations in autism genes and their biased transmission Iossifov I , et al. (2015) Yes -
49 Support Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci Sanders SJ , et al. (2015) Yes -
50 Support Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller's dementia infantilis, a rare subtype of autism spectrum disorder Philippe A , et al. (2015) No Developmental regression
51 Support Gene Mutation Analysis in 253 Chinese Children with Unexplained Epilepsy and Intellectual/Developmental Disabilities Zhang Y , et al. (2015) No -
52 Recent Recommendation Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons Yi F , et al. (2016) No -
53 Support Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability Lelieveld SH et al. (2016) No -
54 Support Copy number variation analysis in adults with catatonia confirms haploinsufficiency of SHANK3 as a predisposing factor Breckpot J , et al. (2016) No -
55 Support Genome-wide characteristics of de novo mutations in autism Yuen RK et al. (2016) Yes -
56 Support The spectrum of epilepsy and electroencephalographic abnormalities due to SHANK3 loss-of-function mutations Holder JL Jr and Quach MM (2016) No -
57 Recent Recommendation Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength Arons MH , et al. (2016) No -
58 Positive Association A genome-wide investigation into parent-of-origin effects in autism spectrum disorder identifies previously associated genes including SHANK3 Connolly S , et al. (2016) Yes -
59 Support Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder C Yuen RK et al. (2017) Yes -
60 Support SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras Lilja J , et al. (2017) No -
61 Support Investigation of SHANK3 in schizophrenia de Sena Cortabitarte A , et al. (2017) No -
62 Support Neurogenetic analysis of childhood disintegrative disorder Gupta AR , et al. (2017) No -
63 Support Genomic diagnosis for children with intellectual disability and/or developmental delay Bowling KM , et al. (2017) No -
64 Support Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder Lim ET , et al. (2017) Yes -
65 Positive Association Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism Koberstein JN , et al. (2018) Yes -
66 Negative Association Association between SHANK3 polymorphisms and susceptibility to autism spectrum disorder Qiu S , et al. (2018) Yes -
67 Support Two de novo novel mutations in one SHANK3 allele in a patient with autism and moderate intellectual disability Zhu W , et al. (2018) Yes -
68 Recent Recommendation Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations De Rubeis S , et al. (2018) No ASD
69 Support Genetic Diagnostic Evaluation of Trio-Based Whole Exome Sequencing Among Children With Diagnosed or Suspected Autism Spectrum Disorder Du X , et al. (2018) Yes DD/ID
70 Recent Recommendation An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function Wang L , et al. (2019) Yes -
71 Recent Recommendation Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations Gouder L , et al. (2019) No -
72 Support Targeted resequencing of 358 candidate genes for autism spectrum disorder in a Chinese cohort reveals diagnostic potential and genotype-phenotype correlations Zhou WZ , et al. (2019) Yes -
73 Support Lessons Learned from Large-Scale, First-Tier Clinical Exome Sequencing in a Highly Consanguineous Population Monies D , et al. (2019) No -
74 Recent Recommendation Atypical behaviour and connectivity in SHANK3-mutant macaques Zhou Y , et al. (2019) Yes -
75 Support Characterization of intellectual disability and autism comorbidity through gene panel sequencing Aspromonte MC , et al. (2019) Yes -
76 Recent Recommendation Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility Yoo YE , et al. (2019) No -
77 Support Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks Ruzzo EK , et al. (2019) Yes -
78 Support Impact of on-site clinical genetics consultations on diagnostic rate in children and young adults with autism spectrum disorder Munnich A , et al. (2019) Yes -
