Human Gene Module / Chromosome 14 / CHD8

CHD8chromodomain helicase DNA binding protein 8

SFARI Gene Score
1S
High Confidence, Syndromic Criteria 1.1, Syndromic
Autism Reports / Total Reports
79 / 121
Rare Variants / Common Variants
319 / 0
EAGLE Score
97.65
Strong Learn More
Aliases
CHD8, HELSNF1
Associated Syndromes
-
Chromosome Band
14q11.2
Associated Disorders
SCZ, DD/NDD, ADHD, ID, EPS, ASD
Genetic Category
Rare Single Gene Mutation, Syndromic, Functional
Relevance to Autism

Recurrent mutations in the CHD8 gene have been identified in multiple individuals with ASD as described below. O'Roak et al., 2012a reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families (PMID 22495309). In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, O'Roak et al., 2012b identified 6 additional de novo CHD8 LoF mutations (PMID 23160995). A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in Iossifov et al., 2014 (PMID 25363768). Talkowski et al., 2012 (PMID 22521361) showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) in De Rubeis et al., 2014 identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017). Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in Bernier et al., 2014 (PMID 24998929); a phenotypic comparison of patients with CHD8 variants in this report identified recurrent phenotypes and dysmorphic facial features suggestive of a syndromic form of ASD. A two-stage analysis of rare de novo and inherited coding variants in 42,607 ASD cases, including 35,130 new cases from the SPARK cohort, in Zhou et al., 2022 identified CHD8 as a gene reaching exome-wide significance (P < 2.5E-06).

Molecular Function

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

SFARI Genomic Platforms
Reports related to CHD8 (121 Reports)
# Type Title Author, Year Autism Report Associated Disorders
1 Support Novel deletions of 14q11.2 associated with developmental delay, cognitive impairment and similar minor anomalies in three children Zahir F , et al. (2007) No Cognitive impairment
2 Support CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome Batsukh T , et al. (2010) No -
3 Primary Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations O'Roak BJ , et al. (2012) Yes -
4 Support Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries Talkowski ME , et al. (2012) Yes -
5 Support Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders O'Roak BJ , et al. (2012) Yes -
6 Support De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability McCarthy SE , et al. (2014) No -
7 Recent Recommendation Disruptive CHD8 mutations define a subtype of autism early in development Bernier R , et al. (2014) Yes DD, ID
8 Support Recurrent ?100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly Prontera P , et al. (2014) Yes -
9 Recent Recommendation CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors Sugathan A , et al. (2014) No -
10 Recent Recommendation Synaptic, transcriptional and chromatin genes disrupted in autism De Rubeis S , et al. (2014) Yes -
11 Support The contribution of de novo coding mutations to autism spectrum disorder Iossifov I et al. (2014) Yes -
12 Support Recurrent de novo mutations implicate novel genes underlying simplex autism risk O'Roak BJ , et al. (2014) Yes -
13 Support Large-scale discovery of novel genetic causes of developmental disorders Deciphering Developmental Disorders Study (2014) Yes -
14 Recent Recommendation The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment Cotney J , et al. (2015) No -
15 Recent Recommendation The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes Wilkinson B , et al. (2015) No -
16 Recent Recommendation Low load for disruptive mutations in autism genes and their biased transmission Iossifov I , et al. (2015) Yes -
17 Support Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci Sanders SJ , et al. (2015) Yes -
18 Support Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms D'Gama AM , et al. (2015) Yes -
19 Support A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review Merner N , et al. (2016) Yes ID, SCZ
20 Support Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay Smyk M , et al. (2016) No -
21 Support CHD8 intragenic deletion associated with autism spectrum disorder Stolerman ES , et al. (2016) Yes -
22 Support Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility Kimura H et al. (2016) No DD, ID, autistic features, stereotypy
23 Recent Recommendation Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling Durak O , et al. (2016) No -
24 Support De novo genic mutations among a Chinese autism spectrum disorder cohort Wang T , et al. (2016) Yes -
25 Support The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies Redin C , et al. (2016) Yes -
26 Support Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases Stessman HA , et al. (2017) Yes -
27 Support Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder C Yuen RK et al. (2017) Yes -
28 Support Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism Chen R , et al. (2017) Yes -
29 Support Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability Tatton-Brown K , et al. (2017) No Macrocephaly, tall stature
30 Support Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder Lim ET , et al. (2017) Yes -
31 Support Targeted sequencing and functional analysis reveal brain-size-related genes and their networks in autism spectrum disorders Li J , et al. (2017) Yes -
32 Support Exome Pool-Seq in neurodevelopmental disorders Popp B , et al. (2017) No Autistic featues (social difficulties)
33 Recent Recommendation Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice Jung H , et al. (2018) No -
34 Support The autism spectrum phenotype in ADNP syndrome Arnett AB , et al. (2018) Yes ID
35 Support Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8 Marie C , et al. (2018) No -
36 Support Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes Kasah S , et al. (2018) No -
37 Support Autism spectrum disorder early in development associated with CHD8 mutations among two Chinese children Wang J , et al. (2018) Yes -
38 Support Genomic landscapes of Chinese sporadic autism spectrum disorders revealed by whole-genome sequencing Wu J , et al. (2018) Yes -
39 Support Diagnostic approach with genetic tests for global developmental delay and/or intellectual disability: Single tertiary center experience Han JY et al. (2019) No -
40 Support Genetic Diagnostic Evaluation of Trio-Based Whole Exome Sequencing Among Children With Diagnosed or Suspected Autism Spectrum Disorder Du X , et al. (2018) Yes DD/ID
41 Support Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model Guo H , et al. (2018) Yes -
42 Support Targeted Next-Generation Sequencing of Korean Patients With Developmental Delay and/or Intellectual Disability Han JY , et al. (2019) No ADHD
43 Support A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8 Yasin H , et al. (2019) Yes -
44 Support The clinical presentation caused by truncating CHD8 variants Douzgou S , et al. (2019) Yes Macrocephaly
45 Support Neurological Diseases With Autism Spectrum Disorder: Role of ASD Risk Genes Xiong J , et al. (2019) Yes ID
46 Support Whole genome sequencing and variant discovery in the ASPIRE autism spectrum disorder cohort Callaghan DB , et al. (2019) Yes -
47 Support Lessons Learned from Large-Scale, First-Tier Clinical Exome Sequencing in a Highly Consanguineous Population Monies D , et al. (2019) Yes ID, epilepsy/seizures
48 Support Characterization of intellectual disability and autism comorbidity through gene panel sequencing Aspromonte MC , et al. (2019) Yes -
49 Support Autism-associated missense genetic variants impact locomotion and neurodevelopment in Caenorhabditis elegans Wong WR , et al. (2019) Yes -
50 Support Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks Ruzzo EK , et al. (2019) Yes -
51 Support Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes Feliciano P et al. (2019) Yes -
52 Support The CHD8 overgrowth syndrome: A detailed evaluation of an emerging overgrowth phenotype in 27 patients Ostrowski PJ , et al. (2019) No ASD, overgrowth
53 Support Genetic investigation of patients with tall stature Vasco de Albuquerque Albuquerque E et al. (2020) No Tall stature, macrocephaly
54 Support De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism Cappi C , et al. (2019) No -
55 Support De novo variants in the Helicase-C domain of CHD8 are associated with severe phenotypes including autism, language disability and overgrowth An Y , et al. (2020) Yes -
56 Support Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism Satterstrom FK et al. (2020) Yes -
57 Support Rare genetic susceptibility variants assessment in autism spectrum disorder: detection rate and practical use Husson T , et al. (2020) Yes -
58 Support Genetic landscape of autism spectrum disorder in Vietnamese children Tran KT et al. (2020) Yes -
59 Support Excess of de novo variants in genes involved in chromatin remodelling in patients with marfanoid habitus and intellectual disability Chevarin M et al. (2020) No Marfanoid habitus
60 Support A de novo variant of CHD8 in a patient with autism spectrum disorder Alotaibi M et al. (2020) No Autistic behavior, stereotypy
61 Support Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders Wang T et al. (2020) Yes -
62 Support - Jiménez JA et al. (2020) Yes -
63 Recent recommendation - Sadler B et al. (2021) No ASD, DD
64 Support - Rodin RE et al. (2021) Yes -
65 Support - Brunet T et al. (2021) Yes -
66 Support - Kawamura A et al. (2021) Yes -
67 Support - Ellingford RA et al. (2021) Yes -
68 Recent Recommendation - Coll-Tané M et al. (2021) No -
69 Support - Doummar D et al. (2021) No ASD, ID
70 Support - Takanezawa Y et al. (2021) No -
71 Support - Mahjani B et al. (2021) Yes -
72 Recent Recommendation - Paulsen B et al. (2022) Yes -
73 Support - Chen X et al. (2022) No -
74 Support - Yu Y et al. (2022) Yes -
75 Support - Villa CE et al. (2022) Yes -
76 Support - Chuan Z et al. (2022) No ID
77 Support - Hu C et al. (2022) Yes -
78 Support - Krgovic D et al. (2022) Yes DD
79 Support - Tu Z et al. (2022) No -
80 Support - Zhou X et al. (2022) Yes ADHD
81 Support - Dong C et al. (2022) No -
82 Recent Recommendation - Dingemans AJM et al. (2022) Yes ID, epilepsy/seizures, stereotypy
83 Support - Coakley-Youngs E et al. (2022) Yes -
84 Support - Hayot G et al. (2022) No -
85 Support - Lee SY et al. (2022) Yes -
86 Support - Shimelis H et al. (2023) No Epilepsy/seizures
87 Support - Kerschbamer E et al. (2022) No -
88 Support - Haddad Derafshi B et al. (2022) No -
89 Support - Kim C et al. (2023) Yes -
90 Recent Recommendation - Tabbaa M et al. (2023) Yes -
91 Support - Lee SY et al. (2023) Yes -
92 Support - Li B et al. (2023) Yes -
93 Recent Recommendation - Weinschutz Mendes H et al. (2023) Yes -
94 Support - Hu C et al. (2023) Yes -
95 Recent Recommendation - Munz M et al. (2023) Yes -
96 Support - Kawamura A et al. (2023) No -
97 Support - Wang J et al. (2023) Yes -
98 Recent Recommendation - Ipsita Chatterjee et al. (2023) Yes -
99 Support - Amerh S Alqahtani et al. (2023) Yes -
100 Recent Recommendation - Xi Shi et al. (2023) Yes -
101 Support - Erica Rosina et al. (2024) Yes -
102 Support - Marketa Wayhelova et al. (2024) No -
103 Support - Tamam Khalaf et al. (2024) Yes -
104 Recent Recommendation - Taichi Shiraishi et al. () Yes -
105 Support - Ugo Sorrentino et al. (2024) No DD, ID
106 Support - Emily L Hendricks et al. (2024) No -
107 Support - Robert A Ellingford et al. (2024) Yes -
108 Support - Manal Tabbaa et al. (2024) Yes -
109 Support - Emily Neuhaus et al. (2024) Yes Anxiety
110 Support - Ruohao Wu et al. (2024) Yes -
111 Support - Angelo Niosi et al. () No -
112 Support - Axel Schmidt et al. (2024) No Cognitive impairment
113 Support - Suhua Chang et al. () Yes -
114 Support - Karen Lob et al. () Yes DD
115 Support - Maider Astorkia et al. (2024) Yes -
116 Support - Soo-Whee Kim et al. (2024) Yes -
117 Support - Hosneara Akter et al. () No -
118 Support - Guihua Lai et al. (2024) No Autistic behavior
119 Support - Jesper Eisfeldt et al. (2024) Yes -
120 Support - Chengyan Li et al. (2024) No -
121 Support - Mariia A Parfenenko et al. (2024) Yes ADHD, ID, epilepsy/seizures
Rare Variants   (319)
Status Allele Change Residue Change Variant Type Inheritance Pattern Parental Transmission Family Type PubMed ID Author, Year
- - translocation De novo - - 27841880 Redin C , et al. (2016)
- - copy_number_loss De novo - - 30670789 Yasin H , et al. (2019)
- - translocation De novo - - 22521361 Talkowski ME , et al. (2012)
- - copy_number_loss De novo - - 25257502 Prontera P , et al. (2014)
- - copy_number_gain De novo - Simplex 26834018 Smyk M , et al. (2016)
- - copy_number_loss De novo - Simplex 17545556 Zahir F , et al. (2007)
- - copy_number_gain Unknown - Unknown 24998929 Bernier R , et al. (2014)
c.142C>T p.Gln48Ter stop_gained De novo - - 35982159 Zhou X et al. (2022)
c.464C>G p.Ser155Ter stop_gained De novo - - 33004838 Wang T et al. (2020)
c.727C>T p.Arg243Ter stop_gained Unknown - - 33004838 Wang T et al. (2020)
c.529C>T p.Gln177Ter stop_gained De novo - - 35982159 Zhou X et al. (2022)
c.2226+2T>C - splice_site_variant Unknown - - 33004838 Wang T et al. (2020)
c.2486+1G>A - splice_site_variant De novo - - 33004838 Wang T et al. (2020)
c.2730+1G>A - splice_site_variant Unknown - - 33004838 Wang T et al. (2020)
c.3307+1G>A - splice_site_variant De novo - - 33004838 Wang T et al. (2020)
c.3882+1G>A - splice_site_variant De novo - - 33004838 Wang T et al. (2020)
c.4817+1G>A - splice_site_variant Unknown - - 35982159 Zhou X et al. (2022)
c.5127+1G>A - splice_site_variant De novo - - 35982159 Zhou X et al. (2022)
c.4210C>T p.Gln1404Ter stop_gained De novo - - 39136901 Karen Lob et al. ()
c.2854C>T p.Arg952Ter stop_gained De novo - - 33004838 Wang T et al. (2020)
c.1444C>T p.Arg482Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.1744C>T p.Arg582Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.2157dup p.Asn720Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.2643G>A p.Trp881Ter stop_gained De novo - - 35982159 Zhou X et al. (2022)
c.1716+9A>T - intron_variant Familial Maternal - 37007974 Hu C et al. (2023)
c.4204C>T p.Arg1402Ter stop_gained Unknown - - 33004838 Wang T et al. (2020)
c.5179G>T p.Glu1727Ter stop_gained Unknown - - 33004838 Wang T et al. (2020)
c.5389C>T p.Arg1797Ter stop_gained De novo - - 33004838 Wang T et al. (2020)
c.6103C>T p.Arg2035Ter stop_gained De novo - - 33004838 Wang T et al. (2020)
c.6649C>T p.Arg2217Ter stop_gained Unknown - - 33004838 Wang T et al. (2020)
c.4009C>T p.Arg1337Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.4665T>G p.Tyr1555Ter stop_gained De novo - - 35982159 Zhou X et al. (2022)
c.4799T>G p.Leu1600Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.5389C>T p.Arg1797Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.6649C>T p.Arg2217Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.7054C>T p.Arg2352Ter stop_gained Unknown - - 35982159 Zhou X et al. (2022)
c.7087C>T p.Gln2363Ter stop_gained De novo - - 35982159 Zhou X et al. (2022)
c.1601+6T>G - splice_region_variant De novo - - 35982159 Zhou X et al. (2022)
- - copy_number_loss De novo - Multiplex 26921529 Stolerman ES , et al. (2016)
c.3882+1G>A - splice_site_variant De novo - - 30107084 Arnett AB , et al. (2018)
c.1899+1G>T - splice_site_variant De novo - - 31001818 Douzgou S , et al. (2019)
c.3518+1G>T - splice_site_variant De novo - - 31001818 Douzgou S , et al. (2019)
c.7183-1G>A - splice_site_variant Unknown - - 36475376 Shimelis H et al. (2023)
c.2072A>G p.Asp691Gly missense_variant De novo - - 28831199 Li J , et al. (2017)
c.2854C>T p.Arg952Ter stop_gained De novo - - 30107084 Arnett AB , et al. (2018)
c.2059C>T p.Gln687Ter stop_gained De novo - - 31001818 Douzgou S , et al. (2019)
c.2706del p.Tyr902Ter stop_gained Unknown - - 31001818 Douzgou S , et al. (2019)
c.706C>T p.Gln236Ter stop_gained De novo - - 31452935 Feliciano P et al. (2019)
c.6857A>G p.Lys2286Arg missense_variant Unknown - - 31980904 An Y , et al. (2020)
c.4818-1G>A - splice_site_variant De novo - Simplex 31980904 An Y , et al. (2020)
c.1477C>T p.Arg493Trp missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.1504C>T p.Arg502Cys missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.2854C>G p.Arg952Gly missense_variant De novo - - 33004838 Wang T et al. (2020)
c.2855G>A p.Arg952Gln missense_variant De novo - - 33004838 Wang T et al. (2020)
c.2972T>A p.Leu991His missense_variant De novo - - 33004838 Wang T et al. (2020)
c.1745G>A p.Arg582Gln missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.3340G>T p.Glu1114Ter stop_gained De novo - - 24998929 Bernier R , et al. (2014)
c.4204C>T p.Arg1402Ter stop_gained De novo - - 30107084 Arnett AB , et al. (2018)
c.5179G>T p.Glu1727Ter stop_gained De novo - - 30107084 Arnett AB , et al. (2018)
c.3617T>G p.Leu1206Ter stop_gained De novo - - 31001818 Douzgou S , et al. (2019)
c.3724C>T p.Arg1242Ter stop_gained De novo - - 31001818 Douzgou S , et al. (2019)
c.5017C>T p.Arg1673Ter stop_gained Unknown - - 36475376 Shimelis H et al. (2023)
c.2065G>T p.Glu689Ter stop_gained De novo - Simplex 31980904 An Y , et al. (2020)
c.2854C>T p.Arg952Ter stop_gained De novo - Simplex 36731504 Kim C et al. (2023)
c.5488C>T p.Arg1830Cys missense_variant De novo - - 30402882 Han JY et al. (2019)
c.4405C>T p.Arg1469Cys missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.4484G>A p.Arg1495His missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5077G>T p.Asp1693Tyr missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5222C>T p.Pro1741Leu missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5314C>T p.Arg1772Cys missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5483G>A p.Arg1828His missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5575C>T p.Arg1859Cys missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5665C>T p.Arg1889Cys missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5684G>A p.Arg1895His missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.5816G>A p.Arg1939His missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.7000C>T p.Arg2334Trp missense_variant Unknown - - 33004838 Wang T et al. (2020)
c.4658G>A p.Arg1553Gln missense_variant De novo - - 35982159 Zhou X et al. (2022)
c.634C>T p.Arg212Ter stop_gained De novo - Simplex 30564305 Guo H , et al. (2018)
c.5051+2T>A - splice_site_variant De novo - Simplex 33004838 Wang T et al. (2020)
c.1096C>T p.Gln366Ter stop_gained De novo - - 28191889 Stessman HA , et al. (2017)
c.751C>T p.Gln251Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.3518+5G>C - splice_site_variant De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.5599+2T>C - splice_site_variant Unknown - - 31721432 Ostrowski PJ , et al. (2019)
c.2731-2A>G - splice_site_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4062+5G>C - splice_site_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.3562C>T p.Arg1188Ter stop_gained De novo - Simplex 31980904 An Y , et al. (2020)
c.5488C>T p.Arg1830Cys missense_variant De novo - - 30631761 Han JY , et al. (2019)
c.5275A>C p.Ser1759Arg missense_variant Unknown - - 35571021 Chuan Z et al. (2022)
c.2230G>A p.Val744Ile missense_variant De novo - - 33432195 Rodin RE et al. (2021)
c.4871G>A p.Trp1624Ter stop_gained Unknown - - 38438125 Tamam Khalaf et al. (2024)
c.5690G>A p.Trp1897Ter stop_gained De novo - - 39039281 Axel Schmidt et al. (2024)
c.6730C>T p.Arg2244Ter stop_gained De novo - - 39039281 Axel Schmidt et al. (2024)
c.1690C>T p.Arg564Ter stop_gained De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.2140G>T p.Glu714Ter stop_gained De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.1744C>T p.Arg582Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4062+5G>C - splice_site_variant Unknown - - 34088660 Coll-Tané M et al. (2021)
c.5769G>A p.Trp1923Ter stop_gained De novo - Simplex 35982159 Zhou X et al. (2022)
c.2647G>T p.Glu883Ter stop_gained De novo - Simplex 30376831 Wang J , et al. (2018)
c.4571-1G>A - splice_site_variant De novo - Simplex 31771860 Cappi C , et al. (2019)
c.2907+1G>T - splice_site_variant De novo - Simplex 33352116 Sadler B et al. (2021)
c.2182A>G p.Arg728Gly missense_variant Unknown - - 34615535 Mahjani B et al. (2021)
c.2024+5G>A p.? splice_site_variant De novo - - 39334436 Soo-Whee Kim et al. (2024)
c.3562C>T p.Arg1188Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4009C>T p.Arg1337Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4131G>A p.Trp1377Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4204C>T p.Arg1402Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4984C>T p.Arg1662Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.5017C>T p.Arg1673Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.5771G>A p.Trp1924Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.5892T>G p.Tyr1964Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.6649C>T p.Arg2217Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.7054C>T p.Arg2352Ter stop_gained Unknown - - 36182950 Dingemans AJM et al. (2022)
c.1601+6T>A - splice_region_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.2024+5G>A - splice_site_variant De novo - - 28475857 Tatton-Brown K , et al. (2017)
c.5051+1G>C - splice_site_variant Unknown - - 28475857 Tatton-Brown K , et al. (2017)
c.6085G>A p.Glu2029Lys missense_variant Unknown - - 26789910 Merner N , et al. (2016)
c.6538C>T p.Arg2180Cys missense_variant Unknown - - 26789910 Merner N , et al. (2016)
c.6830G>C p.Gly2277Ala missense_variant Unknown - - 26789910 Merner N , et al. (2016)
c.3650A>G p.Asn1217Ser missense_variant Unknown - - 34615535 Mahjani B et al. (2021)
c.7181A>G p.Lys2394Arg missense_variant Unknown - - 35813072 Krgovic D et al. (2022)
c.7620C>T p.Asp2540= synonymous_variant Unknown - - 26789910 Merner N , et al. (2016)
c.5051+2T>A - splice_site_variant De novo - Simplex 28263302 C Yuen RK et al. (2017)
c.2562_2563del p.Tyr854Ter stop_gained De novo - - 31001818 Douzgou S , et al. (2019)
c.2317G>A p.Glu773Lys missense_variant Unknown - - 39342494 Hosneara Akter et al. ()
- p.Glu1932SerfsTer3 frameshift_variant De novo - - 24998929 Bernier R , et al. (2014)
- p.Glu2136ArgfsTer6 frameshift_variant De novo - - 24998929 Bernier R , et al. (2014)
c.185C>G p.Ser62Ter stop_gained De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.3724C>T p.Arg1242Ter stop_gained De novo - Multiplex 35982159 Zhou X et al. (2022)
c.4414C>T p.Arg1472Ter stop_gained De novo - Simplex 33352116 Sadler B et al. (2021)
c.4515G>A p.Trp1505Ter stop_gained De novo - Simplex 33352116 Sadler B et al. (2021)
c.4378C>T p.Arg1460Ter stop_gained De novo - Unknown 33619735 Brunet T et al. (2021)
c.4818-2A>C - splice_site_variant Familial - Simplex 28263302 C Yuen RK et al. (2017)
c.4259_4260del p.Ser1420Ter stop_gained De novo - - 31001818 Douzgou S , et al. (2019)
c.3519-2A>G - splice_site_variant De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.1599C>G p.Leu533= synonymous_variant De novo - - 31452935 Feliciano P et al. (2019)
c.4062+42C>T - intron_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.4204C>T p.Arg1402Ter stop_gained Unknown - - 28475857 Tatton-Brown K , et al. (2017)
c.4414C>T p.Arg1472Ter stop_gained De novo - - 28475857 Tatton-Brown K , et al. (2017)
- - copy_number_gain Familial Paternal Simplex 39472019 Jesper Eisfeldt et al. (2024)
c.4984C>T p.Arg1662Ter stop_gained De novo - Simplex 31130284 Monies D , et al. (2019)
c.1601+38del - splice_site_variant De novo - Simplex 25363768 Iossifov I et al. (2014)
c.3312del p.Glu1105LysfsTer5 frameshift_variant De novo - - 35741772 Hu C et al. (2022)
c.3502T>A p.Tyr1168Asn missense_variant De novo - Simplex 31980904 An Y , et al. (2020)
c.837dup p.Thr280TyrfsTer4 frameshift_variant Unknown - - 33004838 Wang T et al. (2020)
c.2711T>G p.Met904Arg missense_variant De novo - Simplex 30564305 Guo H , et al. (2018)
c.1733G>A p.Arg578His missense_variant Unknown - Simplex 33004838 Wang T et al. (2020)
c.7182+3dup - splice_site_variant Familial - Multiplex 28263302 C Yuen RK et al. (2017)
c.3712C>T p.Gln1238Ter stop_gained De novo - Simplex 22495309 O'Roak BJ , et al. (2012)
c.4009C>T p.Arg1337Ter stop_gained De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.5500C>T p.Arg1834Ter stop_gained De novo - Simplex 25418537 O'Roak BJ , et al. (2014)
c.4984C>T p.Arg1662Ter stop_gained De novo - Simplex 32309624 Alotaibi M et al. (2020)
c.2868dup p.Asn957Ter stop_gained De novo - Simplex 39528574 Chengyan Li et al. (2024)
c.5690G>A p.Arg1897Gln missense_variant De novo - - 39334436 Soo-Whee Kim et al. (2024)
c.4818-2A>C - splice_site_variant De novo - Simplex 25363760 De Rubeis S , et al. (2014)
c.5051+2T>A - splice_site_variant De novo - Simplex 25363760 De Rubeis S , et al. (2014)
c.2617A>G p.Asn873Asp missense_variant De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.2927C>A p.Thr976Lys missense_variant De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.1928T>G p.Ile643Ser missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.2252G>T p.Trp751Leu missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.2522G>A p.Gly841Asp missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.3338G>A p.Arg1113His missense_variant Familial Maternal - 37007974 Hu C et al. (2023)
c.2345del p.His782ProfsTer7 frameshift_variant De novo - - 33004838 Wang T et al. (2020)
c.6122_6123del p.Tyr2041Ter frameshift_variant De novo - - 33004838 Wang T et al. (2020)
c.3274C>T p.Arg1092Cys missense_variant De novo - Simplex 35982159 Zhou X et al. (2022)
c.3518G>A p.Arg1173Lys missense_variant De novo - Simplex 35982159 Zhou X et al. (2022)
c.4523T>G p.Ile1508Ser missense_variant De novo - Simplex 35982159 Zhou X et al. (2022)
c.4738C>T p.Arg1580Trp missense_variant De novo - Simplex 35982159 Zhou X et al. (2022)
c.2514G>T p.Met838Ile missense_variant De novo - Simplex 30376831 Wang J , et al. (2018)
c.3665A>T p.Asp1222Val missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.3922A>G p.Arg1308Gly missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.3964G>C p.Gly1322Arg missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4523T>G p.Ile1508Ser missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4895C>T p.Ser1632Leu missense_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.2104A>G p.Lys702Glu missense_variant Unknown - - 31209962 Aspromonte MC , et al. (2019)
c.7085A>G p.Lys2362Arg missense_variant Familial Paternal - 31980904 An Y , et al. (2020)
c.7310G>A p.Ser2437Asn missense_variant Familial Maternal - 31980904 An Y , et al. (2020)
c.2477G>T p.Trp826Leu missense_variant Familial Maternal - 33004838 Wang T et al. (2020)
c.2812C>T p.Arg938Cys missense_variant Familial Maternal - 33004838 Wang T et al. (2020)
c.1494del p.Glu499ArgfsTer13 frameshift_variant Unknown - - 33004838 Wang T et al. (2020)
c.1869del p.Glu624ArgfsTer21 frameshift_variant De novo - - 33004838 Wang T et al. (2020)
c.6404dup p.Glu2136ArgfsTer6 frameshift_variant Unknown - - 33004838 Wang T et al. (2020)
c.347del p.Thr116AsnfsTer14 frameshift_variant De novo - - 29158550 Popp B , et al. (2017)
c.3284G>A p.Cys1095Tyr missense_variant De novo - Simplex 28344757 Chen R , et al. (2017)
c.3790G>A p.Glu1264Lys missense_variant De novo - Simplex 28714951 Lim ET , et al. (2017)
c.3575T>C p.Ile1192Thr missense_variant De novo - Simplex 32193494 Tran KT et al. (2020)
c.6518C>A p.Ser2173Ter stop_gained De novo - Simplex 24776741 McCarthy SE , et al. (2014)
c.5393G>A p.Trp1798Ter stop_gained Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.5422C>T p.Arg1808Ter stop_gained De novo - Simplex 38041506 Erica Rosina et al. (2024)
c.2025-1G>T - splice_site_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.5371C>T p.Arg1791Trp missense_variant Familial Paternal - 33004838 Wang T et al. (2020)
c.5390G>T p.Arg1797Leu missense_variant Familial Maternal - 33004838 Wang T et al. (2020)
c.6473G>A p.Arg2158His missense_variant Familial Paternal - 33004838 Wang T et al. (2020)
c.5063del p.Asp1688ValfsTer26 frameshift_variant Unknown - - 35982159 Zhou X et al. (2022)
c.6984del p.Glu2329ArgfsTer26 frameshift_variant Unknown - - 35982159 Zhou X et al. (2022)
c.2250del p.Lys750AsnfsTer14 frameshift_variant De novo - - 27824329 Wang T , et al. (2016)
c.6997C>T p.Arg2333Cys missense_variant Unknown - Simplex 27595554 Kimura H et al. (2016)
c.3979G>A p.Glu1327Lys missense_variant De novo - Simplex 31771860 Cappi C , et al. (2019)
c.1807G>A p.Asp603Asn missense_variant Unknown - Unknown 31130284 Monies D , et al. (2019)
c.6859_6861del p.Lys2287del inframe_deletion Unknown - - 24998929 Bernier R , et al. (2014)
c.635G>A p.Arg212Gln missense_variant De novo - Simplex 25418537 O'Roak BJ , et al. (2014)
c.4367A>G p.Tyr1456Cys missense_variant Unknown - - 28475857 Tatton-Brown K , et al. (2017)
c.5288A>G p.Glu1763Gly missense_variant Familial Paternal - 27824329 Wang T , et al. (2016)
c.3704del p.Asn1235MetfsTer18 frameshift_variant De novo - - 27824329 Wang T , et al. (2016)
c.5688dup p.Arg1897ThrfsTer23 frameshift_variant De novo - - 27824329 Wang T , et al. (2016)
c.856C>T p.Arg286Cys missense_variant Familial Paternal - 26789910 Merner N , et al. (2016)
c.7287G>A p.Met2429Ile missense_variant Unknown - Simplex 31130284 Monies D , et al. (2019)
c.2729G>A p.Arg910Gln missense_variant Unknown - Unknown 24998929 Bernier R , et al. (2014)
c.2086C>A p.Gln696Lys missense_variant De novo - Simplex 25418537 O'Roak BJ , et al. (2014)
c.2712G>A p.Met904Ile missense_variant De novo - Simplex 25418537 O'Roak BJ , et al. (2014)
c.2230G>A p.Val744Ile missense_variant Unknown - Unknown 26637798 D'Gama AM , et al. (2015)
- - copy_number_gain Familial Paternal Possible multiplex 24998929 Bernier R , et al. (2014)
c.5803A>T p.Arg1935Ter stop_gained Familial Maternal Simplex 30564305 Guo H , et al. (2018)
c.3879T>A p.Thr1293%3D synonymous_variant De novo - Multiplex 35982159 Zhou X et al. (2022)
c.1323G>C p.Gly441= synonymous_variant Familial Paternal - 26789910 Merner N , et al. (2016)
c.2345del p.His782ProfsTer7 frameshift_variant De novo - - 30107084 Arnett AB , et al. (2018)
c.1423dup p.Arg475ProfsTer3 frameshift_variant Unknown - - 36475376 Shimelis H et al. (2023)
c.4738C>T p.Arg1580Trp missense_variant De novo - Simplex 25418537 O'Roak BJ , et al. (2014)
c.410G>T p.Gly137Val missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.494C>T p.Pro165Leu missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.4811T>C p.Ile1604Thr missense_variant Familial Maternal - 26789910 Merner N , et al. (2016)
c.6472C>T p.Arg2158Cys missense_variant Familial Maternal - 26789910 Merner N , et al. (2016)
c.4752A>G p.Leu1584= synonymous_variant Familial Maternal - 26789910 Merner N , et al. (2016)
c.5916A>G p.Ala1972= synonymous_variant Familial Maternal - 26789910 Merner N , et al. (2016)
c.6312G>A p.Glu2104= synonymous_variant Familial Paternal - 26789910 Merner N , et al. (2016)
c.6804C>T p.His2268= synonymous_variant Familial Paternal - 26789910 Merner N , et al. (2016)
c.2420del p.Asn807ThrfsTer78 frameshift_variant De novo - - 30107084 Arnett AB , et al. (2018)
c.3322dup p.Ile1108AsnfsTer7 frameshift_variant De novo - - 30107084 Arnett AB , et al. (2018)
c.1635del p.Lys545AsnfsTer47 frameshift_variant Unknown - - 31001818 Douzgou S , et al. (2019)
c.2240dup p.Tyr747Ter frameshift_variant De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.2501T>C p.Leu834Pro missense_variant De novo - Simplex 25363760 De Rubeis S , et al. (2014)
c.1733G>A p.Arg578His missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.5129G>T p.Gly1710Val missense_variant Familial Maternal - 24998929 Bernier R , et al. (2014)
c.3322dup p.Ile1108AsnfsTer7 frameshift_variant De novo - - 31452935 Feliciano P et al. (2019)
c.2613dup p.Thr872TyrfsTer2 frameshift_variant De novo - - 39334436 Soo-Whee Kim et al. (2024)
c.3725G>A p.Arg1242Gln missense_variant De novo - Simplex 25363760 De Rubeis S , et al. (2014)
c.3214C>T p.Leu1072Phe missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.5665C>T p.Arg1889Cys missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.5683C>T p.Arg1895Cys missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.5936G>A p.Arg1979His missense_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.2734C>T p.Arg912Cys missense_variant Unknown - Simplex 31038196 Callaghan DB , et al. (2019)
c.4744C>T p.Arg1582Ter stop_gained Unknown - Unknown 37799141 Amerh S Alqahtani et al. (2023)
c.2318G>A p.Arg773Gln missense_variant Familial Maternal Simplex 31980904 An Y , et al. (2020)
c.4611dup p.Val1538SerfsTer8 frameshift_variant De novo - Simplex 30555518 Du X , et al. (2018)
c.4578_4581del p.Ile1527LeufsTer11 frameshift_variant Unknown - - 33004838 Wang T et al. (2020)
c.3511C>T p.Gln1171Ter stop_gained Familial Paternal Simplex 32094338 Husson T , et al. (2020)
c.3315dup p.Glu1106ArgfsTer9 frameshift_variant De novo - - 28191889 Stessman HA , et al. (2017)
c.58_59del p.Leu20AspfsTer2 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.1733G>A p.Arg578His missense_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.2086C>A p.Gln696Lys missense_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.2712G>A p.Met904Ile missense_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.1716+4908A>C p.? intron_variant Unknown - Simplex 39576488 Mariia A Parfenenko et al. (2024)
c.7562T>C p.Val2521Ala missense_variant Familial Maternal Simplex 31980904 An Y , et al. (2020)
c.5688dup p.Arg1897ThrfsTer23 frameshift_variant De novo - Simplex 28831199 Li J , et al. (2017)
c.4800del p.Gly1602ValfsTer13 frameshift_variant De novo - - 28191889 Stessman HA , et al. (2017)
c.3284G>A p.Cys1095Tyr missense_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.4738C>T p.Arg1580Trp missense_variant De novo - Simplex 31981491 Satterstrom FK et al. (2020)
c.6349G>T p.Glu2117Ter stop_gained Unknown - Simplex 39576488 Mariia A Parfenenko et al. (2024)
c.4800del p.Gly1602ValfsTer13 frameshift_variant De novo - Simplex 30564305 Guo H , et al. (2018)
c.6649C>T p.Arg2217Ter stop_gained Familial Maternal Multiplex 34415117 Doummar D et al. (2021)
c.7493_7495del p.His2498del inframe_deletion De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.5386del p.Gln1796AsnfsTer40 frameshift_variant De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.3050del p.Gln1017ArgfsTer12 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.6270del p.Ser2091ProfsTer16 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.470del p.Pro157LeufsTer50 frameshift_variant De novo - - 28475857 Tatton-Brown K , et al. (2017)
c.2332A>G p.Ile778Val missense_variant Familial Paternal Multiplex 30564305 Guo H , et al. (2018)
c.6359del p.Leu2120ProfsTer19 frameshift_variant De novo - Simplex 39126614 Suhua Chang et al. ()
c.6276dup p.Ser2093LeufsTer4 frameshift_variant De novo - Simplex 26789910 Merner N , et al. (2016)
c.3011_3012del p.Glu1004ValfsTer22 frameshift_variant De novo - - 31001818 Douzgou S , et al. (2019)
c.764_769delinsT p.Gly255fs frameshift_variant De novo - Simplex 39439447 Guihua Lai et al. (2024)
c.517_533del p.Ala173SerfsTer43 frameshift_variant De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.2372C>T p.Pro791Leu missense_variant Unknown Not materal - 31209962 Aspromonte MC , et al. (2019)
c.6115del p.Gln2039LysfsTer37 frameshift_variant Unknown - - 28475857 Tatton-Brown K , et al. (2017)
c.7511dup p.His2504GlnfsTer34 frameshift_variant De novo - - 28475857 Tatton-Brown K , et al. (2017)
c.4342dup p.Arg1448ProfsTer29 frameshift_variant De novo - Simplex 38764027 Ruohao Wu et al. (2024)
c.7112dup p.Asn2371LysfsTer2 frameshift_variant De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.5661_5662del p.Tyr1888ProfsTer31 frameshift_variant De novo - Simplex 28831199 Li J , et al. (2017)
c.5661_5662del p.Tyr1888ProfsTer31 frameshift_variant De novo - Simplex 30392784 Wu J , et al. (2018)
c.6032dup p.Thr2012AspfsTer31 frameshift_variant Familial Maternal - 31031587 Xiong J , et al. (2019)
c.5390G>A p.Arg1797Gln missense_variant Familial Paternal Simplex 24998929 Bernier R , et al. (2014)
c.3338del p.Arg1113LeufsTer41 frameshift_variant De novo - Simplex 32277047 Chevarin M et al. (2020)
c.5513_5519del p.Lys1838MetfsTer51 frameshift_variant De novo - - 39334436 Soo-Whee Kim et al. (2024)
c.4093_4094del p.Asp1365TyrfsTer5 frameshift_variant Unknown - - 31721432 Ostrowski PJ , et al. (2019)
c.5500C>T p.Arg1834Ter stop_gained Familial Maternal Unknown 28475857 Tatton-Brown K , et al. (2017)
c.5654G>A p.Arg1885Gln missense_variant Unknown - Simplex 39576488 Mariia A Parfenenko et al. (2024)
c.6437A>C p.Gln2146Pro missense_variant Unknown - Simplex 39576488 Mariia A Parfenenko et al. (2024)
c.6104G>A p.Arg2035Gln missense_variant Familial Maternal Multiplex 26789910 Merner N , et al. (2016)
c.6148dup p.Thr2050AsnfsTer17 frameshift_variant De novo - Multiplex 28263302 C Yuen RK et al. (2017)
c.1478G>C p.Arg493Pro missense_variant Familial Maternal Simplex 25363760 De Rubeis S , et al. (2014)
c.3532C>T p.Arg1178Cys missense_variant Familial Paternal Simplex 25363760 De Rubeis S , et al. (2014)
c.4913T>G p.Phe1638Cys missense_variant Familial Maternal Simplex 25363760 De Rubeis S , et al. (2014)
c.5666G>A p.Arg1889His missense_variant Familial Paternal Simplex 25363760 De Rubeis S , et al. (2014)
c.4805del p.Gly1602ValfsTer13 frameshift_variant Unknown - Unknown 25363760 De Rubeis S , et al. (2014)
c.7463_7464insTC p.Ser2489ProfsTer24 frameshift_variant De novo - Simplex 37393044 Wang J et al. (2023)
c.1582_1583del p.Lys528GlyfsTer14 frameshift_variant De novo - Simplex 32094338 Husson T , et al. (2020)
c.3528_3529insAA p.Glu1177LysfsTer77 frameshift_variant De novo - - 31721432 Ostrowski PJ , et al. (2019)
c.4744_4745ins16 p.Arg1582LeufsTer31 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.1172dup p.Gln392ThrfsTer29 frameshift_variant De novo - Simplex 38441608 Ugo Sorrentino et al. (2024)
c.3832dup p.Asp1278GlyfsTer2 frameshift_variant Unknown - Simplex 38441608 Ugo Sorrentino et al. (2024)
c.2654del p.Asn885ThrfsTer14 frameshift_variant Familial Paternal Simplex 30564305 Guo H , et al. (2018)
c.6308_6311del p.Glu2103GlyfsTer3 frameshift_variant De novo - Simplex 23160955 O'Roak BJ , et al. (2012)
c.2798_2804delinsTT p.Asp933ValfsTer2 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.1772T>A p.Ile591Lys missense_variant Familial Paternal Multiplex 36182950 Dingemans AJM et al. (2022)
c.1123_1124del p.Leu375ValfsTer45 frameshift_variant De novo - - 38321498 Marketa Wayhelova et al. (2024)
c.6355_6356del p.Leu2120ProfsTer13 frameshift_variant De novo - Simplex 22495309 O'Roak BJ , et al. (2012)
c.3852_3853insTCCA p.Met1285ProfsTer17 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.5796_5797insGCTT p.Leu1933AlafsTer75 frameshift_variant Unknown - - 36182950 Dingemans AJM et al. (2022)
c.4800del p.Gly1602ValfsTer13 frameshift_variant De novo - Multiplex 31981491 Satterstrom FK et al. (2020)
c.2937_2939delinsTC p.Leu980ArgfsTer5 frameshift_variant De novo - Simplex 32094338 Husson T , et al. (2020)
c.3524_3525insC p.Leu1175PhefsTer3 frameshift_variant Unknown - Simplex 38441608 Ugo Sorrentino et al. (2024)
c.1690C>T p.Arg564Ter stop_gained Familial Maternal Multi-generational 28475857 Tatton-Brown K , et al. (2017)
c.6031_6032insT p.Glu2011ValfsTer32 frameshift_variant Familial Maternal Simplex 30564305 Guo H , et al. (2018)
c.4435_4436insGTGGAGACCAT p.Val1479GlyfsTer33 frameshift_variant De novo - Simplex 35982159 Zhou X et al. (2022)
c.4435_4436delinsTA p.Val1479Ter frameshift_variant Familial Maternal Simplex 24998929 Bernier R , et al. (2014)
c.4105_4109del p.Asp1369ProfsTer12 frameshift_variant Unknown - Simplex 39576488 Mariia A Parfenenko et al. (2024)
c.4800_4801del p.Gly1602CysfsTer5 frameshift_variant Unknown Not maternal Simplex 34415117 Doummar D et al. (2021)
c.2154dup p.Phe719LeufsTer2 frameshift_variant Unknown - - 31751304 Vasco de Albuquerque Albuquerque E et al. (2020)
c.7112dup p.Asn2371LysfsTer2 frameshift_variant Familial Maternal Simplex 39576488 Mariia A Parfenenko et al. (2024)
c.3512A>C p.Gln1171Pro missense_variant Familial Paternal Simplex 25533962 Deciphering Developmental Disorders Study (2014)
c.6569_6587del p.Ile2190ThrfsTer3 frameshift_variant Familial Maternal Multi-generational 28475857 Tatton-Brown K , et al. (2017)
Common Variants  

