The data contained within the PIN module originate entirely from peer-reviewed publications. MindSpec researchers manually curate information on direct protein interactions of ASD risk genes based on a multi-level annotation model.

The steps involved in the curation of a PIN module entry are as follows:

  • 1.

    Consultation with publicly available molecular interaction databases (HPRD, BioGRID)

  • 2.

    Extraction from commercial molecular interaction software (Pathway Studio 7.1)

  • 3.

    Manual searches of PubMed using the following terms: (Gene Symbol OR Aliases) AND (interact* OR bind* OR regulat* OR function)

  • 4.

    Verification of every interaction by manually curating information directly from primary reference articles

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