79 Support Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes Feliciano P et al. (2019) Yes -
80 Recent Recommendation Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5 Scheefhals N , et al. (2019) No -
81 Support A 22q13.33 duplication harbouring the SHANK3 gene: does it cause neuropsychiatric disorders? Johannessen M , et al. (2019) Yes Tourette syndrome, BPD
82 Support Meta-Analyses Support Previous and Novel Autism Candidate Genes: Outcomes of an Unexplored Brazilian Cohort da Silva Montenegro EM , et al. (2019) Yes -
83 Support Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism Satterstrom FK et al. (2020) Yes -
84 Support Rare genetic susceptibility variants assessment in autism spectrum disorder: detection rate and practical use Husson T , et al. (2020) Yes -
85 Support Truncating mutations in SHANK3 associated with global developmental delay interfere with nuclear ?-catenin signaling Hassani Nia F et al. (2020) No -
86 Support Utility of clinical exome sequencing in a complex Emirati pediatric cohort Mahfouz NA et al. (2020) Yes -
87 Support Next-Generation Sequencing in Korean Children With Autism Spectrum Disorder and Comorbid Epilepsy Lee J et al. (2020) Yes -
88 Support Targeted next-generation sequencing identifies the disruption of the SHANK3 and RYR2 genes in a patient carrying a de novo t(1;22)(q43;q13.3) associated with signs of Phelan-McDermid syndrome Bonaglia MC et al. (2020) No Autistic features, stereotypy
89 Support A 29 Mainland Chinese cohort of patients with Phelan-McDermid syndrome: genotype-phenotype correlations and the role of SHANK3 haploinsufficiency in the important phenotypes Xu N et al. (2020) No -
90 Support - Mojarad BA et al. (2021) No ID
91 Support - Brunet T et al. (2021) No -
92 Support - Bucher M et al. (2021) Yes -
93 Support - Zou D et al. (2021) Yes -
94 Support - Lee DK et al. (2021) Yes -
95 Support - Golden CEM et al. (2021) No -
96 Support - Moutin E et al. (2021) Yes -
97 Support - Valentino F et al. (2021) Yes DD, epilepsy/seizures
98 Support - Trakadis Y et al. (2021) No ADHD, DD
99 Support - Kankuri-Tammilehto M et al. (2021) No ASD, ID, epilepsy/seizures
100 Support - Levy T et al. (2021) No -
101 Support - Pode-Shakked B et al. (2021) Yes -
102 Support - Mitani T et al. (2021) No Autistic behavior
103 Support - Salomaa SI et al. (2021) No -
104 Support - Mahjani B et al. (2021) Yes -
105 Recent Recommendation - Loureiro LO et al. (2021) Yes ADHD, epilepsy/seizures
106 Support - Lin R et al. (2021) No -
107 Support - Balasco L et al. (2021) Yes -
108 Support - Bruno LP et al. (2021) Yes -
109 Support - Woike D et al. (2022) No ASD
110 Support - Krüttner S et al. (2022) Yes -
111 Support - Brea-Fernández AJ et al. (2022) No -
112 Support - Kim H et al. (2022) Yes -
113 Support - Wu CH et al. (2022) No -
114 Support - Nevado J et al. (2022) No ASD
Rare Variants   (1)
Status Allele Change Residue Change Variant Type Inheritance Pattern Parental Transmission Family Type PubMed ID Author, Year
Common Variants   (9)
Status Allele Change Residue Change Variant Type Inheritance Pattern Paternal Transmission Family Type PubMed ID Author, Year
c.1304+48C>T - intron_variant - - - 22892527 Boccuto L , et al. (2012)
c.2134+407G>A - intron_variant - - - 27876814 Connolly S , et al. (2016)
c.2351-595G>C - intron_variant - - - 29339533 Koberstein JN , et al. (2018)
c.734T>C p.Ile245Thr missense_variant - - - 24398551 Shao S , et al. (2014)
c.886-60C>G - intron_variant - - - 28371232 de Sena Cortabitarte A , et al. (2017)
c.1612+18T>C - intron_variant - - - 28371232 de Sena Cortabitarte A , et al. (2017)
c.1797G>A p.(=) synonymous_variant - - - 28371232 de Sena Cortabitarte A , et al. (2017)
c.4947C>T p.(=) synonymous_variant - - - 28371232 de Sena Cortabitarte A , et al. (2017)
c.2161G>A p.Ala721Thr missense_variant - - - 28371232 de Sena Cortabitarte A , et al. (2017)
SFARI Gene score
1