No common variants reported.

SFARI Gene score
1S

High Confidence, Syndromic

Score Delta: Score remained at 1S

1

High Confidence

See all Category 1 Genes

We considered a rigorous statistical comparison between cases and controls, yielding genome-wide statistical significance, with independent replication, to be the strongest possible evidence for a gene. These criteria were relaxed slightly for category 2.

The syndromic category includes mutations that are associated with a substantial degree of increased risk and consistently linked to additional characteristics not required for an ASD diagnosis. If there is independent evidence implicating a gene in idiopathic ASD, it will be listed as "#S" (e.g., 2S, 3S, etc.). If there is no such independent evidence, the gene will be listed simply as "S."

4/1/2021
1
icon
1

Score remained at 1

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

1/1/2021
1
icon
1

Score remained at 1

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

10/1/2020
1
icon
1

Score remained at 1

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

4/1/2020
1
icon
1

Score remained at 1

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

1/1/2020
1
icon
1

Score remained at 1

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

10/1/2019
1S
icon
1

Score remained at 1

New Scoring Scheme
Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

7/1/2019
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

4/1/2019
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

1/1/2019
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

10/1/2018
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

7/1/2018
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR 0.01, meaning that this gene had a 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

10/1/2017
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ? 0.01, meaning that this gene had a ? 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

7/1/2017
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 reported 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ? 0.01, meaning that this gene had a ? 99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

4/1/2017
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 showed 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

Reports Added
[Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.2012] [Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.2012] [Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.2012] [Disruptive CHD8 mutations define a subtype of autism early in development.2014] [Recurrent 100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.2014] [Synaptic, transcriptional and chromatin genes disrupted in autism.2014] [The contribution of de novo coding mutations to autism spectrum disorder2014] [Large-scale discovery of novel genetic causes of developmental disorders.2014] [De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability.2014] [CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.2010] [CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.2014] [The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment.2015] [The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes.2015] [Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.2015] [Low load for disruptive mutations in autism genes and their biased transmission.2015] [A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review.2016] [Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay.2016] [CHD8 intragenic deletion associated with autism spectrum disorder.2016] [Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling.2016] [De novo genic mutations among a Chinese autism spectrum disorder cohort.2016] [The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.2016] [Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.2017] [Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder2017] [Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism.2017]
1/1/2017
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 showed 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

10/1/2016
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 showed 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

1/1/2016
1S
icon
1S

Score remained at 1S

Description

PMID 22495309 showed 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD. This gene was identified in Iossifov et al. 2015 as a strong candidate to be an ASD risk gene based on a combination of de novo mutational evidence and the absence or very low frequency of mutations in controls (PMID 26401017).

Reports Added
[Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.2012] [Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.2012] [Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.2012] [Disruptive CHD8 mutations define a subtype of autism early in development.2014] [Recurrent 100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.2014] [Synaptic, transcriptional and chromatin genes disrupted in autism.2014] [The contribution of de novo coding mutations to autism spectrum disorder2014] [Large-scale discovery of novel genetic causes of developmental disorders.2014] [De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability.2014] [CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.2010] [CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.2014] [The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment.2015] [The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes.2015] [Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.2015] [Low load for disruptive mutations in autism genes and their biased transmission.2015] [A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review.2016] [Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay.2016] [CHD8 intragenic deletion associated with autism spectrum disorder.2016]
4/1/2015
1
icon
1S

Score remained at 1S

Description

PMID 22495309 showed 2 de novo loss-of-function (LoF) mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LoF mutations. A ninth de novo LoF variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LoF variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760). A phenotypic comparison of patients with CHD8 variants in PMID 24998929 identified recurrent dysmorphic facial features suggestive of a syndromic form of ASD.

1/1/2015
1
icon
1

Score remained at 1

Description

PMID 22495309 showed 2 de novo LGD mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LGD mutations. A ninth de novo LGD variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LGD variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760).

10/1/2014
1
icon
1

Score remained at 1

Description

PMID 22495309 showed 2 de novo LGD mutations in CHD8 among 209 simplex ASD families. In a screen of 44 genes in 2,446 ASD probands from the Simons Simplex Collection, PMID 23160955 found 6 additional de novo CHD8 LGD mutations. A ninth de novo LGD variant in CHD8 in an ASD proband from the Simons Simplex Collection was observed in PMID 25363768. Additional LGD variants in CHD8 were identified in children with developmental delay and ASD in PMID 24998929. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders. Analysis of rare coding variation in 3,871 ASD cases and 9,937 ancestry-matched or paternal controls from the Autism Sequencing Consortium (ASC) identified CHD8 as a gene meeting high statistical significance with a FDR ?0.01, meaning that this gene had a ?99% chance of being a true autism gene (PMID 25363760).

7/1/2014
No data
icon
1

Increased from No data to 1

Description

PMID 22495309 showed 2 de novo LGD mutations in CHD8 among 209 ASD families. PMID 22495311 reported 3 additional CHD8 LGD mutations in 935 cases and none among 870 controls. In a screen of 44 genes in 2,446 ASD probands, PMID 23160955 found 9 additional de novo CHD8 LGD mutations. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders.

4/1/2014
No data
icon
1

Increased from No data to 1

Description

PMID 22495309 showed 2 de novo LGD mutations in CHD8 among 209 ASD families. PMID 22495311 reported 3 additional CHD8 LGD mutations in 935 cases and none among 870 controls. In a screen of 44 genes in 2,446 ASD probands, PMID 23160955 found 9 additional de novo CHD8 LGD mutations. PMID 22521361 showed that CHD8 is among 33 loci with balanced chromosomal abnormalities in individuals with ASD or other neurodevelopmental disorders.

