Interactions
Interactomes for ASD candidate genes within the PIN module contain the following six types of direct protein interactions:
protein binding
Two proteins bind together; includes homodimerization
promoter binding
One protein binds to the promoter of another gene; can be either direction
RNA Binding
One protein binds to the mRNA encoded by another gene; can be either direction
Protein Modification
One protein promotes a post-translational modification of another protein (examples: phosphorylation, glycosylation, nitrosylation, oxidation, hydroxylation, ubiquitination, etc.); can be either direction
Direct Regulation
One protein directly affects the activity of another protein (examples: GTP hydrolysis, RNA splicing); can be either direction
Autoregulation
A protein regulates its own activity; typically by autophosphorylation