Genetic Mouse Models / FOXP1

FOXP1 Forkhead box P1

Model Species
Mus musculus
Gene Aliases
3110052D19Rik, 4932443N09Rik, AI461938, AW494214
Reports
6
Associated Human Genes
FOXP1
Models / Rescue Models
-
Rescue Model
-
Model Summary

Homozygous conditional brain-specific knockout mice display neuroanatomical anomalies in the striatum and hippocampus, as well as altered spontaneous synaptic transmission, and impaired cognitive function and social behavior.

External Links
Entrez GeneMouse Genome InformaticsAllen Brain Atlas
Reports related to FOXP1 (6 Reports)
# Type Title Author, Year
1 Additional Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Wang B , et al. (2004)
2 Primary Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour. Bacon C , et al. (2014)
3 Additional FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ , et al. (2015)
4 Additional Foxp1 in Forebrain Pyramidal Neurons Controls Gene Expression Required for Spatial Learning and Synaptic Plasticity. Araujo DJ , et al. (2017)
5 Additional Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1 +/- mice. Frhlich H , et al. (2019)
6 Additional Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism Xue Li et al. (2023)
Show all Construct Details Show all Phenotypic Profiles

M_FOXP1_1_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 11-12 of the Foxp1 gene using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6

Es cell line: SM1-129SVJ
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Frhlich H , et al. (2019)
Circadian sleep/wake cycle NA Not reported NA NA Bacon C , et al. (2014)
Motor phenotype NA Not reported NA NA Frhlich H , et al. (2019)
Motor phenotype Hyperactivity Increased Open field test Adult Bacon C , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Frhlich H , et al. (2019)
Neuroanatomy / Ultrastructure / Cytoarchitecture Size of cerebral ventricles: lateral ventricle Increased Immunohistochemistry Adult Bacon C , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: ventral striatum or nucleus accumbens Increased Histology Adult Bacon C , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen No change Immunohistochemistry E18 Bacon C , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Morphology of the basal ganglia: striatum: caudoputamen Decreased Histology P1, p21, adult Bacon C , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Hippocampal morphology Abnormal Histology Adult Bacon C , et al. (2014)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Abnormal Sholl analysis Unreported Bacon C , et al. (2014)
Neurophysiology NA Not reported NA NA Frhlich H , et al. (2019)
Neurophysiology Synaptic transmission: excitatory Decreased Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Neurophysiology Synaptic plasticity: hippocampal ltp No change Field potential recordings 3 weeks Bacon C , et al. (2014)
Neurophysiology Presynaptic function: paired-pulse facilitation No change Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Neurophysiology Miniature post synaptic current frequency: inhibitory No change Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Neurophysiology Miniature post synaptic current frequency: excitatory No change Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Neurophysiology Miniature post synaptic current amplitude: inhibitory No change Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Neurophysiology Miniature post synaptic current amplitude: excitatory Increased Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Neurophysiology Membrane potential No change Whole-cell patch clamp 3 weeks Bacon C , et al. (2014)
Repetitive behavior NA Not reported NA NA Frhlich H , et al. (2019)
Repetitive behavior Vertical jumping or back flipping Increased Open field test Adult Bacon C , et al. (2014)
Seizure NA Not reported NA NA Frhlich H , et al. (2019)
Seizure NA Not reported NA NA Bacon C , et al. (2014)
Sensory NA Not reported NA NA Frhlich H , et al. (2019)
Sensory Startle response: acoustic stimulus Decreased Acoustic startle reflex test Adult Bacon C , et al. (2014)
Sensory Sensorimotor gating Decreased Prepulse inhibition Adult Bacon C , et al. (2014)
Social behavior NA Not reported NA NA Frhlich H , et al. (2019)
Social behavior Social interaction Decreased Reciprocal social interaction test Adult Bacon C , et al. (2014)
Social behavior Nest building behavior Decreased Nest building assay Adult Bacon C , et al. (2014)
Physiological parameters NA Not reported NA NA Frhlich H , et al. (2019)
Physiological parameters NA Not reported NA NA Bacon C , et al. (2014)
Communications NA Not reported NA NA Frhlich H , et al. (2019)
Communications NA Not reported NA NA Bacon C , et al. (2014)
Developmental profile Size/growth Decreased Body weight measurement Adult Frhlich H , et al. (2019)
Developmental profile Digestive system morphology: gi tract wall Abnormal Histology P12.5 Frhlich H , et al. (2019)
Developmental profile Size/growth Decreased General observations Unreported Bacon C , et al. (2014)
Emotion NA Not reported NA NA Frhlich H , et al. (2019)
Emotion Anxiety Decreased Open field test Adult Bacon C , et al. (2014)
Emotion Anxiety Decreased Elevated plus maze test Adult Bacon C , et al. (2014)
Immune response NA Not reported NA NA Frhlich H , et al. (2019)
Immune response NA Not reported NA NA Bacon C , et al. (2014)
Learning & memory NA Not reported NA NA Frhlich H , et al. (2019)
Learning & memory Spatial reference memory Decreased Object-place recognition test Adult Bacon C , et al. (2014)
Learning & memory Object recognition memory Decreased Novel object recognition test Adult Bacon C , et al. (2014)
Maternal behavior NA Not reported NA NA Frhlich H , et al. (2019)
Maternal behavior NA Not reported NA NA Bacon C , et al. (2014)
Molecular profile Gene expression Abnormal Gene expression microarray E18.5, p1.5 Frhlich H , et al. (2019)
Molecular profile Gene expression Abnormal Gene expression microarray P1 Bacon C , et al. (2014)