Krishnan Probability Score

Score 0.48605406881788

Ranking 7247/25841 scored genes


[Show Scoring Methodology]
Krishnan and colleagues generated probability scores genome-wide by using a machine learning approach on a human brain-specific gene network. The method was first presented in Nat Neurosci 19, 1454-1462 (2016), and scores for more than 25,000 RefSeq genes can be accessed in column G of supplementary table 3 (see: http://www.nature.com/neuro/journal/v19/n11/extref/nn.4353-S5.xlsx). A searchable browser, with the ability to view networks of associated ASD risk genes, can be found at asd.princeton.edu.
ExAC Score

Score 0.99999999999809

Ranking 45/18225 scored genes


[Show Scoring Methodology]
The Exome Aggregation Consortium (ExAC) is a summary database of 60,706 exomes that has been widely used to estimate 'constraint' on mutation for individual genes. It was introduced by Lek et al. Nature 536, 285-291 (2016), and the ExAC browser can be found at exac.broadinstitute.org. The pLI score was developed as measure of intolerance to loss-of- function mutation. A pLI > 0.9 is generally viewed as highly constrained, and thus any loss-of- function mutations in autism in such a gene would be more likely to confer risk. For a full list of pLI scores see: ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3.1/functional_gene_constraint/fordist_cle aned_exac_nonTCGA_z_pli_rec_null_data.txt
Iossifov Probability Score

Score 0.998

Ranking 7/239 scored genes


[Show Scoring Methodology]
Supplementary dataset S2 in the paper by Iossifov et al. (PNAS 112, E5600-E5607 (2015)) lists 239 genes with a probability of at least 0.8 of being associated with autism risk (column I). This probability metric combines the evidence from de novo likely-gene- disrupting and missense mutations and assesses it against the background mutation rate in unaffected individuals from the University of Washington’s Exome Variant Sequence database (evs.gs.washington.edu/EVS/). The list of probability scores can be found here: www.pnas.org/lookup/suppl/doi:10.1073/pnas.1516376112/- /DCSupplemental/pnas.1516376112.sd02.xlsx
Sanders TADA Score

Score 3.056711550542E-10

Ranking 1/18665 scored genes


[Show Scoring Methodology]
The TADA score ('Transmission and De novo Association') was introduced by He et al. PLoS Genet 9(8):e1003671 (2013), and is a statistic that integrates evidence from both de novo and transmitted mutations. It forms the basis for the claim of 65 individual genes being strongly associated with autism risk at a false discovery rate of 0.1 (Sanders et al. Neuron 87, 1215-1233 (2015)). The calculated TADA score for 18,665 RefSeq genes can be found in column P of Supplementary Table 6 in the Sanders et al. paper (the column headed 'tadaFdrAscSscExomeSscAgpSmallDel'), which represents a combined analysis of exome data and small de novo deletions (see www.cell.com/cms/attachment/2038545319/2052606711/mmc7.xlsx).
Larsen Cumulative Evidence Score

Score 262

Ranking 2/461 scored genes


[Show Scoring Methodology]
Larsen and colleagues generated gene scores based on the sum of evidence for all available ASD-associated variants in a gene, with assessments based on mode of inheritance, effect size, and variant frequency in the general population. The approach was first presented in Mol Autism 7:44 (2016), and scores for 461 genes can be found in column I in supplementary table 4 from that paper.
Zhang D Score

