DLGAP1 DLG associated protein 1
Model Species
Mus musculusGene Aliases
4933422O14Rik, 9630002F18, AI845682, AI848168, BB075781, D17Bwg0511e, GKAP/SAPAP, GKPA/SAPAP, Gkap, Sapap1, mKIAA4162Models / Rescue Models
-Rescue Model
-Model Summary
Dlgap1 KO mice showed disrupted protein interactions in the postsynaptic density, and deficits in sociability. Ambulation, rearing, anxiety, depression, locomotion, startle response and nest building were largely unaffected. Induced grooming and exploration activity were decreased (Coba MP, et al, Sci. Rep., 2018).
External Links
Reports related to DLGAP1 (2 Reports)
| # | Type | Title | Author, Year |
|---|---|---|---|
| 1 | Primary | Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. | Coba MP , et al. (2018) |
| 2 | additional | Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2 | Horner AE et al. (2021) |
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Show all Phenotypic Profiles
M_DLGAP1_1_KO_HM
Model Type: Genetic
Model Genotype: Homozygous
Mutation:
Mice harboring a homozygous null mutation of the DLGAP1 allele. (No other information reported). .
Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129*C57BL/6 J
Es cell line: Not reported
Model Source: Dr. Seth Grant at Edinburgh University.
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Motor phenotype | Self grooming: artificial stress evoked | Decreased | Splash test to evoke grooming behavior | 2-2.75 months | Coba MP , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Motor phenotype | General locomotor activity | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Sensory | Startle response | No change | Prepulse inhibition | 2-2.75 months | Coba MP , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-2.75 months | Coba MP , et al. (2018) |
| Social behavior | Rearing behavior | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Social behavior | Nest building behavior | No change | Nest building assay | 2-2.75 months | Coba MP , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Emotion | Exploratory activity | Decreased | Novel cage test | 2-2.75 months | Coba MP , et al. (2018) |
| Emotion | Depression | No change | Forced swim test | 2-2.75 months | Coba MP , et al. (2018) |
| Emotion | Depression | No change | Sucrose preference test | 2-2.75 months | Coba MP , et al. (2018) |
| Emotion | Anxiety | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Molecular profile | Targeted expression | Decreased | Co-immunoprecipitation | 2-2.75 months | Coba MP , et al. (2018) |
| Molecular profile | Protein expression level evidence | No change | Western blot | 2-2.75 months | Coba MP , et al. (2018) |
| Molecular profile | Protein binding | Decreased | Co-immunoprecipitation | 2-2.75 months | Coba MP , et al. (2018) |
| Molecular profile | Protein binding | No change | Co-immunoprecipitation | 2-2.75 months | Coba MP , et al. (2018) |
M_DLGAP1_2_KO_HT
Model Type: Genetic
Model Genotype: Heterozygous
Mutation:
Mice harboring a heterozygous null mutation of the DLGAP1 allele. (No other information reported). .
Allele Type: Knockout
Strain of Origin: Not reported
Genetic Background: 129*C57BL/6 J
Es cell line: Not reported
Model Source: Dr. Seth Grant at Edinburgh University.
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Circadian sleep/wake cycle | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Motor phenotype | Self grooming: artificial stress evoked | No change | Splash test to evoke grooming behavior | 2-2.75 months | Coba MP , et al. (2018) |
| Motor phenotype | General locomotor activity: ambulatory activity | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Motor phenotype | General locomotor activity | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Neuroanatomy / ultrastructure / cytoarchitecture | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Neurophysiology | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Repetitive behavior | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Seizure | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Sensory | Startle response | No change | Prepulse inhibition | 2-2.75 months | Coba MP , et al. (2018) |
| Sensory | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Social behavior | Social approach | Decreased | Three-chamber social approach test | 2-2.75 months | Coba MP , et al. (2018) |
| Social behavior | Rearing behavior | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Social behavior | Nest building behavior | No change | Nest building assay | 2-2.75 months | Coba MP , et al. (2018) |
| Physiological parameters | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Communications | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Developmental profile | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Emotion | Exploratory activity | No change | Novel cage test | 2-2.75 months | Coba MP , et al. (2018) |
| Emotion | Depression | No change | Forced swim test | 2-2.75 months | Coba MP , et al. (2018) |
| Emotion | Depression | No change | Sucrose preference test | 2-2.75 months | Coba MP , et al. (2018) |
| Emotion | Anxiety | No change | Open field test | 2-2.75 months | Coba MP , et al. (2018) |
| Immune response | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Learning & memory | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Maternal behavior | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
| Molecular profile | NA | Not reported | NA | NA | Coba MP , et al. (2018) |
M_DLGAP1_3_KO_HM
Model Type: Genetic LOF
Model Genotype: Homozygous
Mutation:
Mutant mice have dlgap1 exon 4 replaced with a selection cassette that creates a frameshift between exons 4 and 5. 795bp of dlgap1 genomic dna (x70662625 to x70663420; ensemble build 68) is replaced with ires-lacz-neo cassette.
Allele Type: Knockout
Strain of Origin: C57BL/6*129S5
Genetic Background: C57BL/6*129S5
Es cell line: E14TG2a
Model Source: University of Edinburgh
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Motor phenotype | Hyperactivity | No change | Home cage behavior | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Reaction time: cognitive flexibility | Decreased | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Visual discrimination learning | No change | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Reward reinforced choice behavior | No change | Operant conditioning paradigm | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Reaction time: visual discrimination | Decreased | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Cognitive flexibility | No change | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
M_DLGAP1_4_KO_HT
Model Type: Genetic LOF
Model Genotype: Heterozygous
Mutation:
Mutant mice have dlgap1 exon 4 replaced with a selection cassette that creates a frameshift between exons 4 and 5. 795bp of dlgap1 genomic dna (x70662625 to x70663420; ensemble build 68) is replaced with ires-lacz-neo cassette.
Allele Type: Knockout
Strain of Origin: C57BL/6*129S5
Genetic Background: C57BL/6*129S5
Es cell line: E14TG2a
Model Source: University of Edinburgh
Phenotypic Profile
| Category | Entity | Value Change | Experimental Paradigm | Age at Testing | Author, Year |
|---|---|---|---|---|---|
| Motor phenotype | Hyperactivity | No change | Home cage behavior | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Neuroanatomy / Ultrastructure / Cytoarchitecture | Reaction time: cognitive flexibility | No change | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Visual discrimination learning | No change | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Reward reinforced choice behavior | No change | Operant conditioning paradigm | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Reaction time: visual discrimination | No change | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
| Learning & memory | Cognitive flexibility | No change | Pairwise visual discrimination task | 10ââ¬â18weeks | Horner AE et al. (2021) |
CNVs associated with DLGAP1(1 Models)
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| 18p11.31 | 14 | Deletion-Duplication | 22 / 51 |