M_FOXP1_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Gene targeting deletes the forkhead domain of Foxp1 and replaces it with the neomycin resistance gene using homologous recombination, hetereozygous mice were bred to obtain homozygous null embryos.

Allele Type: Targeted (knockout)
Strain of Origin: -
Genetic Background: 129Sv*C57BL/6

Es cell line: SM1-129SVJ
Model Source: PMID: 15342473
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Wang B , et al. (2004)
Motor phenotype NA Not reported NA NA Wang B , et al. (2004)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Wang B , et al. (2004)
Neurophysiology NA Not reported NA NA Wang B , et al. (2004)
Repetitive behavior NA Not reported NA NA Wang B , et al. (2004)
Seizure NA Not reported NA NA Wang B , et al. (2004)
Sensory NA Not reported NA NA Wang B , et al. (2004)
Social behavior NA Not reported NA NA Wang B , et al. (2004)
Physiological parameters NA Not reported NA NA Wang B , et al. (2004)
Communications NA Not reported NA NA Wang B , et al. (2004)
Developmental profile Mortality/lethality: embryonic Increased Survival analysis P0 Wang B , et al. (2004)
Developmental profile Cardiovascular development and function Decreased Histology E11.5, e14.5 Wang B , et al. (2004)
Emotion NA Not reported NA NA Wang B , et al. (2004)
Immune response NA Not reported NA NA Wang B , et al. (2004)
Learning & memory NA Not reported NA NA Wang B , et al. (2004)
Maternal behavior NA Not reported NA NA Wang B , et al. (2004)
Molecular profile Targeted expression Decreased Immunohistochemistry E13.5 Wang B , et al. (2004)
Molecular profile Gene expression Decreased In situ hybridization (ish) E11.5, e14.5 Wang B , et al. (2004)
Molecular profile Cell proliferation Increased Immunohistochemistry E13.5 Wang B , et al. (2004)

M_FOXP1_2_CKO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Conditional heterozygous deletion of exons 11-12 of the Foxp1 gene using Nestin-cre, in neuronal, glial and other cell types in the central and peripheral nervous system

Allele Type: Conditional loss-of-function
Strain of Origin: C57BL/6
Genetic Background: C57BL/6