Score 0.43689316255242

Ranking 1064/20870 scored genes


[Show Scoring Methodology]
The DAMAGES score (disease-associated mutation analysis using gene expression signatures), or D score, was developed to combine evidence from de novo loss-of- function mutation with evidence from cell-type- specific gene expression in the mouse brain (specifically translational profiles of 24 specific mouse CNS cell types isolated from 6 different brain regions). Genes with positive D scores are more likely to be associated with autism risk, with higher-confidence genes having higher D scores. This statistic was first presented by Zhang & Shen (Hum Mutat 38, 204- 215 (2017), and D scores for more than 20,000 RefSeq genes can be found in column M in supplementary table 2 from that paper.
Interaction Table
Interactor Symbol Interactor Name Interactor Organism Interactor Type Entrez ID Uniprot ID
41703 membrane-associated ring finger (C3HC4) 5 Human DNA Binding NM_017824 Q9NX47
41704 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase Human DNA Binding NM_005885 O60337
41707 membrane-associated ring finger (C3HC4) 9 Human DNA Binding NM_138396 Q86YJ5
41884 septin 2 Human DNA Binding NM_004404 Q15019
41886 septin 4 Human DNA Binding NM_004574 O43236
41889 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase Human DNA Binding NM_022826 B7ZAR7
41893 15 kDa selenoprotein Human DNA Binding NM_004261 O60613
AAK1 AP2 associated kinase 1 Human DNA Binding 22848 Q2M2I8
AAMDC Mth938 domain-containing protein Human DNA Binding 28971 Q9H7C9
AASDH aminoadipate-semialdehyde dehydrogenase Human DNA Binding 132949 Q4L235
ABCA17P ATP-binding cassette, sub-family A (ABC1), member 17, pseudogene Human DNA Binding 650655 NA
ABCA3 Human DNA Binding
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Human DNA Binding 10057 O15440
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 Human DNA Binding 5825 P28288
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 Human DNA Binding 6059 P61221
ABHD10 abhydrolase domain containing 10 Human DNA Binding 55347 Q9NUJ1
ABHD14A abhydrolase domain containing 14A Human DNA Binding NM_015407 Q9BUJ0
ABHD3 abhydrolase domain containing 3 Human DNA Binding NM_138340 Q8WU67
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase Human DNA Binding 25 P00519
ABT1 activator of basal transcription 1 Human DNA Binding 29777 Q9ULW3
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 Human DNA Binding 25841 Q8N961
ACACA acetyl-CoA carboxylase alpha Human DNA Binding 31 Q13085
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain Human DNA Binding 34 P11310
ACADSB Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Human DNA Binding 36 P45954
ACAT1 acetyl-CoA acetyltransferase 1 Human DNA Binding 38 P24752
ACBD5 acyl-CoA binding domain containing 5 Human DNA Binding 91452 Q5T8D3
ACBD6 acyl-CoA binding domain containing 6 Human DNA Binding 84320 B2RAA8
ACIN1 apoptotic chromatin condensation inducer 1 Human DNA Binding 22985 Q9UKV3
ACO1 aconitase 1, soluble Human DNA Binding 48 P21399
ACO2 aconitase 2, mitochondrial Human DNA Binding 50 Q99798
ACOX3 acyl-CoA oxidase 3, pristanoyl Human DNA Binding NM_003501 O15254
ACP1 acid phosphatase 1, soluble Human DNA Binding 52 B5MCC7
ACP2 acid phosphatase 2, lysosomal Human DNA Binding 53 P11117
ACPL2 2-phosphoxylose phosphatase 1 Human DNA Binding 92370 Q8TE99
ACSL3 acyl-CoA synthetase long-chain family member 3 Human DNA Binding 2181 B3KMA6
ACTL6A actin-like 6A Human DNA Binding 86 O96019
ACTR2 ARP2 actin-related protein 2 homolog (yeast) Human DNA Binding 10097 E9PF41
ACTR6 ARP6 actin-related protein 6 homolog (yeast) Human DNA Binding NM_022496 Q9GZN1
ACVR1B activin A receptor, type IB Human DNA Binding 91 P36896
ACVR2A activin A receptor, type IIA Human DNA Binding 92 P27037
ACYP1 acylphosphatase 1, erythrocyte (common) type Human DNA Binding NM_001107 P07311
ACYP2 Acylphosphatase-2 Human DNA Binding 98 P14621
ADAL adenosine deaminase-like Human DNA Binding 161823 Q6DHV7
ADAM17 ADAM metallopeptidase domain 17 Human DNA Binding 6868 B2RNB2
ADAM8 ADAM metallopeptidase domain 8 Human DNA Binding NM_001109 P78325
ADAM9 ADAM metallopeptidase domain 9 Human DNA Binding 8754 Q13443
ADAMTS10 A disintegrin and metalloproteinase with thrombospondin motifs 10 Human DNA Binding 81794 Q9H324
ADAR adenosine deaminase, RNA-specific Human DNA Binding 103 P55265
ADAT2 adenosine deaminase, tRNA-specific 2 Human DNA Binding 134637 Q7Z6V5
ADCK4 aarF domain containing kinase 4 Human DNA Binding 79934 Q96D53
ADCY5 Adenylate cyclase type 5 Human DNA Binding 111 O95622
ADD1 adducin 1 (alpha) Human DNA Binding 118 P35611
ADK adenosine kinase Human DNA Binding 132 P55263
ADM adrenomedullin Human DNA Binding NM_001124 P35318
ADO 2-aminoethanethiol (cysteamine) dioxygenase Human DNA Binding 84890 B3KXN9
ADRM1 adhesion regulating molecule 1 Human DNA Binding 11047 Q16186
ADSL adenylosuccinate lyase Human DNA Binding 158 P30566
ADSS adenylosuccinate synthase Human DNA Binding 159 P30520
AEBP2 AE binding protein 2 Human DNA Binding 121536 Q6ZN18
AFTPH aftiphilin Human DNA Binding 54812 Q6ULP2
AGA aspartylglucosaminidase Human DNA Binding NM_000027 P20933
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Human DNA Binding NM_001042535 Q86ST5
AGK acylglycerol kinase Human DNA Binding 55750 A4D1U5
AGO2 argonaute RISC catalytic component 2 Human DNA Binding 27161 A4FVC0
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 Human DNA Binding 10554 Q99943
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 Human DNA Binding 56894 Q9NRZ7
AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6 Human DNA Binding 137964 Q2TU73
AHCYL2 adenosylhomocysteinase-like 2 Human DNA Binding 23382 Q96HN2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) Human DNA Binding 10598 O95433
AK3 adenylate kinase 3 Human DNA Binding 50808 Q7Z4Y4
AKAP4 A kinase (PRKA) anchor protein 4 Human DNA Binding 8852 Q5JQC9
AKAP8 A kinase (PRKA) anchor protein 8 Human DNA Binding 10270 O43823
AKAP8L A kinase (PRKA) anchor protein 8-like Human DNA Binding 26993 Q9ULX6
AKIRIN1 akirin 1 Human DNA Binding 79647 Q9H9L7
AKIRIN2 akirin 2 Human DNA Binding 55122 Q53H80
AKT1S1 AKT1 substrate 1 (proline-rich) Human DNA Binding 84335 Q96B36
AKT2 v-akt murine thymoma viral oncogene homolog 2 Human DNA Binding 208 B4DG79
ALG10B ALG10B, alpha-1,2-glucosyltransferase Human DNA Binding 144245 Q5I7T1
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit Human DNA Binding NM_144988 Q96F25
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase Human DNA Binding 29880 Q9Y673
ALG9 ALG9, alpha-1,2-mannosyltransferase Human DNA Binding 79796 Q9H6U8
ALKBH5 alkB, alkylation repair homolog 5 (E. coli) Human DNA Binding 54890 Q6P6C2
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) Human DNA Binding 91801 Q96BT7
ALMS1 Alstrom syndrome 1 Human DNA Binding 7840 Q8TCU4
ALOXE3 Hydroperoxide isomerase ALOXE3 Human DNA Binding 59344 Q9BYJ1
ALS2 amyotrophic lateral sclerosis 2 (juvenile) Human DNA Binding NM_001135745 Q96Q42
AMBRA1 autophagy/beclin-1 regulator 1 Human DNA Binding 55626 Q9C0C7
AMHR2 anti-Mullerian hormone receptor, type II Human DNA Binding 269 Q16671
AMMECR1L AMMECR1-like Human DNA Binding 83607 Q6DCA0
AMOTL2 CDH10 Human DNA Binding 51421 Q9Y2J4
ANAPC10 anaphase promoting complex subunit 10 Human DNA Binding 10393 Q9UM13
ANAPC13 anaphase promoting complex subunit 13 Human DNA Binding 25847 A8K3Z6
ANAPC5 anaphase promoting complex subunit 5 Human DNA Binding 51433 Q9UJX4
ANAPC7 anaphase promoting complex subunit 7 Human DNA Binding 51434 Q9UJX3
ANGEL2 angel homolog 2 (Drosophila) Human DNA Binding 90806 Q5VTE6
ANKH ankylosis, progressive homolog (mouse) Human DNA Binding 56172 Q9HCJ1
ANKLE2 Ankyrin repeat and LEM domain-containing protein 2 Human DNA Binding 23141 Q86XL3
ANKRD13A ankyrin repeat domain 13A Human DNA Binding 88455 Q3ZTS7
ANKRD13C ankyrin repeat domain 13C Human DNA Binding 81573 Q8N6S4
ANKRD16 ankyrin repeat domain 16 Human DNA Binding 54522 Q6P6B7
ANKRD32 ankyrin repeat domain 32 Human DNA Binding 84250 I6L9F1
ANKRD34A ankyrin repeat domain 34A Human DNA Binding NM_001039888 Q69YU3
ANKRD40 ankyrin repeat domain 40 Human DNA Binding 91369 A8IK34
ANKRD42 ankyrin repeat domain 42 Human DNA Binding NM_182603 Q8N9B4
ANKRD50 ankyrin repeat domain 50 Human DNA Binding 57182 Q8TB46
ANKRD52 Human DNA Binding
ANLN anillin, actin binding protein Human DNA Binding 54443 Q9NQW6
ANO8 anoctamin 8 Human DNA Binding 57719 Q9HCE9
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Human DNA Binding 10541 Q92688
ANXA2 annexin A2 Human DNA Binding 302 P07355
AP1G1 adaptor-related protein complex 1, gamma 1 subunit Human DNA Binding 164 O43747
AP1M1 adaptor-related protein complex 1, mu 1 subunit Human DNA Binding 8907 Q59EK3
AP1S3 adaptor-related protein complex 1, sigma 3 subunit Human DNA Binding 130340 Q96PC3
AP2A2 adaptor-related protein complex 2, alpha 2 subunit Human DNA Binding 161 O94973
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit Human DNA Binding 23431 B4DM48
AP4M1 adaptor-related protein complex 4, mu 1 subunit Human DNA Binding 9179 O00189
AP4S1 adaptor-related protein complex 4, sigma 1 subunit Human DNA Binding 11154 Q9Y587
AP5B1 AP-5 complex subunit beta-1 Human DNA Binding 91056 Q2VPB7
AP5M1 AP-5 complex subunit mu-1 Human DNA Binding 55745 Q9H0R1
AP5S1 AP-5 complex subunit sigma-1 Human DNA Binding 55317 Q9NUS5
APEH N-acylaminoacyl-peptide hydrolase Human DNA Binding 327 P13798
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 Human DNA Binding 328 P27695
API5 apoptosis inhibitor 5 Human DNA Binding 8539 Q9BZZ5
APIP APAF1 interacting protein Human DNA Binding 51074 Q96GX9
APITD1 Centromere protein S Human DNA Binding 1325 Q8N2Z9
APITD1-CORT Centromere protein S Human DNA Binding 100526739 Q8N2Z9
APLP1 amyloid beta (A4) precursor-like protein 1 Human DNA Binding 333 P51693
APLP2 amyloid beta (A4) precursor-like protein 2 Human DNA Binding 334 Q06481
APOLD1 apolipoprotein L domain containing 1 Human DNA Binding 81575 Q96LR9
APOO apolipoprotein O Human DNA Binding NM_024122 Q9BUR5
APOPT1 Apoptogenic protein 1, mitochondrial Human DNA Binding 84334 Q96IL0
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 Human DNA Binding 10513 Q92624
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Human DNA Binding 26060 Q9UKG1
APTX aprataxin Human DNA Binding 54840 Q7Z2E3
AR androgen receptor Human Protein Binding 367 P10275
ARF4 ADP-ribosylation factor 4 Human DNA Binding 378 P18085
ARF6 ADP-ribosylation factor 6 Human DNA Binding 382 P62330
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 Human DNA Binding 55738 Q8N6T3
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 Human DNA Binding 84364 B4DX29
ARFGEF1 Human DNA Binding
ARFRP1 ADP-ribosylation factor related protein 1 Human DNA Binding NM_003224 Q13795
ARHGAP11B Rho GTPase activating protein 11B Human DNA Binding NM_001039841 Q3KRB8
ARHGAP21 Rho GTPase activating protein 21 Human DNA Binding 57584 Q5T5U3
ARHGAP33 Rho GTPase-activating protein 33 Human DNA Binding 115703 O14559
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha Human DNA Binding 396 P52565
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 Human DNA Binding 9826 O15085
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Human DNA Binding 23365 B4E2K6
ARHGEF7 Human DNA Binding
ARID1B AT rich interactive domain 1B (SWI1-like) Human DNA Binding 57492 Q8NFD5
ARID3A AT rich interactive domain 3A (BRIGHT-like) Human DNA Binding 1820 Q99856
ARID4A AT rich interactive domain 4A (RBP1-like) Human DNA Binding 5926 P29374
ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) Human DNA Binding 25820 Q9Y4X5
ARL13B ADP-ribosylation factor-like 13B Human DNA Binding 200894 Q3SXY8
ARL17P1 ADP-ribosylation factor-like 17A Human DNA Binding NM_001113738 A8K0M5
ARL2BP ADP-ribosylation factor-like 2 binding protein Human DNA Binding 23568 Q9Y2Y0
ARL3 ADP-ribosylation factor-like 3 Human DNA Binding NM_004311 P36405
ARL4A ADP-ribosylation factor-like 4A Human DNA Binding NM_001037164 A0A024R9Z2
ARL5A ADP-ribosylation factor-like 5A Human DNA Binding 26225 Q9Y689
ARL5B ADP-ribosylation factor-like 5B Human DNA Binding 221079 B0YIW9
ARL6 ADP-ribosylation factor-like 6 Human DNA Binding NM_177976 Q9H0F7
ARL6IP6 ADP-ribosylation-like factor 6 interacting protein 6 Human DNA Binding 151188 B3KMZ5
ARL8A ADP-ribosylation factor-like 8A Human DNA Binding 127829 Q96BM9
ARMC1 armadillo repeat containing 1 Human DNA Binding 55156 Q9NVT9
ARMC5 armadillo repeat containing 5 Human DNA Binding 79798 Q96C12
ARMC6 armadillo repeat containing 6 Human DNA Binding 93436 Q6NXE6
ARMCX5 armadillo repeat containing, X-linked 5 Human DNA Binding NM_022838 Q6P1M9
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa Human DNA Binding 10093 F6TTL5
ARPC4-TTLL3 Protein ARPC4-TTLL3 Human DNA Binding 100526693 A0A0A6YYG9
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa Human DNA Binding 10092 O15511
ARPP19 cAMP-regulated phosphoprotein, 19kDa Human DNA Binding 10776 P56211
ARRDC3-AS1 ARRDC3 antisense RNA 1 Human DNA Binding 100129716 NA
ARSB arylsulfatase B Human DNA Binding 411 P15848
ARSK arylsulfatase family, member K Human DNA Binding NM_198150 Q6UWY0
ARV1 ARV1 homolog (S. cerevisiae) Human DNA Binding 64801 Q9H2C2
ASB6 ankyrin repeat and SOCS box containing 6 Human DNA Binding 140459 Q9NWX5
ASB7 ankyrin repeat and SOCS box containing 7 Human DNA Binding 140460 Q9H672
ASCC3 activating signal cointegrator 1 complex subunit 3 Human DNA Binding 10973 Q8N3C0
ASF1A Histone chaperone ASF1A Human DNA Binding 25842 Q9Y294
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) Human DNA Binding 55723 Q9NVP2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) Human DNA Binding 55870 Q9NR48
ASH1L-AS1 ASH1L antisense RNA 1 Human DNA Binding 645676 NA
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) Human Protein Binding 9070 Q9UBL3
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) Human DNA Binding NM_004317 O43681
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 Human DNA Binding 79058 Q9BZE9
ASXL1 additional sex combs like 1 (Drosophila) Human DNA Binding 171023 Q498B9
ATAD2B ATPase family, AAA domain containing 2B Human DNA Binding 54454 Q9ULI0
ATAD3A ATPase family, AAA domain containing 3A Human DNA Binding 55210 Q9NVI7
ATAD5 ATPase family, AAA domain containing 5 Human DNA Binding 79915 Q96QE3
ATE1 arginyltransferase 1 Human DNA Binding 11101 O95260
ATF6 activating transcription factor 6 Human DNA Binding 22926 A8K383
ATF7 activating transcription factor 7 Human DNA Binding NM_006856 P17544
ATF7IP activating transcription factor 7 interacting protein Human DNA Binding 55729 Q6VMQ6
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) Human DNA Binding 55054 Q53SV2
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) Human DNA Binding NM_033388 Q8NAA4
ATG3 Ubiquitin-like-conjugating enzyme ATG3 Human DNA Binding 64422 Q9NT62
ATL1 Atlastin-1 Human DNA Binding 51062 Q8WXF7
ATL3 atlastin GTPase 3 Human DNA Binding 25923 Q6DD88
ATN1 atrophin 1 Human DNA Binding 1822 P54259
ATP10D CYFIP1 Human DNA Binding 57205 Q9P241
ATP11A ATPase, class VI, type 11A Human DNA Binding 23250 P98196
ATP11B ATPase, class VI, type 11B Human DNA Binding 23200 B4DKX1
ATP1B1 Human DNA Binding
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Human DNA Binding 487 O14983
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit Human DNA Binding NM_006886 P56381
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 Human DNA Binding 515 P24539
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) Human DNA Binding 516 P05496
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) Human DNA Binding 517 Q06055
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E Human DNA Binding 521 P56385
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c Human DNA Binding 527 P27449
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 Human DNA Binding NM_004691 P61421
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A Human DNA Binding 523 P38606
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 Human DNA Binding 9550 O75348
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 Human DNA Binding 534 Q2L6F8
ATP6V1G2-DDX39B ATP6V1G2-DDX39B readthrough (NMD candidate) Human DNA Binding 100532737 NA
ATRAID All-trans retinoic acid-induced differentiation factor Human DNA Binding 51374 Q6UW56
ATRN attractin Human DNA Binding 8455 B4DZ36
ATXN10 ataxin 10 Human DNA Binding 25814 Q9UBB4
ATXN2 ataxin 2 Human DNA Binding 6311 Q99700
ATXN2L ataxin 2-like Human DNA Binding 11273 Q8WWM7
ATXN3 ataxin 3 Human DNA Binding 4287 E9PB63
ATXN7 ataxin 7 Human DNA Binding 6314 O15265
ATXN7L2 ataxin 7-like 2 Human DNA Binding 127002 Q5T6C5
AUP1 ancient ubiquitous protein 1 Human DNA Binding 550 Q9Y679
AVEN Cell death regulator Aven Human DNA Binding 57099 Q9NQS1
AVL9 AVL9 homolog (S. cerevisiase) Human DNA Binding 23080 Q8NBF6
B2M beta-2-microglobulin Human DNA Binding 567 P61769
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 Human DNA Binding 148789 Q8NCR0
B4GALNT1 Beta-1,4 N-acetylgalactosaminyltransferase 1 Human DNA Binding 2583 Q00973
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 Human DNA Binding 9334 O43286
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 Human DNA Binding 9331 Q9UBX8
B4GALT7 DNM1L Human DNA Binding 11285 Q9UBV7
B9D1 B9 protein domain 1 Human DNA Binding NM_015681 B4DN64
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 Human DNA Binding 60468 Q9BYV9
BAD Bcl2-associated agonist of cell death Human DNA Binding 572 Q92934
BAG2 BCL2-associated athanogene 2 Human DNA Binding 9532 O95816
BAG5 BCL2-associated athanogene 5 Human DNA Binding 9529 Q9UL15
BAHCC1 DPP6 Human DNA Binding 57597 Q9P281
BANF1 barrier to autointegration factor 1 Human DNA Binding 8815 O75531
BANP BTG3 associated nuclear protein Human DNA Binding 54971 B3KM38
BAT1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B Human DNA Binding NM_080598 A0A024RCM3
BAT2 proline-rich coiled-coil 2A Human DNA Binding 7916 P48634
BAT2L proline-rich coiled-coil 2B Human DNA Binding NM_013318 Q5JSZ5
BAT3 BCL2-associated athanogene 6 Human DNA Binding 7917 P46379
BAT4 G patch domain and ankyrin repeats 1 Human DNA Binding NM_033177 A0A024RCU2
BAT5 DUSP22 Human DNA Binding 7920 B3KNX9
BAZ1B bromodomain adjacent to zinc finger domain, 1B Human DNA Binding 9031 Q9UIG0
BBS10 Bardet-Biedl syndrome 10 Human DNA Binding 79738 Q8TAM1
BBS4 Bardet-Biedl syndrome 4 Human DNA Binding 585 Q96RK4
BBS5 Bardet-Biedl syndrome 5 Human DNA Binding 129880 Q8N3I7
BBX bobby sox homolog (Drosophila) Human DNA Binding 56987 A8K6U2
BCAR1 breast cancer anti-estrogen resistance 1 Human DNA Binding 9564 B4DEV4
BCAS2 breast carcinoma amplified sequence 2 Human DNA Binding 10286 B2R7W3
BCAS4 breast carcinoma amplified sequence 4 Human DNA Binding NM_017843 H7BXG3
BCAT1 branched chain amino-acid transaminase 1, cytosolic Human DNA Binding 586 P54687
BCL2 B-cell CLL/lymphoma 2 Human DNA Binding 596 P10415
BCL2L1 BCL2-like 1 Human DNA Binding 598 Q07817
BCL2L12 BCL2-like 12 (proline rich) Human DNA Binding 83596 Q9HB09
BCL2L13 BCL2-like 13 (apoptosis facilitator) Human DNA Binding 23786 Q9BXK5
BCL9 B-cell CLL/lymphoma 9 Human DNA Binding 607 O00512
BCR breakpoint cluster region Human DNA Binding 613 P11274
BEND3 BEN domain containing 3 Human DNA Binding 57673 Q5T5X7
BFAR bifunctional apoptosis regulator Human DNA Binding 51283 Q9NZS9
BHLHE41 basic helix-loop-helix family, member e41 Human DNA Binding 79365 Q8TAT1
BICD2 bicaudal D homolog 2 (Drosophila) Human DNA Binding 23299 Q8TD16
BIRC6 baculoviral IAP repeat containing 6 Human DNA Binding 57448 Q9NR09
BLMH bleomycin hydrolase Human DNA Binding 642 Q13867
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Human DNA Binding 26258 B3KY40
BLZF1 basic leucine zipper nuclear factor 1 Human DNA Binding 8548 Q9H2G9
BMPR1A bone morphogenetic protein receptor, type IA Human DNA Binding 657 P36894
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) Human DNA Binding 659 Q13873
BMS1 BMS1 homolog, ribosome assembly protein (yeast) Human DNA Binding 9790 Q14692
BMS1P4 BMS1 pseudogene 4 Human DNA Binding NR_026592
BMS1P5 BMS1 pseudogene 5 Human DNA Binding NR_003611
BNC2 basonuclin 2 Human DNA Binding 54796 Q6ZN30
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 Human DNA Binding NM_013980 Q12981
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 Human DNA Binding 663 J3KN59
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like Human DNA Binding 665 O60238
BOD1 biorientation of chromosomes in cell division 1 Human DNA Binding 91272 Q96IK1
BOD1L biorientation of chromosomes in cell division 1-like 1 Human DNA Binding 259282 Q8NFC6
BOLA3 bolA homolog 3 (E. coli) Human DNA Binding 388962 Q53S33
BOLA3-AS1 BOLA3 antisense RNA 1 (head to head) Human DNA Binding 100507171 NA
BPGM 2,3-bisphosphoglycerate mutase Human DNA Binding 669 P07738
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 Human DNA Binding NM_006085 O95861
BPTF bromodomain PHD finger transcription factor Human DNA Binding 2186 Q12830
BRAF Serine/threonine-protein kinase B-raf Human DNA Binding 673 P15056
BRD8 bromodomain containing 8 Human DNA Binding 10902 Q9H0E9
BRD9 Bromodomain-containing protein 9 Human DNA Binding 65980 Q9H8M2
BRF2 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like Human DNA Binding 55290 Q9HAW0
BRIX1 BRX1, biogenesis of ribosomes, homolog (S. cerevisiae) Human DNA Binding 55299 Q8TDN6
BRWD1-AS1 BRWD1 antisense RNA 1 Human DNA Binding 100874093 NA
BRWD1-IT2 Human DNA Binding 103091865 NA
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) Human DNA Binding NM_001130702 A0A024R540
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) Human DNA Binding 9044 O14981
BTBD1 BTB (POZ) domain containing 1 Human DNA Binding 53339 Q9H0C5
BTBD2 BTB (POZ) domain containing 2 Human DNA Binding 55643 Q9BX70
BTF3 basic transcription factor 3 Human DNA Binding 689 P20290
BTF3L4 basic transcription factor 3-like 4 Human DNA Binding 91408 Q96K17
BTG3 BTG family, member 3 Human DNA Binding 10950 Q14201
BUD13 BUD13 homolog (S. cerevisiae) Human DNA Binding 84811 Q9BRD0
BZW1 basic leucine zipper and W2 domains 1 Human DNA Binding 9689 Q3LIC9
C10orf104 anaphase promoting complex subunit 16 Human DNA Binding NM_173473 C5H3H2
C10orf114 cancer susceptibility candidate 10 Human DNA Binding NM_001010911 Q5T4H9
C10orf119 minichromosome maintenance complex binding protein Human DNA Binding NM_024834 Q9BTE3
C10orf137 chromosome 10 open reading frame 137 Human DNA Binding 26098 Q3B7T1
C10orf140 chromosome 10 open reading frame 140 Human DNA Binding 387640 Q1XH10
C10orf2 chromosome 10 open reading frame 2 Human DNA Binding 56652 Q96RR1
C10ORF25 Uncharacterized protein C10orf25 Human DNA Binding 220979 Q5T742
C10orf28 R3H domain and coiled-coil containing 1-like Human DNA Binding 27291 D3DR60
C10orf4 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 Human DNA Binding NM_145246 Q70Z53
C10orf57 transmembrane protein 254 Human DNA Binding NM_025125 B4DU43
C10orf78 SWI5-dependent recombination repair 1 Human DNA Binding NM_145247 Q86XK3
C11orf10 transmembrane protein 258 Human DNA Binding NM_014206 P61165
C11orf46 ADP-ribosylation factor-like 14 effector protein Human DNA Binding 120534 Q8N8R7
C11orf48 chromosome 11 open reading frame 48 Human DNA Binding 79081 Q9BQE6
C11orf58 chromosome 11 open reading frame 58 Human DNA Binding 10944 O00193
C11orf59 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Human DNA Binding NM_017907 Q6IAA8
C11ORF68 UPF0696 protein C11orf68 Human DNA Binding 83638 Q9H3H3
C11orf82 chromosome 11 open reading frame 82 Human DNA Binding 220042 Q8IXT1
C11ORF84 chromosome 11 open reading frame 84 Human DNA Binding 144097 Q9BUA3
C11ORF95 Uncharacterized protein C11orf95 Human DNA Binding 65998 C9JLR9
C12orf10 chromosome 12 open reading frame 10 Human DNA Binding 60314 Q86UA3
C12ORF23 chromosome 12 open reading frame 23 Human DNA Binding 90488 Q8WUH6
C12orf30 N(alpha)-acetyltransferase 25, NatB auxiliary subunit Human DNA Binding NM_024953 Q14CX7
C12ORF52 chromosome 12 open reading frame 52 Human DNA Binding 84934 Q96K30
C12orf57 chromosome 12 open reading frame 57 Human DNA Binding 113246 Q99622
C12ORF60 Uncharacterized protein C12orf60 Human DNA Binding 144608 Q5U649
C12ORF61 Putative uncharacterized protein encoded by LINC01465 Human DNA Binding 283416 Q8N7H1
C12orf65 chromosome 12 open reading frame 65 Human DNA Binding 91574 Q9H3J6
C12orf72 methyltransferase like 20 Human DNA Binding NM_173802 Q8IXQ9
C13orf23 proline and serine rich 1 Human DNA Binding NM_025138 Q86XN7
C14orf101 transmembrane protein 260 Human DNA Binding NM_017799 B3KN73
C14orf106 MIS18 binding protein 1 Human DNA Binding NM_018353 Q6P0N0
C14orf119 chromosome 14 open reading frame 119 Human DNA Binding NM_017924 Q9NWQ9
C14orf135 chromosome 14 open reading frame 135 Human DNA Binding 64430 Q63HM2
C14orf178 chromosome 14 open reading frame 178 Human DNA Binding NM_174943 F8WAD5
C14orf181 Human DNA Binding NM_207442
C14orf33 KTN1 antisense RNA 1 Human DNA Binding NR_027123 Q86SY8
C14ORF80 chromosome 14 open reading frame 80 Human DNA Binding 283643 E9PAQ4
