SORCS3sortilin related VPS10 domain containing receptor 3
Autism Reports / Total Reports
3 / 7Rare Variants / Common Variants
2 / 5Aliases
SORCS3, SORCSAssociated Syndromes
-Chromosome Band
10q25.1Associated Disorders
-Relevance to Autism
A cross-trait meta-analysis of genome-wide association studies on schizophrenia (65,967 cases), bipolar disorder (41,653 cases), autism spectrum disorder (46,350 cases), ADHD (55,374 cases) and depression (688,809 cases) identified an intronic SNP in the SORCS3 gene that reached genome-wide significance for ASD following MTAG analysis (P-value 6.26E-09) (Wu et al., 2020). Other SNPs in this gene have previously been shown to reach genome-wide significance for association with ADHD (Demontis et al., 2018) and depression (Wray et al., 2018; Howard et al., 2019). A de novo nonsense variant in SORCS3 was identified in an ASD proband from the Autism Sequencing Consortium (De Rubeis et al., 2014), and a homozygous missense variant in this gene was identified in two deceased brothers born to consanguineous parents who had presented with global developmental delay, intellectual disability, infantile spasms, microcephaly, and hypotonia (Alfadhel et al., 2018).
Molecular Function
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing.
External Links
SFARI Genomic Platforms
Reports related to SORCS3 (7 Reports)
# | Type | Title | Author, Year | Autism Report | Associated Disorders |
---|---|---|---|---|---|
1 | Support | Synaptic, transcriptional and chromatin genes disrupted in autism | De Rubeis S , et al. (2014) | Yes | - |
2 | Positive Association | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Wray NR , et al. (2018) | No | - |
3 | Positive Association | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder | Demontis D , et al. (2018) | No | - |
4 | Support | The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability | Alfadhel M et al. (2018) | No | - |
5 | Positive Association | Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions | Howard DM et al. (2019) | No | - |
6 | Primary | Multi-trait analysis for genome-wide association study of five psychiatric disorders | Wu Y et al. (2020) | Yes | - |
7 | Positive Association | - | Yi Yang et al. () | Yes | - |
Rare Variants (2)
Status | Allele Change | Residue Change | Variant Type | Inheritance Pattern | Parental Transmission | Family Type | PubMed ID | Author, Year |
---|---|---|---|---|---|---|---|---|
c.2938C>T | p.Gln980Ter | stop_gained | De novo | - | - | 25363760 | De Rubeis S , et al. (2014) | |
c.3110C>G | p.Thr1037Ser | missense_variant | Familial | Both parents | Multiplex | 30586538 | Alfadhel M et al. (2018) |
Common Variants (5)
Status | Allele Change | Residue Change | Variant Type | Inheritance Pattern | Paternal Transmission | Family Type | PubMed ID | Author, Year |
---|---|---|---|---|---|---|---|---|
- | - | intron_variant | - | - | - | 38821058 | Yi Yang et al. () | |
c.954+7853T>G | - | intron_variant | - | - | - | 32606422 | Wu Y et al. (2020) | |
c.628-38626C>T | - | intron_variant | - | - | - | 29700475 | Wray NR , et al. (2018) | |
c.695+8222A>G | - | intron_variant | - | - | - | 30718901 | Howard DM et al. (2019) | |
c.954+10103T>A | - | intron_variant | - | - | - | 30478444 | Demontis D , et al. (2018) |
SFARI Gene score
Strong Candidate
![](https://gene.sfari.org//wp-content/themes/sfari-gene/img/color-band/2.png)
![](https://gene.sfari.org//wp-content/themes/sfari-gene/img/color-band/s-null.png)
Score Delta: Score remained at 2
criteria met
See SFARI Gene'scoring criteriaWe considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.
4/1/2022
![icon](https://gene.sfari.org//wp-content/themes/sfari-gene/img/score-up.png)
Increased from to 2
Krishnan Probability Score
Score 0.6033041800115
Ranking 366/25841 scored genes
[Show Scoring Methodology]
ExAC Score
Score 0.32513426350828
Ranking 6369/18225 scored genes
[Show Scoring Methodology]
Sanders TADA Score
Score 0.51179727631057
Ranking 474/18665 scored genes
[Show Scoring Methodology]
Zhang D Score
Score 0.20872764826425
Ranking 4137/20870 scored genes
[Show Scoring Methodology]