Es cell line: SM1-129SVJ
Model Source: Not Specified
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Bacon C , et al. (2014)
Motor phenotype Hyperactivity No change Open field test Adult Bacon C , et al. (2014)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Bacon C , et al. (2014)
Neurophysiology NA Not reported NA NA Bacon C , et al. (2014)
Repetitive behavior NA Not reported NA NA Bacon C , et al. (2014)
Seizure NA Not reported NA NA Bacon C , et al. (2014)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test Adult Bacon C , et al. (2014)
Sensory Sensorimotor gating No change Prepulse inhibition Adult Bacon C , et al. (2014)
Social behavior Social interaction No change Reciprocal social interaction test Adult Bacon C , et al. (2014)
Social behavior Nest building behavior No change Nest building assay Adult Bacon C , et al. (2014)
Physiological parameters NA Not reported NA NA Bacon C , et al. (2014)
Communications NA Not reported NA NA Bacon C , et al. (2014)
Developmental profile NA Not reported NA NA Bacon C , et al. (2014)
Emotion NA Not reported NA NA Bacon C , et al. (2014)
Immune response NA Not reported NA NA Bacon C , et al. (2014)
Learning & memory Spatial reference memory No change Object-place recognition test Adult Bacon C , et al. (2014)
Learning & memory Object recognition memory No change Novel object recognition test Adult Bacon C , et al. (2014)
Maternal behavior NA Not reported NA NA Bacon C , et al. (2014)
Molecular profile NA Not reported NA NA Bacon C , et al. (2014)

M_FOXP1_3_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The N terminal two thirds of the protein was removed by targeted a lacZ_ neo cassette including the forkhead domain. The homozygous KO is embryonic lethal at E14.5.

Allele Type: Targeted (knockout)
Strain of Origin: -
Genetic Background: C57BL/6

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Araujo DJ , et al. (2015)
Motor phenotype Tremor No change General observations NA Araujo DJ , et al. (2015)
Motor phenotype Righting response No change Righting reflex test Adult Araujo DJ , et al. (2015)
Motor phenotype Motor coordination and balance No change Accelerating rotarod test Adult Araujo DJ , et al. (2015)
Motor phenotype Hyperactivity Increased Open field test Adult Araujo DJ , et al. (2015)
Motor phenotype Grip strength Decreased Grip strength test Adult Araujo DJ , et al. (2015)
Motor phenotype General locomotor activity No change Open field test Adult Araujo DJ , et al. (2015)
Motor phenotype Gait No change General observations Adult Araujo DJ , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Araujo DJ , et al. (2015)
Neurophysiology NA Not reported NA NA Araujo DJ , et al. (2015)
Repetitive behavior Self grooming: perseveration No change Grooming behavior assessments Adult Araujo DJ , et al. (2015)
Seizure NA Not reported NA NA Araujo DJ , et al. (2015)
Sensory Startle response: acoustic stimulus No change Acoustic startle reflex test Adult Araujo DJ , et al. (2015)
Social behavior Nest building behavior No change Nest building assay Adult Araujo DJ , et al. (2015)
Physiological parameters NA Not reported NA NA Araujo DJ , et al. (2015)
Communications Ultrasonic vocalization: isolation induced Decreased Monitoring ultrasonic vocalizations P4, p7 Araujo DJ , et al. (2015)
Communications Audible vocalization No change Monitoring vocalizations Adult Araujo DJ , et al. (2015)
Developmental profile Size/growth No change Body weight measurement Adult Araujo DJ , et al. (2015)
Emotion NA Not reported NA NA Araujo DJ , et al. (2015)
Immune response NA Not reported NA NA Araujo DJ , et al. (2015)
Learning & memory NA Not reported NA NA Araujo DJ , et al. (2015)
Maternal behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Molecular profile Targeted expression Decreased Western blot NA Araujo DJ , et al. (2015)
Molecular profile Gene expression Increased Quantitative pcr (qrt-pcr) 7 weeks Araujo DJ , et al. (2015)
Molecular profile Gene expression Decreased Quantitative pcr (qrt-pcr) 7 weeks Araujo DJ , et al. (2015)

M_FOXP1_4_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The Foxp1 het KO mice were crossed with Drd1a -td tomato reporter mice to identify Drd1a expressing neurons.

Allele Type: Targeted (knockout)
Strain of Origin: -
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Araujo DJ , et al. (2015)
Motor phenotype NA Not reported NA NA Araujo DJ , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Araujo DJ , et al. (2015)
Neurophysiology Spontaneous post synaptic events: excitatory currents No change Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents No change Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Neurophysiology Intrinsic membrane properties No change Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Neurophysiology Action potential property: firing rate No change Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Repetitive behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Seizure NA Not reported NA NA Araujo DJ , et al. (2015)
Sensory NA Not reported NA NA Araujo DJ , et al. (2015)
Social behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Physiological parameters NA Not reported NA NA Araujo DJ , et al. (2015)
Communications NA Not reported NA NA Araujo DJ , et al. (2015)
Developmental profile NA Not reported NA NA Araujo DJ , et al. (2015)
Emotion NA Not reported NA NA Araujo DJ , et al. (2015)
Immune response NA Not reported NA NA Araujo DJ , et al. (2015)
Learning & memory NA Not reported NA NA Araujo DJ , et al. (2015)
Maternal behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Molecular profile NA Not reported NA NA Araujo DJ , et al. (2015)

M_FOXP1_5_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

The Foxp1 het KO mice were crossed with Drd2-GFP reporter mice to identify Drd2 expressing neurons.