C14orf93 chromosome 14 open reading frame 93 Human DNA Binding NM_001130706 Q9H972
C15orf23 kinetochore-localized astrin/SPAG5 binding protein Human DNA Binding 90417 Q9Y448
C15orf33 family with sequence similarity 227, member B Human DNA Binding NM_152647 Q96M60
C16orf45 chromosome 16 open reading frame 45 Human DNA Binding NM_033201 Q96MC5
C16orf58 chromosome 16 open reading frame 58 Human DNA Binding 64755 Q96GQ5
C16orf61 C-x(9)-C motif containing 2 Human DNA Binding NM_020188 Q9NRP2
C16orf62 chromosome 16 open reading frame 62 Human DNA Binding 57020 E7EWW0
C16orf7 VPS9 domain containing 1 Human DNA Binding NM_004913 Q9Y2B5
C16orf72 chromosome 16 open reading frame 72 Human DNA Binding 29035 Q14CZ0
C16orf80 chromosome 16 open reading frame 80 Human DNA Binding 29105 Q9Y6A4
C16ORF87 chromosome 16 open reading frame 87 Human DNA Binding 388272 Q6PH81
C16orf88 chromosome 16 open reading frame 88 Human DNA Binding 400506 Q1ED39
C17orf59 chromosome 17 open reading frame 59 Human DNA Binding NM_017622 Q96GS4
C17orf70 chromosome 17 open reading frame 70 Human DNA Binding 80233 A4ZI32
C17ORF75 chromosome 17 open reading frame 75 Human DNA Binding 64149 Q9HAS0
C18orf25 chromosome 18 open reading frame 25 Human DNA Binding 147339 Q96B23
C18orf54 chromosome 18 open reading frame 54 Human DNA Binding 162681 I7GY12
C18orf55 translocase of inner mitochondrial membrane 21 homolog (yeast) Human DNA Binding 29090 A8K1K8
C19orf12 chromosome 19 open reading frame 12 Human DNA Binding 83636 Q9NSK7
C19orf2 URI1, prefoldin-like chaperone Human DNA Binding 8725 O94763
C19orf39 SWIM-type zinc finger 7 associated protein 1 Human DNA Binding NM_175871 Q6NVH7
C19ORF43 chromosome 19 open reading frame 43 Human DNA Binding 79002 Q9BQ61
C19orf48 chromosome 19 open reading frame 48 Human DNA Binding 84798 Q6RUI8
C19orf54 chromosome 19 open reading frame 54 Human DNA Binding 284325 Q5BKX5
C19orf55 chromosome 19 open reading frame 55 Human DNA Binding 148137 Q2NL68
C19ORF60 Uncharacterized protein C19orf60 Human DNA Binding 55049 Q96EN9
C19orf61 SMG9 nonsense mediated mRNA decay factor Human DNA Binding NM_019108 A0A024R0Q0
C19orf62 BRISC and BRCA1 A complex member 1 Human DNA Binding NM_014173 A0A024R7L2
C19orf76 adrenomedullin 5 (putative) Human DNA Binding NM_001101340 C9JUS6
C1D C1D nuclear receptor corepressor Human DNA Binding 10438 Q13901
C1orf107 digestive organ expansion factor homolog (zebrafish) Human DNA Binding NM_014388 Q68CQ4
C1orf109 chromosome 1 open reading frame 109 Human DNA Binding 54955 Q9NX04
C1orf112 chromosome 1 open reading frame 112 Human DNA Binding 55732 Q9NSG2
C1ORF122 chromosome 1 open reading frame 122 Human DNA Binding 127687 E9PQ13
C1orf151 mitochondrial inner membrane organizing system 1 Human DNA Binding NM_001032363 Q5TGZ0
C1orf156 methyltransferase like 18 Human DNA Binding NM_033418 A0A024R8Y7
C1ORF174 chromosome 1 open reading frame 174 Human DNA Binding 339448 Q8IYL3
C1orf182 TSSK6 activating co-chaperone Human DNA Binding NM_144627 Q96A04
C1ORF198 chromosome 1 open reading frame 198 Human DNA Binding 84886 B3KTW1
C1ORF21 chromosome 1 open reading frame 21 Human DNA Binding 81563 Q9H246
C1orf213 chromosome 1 open reading frame 213 Human DNA Binding 148898 Q8NC38
C1orf231 coiled-coil domain containing 163, pseudogene Human DNA Binding NM_001102601
C1orf27 chromosome 1 open reading frame 27 Human DNA Binding 54953 Q5SWX8
C1ORF35 chromosome 1 open reading frame 35 Human DNA Binding 79169 Q9BU76
C1orf43 chromosome 1 open reading frame 43 Human DNA Binding 25912 Q9BWL3
C1orf52 chromosome 1 open reading frame 52 Human DNA Binding 148423 Q8N6N3
C1orf55 SDE2 telomere maintenance homolog (S. pombe) Human DNA Binding NM_152608 Q6IQ49
C1orf71 consortin, connexin sorting protein Human DNA Binding NM_001139459 Q6PJW8
C1orf83 transcription elongation factor A (SII) N-terminal and central domain containing 2 Human DNA Binding NM_153035 Q96MN5
C1orf9 SUN domain containing ossification factor Human DNA Binding 51430 Q9UBS9
C1orf96 centriole, cilia and spindle-associated protein Human DNA Binding 126731 Q6IQ19
C1orf97 long intergenic non-protein coding RNA 467 Human DNA Binding NR_026761 Q9BRT7
C20ORF112 chromosome 20 open reading frame 112 Human DNA Binding 140688 Q6P0R2
C20ORF196 chromosome 20 open reading frame 196 Human DNA Binding 149840 Q8IYI0
C20orf199 ZNFX1 antisense RNA 1 Human DNA Binding NR_003604
C20orf24 chromosome 20 open reading frame 24 Human DNA Binding 55969 Q9BUV8
C20orf29 adaptor-related protein complex 5, sigma 1 subunit Human DNA Binding 55317 Q9NUS5
C20orf3 adipocyte plasma membrane associated protein Human DNA Binding 57136 Q9HDC9
C20orf30 transmembrane protein 230 Human DNA Binding NM_014145 Q96A57
C20orf4 AAR2 splicing factor homolog (S. cerevisiae) Human DNA Binding 25980 Q9Y312
C20orf72 mitochondrial genome maintenance exonuclease 1 Human DNA Binding 92667 Q9BQP7
C20orf94 SLX4 interacting protein Human DNA Binding 128710 Q5VYV7
C21orf2 chromosome 21 open reading frame 2 Human DNA Binding NM_004928 O43822
C21orf34 mir-99a-let-7c cluster host gene (non-protein coding) Human DNA Binding NR_027790 A1L4M7
C21orf45 MIS18 kinetochore protein A Human DNA Binding NM_018944 Q9NYP9
C21ORF49 Putative uncharacterized protein C21orf62-AS1 Human DNA Binding 54067 Q17RA5
C21orf57 ybeY metallopeptidase (putative) Human DNA Binding NM_001006114 Q8TBC8
C21orf91 chromosome 21 open reading frame 91 Human DNA Binding 54149 Q68DA1
C22ORF24 Uncharacterized protein C22orf24 Human DNA Binding 25775 Q9Y442
C22orf28 chromosome 22 open reading frame 28 Human DNA Binding 51493 Q9Y3I0
C22ORF29 chromosome 22 open reading frame 29 Human DNA Binding 79680 Q7L3V2
C22orf32 single-pass membrane protein with aspartate-rich tail 1 Human DNA Binding NM_033318 Q9H4I9
C2orf28 all-trans retinoic acid-induced differentiation factor Human DNA Binding 51374 Q6UW56
C2orf29 CCR4-NOT transcription complex, subunit 11 Human DNA Binding 55571 Q9UKZ1
C2orf3 GC-rich sequence DNA-binding factor 2 Human DNA Binding 6936 A4UHR0
C2orf34 calmodulin-lysine N-methyltransferase Human DNA Binding NM_024766 Q7Z624
C2orf42 chromosome 2 open reading frame 42 Human DNA Binding NM_017880 Q9NWW7
C2orf43 chromosome 2 open reading frame 43 Human DNA Binding 60526 Q9H6V9
C2ORF47 chromosome 2 open reading frame 47 Human DNA Binding 79568 Q8WWC4
C2orf52 long intergenic non-protein coding RNA 471 Human DNA Binding NR_024079
C2orf64 cytochrome c oxidase assembly factor 5 Human DNA Binding NM_001008215 Q86WW8
C2orf69 chromosome 2 open reading frame 69 Human DNA Binding 205327 Q8N8R5
C2orf79 peptidyl-tRNA hydrolase domain containing 1 Human DNA Binding NM_001013663 Q6GMV3
C2orf86 WD repeat containing planar cell polarity effector Human DNA Binding NM_015910 O95876
C3orf1 translocase of inner mitochondrial membrane domain containing 1 Human DNA Binding NM_016589 Q9NPL8
C3orf19 coiled-coil domain containing 174 Human DNA Binding 51244 Q6PII3
C4orf21 chromosome 4 open reading frame 21 Human DNA Binding 55345 B4DSN6
C4orf34 small integral membrane protein 14 Human DNA Binding 201895 Q96QK8
C4orf41 trafficking protein particle complex 11 Human DNA Binding 60684 Q7Z392
C4orf43 translation machinery associated 16 homolog (S. cerevisiae) Human DNA Binding 55319 Q96EY4
C4orf46 chromosome 4 open reading frame 46 Human DNA Binding NM_001008393 Q504U0
C4ORF48 Neuropeptide-like protein C4orf48 Human DNA Binding 401115 Q5BLP8
C5orf15 chromosome 5 open reading frame 15 Human DNA Binding 56951 Q8NC54
C5orf24 chromosome 5 open reading frame 24 Human DNA Binding 134553 Q7Z6I8
C5ORF28 chromosome 5 open reading frame 28 Human DNA Binding 64417 Q0VDI3
C5orf34 chromosome 5 open reading frame 34 Human DNA Binding 375444 Q96MH7
C5orf35 SET domain containing 9 Human DNA Binding NM_153706 Q8NE22
C5orf36 KIAA0825 Human DNA Binding NM_173665 Q8IV33
C5orf37 POC5 centriolar protein Human DNA Binding NM_001099271 Q8NA72
C5orf39 annexin A2 receptor Human DNA Binding NM_001014279 Q3ZCQ2
C5orf41 CREB3 regulatory factor Human DNA Binding 153222 Q8IUR6
C5orf44 trafficking protein particle complex 13 Human DNA Binding NR_003545 A5PLN9
C5orf51 chromosome 5 open reading frame 51 Human DNA Binding 285636 A6NDU8
C6orf115 ABRA C-terminal like Human DNA Binding NM_021243 Q9P1F3
C6orf120 chromosome 6 open reading frame 120 Human DNA Binding 387263 Q7Z4R8
C6orf129 coiled-coil domain containing 167 Human DNA Binding NM_138493 Q9P0B6
C6ORF136 Uncharacterized protein C6orf136 Human DNA Binding 221545 Q5SQH8
C6orf142 muscular LMNA-interacting protein Human DNA Binding NM_138569 Q5VWP3
C6orf145 PX domain containing 1 Human DNA Binding 221749 Q5TGL8
C6orf162 small integral membrane protein 8 Human DNA Binding 57150 Q96KF7
C6ORF211 chromosome 6 open reading frame 211 Human DNA Binding 79624 Q9H993
C6orf217 long intergenic non-protein coding RNA 271 Human DNA Binding NR_026805 P0C7V0
C6orf57 chromosome 6 open reading frame 57 Human DNA Binding NM_145267 Q5VUM1
C6orf62 chromosome 6 open reading frame 62 Human DNA Binding 81688 Q9GZU0
C7ORF10 chromosome 7 open reading frame 10 Human DNA Binding 79783 Q9HAC7
C7ORF25 chromosome 7 open reading frame 25 Human DNA Binding 79020 J3KR36
C7ORF26 chromosome 7 open reading frame 26 Human DNA Binding 79034 Q96N11
C7orf30 mitochondrial assembly of ribosomal large subunit 1 Human DNA Binding 115416 Q96EH3
C7orf36 Yae1 domain containing 1 Human DNA Binding 57002 B2RC46
C7orf38 family with sequence similarity 200, member A Human DNA Binding NM_145111 Q8TCP9
C7orf55 chromosome 7 open reading frame 55 Human DNA Binding NM_197964 Q96HJ9
C7ORF55-LUC7L2 UPF0562 protein C7orf55 Human DNA Binding 100996928 Q96HJ9
C7orf60 chromosome 7 open reading frame 60 Human DNA Binding 154743 Q1RMZ1
C8G Complement component C8 gamma chain Human DNA Binding 733 P07360
C8orf37 chromosome 8 open reading frame 37 Human DNA Binding NM_177965 F4Y588
C8orf39 RBM12B antisense RNA 1 Human DNA Binding NR_027259 Q9P1G2
C8orf40 small integral membrane protein 19 Human DNA Binding 114926 Q96E16
C8orf41 TELO2 interacting protein 2 Human DNA Binding 80185 Q6NXR4
C8orf59 chromosome 8 open reading frame 59 Human DNA Binding NM_001099670 A0A024R838
C9orf130 long intergenic non-protein coding RNA 476 Human DNA Binding NR_023389 Q8WZB0
C9orf156 chromosome 9 open reading frame 156 Human DNA Binding 51531 Q9BU70
C9ORF169 Cysteine-rich tail protein 1 Human DNA Binding 375791 A8MQ03
C9orf30 chromosome 9 open reading frame 30 Human DNA Binding 91283 Q96H12
C9orf40 chromosome 9 open reading frame 40 Human DNA Binding 55071 Q8IXQ3
C9orf41 chromosome 9 open reading frame 41 Human DNA Binding 138199 Q8N4J0
C9ORF43 Uncharacterized protein C9orf43 Human DNA Binding 257169 Q8TAL5
C9orf5 transmembrane protein 245 Human DNA Binding 23731 Q9H330
C9ORF69 Protein C9orf69 Human DNA Binding 90120 H0YL14
C9orf78 chromosome 9 open reading frame 78 Human DNA Binding 51759 Q9NZ63
C9orf82 caspase activity and apoptosis inhibitor 1 Human DNA Binding 79886 Q9H8G2
C9ORF96 Serine/threonine kinase-like domain-containing protein STKLD1 Human DNA Binding 169436 Q8NE28
CA11 carbonic anhydrase XI Human DNA Binding NM_001217 O75493
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Human Direct Regulation 8913 O43497
CACTIN Cactin Human DNA Binding 58509 Q8WUQ7
CACYBP calcyclin binding protein Human DNA Binding 27101 B3KSF1
CAMK2N1 Human DNA Binding
CAMSAP1 calmodulin regulated spectrin-associated protein 1 Human DNA Binding 157922 Q5T5Y3
CAMSAP1L1 calmodulin regulated spectrin-associated protein family, member 2 Human DNA Binding 23271 B3KTI4
CAND1 cullin-associated and neddylation-dissociated 1 Human DNA Binding 55832 Q86VP6
CAPRIN1 cell cycle associated protein 1 Human DNA Binding 4076 Q14444
CAPRIN2 caprin family member 2 Human DNA Binding 65981 Q6IMN6
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 Human DNA Binding 829 P52907
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 Human DNA Binding 830 P47755
CAPZB capping protein (actin filament) muscle Z-line, beta Human DNA Binding 832 P47756
CARD8 caspase recruitment domain family, member 8 Human DNA Binding 22900 B5KVR6
CARM1 coactivator-associated arginine methyltransferase 1 Human DNA Binding 10498 Q86X55
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) Human DNA Binding 79587 B7Z7E6
CASC5 cancer susceptibility candidate 5 Human DNA Binding 57082 Q8NG31
CASKIN2 CASK interacting protein 2 Human DNA Binding 57513 Q8WXE0
CASP2 caspase 2, apoptosis-related cysteine peptidase Human DNA Binding 835 D3DXD9
CASP3 caspase 3, apoptosis-related cysteine peptidase Human DNA Binding 836 P42574
CASP8AP2 caspase 8 associated protein 2 Human DNA Binding NM_012115 Q9UKL3
CBLL1 Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1 Human DNA Binding 79872 B4DDV7
CBWD2 COBW domain containing 2 Human DNA Binding 150472 Q8IUF1
CBX3P2 chromobox homolog 3 pseudogene 2 Human DNA Binding 645158 NA
CBX4 chromobox homolog 4 Human DNA Binding 8535 O00257
CBX8 chromobox homolog 8 Human DNA Binding 57332 Q9HC52
CCAR1 cell division cycle and apoptosis regulator 1 Human DNA Binding 55749 Q8IX12
CCBL1 cysteine conjugate-beta lyase, cytoplasmic Human DNA Binding 883 A8K563
CCDC102B coiled-coil domain containing 102B Human DNA Binding NM_001093729 A1A4H1
CCDC109A mitochondrial calcium uniporter Human DNA Binding NM_138357 Q8NE86
CCDC111 DNA-directed primase/polymerase protein Human DNA Binding 201973 Q96LW4
CCDC115 Coiled-coil domain-containing protein 115 Human DNA Binding 84317 Q96NT0
CCDC136 coiled-coil domain containing 136 Human DNA Binding 64753 Q96JN2
CCDC137 coiled-coil domain containing 137 Human DNA Binding 339230 Q6PK04
CCDC142 coiled-coil domain containing 142 Human DNA Binding 84865 Q17RM4
CCDC18 coiled-coil domain containing 18 Human DNA Binding 343099 E9PFB9
CCDC45 centrosomal protein 95kDa Human DNA Binding NM_138363 Q96GE4
CCDC47 coiled-coil domain containing 47 Human DNA Binding 57003 Q96A33
CCDC49 CWC25 spliceosome-associated protein homolog (S. cerevisiae) Human DNA Binding NM_017748 Q9NXE8
CCDC50 coiled-coil domain containing 50 Human DNA Binding 152137 Q8IVM0
CCDC55 nuclear speckle splicing regulatory protein 1 Human DNA Binding NM_032141 A0A024QZ33
CCDC56 coiled-coil domain containing 56 Human DNA Binding 28958 Q9Y2R0
CCDC57 coiled-coil domain containing 57 Human DNA Binding 284001 Q2TAC2
CCDC58 coiled-coil domain containing 58 Human DNA Binding NM_001017928 Q4VC31
CCDC66 coiled-coil domain containing 66 Human DNA Binding 285331 A2RUB6
CCDC71L Coiled-coil domain-containing protein 71L Human DNA Binding 168455 Q8N9Z2
CCDC76 tRNA methyltransferase 13 homolog (S. cerevisiae) Human DNA Binding NM_019083 Q9NUP7
CCDC77 Coiled-coil domain-containing protein 77 Human DNA Binding 84318 Q9BR77
CCDC83 coiled-coil domain containing 83 Human DNA Binding NM_173556 Q8IWF9
CCDC84 coiled-coil domain containing 84 Human DNA Binding NM_198489 Q86UT8
CCDC85C coiled-coil domain containing 85C Human DNA Binding 317762 A6NKD9
CCDC88A coiled-coil domain containing 88A Human DNA Binding 55704 Q3V6T2
CCDC90B coiled-coil domain containing 90B Human DNA Binding 60492 Q9GZT6
CCDC92 Coiled-coil domain-containing protein 92 Human DNA Binding 80212 Q53HC0
CCDC97 coiled-coil domain containing 97 Human DNA Binding 90324 Q96F63
CCM2 cerebral cavernous malformation 2 Human DNA Binding 83605 Q9BSQ5
CCNE2 cyclin E2 Human DNA Binding 9134 O96020
CCNG2 cyclin G2 Human DNA Binding 901 Q16589
CCNI cyclin I Human DNA Binding 10983 Q14094
CCNL1 cyclin L1 Human DNA Binding 57018 Q9UK58
CCPG1 HUWE1 Human DNA Binding 9236 Q9ULG6
CCSAP Centriole, cilia and spindle-associated protein Human DNA Binding 126731 Q6IQ19
CD164 CD164 molecule, sialomucin Human DNA Binding 8763 Q04900
CD276 CD276 molecule Human DNA Binding 80381 Q5ZPR3
CD3EAP CD3e molecule, epsilon associated protein Human DNA Binding 10849 O15446
CD47 CD47 molecule Human DNA Binding 961 Q08722
CDC123 cell division cycle 123 homolog (S. cerevisiae) Human DNA Binding 8872 O75794
CDC14A cell division cycle 14A Human DNA Binding NM_033313 Q59EF4
CDC20 cell division cycle 20 Human DNA Binding 991 Q12834
CDC2L5 cyclin-dependent kinase 13 Human DNA Binding NM_003718 A0A024RA85
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) Human DNA Binding 9578 Q86XZ8
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 Human DNA Binding 10602 Q9UKI2
CDC42SE1 CDC42 small effector 1 Human DNA Binding 56882 Q9NRR8
CDC45L cell division cycle 45 Human DNA Binding NM_003504 O75419
CDC6 cell division cycle 6 homolog (S. cerevisiae) Human DNA Binding 990 Q99741
CDC7 cell division cycle 7 Human DNA Binding 8317 O00311
CDC73 cell division cycle 73 Human DNA Binding 79577 Q6P1J9
CDK13 cyclin-dependent kinase 13 Human DNA Binding 8621 Q14004
CDK19 cyclin-dependent kinase 19 Human DNA Binding 23097 Q9BWU1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 Human DNA Binding 8099 F5GYA4
CDK5RAP2 CDK5 regulatory subunit associated protein 2 Human DNA Binding 55755 B3KVI2
CDK7 cyclin-dependent kinase 7 Human DNA Binding 1022 P50613
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 Human DNA Binding 54901 Q5VV42
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Human Direct Regulation 1029 P42771
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Human DNA Binding 1030 P42772
CDKN2BAS CDKN2B antisense RNA 1 Human DNA Binding NR_003529
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 Human DNA Binding 8760 O95674
CDV3 CDV3 homolog (mouse) Human DNA Binding 55573 Q9UKY7
CEBPD CCAAT/enhancer binding protein (C/EBP), delta Human DNA Binding NM_005195 P49716
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon Human DNA Binding NM_001805 Q15744
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma Human DNA Binding 1054 P53567
CECR2 cat eye syndrome chromosome region, candidate 2 Human DNA Binding 27443 Q9BXF3
CECR6 Cat eye syndrome critical region protein 6 Human DNA Binding 27439 Q9BXQ6
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) Human DNA Binding 1951 Q9NYQ7
CENPA centromere protein A Human DNA Binding 1058 P49450
CENPF centromere protein F, 350/400kDa (mitosin) Human DNA Binding 1063 P49454
CENPH centromere protein H Human DNA Binding 64946 Q9H3R5
CENPL centromere protein L Human DNA Binding 91687 Q8N0S6
CENPQ centromere protein Q Human DNA Binding 55166 Q7L2Z9
CEP104 centrosomal protein 104kDa Human DNA Binding 9731 O60308
CEP164 centrosomal protein 164kDa Human DNA Binding 22897 Q9UPV0
CEP170 centrosomal protein 170kDa Human DNA Binding 9859 Q5SW79
CEP250 centrosomal protein 250kDa Human DNA Binding 11190 Q9BV73
CEP350 centrosomal protein 350kDa Human DNA Binding 9857 Q5VT06
CEP68 centrosomal protein 68kDa Human DNA Binding 23177 Q76N32
CEP95 Centrosomal protein of 95 kDa Human DNA Binding 90799 Q96GE4
CEP97 centrosomal protein 97kDa Human DNA Binding 79598 Q8IW35
CERS2 ceramide synthase 2 Human DNA Binding 29956 Q96G23
CFL1 cofilin 1 (non-muscle) Human DNA Binding 1072 P23528
CFLAR CASP8 and FADD-like apoptosis regulator Human DNA Binding 8837 O15519
CGRRF1 cell growth regulator with ring finger domain 1 Human DNA Binding NM_006568 Q99675
CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 Human DNA Binding 283489 Q96JM3
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 Human DNA Binding 118487 Q96BP2
CHCHD2 KIT Human DNA Binding 51142 Q9Y6H1
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 Human DNA Binding 54927 A4D1N4
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 Human DNA Binding 79145 Q9BUK0
CHD1 chromodomain helicase DNA binding protein 1 Human DNA Binding 1105 B3KT33
CHD9 chromodomain helicase DNA binding protein 9 Human DNA Binding 80205 Q3L8U1
CHERP calcium homeostasis endoplasmic reticulum protein Human DNA Binding 10523 Q8IWX8
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase Human DNA Binding 55743 Q96EP1
CHIC2 cysteine-rich hydrophobic domain 2 Human DNA Binding 26511 Q9UKJ5
CHM choroideremia (Rab escort protein 1) Human DNA Binding 1121 P24386
CHMP6 charged multivesicular body protein 6 Human DNA Binding 79643 Q96FZ7
CHP calcineurin-like EF-hand protein 1 Human DNA Binding 11261 Q99653
CHRAC1 chromatin accessibility complex 1 Human DNA Binding 54108 Q9NRG0
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) Human DNA Binding 1138 P30532
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) Human DNA Binding NM_000749 Q05901
CHUK conserved helix-loop-helix ubiquitous kinase Human DNA Binding 1147 O15111
CIC capicua transcriptional repressor Human DNA Binding 23152 Q96RK0
CIRBP-AS1 CIRBP antisense RNA 1 Human DNA Binding 148046 Q8TBR5
CISD1 CDGSH iron sulfur domain 1 Human DNA Binding 55847 Q9NZ45
CISD2 CDGSH iron sulfur domain 2 Human DNA Binding NM_001008388 Q8N5K1
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 Human DNA Binding NM_001144886 Q99966
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 Human DNA Binding 10370 D9ZGF1
CIZ1 CDKN1A interacting zinc finger protein 1 Human DNA Binding 25792 Q9BTG3
CKAP2L cytoskeleton associated protein 2-like Human DNA Binding 150468 Q8IYA6
CKAP5 cytoskeleton associated protein 5 Human DNA Binding 9793 Q14008
CKLF chemokine-like factor Human DNA Binding 51192 Q9UBR5
CKLF-CMTM1 Protein CKLF-CMTM1 Human DNA Binding 100529251 A0A087WVB3
CKS2 CDC28 protein kinase regulatory subunit 2 Human DNA Binding 1164 P33552
CLASP1 cytoplasmic linker associated protein 1 Human DNA Binding 23332 A2RU21
CLCC1 chloride channel CLIC-like 1 Human DNA Binding 23155 Q96S66
CLCN3 chloride channel, voltage-sensitive 3 Human DNA Binding 1182 B7Z932
CLIC1 chloride intracellular channel 1 Human DNA Binding 1192 O00299
CLIC4 chloride intracellular channel 4 Human DNA Binding 25932 Q6FIC5
CLIP4 CAP-Gly domain-containing linker protein 4 Human DNA Binding 79745 Q8N3C7
CLK1 CDC-like kinase 1 Human DNA Binding 1195 P49759
CLK2 CDC-like kinase 2 Human DNA Binding 1196 P49760
CLK3 CDC-like kinase 3 Human DNA Binding 1198 B3KRI8
CLK4 CDC-like kinase 4 Human DNA Binding 57396 Q9HAZ1
CLOCK clock circadian regulator Human DNA Binding 9575 O15516
CLPTM1 cleft lip and palate associated transmembrane protein 1 Human DNA Binding 1209 B3KQH2
CLPX ClpX caseinolytic peptidase X homolog (E. coli) Human DNA Binding 10845 O76031
CLTA clathrin, light chain A Human DNA Binding 1211 P09496
CLUAP1 Clusterin-associated protein 1 Human DNA Binding 23059 Q96AJ1
CLUH Clustered mitochondria protein homolog Human DNA Binding 23277 O75153
CMIP c-Maf inducing protein Human DNA Binding 80790 Q8IY22
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic Human DNA Binding 51727 E9PGI8
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 Human DNA Binding NM_178868 Q8IZV2
CNBP CCHC-type zinc finger, nucleic acid binding protein Human DNA Binding 7555 A8K7V4
CNEP1R1 Nuclear envelope phosphatase-regulatory subunit 1 Human DNA Binding 255919 Q8N9A8
CNIH cornichon homolog (Drosophila) Human DNA Binding 10175 O95406
CNN3 calponin 3, acidic Human DNA Binding 1266 Q15417
CNNM2 cyclin M2 Human DNA Binding 54805 Q9H8M5
CNO biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino Human DNA Binding 55330 Q9NUP1
CNOT1 CCR4-NOT transcription complex, subunit 1 Human DNA Binding 23019 A5YKK6
CNOT11 CCR4-NOT transcription complex subunit 11 Human DNA Binding 55571 Q9UKZ1
CNOT2 CCR4-NOT transcription complex, subunit 2 Human DNA Binding 4848 B2RDX7
CNOT3 CCR4-NOT transcription complex, subunit 3 Human DNA Binding 4849 O75175
CNOT4 CCR4-NOT transcription complex, subunit 4 Human DNA Binding 4850 O95628
CNOT6 CCR4-NOT transcription complex, subunit 6 Human DNA Binding 57472 Q9ULM6
CNOT6L CCR4-NOT transcription complex, subunit 6-like Human DNA Binding 246175 Q96LI5
CNOT8 CCR4-NOT transcription complex, subunit 8 Human DNA Binding 9337 Q9UFF9
CNPPD1 cyclin Pas1/PHO80 domain containing 1 Human DNA Binding 27013 Q9BV87
CNPY3 canopy FGF signaling regulator 3 Human DNA Binding NM_006586 Q9BT09
CNPY4 canopy FGF signaling regulator 4 Human DNA Binding NM_152755 Q8N129
COA5 Cytochrome c oxidase assembly factor 5 Human DNA Binding 493753 Q86WW8
COG2 component of oligomeric golgi complex 2 Human DNA Binding 22796 Q14746
COIL coilin Human DNA Binding 8161 P38432
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein Human DNA Binding 10087 Q9Y5P4
COL4A6 collagen, type IV, alpha 6 Human DNA Binding 1288 Q14031
COL5A2 MKL2 Human DNA Binding 1290 P05997
COMMD2 COMM domain containing 2 Human DNA Binding 51122 Q86X83
COMMD3 COMM domain containing 3 Human DNA Binding NM_012071 Q9UBI1
COPA coatomer protein complex, subunit alpha Human DNA Binding 1314 P53621
COPB1 coatomer protein complex, subunit beta 1 Human DNA Binding 1315 P53618
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) Human DNA Binding 51138 B3KST5
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) Human DNA Binding 10987 Q92905
COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) Human DNA Binding 50813 Q9UBW8
COPS7B COP9 signalosome subunit 7B Human DNA Binding 64708 Q9H9Q2
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) Human DNA Binding 10920 Q53QS9
COPZ1 coatomer protein complex, subunit zeta 1 Human DNA Binding 22818 P61923
COQ2 coenzyme Q2 homolog, prenyltransferase (yeast) Human DNA Binding 27235 Q96H96
COQ3 coenzyme Q3 methyltransferase Human DNA Binding NM_017421 Q9NZJ6
COQ4 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Human DNA Binding 51117 Q9Y3A0