High Confidence

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1

High Confidence

See all Category 1 Genes

We considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.

Krishnan Probability Score

Score 0.49156990996817

Ranking 5402/25841 scored genes


[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning approach on a human brain-specific gene network. The method was first presented in Nat Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed in column G of supplementary table 3 (see: http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser, with the ability to view networks of associated ASD risk genes, can be found at asd.princeton.edu.
ExAC Score

Score 0.99983961998191

Ranking 753/18225 scored genes


[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of- function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of- function mutations in autism in such a gene would be more likely to confer risk. For a full list of pLI scores see: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle aned_exac_nonTCGA_z_pli_rec_null_data.txt
Iossifov Probability Score

Score 0.9

Ranking 139/239 scored genes


[Show Scoring Methodology]
Supplementary dataset S2 in the paper by Iossifov et al. (PNAS 112, E5600-E5607 (2015)) lists 239 genes with a probability of at least 0.8 of being associated with autism risk (column I). This probability metric combines the evidence from de novo likely-gene- disrupting and missense mutations and assesses it against the background mutation rate in unaffected individuals from the University of Washington’s Exome Variant Sequence database (evs.gs.washington.edu/EVS/). The list of probability scores can be found here: www.pnas.org/lookup/suppl/doi:10.1073/pnas.1516376112/- /DCSupplemental/pnas.1516376112.sd02.xlsx
Sanders TADA Score

Score 0.0009855281567879

Ranking 19/18665 scored genes


[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013), and is a statistic that integrates evidence from both de novo and transmitted mutations. It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233 (2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper (the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Larsen Cumulative Evidence Score

Score 350

Ranking 1/461 scored genes


[Show Scoring Methodology]
Larsen and colleagues generated gene scores based on the sum of evidence for all available ASD-associated variants in a gene, with assessments based on mode of inheritance, effect size, and variant frequency in the general population. The approach was first presented in Mol Autism 7:44 (2016), and scores for 461 genes can be found in column I in supplementary table 4 from that paper.
Zhang D Score

Score 0.44970025156365

Ranking 924/20870 scored genes


[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures), or D score, was developed to combine evidence from de novo loss-of- function mutation with evidence from cell-type- specific gene expression in the mouse brain (specifically translational profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with positive D scores are more likely to be associated with autism risk, with higher-confidence genes having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204- 215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in supplementary table 2 from that paper.
Interaction Table
Interactor Symbol Interactor Name Interactor Organism Interactor Type Entrez ID Uniprot ID
AGAP7 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7 Human Protein Binding 653268 Q5VUJ5
C6orf154 chromosome 6 open reading frame 154 Human Protein Binding 221424 Q5JTD7
CA10 carbonic anhydrase X Human Protein Binding 56934 Q9NS85
FRS3 fibroblast growth factor receptor substrate 3 Human Protein Binding 10817 O43559
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Human Protein Binding 23072 Q76N89
IGSF9 immunoglobulin superfamily, member 9 Human Protein Binding 57549 Q9P2J2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) Human Protein Binding 9358 O95965
LOC727948 LOC727948similar to KIAA0454 protein Human Protein Binding 727948 N/A
MEGF11 multiple EGF-like-domains 11 Human Protein Binding 84465 A6BM72
N4BP3 NEDD4 binding protein 3 Human Protein Binding 23138 O15049
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Human Protein Binding 57664 Q9H4M7
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta Human Protein Binding 28227 Q9Y5P8
ROA0 Heterogeneous nuclear ribonucleoprotein A0 Mouse Protein Binding 77134 Q9CX86
ROA2 Heterogeneous nuclear ribonucleoproteins A2/B1 Mouse Protein Binding 102642938 O88569
ROA3 Heterogeneous nuclear ribonucleoprotein A3 Mouse Protein Binding 229279 Q8BG05
RUNDC3A RUN domain containing 3A Human Protein Binding 10900 Q59EK9
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