Allele Type: Targeted (knockout)
Strain of Origin: -
Genetic Background: -

Es cell line: -
Model Source: -
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Araujo DJ , et al. (2015)
Motor phenotype NA Not reported NA NA Araujo DJ , et al. (2015)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Araujo DJ , et al. (2015)
Neurophysiology Spontaneous post synaptic events: excitatory currents No change Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Neurophysiology Spontaneous post synaptic event amplitude: excitatory currents Decreased Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Neurophysiology Intrinsic membrane properties Increased Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Neurophysiology Action potential property: firing rate Increased Whole-cell patch clamp P18 Araujo DJ , et al. (2015)
Repetitive behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Seizure NA Not reported NA NA Araujo DJ , et al. (2015)
Sensory NA Not reported NA NA Araujo DJ , et al. (2015)
Social behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Physiological parameters NA Not reported NA NA Araujo DJ , et al. (2015)
Communications NA Not reported NA NA Araujo DJ , et al. (2015)
Developmental profile NA Not reported NA NA Araujo DJ , et al. (2015)
Emotion NA Not reported NA NA Araujo DJ , et al. (2015)
Immune response NA Not reported NA NA Araujo DJ , et al. (2015)
Learning & memory NA Not reported NA NA Araujo DJ , et al. (2015)
Maternal behavior NA Not reported NA NA Araujo DJ , et al. (2015)
Molecular profile NA Not reported NA NA Araujo DJ , et al. (2015)

M_FOXP1_6_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Conditional deletion of exons 11-12 of the Foxp1 gene using Emx1-cre, in neurons and glia of the neocortex, hippocampus and pallium, E10.5 onwards

Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background: C57BL/6J

Es cell line: Not Specified
Model Source: Jackson Laboratories (strain # 005628)
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Araujo DJ , et al. (2017)
Motor phenotype Swimming ability No change Morris water maze test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Motor phenotype General locomotor activity: ambulatory activity Increased Open field test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Motor phenotype General locomotor activity Increased Novel cage test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Increased Magnetic resonance imaging (mri) Adult (> 8 weeks) Araujo DJ , et al. (2017)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Magnetic resonance imaging (mri) Adult (> 8 weeks) Araujo DJ , et al. (2017)
Neurophysiology Synaptic plasticity: hippocampal ltp Decreased Whole-cell patch clamp 6-7 weeks Araujo DJ , et al. (2017)
Neurophysiology Epsp-spike relationship No change Whole-cell patch clamp 6-7 weeks Araujo DJ , et al. (2017)
Repetitive behavior NA Not reported NA NA Araujo DJ , et al. (2017)
Seizure NA Not reported NA NA Araujo DJ , et al. (2017)
Sensory Vision No change Morris water maze test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Sensory Pain or nociception No change Fear conditioning test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Sensory Hearing No change Fear conditioning test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Social behavior Social interaction Decreased Reciprocal social interaction test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Social behavior Nest building behavior Decreased Nest building assay Adult (> 8 weeks) Araujo DJ , et al. (2017)
Physiological parameters NA Not reported NA NA Araujo DJ , et al. (2017)
Communications Ultrasonic vocalization: interaction induced: opposite sex stimulus Decreased Monitoring ultrasonic vocalizations Adult (> 8 weeks) Araujo DJ , et al. (2017)
Developmental profile Size/growth No change Body weight measurement Adult (> 8 weeks) Araujo DJ , et al. (2017)
Developmental profile Mortality/lethality No change General observations Adult (> 8 weeks) Araujo DJ , et al. (2017)
Developmental profile General characteristics No change General observations Adult (> 8 weeks) Araujo DJ , et al. (2017)
Emotion Anxiety Increased Open field test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Immune response NA Not reported NA NA Araujo DJ , et al. (2017)
Learning & memory Spatial working memory Decreased Morris water maze test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Learning & memory Spatial reference memory Decreased Morris water maze test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Learning & memory Reward reinforced choice behavior: short-term memory Decreased T-maze test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Learning & memory Reward reinforced choice behavior No change Buried food test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of cue No change Fear conditioning test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Learning & memory Cued or contextual fear conditioning: memory of context No change Fear conditioning test Adult (> 8 weeks) Araujo DJ , et al. (2017)
Maternal behavior NA Not reported NA NA Araujo DJ , et al. (2017)
Molecular profile Targeted expression No change Western blot Adult (> 8 weeks) Araujo DJ , et al. (2017)
Molecular profile Targeted expression No change Immunohistochemistry Adult (> 8 weeks) Araujo DJ , et al. (2017)
Molecular profile Targeted expression Decreased Western blot Adult (> 8 weeks) Araujo DJ , et al. (2017)
Molecular profile Targeted expression Decreased Immunohistochemistry Adult (> 8 weeks) Araujo DJ , et al. (2017)
Molecular profile Gene expression Abnormal Quantitative pcr (qrt-pcr) 1.6 months Araujo DJ , et al. (2017)
Molecular profile Gene expression Abnormal Single-cell gene expression analysis Adult (> 8 weeks) Araujo DJ , et al. (2017)
Molecular profile Gene expression Abnormal Rna sequencing Adult (> 8 weeks) Araujo DJ , et al. (2017)