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) Human DNA Binding 84274 Q5HYK3
CORO2B Coronin-2B Human DNA Binding 10391 Q9UQ03
COX11 cytochrome c oxidase assembly homolog 11 (yeast) Human DNA Binding 1353 B4DEY8
COX15 cytochrome c oxidase assembly homolog 15 (yeast) Human DNA Binding 1355 Q7KZN9
COX18 cytochrome c oxidase assembly homolog 18 (yeast) Human DNA Binding 285521 Q8N8Q8
COX20 Cytochrome c oxidase protein 20 homolog Human DNA Binding 116228 Q5RI15
COX4I1 cytochrome c oxidase subunit IV isoform 1 Human DNA Binding 1327 P13073
COX5A cytochrome c oxidase subunit Va Human DNA Binding 9377 P20674
COX5B cytochrome c oxidase subunit Vb Human DNA Binding 1329 P10606
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 Human DNA Binding 1337 H6SG15
COX6C cytochrome c oxidase subunit VIc Human DNA Binding NM_004374 A0A024R9B7
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) Human DNA Binding NM_001865 H0UI06
COX7C cytochrome c oxidase subunit VIIc Human DNA Binding 1350 P15954
CP110 centriolar coiled coil protein 110kDa Human DNA Binding 9738 B4DTZ1
CPEB3 cytoplasmic polyadenylation element binding protein 3 Human DNA Binding 22849 Q5QP71
CPEB4 cytoplasmic polyadenylation element binding protein 4 Human DNA Binding 80315 Q17RY0
CPNE1 copine I Human DNA Binding 8904 B0QZ18
CPPED1 calcineurin-like phosphoesterase domain containing 1 Human DNA Binding 55313 Q9BRF8
CPS1 carbamoyl-phosphate synthase 1, mitochondrial Human DNA Binding 1373 J3KQL0
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa Human DNA Binding 53981 Q9P2I0
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa Human DNA Binding 51692 Q9UKF6
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa Human DNA Binding 11052 Q16630
CPT1A carnitine palmitoyltransferase 1A (liver) Human DNA Binding 1374 P50416
CPT1C carnitine palmitoyltransferase 1C Human DNA Binding NM_152359 A0A024QZI3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain Human DNA Binding 8738 P78560
CRBN Protein cereblon Human DNA Binding 51185 Q96SW2
CREB3 cAMP responsive element binding protein 3 Human DNA Binding NM_006368 O43889
CREBL2 cAMP responsive element binding protein-like 2 Human DNA Binding 1389 O60519
CREBRF CREB3 regulatory factor Human DNA Binding 153222 Q8IUR6
CRELD1 cysteine-rich with EGF-like domains 1 Human DNA Binding 78987 Q96HD1
CREM cAMP responsive element modulator Human DNA Binding 1390 Q03060
CRIPT cysteine-rich PDZ-binding protein Human DNA Binding NM_014171 Q9P021
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like Human DNA Binding 1399 P46109
CRLS1 cardiolipin synthase 1 Human DNA Binding 54675 Q9UJA2
CROCC ciliary rootlet coiled-coil, rootletin Human DNA Binding 9696 Q5TZA2
CROCCL2 ciliary rootlet coiled-coil, rootletin pseudogene 3 Human DNA Binding NR_023386
CROT Human DNA Binding NR_026585
CRY1 cryptochrome 1 (photolyase-like) Human DNA Binding 1407 A2I2P0
CRYL1 crystallin, lambda 1 Human DNA Binding NM_015974 Q9Y2S2
CRYZ crystallin, zeta (quinone reductase) Human DNA Binding NM_001134759 Q08257
CRYZL1 crystallin, zeta (quinone reductase)-like 1 Human DNA Binding 9946 O95825
CS citrate synthase Human DNA Binding 1431 O75390
CSNK1G1 casein kinase 1, gamma 1 Human DNA Binding 53944 Q9HCP0
CSPP1 centrosome and spindle pole associated protein 1 Human DNA Binding NM_024790 Q1MSJ5
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa Human DNA Binding 1477 Q05048
CTAGE5 CTAGE family, member 5 Human DNA Binding 4253 O15320
CTBP1-AS1 CTBP1 antisense RNA 1 Human DNA Binding 92070 Q0VAR9
CTBP2 C-terminal binding protein 2 Human DNA Binding 1488 P56545
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 Human DNA Binding 10106 O14595
CTTNBP2 cortactin binding protein 2 Human DNA Binding 83992 Q8WZ74
CTTNBP2NL CTTNBP2 N-terminal like Human DNA Binding 55917 Q9P2B4
CTU1 cytosolic thiouridylase subunit 1 homolog (S. pombe) Human DNA Binding 90353 Q7Z7A3
CUGBP1 CUGBP, Elav-like family member 1 Human DNA Binding NM_006560 Q92879
CUL1 cullin 1 Human DNA Binding 8454 Q13616
CUL4A cullin 4A Human DNA Binding 8451 Q13619
CUTA cutA divalent cation tolerance homolog (E. coli) Human DNA Binding 51596 O60888
CUTC cutC copper transporter homolog (E. coli) Human DNA Binding 51076 Q9NTM9
CUX1 cut like homeobox 1 Human DNA Binding 1523 Q13948
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) Human DNA Binding 10283 Q6UX04
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) Human DNA Binding 55280 Q69YN2
CXorf56 chromosome X open reading frame 56 Human DNA Binding NM_022101 Q9H5V9
CYB5A cytochrome b5 type A (microsomal) Human DNA Binding 1528 P00167
CYB5B cytochrome b5 type B (outer mitochondrial membrane) Human DNA Binding 80777 J3KNF8
CYB5D1 cytochrome b5 domain containing 1 Human DNA Binding 124637 Q6P9G0
CYB5D2 cytochrome b5 domain containing 2 Human DNA Binding 124936 Q8WUJ1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 Human DNA Binding NM_016593 B7Z786
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 Human DNA Binding 1595 Q16850
CYR61 NXPH1 Human DNA Binding 3491 O00622
CYTSA sperm antigen with calponin homology and coiled-coil domains 1-like Human DNA Binding NM_001145468 B2RMV2
DACH1 dachshund homolog 1 (Drosophila) Human DNA Binding 1602 D0FY36
DALRD3 DALR anticodon binding domain containing 3 Human DNA Binding 55152 Q5D0E6
DAPK1 death-associated protein kinase 1 Human Direct Regulation 1612 P53355
DARS2 aspartyl-tRNA synthetase 2, mitochondrial Human DNA Binding 55157 Q6PI48
DAZAP2 DAZ associated protein 2 Human DNA Binding 9802 E9PB45
DBF4 DBF4 homolog (S. cerevisiae) Human DNA Binding 10926 Q9UBU7
DBN1 drebrin 1 Human DNA Binding 1627 Q16643
DBT dihydrolipoamide branched chain transacylase E2 Human DNA Binding 1629 P11182
DCAF10 DDB1 and CUL4 associated factor 10 Human DNA Binding 79269 Q5QP82
DCAF11 DDB1 and CUL4 associated factor 11 Human DNA Binding 80344 B3KSW2
DCAF17 DDB1- and CUL4-associated factor 17 Human DNA Binding 80067 Q5H9S7
DCAF5 DDB1 and CUL4 associated factor 5 Human DNA Binding 8816 Q96JK2
DCAF6 DDB1 and CUL4 associated factor 6 Human DNA Binding NM_018442 Q58WW2
DCAF8 DDB1 and CUL4 associated factor 8 Human DNA Binding 50717 B7Z8C9
DCDC2 doublecortin domain containing 2 Human DNA Binding 51473 Q9UHG0
DCLK2 Serine/threonine-protein kinase DCLK2 Human DNA Binding 166614 Q8N568
DCLRE1A DNA cross-link repair 1A Human DNA Binding 9937 Q6PJP8
DCLRE1C DNA cross-link repair 1C Human DNA Binding 64421 Q96SD1
DCP1A mRNA-decapping enzyme 1A Human DNA Binding 55802 Q9NPI6
DCP2 DCP2 decapping enzyme homolog (S. cerevisiae) Human DNA Binding 167227 Q8IU60
DCPS decapping enzyme, scavenger Human DNA Binding 28960 Q96C86
DCTN4 dynactin 4 (p62) Human DNA Binding 51164 Q9UJW0
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 Human DNA Binding 23142 Q92564
DDAH1 dimethylarginine dimethylaminohydrolase 1 Human DNA Binding 23576 B4E3V1
DDB2 damage-specific DNA binding protein 2, 48kDa Human DNA Binding 1643 Q92466
DDHD1 DDHD domain containing 1 Human DNA Binding 80821 Q8NEL9
DDHD2 DDHD domain containing 2 Human DNA Binding 23259 O94830
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) Human DNA Binding 84301 Q5TDH0
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase Human DNA Binding 1650 P39656
DDR1 discoidin domain receptor tyrosine kinase 1 Human DNA Binding 780 Q08345
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 Human DNA Binding 9188 Q9NR30
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 Human DNA Binding 9416 Q9BUQ8
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 Human DNA Binding 55794 Q9NUL7
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 Human DNA Binding 64794 Q9H8H2
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B Human DNA Binding 7919 Q13838
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked Human DNA Binding 1654 O00571
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 Human DNA Binding 51428 Q9UJV9
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 Human DNA Binding 9879 Q7L014
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 Human DNA Binding 54555 Q9Y6V7
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 Human DNA Binding 1655 P17844
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 Human DNA Binding 79009 Q9BQ39
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 Human DNA Binding 79039 Q8TDD1
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 Human DNA Binding 83479 Q5T1V6
DEDD death effector domain containing Human DNA Binding 9191 O75618
DEK DEK oncogene Human DNA Binding 7913 P35659
DEM1 exonuclease 5 Human DNA Binding 64789 Q9H790
DENND1B DENN/MADD domain containing 1B Human DNA Binding 163486 Q6P3S1
DENND4A DENN/MADD domain containing 4A Human DNA Binding 10260 Q05C90
DENND4C DENN/MADD domain containing 4C Human DNA Binding 55667 Q5VZ89
DENND5A DENN/MADD domain containing 5A Human DNA Binding NM_015213 Q6IQ26
DENND5B DENN/MADD domain containing 5B Human DNA Binding 160518 Q6ZUT9
DENND5B-AS1 DENND5B antisense RNA 1 Human DNA Binding 100874249 NA
DENND6B Protein DENND6B Human DNA Binding 414918 Q8NEG7
DEPDC1B DEP domain containing 1B Human DNA Binding 55789 Q8WUY9
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide Human DNA Binding 1676 O00273
DFFB DNA fragmentation factor subunit beta Human DNA Binding 1677 O76075
DGKA diacylglycerol kinase, alpha 80kDa Human DNA Binding NM_001345 A0A024RB23
DHDDS dehydrodolichyl diphosphate synthase Human DNA Binding 79947 Q86SQ9
DHRS12 dehydrogenase/reductase (SDR family) member 12 Human DNA Binding NM_024705 A0PJE2
DHRS13 dehydrogenase/reductase (SDR family) member 13 Human DNA Binding 147015 Q6UX07
DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 Human DNA Binding 1665 O43143
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 Human DNA Binding 54505 Q7Z478
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 Human DNA Binding 22907 Q7L2E3
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 Human DNA Binding 56919 B4DIS6
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 Human DNA Binding 9704 Q14147
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 Human DNA Binding 60625 F5GXM6
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 Human DNA Binding 170506 Q9H2U1
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 Human DNA Binding 79665 B4DR88
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 Human DNA Binding 90957 Q6P158
DIAPH1 diaphanous homolog 1 (Drosophila) Human DNA Binding 1729 E9PEZ2
DIAPH2 diaphanous homolog 2 (Drosophila) Human DNA Binding 1730 O60879
DICER1 dicer 1, ribonuclease type III Human DNA Binding 23405 Q9UPY3
DICER1-AS1 DICER1 antisense RNA 1 Human DNA Binding 400242 NA
DIDO1 death inducer-obliterator 1 Human DNA Binding 11083 Q9BTC0
DIMT1L DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) Human DNA Binding NM_014473 Q9UNQ2
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) Human DNA Binding 22982 Q9Y2E4
DIRC2 disrupted in renal carcinoma 2 Human DNA Binding 84925 Q96SL1
DIS3L DIS3 mitotic control homolog (S. cerevisiae)-like Human DNA Binding 115752 Q8TF46
DIS3L2 DIS3 mitotic control homolog (S. cerevisiae)-like 2 Human DNA Binding 129563 Q8IYB7
DKC1 dyskeratosis congenita 1, dyskerin Human Protein Binding 1736 O60832
DKK1 dickkopf 1 homolog (Xenopus laevis) Human DNA Binding 22943 O94907
DKKL1 dickkopf-like 1 Human DNA Binding NM_014419 Q9UK85
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding) Human DNA Binding NR_002612
DLG1-AS1 DLG1 antisense RNA 1 Human DNA Binding 100507086 NA
DLG5 discs, large homolog 5 (Drosophila) Human DNA Binding 9231 Q8TDM6
DLG5-AS1 DLG5 antisense RNA 1 Human DNA Binding 100128292 NA
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 Human DNA Binding 9787 Q15398
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) Human DNA Binding 1743 B7Z6J1
DLX3 distal-less homeobox 3 Human DNA Binding 1747 O60479
DMBX1 diencephalon/mesencephalon homeobox 1 Human DNA Binding NM_147192 Q8NFW5
DMTF1 cyclin D binding myb-like transcription factor 1 Human DNA Binding 9988 B3KMJ8
DMXL1 Dmx-like 1 Human DNA Binding 1657 Q9Y485
DMXL2 Dmx-like 2 Human DNA Binding NM_015263 Q8TDJ6
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 Human DNA Binding 3301 P31689
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 Human DNA Binding 10294 O60884
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 Human DNA Binding 79982 Q8TBM8
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 Human DNA Binding 11080 Q9UDY4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 Human DNA Binding 10049 O75190
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 Human DNA Binding 54431 Q8IXB1
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 Human DNA Binding 55735 Q9NVH1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 Human DNA Binding 23341 Q9Y2G8
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 Human DNA Binding 27000 Q99543
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 Human DNA Binding 51277 Q9NZQ0
DNAJC27-AS1 DNAJC27 antisense RNA 1 Human DNA Binding 729723 NA
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 Human DNA Binding 7266 Q99615
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 Human DNA Binding 23234 B2RMW6
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha Human DNA Binding 1788 Q9Y6K1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta Human Protein Binding 1789 Q9UBC3
DOCK7 dedicator of cytokinesis 7 Human DNA Binding 85440 Q96N67
DOT1L DOT1-like histone H3K79 methyltransferase Human DNA Binding 84444 Q8TEK3
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) Human DNA Binding 1798 Q9H3H5
DPH5 DPH5 homolog (S. cerevisiae) Human DNA Binding 51611 B3KWP1
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 Human DNA Binding NM_018973 Q9P2X0
DPP3 dipeptidyl-peptidase 3 Human DNA Binding 10072 Q9NY33
DPP8 dipeptidyl-peptidase 8 Human DNA Binding 54878 Q6V1X1
DPP9 dipeptidyl-peptidase 9 Human DNA Binding 91039 Q86TI2
DPY19L3 dpy-19-like 3 (C. elegans) Human DNA Binding 147991 Q6ZPD9
DPY19L4 dpy-19-like 4 (C. elegans) Human DNA Binding 286148 Q7Z388
DPYSL5 dihydropyrimidinase-like 5 Human DNA Binding 56896 Q9BPU6
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) Human DNA Binding 1810 Q01658
DRAM2 DNA-damage regulated autophagy modulator 2 Human DNA Binding 128338 Q6UX65
DRAXIN Draxin Human DNA Binding 374946 Q8NBI3
DSCR3 Down syndrome critical region gene 3 Human DNA Binding 10311 O14972
DSE dermatan sulfate epimerase Human DNA Binding 29940 Q9UL01
DSTYK dual serine/threonine and tyrosine protein kinase Human DNA Binding 25778 Q6XUX3
DTD1 D-tyrosyl-tRNA deacylase 1 Human DNA Binding 92675 Q8TEA8
DTWD1 DTW domain containing 1 Human DNA Binding NM_020234 Q8N5C7
DTYMK deoxythymidylate kinase (thymidylate kinase) Human DNA Binding 1841 B7ZW70
DULLARD CTD nuclear envelope phosphatase 1 Human DNA Binding NM_001143775 O95476
DUS2L tRNA-dihydrouridine(20) synthase [NAD(P)+]-like Human DNA Binding 54920 Q9NX74
DUSP16 dual specificity phosphatase 16 Human DNA Binding 80824 Q9BY84
DUSP4 dual specificity phosphatase 4 Human DNA Binding 1846 Q13115
DUSP5P dual specificity phosphatase 5 pseudogene 1 Human DNA Binding NR_002834
DUSP6 dual specificity phosphatase 6 Human DNA Binding 1848 Q16828
DUSP7 dual specificity phosphatase 7 Human DNA Binding 1849 Q16829
DVL3 dishevelled, dsh homolog 3 (Drosophila) Human DNA Binding 1857 Q92997
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 Human DNA Binding 1778 Q14204
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 Human DNA Binding 1781 Q13409
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 Human DNA Binding 51143 Q9Y6G9
DYNLRB1 dynein, light chain, roadblock-type 1 Human DNA Binding 83658 Q9NP97
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Human DNA Binding 1859 Q13627
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Human DNA Binding 8444 O43781
DZIP1 DAZ interacting protein 1 Human DNA Binding 22873 Q86YF9
E4F1 E4F transcription factor 1 Human DNA Binding 1877 Q66K89
EARS2 glutamyl-tRNA synthetase 2, mitochondrial Human DNA Binding 124454 Q5JPH6
ECH1 enoyl CoA hydratase 1, peroxisomal Human DNA Binding 1891 Q13011
ECHDC1 enoyl CoA hydratase domain containing 1 Human DNA Binding 55862 Q9NTX5
ECT2 epithelial cell transforming sequence 2 oncogene Human DNA Binding 1894 Q9H8V3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 Human DNA Binding 9695 Q92611
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 Human DNA Binding 55741 Q9BV94
EED embryonic ectoderm development Human DNA Binding 8726 O75530
EEF2K eukaryotic elongation factor-2 kinase Human DNA Binding 29904 O00418
EFCAB11 EF-hand calcium binding domain 11 Human DNA Binding 90141 Q9BUY7
EFCAB2 EF-hand calcium binding domain 2 Human DNA Binding NM_032328 Q5VUJ9
EFCAB5 EF-hand calcium binding domain 5 Human DNA Binding NM_001145053 A4FU69
EFCAB7 EF-hand calcium binding domain 7 Human DNA Binding 84455 A8K855
EFHA1 mitochondrial calcium uptake 2 Human DNA Binding NM_152726 Q8IYU8
EFHC1 EF-hand domain (C-terminal) containing 1 Human DNA Binding 114327 B2CKC5
EFNA5 ephrin-A5 Human DNA Binding 1946 P52803
EGLN1 egl nine homolog 1 (C. elegans) Human DNA Binding 54583 Q9GZT9
EGR3 Human DNA Binding
EHBP1 EH domain binding protein 1 Human DNA Binding 23301 Q8NDI1
EHMT2 euchromatic histone-lysine N-methyltransferase 1 Human DNA Binding 79813 Q9H9B1
EIF1 eukaryotic translation initiation factor 1 Human DNA Binding 10209 P41567
EIF1AD eukaryotic translation initiation factor 1A domain containing Human DNA Binding 84285 Q8N9N8
EIF1AX eukaryotic translation initiation factor 1A, X-linked Human DNA Binding 1964 P47813
EIF2A eukaryotic translation initiation factor 2A, 65kDa Human DNA Binding 83939 Q9BY44
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa Human DNA Binding 8890 Q9UI10
EIF2C2 eukaryotic translation initiation factor 2C, 2 Human DNA Binding 27161 Q9UKV8
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa Human DNA Binding 1965 P05198
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa Human DNA Binding 8894 P20042
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa Human DNA Binding 1968 P41091
EIF3A eukaryotic translation initiation factor 3, subunit A Human DNA Binding 8661 Q14152
EIF3B eukaryotic translation initiation factor 3, subunit B Human DNA Binding 8662 P55884
EIF3D eukaryotic translation initiation factor 3, subunit D Human DNA Binding 8664 O15371
EIF3F eukaryotic translation initiation factor 3, subunit F Human DNA Binding 8665 O00303
EIF3L eukaryotic translation initiation factor 3, subunit L Human DNA Binding 51386 B4DYB2
EIF3M eukaryotic translation initiation factor 3, subunit M Human DNA Binding 10480 Q7L2H7
EIF4B eukaryotic translation initiation factor 4B Human DNA Binding 1975 P23588
EIF4E eukaryotic translation initiation factor 4E Human DNA Binding 1977 P06730
EIF4E2 eukaryotic translation initiation factor 4E family member 2 Human DNA Binding 9470 O60573
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 Human DNA Binding 56478 Q9NRA8
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 Human DNA Binding 1982 P78344
EIF4G3 Human DNA Binding
ELAC2 elaC homolog 2 (E. coli) Human DNA Binding 60528 Q9BQ52
ELF2 E74-like factor 2 (ets domain transcription factor) Human DNA Binding 1998 Q15723
ELMO2 Human DNA Binding
ELMOD3 ELMO/CED-12 domain containing 3 Human DNA Binding 84173 Q96FG2
ELMSAN1 ELM2 and SANT domain-containing protein 1 Human DNA Binding 91748 Q6PJG2
ELOVL1 ELOVL fatty acid elongase 1 Human DNA Binding NM_022821 Q9BW60
ELOVL5 ELOVL fatty acid elongase 5 Human DNA Binding 60481 Q9NYP7
ELOVL6 ELOVL fatty acid elongase 6 Human DNA Binding 79071 Q9H5J4
ELP2 elongator acetyltransferase complex subunit 2 Human DNA Binding 55250 Q6IA86
ELP3 elongator acetyltransferase complex subunit 3 Human DNA Binding 55140 Q9H9T3
EMC1 ER membrane protein complex subunit 1 Human DNA Binding 23065 Q8N766
EMC8 ER membrane protein complex subunit 8 Human DNA Binding 10328 O43402
EMG1 EMG1 N1-specific pseudouridine methyltransferase Human DNA Binding NM_006331 Q92979
EML1 echinoderm microtubule associated protein like 1 Human DNA Binding 2009 O00423
EML6 echinoderm microtubule associated protein like 6 Human DNA Binding NM_001039753 Q6ZMW3
EMP3 epithelial membrane protein 3 Human DNA Binding NM_001425 A0A024QZF8
ENAH enabled homolog (Drosophila) Human DNA Binding 55740 Q8N8S7
ENO1 enolase 1, (alpha) Human DNA Binding 2023 E2DRY6
ENOPH1 Enolase-phosphatase E1 Human DNA Binding 58478 Q9UHY7
ENOX2 ecto-NOX disulfide-thiol exchanger 2 Human DNA Binding 10495 Q16206
ENSA endosulfine alpha Human DNA Binding 2029 O43768
EP400 E1A binding protein p400 Human DNA Binding 57634 Q96L91
EPB41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) Human DNA Binding 2035 P11171
EPC1 enhancer of polycomb homolog 1 (Drosophila) Human DNA Binding 80314 Q9H2F5
EPC2 enhancer of polycomb homolog 2 (Drosophila) Human DNA Binding 26122 Q52LR7
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) Human DNA Binding 7957 O95278
EPN1 epsin 1 Human DNA Binding NM_013333 Q9Y6I3
EPR1 Human DNA Binding NR_002219
EPRS glutamyl-prolyl-tRNA synthetase Human DNA Binding 2058 P07814
ERAP1 endoplasmic reticulum aminopeptidase 1 Human DNA Binding NM_001040458 Q9NZ08
ERC1 ELKS/RAB6-interacting/CAST family member 1 Human DNA Binding 23085 Q8IUD2
ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) Human DNA Binding 2071 P19447
ERF Ets2 repressor factor Human DNA Binding 2077 P50548
ERH enhancer of rudimentary homolog (Drosophila) Human DNA Binding 2079 P84090
ERI1 exoribonuclease 1 Human DNA Binding 90459 Q8IV48
ERLEC1 endoplasmic reticulum lectin 1 Human DNA Binding 27248 B5MC72
ERLIN1 ER lipid raft associated 1 Human DNA Binding 10613 D3DR65
ERN1 endoplasmic reticulum to nucleus signaling 1 Human DNA Binding NM_001433 O75460
ESCO1 establishment of cohesion 1 homolog 1 (S. cerevisiae) Human DNA Binding 114799 Q5FWF5
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) Human DNA Binding 51575 Q9H501
ESYT2 extended synaptotagmin-like protein 2 Human DNA Binding 57488 A0FGR8
ETAA1 Ewing tumor-associated antigen 1 Human DNA Binding 54465 Q9NY74
ETF1 eukaryotic translation termination factor 1 Human DNA Binding 2107 P62495
ETV1 ets variant 1 Human DNA Binding NM_001163148 P50549
ETV3 ets variant 3 Human DNA Binding 2117 P41162
ETV5 ets variant 5 Human DNA Binding 2119 P41161
ETV6 ets variant 6 Human DNA Binding 2120 P41212
EWSR1 Ewing sarcoma breakpoint region 1 Human DNA Binding 2130 Q01844
EXD2 exonuclease 3'-5' domain containing 2 Human DNA Binding 55218 Q9NVH0
EXO1 exonuclease 1 Human DNA Binding 9156 Q9UQ84
EXOC4 exocyst complex component 4 Human DNA Binding 60412 E9PED2
EXOC5 exocyst complex component 5 Human DNA Binding 10640 O00471
EXOC6 exocyst complex component 6 Human DNA Binding 54536 B3KXY5
EXOC7 exocyst complex component 7 Human DNA Binding 23265 Q9UPT5
EXOSC6 exosome component 6 Human DNA Binding 118460 Q5RKV6
EXOSC8 exosome component 8 Human DNA Binding 11340 Q96B26
EXT1 exostosin 1 Human DNA Binding 2131 Q16394
EXTL3 exostosin-like glycosyltransferase 3 Human DNA Binding 2137 O43909
FABP5L3 fatty acid binding protein 5 pseudogene 3 Human DNA Binding NR_002935 A8MUU1
FADS1 fatty acid desaturase 1 Human DNA Binding 3992 O60427
FADS2 fatty acid desaturase 2 Human DNA Binding 9415 O95864
FAIM Fas apoptotic inhibitory molecule Human DNA Binding NM_018147 Q9NVQ4
FAM102A family with sequence similarity 102, member A Human DNA Binding 399665 Q5T9C2
FAM108B1 family with sequence similarity 108, member B1 Human DNA Binding 51104 Q5VST6
FAM108C1 family with sequence similarity 108, member C1 Human DNA Binding 58489 Q6PCB6
FAM110B Protein FAM110B Human DNA Binding 90362 Q8TC76
FAM116A DENN/MADD domain containing 6A Human DNA Binding 201627 Q8IWF6
FAM117B family with sequence similarity 117, member B Human DNA Binding 150864 Q6P1L5
FAM120A family with sequence similarity 120A Human DNA Binding 23196 Q9NZB2
FAM120AOS family with sequence similarity 120A opposite strand Human DNA Binding 158293 Q5T036
FAM122B family with sequence similarity 122B Human DNA Binding 159090 Q7Z309
FAM125A multivesicular body subunit 12A Human DNA Binding 93343 Q96EY5
FAM133B Protein FAM133B Human DNA Binding 728640 Q5BKY9
FAM133DP family with sequence similarity 133, member D, pseudogene Human DNA Binding 728066 NA
FAM134A Protein FAM134A Human DNA Binding 79137 Q8NC44
FAM136A family with sequence similarity 136, member A Human DNA Binding 84908 Q96C01
FAM13A family with sequence similarity 13, member A Human DNA Binding 10144 O94988
FAM13B family with sequence similarity 13, member B Human DNA Binding 51306 Q9NYF5
FAM155A Transmembrane protein FAM155A Human DNA Binding 728215 B1AL88
FAM160B1 family with sequence similarity 160, member B1 Human DNA Binding 57700 Q5W0V3
FAM160B2 family with sequence similarity 160, member B2 Human DNA Binding 64760 Q86V87
FAM164C zinc finger, C2HC-type containing 1C Human DNA Binding NM_001042430 A0A024R6E6
FAM171A1 family with sequence similarity 171, member A1 Human DNA Binding 221061 B3KMX9
FAM172A family with sequence similarity 172, member A Human DNA Binding 83989 Q8WUF8
FAM173A Protein FAM173A Human DNA Binding 65990 Q9BQD7
FAM178A family with sequence similarity 178, member A Human DNA Binding 55719 Q6GMU6
FAM179B family with sequence similarity 179, member B Human DNA Binding 23116 Q9Y4F4
FAM185A family with sequence similarity 185, member A Human DNA Binding 222234 Q8N0U4
FAM189A1 family with sequence similarity 189, member A1 Human DNA Binding 23359 O60320
FAM204A family with sequence similarity 204, member A Human DNA Binding 63877 Q9H8W3
FAM208A Protein FAM208A Human DNA Binding 23272 Q9UK61
FAM20B SLC38A10 Human DNA Binding 9917 O75063
FAM211B Leucine-rich repeat-containing protein 75B Human DNA Binding 388886 Q2VPJ9
FAM219B Protein FAM219B Human DNA Binding 57184 Q5XKK7
FAM36A COX20 cytochrome C oxidase assembly factor Human DNA Binding NM_198076 B3KM21
FAM40A striatin interacting protein 1 Human DNA Binding 85369 Q5VSL9
FAM43A family with sequence similarity 43, member A Human DNA Binding NM_153690 Q8N2R8
FAM47E family with sequence similarity 47, member E Human DNA Binding 100129583 Q6ZV65
FAM55C neurexophilin and PC-esterase domain family, member 3 Human DNA Binding 91775 Q969Y0
FAM57A family with sequence similarity 57, member A Human DNA Binding 79850 Q8TBR7
FAM63A family with sequence similarity 63, member A Human DNA Binding 55793 D3DV11
FAM65A SNTG2 Human DNA Binding 79567 Q6ZS17
FAM69A family with sequence similarity 69, member A Human DNA Binding 388650 Q5T7M9
FAM72A family with sequence similarity 72, member A Human DNA Binding NM_001123168 Q5TYM5
FAM72B family with sequence similarity 72, member B Human DNA Binding NM_001100910 Q86X60
FAM72D family with sequence similarity 72, member D Human DNA Binding NM_207418 Q6L9T8
FAM73A family with sequence similarity 73, member A Human DNA Binding 374986 B4DK63
FAM83B family with sequence similarity 83, member B Human DNA Binding 222584 Q5T0W9
FAM89B family with sequence similarity 89, member B Human DNA Binding 23625 Q8N5H3
FAM92A1 family with sequence similarity 92, member A1 Human DNA Binding 137392 A1XBS5
FANCC Fanconi anemia, complementation group C Human DNA Binding 2176 Q00597
FANCM Fanconi anemia, complementation group M Human DNA Binding 57697 Q8IYD8
FAR1 fatty acyl CoA reductase 1 Human DNA Binding 84188 Q8WVX9
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial Human DNA Binding 10667 O95363
FASN fatty acid synthase Human DNA Binding 2194 P49327
FASTKD2 FAST kinase domains 2 Human DNA Binding 22868 Q9NYY8
FASTKD3 FAST kinase domains 3 Human DNA Binding 79072 Q14CZ7
FASTKD5 FAST kinase domain-containing protein 5 Human DNA Binding 60493 Q7L8L6
FAT1 FAT tumor suppressor homolog 1 (Drosophila) Human DNA Binding 2195 Q14517
FAT4 FAT atypical cadherin 4 Human DNA Binding NM_024582 B3KU84
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed Human DNA Binding 2197 P35544
FAXC Failed axon connections homolog Human DNA Binding 84553 Q5TGI0
FBLN1 fibulin 1 Human DNA Binding 2192 P23142
FBXL14 F-box and leucine-rich repeat protein 14 Human DNA Binding 144699 Q8N1E6
FBXL15 F-box and leucine-rich repeat protein 15 Human DNA Binding NM_024326 Q9H469
FBXL17 F-box and leucine-rich repeat protein 17 Human DNA Binding 64839 Q9UF56
FBXL19 F-box and leucine-rich repeat protein 19 Human DNA Binding 54620 Q6PCT2
FBXL19-AS1 FBXL19 antisense RNA 1 (head to head) Human DNA Binding 283932 Q494R0
FBXL2 F-box and leucine-rich repeat protein 2 Human DNA Binding NM_012157 Q9UKC9
FBXL4 F-box and leucine-rich repeat protein 4 Human DNA Binding 26235 Q9UKA2
FBXL5 F-box and leucine-rich repeat protein 5 Human DNA Binding 26234 Q9UKA1
FBXO11 F-box protein 11 Human DNA Binding 80204 Q86XK2
FBXO16 F-box protein 16 Human DNA Binding NM_172366 Q8IX29
FBXO17 F-box protein 17 Human DNA Binding 115290 Q96EF6
FBXO18 F-box protein, helicase, 18 Human DNA Binding 84893 B3KV95
FBXO21 F-box protein 21 Human DNA Binding 23014 O94952
FBXO24 F-box only protein 24 Human DNA Binding 26261 O75426
FBXO28 F-box protein 28 Human DNA Binding 23219 E9PEM8
FBXO33 F-box protein 33 Human DNA Binding 254170 Q7Z6M2
FBXO36 F-box protein 36 Human DNA Binding NM_174899 Q8NEA4
FBXO42 F-box protein 42 Human DNA Binding 54455 Q6P3S6
FBXO43 F-box protein 43 Human DNA Binding NM_001077528 Q4G163
FBXO5 F-box protein 5 Human DNA Binding 26271 Q9UKT4
FBXO7 F-box protein 7 Human DNA Binding 25793 Q9Y3I1
FBXO8 F-box protein 8 Human DNA Binding NM_012180 Q8IXA8
FBXO9 F-box protein 9 Human DNA Binding 26268 Q9UK97
FBXW5 F-box and WD repeat domain containing 5 Human DNA Binding 54661 Q969U6
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) Human DNA Binding NM_001017986 Q92637
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) Human DNA Binding NM_001136219 P12318
FCHSD2 FCH and double SH3 domains 2 Human DNA Binding 9873 O94868
FDFT1 farnesyl-diphosphate farnesyltransferase 1 Human DNA Binding 2222 P37268
FDPS farnesyl diphosphate synthase Human DNA Binding 2224 P14324
FDX1L ferredoxin 1-like Human DNA Binding NM_001031734 Q6P4F2
FEM1B fem-1 homolog b (C. elegans) Human DNA Binding 10116 Q9UK73
FER fer (fps/fes related) tyrosine kinase Human DNA Binding 2241 P16591
FGD5-AS1 FGD5 antisense RNA 1 Human DNA Binding 100505641 NA
FGD6 FYVE, RhoGEF and PH domain containing 6 Human DNA Binding 55785 Q6ZV73
FGF9 fibroblast growth factor 9 (glia-activating factor) Human DNA Binding 2254 P31371
FHOD3 formin homology 2 domain containing 3 Human DNA Binding 80206 Q2V2M9
FIP1L1 FIP1 like 1 (S. cerevisiae) Human DNA Binding 81608 B4DIR3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) Human DNA Binding 51024 Q9Y3D6
FITM2 fat storage-inducing transmembrane protein 2 Human DNA Binding 128486 Q8N6M3
FIZ1 FLT3-interacting zinc finger 1 Human DNA Binding 84922 Q96SL8
FKBP14 FK506 binding protein 14, 22 kDa Human DNA Binding 55033 Q9NWM8
FKBP1B FK506 binding protein 1B, 12.6 kDa Human DNA Binding NM_054033 P68106
FKBP4 FK506 binding protein 4, 59kDa Human DNA Binding 2288 Q02790
FKBP7 Peptidyl-prolyl cis-trans isomerase FKBP7 Human DNA Binding 51661 Q9Y680
FKRP fukutin related protein Human DNA Binding 79147 Q9H9S5
FLAD1 FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) Human DNA Binding 80308 Q8NFF5
FLJ10038 Human DNA Binding 55056 NA
FLJ22536 cancer susceptibility candidate 15 (non-protein coding) Human DNA Binding NR_015410
FLJ31306 PSMA3 antisense RNA 1 Human DNA Binding 379025 NA
FLJ33630 long intergenic non-protein coding RNA 1184 Human DNA Binding NR_015360
FLJ37453 cDNA FLJ37453 fis, clone BRAWH2010754 Human DNA Binding 729614 Q8N9F6
FLJ39739 long intergenic non-protein coding RNA 1138 Human DNA Binding NR_027468
FLJ42709 NR2F1 antisense RNA 1 Human DNA Binding 441094 NA
FLOT1 flotillin 1 Human DNA Binding 10211 O75955
FLRT2 Leucine-rich repeat transmembrane protein FLRT2 Human DNA Binding 23768 O43155
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 Human DNA Binding 28982 B2RB38
FLVCR1-AS1 FLVCR1 antisense RNA 1 (head to head) Human DNA Binding 642946 Q8TAF5
FMNL3 formin-like 3 Human DNA Binding 91010 Q8IVF7
FNBP4 formin binding protein 4 Human DNA Binding 23360 B3KNP0
FNDC3A fibronectin type III domain containing 3A Human DNA Binding 22862 Q9Y2H6
FOSL2 FOS-like antigen 2 Human DNA Binding 2355 P15408
FOXJ2 TNIP2 Human DNA Binding 55810 Q9P0K8
FOXJ3 forkhead box J3 Human DNA Binding 22887 Q9UPW0
FOXN2 forkhead box N2 Human DNA Binding 3344 P32314
FOXO1 forkhead box O1 Human DNA Binding 2308 Q12778
FOXO3 forkhead box O3 Human DNA Binding 2309 O43524
FRA10AC1 Protein FRA10AC1 Human DNA Binding 118924 Q70Z53
FRAS1 Fraser syndrome 1 Human DNA Binding 80144 A2RRR8
FRG1 FSHD region gene 1 Human DNA Binding 2483 Q14331
FRS2 fibroblast growth factor receptor substrate 2 Human DNA Binding 10818 Q8WU20
FSD1L fibronectin type III and SPRY domain containing 1-like Human DNA Binding NM_031919 Q8N450
FSIP1 fibrous sheath interacting protein 1 Human DNA Binding NM_152597 A0A024R9J2
FTSJD2 FtsJ methyltransferase domain containing 2 Human DNA Binding 23070 Q8N1G2
FUBP3 far upstream element (FUSE) binding protein 3 Human DNA Binding 8939 Q96I24
FUK TSC1 Human DNA Binding 197258 Q8N0W3
FUNDC2 FUN14 domain containing 2 Human DNA Binding 65991 Q9BWH2
FUS fused in sarcoma Human DNA Binding 2521 P35637
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) Human DNA Binding 84750 Q6P4F1
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) Human DNA Binding 170384 Q495W5
FUZ fuzzy planar cell polarity protein Human DNA Binding 80199 Q9BT04
FXN frataxin Human DNA Binding 2395 Q16595
FXR1 Fragile X retardation 1 Human DNA Binding 8087 P51114
FYN FYN oncogene related to SRC, FGR, YES Human DNA Binding 2534 P06241
FZD2 frizzled family receptor 2 Human DNA Binding 2535 Q14332
FZD8 frizzled family receptor 8 Human DNA Binding 8325 Q9H461
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 Human DNA Binding 9908 Q9UN86
GABBR1 Human DNA Binding
GABPA GA binding protein transcription factor, alpha subunit 60kDa Human DNA Binding 2551 A8IE48
GABPB1 GA binding protein transcription factor, beta subunit 1 Human DNA Binding 2553 Q06547
GABPB1-AS1 GABPB1 antisense RNA 1 Human DNA Binding 100129387 NA
GAD1 glutamate decarboxylase 1 (brain, 67kDa) Human DNA Binding 2571 Q8IVA8
GADD45A growth arrest and DNA-damage-inducible, alpha Human DNA Binding NM_001924 P24522
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 Human DNA Binding 90480 Q8TAE8
GALE UDP-glucose 4-epimerase Human DNA Binding 2582 Q14376
GALK2 galactokinase 2 Human DNA Binding 2585 Q01415
GALNT7 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) Human DNA Binding 51809 Q86SF2
GALR1 galanin receptor 1 Human DNA Binding NM_001480 P47211
GANC glucosidase, alpha; neutral C Human DNA Binding 2595 Q8TET4
GAPVD1 GTPase activating protein and VPS9 domains 1 Human DNA Binding 26130 B3KN67
GAR1 GAR1 ribonucleoprotein homolog (yeast) Human DNA Binding 54433 Q9NY12
GARS glycyl-tRNA synthetase Human DNA Binding 2617 P41250
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Human DNA Binding 2618 P22102
GAS1 growth arrest-specific 1 Human DNA Binding 2619 P54826
GAS5 growth arrest-specific 5 (non-protein coding) Human DNA Binding NR_002578
GATAD2B GATA zinc finger domain containing 2B Human DNA Binding 57459 Q8WXI9
GBA WNT2 Human DNA Binding 2629 P04062
GBA2 glucosidase, beta (bile acid) 2 Human DNA Binding 57704 Q9HCG7
GBE1 glucan (1,4-alpha-), branching enzyme 1 Human DNA Binding NM_000158 Q04446
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 Human DNA Binding 8729 Q92538
GCC1 GRIP and coiled-coil domain containing 1 Human DNA Binding 79571 Q96CN9
GCLM glutamate-cysteine ligase, modifier subunit Human DNA Binding 2730 P48507
GCSH glycine cleavage system protein H (aminomethyl carrier) Human DNA Binding NM_004483 P23434
GDI2 GDP dissociation inhibitor 2 Human DNA Binding 2665 P50395
GEMIN4 gem (nuclear organelle) associated protein 4 Human DNA Binding 50628 P57678
GEMIN5 gem (nuclear organelle) associated protein 5 Human DNA Binding 25929 B7ZLC9
GEMIN7 gem (nuclear organelle) associated protein 7 Human DNA Binding 79760 Q9H840
GEMIN8 gem (nuclear organelle) associated protein 8 Human DNA Binding 54960 Q9NWZ8
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) Human DNA Binding 51608 Q7L5D6
GFM2 G elongation factor, mitochondrial 2 Human DNA Binding 84340 Q969S9
GFOD2 glucose-fructose oxidoreductase domain containing 2 Human DNA Binding 81577 Q3B7J2
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 Human DNA Binding 26088 Q9UJY5
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 Human DNA Binding 23163 Q9NZ52
GGNBP2 gametogenetin binding protein 2 Human DNA Binding 79893 Q9H3C7
GGPS1 geranylgeranyl diphosphate synthase 1 Human DNA Binding 9453 O95749
GHITM growth hormone inducible transmembrane protein Human DNA Binding 27069 Q9H3K2
GID8 Glucose-induced degradation protein 8 homolog Human DNA Binding 54994 Q9NWU2
GIN1 gypsy retrotransposon integrase 1 Human DNA Binding NM_017676 Q9NXP7
GINS1 GINS complex subunit 1 (Psf1 homolog) Human DNA Binding 9837 Q14691
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 Human DNA Binding 28964 Q59FC3
GJA3 gap junction protein, alpha 3, 46kDa Human DNA Binding 2700 Q9Y6H8
GJA9 gap junction protein, alpha 9, 59kDa Human DNA Binding NM_030772 P57773
GLG1 golgi glycoprotein 1 Human DNA Binding 2734 Q92896
GLOD4 glyoxalase domain containing 4 Human DNA Binding 51031 Q9HC38
GLTSCR1 glioma tumor suppressor candidate region gene 1 Human DNA Binding 29998 Q9NZM4
GLUD1 glutamate dehydrogenase 1 Human DNA Binding 2746 E9KL48
GMFB glia maturation factor, beta Human DNA Binding 2764 P60983
GMNN geminin, DNA replication inhibitor Human DNA Binding 51053 O75496
GMPR2 guanosine monophosphate reductase 2 Human DNA Binding NM_016576 Q9P2T1
GMPS guanine monphosphate synthetase Human DNA Binding 8833 A8K639
GNA13 guanine nucleotide binding protein (G protein), alpha 13 Human DNA Binding 10672 Q14344
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type Human DNA Binding NM_002071 A8K1Y9
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like Human DNA Binding 54584 Q9BYB4
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) Human DNA Binding 26354 Q9BVP2
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like Human DNA Binding 54552 Q05DU1
GNPAT glyceronephosphate O-acyltransferase Human DNA Binding 8443 O15228
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 Human DNA Binding 64841 Q96EK6
GNS glucosamine (N-acetyl)-6-sulfatase Human DNA Binding 2799 P15586
GOLGA4 golgin A4 Human DNA Binding 2803 Q13439
GOLGA6L6 golgin A6 family-like 6 Human DNA Binding NM_001145004 A8MZA4
GOLGB1 golgin B1 Human DNA Binding 2804 F1T0J2
GON4L gon-4-like (C. elegans) Human DNA Binding 54856 Q3T8J9
GORAB golgin, RAB6-interacting Human DNA Binding NM_001146039 Q5T7V8
GORASP2 golgi reassembly stacking protein 2, 55kDa Human DNA Binding 26003 Q9H8Y8
GOSR1 golgi SNAP receptor complex member 1 Human DNA Binding 9527 O95249
GOSR2 golgi SNAP receptor complex member 2 Human DNA Binding 9570 O14653
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) Human DNA Binding 2806 P00505
GPATCH1 G patch domain containing 1 Human DNA Binding 55094 Q9BRR8
GPATCH8 G patch domain containing 8 Human DNA Binding 23131 Q9UKJ3
GPBP1 GC-rich promoter binding protein 1 Human DNA Binding 65056 Q86WP2
GPBP1L1 GC-rich promoter binding protein 1-like 1 Human DNA Binding 60313 Q9HC44
GPC1 glypican 1 Human DNA Binding 2817 P35052
GPR101 G protein-coupled receptor 101 Human DNA Binding 83550 Q96P66
GPR108 G protein-coupled receptor 108 Human DNA Binding 56927 Q9NPR9
GPR126 G protein-coupled receptor 126 Human DNA Binding 57211 Q86SQ4
GPR137 Integral membrane protein GPR137 Human DNA Binding 56834 Q96N19
GPR177 wntless Wnt ligand secretion mediator Human DNA Binding NM_024911 Q5T9L3
GPR63 G protein-coupled receptor 63 Human DNA Binding 81491 A8K1C4
GPR84 G protein-coupled receptor 84 Human DNA Binding NM_020370 Q9NQS5
GPSM3 G-protein signaling modulator 3 Human DNA Binding NM_022107 A0A024RCP6
GPX8 glutathione peroxidase 8 (putative) Human DNA Binding 493869 Q8TED1
GRAMD1A GRAM domain containing 1A Human DNA Binding 57655 Q96CP6
GRAP GRB2-related adaptor protein Human DNA Binding NM_006613 Q13588
GRID2 glutamate receptor, ionotropic, delta 2 Human DNA Binding 2895 O43424
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D Human DNA Binding 2906 O15399
GRIPAP1 GRIP1 associated protein 1 Human DNA Binding 56850 Q4V328
GRK4 G protein-coupled receptor kinase 4 Human DNA Binding 2868 P32298
GRPEL1 GrpE-like 1, mitochondrial (E. coli) Human DNA Binding 80273 Q9HAV7
GRPEL2 GrpE-like 2, mitochondrial (E. coli) Human DNA Binding 134266 Q8TAA5
GRSF1 G-rich RNA sequence binding factor 1 Human DNA Binding 2926 Q12849
GRWD1 glutamate-rich WD repeat containing 1 Human DNA Binding 83743 Q9BQ67
GSE1 Genetic suppressor element 1 Human DNA Binding 23199 Q14687
GSK3A glycogen synthase kinase 3 alpha Human DNA Binding 2931 P49840
GSPT1 G1 to S phase transition 1 Human DNA Binding 2935 P15170
GSR glutathione reductase Human DNA Binding 2936 P00390
GSTA4 glutathione S-transferase alpha 4 Human DNA Binding NM_001512 A0A024RD58
GSTCD glutathione S-transferase, C-terminal domain containing Human DNA Binding 79807 Q8NEC7
GSTO2 glutathione S-transferase omega 2 Human DNA Binding NM_183239 Q9H4Y5
GTF2A1 general transcription factor IIA, 1, 19/37kDa Human DNA Binding 2957 P52655
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa Human DNA Binding NM_001517 Q92759
GTF2IRD1 GTF2I repeat domain containing 1 Human DNA Binding 9569 Q9UHL9
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa Human DNA Binding 9329 B3KNH2
GTPBP1 GTP binding protein 1 Human DNA Binding 9567 O00178
GTPBP3 GTP binding protein 3 (mitochondrial) Human DNA Binding 84705 B7Z563
GTSF1 gametocyte specific factor 1 Human DNA Binding NM_144594 A0A024RB57
GUCD1 Protein GUCD1 Human DNA Binding 83606 Q96NT3
GULP1 GULP, engulfment adaptor PTB domain containing 1 Human DNA Binding 51454 Q9UBP9
H19 H19 fetal liver mRNA Human DNA Binding 14955 N/A
H1FX H1 histone family, member X Human DNA Binding 8971 Q92522
H1FX-AS1 H1FX antisense RNA 1 Human DNA Binding 339942 Q4G0G2
H2AFV H2A histone family, member V Human DNA Binding 94239 Q71UI9
H2AFY2 Core histone macro-H2A.2 Human DNA Binding 55506 Q9P0M6
H2AFZ H2A histone family, member Z Human DNA Binding 3015 P0C0S5
H3F3AP4 H3 histone, family 3A, pseudogene 4 Human DNA Binding 440926 NA
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Human DNA Binding 57531 Q8IYU2
HAND1 heart and neural crest derivatives expressed 1 Human Direct Regulation 15110 O96004
HAUS1 HAUS augmin-like complex, subunit 1 Human DNA Binding 115106 Q96CS2
HBS1L HBS1-like (S. cerevisiae) Human DNA Binding 10767 Q9Y450
HCFC1 host cell factor C1 (VP16-accessory protein) Human DNA Binding 3054 P51610
HCFC2 host cell factor C2 Human DNA Binding 29915 Q9Y5Z7
HDGF hepatoma-derived growth factor Human DNA Binding 3068 P51858
HEATR2 HEAT repeat containing 2 Human DNA Binding 54919 B3KPE2
HEATR6 HEAT repeat containing 6 Human DNA Binding 63897 Q6AI08
HEBP1 heme binding protein 1 Human DNA Binding NM_015987 A0A024RAS8
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 Human DNA Binding 25831 Q9ULT8
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 Human DNA Binding 143279 B3KV18
HELLS helicase, lymphoid-specific Human DNA Binding 3070 Q9NRZ9
HELZ helicase with zinc finger Human DNA Binding 9931 P42694
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 Human DNA Binding 8916 B4DK41
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 Human DNA Binding 26091 Q5GLZ8
HES7 hes family bHLH transcription factor 7 Human DNA Binding NM_001165967 Q9BYE0
HEXIM2 hexamethylene bis-acetamide inducible 2 Human DNA Binding 124790 Q96MH2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 Human DNA Binding NM_012258 Q9Y5J3
HFE hemochromatosis Human DNA Binding 3077 Q30201
HHLA3 HERV-H LTR-associating 3 Human DNA Binding NM_001036646 Q9XRX5
HIAT1 hippocampus abundant transcript 1 Human DNA Binding 64645 Q96MC6
HINT2 histidine triad nucleotide binding protein 2 Human DNA Binding NM_032593 Q9BX68
HIPK2 homeodomain interacting protein kinase 2 Human DNA Binding 28996 Q9H2X6
HIPK3 Human DNA Binding
HIRA HIR histone cell cycle regulation defective homolog A (S. cerevisiae) Human DNA Binding 7290 P54198
HIST1H1B histone cluster 1, H1b Human DNA Binding 3009 P16401
HIST1H1C histone cluster 1, H1c Human DNA Binding 3006 P16403
HIST1H2AB histone cluster 1, H2ab Human DNA Binding 8335 P04908
HIST1H2AC histone cluster 1, H2ac Human DNA Binding 8334 Q93077
HIST1H2AG histone cluster 1, H2ag Human DNA Binding 8969 A4FTV9
HIST1H2AI histone cluster 1, H2ai Human DNA Binding 8329 A4FTV9
HIST1H2BF histone cluster 1, H2bf Human DNA Binding 8343 B2R4S9
HIST1H2BH histone cluster 1, H2bh Human DNA Binding NM_003524 Q93079
HIST1H2BJ histone cluster 1, H2bj Human DNA Binding 8970 P06899
HIST1H2BL histone cluster 1, H2bl Human DNA Binding NM_003519 Q99880
HIST1H2BN histone cluster 1, H2bn Human DNA Binding 8341 Q99877
HIST1H2BO histone cluster 1, H2bo Human DNA Binding 8348 P23527
HIST1H3B histone cluster 1, H3b Human DNA Binding 8358 P68431
HIST1H3D histone cluster 1, H3d Human DNA Binding 8351 P68431
HIST1H3E histone cluster 1, H3e Human DNA Binding 8353 P68431
HIST1H3F histone cluster 1, H3f Human DNA Binding 8968 P68431
HIST1H3H histone cluster 1, H3h Human DNA Binding 8357 P68431
HIST1H4B histone cluster 1, H4b Human DNA Binding 8366 B2R4R0
HIST1H4C histone cluster 1, H4c Human DNA Binding 8364 B2R4R0
HIST1H4E histone cluster 1, H4e Human DNA Binding 8367 B2R4R0
HIST1H4J histone cluster 1, H4j Human DNA Binding 8363 B2R4R0
HIST1H4K histone cluster 1, H4k Human DNA Binding 8362 B2R4R0
HIST2H2AA3 histone cluster 2, H2aa3 Human DNA Binding 8337 Q6FI13
HIST2H2AB histone cluster 2, H2ab Human DNA Binding 317772 Q8IUE6
HIST2H2AC histone cluster 2, H2ac Human DNA Binding 8338 Q16777
HJURP Holliday junction recognition protein Human DNA Binding 55355 Q8NCD3
HMBOX1 homeobox containing 1 Human DNA Binding 79618 Q6NT76
HMBS hydroxymethylbilane synthase Human DNA Binding NM_000190 P08397
HMG20A high mobility group 20A Human DNA Binding 10363 Q9NP66
HMGB1 high-mobility group box 1 Human DNA Binding 3146 P09429
HMGB2 high mobility group box 2 Human DNA Binding 3148 P26583
HMGN1 high mobility group nucleosome binding domain 1 Human DNA Binding 3150 P05114
HMGN2 high mobility group nucleosomal binding domain 2 Human DNA Binding 3151 P05204
HMGN4 high mobility group nucleosomal binding domain 4 Human DNA Binding 10473 O00479
HMGXB4 HMG box domain containing 4 Human DNA Binding 10042 Q7Z641
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 Human DNA Binding 3178 P09651
HNRNPA1P10 heterogeneous nuclear ribonucleoprotein A1 pseudogene 10 Human DNA Binding 664709 NA
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 Human DNA Binding 220988 P51991
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) Human DNA Binding 3183 P07910
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) Human DNA Binding 3189 P31942
HNRNPR heterogeneous nuclear ribonucleoprotein R Human DNA Binding 10236 O43390
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 Human DNA Binding 11100 Q9BUJ2
HNRNPUL2-BSCL2 HNRNPUL2-BSCL2 readthrough (NMD candidate) Human DNA Binding 100534595 NA
HNRPA1L-2 heterogeneous nuclear ribonucleoprotein A1 pseudogene 10 Human DNA Binding NR_002944
HNRPDL heterogeneous nuclear ribonucleoprotein D-like Human DNA Binding 9987 O14979
HNRPLL heterogeneous nuclear ribonucleoprotein L-like Human DNA Binding 92906 A8K894
HOMER3 homer homolog 3 (Drosophila) Human DNA Binding 9454 Q9NSC5
HOMEZ homeobox and leucine zipper encoding Human DNA Binding NM_020834 Q8IX15
HOXA2 homeobox A2 Human DNA Binding 3199 O43364
HOXA3 homeobox A3 Human DNA Binding 3200 O43365
HOXB2 homeobox B2 Human DNA Binding 3212 P14652
HOXB3 homeobox B3 Human DNA Binding 3213 B3KNJ7
HOXB4 homeobox B4 Human DNA Binding NM_024015 P17483
HOXB7 homeobox B7 Human DNA Binding 3217 P09629
HOXB8 homeobox B8 Human DNA Binding NM_024016 P17481
HOXB9 homeobox B9 Human DNA Binding NM_024017 B3KPJ1
HOXC10 homeobox C10 Human DNA Binding NM_017409 Q53XI4
HOXC6 homeobox C6 Human DNA Binding 3223 P09630
HOXC9 homeobox C9 Human DNA Binding NM_006897 A0A024RAZ6
HP1BP3 heterochromatin protein 1, binding protein 3 Human DNA Binding 50809 Q5SSJ5
HPD 4-hydroxyphenylpyruvate dioxygenase Human DNA Binding 3242 P32754
HPS4 Hermansky-Pudlak syndrome 4 Human DNA Binding 89781 A8K2E6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 Human DNA Binding NM_016245 Q8NBQ5
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 Human DNA Binding NM_016246 Q9BPX1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 Human DNA Binding 3326 P08238
HSPA6 heat shock 70kDa protein 6 (HSP70B') Human DNA Binding 3310 P17066
HSPA8 heat shock 70kDa protein 8 Human DNA Binding 3312 P11142
HSPBAP1 HSPB1-associated protein 1 Human DNA Binding 79663 Q96EW2
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Human DNA Binding 23640 Q9NZL4
HSPE1 heat shock 10kDa protein 1 (chaperonin 10) Human DNA Binding 3336 P61604
HUNK hormonally up-regulated Neu-associated kinase Human DNA Binding 30811 P57058
HUS1 HUS1 checkpoint homolog (S. pombe) Human DNA Binding 3364 A4D2F2
IARS isoleucyl-tRNA synthetase Human DNA Binding 3376 P41252
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) Human DNA Binding 200205 Q5T440
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase Human DNA Binding 25998 Q9P2D0
ICA1L islet cell autoantigen 1,69kDa-like Human DNA Binding NM_178231 A0A024R3W3
ICK intestinal cell (MAK-like) kinase Human DNA Binding 22858 Q9UPZ9
ICT1 immature colon carcinoma transcript 1 Human DNA Binding 3396 Q14197
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Human DNA Binding 3397 P41134
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein Human DNA Binding 3399 Q02535
IER2 immediate early response 2 Human DNA Binding 9592 Q9BTL4
IER3IP1 immediate early response 3 interacting protein 1 Human DNA Binding 51124 Q9Y5U9
IER5 immediate early response 5 Human DNA Binding 51278 Q5VY09
IFFO2 intermediate filament family orphan 2 Human DNA Binding 126917 Q5TF58
IFRD1 interferon-related developmental regulator 1 Human DNA Binding 3475 A4D0U1