M_FOXP1_7_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous

Mutation:

Gene targeting deletes the forkhead domain of Foxp1 (exons 12, 13 and 14) and replaces it with the neomycin resistance gene using homologous recombination, hetereozygous mice were bred to obtain homozygous null embryos; 15342473; M_FOXP1_1_KO_HM

Allele Type: Targeted (knockout)
Strain of Origin: -
Genetic Background: 129Sv*C57BL/6

Es cell line: SM1-129SVJ
Model Source: PMID 15342473
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Circadian sleep/wake cycle NA Not reported NA NA Frhlich H , et al. (2019)
Motor phenotype General locomotor activity: ambulatory activity No change Novel cage test 8 weeks Frhlich H , et al. (2019)
Neuroanatomy / ultrastructure / cytoarchitecture NA Not reported NA NA Frhlich H , et al. (2019)
Neurophysiology NA Not reported NA NA Frhlich H , et al. (2019)
Repetitive behavior NA Not reported NA NA Frhlich H , et al. (2019)
Seizure NA Not reported NA NA Frhlich H , et al. (2019)
Sensory NA Not reported NA NA Frhlich H , et al. (2019)
Social behavior NA Not reported NA NA Frhlich H , et al. (2019)
Physiological parameters Satiety response Decreased Food intake measurements 8 weeks Frhlich H , et al. (2019)
Physiological parameters NA Not reported NA NA Frhlich H , et al. (2019)
Physiological parameters Digestive system function: sphincter function Increased In vitro carbachol-induced isometric smooth muscle contraction 8 weeks Frhlich H , et al. (2019)
Physiological parameters Digestive system function: gastrointestinal motility: peristaltic reflexes Increased Measurement of gi motility 8 weeks Frhlich H , et al. (2019)
Physiological parameters Digestive system function: gastrointestinal motility: gastric emptying No change Measurement of gi motility 8 weeks Frhlich H , et al. (2019)
Physiological parameters Digestive system function: gastrointestinal motility: colonic motility Abnormal Measurement of colonic motility 8 weeks Frhlich H , et al. (2019)
Physiological parameters Digestive system function: gastrointestinal motility: achalasia Increased Esophagealmanometry 8 weeks Frhlich H , et al. (2019)
Physiological parameters Digestive system function: dysphagia Decreased General observations 8 weeks Frhlich H , et al. (2019)
Physiological parameters Apoptosis No change Histology P12.5 Frhlich H , et al. (2019)
Communications NA Not reported NA NA Frhlich H , et al. (2019)
Developmental profile Size/growth No change Body weight measurement P12.5 Frhlich H , et al. (2019)
Developmental profile Size/growth Decreased Body weight measurement 8, 14, 24 weeks Frhlich H , et al. (2019)
Developmental profile Myogenesis Decreased Histology P12.5 Frhlich H , et al. (2019)
Developmental profile Digestive system morphology: intestine No change Gross necroscopy 8 weeks Frhlich H , et al. (2019)
Developmental profile Digestive system morphology: interstitial cells of cajal No change Histology P12.5, adult Frhlich H , et al. (2019)
Developmental profile Digestive system morphology: gi tract wall Abnormal Histology P12.5, adult Frhlich H , et al. (2019)
Developmental profile Digestive system morphology No change Histology P12.5, adult Frhlich H , et al. (2019)
Emotion Depression Increased Novel cage test 8 weeks Frhlich H , et al. (2019)
Immune response NA Not reported NA NA Frhlich H , et al. (2019)
Learning & memory NA Not reported NA NA Frhlich H , et al. (2019)
Maternal behavior NA Not reported NA NA Frhlich H , et al. (2019)
Molecular profile Targeted expression Decreased Quantitative pcr (qrt-pcr) P12.5, adult Frhlich H , et al. (2019)
Molecular profile Targeted expression Decreased Western blot P12.5, adult Frhlich H , et al. (2019)
Molecular profile Gene expression Decreased Quantitative pcr (qrt-pcr) Adult, p12.5 Frhlich H , et al. (2019)
Molecular profile Cytoskeletal organization No change Histology Adult Frhlich H , et al. (2019)
Molecular profile Cell proliferation Decreased Histology P12.5 Frhlich H , et al. (2019)