IFRD2 interferon-related developmental regulator 2 Human DNA Binding 7866 Q12894
IFT52 intraflagellar transport 52 homolog (Chlamydomonas) Human DNA Binding 51098 Q9Y366
IFT74 intraflagellar transport 74 Human DNA Binding NM_001099222 A0PJM7
IFT80 intraflagellar transport 80 homolog (Chlamydomonas) Human DNA Binding 57560 Q9P2H3
IGDCC3 Immunoglobulin superfamily DCC subclass member 3 Human DNA Binding 9543 Q8IVU1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 Human DNA Binding 10642 Q9NZI8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 Human DNA Binding 10643 O00425
IGFBP3 insulin-like growth factor binding protein 3 Human DNA Binding NM_000598 B3KPF0
IGFL4 IGF-like family member 4 Human DNA Binding NM_001002923 Q6B9Z1
IGHMBP2 immunoglobulin mu binding protein 2 Human DNA Binding 3508 P38935
IKBIP IKBKB interacting protein Human DNA Binding 121457 Q70UQ0
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein Human DNA Binding 8518 O95163
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Human DNA Binding 3551 O14920
IKZF5 IKAROS family zinc finger 5 (Pegasus) Human DNA Binding 64376 Q9H5V7
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) Human DNA Binding 3572 P40189
ILF2 interleukin enhancer binding factor 2 Human DNA Binding 3608 Q12905
ILF3 interleukin enhancer binding factor 3, 90kDa Human DNA Binding 3609 Q12906
IMAA solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 2 Human DNA Binding NR_002594 Q9GIP4
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) Human DNA Binding 196294 Q96LU5
IMP4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) Human DNA Binding 92856 Q3ZTT3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 Human DNA Binding NM_014214 O14732
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 Human DNA Binding 3614 A4D0Z6
INA internexin neuronal intermediate filament protein, alpha Human DNA Binding 9118 Q16352
ING1 inhibitor of growth family, member 1 Human DNA Binding 3621 Q9UK53
ING3 inhibitor of growth family, member 3 Human DNA Binding 54556 Q9NXR8
ING4 inhibitor of growth family, member 4 Human DNA Binding NM_001127583 Q9UNL4
INHBC inhibin, beta C Human DNA Binding NM_005538 P55103
INO80 INO80 homolog (S. cerevisiae) Human DNA Binding 54617 Q9NUK2
INO80C INO80 complex subunit C Human DNA Binding NM_194281 Q6PI98
INO80D INO80 complex subunit D Human DNA Binding 54891 Q53TQ3
INSIG2 insulin induced gene 2 Human DNA Binding NM_016133 A0A024RAI2
INSR insulin receptor Human DNA Binding 3643 P06213
INTS2 integrator complex subunit 2 Human DNA Binding 57508 Q9H0H0
INTS6 integrator complex subunit 6 Human DNA Binding 26512 Q9UL03
INTS8 integrator complex subunit 8 Human DNA Binding 55656 Q75QN2
INTS9 integrator complex subunit 9 Human DNA Binding 55756 Q9NV88
INVS inversin Human DNA Binding 27130 Q2M1I4
IP6K2 inositol hexakisphosphate kinase 2 Human DNA Binding 51447 B2RCP4
IPO11 importin 11 Human DNA Binding 51194 Q9UI26
IPO7 importin 7 Human DNA Binding 10527 B3KNG9
IQCG IQ motif containing G Human DNA Binding NM_032263 Q9H095
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 Human DNA Binding NM_001010844 Q5VVH5
IRF2 interferon regulatory factor 2 Human DNA Binding 3660 P14316
IRF2BP1 interferon regulatory factor 2 binding protein 1 Human DNA Binding 26145 Q8IU81
IRF2BPL interferon regulatory factor 2 binding protein-like Human DNA Binding 64207 Q9H1B7
IRF8 interferon regulatory factor 8 Human Direct Regulation 3394 Q02556
IRGQ immunity-related GTPase family, Q Human DNA Binding 126298 Q8WZA9
IRS2 insulin receptor substrate 2 Human DNA Binding 8660 Q9P084
ISCU iron-sulfur cluster scaffold homolog (E. coli) Human DNA Binding 23479 Q9H1K1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 Human DNA Binding 81875 Q9H9L3
ISL2 ISL LIM homeobox 2 Human DNA Binding 64843 Q96A47
IST1 IST1 homolog Human DNA Binding 9798 P53990
ITFG1 integrin alpha FG-GAP repeat containing 1 Human DNA Binding 81533 Q8TB96
ITFG2 Integrin-alpha FG-GAP repeat-containing protein 2 Human DNA Binding 55846 Q969R8
ITFG3 integrin alpha FG-GAP repeat containing 3 Human DNA Binding 83986 Q9H0X4
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Human DNA Binding 3688 P05556
ITPK1 inositol-tetrakisphosphate 1-kinase Human DNA Binding 3705 Q13572
ITPKC inositol-trisphosphate 3-kinase C Human DNA Binding 80271 Q96DU7
ITSN1 intersectin 1 (SH3 domain protein) Human DNA Binding 6453 Q15811
JARID2 jumonji, AT rich interactive domain 2 Human DNA Binding 3720 Q92833
JMJD5 lysine (K)-specific demethylase 8 Human DNA Binding NM_001145348 Q8N371
JMY junction mediating and regulatory protein, p53 cofactor Human DNA Binding 133746 Q8N9B5
JRKL jerky homolog-like (mouse) Human DNA Binding 8690 Q9Y4A0
JTB jumping translocation breakpoint Human DNA Binding 10899 O76095
JUB ajuba LIM protein Human DNA Binding 84962 Q96IF1
JUND jun D proto-oncogene Human DNA Binding 3727 P17535
KAAG1 kidney associated antigen 1 Human DNA Binding NM_181337 Q9UBP8
KANSL1 KAT8 regulatory NSL complex subunit 1 Human DNA Binding 284058 Q7Z3B3
KANSL1-AS1 KANSL1 antisense RNA 1 Human DNA Binding 644246 NA
KAT6A K(lysine) acetyltransferase 6A Human DNA Binding 7994 A5PKX7
KAT6B K(lysine) acetyltransferase 6B Human DNA Binding 23522 B2RWN8
KATNA1 katanin p60 (ATPase containing) subunit A 1 Human DNA Binding 11104 O75449
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 Human DNA Binding 81621 Q96I82
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 Human DNA Binding 25948 Q8IY47
KBTBD3 Kelch repeat and BTB domain-containing protein 3 Human DNA Binding 143879 Q8NAB2
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 Human DNA Binding 55709 Q9NVX7
KCMF1 potassium channel modulatory factor 1 Human DNA Binding 56888 Q9P0J7
KCNG3 potassium voltage-gated channel, subfamily G, member 3 Human DNA Binding 170850 Q8TAE7
KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1 Human DNA Binding NM_002238 O95259
KCTD1 potassium channel tetramerisation domain containing 1 Human DNA Binding 284252 Q719H9
KCTD15 potassium channel tetramerisation domain containing 15 Human DNA Binding 79047 Q96SI1
KCTD20 potassium channel tetramerisation domain containing 20 Human DNA Binding 222658 Q7Z5Y7
KCTD3 potassium channel tetramerisation domain containing 3 Human DNA Binding 51133 Q9Y597
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1 Human DNA Binding 79070 Q6UW63
KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 Human DNA Binding 143888 Q7Z4H8
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 Human DNA Binding 11014 P33947
KDM1A lysine (K)-specific demethylase 1A Human DNA Binding 23028 O60341
KDM2A lysine (K)-specific demethylase 2A Human DNA Binding 22992 D4QA03
KDM2B lysine (K)-specific demethylase 2B Human DNA Binding 84678 Q8NHM5
KDM3A lysine (K)-specific demethylase 3A Human DNA Binding 55818 Q9Y4C1
KDM3B lysine (K)-specific demethylase 3B Human DNA Binding 51780 Q7LBC6
KDM4A lysine (K)-specific demethylase 4A Human DNA Binding 9682 O75164
KDM4C lysine (K)-specific demethylase 4C Human DNA Binding 23081 Q9H3R0
KDM4D lysine (K)-specific demethylase 4D Human DNA Binding 55693 Q6B0I6
KDM5A lysine (K)-specific demethylase 5A Human DNA Binding 5927 P29375
KDM5B-AS1 prostate cancer associated transcript 6 (non-protein coding) Human DNA Binding 100506696 NA
KDM6A lysine (K)-specific demethylase 6A Human DNA Binding 7403 O15550
KDSR 3-ketodihydrosphingosine reductase Human DNA Binding 2531 Q06136
KIAA0101 KIAA0101 Human DNA Binding 9768 A6NNU5
KIAA0182 Gse1 coiled-coil protein Human DNA Binding 23199 Q14687
KIAA0195 KIAA0195 Human DNA Binding 9772 Q12767
KIAA0232 KIAA0232 Human DNA Binding 9778 Q92628
KIAA0317 apoptosis resistant E3 ubiquitin protein ligase 1 Human DNA Binding NM_001039479 O15033
KIAA0355 KIAA0355 Human DNA Binding 9710 O15063
KIAA0391 KIAA0391 Human DNA Binding 9692 O15091
KIAA0406 TELO2 interacting protein 1 Human DNA Binding NM_014657 O43156
KIAA0415 adaptor-related protein complex 5, zeta 1 subunit Human DNA Binding 9907 O43299
KIAA0495 TP73 antisense RNA 1 Human DNA Binding NM_207306 Q9UF72
KIAA0564 von Willebrand factor A domain containing 8 Human DNA Binding 23078 A3KMH1
KIAA0586 KIAA0586 Human DNA Binding 9786 Q6UV20
KIAA0753 KIAA0753 Human DNA Binding 9851 Q2KHM9
KIAA0907 KIAA0907 Human DNA Binding 22889 Q7Z7F0
KIAA0913 zinc finger, SWIM-type containing 8 Human DNA Binding NM_015037 A7E2V4
KIAA1267 KAT8 regulatory NSL complex subunit 1 Human DNA Binding 284058 Q7Z3B3
KIAA1310 KAT8 regulatory NSL complex subunit 3 Human DNA Binding 55683 Q9P2N6
KIAA1429 KIAA1429 Human DNA Binding 25962 Q69YN4
KIAA1430 cilia and flagella associated protein 97 Human DNA Binding NM_020827 Q9P2B7
KIAA1524 KIAA1524 Human DNA Binding 57650 Q8TCG1
KIAA1539 family with sequence similarity 214, member B Human DNA Binding NM_025182 Q7L5A3
KIAA1549 KIAA1549 Human DNA Binding 57670 Q9HCM3
KIAA1551 Uncharacterized protein KIAA1551 Human DNA Binding 55196 Q9HCM1
KIAA1586 KIAA1586 Human DNA Binding 57691 Q9HCI6
KIAA1737 KIAA1737 Human DNA Binding 85457 Q9C0C6
KIAA1958 KIAA1958 Human DNA Binding 158405 Q8N8K9
KIAA1984-AS1 CCDC183 antisense RNA 1 Human DNA Binding 100131193 NA
KIAA2026 KIAA2026 Human DNA Binding 158358 Q5HYC2
KIF11 kinesin family member 11 Human DNA Binding 3832 P52732
KIF13A kinesin family member 13A Human DNA Binding 63971 Q9H1H9
KIF18A kinesin family member 18A Human DNA Binding 81930 Q8NI77
KIF1B kinesin family member 1B Human DNA Binding 23095 O60333
KIF20B kinesin family member 20B Human DNA Binding 9585 Q96Q89
KIF27 kinesin family member 27 Human DNA Binding NM_017576 Q86VH2
KIF3C kinesin family member 3C Human DNA Binding 3797 O14782
KIF9-AS1 KIF9 antisense RNA 1 Human DNA Binding 285352 NA
KIFC1 kinesin family member C1 Human DNA Binding 3833 Q9BW19
KISS1R KISS1 receptor Human DNA Binding NM_032551 Q969F8
KLC1 kinesin light chain 1 Human DNA Binding 3831 Q07866
KLC2 kinesin light chain 2 Human DNA Binding 64837 Q9H0B6
KLF12 Kruppel-like factor 12 Human DNA Binding 11278 Q8WWI3
KLF7 Krueppel-like factor 7 Human DNA Binding 8609 O75840
KLHDC2 kelch domain containing 2 Human DNA Binding 23588 Q9Y2U9
KLHL18 kelch-like family member 18 Human DNA Binding 23276 O94889
KLHL21 kelch-like family member 21 Human DNA Binding 9903 Q9UJP4
KLHL24 kelch-like family member 24 Human DNA Binding 54800 Q6TFL4
KLHL28 kelch-like 28 (Drosophila) Human DNA Binding 54813 Q9NXS3
KLHL35 Kelch-like protein 35 Human DNA Binding 283212 Q6PF15
KLHL42 kelch-like family member 42 Human DNA Binding 57542 B2RNT7
KLHL8 kelch-like family member 8 Human DNA Binding 57563 Q49A95
KLLN Killin Human DNA Binding 100144748 B2CW77
KNTC1 kinetochore associated 1 Human DNA Binding 9735 P50748
KPNA1 karyopherin alpha 1 (importin alpha 5) Human DNA Binding 3836 P52294
KPNA4 karyopherin alpha 4 (importin alpha 3) Human DNA Binding 3840 O00629
KPNA5 karyopherin alpha 5 (importin alpha 6) Human DNA Binding 3841 O15131
KPNA6 karyopherin alpha 6 (importin alpha 7) Human DNA Binding 23633 O60684
KPTN kaptin (actin binding protein) Human DNA Binding 11133 Q9Y664
KRIT1 KRIT1, ankyrin repeat containing Human DNA Binding NM_004912 O00522
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) Human DNA Binding 11103 Q13601
LACE1 lactation elevated 1 Human DNA Binding 246269 Q8WV93
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) Human DNA Binding 10314 O43813
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) Human DNA Binding 55915 B3KTN5
LAPTM4B lysosomal protein transmembrane 4 beta Human DNA Binding 55353 Q86VI4
LARP7 La ribonucleoprotein domain family, member 7 Human DNA Binding NM_015454 Q4G0J3
LAS1L LAS1-like (S. cerevisiae) Human DNA Binding 81887 Q9Y4W2
LASP1 LIM and SH3 protein 1 Human DNA Binding NM_006148 B4DIC4
LASS5 ceramide synthase 5 Human DNA Binding NM_147190 Q8N5B7
LBR lamin B receptor Human DNA Binding 3930 Q14739
LCA5 Leber congenital amaurosis 5 Human DNA Binding 167691 Q86VQ0
LCMT1 leucine carboxyl methyltransferase 1 Human DNA Binding NM_016309 Q9UIC8
LCORL Ligand-dependent nuclear receptor corepressor-like protein Human DNA Binding 254251 Q8N3X6
LDB1 LIM domain binding 1 Human DNA Binding 8861 Q86U70
LDHA lactate dehydrogenase A Human DNA Binding 3939 P00338
LDLRAD4 Low-density lipoprotein receptor class A domain-containing protein 4 Human DNA Binding 753 O15165
LENG1 leukocyte receptor cluster (LRC) member 1 Human DNA Binding NM_024316 Q96BZ8
LENG9 leukocyte receptor cluster (LRC) member 9 Human DNA Binding NM_198988 Q96B70
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 Human DNA Binding 137994 Q2VYF4
LIAS lipoic acid synthetase Human DNA Binding NM_194451 O43766
LIG3 ligase III, DNA, ATP-dependent Human DNA Binding 3980 E5KLB6
LIG4 ligase IV, DNA, ATP-dependent Human DNA Binding 3981 P49917
LIMD1-AS1 LIMD1 antisense RNA 1 Human DNA Binding 644714 NA
LIMD2 LIM domain-containing protein 2 Human DNA Binding 80774 Q9BT23
LIMS1 LIM and senescent cell antigen-like domains 1 Human DNA Binding 3987 P48059
LIN28B lin-28 homolog B (C. elegans) Human DNA Binding 389421 Q6ZN17
LIN52 lin-52 DREAM MuvB core complex component Human DNA Binding NM_001024674 B3KN83
LIN7B lin-7 homolog B (C. elegans) Human DNA Binding NM_022165 Q9HAP6
LINC00167 long intergenic non-protein coding RNA 167 Human DNA Binding 440072 Q96N53
LINC00461 long intergenic non-protein coding RNA 461 Human DNA Binding 645323 NA
LINS lines homolog (Drosophila) Human DNA Binding 55180 Q8NG48
LIPT1 lipoyltransferase 1 Human DNA Binding NM_145198 Q9Y234
LMAN2 lectin, mannose-binding 2 Human DNA Binding 10960 Q12907
LMAN2L lectin, mannose-binding 2-like Human DNA Binding 81562 Q9H0V9
LMBR1 limb region 1 homolog (mouse) Human DNA Binding 64327 Q8WVP7
LMTK2 lemur tyrosine kinase 2 Human DNA Binding 22853 Q8IWU2
LNPEP leucyl/cystinyl aminopeptidase Human DNA Binding 4012 Q9UIQ6
LOC100009676 ZBTB11 antisense RNA 1 Human DNA Binding NR_024407
LOC100128164 Human DNA Binding 100128164 NA
LOC100128191 TMPO antisense RNA 1 Human DNA Binding NR_027157
LOC100128398 cDNA FLJ37429 fis, clone BRAWH2001666 Human DNA Binding 100128398 Q8N9G5
LOC100128788 SRRM2 antisense RNA 1 Human DNA Binding NR_027275
LOC100128822 long intergenic non-protein coding RNA 1003 Human DNA Binding 100128822 NA
LOC100129250 TOPORS antisense RNA 1 Human DNA Binding 100129250 NA
LOC100129361 small integral membrane protein 10 like 1 Human DNA Binding 100129361 NA
LOC100129387 GABPB1 antisense RNA 1 Human DNA Binding NR_024490
LOC100129716 ARRDC3 antisense RNA 1 Human DNA Binding NR_027435
LOC100129722 C9orf173 antisense RNA 1 Human DNA Binding 100129722 NA
LOC100129726 long intergenic non-protein coding RNA 1126 Human DNA Binding NR_027251
LOC100129961 CCNT2 antisense RNA 1 Human DNA Binding 100129961 NA
LOC100130155 MIR124-2 host gene Human DNA Binding 100130155 NA
LOC100130522 PARD6G antisense RNA 1 Human DNA Binding NR_028339
LOC100130581 long intergenic non-protein coding RNA 910 Human DNA Binding NR_027412
LOC100131691 MZF1 antisense RNA 1 Human DNA Binding NR_027334
LOC100133091 Human DNA Binding NR_029411
LOC100133315 Putative short transient receptor potential channel 2-like protein Human DNA Binding NR_029192 Q6ZNB5
LOC100133612 long intergenic non-protein coding RNA 1134 Human DNA Binding 100133612 NA
LOC100216545 KMT2E antisense RNA 1 (head to head) Human DNA Binding NR_024586
LOC100272217 Human DNA Binding 100272217 NA
LOC100289230 Human DNA Binding 100289230 NA
LOC100289361 Human DNA Binding 100289361 NA
LOC100289509 KCNIP2 antisense RNA 1 Human DNA Binding 100289509 NA
LOC100289511 Human DNA Binding NR_029378
LOC100302401 RASAL2 antisense RNA 1 Human DNA Binding NR_027982
LOC100306951 PITPNA antisense RNA 1 Human DNA Binding NR_028514
LOC100499489 Human DNA Binding 100499489 NA
LOC100506421 long intergenic non-protein coding RNA 1158 Human DNA Binding 100506421 NA
LOC100506714 NUP50 antisense RNA 1 (head to head) Human DNA Binding 100506714 NA
LOC100506834 Human DNA Binding 100506834 NA
LOC100507217 long intergenic non-protein coding RNA 1578 Human DNA Binding 100507217 NA
LOC100507266 STX18 antisense RNA 1 (head to head) Human DNA Binding 100507266 NA
LOC100507557 Human DNA Binding 100507557 NA
LOC100507634 Human DNA Binding 100507634 NA
LOC100630918 Human DNA Binding 100630918 NA
LOC145783 Human DNA Binding 145783 NA
LOC150381 PRR34 antisense RNA 1 Human DNA Binding NR_027034
LOC153684 Human DNA Binding NR_015447
LOC202781 PAXIP1 antisense RNA 1 (head to head) Human DNA Binding 202781 NA
LOC254100 SSSCA1 antisense RNA 1 (head to head) Human DNA Binding 254100 NA
LOC254128 NIFK antisense RNA 1 Human DNA Binding 254128 NA
LOC256880 Human DNA Binding 256880 NA
LOC282997 PDCD4 antisense RNA 1 Human DNA Binding 282997 NA
LOC285550 family with sequence similarity 200, member B Human DNA Binding NM_001145191 P0CF97
LOC285696 HCG1815023 Human DNA Binding 285696 Q8NB94
LOC286016 triosephosphate isomerase 1 pseudogene 2 Human DNA Binding NR_002187
LOC286190 LACTB2 antisense RNA 1 Human DNA Binding 286190 NA
LOC338799 long intergenic non-protein coding RNA 1089 Human DNA Binding NR_002809
LOC344967 Putative cytosolic acyl coenzyme A thioester hydrolase-like Human DNA Binding 344967 Q6ZUV0
LOC388692 Human DNA Binding NR_027002
LOC388789 long intergenic non-protein coding RNA 493 Human DNA Binding NR_015432
LOC389791 Putative uncharacterized protein FLJ37218 Human DNA Binding 389791 Q8N1Y9
LOC400027 long intergenic non-protein coding RNA 938 Human DNA Binding NR_028408
LOC400657 long intergenic non-protein coding RNA 909 Human DNA Binding 400657 NA
LOC400684 LOC400684 protein Human DNA Binding 400684 Q9BVU7
LOC400931 MIRLET7B host gene (non-protein coding) Human DNA Binding NR_027033
LOC440926 H3 histone, family 3A, pseudogene 4 Human DNA Binding NR_002315
LOC492303 gem (nuclear organelle) associated protein 8 pseudogene 4 Human DNA Binding NR_002830
LOC550643 long intergenic non-protein coding RNA 1420 Human DNA Binding NR_015367
LOC554203 JPX transcript, XIST activator (non-protein coding) Human DNA Binding NR_024582
LOC642502 Human DNA Binding NM_001089593
LOC642826 BMS1 pseudogene 6 Human DNA Binding NR_024495
LOC644656 LOC644656 protein Human DNA Binding 644656 Q9BT31
LOC644961 actin gamma 1 pseudogene 20 Human DNA Binding 644961 NA
LOC646719 NIPBL antisense RNA 1 (head to head) Human DNA Binding 646719 NA
LOC646903 Human DNA Binding 646903 NA
LOC729013 ZBED5 antisense RNA 1 Human DNA Binding 729013 NA
LOC729683 Human DNA Binding 729683 NA
LOC729970 Human DNA Binding 729970 NA
LOC730183 Human DNA Binding 730183 NA
LOC84989 JMJD1C antisense RNA 1 Human DNA Binding NR_027182
LOC93622 Human DNA Binding NR_015433
LOX lysyl oxidase Human Direct Regulation 4015 B7ZAJ4
LPGAT1 lysophosphatidylglycerol acyltransferase 1 Human DNA Binding 9926 Q53YL2
LPIN1 lipin 1 Human DNA Binding 23175 B4DGS4
LPIN2 lipin 2 Human DNA Binding NM_014646 Q92539
LPXN leupaxin Human DNA Binding 9404 O60711
LRCH4 Leucine-rich repeat and calponin homology domain-containing protein 4 Human DNA Binding 4034 O75427
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 Human DNA Binding 57622 Q9P244
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 Human DNA Binding 79414 Q9BTN0
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 Human DNA Binding 78999 Q6PJG9
LRP12 low density lipoprotein receptor-related protein 12 Human DNA Binding 29967 Q59H02
LRP3 Human DNA Binding
LRP4-AS1 LRP4 antisense RNA 1 Human DNA Binding 100507401 NA
LRP6 low density lipoprotein receptor-related protein 6 Human DNA Binding 4040 O75581
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Human DNA Binding 7804 Q14114
LRRC14 leucine rich repeat containing 14 Human DNA Binding 9684 Q15048
LRRC16A leucine rich repeat containing 16A Human DNA Binding 55604 Q5VZK9
LRRC20 leucine rich repeat containing 20 Human DNA Binding 55222 Q8TCA0
LRRC27 leucine rich repeat containing 27 Human DNA Binding 80313 B3KUK5
LRRC37B2 leucine rich repeat containing 37B pseudogene 1 Human DNA Binding NR_015341
LRRC41 leucine rich repeat containing 41 Human DNA Binding NM_006369 Q15345
LRRC47 leucine rich repeat containing 47 Human DNA Binding 57470 Q8N1G4
LRRC48 leucine rich repeat containing 48 Human DNA Binding NM_001130092 B3KSC6
LRRC4B Human DNA Binding
LRRC8C leucine rich repeat containing 8 family, member C Human DNA Binding 84230 Q8TDW0
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 Human DNA Binding 9209 Q9Y608
LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) Human DNA Binding 27257 O15116
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) Human DNA Binding 26065 Q8ND56
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) Human DNA Binding 149986 Q9BX40
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) Human DNA Binding 57819 Q9Y333
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) Human DNA Binding 25804 Q9Y4Z0
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) Human DNA Binding NM_016200 A4D0W0
LSMD1 LSM domain containing 1 Human DNA Binding 84316 Q9BRA0
LTA4H leukotriene A4 hydrolase Human DNA Binding 4048 P09960
LTV1 LTV1 homolog (S. cerevisiae) Human DNA Binding 84946 Q96GA3
LUC7L LUC7-like (S. cerevisiae) Human DNA Binding 55692 Q9NQ29
LUC7L2 LUC7-like 2 (S. cerevisiae) Human DNA Binding 51631 Q9Y383
LYPLA1 lysophospholipase I Human DNA Binding 10434 O75608
LYRM2 LYR motif containing 2 Human DNA Binding 57226 Q9NU23
LZIC leucine zipper and CTNNBIP1 domain containing Human DNA Binding 84328 Q8WZA0
LZTFL1 leucine zipper transcription factor-like 1 Human DNA Binding NM_020347 Q9NQ48
LZTR1 leucine-zipper-like transcription regulator 1 Human DNA Binding 8216 Q8N653
MAD2L1BP MAD2L1 binding protein Human DNA Binding 9587 E9PAT7
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) Human DNA Binding 10459 Q9UI95
MAEA macrophage erythroblast attacher Human DNA Binding 10296 Q7L5Y9
MAF1 MAF1 homolog (S. cerevisiae) Human DNA Binding 84232 Q9H063
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) Human Protein Binding 4097 O15525
MAGEF1 melanoma antigen family F, 1 Human DNA Binding 64110 Q9HAY2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 Human DNA Binding 9223 Q96QZ7
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) Human DNA Binding NR_002819
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Human DNA Binding 10892 Q9UDY8
MAML1 mastermind-like 1 (Drosophila) Human DNA Binding 9794 Q92585
MAML3 mastermind-like 3 (Drosophila) Human DNA Binding 55534 Q96JK9
MAN2C1 Alpha-mannosidase 2C1 Human DNA Binding 4123 Q9NTJ4
MANBA mannosidase, beta A, lysosomal Human DNA Binding 4126 O00462
MANEAL mannosidase, endo-alpha-like Human DNA Binding 149175 Q5VSG8
MANF mesencephalic astrocyte-derived neurotrophic factor Human DNA Binding NM_006010 A8K878
MAP2 Microtubule-associated protein 2 Human DNA Binding 4133 P11137
MAP2K4 mitogen-activated protein kinase kinase 4 Human DNA Binding 6416 P45985
MAP2K5 mitogen-activated protein kinase kinase 5 Human DNA Binding 5607 Q13163
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Human DNA Binding 4214 Q13233
MAP3K12 mitogen-activated protein kinase kinase kinase 12 Human DNA Binding 7786 Q12852
MAP3K4 mitogen-activated protein kinase kinase kinase 4 Human DNA Binding 4216 Q9P1M2
MAP3K7 mitogen-activated protein kinase kinase kinase 7 Human DNA Binding 6885 O43318
MAP3K7IP2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 Human DNA Binding NM_015093 Q9NYJ8
MAP3K8 mitogen-activated protein kinase kinase kinase 8 Human DNA Binding NM_005204 P41279
MAP4 microtubule-associated protein 4 Human DNA Binding 4134 P27816
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 Human DNA Binding 9448 O95819
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 Human DNA Binding 11183 B3KWC4
MAP6D1 MAP6 domain containing 1 Human DNA Binding NM_024871 Q9H9H5
MAPK1 mitogen-activated protein kinase 1 Human DNA Binding 5594 P28482
MAPK11 mitogen-activated protein kinase 11 Human DNA Binding 5600 Q15759
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like Human DNA Binding 93487 Q8NDC0
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 Human DNA Binding 23542 Q13387
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 Human DNA Binding 8550 Q8IW41
MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1 Human DNA Binding 51275 Q8N8E1
MAPKBP1 mitogen-activated protein kinase binding protein 1 Human DNA Binding NM_001128608 O60336
MARCH7 E3 ubiquitin-protein ligase MARCH7 Human DNA Binding 64844 Q9H992
MARK2 MAP/microtubule affinity-regulating kinase 2 Human DNA Binding 2011 Q7KZI7
MARS methionyl-tRNA synthetase Human DNA Binding 4141 P56192
MARS2 methionyl-tRNA synthetase 2, mitochondrial Human DNA Binding 92935 Q96GW9
MASTL microtubule associated serine/threonine kinase-like Human DNA Binding 84930 Q96GX5
MAT2A methionine adenosyltransferase II, alpha Human DNA Binding 4144 P31153
MAT2B methionine adenosyltransferase II, beta Human DNA Binding 27430 Q9NZL9
MATR3 matrin 3 Human DNA Binding 9782 P43243
MBL1P1 mannose-binding lectin (protein A) 1, pseudogene Human DNA Binding NR_002724
MBLAC2 Metallo-beta-lactamase domain-containing protein 2 Human DNA Binding 153364 Q68D91
MBNL1 muscleblind-like splicing regulator 1 Human DNA Binding 4154 Q9NR56
MBOAT2 membrane bound O-acyltransferase domain containing 2 Human DNA Binding 129642