M_FOXP1_8_CKO_HM

Model Type: Genetic
Model Genotype: Homozygous

Mutation:

Foxp1flox/flox mice (MGI:4421653), with loxP sites on either side of exons 11 and 12 of the targeted Foxp1 gene, were crossed with the Emx1-Cre mice (MGI:2176219), where Cre recombinase is expressed specifically in the pyramidal neurons of the neocortex and hippocampus. Male Foxp1flox/flox; Emx1-Cre+ progenies were crossed with female Foxp1flox/flox mice to generate homozygous, forebrain-specific Foxp1 knockout mice.

Allele Type: Knockout
Strain of Origin: Not specified; 129S2/SvPas
Genetic Background: C57BL/6J

Es cell line: Not specified; D3
Model Source: Wenzhou Medical University
Phenotypic Profile
Category Entity Value Change Experimental Paradigm Age at Testing Author, Year
Motor phenotype Motor coordination and balance: fine motor skills No change Adhesive tape test 6-8 weeks Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Synapse density: excitatory Decreased Immunostaining 6 weeks Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Somatosensory cortical map architecture Abnormal Immunostaining P7, P35 Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density Decreased Golgi-Cox staining 6 weeks Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic tree complexity Decreased Sholl analysis 6 weeks Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic orientation Abnormal Golgi-Cox staining 6 weeks Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: dendritic length Decreased Sholl analysis 6 weeks Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Cortical thickness Decreased Histology P35 Xue Li et al. (2023)
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size Decreased Measurement of tissue weight P35 Xue Li et al. (2023)
Neurophysiology Neuronal activation following behavioral stimulation: c-fos levels Decreased Immunostaining 6-8 weeks Xue Li et al. (2023)
Neurophysiology Neuronal activation following behavioral stimulation: c-fos levels Increased Immunostaining 6-8 weeks Xue Li et al. (2023)
Repetitive behavior Repetitive digging Decreased Marble-burying test 6-8 weeks Xue Li et al. (2023)
Sensory Touch Decreased Adhesive tape test 6-8 weeks Xue Li et al. (2023)
Sensory Startle response: tactile stimulus Increased Whisker nuisance test 6-8 weeks Xue Li et al. (2023)
Sensory Hypersensitivity: tactile stimulus Increased Whisker nuisance test 6-8 weeks Xue Li et al. (2023)
Developmental profile Mortality/lethality No change General observations P0 Xue Li et al. (2023)
Emotion Fear response No change Whisker nuisance test 6-8 weeks Xue Li et al. (2023)
Emotion Exploratory activity Decreased Whisker nuisance test 6-8 weeks Xue Li et al. (2023)
Molecular profile Targeted expression Decreased Immunofluorescence staining P7 Xue Li et al. (2023)
CNVs associated with FOXP1(1 Models)
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